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https://www.readbyqxmd.com/read/28649763/transformations-of-some-sesquiterpene-lactones-by-filamentous-fungi-cytotoxic-evaluations
#1
Arturo Cano-Flores, Guillermo Delgado
Biotransformation is an economically and ecologically viable technology which has been used to modify the structures of many classes of biologically active products. Some fungi may be useful for the biotransformation of sesquiterpene lactones (SLs), leading to unusual structural changes that modify their biological activities, and other transformations mimic their biosynthetic pathways, generating evidences for the proposed biogenesis. Eight filamentous fungi were screened for their ability to transform different SLs (1-9), and microbial reactions yielded compounds 11 -- 18, which in turn have been isolated as natural products, thus mimicking their biosynthesis...
June 26, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28645906/an-umbilical-bleeding-nodule
#2
Hemal Shah, Salvador Diaz-Cano, Lucia Pozo-Garcia
No abstract text is available yet for this article.
June 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28643672/switch-from-agalsidase-beta-to-agalsidase-alfa-in-the-enzyme-replacement-therapy-of-patients-with-fabry-disease-in-latin-america
#3
Diego Ripeau, Hernán Amartino, Martín Cedrolla, Luis Urtiaga, Bella Urdaneta, Marilis Cano, Rita Valdez, Norberto Antongiovanni, Francisca Masllorens
There are currently two available enzyme replacement therapies for Fabry disease and little information regarding efficacy and safety of switching therapies. Between 2009 and 2012 there was a worldwide shortage of agalsidase beta and patients on that enzyme were switched to agalsidase alfa. This retrospective observational study assessed a 2-year period of efficacy and safety in a population of Fabry patients, in Argentina (30 patients) and Venezuela (3 patients), who switched therapies from algasidase beta to agalsidase alfa...
2017: Medicina
https://www.readbyqxmd.com/read/28639473/revision-and-new-species-of-vasotrema-stunkard-1926-digenea-schistosomatoidea-turtle-blood-flukes-of-north-american-softshell-turtles-testudines-trionychidae-apalone-spp
#4
Jackson Roberts, Stephen Ashton Bullard
Gulf Coast spiny softshell turtles, Apalone spinifera aspera (Agassiz, 1857), (Testudines: Trionychidae) from Canoe Lake (33°47'56.16"N, 86°29'25.02"W; Springville, Alabama, USA) and Round Lake (32°41'50.91"N, 87°14'30.39"W; Perry Lakes State Park, Marion, Alabama, USA) were infected by Vasotrema robustum Stunkard, 1928, Vasotrema longitestis Byrd, 1939, and Vasotrema rileyae n. sp. The new species differs from its congeners by having papillate suckers, a short testis, an ovary dextral to the oviduct, and a pre-ovarian genital pore that is lateral to the ventral sucker...
June 22, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28639397/ovarian-polarity-and-cell-shape-determination-by-btk29a-in-drosophila
#5
Noriko Hamada-Kawaguchi, Daisuke Yamamoto
Drosophila Btk29A is a Tec family nonreceptor tyrosine kinase, the ortholog of which causes X-linked agammagluburinemia in humans when mutant. In Btk29A(ficP) mutant ovaries, multiple defects are observed: extra polar cells form ectopically; osk mRNA fails to accumulate posteriorly in mature oocytes; the shape and alignment of follicle cells are grossly distorted. All these phenotypes are rescued by selectively overexpressing the type 2 isoform of wild-type Btk29A in follicle cells. Expression of certain proteins enriched in adherens junctions is markedly affected in Btk29A(ficP) mutants; the anterior-posterior gradient normally observed in the expression of DE-Cadherin and Armadillo are lost and Canoe is sequestered from adherens junctions...
June 22, 2017: Genesis: the Journal of Genetics and Development
https://www.readbyqxmd.com/read/28637559/complex-abdominal-wall-hernia-repair-in-contaminated-surgical-fields-factors-affecting-the-choice-of-prosthesis
#6
Manuel López-Cano, María Teresa Quiles, José Antonio Pereira, Manuel Armengol-Carrasco, María Antonia Arbós Vía
To compare patients with complex abdominal wall hernias undergoing surgical repair using synthetic nonabsorbable or biologic meshes in contaminated fields. Retrospective review of 62 patients with complex abdominal wall hernia with surgical repair in an elective setting and in the context of a clean-contaminated or contaminated fields (January 2009-April 2015). Two groups according to the prosthesis (synthetic nonabsorbable, n = 48 or biologic, n = 14). Mean follow-up was 24.6 (15.8) months. Clean-contaminated wounds were significantly more frequent in the synthetic group...
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28635651/effects-of-tetrodotoxin-in-mouse-models-of-visceral-pain
#7
Rafael González-Cano, Miguel Ángel Tejada, Antonia Artacho-Cordón, Francisco Rafael Nieto, José Manuel Entrena, John N Wood, Cruz Miguel Cendán
Visceral pain is very common and represents a major unmet clinical need for which current pharmacological treatments are often insufficient. Tetrodotoxin (TTX) is a potent neurotoxin that exerts analgesic actions in both humans and rodents under different somatic pain conditions, but its effect has been unexplored in visceral pain. Therefore, we tested the effects of systemic TTX in viscero-specific mouse models of chemical stimulation of the colon (intracolonic instillation of capsaicin and mustard oil) and intraperitoneal cyclophosphamide-induced cystitis...
June 21, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28634162/linking-the-content-to-demographic-reach-of-online-advertising-of-electronic-nicotine-delivery-systems
#8
David S Timberlake, Dmitriy Nikitin, Jennifer Garcia-Cano, Samantha Cino, Margarita Savkina, Cornelia Pechmann
INTRODUCTION: Recent studies have separately examined the content and demographic reach of the advertising of electronic nicotine delivery systems (ENDS). No study to our knowledge has linked the two in investigating whether racial/ethnic groups are differentially exposed to the comparative messages conveyed in online ENDS advertisements. METHODS: 932 unique ENDS advertisements (6311 total), which were posted on 3435 websites between December, 2009 and October, 2015, were categorized as either comparative or non-comparative with respect to the traditional cigarette...
June 20, 2017: Tobacco Control
https://www.readbyqxmd.com/read/28631823/a-comparative-study-between-labeling-and-reality-the-case-of-phytochemical-composition-of-commercial-pomegranate-based-products
#9
Marina Cano-Lamadrid, Leontina Lipan, Ángel Calín-Sánchez, Francisca Hernández, Ángel A Carbonell-Barrachina
Manufacturers are deeply involved in the development of new pomegranate-based products, which have acquired great prestige due to many studies proving their potential health benefits. Commercial pomegranate products including capsules and supplements and juices and nectars were assayed. The contents of the key phytochemical compounds (punicalagin, ellagic acid, and total polyphenolic content) and the associated antioxidant capacity (DPPH(•) , ABTS(•+) , and FRAP) were analyzed. The experimental ranges of punicalagin and ellagic acid contents were 0...
June 20, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28627212/efficacy-of-enteral-nutritional-support-after-hospital-discharge-in-major-gastrointestinal-surgery-patients-a-systematic-review
#10
Alfonso Vidal Casariego, Alicia Calleja Fernández, Rocío Villar Taibo, Ana Urioste Fondo, Begoña Pintor de la Maza, Ana Hernández Moreno, Isidoro Cano Rodríguez, María D Ballesteros Pomar
INTRODUCTION: Nutritional support for malnourished patients undergoing gastrointestinal surgery reduces the complication rate and shortens the length of stay. The efficacy of nutritional support after hospital discharge was analyzed in this systematic review. METHODS: The search strategy (nutrition OR "enteral nutrition" OR "nutritional supplements" OR "oral nutritional supplements" OR "sip feed" OR "sip feeding" OR "dietary counseling") AND ("patient discharge" OR discharge OR postdischarge) AND (surgery OR operation OR "surgical procedure") was followed in Medline, CENTRAL, and Trip databases...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28625840/survival-of-litopenaeus-vannemei-shrimp-fed-on-diets-supplemented-with-dunaliella-sp-is-improved-after-challenges-by-vibrio-parahaemolyticus
#11
Diana Medina Félix, José Antonio López Elías, Ángel Isidro Campa Córdova, Luis Rafael Martínez Córdova, Antonio Luna González, Edilmar Cortez Jacinto, Nolberta Huerta Aldaz, Fernando Cano Mendoza, María Guadalupe Burboa Zazueta
Survival of Litopenaeus vannamei was evaluated during a Vibrio parahaemolyticus infection. This bacteria has been causing significant economic losses in the shrimp industry due to the appearance of early mortality syndrome (EMS), also known as acute hepatopancreatic necrosis disease (AHPND). Control of bacteria in ponds is difficult to achieve with antibiotics due to environmental infections and antibiotic resistance. New methods have been proposed to control and prevent the impact of bacterial infections. The physiological response indicated by plasma biochemical parameters in shrimp can determine their health and stress status...
June 15, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28624262/dibenzazepine-loaded-nanoparticles-induce-local-browning-of-white-adipose-tissue-to-counteract-obesity
#12
Chunhui Jiang, Mario Alberto Cano-Vega, Feng Yue, Liangju Kuang, Naagarajan Narayanan, Gozde Uzunalli, Madeline P Merkel, Shihuan Kuang, Meng Deng
Inhibition of Notch signaling via systemic drug administration triggers conversion of white adipocytes into beige adipocytes (browning) and reduces adiposity. However, translation of this discovery into clinical practice is challenged by potential off-target side effects and lack of control over the location and temporal extent of beige adipocyte biogenesis. Here, we demonstrate an alternative approach to stimulate browning using nanoparticles (NPs) composed of FDA-approved poly(lactide-co-glycolide) that enable sustained local release of a Notch inhibitor (dibenzazepine, DBZ)...
June 15, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28623668/impact-of-pci-appropriateness-in-the-long-term-outcomes-of-consecutive-patients-treated-with-second-generation-drug-eluting-stents
#13
Ana Cristina Seixas, Amanda Sousa, Jose de Ribamar Costa, Adriana Costa Moreira, Ricardo Costa, Lucas Damiani, Cantídio Campos Neto, Galo Maldonado, Manuel Cano, J Eduardo Sousa
BACKGROUND: Appropriate use criteria (AUC) for coronary revascularization were developed to deliver high-quality care; however, the prognostic impact of these criteria remains unclear. We sought to assess the outcomes of patients treated with second-generation drug-eluting stent (DES) classified according to the updated American College of Cardiology Foundation/American Heart Association/Society for Cardiac Angiography and Intervention AUC for percutaneous coronary intervention (PCI)...
June 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28623588/design-of-knowledge-bases-for-plant-gene-regulatory-networks
#14
Eric Mukundi, Fabio Gomez-Cano, Wilberforce Zachary Ouma, Erich Grotewold
Developing a knowledge base that contains all the information necessary for the researcher studying gene regulation in a particular organism can be accomplished in four stages. This begins with defining the data scope. We describe here the necessary information and resources, and outline the methods for obtaining data. The second stage consists of designing the schema, which involves defining the entire arrangement of the database in a systematic plan. The third stage is the implementation, defined by actualization of the database by using software according to a predefined schema...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28619817/canoe-and-scribble-loss-synergizes-causing-tumor-like-overgrowth-via-ras-activation-in-neural-stem-cells-and-epithelia
#15
Noemí Rives-Quinto, Maribel Franco, Ana de Torres-Jurado, Ana Carmena
Over the past decade an intriguing connection between asymmetric cell division, stem cells and tumorigenesis has emerged. Neuroblasts, the neural stem cells of the Drosophila central nervous system, divide asymmetrically and constitute an excellent paradigm for further investigating that connection. Here we show that the simultaneous loss of the asymmetric cell division regulators Canoe (Afadin in mammals) and Scribble in neuroblast clones leads to tumor-like overgrowth through both a severe disruption of the asymmetric cell division process and a canoe loss-mediated Ras-PI3K-Akt activation...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28616843/intermittency-in-the-hodgkin-huxley-model
#16
Gaspar Cano, Rui Dilão
We show that action potentials in the Hodgkin-Huxley neuron model result from a type I intermittency phenomenon that occurs in the proximity of a saddle-node bifurcation of limit cycles. For the Hodgkin-Huxley spatially extended model, describing propagation of action potential along axons, we show the existence of type I intermittency and a new type of chaotic intermittency, as well as space propagating regular and chaotic diffusion waves. Chaotic intermittency occurs in the transition from a turbulent regime to the resting regime of the transmembrane potential and is characterised by the existence of a sequence of action potential spikes occurring at irregular time intervals...
June 14, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/28616368/correction-insights-of-the-dental-calculi-microbiome-of-pre-columbian-inhabitants-from-puerto-rico
#17
Tasha M Santiago-Rodriguez, Yvonne Narganes-Storde, Luis Chanlatte-Baik, Gary A Toranzos, Raul J Cano
[This corrects the article DOI: 10.7717/peerj.3277.].
2017: PeerJ
https://www.readbyqxmd.com/read/28614481/persistent-arthralgia-and-related-risks-factors-in-laboratory-confirmed-cases-of-chikungunya-virus-infection-in-mexico
#18
Efrén Murillo-Zamora, Oliver Mendoza-Cano, Benjamín Trujillo-Hernández, Ramón Alberto Sánchez-Piña, José Guzmán-Esquivel
Objective: To estimate the cumulative incidence of persistent arthralgia at 6 months from acute Chikungunya virus (CHIKV) infection and to evaluate the association of clinical markers with the risk of long-term arthralgia. Methods: This multicenter retrospective cohort study was conducted in the Mexican state of Colima. A total of 136 individuals aged 15 years and older with serologically confirmed CHIKV infection were enrolled. Participants were interviewed at 6 months from the onset of symptoms, and self-reported persistent arthralgia (PA) was the main binary outcome...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28612457/soluble-platinum-nanoparticles-ligated-by-long-chain-n-heterocyclic-carbenes-as-catalysts
#19
Luis M Martínez-Prieto, Lena Rakers, Angela M López-Vinasco, Israel Cano, Yannick Coppel, Karine Philippot, Frank Glorius, Bruno Chaudret, Piet W N M van Leeuwen
Soluble platinum nanoparticles (Pt NPs) ligated by two different long-chain N-Heterocyclic Carbenes (LC-IPr and LC-IMe) were synthesized and fully characterized by TEM, HRTEM, WAXS, XPS and solution NMR. The surface chemistry of these NPs (Pt@LC-IPr and Pt@LC-IMe) was investigated by FT-IR and solid state NMR using CO as a probe molecule. A clear influence of the bulkiness of the N-substituents was observed on the size, surface state and catalytic activity of these Pt NPs. While Pt@LC-IMe showed no activity in the hydroboration of phenylacetylene, Pt@LC-IPr revealed good selectivity for the trans-isomer which might be supported by a homogeneous species...
June 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28606880/spontaneous-rectus-sheath-haematoma
#20
Miguel F Carrascosa, María A Delgado-Tapia, Elena Casuso-Sáenz, Marta Cano-Hoz
No abstract text is available yet for this article.
July 2017: Lancet. Gastroenterology & Hepatology
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