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https://www.readbyqxmd.com/read/28230929/investigation-of-p16-status-chemotherapy-regimen-and-other-nutrition-markers-for-predicting-gastrostomy-in-patients-with-head-and-neck-cancer
#1
Teresa E Brown, Kym Wittholz, Mandy Way, Merrilyn D Banks, Brett G M Hughes, Charles Y Lin, Lizbeth M Kenny, Judith D Bauer
BACKGROUND: The purpose of this study was to determine if p16 status, chemotherapy regimen, or other nutrition markers could improve protocol accuracy in predicting proactive gastrostomy in patients with head and neck cancer. METHODS: Patients who received curative treatment from July 2010 to June 2011 were included (n = 269). Associations among dependent variables (age, sex, tumor site, staging, treatment, p16 status, albumin, and Malnutrition Screening Tool [MST] score), the protocol risk rating, and requirement for proactive gastrostomy were examined...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28230018/the-significance-of-transarterial-chemoembolization-combined-with-systemic-chemotherapy-for-patients-with-kras-wild-type-unresectable-metachronous-colorectal-carcinoma-with-liver-metastases
#2
Qiming Yu, Lusha Zhang, Sunfu Fan, Ling Huang, Xinbao Wang, Cai Xindun
PURPOSE: The purpose of this study was to assess the survival benefits of transarterial chemoembolization (TACE) combined with systemic chemotherapy as the first-line treatment for metachronous unresectable colorectal carcinoma with liver metastases (CLMs) and to identify prognostic determinants. PATIENTS AND METHODS: One hundred and fifty-four patients with KRAS wild-type metachronous unresectable CLMs were retrospectively collected from January 2006 to December 2014...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28227408/structural-brain-network-analysis-in-schizophrenia-using-minimum-spanning-tree
#3
Ali Anjomshoa, Mahsa Dolatshahi, Fatemeh Amirkhani, Farzaneh Rahmani, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Ali Anjomshoa, Mahsa Dolatshahi, Fatemeh Amirkhani, Farzaneh Rahmani, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Mehdi M Mirbagheri, Mahsa Dolatshahi, Ali Anjomshoa, Farzaneh Rahmani, Fatemeh Amirkhani, Mohammad Hadi Aarabi
Schizophrenia is a mental disorder in which functional and structural brain networks are disrupted. Classical network analysis has been used by many researchers to quantify brain networks and to study the network changes in schizophrenia, but unfortunately metrics used in this classical method highly depend on the networks' density and weight; the comparisons made by this method are biased. The minimum spanning tree (MST) is an alternative method to solve this problem, but its usefulness in studying the schizophrenic brain network has not been examined yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226718/automated-tracing-of-microglia-using-multilevel-thresholding-and-minimum-spanning-trees
#4
Mahmoud Abdolhoseini, Frederick Walker, Sarah Johnson, Mahmoud Abdolhoseini, Frederick Walker, Sarah Johnson, Sarah Johnson, Mahmoud Abdolhoseini, Frederick Walker
Microglia are immune cells of the central nervous system. Good knowledge about their morphology leads us to a better understanding of their functionality. In this article we propose an automated method to trace microglia in microscopy images. Our approach is powered by two main algorithms: multilevel thresholding (MT) and minimum spanning tree (MST). MT quantizes intensities of image pixels to several levels, then we sample each level with different rates to produce seed points. Each seed point belongs to a level and has a specific value, therefore they can be prioritized...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222892/fdg-uptake-in-normal-tissues-assessed-by-pet-during-treatment-has-prognostic-value-for-treatment-results-in-head-and-neck-squamous-cell-carcinomas-undergoing-radiochemotherapy
#5
Sebastian Zschaeck, Steffen Löck, Stefan Leger, Robert Haase, Anna Bandurska-Luque, Steffen Appold, Jörg Kotzerke, Daniel Zips, Christian Richter, Volker Gudziol, Andreas Schreiber, Klaus Zöphel, Michael Baumann, Mechthild Krause
BACKGROUND AND PURPOSE: Pronounced early side effects have been suggested to be a positive prognostic factor in patients undergoing chemo-radio-therapy (CRT) for head and neck squamous cell carcinomas (HNSCC). We assessed the utility of positron emission tomography (PET) during treatment to analyze the correlation of 18F-fluorodeoxyglucose (FDG) uptake in off target structures within the irradiated volume with outcome. MATERIAL AND METHODS: Two independent cohorts of patients with locally advanced HNSCC, both treated within prospective clinical imaging trials with curatively intended CRT were retrospectively analyzed...
February 17, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28222686/ipsiversive-ictal-eye-deviation-in-inferioposterior-temporal-lobe-epilepsy-two-seeg-cases-report
#6
Wei Zhang, Xingzhou Liu, Lijun Zuo, Qiang Guo, Qi Chen, Yongjun Wang
BACKGROUND: Versive seizure characterized by conjugate eye movement during epileptic seizure has been considered commonly as one of the most valuable semiological signs for epilepsy localization, especially for frontal lobe epilepsy. However, thelateralizing and localizing significance of ictaleye deviation has been questioned by clinical observation of a series of focal epilepsy studies, including frontal, central, temporal, parietal and occipital epilepsy. CASE PRESENTATION: Two epileptic cases characterized by ipsiversive eye deviation as initial clinical sign during the habitual epileptic seizures are presented in this paper...
February 21, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28222374/diuron-causes-sinking-retardation-and-physiochemical-alteration-in-marine-diatoms-thalassiosira-pseudonana-and-skeletonema-marinoi-dohrnii-complex
#7
Mst Ruhina Margia Khanam, Yohei Shimasaki, Md Zahangir Hosain, Koki Mukai, Michito Tsuyama, Xuchun Qiu, Rumana Tasmin, Hiroshi Goto, Yuji Oshima
The present research investigated the effect of diuron on sinking rate and the physiochemical changes in two marine diatoms, Thalassiosira pseudonana (single-celled species) and Skeletonema marinoi-dohrnii complex (chain-forming species). The results revealed that the sinking rate of both diatoms exposed to diuron at a level of 50% effective concentration for growth (EC50) decreased significantly compared with the control. Photosynthetic performance (Fv/Fm and PIABS) of both diatoms also decreased significantly with diuron exposure...
February 10, 2017: Chemosphere
https://www.readbyqxmd.com/read/28220417/steady-state-and-kinetics-based-affinity-determination-in-effector-effector-target-interactions
#8
André Reinhard, Thorsten Nürnberger
Dissecting the functional basis of pathogenicity and resistance in the context of plant innate immunity benefits greatly from detailed knowledge about biomolecular interactions, as both resistance and virulence depend on specific interactions between pathogen and host biomolecules. While in vivo systems provide biological context to host-pathogen interactions, these experiments typically cannot provide quantitative biochemical characterization of biomolecular interactions. However, in many cases, the biological function does not only depend on whether an interaction occurs at all, but rather on the "intensity" of the interaction, as quantified by affinity...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28219358/mst-4-and-traf-6-expression-in-the-peripheral-blood-mononuclear-cells-of-patients-with-graves-disease-and-its-significance
#9
Ai Guo, Yan Tan, Chun Liu, Xiaoya Zheng
BACKGROUND: MST-4 and TRAF-6 are involved in the regulation of inflammatory and immune responses. However, whether they participate in the pathogenesis of Graves' disease (GD) has not yet been reported. Therefore, the purpose of this study was to investigate the expression of MST-4 and TRAF-6 in the peripheral blood of patients with GD to understand their role in the pathogenesis of GD. METHODS: Thirty newly diagnosed GD patients, 24 GD patients in remission (eGD) and 30 normal controls (NC) were recruited...
February 20, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28219206/-correlations-between-genetic-variations-of-glutathione-synthetase-gene-and-the-response-to-platinum-based-chemotherapy-and-prognosis-of-small-cell-lung-cancer-patients
#10
T Feng, H M Li, P Yuan, D K Yu, F Ma, W W Tan, Z L Du, J Yang, Y Huang, D X Lin, B H Xu, W Tan
Objective: To explore the associations between genetic variations of glutathione synthetase gene (GSS) and response to platinum-based chemotherapy of small cell lung cancer(SCLC), and to analyze the influencing factors on survival. Methods: Four haplotype-tagging single nucleotide polymorphisms (htSNPs) of GSS were genotyped by Sequenom MassARRAY methods in 903 SCLC patients who received platinum-based chemotherapy, and had different response and survival time. The associations between genotypes and platinum-based chemotherapy response were measured by odds ratios (OR) and 95% confidence intervals (CI), adjusted for sex, age, smoking, KPS, staging and chemotherapy regiments, by unconditional logistic regression model...
February 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28212299/exogenous-and-endogenous-hydrogen-sulfide-protects-gastric-mucosa-against-the-formation-and-time-dependent-development-of-ischemia-reperfusion-induced-acute-lesions-progressing-into-deeper-ulcerations
#11
Marcin Magierowski, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Zbigniew Sliwowski, Robert Pajdo, Grzegorz Ginter, Slawomir Kwiecien, Tomasz Brzozowski
Hydrogen sulfide (H₂S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST). The mechanism(s) involved in H₂S-gastroprotection against ischemia/reperfusion (I/R) lesions and their time-dependent progression into deeper gastric ulcerations have been little studied. We determined the effect of l-cysteine, H₂S-releasing NaHS or slow H₂S releasing compound GYY4137 on gastric blood flow (GBF) and gastric lesions induced by 30 min of I followed by 3, 6, 24 and 48 h of R...
February 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28206891/survival-of-adhesive-restorations-for-primary-molars-a-systematic-review-and-metaanalysis-of-clinical-trials
#12
Ana Paula Santos, Ianny K D Moreira, Ana Carolina Scarpelli, Isabela A Pordeus, Saul M Paiva, Carolina C Martins
PURPOSE: The purpose of this study was to assess the scientific evidence regarding the survival and clinical performance of adhesive materials for primary molars, comparing composite resin (CR), conventional glass ionomer cement (GIC), resin-modified glass ionomer (RMGIC), silver-reinforced glass ionomer cement, and compomer. METHODS: Six databases were searched without restrictions regarding language or year of publication. Meta-analysis was conducted; risk ratios (RRs) and 95 percent confidence intervals (95% CI) were calculated...
October 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28203281/minimum-absolute-lymphocyte-counts-during-radiation-are-associated-with-a-worse-prognosis-in-patients-with-unresectable-hepatocellular-carcinoma
#13
Qianqian Zhao, Xiaoqing Xu, Jinbo Yue, Kunli Zhu, Rui Feng, Shumei Jiang, Zhonghua Qi, Renben Wang
BACKGROUND: Peripheral blood lymphocytes play an important role in antitumour immunity. We examined the relationship between the minimum absolute lymphocyte counts (Min ALCs) during radiotherapy (RT) and clinical outcomes in patients with hepatocellular carcinoma (HCC). METHODS: Data from a total of 69 HCC patients who had received RT were retrospectively analysed. Peripheral blood lymphocytes were measured before RT, weekly during RT and after RT. Regression and mixed-effect models were used to assess the relationships with and potential predictors of overall survival (OS)...
February 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28202571/temporal-dynamics-of-retinal-and-extraretinal-signals-in-the-fefsem-during-smooth-pursuit-eye-movements
#14
Leah Bakst, Jerome Fleuriet, Michael J Mustari
Neurons in the smooth eye movement subregion of the Frontal Eye Field (FEFsem) are known to play an important role in voluntary smooth pursuit eye movements. Underlying this function are projections to parietal and prefrontal visual association areas and subcortical structures, all known to play vital, but differing roles in the execution of smooth pursuit. Additionally, the FEFsem has been shown to carry a diverse array of signals (e.g. eye velocity, acceleration, gain control). We hypothesized that distinct subpopulations of FEFsem neurons subserve these diverse functions and projections, and that the relative weights of retinal and extraretinal signals could form the basis for categorization of units...
February 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28199797/nutritional-risk-screening-2002-short-nutritional-assessment-questionnaire-malnutrition-screening-tool-and-malnutrition-universal-screening-tool-are-good-predictors-of-nutrition-risk-in-an-emergency-service
#15
Estela Iraci Rabito, Aline Marcadenti, Jaqueline da Silva Fink, Luciane Figueira, Flávia Moraes Silva
BACKGROUND: There is an international consensus that nutrition screening be performed at the hospital; however, there is no "best tool" for screening of malnutrition risk in hospitalized patients. OBJECTIVE: To evaluate (1) the accuracy of the MUST (Malnutrition Universal Screening Tool), MST (Malnutrition Screening Tool), and SNAQ (Short Nutritional Assessment Questionnaire) in comparison with the NRS-2002 (Nutritional Risk Screening 2002) to identify patients at risk of malnutrition and (2) the ability of these nutrition screening tools to predict morbidity and mortality...
February 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28197608/the-dynamic-mechanism-of-rassf5-and-mst-kinase-activation-by-ras
#16
Tsung-Jen Liao, Hyunbum Jang, Chung-Jung Tsai, David Fushman, Ruth Nussinov
As a tumor suppressor, RASSF5 (NORE1A) activates MST1/2 thereby modulating the Hippo pathway. Structurally, activation involves RASSF5 and MST1/2 swapping their SARAH domains to form a SARAH heterodimer. This exposes the MST1/2 kinase domain which homodimerizes, leading to trans-autophosphorylation. The SARAH-SARAH interaction shifts RASSF5 away from its autoinhibited state and relieves MST1/2 autoinhibition. Separate crystal structures are available for the RA (Ras association) domain and SARAH dimer, where SARAH is a long straight α-helix...
February 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28196647/the-dorsal-visual-stream-revisited-stable-circuits-or-dynamic-pathways
#17
REVIEW
Claudio Galletti, Patrizia Fattori
In both macaque and human brain, information regarding visual motion flows from the extrastriate area V6 along two different paths: a dorsolateral one towards areas MT/V5, MST, V3A, and a dorsomedial one towards the visuomotor areas of the superior parietal lobule (V6A, MIP, VIP). The dorsolateral visual stream is involved in many aspects of visual motion analysis, including the recognition of object motion and self motion. The dorsomedial stream uses visual motion information to continuously monitor the spatial location of objects while we are looking and/or moving around, to allow skilled reaching for and grasping of the objects in structured, dynamically changing environments...
January 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28196644/re-evaluation-of-epidermodysplasia-verruciformis-reconciling-more-than-90%C3%A2-years-of-debate
#18
REVIEW
Joanna Przybyszewska, Abraham Zlotogorski, Yuval Ramot
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to cutaneous human beta-papillomavirus infections causing persistent flat warts or pityriasis versicolor-like lesions. This generalized verrucous skin disorder resembles generalized verrucosis, but these 2 conditions are distinguished by differences in clinical manifestation and the human papillomavirus types involved. A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determine susceptibility to this disorder; however, they have not solved all EV cases fully...
February 10, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28186637/perceived-burdensomeness-thwarted-belongingness-and-fearlessness-about-death-associations-with-suicidal-ideation-among-female-veterans-exposed-to-military-sexual-trauma
#19
Lindsey L Monteith, Nazanin H Bahraini, Deleene S Menefee
OBJECTIVE: Military sexual trauma (MST) is prevalent among female Veterans and is associated with increased risk for suicidal self-directed violence. Yet research examining processes which contribute to suicidal ideation and attempts among MST survivors has been sparse, focusing primarily on psychiatric symptoms or diagnoses, rather than employing a theory-driven approach. The interpersonal-psychological theory (Joiner, 2005) is a leading theory of suicide that may be particularly relevant for understanding suicidal ideation among female Veterans who have experienced MST...
February 10, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28183853/mark4-inhibits-hippo-signaling-to-promote-proliferation-and-migration-of-breast-cancer-cells
#20
Emad Heidary Arash, Ahmed Shiban, Siyuan Song, Liliana Attisano
The Hippo pathway is a critical regulator of tissue size, and aberrations in pathway regulation lead to cancer. MST1/2 and LATS1/2 kinases comprise the core of the pathway that, in association with adaptor proteins SAV and MOB, functions in a sequential manner to phosphorylate and inhibit the transcription factors YAP and TAZ. Here we identify mammalian MARK family members as activators of YAP/TAZ. We show that depletion of MARK4 in MDA-MB-231 breast cancer cells results in the loss of nuclear YAP/TAZ and decreases the expression of YAP/TAZ targets...
February 9, 2017: EMBO Reports
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