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https://www.readbyqxmd.com/read/29904645/infection-triggered-autoimmunity-the-case-of-herpes-simplex-virus-type-1-and-anti-nmdar-antibodies
#1
EDITORIAL
Russell C Dale, Margherita Nosadini
No abstract text is available yet for this article.
July 2018: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/29902492/analytical-validation-of-viral-cns-flow-chip-kit-for-detection-of-acute-meningitis-and-encephalitis
#2
Mercedes Pérez-Ruiz, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Cristina Gómez-Camarasa, José María Navarro-Marí
A new molecular assay (Viral CNS Flow Chip kit, Master Diagnóstica, Spain) has been developed for the detection of eight viruses causing acute meningitis and encephalitis, i.e. herpes simplex viruses 1-2, varicella zoster virus, human enterovirus, human parechovirus, Toscana virus, human cytomegalovirus and Epstein Barr virus. The new assay is a multiplex one-step RT-PCR followed by automatic flow-through hybridization, colorimetric detection and image analysis. The limit of detection was 50 copies/reaction, and 10 copies/reaction for human enterovirus and the other seven viruses, respectively...
June 11, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29900087/fulminant-herpes-simplex-virus-type-i-encephalitis-despite-maximal-medical-therapy
#3
Nakul Katyal, Ather M Taqui, Deborah Tepper, Jonathan M Beary, Christopher R Newey
Herpes simplex-1 virus encephalitis (HSE) is the most commonly recognized cause of sporadic encephalitis in the United States. Historically HSE has been considered extremely detrimental given the associated relentless neurological deterioration secondary to cerebral edema and status epilepticus. With recent advances in antiviral therapeutics in past decades, the majority of complications can be managed effectively although the associated morbidity and mortality still remains high. The key modifiable factor determining recovery is the rapid initiation of antiviral therapy...
April 12, 2018: Curēus
https://www.readbyqxmd.com/read/29899553/ubxn3b-positively-regulates-sting-mediated-antiviral-immune-responses
#4
Long Yang, Leilei Wang, Harshada Ketkar, Jinzhu Ma, Guang Yang, Shuang Cui, Tingting Geng, Dana G Mordue, Toyoshi Fujimoto, Gong Cheng, Fuping You, Rongtuan Lin, Erol Fikrig, Penghua Wang
The ubiquitin regulatory X domain-containing proteins (UBXNs) are likely involved in diverse biological processes. Their physiological functions, however, remain largely unknown. Here we present physiological evidence that UBXN3B positively regulates stimulator-of-interferon genes (STING) signaling. We employ a tamoxifen-inducible Cre-LoxP approach to generate systemic Ubxn3b knockout in adult mice as the Ubxn3b-null mutation is embryonically lethal. Ubxn3b-/- , like Sting-/- mice, are highly susceptible to lethal herpes simplex virus 1 (HSV-1) and vesicular stomatitis virus (VSV) infection, which is correlated with deficient immune responses when compared to Ubxn3b+/+ littermates...
June 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/29899106/regulation-of-herpes-simplex-virus-2-protein-kinase-ul13-by-phosphorylation-and-its-role-in-viral-pathogenesis
#5
Naoto Koyanagi, Akihisa Kato, Kosuke Takeshima, Yuhei Maruzuru, Hiroko Kozuka-Hata, Masaaki Oyama, Jun Arii, Yasushi Kawaguchi
UL13 proteins are serine/threonine protein kinases encoded by herpes simplex virus HSV-1 and HSV-2. Although the downstream effects of the HSV protein kinases, mostly those of HSV-1 UL13, have been reported, there is a lack of information on how these viral protein kinases are regulated in HSV-infected cells. In this study, we used a large-scale phosphoproteomic analysis of HSV-2-infected cells to identify a physiological phosphorylation site in HSV-2 UL13 (i.e., Ser-18), and investigated the significance of phosphorylation of this site in HSV-2-infected cell cultures and mice...
June 13, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29899087/human-asymptomatic-epitope-peptide-cxcl10-based-prime-pull-vaccine-induces-herpes-simplex-virus-specific-gamma-interferon-positive-cd107-cd8-t-cells-that-infiltrate-the-cornea-and-trigeminal-ganglia-of-humanized-hla-transgenic-rabbits-and-protect-against-ocular
#6
Arif A Khan, Ruchi Srivastava, Hawa Vahed, Soumyabrata Roy, Sager S Walia, Grace J Kim, Mona A Fouladi, Taikun Yamada, Vincent T Ly, Cynthia Lam, Anthony Lou, Vivianna Nguyen, Undariya Boldbaatar, Roger Geertsema, Nigel W Fraser, Lbachir BenMohamed
Herpes simplex virus 1 (HSV-1) is a prevalent human pathogen that infects the cornea causing potentially blinding herpetic disease. A clinical herpes vaccine is still lacking. In the present study, a novel prime/pull vaccine was tested in Human Leukocyte Antigen- (HLA-) transgenic rabbit model of ocular herpes (HLA Tg rabbit). Three asymptomatic (ASYMP) peptide epitopes were selected from the HSV-1 membrane glycoprotein C (UL44400-408 ), the DNA replication binding helicase (UL9196-204 ), and the tegument protein (UL25572-580 ), all preferentially recognized by CD8+ T cells from "naturally protected" HSV-1-seropositive healthy ASYMP individuals (who never had recurrent corneal herpetic disease)...
June 13, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29898986/ultrasensitive-capture-of-human-herpes-simplex-virus-genomes-directly-from-clinical-samples-reveals-extraordinarily-limited-evolution-in-cell-culture
#7
Alexander L Greninger, Pavitra Roychoudhury, Hong Xie, Amanda Casto, Anne Cent, Gregory Pepper, David M Koelle, Meei-Li Huang, Anna Wald, Christine Johnston, Keith R Jerome
Herpes simplex viruses (HSVs) are difficult to sequence due to their large DNA genome, high GC content, and the presence of repeats. To date, most HSV genomes have been recovered from culture isolates, raising concern that these genomes may not accurately represent circulating clinical strains. We report the development and validation of a DNA oligonucleotide hybridization panel to recover nearly complete HSV genomes at abundances up to 50,000-fold lower than previously reported. Using copy number information on herpesvirus and host DNA background via quantitative PCR, we developed a protocol for pooling for cost-effective recovery of more than 50 HSV-1 or HSV-2 genomes per MiSeq run...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29896662/us3-protein-kinase-encoded-by-hsv-the-precise-function-and-mechanism-on-viral-life-cycle
#8
Akihisa Kato, Yasushi Kawaguchi
All members of the Alphaherpesvirinae subfamily encode a serine/threonine kinase, designated Us3, which is not conserved in the other subfamilies. Us3 is a significant virulence factor for herpes simplex virus type 1 (HSV-1), which is one of the best-characterized members of the Alphaherpesvirinae family. Accumulating evidence indicates that HSV-1 Us3 is a multifunctional protein that plays various roles in the viral life cycle by phosphorylating a number of viral and cellular substrates. Therefore, the identification of Us3 substrates is directly connected to understanding Us3 functions and mechanisms...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29893649/non-small-cell-lung-cancer-feasibility-of-intratumoral-radiofrequency-hyperthermia-enhanced-herpes-simplex-virus-thymidine-kinase-gene-therapy
#9
Jiansong Ji, Qiaoyou Weng, Feng Zhang, Fu Xiong, Yin Jin, Junguo Hui, Jingjing Song, Jun Gao, Minjiang Chen, Qiang Li, David Shin, Xiaoming Yang
Purpose To validate the feasibility and efficacy of intratumoral radiofrequency hyperthermia (RFH)-enhanced herpes simplex virus (HSV) thymidine kinase (TK) and ganciclovir (GCV) (hereafter, HSV-TK/GCV) gene therapy for non-small-cell lung cancer (NSCLC). Materials and Methods This study was performed from November 11, 2015, to April 14, 2017, and included (a) in vitro experiments with human NSCLC cells to establish the proof of principle, (b) in vivo experiments using mice with subcutaneous NSCLC to further demonstrate the principle, and (c) in vivo experiments using rats with orthotopic NSCLC to validate the technical feasibility...
June 12, 2018: Radiology
https://www.readbyqxmd.com/read/29892642/-in-silico-prediction-of-cellular-gene-targets-of-herpesvirus-encoded-micrornas
#10
Afsar R Naqvi, Alexandra Seal, Jennifer Shango, Deepak Shukla, Salvador Nares
Herpesviruses have evolved to encode multiple microRNAs [viral miRNAs (v-miRs)], a unique feature of this family of double stranded DNA (dsDNA) viruses. However, functional role of these v-miRs in host-pathogen interaction remains poorly studied. In this data, we examined the impact of oral disease associated v-miRs viz ., miR-H1 [encoded by herpes simplex virus 1 (HSV1)] and miR-K12-3 [encoded by Kaposi sarcoma-associated herpesvirus (KSHV)] by identifying putative targets of viral miRNAs. We used our published microarray data (GSE107005) to identify the transcripts downregulated by the v-miRs...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29889472/a-case-with-angiographic-demonstration-of-isolated-anterior-spinal-artery-occlusion
#11
Vasfiye Burcu Dogan, Batuhan Kara, Hakan Hatem Selcuk, Ayten Ceyhan Dirican, Ayhan Koksal
Anterior spinal artery syndrome (ASAS) is a rare syndrome which occurs due to thrombosis of anterior spinal artery (ASA) which supplies anterior two thirds of the spinal cord. A 27-year-old female patient was admitted to emergency clinic with sudden onset neck pain, sensory loss and weakness in proximal upper extremities which occurred at rest. Thrombophilia assessment tests were negative. Echocardiography was normal. Serum viral markers were negative. In cerebrospinal fluid (CSF) examination, cell count and biochemistry was normal, oligoclonal band was negative, viral markers for herpes simplex virus (HSV) type-1 and type-2, Brucella, Borrellia, Treponema pallidum, Tuberculosis were negative...
March 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29889070/herpes-viruses-and-senile-dementia-first-population-evidence-for-a-causal-link
#12
Ruth F Itzhaki, Richard Lathe
Three articles have very recently appeared that are of especial relevance to the causes of dementia and its potential treatment. The first two (Tsai et al., published in PLoS One in November 2017; Chen et al., published in the January/February 2018 issue of Journal of Clinical Psychiatry) demonstrate an increased risk of subsequent senile dementia (SD) development in patients with acute varicella zoster (herpes zoster) infection. These articles present data highly relevant to the third, and most important, paper-by Tzeng et al...
June 4, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29888926/features-and-outcomes-of-immunoglobulin-therapy-in-patients-with-good-syndrome-at-thailand-s-largest-tertiary-referral-hospital
#13
Torpong Thongngarm, Adhiratha Boonyasiri, Panitan Pradubpongsa, Nattaporn Tesavibul, Tauangtham Anekpuritanang, Piyawut Kreetapirom, Mongkhon Sompornrattanaphan
BACKGROUND: Good syndrome (GS) is an adult-onset immunodeficiency characterized by coexisting thymoma and hypogammaglobulinemia. Clinical course after treatment with intravenous immunoglobulin (IVIg) has rarely been reported. OBJECTIVE: To investigate and report the clinical course and outcomes of GS patients after treatment with IVIg at Thailand's largest national tertiary referral hospital METHODS: This retrospective chart review included patients diagnosed with GS and treated with IVIg during the 1 January 2005 to 31 December 2015 study period...
June 11, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29883346/the-study-of-leukocyte-phagocytic-activity-in-the-presence-of-herpetic-infection-and-stroke
#14
Natalia V Motorna, Svetlana L Rybalko, Daria B Starosyla, Mykhailo M Guzyk, Iryna G Strokina, Rostyslav F Kaminsky, Alina V Korsak, Sergey I Savosko, Liudmyla M Sokurenko, Yurii B Chaikovsky
OBJECTIVE: Inrtoduction: Post-stroke complications are one of the urgent and insufficiently resolved problems. According to different literature data 23% to 65% of patients suffer from the post-stroke development of an infectious process. Herpes simplex virus type 1 and 2 can also be etiological factors of stroke development, however their reactivation is seldom mentioned in clinical observations. The development of immune suppression is considered to be the cause of these complications...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29880620/lipsch%C3%A3-tz-ulcer-and-group-a-streptococcal-tonsillitis
#15
Sara Limão, Ana Ventura, Gustavo Queirós, Florbela Cunha
Lipschütz ulcers (LU) are non-sexually related genital ulcers, rarely reported. We describe a healthy 11-year-old girl, who presented with fever and a painful vulvar ulcer associated with erythematous tonsillitis. Throat swab test for Group A Streptococcus (GAS) was positive. She was treated with amoxicillin. Further investigation was negative, including Herpes Simplex virus DNA from ulcer swab and serology for Epstein-Barr virus, cytomegalovirus and Mycoplasma pneumoniae Antistreptolysin O titre was high...
June 6, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29879547/the-influence-of-tap1-and-tap2-gene-polymorphisms-on-tap-function-and-its-inhibition-by-viral-immune-evasion-proteins
#16
P Praest, R D Luteijn, I G J Brak-Boer, J Lanfermeijer, H Hoelen, L Ijgosse, A I Costa, R D Gorham, R J Lebbink, E J H J Wiertz
Herpesviruses encode numerous immune evasion molecules that interfere with the immune system, particularly with certain stages in the MHC class I antigen presentation pathway. In this pathway, the transporter associated with antigen processing (TAP) is a frequent target of viral immune evasion strategies. This ER-resident transporter is composed of the proteins TAP1 and TAP2, and plays a crucial role in the loading of viral peptides onto MHC class I molecules. Several variants of TAP1 and TAP2 occur in the human population, some of which are linked to autoimmune disorders and susceptibility to infections...
June 4, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29875240/-in-vivo-knock-down-of-the-hsv-1-latency-associated-transcript-reduces-reactivation-from-latency
#17
Zachary L Watson, Shannan D Washington, Dane M Phelan, Alfred S Lewin, Sonal S Tuli, Gregory S Schultz, Donna M Neumann, David C Bloom
During Herpes Simplex Virus (HSV) latency, most viral genes are silenced with the exception of one region of the genome encoding the latency-associated transcript (LAT). This long non-coding RNA was originally described as having a role in enhancing HSV-1 reactivation. However, subsequent evidence showing that the LAT blocked apoptosis and promoted efficient establishment of latency suggested that its effects on reactivation were secondary to establishment. Here, we utilize an Adeno-associated Virus (AAV) vector to deliver a LAT-targeting hammerhead ribozyme to HSV-1-infected neurons of rabbits after the establishment of HSV-1 latency...
June 6, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29875197/comparison-of-herpes-simplex-virus-pcr-with-culture-for-virus-detection-in-multisource-surface-swab-specimens-from-neonates
#18
Samuel R Dominguez, Kristin Pretty, Randy Hengartner, Christine C Robinson
Background: The American Academy of Pediatrics currently recommends herpes simplex virus (HSV) culture over PCR for testing of swabs of the conjunctivae, mouth, nasopharynx, and rectum (surface swabs) in neonates. Objectives: To compare the performance and time to results of HSV PCR with HSV culture in surface swabs from neonates. Study Design: Banked multisource surface samples that had previously been cultured for HSV from infants less than or equal to 30 days old collected from January 2017 to December 2017 were identified and tested retrospectively by HSV PCR...
June 6, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29874387/hemidesmus-indicus-l-r-br-extract-inhibits-the-early-step-of-herpes-simplex-type-1-and-type-2-replication
#19
Francesca Bonvicini, Mariacaterina Lianza, Manuela Mandrone, Ferruccio Poli, Giovanna Angela Gentilomi, Fabiana Antognoni
Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) cause several clinically relevant syndromes in both adults and neonates. Despite the availability of efficient anti-HSV agents, the search for new therapeutic approaches is highly encouraged due to the increasing drug resistance of virus strains. Medicinal plants represent a source of potential bioactive compounds. In this context we evaluated the anti-herpetic activity of Hemidesmus indicus (L.) R. Br., a plant widely used in traditional Indian medicine. The hydroalcoholic extract prepared from roots was characterized by NMR and HPLC analysis and assayed in vitro by CPE reduction and virus infectivity assays to define its anti-viral effect...
June 6, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29873927/vertikale-%C3%A3-bertragung-des-herpes-simplex-virus-eine-aktualisierung
#20
REVIEW
Anil Kumar Bhatta, Uma Keyal, Yeqiang Liu, Emese Gellen
Infektionen mit den Herpes-simplex-Viren (HSV)-1 und -2 haben weltweit eine hohe Prävalenz. Eine HSV-Infektion während der Schwangerschaft kann eine neonatale Herpes-Infektion verursachen, die durch eine lebenslange Infektion mit Latenz- und Reaktivierungsperioden gekennzeichnet ist. Ein Säugling kann sich in utero (5 %), peripartal (85 %) oder postnatal (10 %) mit dem HS-Virus infizieren. Herpes neonatorum ist eine seltene aber bedeutsame Infektion, die mit schwerer Morbidität und Mortalität assoziiert sein kann, insbesondere bei Dissemination oder Beteiligung des zentralen Nervensystems...
June 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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