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Fetal fibronectin

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https://www.readbyqxmd.com/read/29447720/no-257-ultrasonographic-cervical-length-assessment-in-predicting-preterm-birth-in-singleton-pregnancies
#1
Kenneth Lim, Kimberly Butt, Joan M Crane
OBJECTIVES: To review (1) the use of ultrasonographic-derived cervical length measurement in predicting preterm birth and (2) interventions associated with a short cervical length. OUTCOMES: Reduction in rates of prematurity and/or better identification of those at risk, as well as possible prevention of unnecessary interventions. EVIDENCE: Published literature was retrieved through searches of PubMed and The Cochrane Library up to December 2009, using appropriate controlled vocabulary and key words (preterm labour, ultrasound, cervix, incompetent cervix, transvaginal, transperineal, cervical length, fibronectin)...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29408625/maternal-and-neonatal-irisin-precursor-gene-fndc5-polymorphism-is-associated-with-preterm-birth
#2
Hagit Salem, Yekaterina Yatchenko, Mariana Anosov, Talya Rosenfeld, Gheona Altarescu, Sorina Grisaru-Granovsky, Ruth Birk
Irisin is a novel secreted myokine, encoded by the fibronectin type III domain-containing protein 5 (FNDC5) precursor gene. Irisin plays a role in the female reproductive system in pregnancy and in embryonic development, and is associated with fetal size. It is expressed in the ovary, placenta and neonatal cord serum. We studied whether maternal and neonatal FNDC5 genetic polymorphisms are associated with preterm birth (PTB). Blood for DNA analysis was collected from Israeli mothers (n = 315) and from umbilical veins of their respected idiopathic preterm (24-36 weeks) and control term (>37 weeks) newborns (n = 161)...
January 30, 2018: Gene
https://www.readbyqxmd.com/read/29391455/accuracy-of-fetal-fibronectin-for-the-prediction-of-preterm-birth-in-symptomatic-twin-pregnancies-a-pilot-study
#3
Florent Fuchs, Clémentine Lefevre, Marie-Victoire Senat, Hervé Fernandez
Our goal was to evaluate the performance of fetal fibronectin (fFN) test alone or combined with cervical length (CL), to predict spontaneous preterm birth (PTB) in symptomatic twin pregnancies. We carry out a short pilot study including all uncomplicated diamniotic twin pregnancies with symptoms of preterm labor (PTL) and intact membranes at 24-33 weeks + 6 days of gestation. Studied outcome were spontaneous delivery within 7 and 14 days of testing and spontaneous PTB at <34 and <37 weeks of gestation...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29367099/mid-gestational-changes-in-cervicovaginal-fluid-cytokine-levels-in-asymptomatic-pregnant-women-are-predictive-markers-of-inflammation-associated-spontaneous-preterm-birth
#4
Emmanuel Amabebe, David R Chapman, Victoria L Stern, Graham Stafford, Dilly O C Anumba
OBJECTIVES: Perturbation of the choriodecidual space before the onset of spontaneous preterm birth (sPTB) could lead to a concomitant rise in both cervicovaginal fluid (CVF) cytokine and fetal fibronectin (FFN), and assessing the concentrations of both markers could improve the prediction of sPTB (delivery before 37 completed weeks of gestation). Therefore, we prospectively determined mid-trimester changes in CVF cytokine and FFN concentrations, and their predictive capacity for sPTB in asymptomatic pregnant women...
January 10, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29355887/accuracy-of-fetal-fibronectin-for-assessing-preterm-birth-risk-in-asymptomatic-pregnant-women-a-systematic-review-and-meta-analysis
#5
Francois Dos Santos, Jahnavi Daru, Ewelina Rogozińska, Natalie A M Cooper
INTRODUCTION: Fetal fibronectin (fFN) is a validated test for assessing risk of preterm birth for women presenting with symptoms. Our aim was to evaluate the accuracy of fFN to detect the risk of preterm birth in asymptomatic women. MATERIAL AND METHODS: Searches were conducted to identify studies where fFN was performed in asymptomatic women beyond 22 weeks' gestation. EMBASE, MEDLINE, CINHAL, AMED and BNI were searched between 2005 and 2017. Studies before 2005 were identified from a published systematic review...
January 21, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29325073/the-women-s-health-diagnostic-gap
#6
Ann M Gronowski, Melanie L Yarbrough
Pregnancy remains a significant health risk to women in both developed and underdeveloped countries. Worldwide, 10 to 20 million women have pregnancy complications including ectopic pregnancy, preterm birth, gestational diabetes mellitus, and hypertensive states, including preeclampsia. Despite advancements in women's health research, there is a large gap in the diagnostic tools available to screen, diagnose, and monitor these conditions. Herein, we examine existing diagnostic tools, such as the human chorionic gonadotropin discriminatory zone, cervicovaginal fetal fibronectin, sFlt-1:PlGF ratio, and glucose tolerance testing...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29297659/fetal-fibronectin-testing-and-pregnancy-outcomes-among-texas-medicaid-patients-at-risk-for-preterm-birth
#7
Jamie C Barner, Allison A Petrilla, Hyeun Ah Kang, Xian Shen, Ahmed M Alshehri, Erin M Sullivan, Kathleen A Troeger, Kristin M Richards, Sean C Blackwell
OBJECTIVES: Fetal fibronectin (fFN) testing between the 24th and 34th weeks of pregnancy in patients with symptomatic preterm labor (PTL) helps assess the risk of spontaneous preterm birth (sPTB), yet the extent of its use is unknown. We assessed use of fFN testing among Texas Medicaid enrollees with symptomatic PTL and evaluated time to infant delivery and healthcare utilization/costs. STUDY DESIGN: Retrospective cohort study using medical and pharmacy claims for Texas Medicaid enrollees...
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29297658/current-perspectives-on-the-use-of-fetal-fibronectin-testing-in-preterm-labor-diagnosis-and-management
#8
Michael S Ruma, Katie C Bittner, Clara B Soh
One in 10 infants in the United States is delivered preterm (ie, before the 37th week of pregnancy), contributing to the significant burden on the national healthcare system. Nevertheless, a lack of agreement continues among obstetric professional societies on guidelines for standardization of the approach to the diagnosis and management of patients with symptoms of preterm labor (PTL). This disparity in consensus has likely resulted in poor identification of women at an increased risk for preterm birth (PTB)...
December 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29275278/increasing-compliance-with-a-clinical-practice-guideline-for-fetal-fibronectin-testing-and-the-management-of-threatened-preterm-labour-a-quality-improvement-project
#9
Lisa K Dawes, Malini Subramoney, Laura M Miller, Katie M Groom
OBJECTIVE: To increase adherence to a local hospital clinical practice guideline for the use of fetal fibronectin testing in women presenting with symptoms of threatened preterm labour. STUDY DESIGN: A quality improvement project using a multi-faceted implementation strategy. SETTING: National Women's Health, Auckland City Hospital; a tertiary referral maternity unit in Auckland, New Zealand. POPULATION: All obstetricians, junior obstetric doctors and hospital employed midwives...
December 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29232957/quartz-crystal-microbalance-with-dissipation-as-a-biosensing-platform-to-evaluate-cell-surface-interactions-of-osteoblast-cells
#10
Abdulhalim Kılıç, Fatma Nese Kok
Quartz crystal microbalance with dissipation (QCM-D) is one of the powerful techniques, which allow real time, quantitative and noninvasive analysis of the interaction of different cell types with various modified surfaces. In this study, the dynamic adhesion behavior of human fetal osteoblastic bone (hfOB) cell lines was first monitored on untreated and hydrophilically treated gold sensor surfaces as reference substrates. Adhesion was also observed under light microscopy to facilitate the evaluation. Cells increased their surface contact area and spread more on hydrophilic surfaces, and showed distinct profile with an increased rigidity at the interfacial layer, which is assigned to extracellular matrix remodeling...
December 12, 2017: Biointerphases
https://www.readbyqxmd.com/read/29212380/%C3%AE-v%C3%AE-3-integrin-and-fibronectin-expressions-and-their-relation-to-estrogen-and-progesterone-during-placentation-in-swine
#11
C Vélez, C Barbeito, M Koncurat
Mammalian pregnancy requires specific interactions between the conceptus and its mother that involve the endocrine system and adhesion molecules. The relation between adhesion molecules and their ligands at the fetal-maternal interface is crucial for developing a successful implantation. Progesterone (P4) and estrogen (E2) secreted by the porcine conceptus are required for the relation to be established. We investigated the expression of αvβ3 integrin and its ligand, fibronectin (FN), at the placental interface, and E2 and P4 concentrations in both serum and maternal and fetal placental extracts during placentation in swine...
December 7, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29177680/measuring-the-adhesion-limit-of-fibronectin-for-fibroblasts-with-a-narrow-gap-rotational-rheometer
#12
Haider Dakhil, Hung Do, Holger Hübner, Andreas Wierschem
We study the adhesion limit of 3T6 fibroblasts, cultured in Dulbecco's modified Eagle's medium with 10% fetal bovine serum at 37 °C and 5% CO2, with a narrow-gap rotational rheometer in the parallel-disk configuration. Reducing the uncertainty in gap width to about 1 µm allows studying the cells at narrow gaps, which enables to study the critical shear stress of the cells in low-viscous media. The adhesion limit on fibronectin-coated glass plates is determined as a function of concentration and adhesion time...
November 25, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29164819/decellularized-bovine-cotyledons-may-serve-as-biological-scaffolds-with-preserved-vascular-arrangement
#13
Rodrigo da Silva Nunes Barreto, Patricia Romagnolli, Andrea Maria Mess, Maria Angelica Miglino
Technically produced scaffolds are common to establish transplantable tissues for Regenerative Medicine, but also biological ones that are closer to the natural condition become of interest. Placentas are promising, because they represented available, complete organs with rich extracellular matrix (ECM) and well developed vasculature that easily could build anastomoses to a host´s organ. Only placentas from larger animal models such as the bovine meet the dimensions large enough for most organs, but are not adequately described yet...
November 21, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29112664/placental-alpha-microglobulin-1-compared-with-fetal-fibronectin-to-predict-preterm-delivery-in-symptomatic-women
#14
Deborah A Wing, Sina Haeri, Angela C Silber, Cheryl K Roth, Carl P Weiner, Nelson C Echebiri, Albert Franco, Lanissa M Pappas, John D Yeast, Angelle A Brebnor, J Gerald Quirk, Aisling M Murphy, Louise C Laurent, Nancy T Field, Mary E Norton
OBJECTIVE: To compare the rapid bedside test for placental α microglobulin-1 with the instrumented fetal fibronectin test for prediction of imminent spontaneous preterm delivery among women with symptoms of preterm labor. METHODS: We conducted a prospective observational study on pregnant women with signs or symptoms suggestive of preterm labor between 24 and 35 weeks of gestation with intact membranes and cervical dilatation less than 3 cm. Participants were prospectively enrolled at 15 U...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29042802/utilization-of-fetal-fibronectin-testing-and-pregnancy-outcomes-among-women-with-symptoms-of-preterm-labor
#15
Sean C Blackwell, Erin M Sullivan, Allison A Petrilla, Xian Shen, Kathleen A Troeger, James D Byrne
OBJECTIVES: To identify pregnant health plan members triaged through the emergency department (ED), including labor and delivery (ELD) units, with symptoms of preterm labor (PTL), and evaluate the use of fetal fibronectin (fFN) testing; and to calculate the rate of hospitalization and timing of delivery in relation to the ED visit. METHODS: Retrospective cohort study using Medical Outcomes Research for Effectiveness and Economics Registry(®), a national multipayer claims database...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28935263/predicting-preterm-birth-cervical-length-and-fetal-fibronectin
#16
REVIEW
Moeun Son, Emily S Miller
Spontaneous preterm birth remains the leading cause of neonatal morbidity and mortality worldwide, and accounts for a significant global health burden. Several obstetric strategies to screen for spontaneous preterm delivery, such as cervical length and fetal fibronectin measurement, have emerged. However, the effectiveness of these strategies relies on their ability to accurately predict those pregnancies at increased risk for spontaneous preterm birth (SPTB). Transvaginal cervical shortening is predictive of preterm birth and when coupled with appropriate preterm birth prevention strategies, has been associated with reductions in SPTB in asymptomatic women with a singleton gestation...
December 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/28910845/the-association-between-fetal-fibronectin-cervical-length-and-amniotic-fluid-sludge-with-histological-indicators-of-placental-inflammation-in-twin-gestations
#17
Aboluwade Ayodele, Nathan S Fox, Simi Gupta, Jessica Spiegelman, Daniel H Saltzman, Whitney Booker, Andrei Rebarber
No abstract text is available yet for this article.
September 14, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28880936/reduced-microrna-503-expression-augments-lung-fibroblast-vegf-production-in-chronic-obstructive-pulmonary-disease
#18
Jun Ikari, Amy J Nelson, Jannah Obaid, Alvaro Giron-Martinez, Kumiko Ikari, Fumihiko Makino, Shunichiro Iwasawa, Yoko Gunji, Maha Farid, Xingqi Wang, Hesham Basma, Dawn Demeo, Carol Feghali-Bostwick, Olaf Holz, Klaus Rabe, Xiangde Liu, Stephen I Rennard
Alterations in microRNA (miRNA) expression may contribute to COPD pathogenesis. In COPD, lung fibroblast repair functions are altered in multiple ways, including extracellular mediator release. Our prior study revealed miR-503 expression is decreased in COPD lung fibroblasts, although the exact role played by miR-503 is undetermined. The current study examined a role of miR-503 in cytokine, growth factor and fibronectin production by lung fibroblasts from patients with and without COPD. Primary adult lung fibroblasts were isolated from patients with or without COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28855236/serial-transvaginal-cervical-length-measurements-and-quantitative-vaginal-fetal-fibronectin-concentrations-did-not-predict-spontaneous-preterm-birth-in-low-risk-nulliparous-women
#19
https://www.readbyqxmd.com/read/28776905/expression-of-cytokine-and-extracellular-matrix-mrnas-in-fetal-hepatic-stellate-cells
#20
Keai Sinn Tan, Kasem Kulkeaw, Yoichi Nakanishi, Daisuke Sugiyama
In mouse fetal liver, hepatoblasts, sinusoidal endothelial cells and macrophages (or erythroblastic islands) promote differentiation and proliferation of hematopoietic cells through cell-cell interactions and secretion of cytokines and extracellular matrix factors. Until now, we have had little knowledge of the hematopoietic cytokines or extracellular matrix mRNAs expressed in hepatic stellate cells. Using p75 neurotrophin receptor (p75NTR) to mark this cell population, we sorted 12.5, 14.5 and 16.5 dpc hepatic stellate cells and analyzed expression of cytokines and extracellular matrix mRNAs...
September 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
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