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https://www.readbyqxmd.com/read/28538993/fefsem-neuronal-response-during-combined-volitional-and-reflexive-pursuit
#1
Leah Bakst, Jérome Fleuriet, Michael J Mustari
Although much is known about volitional and reflexive smooth eye movements individually, much less is known about how they are coordinated. It is hypothesized that separate cortico-ponto-cerebellar loops subserve these different types of smooth eye movements. Specifically, the MT-MST-DLPN pathway is thought to be critical for ocular following eye movements, whereas the FEF-NRTP pathway is understood to be vital for volitional smooth pursuit. However, the role that these loops play in combined volitional and reflexive behavior is unknown...
May 1, 2017: Journal of Vision
https://www.readbyqxmd.com/read/28520570/long-term-exposure-to-mst-312-leads-to-telomerase-reverse-transcriptase-overexpression-in-mcf-7-breast-cancer-cells
#2
Karollyne S Morais, Ana Flávia R Guimarãesb, Doralina A R Ramos, Fábio P Silva, Diêgo M de Oliveira
Telomerase is an enzyme responsible for telomere maintenance in almost all human cancer cells, but generally not expressed in somatic ones. Therefore, antitelomerase therapy is a potentially revolutionary therapeutic strategy, and the antitumor activity of telomerase inhibitors (TI) has been studied extensively recently, mainly for breast cancer. However, the effects expected from treatment with TI will appear only after many cell divisions, but the effects of this long-term approach are unknown. In this work, the consequences of 3120 h exposure of human breast cancer cells to TI MST-312 were investigated...
May 17, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28511679/evaluation-of-anti-inflammatory-and-gastric-anti-ulcer-activity-of-phyllanthus-niruri-l-euphorbiaceae-leaves-in-experimental-rats
#3
Ronia Mostofa, Shanta Ahmed, Mst Marium Begum, Md Sohanur Rahman, Taslima Begum, Siraj Uddin Ahmed, Riazul Haque Tuhin, Munny Das, Amir Hossain, Manju Sharma, Rayhana Begum
BACKGROUND: The medicinal plants signify a massive basin of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Phyllanthus niruri L. (Euphorbiaceae) is generally used in traditional medicine to treat ulcer and inflammation. In this project we investigated the methanolic extract of leaves of Phyllanthus niruri for anti-inflammatory and anti-ulcer activity. METHODS: The anti-inflammatory activity of methanol extract of Phyllanthus niruri leaves was evaluated at the doses of 100, 200 and 400 mg/kg, p...
May 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28511110/determination-of-regional-relationships-among-salmonella-spp-isolated-from-retail-pork-circulating-in-the-chiang-mai-municipality-area-using-a-wgs-data-approach
#4
Prapas Patchanee, Thanaporn Eiamsam-Ang, Juntakarn Vanaseang, Phacharaporn Boonkhot, Pakpoom Tadee
Salmonella is recognized as a significant zoonotic foodborne pathogen, and pork products are involved in one-fifth of infections. Whole genome sequencing data of Salmonella isolated from retail's pork circulating in the Chiang Mai Municipality area between April 2013 and September 2014, were used to focus on genetic diversity and proven in pig-human transmission based on Multilocus Sequence Typing (MLST). Additionally, WGS data were used to investigate virulence genes, to assess the hazard or pathogenic potential transferred into the food production chain...
May 10, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28508494/high-dose-prednisolone-after-intravenous-methylprednisolone-improves-prognosis-of-acute-exacerbation-in-idiopathic-interstitial-pneumonias
#5
Toru Arai, Kazunobu Tachibana, Chikatoshi Sugimoto, Yasushi Inoue, Sayoko Tokura, Tomohisa Okuma, Masanori Akira, Masanori Kitaichi, Seiji Hayashi, Yoshikazu Inoue
BACKGROUND AND OBJECTIVE: Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) (AE-IPF) is a poor prognostic disorder. AE is also reported to occur in other idiopathic interstitial pneumonias (IIPs). There are limited data available regarding the effectiveness of treatment for AE-IIPs. The objective of this study was to clarify the prognostic impact of the initial dose of prednisolone (PSL) for treating AE-IIPs. METHODS: Eighty-five patients with AE-IIPs, diagnosed according to the criteria of the Japanese Respiratory Society, were enrolled in this study (IPF/non-IPF: 63/22 patients) from 2004 to 2013...
May 15, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28506880/advanced-correlation-grid-analysis-and-visualisation-of-functional-connectivity-among-multiple-spike-trains
#6
Mohammad Shahed Masud, Roman Borisyuk, Liz Stuart
BACKGROUND: This study analyses multiple spike trains (MST) data, defines its functional connectivity and subsequently visualises an accurate diagram of connections. This is a challenging problem. For example, it is difficult to distinguish the common input and the direct functional connection of two spike trains. NEW METHOD: The new method presented in this paper is based on the traditional pairwise cross-correlation function (CCF) and a new combination of statistical techniques...
May 12, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28506139/effects-of-aging-and-depression-on-mnemonic-discrimination-ability
#7
D A Camfield, R Fontana, K A Wesnes, J Mills, R J Croft
Ageing and depression have been found to be associated with poorer performance in mnemonic discrimination. In the current study, a two-response format mnemonic similarity test, Cognitive Drug Research MST, was used to compare these effects. Seventy-six participants were tested; with 52 participants in the young group, aged 18-35 years, and 24 participants in the elderly group, aged 55 years or older. Twenty-two young participants and 10 elderly participants met DSM-IV criteria for MDD or dysthymia. Age-related deficits were found for lure identification and speed of response...
May 16, 2017: Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
https://www.readbyqxmd.com/read/28491028/resting-state-functional-connectivity-and-network-analysis-of-cerebellum-with-respect-to-crystallized-iq-and-gender
#8
Vasileios C Pezoulas, Michalis Zervakis, Sifis Michelogiannis, Manousos A Klados
During the last years, it has been established that the prefrontal and posterior parietal brain lobes, which are mostly related to intelligence, have many connections to cerebellum. However, there is a limited research investigating cerebellum's relationship with cognitive processes. In this study, the network of cerebellum was analyzed in order to investigate its overall organization in individuals with low and high crystallized Intelligence Quotient (IQ). Functional magnetic resonance imaging (fMRI) data were selected from 136 subjects in resting-state from the Human Connectome Project (HCP) database and were further separated into two IQ groups composed of 69 low-IQ and 67 high-IQ subjects...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28488917/contrasting-gender-and-combat-versus-military-sexual-traumas-psychiatric-symptom-severity-and-morbidities-in-treatment-seeking-veterans
#9
Minden B Sexton, Greer A Raggio, Lauren B McSweeney, Caitlin C Authier, Sheila A M Rauch
BACKGROUND: Military sexual trauma (MST) and military combat trauma (MCT) are significant risk factors for posttraumatic stress disorder (PTSD). However, no studies have directly contrasted the clinical profiles of Veterans between military-related traumas. Moreover, a notable gender difference in the likelihood of trauma exposure limits our ability to disentangle gender and trauma type. MATERIALS AND METHODS: To address these gaps, we aimed at (1) contrasting psychiatric complaints in Veterans with MST versus MCT exposure and (2) investigating gender differences in Veterans with MST histories...
May 10, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28488308/large-scale-network-organization-of-eeg-functional-connectivity-in-newborn-infants
#10
Brigitta Tóth, Gábor Urbán, Gábor P Háden, Molnár Márk, Miklós Török, Cornelis Jan Stam, István Winkler
The organization of functional brain networks changes across human lifespan. The present study analyzed functional brain networks in healthy full-term infants (N = 139) within 1-6 days from birth by measuring neural synchrony in EEG recordings during quiet sleep. Large-scale phase synchronization was measured in six frequency bands with the Phase Lag Index. Macroscopic network organization characteristics were quantified by constructing unweighted minimum spanning tree graphs. The cortical networks in early infancy were found to be significantly more hierarchical and had a more cost-efficient organization compared with MST of random control networks, more so in the theta and alpha than in other frequency bands...
May 10, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28487647/meg-beamformer-based-reconstructions-of-functional-networks-in-mild-cognitive-impairment
#11
Maria E López, Marjolein M A Engels, Elisabeth C W van Straaten, Ricardo Bajo, María L Delgado, Philip Scheltens, Arjan Hillebrand, Cornelis J Stam, Fernando Maestú
Subjects with mild cognitive impairment (MCI) have an increased risk of developing Alzheimer's disease (AD), and their functional brain networks are presumably already altered. To test this hypothesis, we compared magnetoencephalography (MEG) eyes-closed resting-state recordings from 29 MCI subjects and 29 healthy elderly subjects in the present exploratory study. Functional connectivity in different frequency bands was assessed with the phase lag index (PLI) in source space. Normalized weighted clustering coefficient (normalized Cw) and path length (normalized Lw), as well as network measures derived from the minimum spanning tree [MST; i...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28486527/prognostic-impact-of-egfr-mutation-in-non-small-cell-lung-cancer-patients-with-family-history-of-lung-cancer
#12
Jung Soo Kim, Min Seong Cho, Jong Hyeon Nam, Hyun-Jung Kim, Kyeng-Won Choi, Jeong-Seon Ryu
BACKGROUND: A family history can be a valuable tool in the era of precision medicine. Although a few studies have described an association of family history of lung cancer with EGFR activating mutation, their impact on survival of lung cancer patients is unclear. METHODS: The study included consecutive 829 non-small-cell lung cancer patients who received analysis of EGFR mutation in a prospective lung cancer cohort. Family history of lung cancer was obtained by face-to-face interviews at the time of diagnosis...
2017: PloS One
https://www.readbyqxmd.com/read/28485687/therapeutic-response-to-cognitive-processing-therapy-in-white-and-black-female-veterans-with-military-sexual-trauma-related-ptsd
#13
Ryan P Holliday, Nicholas D Holder, Meredith L C Williamson, Alina Surís
Cognitive Processing Therapy (CPT) is an evidence-based treatment (EBT) for posttraumatic stress disorder (PTSD) which has been validated for female veterans with military-related PTSD. Existing trials have enrolled predominantly White veterans with some studies documenting higher rates of early termination from EBTs among Black females when compared to White females. Data from a previously published randomized clinical trial were used to evaluate the effectiveness of CPT for Black female veterans with military sexual trauma (MST)-related PTSD...
May 9, 2017: Cognitive Behaviour Therapy
https://www.readbyqxmd.com/read/28481637/hydrogen-sulfide-a-novel-player-in-airway-development-pathophysiology-of-respiratory-diseases-and-antiviral-defenses
#14
Nikolay Bazhanov, Maria Ansar, Teodora Ivanciuc, Roberto P Garofalo, Antonella Casola
Hydrogen sulfide (H2S) is a biologically relevant signaling molecule in mammals. Together with the volatile substances nitric oxide (NO) and carbon monoxide (CO), H2S is defined as a gasotransmitter, playing a physiological role in a variety of functions such as synaptic transmission, vascular tone, angiogenesis, inflammation and cellular signaling. The generation of H2S is catalyzed by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE) and 3 mercaptopyruvate sulfurtransferase (3-MST). The expression of CBS and CSE is tissue-specific with CBS being expressed predominantly in the brain and CSE in peripheral tissues, including lungs...
May 8, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28476323/the-malnutrition-screening-tool-in-geriatric-rehabilitation-a-comparison-of-validity-when-completed-by-health-professionals-with-and-without-malnutrition-screening-training-has-implications-for-practice
#15
Skye Marshall, Adrienne Young, Elizabeth Isenring
BACKGROUND: The validity of the Malnutrition Screening Tool (MST) in geriatric rehabilitation has been evaluated in a research environment but not in professional practice. OBJECTIVE: In older adults admitted to rehabilitation, this study was undertaken to compare the MST scoring agreement (inter-rater reliability) between health professionals with and without malnutrition risk and screening training; to evaluate the concurrent validity of the MST completed by the trained and untrained health professionals compared to the International Classification of Diseases, Tenth Revision, Australian Modification using different MST score cutoffs; and to determine whether patient characteristics were associated with MST scoring accuracy when completed by health professionals without malnutrition risk and screening training...
May 2, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28472867/effects-of-whey-and-soy-protein-addition-on-bread-rheological-property-of-wheat-flour
#16
Jianmin Zhou, Junfei Liu, Xiaozhi Tang
The development of wheat-based foods that are enriched with proteins is increasingly popular due to consumer demand regarding food nutritional content and quality. This study was performed to compare the effect of whey and soy protein on the rheological properties of wheat dough and bread-making quality in a relatively wide range of protein addition (0-30%). We found that the incorporation of whey protein (WP) decreased dough stability time (MST), minimum torque (MMT), G' and G", but increased dough peak torque (MPT), stickiness, G' and G" in temperature sweep...
May 4, 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28468890/protein-intakes-are-associated-with-reduced-length-of-stay-a-comparison-between-enhanced-recovery-after-surgery-eras-and-conventional-care-after-elective-colorectal-surgery
#17
Sophia E Yeung, Leslee Hilkewich, Chelsia Gillis, John A Heine, Tanis R Fenton
Background: Protein can modulate the surgical stress response and postoperative catabolism. Enhanced Recovery After Surgery (ERAS) protocols are evidence-based care bundles that reduce morbidity.Objective: In this study, we compared protein adequacy as well as energy intakes, gut function, clinical outcomes, and how well nutritional variables predict length of hospital stay (LOS) in patients receiving ERAS protocols and conventional care.Design: We conducted a prospective cohort study in adult elective colorectal resection patients after conventional (n = 46) and ERAS (n = 69) care...
May 3, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28468008/effect-of-maxing-shigan-tang-on-h1n1-influenza-a-virus-associated-acute-lung-injury-in-mice
#18
Yanchun Zhong, Jie Zhou, Ning Liang, Bihao Liu, Ruirui Lu, Yu He, Chunlin Liang, Junbiao Wu, Yuan Zhou, Miaomiao Hu, Jiuyao Zhou
OBJECTIVE: This study is aimed at examining the effects of Maxing Shigan Tang (MST) treatment on H1N1-associated acute lung injury (ALI) and exploring the possible mechanism. MATERIAL AND METHODS: Mice were randomly divided into a control group, model group, peroxisomal proliferator activator receptor γ (PPARγ) inhibition group (PPARγ-), PPARγ activation group (PPARγ+), and MST group. Influenza A (H1N1) virus of the Fort Monmouth 1 (FM1) strain was used to induce an ALI mice model...
May 4, 2017: Intervirology
https://www.readbyqxmd.com/read/28460138/the-relative-impact-of-sleep-and-circadian-drive-on-motor-skill-acquisition-and-memory-consolidation
#19
Matthew A Tucker, Christopher J Morris, Alexandra Morgan, Jessica Yang, Samantha Myers, Joanna Garcia Pierce, Robert Stickgold, Frank A J L Scheer
Study Objectives: Sleep during the biological night facilitates memory consolidation. Here we determined the impact of sleep and wake on motor skill learning (acquisition) and subsequent off-line skill improvement (memory consolidation), independent of circadian phase, and compared this to the impact of the endogenous circadian system, independent of whether sleep occurred during the biological night or day. Methods: Participants completed two 8-day sleep laboratory visits, adhering on one visit to a circadian aligned ("normal") sleep schedule for the full duration of the protocol, and on the other to a circadian misaligned (12-hour inverted) schedule, with alignment during the first 3 days, a 12-hour 'slam shift' on Day 4, followed by circadian misalignment during the last 4 days of the protocol...
April 1, 2017: Sleep
https://www.readbyqxmd.com/read/28458504/multisystemic-therapy-for-emerging-adults-with-serious-mental-illness-and-justice-involvement
#20
Ashli J Sheidow, Michael R McCart, Maryann Davis
Most serious mental illnesses (SMI) have onset by emerging adulthood and SMI can impair adolescents' transitions into healthy, productive adults. Emerging adults (EAs) with SMI are at high risk for justice involvement, and rates of recidivism are greater for offenders with SMI than without. These EAs are frequently multi-system involved (e.g., aging out of foster care; both juvenile and adult arrests; prison reentry). Few interventions, however, have focused specifically on EAs, and no interventions have focused on reducing recidivism in EAs with or without SMI...
August 2016: Cognitive and Behavioral Practice
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