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https://www.readbyqxmd.com/read/28619298/alternative-medicine-worker-health-and-absenteeism-in-the-united-states
#1
Kate Rybczynski
Health related absenteeism costs an estimated $153 billion annually in the United States (Witters and Agrawal, 2011).(1) Chronic conditions (major contributors to absenteeism) are often successfully managed by Complementary and Alternative Medicine (CAM). As CAM becomes an increasingly visible component of healthcare, firms may wish to consider whether CAM therapies can help reduce illness-related absenteeism. This paper aims to extend the literature on healthcare utilization and absenteeism by exploring whether CAM treatment is associated with fewer workdays missed due to illness...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28610844/overexpression-of-eif4f-components-in-meningiomas-and-suppression-of-meningioma-cell-growth-by-inhibiting-translation-initiation
#2
REVIEW
Janet L Oblinger, Sarah S Burns, Jie Huang, Li Pan, Yulin Ren, Rulong Shen, A Douglas Kinghorn, D Bradley Welling, Long-Sheng Chang
Meningiomas frequently display activation of the PI3K/AKT/mTOR pathway, leading to elevated levels of phospho-4E binding proteins, which enhances protein synthesis; however, it is not known whether inhibition of protein translation is an effective treatment option for meningiomas. We found that human meningiomas expressed high levels of the three components of the eukaryotic initiation factor 4F (eIF4F) translation initiation complex, eIF4A, eIF4E, and eIF4G. The expression of eIF4A and eIF4E was important in sustaining the growth of NF2-deficient benign meningioma Ben-Men-1 cells, as shRNA-mediated knockdown of these proteins strongly reduced cell proliferation...
June 10, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28601090/physical-health-related-quality-of-life-in-relation-to-metabolic-health-and-obesity-among-men-and-women-in-germany
#3
Julia Truthmann, Gert B M Mensink, Anja Bosy-Westphal, Ulfert Hapke, Christa Scheidt-Nave, Anja Schienkiewitz
BACKGROUND: This study examined sex-specific differences in physical health-related quality of life (HRQoL) across subgroups of metabolic health and obesity. We specifically asked whether (1) obesity is related to lower HRQoL independent of metabolic health status and potential confounders, and (2) whether associations are similar in men and women. METHODS: We used cross-sectional data from the German Health Interview and Examination Survey 2008-11. Physical HRQoL was measured using the Short Form-36 version 2 physical component summary (PCS) score...
June 10, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28598909/cardiorespiratory-reference-data-in-older-adults-the-generation-100-study
#4
Dorthe Stensvold, Silvana Bucher Sandbakk, Hallgeir Viken, Nina Zisko, Line Skarsem Reitlo, Javaid Nauman, Svein Erik Gaustad, Erlend Hassel, Marcel Moufack, Eivind Brønstad, Nils Petter Aspvik, Vegard Malmo, Sigurd Loe Steinshamn, Asbjørn Støylen, Sigmund Alfred Anderssen, Jorunn L Helbostad, Øivind Rognmo, Ulrik Wisløff
PURPOSE: Cardiorespiratory fitness (CRF) is regarded a clinical vital sign, and accurate reference values for all age groups are essential. Little data exist on CRF and cardiorespiratory function in older adults. The aim of this study was to provide normative values for CRF and cardiorespiratory function in older adults, including people with history of cardiovascular diseases. METHODS: In total, 1537 (769 women) participants aged 70-77 underwent clinical examinations and cardiopulmonary exercise tests...
June 9, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28592455/the-incidence-of-sudep-a-nationwide-population-based-cohort-study
#5
Olafur Sveinsson, Tomas Andersson, Sofia Carlsson, Torbjörn Tomson
OBJECTIVE: To identify all cases of sudden unexpected death in epilepsy (SUDEP) among people in Sweden during 1 year and to determine the SUDEP incidence in relation to age, sex, and psychiatric comorbidity. METHODS: We included all individuals with a hospital-based ambulatory care or hospital discharge diagnosis of epilepsy in the Swedish National Patient Registry during 1998-2005 who were alive on January 1, 2008. Deaths during 2008 were identified by linkage to the National Cause of Death Registry...
June 7, 2017: Neurology
https://www.readbyqxmd.com/read/28584650/are-men-under-treated-and-women-over-treated-with-antidepressants-findings-from-a-cross-sectional-survey-in-sweden
#6
Lena Thunander Sundbom, Kerstin Bingefors, Kerstin Hedborg, Dag Isacson
Aims and method To examine gender differences in self-reported depression and prescribed antidepressants (ADs). The Hospital Anxiety and Depression Scale was used to assess depression, and information on prescribed ADs was obtained from the Swedish Prescribed Drug Register. Results Depression was reported by 11.7% of the participants (12.3% men and 11.2% women). ADs were prescribed for 7.6% of the participants (5.3% men, 9.8% women). Among men, 1.8% reported depression and used ADs, 10.5% reported depression but did not use ADs, and 3...
June 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28581205/testing-radical-prostatectomy-in-men-with-prostate-cancer-and-oligometastases-to-the-bone-a-randomised-controlled-feasibility-trial
#7
Prasanna Sooriakumaran
Prostate cancer is the commonest cancer and the second most frequent cause of cancer death in Western men(1) . Men presenting with metastatic disease have a median survival of only 42.1 months(2) and current standard-of-care consists of initial androgen deprivation therapy (ADT) followed by chemotherapy and novel agents once the cancer no longer responds to ADT. The burden on the health care setting of treating men with metastatic prostate cancer is vast and a recent study estimated costs of USD20,000 per man(3) ...
June 5, 2017: BJU International
https://www.readbyqxmd.com/read/28567607/pancreatic-neuroendocrine-tumors-in-men1-disease-a-mono-centric-longitudinal-and-prognostic-study
#8
S Chiloiro, F Lanza, A Bianchi, G Schinzari, M G Brizi, A Giampietro, V Rufini, F Inzani, A Giordano, G Rindi, A Pontecorvi, L De Marinis
PURPOSE: Multiple endocrine neoplasia type 1 (MEN1) is an inherited endocrine neoplastic syndrome associated with a greater risk of endocrine tumor development like pancreatic neuroendocrine tumors (p-NET), with different clinical characteristics from sporadic ones. This paper aims to compare clinical, hystological and morphological aspects of p-NET in patients affected from MEN1 (MEN1+) and not-affected ones (MEN1-). METHODS: We performed a retrospective observational study...
May 31, 2017: Endocrine
https://www.readbyqxmd.com/read/28562685/gender-difference-in-relationship-between-serum-ferritin-and-25-hydroxyvitamin-d-in-korean-adults
#9
Jeong Min Seong, Yo Sang Yoon, Kyu Su Lee, Nan Young Bae, Mi Young Gi, Hyun Yoon
BACKGROUND: The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. METHODS: A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10...
2017: PloS One
https://www.readbyqxmd.com/read/28559776/association-between-serum-testosterone-and-psa-levels-in-middle-aged-healthy-men-from-the-general-population
#10
Saad Elzanaty, Babak Rezanezhad, Gert Dohle
INTRODUCTION: The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population. MATERIALS AND METHODS: Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal (testosterone > 12 nmol/l)...
April 2017: Current Urology
https://www.readbyqxmd.com/read/28554736/heat-transfer-and-loss-by-whole-body-hyperthermia-during-severe-lower-body-heating-are-impaired-in-healthy-older-men
#11
Marius Brazaitis, Henrikas Paulauskas, Nerijus Eimantas, Diana Obelieniene, Neringa Baranauskiene, Albertas Skurvydas
Most studies demonstrate that aging is associated with a weakened thermoregulation. However, it remains unclear whether heat transfer (for heat loss) from the lower (uncompensable) to the upper (compensable) body during passively-induced severe lower-body heating is delayed or attenuated with aging. Therefore, the main purpose of this study was to investigate heat transfer from uncompensable to compensable body areas in young men and healthy older men during passively-induced whole-body hyperthermia with a demonstrated post-heating change in core body (rectal; Tre) temperature...
May 26, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28552950/genomic-profile-of-human-meningioma-cell-lines
#12
Yu Mei, Wenya Linda Bi, Noah F Greenwald, Nathalie Y Agar, Rameen Beroukhim, Gavin P Dunn, Ian F Dunn
Meningiomas, derived from arachnoid cap cells, are the most common intracranial tumor. High-grade meningiomas, as well as those located at the skull base or near venous sinuses, frequently recur and are challenging to manage. Next-generation sequencing is identifying novel pharmacologic targets in meningiomas to complement surgery and radiation. However, due to the lack of in vitro models, the importance and implications of these genetic variants in meningioma pathogenesis and therapy remain unclear. We performed whole exome sequencing to assess single nucleotide variants and somatic copy number variants in four human meningioma cell lines, including two benign lines (HBL-52 and Ben-Men-1) and two malignant lines (IOMM-Lee and CH157-MN)...
2017: PloS One
https://www.readbyqxmd.com/read/28542366/illicit-drug-use-and-its-association-with-key-sexual-risk-behaviours-and-outcomes-findings-from-britain-s-third-national-survey-of-sexual-attitudes-and-lifestyles-natsal-3
#13
Rachelle Paquette, Clare Tanton, Fiona Burns, Philip Prah, Maryam Shahmanesh, Nigel Field, Wendy Macdowall, Kirsten Gravningen, Pam Sonnenberg, Catherine H Mercer
OBJECTIVES: We explore the hypothesis that using illicit drugs other than, or in addition to, cannabis is associated with sexual risk behaviour and sexual health outcomes in the British population. METHODS: We analysed data, separately by gender, reported by sexually-active participants (those reporting > = 1 partners/past year) aged 16-44 years (3,395 men, 4,980 women) in Britain's third National Survey of Sexual Attitudes and Lifestyles (Natsal-3), a probability survey undertaken 2010-12 involving computer-assisted personal-interview and computer-assisted self-interview...
2017: PloS One
https://www.readbyqxmd.com/read/28538302/physiological-demands-of-elite-cross-country-skiing-during-a-real-competition
#14
Cristina Gonzalez-Millan, Dario Perez-Brunicardi, Juan J Salinero, Beatriz Lara, Javier Abián-Vicen, Francisco Areces, Diana Ruiz-Vicente, Lidon Soriano, Juan Del Coso
The aim of this study was to assess different physiological variables before and after a 5-km (women) and 10-km (men) cross-country skiing competition to determine potential mechanisms of fatigue. Fourteen elite-level skiers competed in an official cross-country skiing competition using the classical style (9 men and 5 women). Instantaneous skiing velocity was measured during the race by means of 15-Hz global positioning system devices. Before and after the race, a sample of venous blood was obtained to assess changes in blood lactate and serum electrolyte and myoglobin concentrations...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28525993/translation-and-validation-of-the-finnish-version-of-index-of-dental-anxiety-and-fear-idaf-4c-%C3%A2-among-dental-students
#15
Mimmi Tolvanen, Katri Puijola, Jason M Armfield, Satu Lahti
BACKGROUND: Dental fear accounts for 41% of the non-habitual dental attendance such as visiting only when in pain among adult Finns. Dentists should be able to recognize patients in risk for irregular attendance due to dental fear and measure their fear with valid and reliable instrument that capture the multidimensionality of dental fear. The study's aim was to translate the Index of Dental Anxiety and Fear (IDAF-4C+) into Finnish and test its reliability and validity. METHODS: The study population consisted of dental students in a Finnish university (n = 202)...
May 19, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28515070/even-mealtime-distribution-of-protein-intake-is-associated-with-greater-muscle-strength-but-not-with-3-y-physical-function-decline-in-free-living-older-adults-the-quebec-longitudinal-study-on-nutrition-as-a-determinant-of-successful-aging-nuage-study
#16
Samaneh Farsijani, Hélène Payette, José A Morais, Bryna Shatenstein, Pierrette Gaudreau, Stéphanie Chevalier
Background: Functional status declines with aging, thus impeding autonomy. Recently, a more even mealtime distribution of dietary protein was positively associated with muscle mass, but the relation of this distribution to physical performance remains unknown.Objective: We examined the relation between mealtime protein-intake distribution and physical performance and its 3-y decline in community-dwelling older adults.Design: Three-year follow-up data from 827 men and 914 women (67-84 y) in the longitudinal study on nutrition and aging [Quebec longitudinal study on Nutrition as a Determinant of Successful Aging (NuAge study); Quebec, Canada] were analyzed...
May 17, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28511726/executive-functioning-in-pedophilia-and-child-sexual-offending
#17
Claudia Massau, Gilian Tenbergen, Christian Kärgel, Simone Weiß, Hannah Gerwinn, Alexander Pohl, Till Amelung, Sebastian Mohnke, Jonas Kneer, Matthias Wittfoth, Inka Ristow, Kolja Schiltz, Klaus M Beier, Jorge Ponseti, Martin Walter, Tillmann H C Kruger, Henrik Walter, Boris Schiffer
OBJECTIVES: Pedophilia (P) is a psychiatric disease associated with sexual attraction toward children and often accompanied by child sexual offending (CSO). Consequently, it is important to address the understanding of executive dysfunctions that may increase the probability of CSO. Moreover, this research field has been lacking to disentangle executive deficits associated with pedophilia (as a deviant sexual preference) from those associated with CSO (as a deviant sexual behavior). METHODS: The German multi-sided research network NeMUP offers the opportunity to overcome these limitations...
May 17, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28506980/sex-differences-in-trajectories-of-risk-after-rehospitalization-for-heart-failure-acute-myocardial-infarction-or-pneumonia
#18
Rachel P Dreyer, Kumar Dharmarajan, Angela F Hsieh, John Welsh, Li Qin, Harlan M Krumholz
BACKGROUND: Women have an increased risk of rehospitalization in the immediate postdischarge period; however, few studies have determined how readmission risk dynamically changes on a day-to-day basis over the full year after hospitalization by sex and how these differences compare with the risk for mortality. METHODS AND RESULTS: We identified >3 000 000 hospitalizations of patients with a principal discharge diagnosis of heart failure, acute myocardial infarction, or pneumonia and estimated sex differences in the daily risk of rehospitalization/death 1 year after discharge from a population of Medicare fee-for-service beneficiaries aged 65 years and older...
May 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28493484/cytoplasmic-overexpression-of-rna-binding-protein-hur-is-a-marker-of-poor-prognosis-in-meningioma-and-hur-knockdown-decreases-meningioma-cell-growth-and-resistance-to-hypoxia
#19
Guillaume Gauchotte, Sébastien Hergalant, Charlène Vigouroux, Jean-Matthieu Casse, Rémi Houlgatte, Tony Kaoma, Déborah Helle, Lydia Brochin, Fabien Rech, Matthieu Peyre, François Labrousse, Laurent Vallar, Jean-Louis Gueant, Jean-Michel Vignaud, Shyue-Fang Battaglia-Hsu
HuR regulates cytoplasmic mRNA stability and translatability, and the HuR expression level has been shown to correlate with poor disease outcome in several cancer types; however, the prognostic value and potential pro-oncogenic properties of HuR in meningioma remain unclear. Thus, in the present study we analyzed 85 meningioma tissue samples to establish the relationship between HuR expression, tumor-cell proliferation, and/or patient survival. In addition, we examined the anti-proliferative effects of HuR knockdown in two meningioma cell lines (IOMM-Lee and Ben-Men1), and conducted transcriptome-wide analyses (IOMM-Lee cells) to elucidate the molecular consequences of HuR knockdown...
May 11, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28492924/handheld-reflectance-confocal-microscopy-for-the-detection-of-recurrent-extramammary-paget-disease
#20
Oriol Yélamos, Brian P Hibler, Miguel Cordova, Travis J Hollmann, Kivanc Kose, Michael A Marchetti, Patricia L Myskowski, Melissa P Pulitzer, Milind Rajadhyaksha, Anthony M Rossi, Manu Jain
Importance: Extramammary Paget disease (EMPD) is commonly refractory to surgical and nonsurgical therapies. Identifying recurrent or persistent EMPD is challenging because the disease is multifocal, and multiple blind scouting biopsies are usually performed in this setting. Handheld reflectance confocal microscopy (HRCM) has been used to diagnose and map primary EMPD and therefore may be used to identify EMPD recurrences. Objective: To evaluate HRCM's diagnostic accuracy in the setting of recurrent or persistent EMPD as well as its potential diagnostic pitfalls...
May 10, 2017: JAMA Dermatology
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