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https://www.readbyqxmd.com/read/28814219/coeliac-disease-review-of-diagnosis-and-management
#1
Marjorie M Walker, Jonas F Ludvigsson, David S Sanders
Coeliac disease is an immune-mediated systemic disease triggered by exposure to gluten, and manifested by small intestinal enteropathy and gastrointestinal and extra-intestinal symptoms. Recent guidelines recommend a concerted use of clear definitions of the disease. In Australia, the most recent estimated prevalence is 1.2% in adult men (1:86) and 1.9% in adult women (1:52). Active case finding is appropriate to diagnose coeliac disease in high risk groups. Diagnosis of coeliac disease is important to prevent nutritional deficiency and long term risk of gastrointestinal malignancy...
August 21, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28810857/new-onset-diabetes-in-adulthood-is-associated-with-a-substantial-risk-for-mortality-at-all-ages-a-population-based-historical-cohort-study-with-a-decade-long-follow-up
#2
Inbar Zucker, Tamy Shohat, Rachel Dankner, Gabriel Chodick
BACKGROUND: Diabetes has been reported to be associated with an increased relative risk for mortality, with estimates ranging from 1.1 to 2.1. Findings are inconsistent regarding modification of the risk by gender and by age. The aim of this study was to estimate the mortality risk associated with new-onset diabetes in adulthood, by age group and gender. METHODS: From the database of a large health care provider, we identified 31,987 individuals diagnosed with diabetes during 2003-2005; and 162,656 individuals without diabetes, group-matched by age...
August 15, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28808790/health-risks-in-the-cleaning-industry-a-belgian-census-linked-mortality-study-1991-2011
#3
Laura Van den Borre, Patrick Deboosere
PURPOSE: Cleaning work has been associated with a wide range of occupational health hazards. However, little is known about mortality risks in the cleaning industry. This study examines differences in cause-specific mortality between cleaners, manual and non-manual workers. METHODS: Using exhaustive census-linked mortality data, the total Belgian working population aged 30-60 was selected from the 1991 census. Analyses were based on 202,339 male and 58,592 female deaths between 1 March 1991 and 31 December 2011...
August 14, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28800303/does-gender-make-a-difference-in-knee-rotation-proprioception-and-range-of-motion-in-healthy-subjects
#4
Qassim I Muaidi
BACKGROUND: Knee proprioception is an integral component of neuromuscular control system that stabilizes the joints, reducing incidence of injury. Knee injuries' incidences differ between genders. Knee rotation is a component of different knee injury mechanisms. Gender differences in knee proprioception in internal (IR) and external (ER) rotations are not sufficiently studied. OBJECTIVE: To check whether proprioceptive acuity in IR and ER directions of knee rotation is inherently lower in women compared to men...
August 1, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28792638/transmission-of-type-2-diabetes-to-sons-and-daughters-the-d-e-s-i-r-cohort
#5
B Balkau, R Roussel, S Wagner, J Tichet, P Froguel, G Fagherazzi, F Bonnet
AIMS: To document the family transmission of Type 2 diabetes to men and women. METHOD: The French D.E.S.I.R. cohort followed men and women over 9 years, with 3-yearly testing for incident Type 2 diabetes. First- and/or second-degree family histories of diabetes were available for 2187 men and 2282 women. Age-adjusted hazard ratios were estimated for various family members and groupings of family members, as well as for a genetic diabetes risk score, based on 65 diabetes-associated loci...
August 9, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28789721/sociodemographic-lifestyle-and-behavioural-factors-associated-with-consumption-of-sweetened-beverages-among-adults-in-cambridgeshire-uk-the-fenland-study
#6
Peter Barrett, Fumiaki Imamura, Søren Brage, Simon J Griffin, Nicholas J Wareham, Nita G Forouhi
OBJECTIVE: We aimed to identify sociodemographic, lifestyle and behavioural determinants of consumption of sugar-sweetened beverages (SSB) and artificially sweetened beverages (ASB) among adults in Cambridgeshire, UK. DESIGN: Cross-sectional data were obtained from a cohort of 9991 adults born between 1950 and 1975. An FFQ was used to assess consumption of beverages and other dietary factors. Multivariable logistic regression was used to examine potential determinants of consuming SSB and ASB (≥1 serving/d)...
August 9, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28782403/spillover-improved-survival-in-non-invited-patients-of-the-colorectal-cancer-screening-programme
#7
Joonas Miettinen, Nea Malila, Matti Hakama, Janne Pitkäniemi
Objectives In colorectal cancer screening, randomized clinical trials have shown a 16% mean reduction in colorectal cancer mortality, but the Finnish randomized health services study showed no effect. We quantified spillover (the total indirect effect caused by the programme on the non-invited) and corrected the effectiveness estimate of the Finnish programme. Methods We retrieved from the Finnish Cancer Registry data on all non-invited colorectal cancer patients diagnosed in 1999-2013 in municipalities that adopted screening ( n = 18,948)...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28782321/insulinoma-presenting-with-neuropsychiatric-symptoms
#8
S Aggarwal, N Nand, N Damle, R Godara, R Kumar
An insulinoma is a rare pancreatic endocrine tumor which is typically a hypervascular, solitary small tumour. 90 % of tumors are benign and less than 2 cm in size. Some insulinomas are associated with MEN-1 syndrome. Some cases of insulinoma may present with neuropsychiatric symptoms and may be wrongly diagnosed as psychosis. We report a case of insulinoma in a 55 years old female who presented with episodes of abnormal behavior and altered sensorium. On detailed investigations she was diagnosed as a case of hyperinsulinemic hypoglycemia due to insulinoma (in her case MRI abdomen was normal) DOTANOC PET CT confirmed the insulinoma in body/tail of pancreas...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28775133/italian-pool-of-asbestos-workers-cohorts-mortality-trends-of-asbestos-related-neoplasms-after-long-time-since-first-exposure
#9
Daniela Ferrante, Elisabetta Chellini, Enzo Merler, Venere Pavone, Stefano Silvestri, Lucia Miligi, Giuseppe Gorini, Vittoria Bressan, Paolo Girardi, Laura Ancona, Elisa Romeo, Ferdinando Luberto, Orietta Sala, Corrado Scarnato, Simona Menegozzo, Enrico Oddone, Sara Tunesi, Patrizia Perticaroli, Aldo Pettinari, Francesco Cuccaro, Stefano Mattioli, Antonio Baldassarre, Francesco Barone-Adesi, Tiziana Cena, Patrizia Legittimo, Alessandro Marinaccio, Dario Mirabelli, Marina Musti, Roberta Pirastu, Alessandra Ranucci, Corrado Magnani
OBJECTIVE: Asbestos is a known human carcinogen, with evidence for malignant mesothelioma (MM), cancers of lung, ovary, larynx and possibly other organs. MM rates are predicted to increase with a power of time since first exposure (TSFE), but the possible long-term attenuation of the trend is debated. The asbestos ban enforced in Italy in 1992 gives an opportunity to measure long-term cancer risk in formerly exposed workers. METHODS: Pool of 43 previously studied Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding), with mortality follow-up updated to 2010...
August 3, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28760748/impact-of-age-sex-and-body-mass-index-on-cortisol-secretion-in-143-healthy-adults
#10
Ferdinand Roelfsema, D van Heemst, Ali Iranmanesh, Paul Y Takahashi, Rebecca Yang, Johannes D Veldhuis
CONTEXT: Studies on 24-h cortisol secretion are rare. The impact of sex, age and adiposity on cortisol levels, often restricted to one or a few samples, are well recognized, but conflicting. OBJECTIVE: To investigate cortisol dynamics in 143 healthy men and women, spanning 7 decades and with a 2-fold body mass index (BMI) range with different analytic tools. SETTING: Clinical Research Unit. DESIGN: Cortisol concentrations in 10-min samples collected for 24 h...
July 31, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28743793/animal-models-of-men-1
#11
Hermine Mohr, Natalia S Pellegata
Animal models of cancer have been instrumental in advancing our understanding of the biology of tumor initiation and progression, in studying gene function, and in performing preclinical studies aimed at testing novel therapies. Several animal models of the MEN1 syndrome have been generated in different organisms by introducing loss-of-function mutations in the orthologues of the human MEN1 gene. In this review, we will discuss MEN1 and MEN1-like models in Drosophila, mice and rats. These model systems with their specific advantages and limitations have contributed to elucidate the function of Menin in tumorigenesis, which turned out to be remarkably conserved from flies to mammals, as well as the biology of the disease...
July 25, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28742078/longitudinal-changes-in-glucocorticoid-receptor-exon-1f-methylation-and-psychopathology-after-military-deployment
#12
R R Schür, M P Boks, B P F Rutten, N P Daskalakis, L de Nijs, M van Zuiden, A Kavelaars, C J Heijnen, M Joëls, R S Kahn, E Geuze, E Vermetten, C H Vinkers
Several cross-sectional studies have demonstrated the relevance of DNA methylation of the glucocorticoid receptor exon 1F region (GR-1F) for trauma-related psychopathology. We conducted a longitudinal study to examine GR-1F methylation changes over time in relation to trauma exposure and the development of post-deployment psychopathology. GR-1F methylation (52 loci) was quantified using pyrosequencing in whole blood of 92 military men 1 month before and 6 months after a 4-month deployment period to Afghanistan...
July 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28737591/hiv-incidence-and-predictors-of-hiv-acquisition-from-an-outside-partner-in-serodiscordant-couples-in-lusaka-zambia-1995-2012
#13
Dvora L Joseph Davey, Kristin M Wall, William Kilembe, Htee Khu Naw, Ilene Brill, Bellington Vwalika, Elwyn Chomba, Joseph Mulenga, Amanda Tichacek, Marjan Javanbakt, Pamina Gorbach, Susan Allen
OBJECTIVE: Evaluate the incidence and predictors of HIV acquisition from outside partners in serodiscordant couples. METHODS: Demographic, behavioral, and clinical exposures were measured quarterly in a cohort of serodiscordant cohabiting couples in Zambia from 1995-2012 (n=3049). Genetic analysis classified incident infections as those acquired from the study partner (linked) or acquired from an outside partner (unlinked). Factors associated with time to unlinked HIV infection were evaluated using multivariable Cox proportional hazards regression stratified by gender...
July 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28727762/sexual-diversity-in-the-united-states-results-from-a-nationally-representative-probability-sample-of-adult-women-and-men
#14
Debby Herbenick, Jessamyn Bowling, Tsung-Chieh Jane Fu, Brian Dodge, Lucia Guerra-Reyes, Stephanie Sanders
In 2015, we conducted a cross-sectional, Internet-based, U.S. nationally representative probability survey of 2,021 adults (975 men, 1,046 women) focused on a broad range of sexual behaviors. Individuals invited to participate were from the GfK KnowledgePanel®. The survey was titled the 2015 Sexual Exploration in America Study and survey completion took about 12 to 15 minutes. The survey was confidential and the researchers never had access to respondents' identifiers. Respondents reported on demographic items, lifetime and recent sexual behaviors, and the appeal of 50+ sexual behaviors...
2017: PloS One
https://www.readbyqxmd.com/read/28722206/alcohol-consumption-and-risk-of-urothelial-cell-bladder-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-cohort
#15
E Botteri, P Ferrari, N Roswall, A Tjønneland, A Hjartåker, J M Huerta, R T Fortner, A Trichopoulou, A Karakatsani, C La Vecchia, V Pala, A Perez-Cornago, E Sonestedt, F Liedberg, K Overvad, M J Sánchez, I T Gram, M Stepien, L Trijsburg, L Börje, M Johansson, T Kühn, S Panico, R Tumino, H B Bueno-de-Mesquita, E Weiderpass
Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35-70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits)...
July 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28718171/younger-patients-and-men-achieve-higher-outcome-scores-than-older-patients-and-women-after-anterior-cruciate-ligament-reconstruction
#16
Kate E Webster, Julian A Feller
BACKGROUND: There is some evidence that functional performance and validated outcome scores differ according to the gender, age, and sport participation status of a patient after anterior cruciate ligament (ACL) reconstruction. However, the impact of these three factors, and interaction among them, has not been studied across a large relatively homogeneous group of patients to better elucidate their impact. QUESTIONS/PURPOSES: We reviewed a large cohort of patients who had undergone ACL reconstruction to determine if ROM, knee laxity, objective performance measures, and validated outcome scores differed according to (1) gender; (2) age; and (3) sport participation status...
July 17, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28718071/cancer-survival-in-adult-patients-in-spain-results-from-nine-population-based-cancer-registries
#17
M D Chirlaque, D Salmerón, J Galceran, A Ameijide, A Mateos, A Torrella, R Jiménez, N Larrañaga, R Marcos-Gragera, E Ardanaz, M Sant, P Minicozzi, C Navarro, M J Sánchez
INTRODUCTION: With the aim of providing cancer control indicators, this work presents cancer survival in adult (≥15 years) patients in Spain diagnosed during the period 2000-2007 from Spanish cancer registries participating in the EUROCARE project. METHODS: Cancer cases from nine Spanish population-based cancer registries were included and analysed as a whole. All primary malignant neoplasms diagnosed in adult patients were eligible for the analysis. Cancer patients were followed until 31 December 2008...
July 17, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28706426/healthcare-utilization-and-costs-associated-with-gastroparesis
#18
Vaibhav Wadhwa, Dhruv Mehta, Yash Jobanputra, Rocio Lopez, Prashanthi N Thota, Madhusudhan R Sanaka
AIM: To use a national database of United States hospitals to evaluate the incidence and costs of hospital admissions associated with gastroparesis. METHODS: We analyzed the National Inpatient Sample Database (NIS) for all patients in whom gastroparesis (ICD-9 code: 536.3) was the principal discharge diagnosis during the period, 1997-2013. The NIS is the largest publicly available all-payer inpatient care database in the United States. It contains data from approximately eight million hospital stays each year...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28689987/risk-factors-associated-with-atherogenic-dyslipidemia-in-the-presence-of-optimal-statin-therapy
#19
Wang Zhao, Xi-Long Zheng, Ze-Nan Jiang, Xiao-Bo Liao, Shui-Ping Zhao
BACKGROUND: This study investigated the prevalence of atherogenic dyslipidemia (AD) in Chinese outpatients whose low-density lipoprotein cholesterol (LDL-C) levels reached the goals with statin monotherapy and evaluated the characteristics of these patients. METHODS: An analysis of the Dyslipidemia International Survey-China study that was carried out at 122 hospitals in China. Among patients reaching their LDL-C goals, the presence of AD was defined as triglyceride levels ≥1...
June 30, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28680318/clinical-electrophysiological-and-serological-evaluation-of-patients-with-cramp-fasciculation-syndrome
#20
Mürüvvet Poyraz, Zeliha Matur, Fikret Aysal, Erdem Tüzün, Lütfü Hanoğlu, A Emre Öge
INTRODUCTION: Cramp-fasciculation syndrome (CFS) is a rare peripheral nerve hyperexcitability syndrome. There are only a few reports on clinical and serological profile of a CFS cohort that was followed up by a single outpatient clinic. METHODS: Clinical, electrophysiological, and serological features of 6 CFS patients (5 men, 1 woman; 27-65 years old) were investigated. RESULTS: All patients presented with cramps, fasciculations, muscle pain, and autonomic symptoms, and 2 also reported numbness and burning sensation in limbs, suggestive of neuropathic pain...
June 2017: Noro Psikiyatri Arsivi
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