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Luisa F Polania, Lalit K Mestha, David T Huang, Jean-Philippe Couderc
Advances in mobile computing and miniature devices have contributed to the accelerated development of wearable technologies for clinical applications. The new trend of wearable technologies has fostered a growth of interest for sensors that can be easily integrated into wearable devices. In particular, photoplethysmography (PPG) is especially suitable for wearable sensing, as it is low-cost, noninvasive, and does not require wet electrodes like the electrocardiogram. Photoplethysmograph signals contain rich information about the blood pulsating variation which is strongly related to the electrical activities of the heart...
2015: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Jennefir L Digaum, Javier J Pazos, Jeffrey Chiles, Jeffrey D'Archangel, Gabriel Padilla, Adrian Tatulian, Raymond C Rumpf, Sasan Fathpour, Glenn D Boreman, Stephen M Kuebler
Spatially-variant photonic crystals (SVPCs), in which the orientation of the unit cell changes as a function of position, are shown to be capable of abruptly controlling light beams using just low index materials and can be made to have high polarization selectivity. Multi-photon direct laser writing in the photo-polymer SU-8 was used to fabricate three-dimensional SVPCs that direct the flow of light around a 90 degree bend. The lattice spacing and fill factor were maintained nearly constant throughout the structure...
October 20, 2014: Optics Express
Christian Diestelhorst, Joachim Boos, Jeannine S McCune, Georg Hempel
PURPOSE: We developed a new population pharmacokinetic (PopPK) model for intravenous (i.v.) busulfan in children to evaluate the optimal method to personalize its dosing without concentration-time data. METHODS: PopPK analyses were done with NONMEM® 7.2. First, a model from Trame et al. was evaluated using an external dataset consisting of 24 children. Second, a revised model was built in a separate dataset of 82 children. Model evaluation was performed by using a standardized visual predictive check (SVPC) procedure and a bootstrap analysis (internal evaluation) and by comparison to an external dataset (external validation)...
July 2014: European Journal of Clinical Pharmacology
Ozan Yazici, Sercan Aksoy, Ozgul Ucar, Nuriye Ozdemir, Mevlut Demir, Mehmet Ali Nahit Sendur, Zafer Arik, Sebnem Yaman, Tulay Eren, Dogan Uncu, Nurullah Zengin
Zoledronic acid (ZA) is one of the important bisphosphonates which is widely used in bone metastatic cancer and osteoporotic patients. In a few studies, it has been reported that treatment with bisphosphonates was associated with an increased risk of atrial fibrillation. We aimed to evaluate the arrhythmias that developed during and immediately after infusion of the ZA. Fifty-two bone metastatic patients were included in the study group. All patients had 24-h Holter monitorization during the first dose ZA infusion day...
2013: Medical Oncology
Gudrun Würthwein, Oliver A Cornely, Mirjam N Trame, Janne J Vehreschild, Maria J G T Vehreschild, Fedja Farowski, Carsten Müller, Joachim Boos, Georg Hempel, Michael Hallek, Andreas H Groll
Caspofungin (CAS) is approved for second-line management of proven or probable invasive aspergillosis at a dose of 50 mg once daily (QD). Preclinical and limited clinical data support the concept of the dose-dependent antifungal efficacy of CAS with preservation of its favorable safety profile. Little is known, however, about the pharmacokinetics (PKs) of higher doses of CAS in patients. In a formal multicenter phase II dose-escalation study, CAS was administered as a 2-h infusion at doses ranging from 70 to 200 mg QD...
April 2013: Antimicrobial Agents and Chemotherapy
Martin Petzoldt, Carsten Riedel, Jan Braeunig, Sebastian Haas, Matthias S Goepfert, Hendrik Treede, Stephan Baldus, Alwin E Goetz, Daniel A Reuter
PURPOSE: Transcardiopulmonary thermodilution (TPTD, SVTD) as well as calibrated (SVPC CAL) and uncalibrated (SVPC UNCAL) arterial pulse contour analysis (PC) are increasingly promoted as less-invasive technologies to measure stroke volume (SV) but their reliability in aortic valve disease was unknown. The objective of this prospective study was to investigate the validity of three less-invasive techniques to assess SV in conditions involving aortic stenosis (AS) and valvuloplasty-induced aortic insufficiency (AI) compared with transesophageal echocardiography...
April 2013: Intensive Care Medicine
Diane D Wang, Shuzhong Zhang
The visual predictive check (VPC) is a commonly used approach in model evaluation. However, it may not be feasible to conduct a VPC, or the results of a VPC could be misleading in certain situations. The objectives of the present study were to (1) examine the performance and applicability of the VPC and (2) propose the standardized visual predictive check (SVPC) as an alternative/complementary approach to the VPC. The difference between the SVPC and normalized prediction distribution error (npde) as visual tools for model evaluation is also discussed...
January 2012: Journal of Clinical Pharmacology
Müjgan Tek, Yüksel Cavuşoğlu, Canan Demirüstü, Alparslan Birdane, Ahmet Ünalır, Bülent Görenek, Ömer Göktekin, Necmi Ata
OBJECTIVES: Unlike traditional inotropic agents, levosimendan is thought to have a lower potential to induce arrhythmias because it does not increase intracellular calcium levels and myocardial oxygen consumption. We compared the potential effect of levosimendan and dobutamine to induce cardiac arrhythmias in patients with decompensated heart failure. STUDY DESIGN: Fifty patients with acute decompensated heart failure (NYHA class III-IV, ejection fraction <35%) who were in need of inotropic support were randomized to dobutamine (n=25; mean age 69±10 years) or levosimendan (n=25; mean age 67...
July 2010: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Andrea Benedetto Galosi, Vito Lacetera
UNLABELLED: INTRODUCTION. It is not well known how many Small Volume Prostate Cancers (SVPC) may host high grade (Gleason pattern 4/5) or have extraprostatic extension in particular in the national setting. Features of SVPC are very interesting since they raise controversies in diagnosis and have important clinical implications in treatment strategies. The diagnosis may be difficult and the treatment ranges from active surveillance to radical surgery. AIM. We evaluate clinical and pathological features of SVPC in surgical specimens of patients who underwent biopsy and radical prostatectomy...
October 2009: Urologia
Asif Cahangirov, Ahmet Cihan, Nergis Murat, Omer Demir, Guven Aslan, Sedef Gidener, Ahmet Adil Esen
INTRODUCTION: Association between hyperthyroidism and premature ejaculation was demonstrated in clinical studies. AIM: The aim of this study is to determine the target level of changes on ejaculatory physiology under hyperthyroid states. METHODS: p-Chloroamphetamine (PCA)-induced pharmacologic ejaculation model with 24 male Wistar rats was used in the study. Subcutaneous injection of L-thyroxine for 14 days was performed to induce hyperthyroidism...
January 2011: Journal of Sexual Medicine
I M van Oort, Dieuwertje E G Kok, Lambertus A Kiemeney, Christina A Hulsbergen-van de Kaa, J Alfred Witjes
OBJECTIVE: Small volume prostate cancers (<0.5 cc, svPC), and insignificant prostate cancers (<0.5 cc and Gleason scores <7, InsigPC) are considered clinically insignificant by some investigators. The aim of this study is to determine the biochemical recurrence rate (BCR) of svPC and InsigPC in prostatectomy specimens. METHODS: In total, 502 patients with prostate cancer, treated with radical prostatectomy (RP) between 1992 and 2005 and with detailed pathological classification, were included in the present study...
September 2009: Urologic Oncology
Bhulaxmi Madur, Tanuja Shet, Roshni Chinoy
OBJECTIVE: To examine the observation that some mucinous carcinomas have a micropapillary pattern and are mucinous variants of the highly angioinvasive infiltrating micropapillary carcinomas (IMPC). STUDY DESIGN: We evaluated cytologic findings of 13 IMPC and 55 mucinous carcinomas for comparative features. RESULTS: In mucinous carcinomas, 37 of 50 (74%) had a micropapillary pattern. This group included 27 cases with pure mucinous micropapillary morphology (MUMPC), 8 MUMPC associated with a ductal carcinoma of the IMPC type (MUIDC) and 2 cases of mixed mucinous carcinomas with an MUMPC and a solid variant ofpapillary carcinoma (SVPC) component...
January 2007: Acta Cytologica
M Matsumoto, Z Fujii, Y Kawata, T Sakumura, M Minami, K Fujimoto, C Nawata, M Matsuzaki
Appropriate dosing of pilsicainide hydrochloride, an anti-arrhythmic drug excreted via the kidney, was investigated in patients on dialysis. Ten chronic hemodialysis patients with coexisting severe palpitation of supraventricular premature contractions (SVPC) were treated with 25 mg of pilsicainide hydrochloride before dialysis. All of their plasma concentrations were maintained within the therapeutic range and their mean dialysis rate was 32%. After 2 weeks, 7 patients were followed with consecutive daily dose treatment...
June 2001: Nephron
T Tanabe, H Furuya, N Kanemoto, H Tomoda, H Sasamoto
Holter system electrocardiograms were recorded for 617 patients who were treated at the Department of Cardiology, Tokai University Hospital. In cases of arrhythmia, ventricular premature contraction (VPC) was the most predominant, in 291 cases (69%) out of 423 with arrhythmia, followed by 59 (14%) with supraventricular premature contraction (SVPC), 23 (5.4%) with paroxysmal atrial tachycardia, 17 (4%) with second degree A-V block and 10 (2.3%) with transient atrial fibrillation (AF). In addition, nine (2.1%) cases of ventricular tachycardia (VT), one (0...
January 1980: Tokai Journal of Experimental and Clinical Medicine
T Oki, M Asai, H Takemura, N Fukuda, H Sakai, C Ohshima, T Tominaga, M Taoka, T Niki, H Mori
To investigate the possibility for detection of atrio-ventricular (A-V) regurgitation in arrhythmias non-invasively, we recorded velocity patterns of blood flow at the inflow tract of the right (RVI) and left ventricles (LVI), and at the outflow tract of the left ventricle (LVO) by pulsed Doppler echocardiography in 32 patients with various types of arrhythmia. They were six cases with supraventricular premature contraction (SVPC), 13 with ventricular premature contraction (VPC), two with second degree A-V block, five with complete A-V block and six with artificial right ventricular pacemaker...
September 1983: Journal of Cardiography
F G Nowak, G Cocco, D Chu, D F Gasser
Twenty coronary patients with a median age of 76 years were treated in the coronary care unit with tiapamil, a new Ca2+ antagonist, by intravenous infusion (until December, 1979, the generic name was dimeditiapramine). The following arrhythmias were identified: atrial fibrillation with ventricular rate greater than 95 beats/min (5 patients); supraventricular premature complexes (SVPC) (4 patients); and ventricular premature complexes (VPC), Lown grades 2-4 (15 patients). Electrocardiograms and hemodynamic parameters were continuously monitored prior to, during, and after the therapy...
December 1980: Clinical Cardiology
C Sekiguchi, M Iwane, M Oshibuchi
Recently developed high-performance fighter aircraft (HPF) are capable of producing high sustained +Gz (HSG) with a rapid onset rate. This G-producing capability is now beyond human physiologic G tolerance. Many techniques to raise the tolerance to HSG have been used operationally. In order to cope with HSG effectively, the Japanese Air Self Defense Force has given high-G training for certain fighter pilots since 1982. So far, 138 pilots (62 F-15 Trainees, 76 F-4 Trainees) have completed centrifuge training at our laboratory...
November 1986: Aviation, Space, and Environmental Medicine
M Motomochi, H Handa, Y Yonekawa, K Taki, S Nagasawa, T Konishi
Forty three expired cases due to ruptured cerebral aneurysm were studied in electrocardiographic alterations with special reference to other complications of the autonomic nervous system. The cases with past history of ischemic cardiovascular disease had been excluded. The age of the patients ranged between 23 to 79 years old (average 50.1 years old). The clinical condition of the patients according to Hunt & Kosnik classification I in 1 case, II in 11 cases, III in 14 cases, and IV & V in 17 cases. The duration between the aneurysm rupture and admission was within 24 hours in 16 cases, 2 to 3 days in 13 cases, 4 to 7 days in 9 cases, and 2 to 3 weeks in 5 cases...
July 1986: Nō to Shinkei, Brain and Nerve
A Poukkula, U R Korhonen, H Huikuri, M Linnaluoto
We compared the frequency and severity of cardiac arrhythmias during combined oral theophylline and inhaled salbutamol vs. salbutamol therapy alone in 18 patients with moderate to severe chronic obstructive pulmonary disease who had concurrent cardiac disease. Seventeen patients showed at least one supraventricular premature complex (SVPC) on the 24-h ECG recording when receiving salbutamol alone: eight patients had isolated SVPCs, less than 10/h; five patients had greater than or equal to 10 SVPCs/h; eight patients showed runs of supraventricular tachycardia or paroxysmal atrial fibrillation...
October 1989: Journal of Internal Medicine
M Nagashima, M Matsushima, A Ogawa, A Ohsuga, T Kaneko, T Yazaki, M Okajima
Ambulatory electrocardiographic monitoring was performed on 360 healthy children, from newborn infants to junior high school students. They were divided into five groups by age: group A, 63 newborn infants on the first day of life; group B, 50 infants aged 1-11 months; group C, 53 kindergarten pupils aged 4-6 years; group D, 97 primary school pupils aged 9-12 years; and group E, 97 junior high school students aged 13-15 years. The maximal and minimal heart rates were significantly greater in infants than in older children...
1987: Pediatric Cardiology
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