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https://www.readbyqxmd.com/read/29147887/a-preliminary-prediction-model-for-potentially-guiding-patient-choices-between-breast-conserving-surgery-and-mastectomy-in-early-breast-cancer-patients-a-dutch-experience
#1
Elvira Vos, Linetta Koppert, Winnifred van Lankeren, Cornelis Verhoef, Bas Groot Koerkamp, Myriam Hunink
PURPOSE: To guide early stage breast cancer patients to choose between breast conserving surgery (BCS) and mastectomy (MST) considering the predicted cosmetic result and quality of life (QoL). METHODS: A decision model was built to compare QoL after BCS and MST. Treatment could result in BCS with good cosmesis, BCS with poor cosmesis, MST only, and MST with breast reconstruction. QoL for these treatment outcomes were obtained from a previous study and the literature and translated into EuroQoL-5D derived utilities...
November 17, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29141394/proximal-resection-margins-more-prognostic-than-distal-resection-margins-in-patients-undergoing-hilar-cholangiocarcinoma-resection
#2
Tae Yoo, Sang-Jae Park, Sung-Sik Han, Seong Hoon Kim, Seung Duk Lee, Tae Hyun Kim, Soon-Ae Lee, Sang Myung Woo, Woo Jin Lee, Eun Kyung Hong
Purpose: Even though the therapeutic gold standard of hilar cholangiocarcinoma(HCCA) resection is cancer-free resection margin(RM), surgical treatment still remains challenging. This study evaluated the prognostic significance of RM status in resected HCCA patients and identified survival prognostic factors. Materials and Methods: We reviewed records of 96 HCCA patients who underwent surgery from 2001 to 2012 and analyzed the RM status and prognostic factors that affecting survival...
November 16, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29138088/comparing-multilayer-brain-networks-between-groups-introducing-graph-metrics-and-recommendations
#3
Kanad Mandke, Jil Meier, Matthew J Brookes, Reuben D O'Dea, Piet Van Mieghem, Cornelis J Stam, Arjan Hillebrand, Prejaas Tewarie
There is an increasing awareness of the advantages of multi-modal neuroimaging. Networks obtained from different modalities are usually treated in isolation, which is however contradictory to accumulating evidence that these networks show non-trivial interdependencies. Even networks obtained from a single modality, such as frequency-band specific functional networks measured from magnetoencephalography (MEG) are often treated independently. Here, we discuss how a multilayer network framework allows for integration of multiple networks into a single network description and how graph metrics can be applied to quantify multilayer network organisation for group comparison...
November 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/29133753/transcatheter-arterial-chemoembolization-combined-with-simultaneous-computed-tomography-guided-radiofrequency-ablation-for-large-hepatocellular-carcinomas
#4
Tai-Yang Zuo, Feng-Yong Liu, Mao-Qiang Wang, Xian-Xian Chen
BACKGROUND: Currently, the treatment of large hepatocellular carcinoma (HCC) is still a challenging problem. Transcatheter arterial chemoembolization (TACE) is the main treatment for intermediate end-stage HCC, while it is only a palliative and not a curative treatment due to the existence of residual tumors, and radiofrequency ablation (RFA) has limitations in complete ablation of large HCC. We hypothesized that TACE combined with simultaneous RFA (herein referred to as TACE + RFA) could improve the efficacy and survival of large HCC...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29126560/assessment-of-fecal-pollution-in-lake-pontchartrain-louisiana
#5
Jia Xue, Siyu Lin, Frederica G Lamar, Jennifer G Lamori, Samendra Sherchan
Water quality in Lake Pontchartrain was deteriorating and recreational activities along the beach were restricted by the end of the 20th Century. A microbial source tracking (MST) study was conducted to determine the fecal contamination sources at public beach of the lake, so that effective pollution control strategies can be developed. Water samples were collected over an eight-month period at ten locations along the lake in 2016 and 2017. E. coli and Enterococcus were detected in 90.6% (culture) and 97.5% (qPCR), 95...
November 7, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29126270/neural-plasticity-with-age-unilateral-maximal-strength-training-augments-efferent-neural-drive-to-the-contralateral-limb-in-older-adults
#6
Tiril Tøien, Runar Unhjem, Thomas Storehaug Øren, Ann Charlotte Gjertsen Kvellestad, Jan Hoff, Eivind Wang
Efferent neural drive during strong muscle contractions is attenuated with age, even after lifelong strength training. However, it is unknown if this deterioration may impede contralateral neural plasticity, and limit the clinical value of unilateral strength training. We assessed muscle force-generating capacity, evoked potentials recordings (V-wave and H-reflex normalized to M-wave; V/M-ratio and H/M-ratio) and voluntary activation (VA) in the plantar flexors of the contralateral limb following unilateral maximal strength training (MST) with the dominant limb for three weeks (9 sessions)...
November 4, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29126203/a-randomized-phase-ii-study-of-everolimus-in-combination-with-chemoradiation-in-newly-diagnosed-glioblastoma-results-of-nrg-oncology-rtog-0913
#7
Prakash Chinnaiyan, Minhee Won, Patrick Y Wen, Amyn M Rojiani, Maria Werner-Wasik, Helen A Shih, Lynn S Ashby, Hsiang-Hsuan Michael Yu, Volker W Stieber, Shawn C Malone, John B Fiveash, Nimish A Mohile, Manmeet S Ahluwalia, Merideth M Wendland, Philip J Stella, Andrew Y Kee, Minesh P Mehta
Background: This Phase II study was designed to determine the efficacy of the mTOR inhibitor everolimus administered daily with conventional radiation therapy and chemotherapy in patients with newly diagnosed glioblastoma. Methods: Patients were randomized to radiation therapy with concurrent and adjuvant temozolomide with or without daily everolimus (10 mg). The primary endpoint was progression-free survival (PFS) and the secondary endpoints were overall survival (OS) and treatment-related toxicities...
November 6, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29122302/multiple-subpial-transections-and-magnetic-resonance-imaging
#8
P Finet, C Grandin, G Vaz, K Van Rijckevorsel, C Raftopoulos
INTRODUCTION: Multiple subpial transection (MST) has been applied to the treatment of refractory epilepsy when epileptogenic zone involves eloquent areas since 1989. However, there is a lack of data evaluating the effect of this surgical technique on the cortex as measured by Magnetic Resonance Imaging (MRI). PATIENTS AND METHODS: Ten consecutive patients (3F/7M, average age: 18.5 years) were operated on using radiating MST (average: 39; min: 19, max: 61) alone (n=3) or associated with another technique (n=7)...
November 6, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29120401/does-locoregional-chemotherapy-still-matter-in-the-treatment-of-advanced-pelvic-melanoma
#9
Stefano Guadagni, Giammaria Fiorentini, Marco Clementi, Giancarlo Palumbo, Paola Palumbo, Alessandro Chiominto, Stefano Baldoni, Francesco Masedu, Marco Valenti, Ambra Di Tommaso, Bianca Fabi, Camillo Aliberti, Donatella Sarti, Veronica Guadagni, Cristina Pellegrini
Pelvic Melanoma relapse occurs in 15% of patients with loco regional metastases, and 25% of cases do not respond to new target-therapy and/or immunotherapy. Melphalan hypoxic pelvic perfusion may, therefore, be an option for these non-responsive patients. Overall median survival time (MST), stratified for variables, including BRAF V600E mutation and eligibility for treatments with new immunotherapy drugs, was retrospectively assessed in 41 patients with pelvic melanoma loco regional metastases. They had received a total of 175 treatments with Melphalan hypoxic perfusion and cytoreductive excision...
November 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29115674/let-s-talk-parents-mental-talk-not-mind-mindedness-or-mindreading-capacity-predicts-children-s-false-belief-understanding
#10
Rory T Devine, Claire Hughes
Although one might expect parents' mind-mindedness (MM; the propensity to view children as mental agents) to relate to everyday mental-state talk (MST) and theory-of-mind capacity, evidence to support this view is lacking. In addition, both the uniqueness and the specificity of relations between parental MM, parental MST, and children's false belief understanding (FBU) are open to question. To address these three gaps, this study tracked 117 preschoolers (60 boys) and their parents across a 13-month period (Mage  = 3...
November 8, 2017: Child Development
https://www.readbyqxmd.com/read/29114693/estimating-the-probability-of-illness-due-to-swimming-in-recreational-water-with-a-mixture-of-human-and-gull-associated-microbial-source-tracking-markers
#11
Kendra I Brown, Katherine E Graham, Jeffrey A Soller, Alexandria B Boehm
Beaches often receive fecal contamination from more than one source. Human sources include untreated sewage as well as treated wastewater effluent, and animal sources include wildlife such as gulls. Different contamination sources are expected to pose different health risks to swimmers. Genetic microbial source tracking (MST) markers can be used to detect bacteria that are associated with different animal sources, but the health risks associated with a mixture of MST markers are unknown. This study presents a method for predicting these health risks, using human- and gull-associated markers as an example...
November 8, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29112385/models-for-unsymmetrical-active-sites-in-metalloproteins-structural-redox-and-magnetic-properties-of-bimetallic-complexes-with-m-ii-%C3%AE-oh-fe-iii-cores
#12
Yohei Sano, Nathanael Lau, Andrew C Weitz, Joseph W Ziller, Michael P Hendrich, A S Borovik
Bimetallic complexes are important sites in metalloproteins but are often difficult to prepare synthetically. We have previously introduced an approach to form discrete bimetallic complexes with M(II)-(μ-OH)-Fe(III) (M(II) = Mn, Fe) cores using the tripodal ligand N,N',N″-[2,2',2″-nitrilotris(ethane-2,1-diyl)]tris(2,4,6-trimethylbenzenesulfonamido) ([MST](3-)). This series is extended to include the rest of the late 3d transition metal ions (M(II) = Co, Ni, Cu, Zn). All of the bimetallic complexes have similar spectroscopic and structural properties that reflect little change despite varying the M(II) centers...
November 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29107641/genetic-coding-algorithm-for-sense-and-antisense-peptide-interactions
#13
Nikola Štambuk, Paško Konjevoda, Petra Turčić, Katalin Kövér, Renata Novak Kujundžić, Zoran Manojlović, Mario Gabričević
Sense and antisense peptides, i.e. peptides specified by complementary DNA and RNA sequences, interact with increased probability. Biro, Blalock, Mekler, Root-Bernstein and Siemion investigated the recognition rules of peptide-peptide interaction based on the complementary coding of DNA and RNA sequences in 3'→5' and 5'→3' directions. After more than three decades of theoretical and experimental investigations, the efficiency of this approach to predict peptide-peptide binding has been experimentally verified for more than 50 ligand-receptor systems, and represents a promising field of research...
October 28, 2017: Bio Systems
https://www.readbyqxmd.com/read/29107195/application-of-whole-genome-sequence-data-in-analyzing-the-molecular-epidemiology-of-shiga-toxin-producing-escherichia-coli-o157-h7-h
#14
Eiji Yokoyama, Shinichiro Hirai, Taichiro Ishige, Satoshi Murakami
Seventeen clusters of Shiga toxin-producing Escherichia coli O157:H7/- (O157) strains, determined by cluster analysis of pulsed-field gel electrophoresis patterns, were analyzed using whole genome sequence (WGS) data to investigate this pathogen's molecular epidemiology. The 17 clusters included 136 strains containing strains from nine outbreaks, with each outbreak caused by a single source contaminated with the organism, as shown by epidemiological contact surveys. WGS data of these strains were used to identify single nucleotide polymorphisms (SNPs) by two methods: short read data were directly mapped to a reference genome (mapping derived SNPs) and common SNPs between the mapping derived SNPs and SNPs in assembled data of short read data (common SNPs)...
October 17, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29104622/comparison-of-effectiveness-and-adverse-effects-of-gefitinib-erlotinib-and-icotinib-among-patients-with-non-small-cell-lung-cancer-a-network-meta-analysis
#15
Yuanyuan Liu, Yu Zhang, Gangling Feng, Qiang Niu, Shangzhi Xu, Yizhong Yan, Shugang Li, Mingxia Jing
The present network meta-analysis aimed to compare the effectiveness and adverse effects of gefitinib, erlotinib and icotinib in the treatment of patients with non-small cell lung cancer (NSCLC). Two reviewers searched the Cochrane, PubMed, Embase, ScienceDirect, China National Knowledge Infrastructure, VIP Database for Chinese Technical Periodicals and Wanfang databases for relevant studies. Studies were then screened and evaluated, and data was extracted. End-points evaluated for NSCLC included complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD), overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), median survival time (MST) and adverse effects, including rash, diarrhea, nausea and vomiting, fatigue and abnormal liver function...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29103858/mental-stress-peripheral-vascular-reactivity-is-elevated-in-women-with-coronary-vascular-dysfunction-results-from-the-nhlbi-sponsored-cardiac-autonomic-nervous-system-cans-study
#16
Puja K Mehta, Melody Hermel, Michael D Nelson, Galen Cook-Wiens, Elizabeth A Martin, Ayman A Alkhoder, Janet Wei, Margo Minissian, Chrisandra L Shufelt, Sailaja Marpuri, David Hermel, Amit Shah, Michael R Irwin, David S Krantz, Amir Lerman, C Noel Bairey Merz
BACKGROUND: Women with chest pain, ischemia, and no obstructive coronary artery disease often have coronary vascular dysfunction (CVaD). Peripheral vascular reactivity to mental stress may contribute mechanistic understanding of stress-induced ischemia in women with CVaD. METHODS: 62 women (41 CVaD and 21 controls) underwent mental stress testing (MST) with anger recall, mental arithmetic, and forehead cold pressor (COP) challenge. Emotional arousal was measured (Likert scale)...
October 22, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29103772/high-aldh1a1-expression-indicates-a-poor-prognosis-in-gastric-neuroendocrine-carcinoma
#17
Yuhong Ye, Sheng Zhang, Yupeng Chen, Xingfu Wang, Pengcheng Wang
OBJECTIVE: To evaluate the expression and prognostic significance of ALDH1A1 in gastric neuroendocrine carcinoma. MATERIALS AND METHODS: Immunohistochemical stains of ALDH1A1 were evaluated in 67 cases of gastric neuroendocrine carcinoma. The findings were correlated with clinicopathologic variables and overall survival. RESULTS: Immunohistochemistry revealed positive cytoplasmic immunoreactivity in 35 of 67 (52.2%) tumors and strongly positive immunoreactivity in 14 of 67 (20...
October 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29102988/clinical-and-economic-evaluation-of-modulated-electrohyperthermia-concurrent-to-dose-dense-temozolomide-21-28-days-regimen-in-the-treatment-of-recurrent-glioblastoma-a-retrospective-analysis-of-a-two-centre-german-cohort-trial-with-systematic-comparison-and
#18
Sergey V Roussakow
OBJECTIVE: To assess the efficacy and cost-effectiveness of modulated electrohyperthermia (mEHT) concurrent to dose-dense temozolomide (ddTMZ) 21/28 days regimen versus ddTMZ 21/28 days alone in patients with recurrent glioblastoma (GBM). DESIGN: A cohort of 54 patients with recurrent GBM treated with ddTMZ+mEHT in 2000-2005 was systematically retrospectively compared with five pooled ddTMZ 21/28 days cohorts (114 patients) enrolled in 2008-2013. RESULTS: The ddTMZ+mEHT cohort had a not significantly improved mean survival time (mST) versus the comparator (p=0...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29101564/first-experience-with-the-autolap%C3%A2-system-an-image-based-robotic-camera-steering-device
#19
Paul J M Wijsman, Ivo A M J Broeders, Hylke J Brenkman, Amir Szold, Antonello Forgione, Henk W R Schreuder, Esther C J Consten, Werner A Draaisma, Paul M Verheijen, Jelle P Ruurda, Yuval Kaufman
BACKGROUND: Robotic camera holders for endoscopic surgery have been available for 20 years but market penetration is low. The current camera holders are controlled by voice, joystick, eyeball tracking, or head movements, and this type of steering has proven to be successful but excessive disturbance of surgical workflow has blocked widespread introduction. The Autolap™ system (MST, Israel) uses a radically different steering concept based on image analysis. This may improve acceptance by smooth, interactive, and fast steering...
November 3, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29100024/towards-repositioning-of-quinacrine-for-treatment-of-acute-myeloid-leukemia-promising-synergies-and-in-vivo-effects
#20
Anna Eriksson, Efthymia Chantzi, Mårten Fryknäs, Joachim Gullbo, Peter Nygren, Mats Gustafsson, Martin Höglund, Rolf Larsson
We previously reported that the anti-malarial drug quinacrine has potential to be repositioned for treatment of acute myeloid leukemia (AML). As a next step towards clinical use, we assessed the efficacy of quinacrine in an AML-PS mouse model and investigated possible synergistic effects when combining quinacrine with nine other antileukemic compounds in two AML cell lines. Furthermore, we explored the in vivo activity of quinacrine in combination with the widely used AML agent cytarabine. The in vivo use of quinacrine (100mg/kg three times per week for two consecutive weeks) significantly suppressed circulating blast cells at days 30/31 and increased the median survival time (MST)...
October 28, 2017: Leukemia Research
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