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https://www.readbyqxmd.com/read/28918148/mammalian-target-of-rapamycin-signaling-and-ubiquitin-proteasome-related-gene-expression-in-3-different-skeletal-muscles-of-colostrum-versus-formula-fed-calves
#1
H Sadri, J Steinhoff-Wagner, Harald M Hammon, R M Bruckmaier, S Görs, H Sauerwein
The rates of protein turnover are higher during the neonatal period than at any other time in postnatal life. The mammalian target of rapamycin (mTOR) and the ubiquitin-proteasome system are key pathways regulating cellular protein turnover. The objectives of this study were (1) to elucidate the effect of feeding colostrum versus milk-based formula on the mRNA abundance of key components of the mTOR pathway and of the ubiquitin-proteasome system in skeletal muscle of neonatal calves and (2) to compare different muscles...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28911840/compartmental-resection-of-peripheral-nerve-tumours-with-limb-preservation-in-16-dogs-1995-2011
#2
L van Stee, S Boston, E Teske, B Meij
Peripheral nerve tumours (PNTs) affecting the limbs may lead to chronic pain, lameness and/or monoparesis that is refractory to medical treatment. The most common radical therapy for PNTs has been surgical excision with limb amputation. However, compartmental resection with preservation of the limb has been performed by the authors with favourable clinical results and therefore this bi-institutional retrospective study was undertaken to assess limb function, survival and recurrence. Sixteen dogs that had been diagnosed with PNTs between 1995 and 2011 met the inclusion criteria for this study...
August 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28903439/lymph-node-status-in-different-molecular-subtype-of-breast-cancer-triple-negative-tumours-are-more-likely-lymph-node-negative
#3
Ning Liu, Zhigang Yang, Xiaozhen Liu, Yun Niu
BACKGROUND AND OBJECTIVES: To investigate the association between different molecular subtype (MST) and the axillary lymph nodal (ALN) status. MATERIALS AND METHODS: A total of 528 female patients with primary breast cancer were collected. Survival estimates were calculated using the Kaplan-Meier method, univariate and multivariate logistic regression models. RESULTS: Triple negative and Luminal A breast cancers were more frequently node-negative (N0) when compared to Luminal B and Her-2 positive cancers (77...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28901118/randomized-controlled-trial-of-maximal-strength-training-vs-standard-rehabilitation-following-total-knee-arthroplasty
#4
Vigdis S Husby, Olav A Foss, Otto S Husby, Siri B Winther
BACKGROUND: Total knee arthroplasty (TKA) alleviates pain, but muscle strength and function is reduced for a long period postoperatively. AIM: To investigate whether maximal strength training (MST) is more effective in improving muscle strength than standard rehabilitation (SR) after TKA. DESIGN: A randomized, controlled study. SETTING: Community physical therapy centers and University hospital research department. POPULATION: Forty-one adults <75 years with primary, unilateral osteoarthritis of the knee scheduled for TKA...
September 13, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28901017/efficiency-of-two-sample-tests-via-the-restricted-mean-survival-time-for-analyzing-event-time-observations
#5
Lu Tian, Haoda Fu, Stephen J Ruberg, Hajime Uno, Lee-Jen Wei
In comparing two treatments with the event time observations, the hazard ratio (HR) estimate is routinely used to quantify the treatment difference. However, this model dependent estimate may be difficult to interpret clinically especially when the proportional hazards (PH) assumption is violated. An alternative estimation procedure for treatment efficacy based on the restricted means survival time or t-year mean survival time (t-MST) has been discussed extensively in the statistical and clinical literature...
September 12, 2017: Biometrics
https://www.readbyqxmd.com/read/28894368/a-systematic-identification-of-species-specific-protein-succinylation-sites-using-joint-element-features-information
#6
Md Mehedi Hasan, Mst Shamima Khatun, Md Nurul Haque Mollah, Cao Yong, Dianjing Guo
Lysine succinylation, an important type of protein posttranslational modification, plays significant roles in many cellular processes. Accurate identification of succinylation sites can facilitate our understanding about the molecular mechanism and potential roles of lysine succinylation. However, even in well-studied systems, a majority of the succinylation sites remain undetected because the traditional experimental approaches to succinylation site identification are often costly, time-consuming, and laborious...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28885952/military-sexual-trauma-in-female-veterans-is-associated-with-chronic-pain-conditions
#7
Sara B Cichowski, Rebecca G Rogers, Elizabeth A Clark, Erin Murata, Allison Murata, Glen Murata
INTRODUCTION: Little is known about the impact of MST on chronic pain conditions among female Veterans. The primary objective of this study was to compare the prevalence of chronic pain conditions among U.S. female veterans with a history of military sexual trauma (MST) to those without a history of MST. We anticipated that female Veterans with a history of MST would have higher associations with chronic pain conditions than the female Veterans without a history of MST. MATERIALS AND METHODS: This was a large-scale, retrospective study using the Veterans' Health Administration Corporate Data Warehouse with institutional approval (15-H175)...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28880738/military-sexual-trauma-and-obesity-among-women-veterans
#8
Nivedita Pandey, Samir N Ashfaq, Edward W Dauterive, Andrea A MacCarthy, Laurel A Copeland
BACKGROUND/OBJECTIVE: Posttraumatic stress disorder (PTSD), the experience of military sexual trauma (MST) that may contribute to PTSD, and obesity are three issues that complicate care for our population of new veterans. Our aim was to analyze the association of MST and diagnosed PTSD with obesity among female veterans. MATERIALS AND METHODS: Women 20-103 years old using the Veterans Health Administration (VA) in fiscal year 2014 (October 2013-September 2014) with diagnosis and body-mass data were identified in administrative databases (213,985 of 404,183 women)...
September 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28876257/norwegian-study-on-microbial-source-tracking-for-water-quality-control-and-pollution-removal-in-constructed-wetland-treating-catchment-run-off
#9
Lisa Paruch, Adam M Paruch, Anne-Grete Buseth Blankenberg, Ketil Haarstad, Trond Mæhlum
This study describes the first Norwegian microbial source tracking (MST) approach for water quality control and pollution removal from catchment run-off in a nature-based treatment system (NBTS) with a constructed wetland. The applied MST tools combined microbial analyses and molecular tests to detect and define the source(s) and dominant origin(s) of faecal water contamination. Faecal indicator bacteria Escherichia coli and host-specific Bacteroidales 16 s rRNA gene markers have been employed. The study revealed that the newly developed contribution profiling of faecal origin derived from the Bacteroidales DNA could quantitatively distinguish between human and non-human pollution origins...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28867925/adolescent-physiological-and-behavioral-patterns-of-emotion-dysregulation-predict-multisystemic-therapy-response
#10
D Anne Winiarski, Julia C Schechter, Patricia A Brennan, Sharon L Foster, Phillippe B Cunningham, Elizabeth A Whitmore
This study examined whether physiological and behavioral indicators of emotion dysregulation assessed over the course of Multisystemic Therapy (MST) were related to treatment response. Participants were 180 ethnically diverse adolescents (n=120 males), ranging in age from 12 to 17 years. Treatment response was assessed through therapist report and official arrest records. Changes in cortisol reactivity and changes in scores on a behavioral dysregulation subscale of the Child Behavior Checklist were used as indicators of emotion dysregulation...
September 2017: Journal of Emotional and Behavioral Disorders
https://www.readbyqxmd.com/read/28858718/impact-of-salt-induced-toxicity-on-growth-and-yield-potential-of-local-wheat-cultivars-oxidative-stress-and-ion-toxicity-are-among-the-major-determinants-of-salt-tolerant-capacity
#11
Md Nurealam Siddiqui, Mohammad Golam Mostofa, Mst Mahmuda Akter, Ashish Kumar Srivastava, Md Abu Sayed, M Shamim Hasan, Lam-Son Phan Tran
High salinity is a major constraint for wheat productivity in many countries, including Bangladesh. Here, we examined the effects of salt-induced toxicity on growth and production of 10 local wheat cultivars by analyzing physiological, biochemical and agronomical responses to identify the salt-tolerant attributes among the contrasting genotypes. Results of cluster analyses based on salt tolerance indices of plant growth-related and yield-contributing parameters, ionic balance (Na(+), K(+) and Na(+)/K(+) ratio), and stress indicators (SPAD values and proline) revealed Gourab and Shatabdi as salt-sensitive, BARI Gom 27 and 28 as salt-tolerant and the other six examined varieties as moderately salt-tolerant cultivars...
August 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28833175/mst-1-deficiency-promotes-post-traumatic-spinal-motor-neuron-survival-via-enhancement-of-autophagy-flux
#12
Mengting Zhang, Wufan Tao, Zengqiang Yuan, Yaobo Liu
The mammalian Ste20-like kinase 1 (Mst-1) is a serine-threonine kinase and a component of the Hippo tumor suppressor pathway, which reacts to pathologically relevant stress and regulates cell death. However, little is known about its role in spinal cord injury (SCI). Here, we found that p-Mst-1, the activated form of Mst-1, was induced in the post-traumatic spinal motor neurons. In vivo evidence demonstrated that Mst-1 deficiency promoted post-traumatic spinal motor neuron survival, BMS scores, and synapse survival...
August 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28826770/genotype-distribution-of-chinese-mycoplasma-bovis-isolates-and-their-evolutionary-relationship-to-strains-from-other-countries
#13
Harish Menghwar, Chenfei He, Hui Zhang, Gang Zhao, Xifang Zhu, Farhan Anwar Khan, Muhammad Faisal, Muhammad Asif Rasheed, Muhammad Zubair, Atta Muhammad Memon, Anne Ridley, Ian D Robertson, Yingyu Chen, Aizhen Guo
This study was undertaken to determine the genotypic distribution of Chinese M. bovis strains and their similarity to isolates from other countries. Two multilocus sequence typing (MLST) schemes (MLST-1 and MLST-2) and pulsed field gel electrophoresis (PFGE) were used to compare 44 Chinese strains and the M. bovis type strain PG45. The results showed a high genetic homogeneity of Chinese isolates; 43 of 44 (97.7%) Chinese isolates were identified as ST-10 and as ST-34 by MLST-1, while for MLST-2 42 of 44 (95...
August 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28817592/using-k-dependence-causal-forest-to-mine-the-most-significant-dependency-relationships-among-clinical-variables-for-thyroid-disease-diagnosis
#14
LiMin Wang, FangYuan Cao, ShuangCheng Wang, MingHui Sun, LiYan Dong
Numerous data mining models have been proposed to construct computer-aided medical expert systems. Bayesian network classifiers (BNCs) are more distinct and understandable than other models. To graphically describe the dependency relationships among clinical variables for thyroid disease diagnosis and ensure the rationality of the diagnosis results, the proposed k-dependence causal forest (KCF) model generates a series of submodels in the framework of maximum spanning tree (MST) and demonstrates stronger dependence representation...
2017: PloS One
https://www.readbyqxmd.com/read/28810979/women-veterans-a-population-at-risk-for-fibromyalgia-the-associations-between-fibromyalgia-symptoms-and-quality-of-life
#15
Rita F D'Aoust, Alicia Gill Rossiter, Amanda Elliott, Ming Ji, Cecile Lengacher, Maureen Groer
BACKGROUND: The Institute of Federal Health Care recently published an executive summary from a round table discussion indicating that active duty and retired female military personnel are at high risk for adverse health outcomes unique to military service including complications related to post-traumatic stress disorder (PTSD), unreported sexual trauma, and musculoskeletal problems. In 2008, the Institute of Medicine began to review, evaluate, and summarize the literature on health outcomes in Gulf War-deployed and found sufficient evidence of a causal relationship with PTSD and suggestive evidence of an association with fibromyalgia (FM)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28806368/increased-health-care-utilization-and-costs-among-veterans-with-a-positive-screen-for-military-sexual-trauma
#16
Emily Brignone, Adi V Gundlapalli, Rebecca K Blais, Rachel Kimerling, Tyson S Barrett, Richard E Nelson, Marjorie E Carter, Matthew H Samore, Jamison D Fargo
BACKGROUND: The effects of sexual trauma on long-term health care utilization and costs are not well understood due to infrequent documentation of sexual trauma history in health care systems. The Veteran's Health Administration provides a unique opportunity to address this constraint as sexual trauma is actively screened for as part of routine care. METHODS: We used a retrospective cohort design to analyze Veteran's Health Administration mental health and medical service utilization and costs as a function of a positive screen for exposure to military sexual trauma (MST) among Veterans of recent conflicts in Iraq and Afghanistan...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28804545/hydrogen-sulfide-prevents-diaphragm-weakness-in-cecal-ligation-puncture-induced-sepsis-by-preservation-of-mitochondrial-function
#17
Hai-Xia Zhang, Jun-Ming Du, Zhong-Nuo Ding, Xiao-Yan Zhu, Lai Jiang, Yu-Jian Liu
Mitochondrial dysfunction plays an important role in the pathogenesis of diaphragm weakness during sepsis. Recently, hydrogen sulfide (H2S), a gaseous transmitter endogenously generated by cystathionine-β-synthase (CBS), cystathionine-γ-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3-MST), is found to improve mitochondrial function. The present study aimed to examine whether H2S synthases are expressed in the diaphragm, and investigated the effect of H2S donor in sepsis-induced diaphragm weakness and its relationship with mitochondrial function...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28801594/deficiency-in-catechol-o-methyltransferase-is-linked-to-a-disruption-of-glucose-homeostasis-in-mice
#18
Megumi Kanasaki, Swayam Prakash Srivastava, Fan Yang, Ling Xu, Sumiyo Kudoh, Munehiro Kitada, Norikazu Ueki, Hyoh Kim, Jinpeng Li, Satoru Takeda, Keizo Kanasaki, Daisuke Koya
2-methoxyestradiol (2-ME), an estrogen metabolite generated via catechol-o-methyltransferase (COMT), is multifunctional methoxy-catechol. Here, we report that COMT deficiency leads to glucose intolerance and 2-ME rescues COMT-deficient-associated metabolic defects. Liver COMT protein was suppressed in high fat diet (HFD)-fed or in pregnant mice. COMT suppression, by Ro41-0960 or siRNA, in HFD fed mice or in pregnant mice exacerbated glucose intolerance; 2-ME intervention ameliorated these defects. 2-ME effects on glucose tolerance were associated with AMPK phosphorylation in the liver and in islet cells...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795387/gefitinib-plus-fuzheng-kang-ai-formula-in-patients-with-advanced-non-small-cell-lung-cancer-with-epidermal-growth-factor-receptor-mutation-a-randomized-controlled-trial
#19
Xiao-Bing Yang, Xiao-Shu Chai, Wan-Yin Wu, Shun-Qin Long, Hong Deng, Zong-Qi Pan, Wen-Feng He, Yu-Shu Zhou, Gui-Ya Liao, Shu-Jing Xiao
OBJECTIVE: To evaluate the effect of Fuzheng Kang'ai Formula (, FZKA) plus gefitinib in patients with advanced non-small cell lung cancer with epidermal growth factor receptor (EGFR) mutations. METHODS: A randomized controlled trial was conducted from 2009 to 2012 in South China. Seventy chemotherapynaive patients diagnosed with stage IIIB/IV non-small cell lung cancer with EGFR mutations were randomly assigned to GF group [gefifitinib (250 mg/day orally) plus FZKA (250 mL, twice per day, orally); 35 cases] or G group (gefifitinib 250 mg/day orally; 35 cases) according to the random number table and received treatment until progression of the disease, or development of unacceptable toxicities...
August 9, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28783792/comparison-of-the-performance-of-different-microbial-source-tracking-markers-among-european-and-north-african-regions
#20
Mariem Yahya, Anicet R Blanch, Wim G Meijer, Katerina Antoniou, Fatma Hmaied, Elisenda Ballesté
Microbial source tracking (MST) has been extensively used to detect the sources of fecal pollution in water. The inclusion of MST in water management strategies improves the ecological status of the ecosystem and human and animal health under interdisciplinary analysis in all aspects of health care for humans, animals, and the environment (One Health approach). In this study, the performance of MST markers targeting host-specific Bacteroidales (HF183 and Rum-2-Bac) and species (HMBif and CWBif) were evaluated in raw sewage collected from human, ruminant, swine, and poultry sources in Tunisia, Cyprus, Ireland, and Spain...
July 2017: Journal of Environmental Quality
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