keyword
https://read.qxmd.com/read/36520094/association-of-vitamin-d-receptor-polymorphisms-with-cardiometabolic-conditions-in-pakistani-population
#21
JOURNAL ARTICLE
Humera Fiaz, Abdul Rehman Khan, Shahid Abbas, Ahmed Bilal, Haq Nawaz Khan, Misbah Hussain, Fazli Rabbi Awan
<b/>Apart from bone related effects, vitamin D has roles in immune modulation, hypertension, diabetes and cardiovascular diseases. Metabolic functions of vitamin D are mediated after binding with vitamin D receptor (VDR). VDR polymorphisms affect its physiological functions. Several VDR single nucleotide polymorphisms (SNPs) are reported previously. However, VDR polymorphisms causing influence on cardiovascular and metabolic disorders have not been investigated in Pakistani population so far. Therefore, present study was conducted to evaluate the role of VDR polymorphisms (rs2228570 and rs7975232) in the pathobiology of cardiometabolic disorders...
December 15, 2022: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://read.qxmd.com/read/36387403/integration-analysis-of-metabolome-and-transcriptome-reveals-the-effect-of-exogenous-supplementation-with-mixtures-of-vitamins-ade-zinc-and-selenium-on-follicular-growth-and-granulosa-cells-molecular-metabolism-in-donkeys-equus-asinus
#22
JOURNAL ARTICLE
Yajun Guo, Weisen Zhao, Nan Li, Shizhen Dai, Hao Wu, Zhenlong Wu, Shenming Zeng
Vitamins and microelements play essential roles in mammalian ovarian physiology, including follicle development, ovulation, and synthesis and secretion of hormones and growth factors. However, it is nevertheless elusive to what extent exogenous supplementation with mixtures of vitamins ADE, zinc (Zn), and selenium (Se) affects follicular growth and granulosa cells (GCs) molecular function. We herein investigated their effect on follicular growth and GCs physiological function. We showed that follicular growth and ovulation time was accelerated and shortened with the increases of vitamins ADE, Zn, and Se doses by continually monitoring and recording (one estrus cycle of about 21 days) with an ultrasound scanner...
2022: Frontiers in Veterinary Science
https://read.qxmd.com/read/36009040/adenine-induced-nephropathy-reduces-atherosclerosis-in-apoe-knockout-mice
#23
JOURNAL ARTICLE
Laeticia Scherler, Sofia N Verouti, Daniel Ackermann, Bruno Vogt, Geneviève Escher
BACKGROUND: Cardiovascular events are the main cause of death in patients with chronic kidney disease. We hypothesize that the protective effects of renal cholesterol and vitamin D3 metabolism are lost under this condition. Nephropathy was induced by adenine in Apolipoprotein E knockout mice. The atherosclerotic phenotype was compared to mice with normal renal function. METHODS: Mice were fed a western diet ±0.15% adenine. Urine and feces were collected to assess renal function and fecal output...
August 19, 2022: Biomolecules
https://read.qxmd.com/read/35726330/paricalcitol-attenuates-metabolic-syndrome-associated-heart-failure-through-enhanced-mitochondrial-fusion
#24
JOURNAL ARTICLE
Hina L Nizami, Parmeshwar B Katare, Pankaj Prabhakar, Ramu Adela, Soumalya Sarkar, Sudheer Arava, Praloy Chakraborty, Subir K Maulik, Sanjay K Banerjee
Objectives: Transition from cardiac hypertrophy to failure involves adverse metabolic reprogramming involving mitochondrial dysfunction. We have earlier shown that vitamin D deficiency induces heart failure, at least in part, through insulin resistance. However, whether activation of vitamin D receptor (VDR) can attenuate heart failure and underlying metabolic phenotype requires investigation. Thus, we aimed to assess the cardioprotective potential of paricalcitol, a vitamin D receptor-activator, against cardiac hypertrophy and failure in high-fat high-fructose-fed rats...
2022: Oxidative Medicine and Cellular Longevity
https://read.qxmd.com/read/35646540/bile-acid-coordinates-microbiota-homeostasis-and-systemic-immunometabolism-in-cardiometabolic-diseases
#25
REVIEW
Baoyi Guan, Jinlin Tong, Haiping Hao, Zhixu Yang, Keji Chen, Hao Xu, Anlu Wang
Cardiometabolic disease (CMD), characterized with metabolic disorder triggered cardiovascular events, is a leading cause of death and disability. Metabolic disorders trigger chronic low-grade inflammation, and actually, a new concept of metaflammation has been proposed to define the state of metabolism connected with immunological adaptations. Amongst the continuously increased list of systemic metabolites in regulation of immune system, bile acids (BAs) represent a distinct class of metabolites implicated in the whole process of CMD development because of its multifaceted roles in shaping systemic immunometabolism...
May 2022: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/35598688/vitamin-d-receptor-affects-male-mouse-fertility-via-regulation-of-lipid-metabolism-and-testosterone-biosynthesis-in-testis
#26
JOURNAL ARTICLE
Ling Wang, Hongzhao Lu, Shanshan Wang, Huan Liu, Miaomiao Guo, Hao Bai, Wenxian Zeng, Tao Zhang
Vitamin D and vitamin D receptor (VD/VDR) plays a vital role in the development of spermatozoa, which is largely determined by the testosterone level in serum. Testosterone biosynthesis is closely related to lipid metabolism in gonadal adipose around testes. VDR could regulate lipid metabolism in adipocytes as well. However, it still remains unknown how VDR regulates lipid metabolism to impact testosterone biosynthesis in testis. Hereby, various parameters of male fertility were compared between wildtype (WT) and Vdr knockout (Vdr-KO) male mouse...
August 5, 2022: Gene
https://read.qxmd.com/read/35565211/bone-progenitors-pull-the-strings-on-the-early-metabolic-rewiring-occurring-in-prostate-cancer-cells
#27
JOURNAL ARTICLE
Pablo Sanchis, Nicolas Anselmino, Sofia Lage-Vickers, Agustina Sabater, Rosario Lavignolle, Estefania Labanca, Peter D A Shepherd, Juan Bizzotto, Ayelen Toro, Antonina Mitrofanova, Maria Pia Valacco, Nora Navone, Elba Vazquez, Javier Cotignola, Geraldine Gueron
Metastatic prostate cancer (PCa) cells soiling in the bone require a metabolic adaptation. Here, we identified the metabolic genes fueling the seeding of PCa in the bone niche. Using a transwell co-culture system of PCa (PC3) and bone progenitor cells (MC3T3 or Raw264.7), we assessed the transcriptome of PC3 cells modulated by soluble factors released from bone precursors. In a Principal Component Analysis using transcriptomic data from human PCa samples (GSE74685), the altered metabolic genes found in vitro were able to stratify PCa patients in two defined groups: primary PCa and bone metastasis, confirmed by an unsupervised clustering analysis...
April 21, 2022: Cancers
https://read.qxmd.com/read/35554975/intergenerational-inheritance-of-altered-metabolism-phenotypes-after-early-life-stress-in-caenorhabditis-elegans
#28
JOURNAL ARTICLE
Sarah E Hall
Environmental stress experienced during critical periods of animal development has been shown to impact adult phenotypes through changes in behavior or physiology. In humans, undernutrition in utero can lead to obesity and metabolic disorders in adulthood that can be inherited for two generations in the absence of the original stress. However, how particular stresses can result in tissue-specific changes in target gene expression, and how that gene expression can be inherited, is not well understood. We have established Caenorhabditis elegans nematodes as a model system to investigate the molecular mechanisms that regulate environmental programming of gene expression...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35406129/elimination-of-vitamin-d-signaling-causes-increased-mortality-in-a-model-of-overactivation-of-the-insulin-receptor-role-of-lipid-metabolism
#29
JOURNAL ARTICLE
Maria Crespo-Masip, Aurora Perez-Gomez, Alicia Garcia-Carrasco, Ramiro Jover, Carla Guzmán, Xavier Dolcet, Mercé Ibarz, Cristina Martínez, Àuria Eritja, Juan Miguel Diaz-Tocados, José Manuel Valdivielso
Vitamin D (VD) deficiency has been associated with cancer and diabetes. Insulin signaling through the insulin receptor (IR) stimulates cellular responses by activating the PI3K/AKT pathway. PTEN is a tumor suppressor and a negative regulator of the pathway. Its absence enhances insulin signaling leading to hypoglycemia, a dangerous complication found after insulin overdose. We analyzed the effect of VD signaling in a model of overactivation of the IR. We generated inducible double KO (DKO) mice for the VD receptor (VDR) and PTEN...
April 5, 2022: Nutrients
https://read.qxmd.com/read/35127371/therapeutic-regulation-of-autophagy-in-hepatic-metabolism
#30
REVIEW
Katherine Byrnes, Sophia Blessinger, Niani Tiaye Bailey, Russell Scaife, Gang Liu, Bilon Khambu
Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especially relevant in the liver, a key metabolic organ that governs body energy metabolism. Autophagy's role in hepatic energy regulation has just begun to emerge and autophagy seems to have a much broader impact than what has been appreciated in the field. Though classically known for selective or bulk degradation of cellular components or energy-dense macromolecules, emerging evidence indicates autophagy selectively regulates various signaling proteins to directly impact the expression levels of metabolic enzymes or their upstream regulators...
January 2022: Acta Pharmaceutica Sinica. B
https://read.qxmd.com/read/35032589/therapeutic-effect-of-patrinia-villosa-on-tnbs-induced-ulcerative-colitis-via-metabolism-vitamin-d-receptor-and-nf-%C3%AE%C2%BAb-signaling-pathways
#31
JOURNAL ARTICLE
Jiaqi Wang, Xin Wang, Xiande Ma, Baoli Xu, Lijiang Chen, Changlan Chen, Wei Liu, Yangcheng Liu, Zheng Xiang
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a chronic inflammatory disease affecting the colon. Patrinia villosa Juss. (P.V) is an important traditional Chinese medicine widely used for more than 2000 years from ShenNongBenCaoJing, a famous ancient Chinese medicinal literary. P.V is often used in the treatment of UC, but the pathogenesis is not clear. AIM OF THE STUDY: This study was designed to analysis the metabolic pathways and relevant mechanisms of P...
January 12, 2022: Journal of Ethnopharmacology
https://read.qxmd.com/read/34827697/impact-of-vitamin-d-3-deficiency-on-phosphatidylcholine-ethanolamine-plasmalogen-lyso-phosphatidylcholine-ethanolamine-carnitine-and-triacyl-glyceride-homeostasis-in-neuroblastoma-cells-and-murine-brain
#32
JOURNAL ARTICLE
Anna Andrea Lauer, Lea Victoria Griebsch, Sabrina Melanie Pilz, Daniel Janitschke, Elena Leoni Theiss, Jörg Reichrath, Christian Herr, Christoph Beisswenger, Robert Bals, Teresa Giovanna Valencak, Dorothea Portius, Heike Sabine Grimm, Tobias Hartmann, Marcus Otto Walter Grimm
Vitamin D3 hypovitaminosis is associated with several neurological diseases such as Alzheimer's disease, Parkinson's disease or multiple sclerosis but also with other diseases such as cancer, diabetes or diseases linked to inflammatory processes. Importantly, in all of these diseases lipids have at least a disease modifying effect. Besides its well-known property to modulate gene-expression via the VDR-receptor, less is known if vitamin D hypovitaminosis influences lipid homeostasis and if these potential changes contribute to the pathology of the diseases themselves...
November 15, 2021: Biomolecules
https://read.qxmd.com/read/34502478/caspase-1-inhibition-impacts-the-formation-of-chondrogenic-nodules-and-the-expression-of-markers-related-to-osteogenic-differentiation-and-lipid-metabolism
#33
JOURNAL ARTICLE
Alice Ramesova, Barbora Vesela, Eva Svandova, Herve Lesot, Eva Matalova
Caspase-1, as the main pro-inflammatory cysteine protease, was investigated mostly with respect to inflammation-related processes. Interestingly, caspase-1 was identified as being involved in lipid metabolism, which is extremely important for the proper differentiation of chondrocytes. Based on a screening investigation, general caspase inhibition impacts the expression of Cd36 in chondrocytes, the fatty acid translocase with a significant impact on lipid metabolism. However, the engagement of individual caspases in the effect has not yet been identified...
September 3, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34304574/relationship-between-bsmi-polymorphism-and-vdr-gene-methylation-profile-gender-metabolic-profile-oxidative-stress-and-inflammation-in-adolescents
#34
JOURNAL ARTICLE
Lavoisiana Lacerda de Lucena, Alexandre Sérgio Silva, Rayner Anderson Ferreira do Nascimento, Darlene Camati Persuhn, Juliana Padilha Ramos Neves, Maria José Carvalho Costa, Dayana Joyce Marques Queiroz, Rafaela Lira Formiga Covalcanti de Lima, Raquel Patrícia Ataíde de Lima, Maria Paula de Paiva, Naila Francis Paulo de Oliveira, Maria da Conceição Rodrigues Gonçalves
Background: the biological activity of vitamin D depends on the activity of its receptor or VDR. On the other hand, the activity of this receptor is influenced by its state of methylation. The objective of this study was to verify if the BsmI polymorphism of the VDR gene influences its methylation profile in adolescents. Secondly, it was to verify if the status of some metabolic factors (oxidative stress, inflammation, lipid profile, and glycemia) in the serum, and gender-adjusted vitamin D levels are independent factors with an influence on the VDR methylation profile...
October 13, 2021: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://read.qxmd.com/read/34008880/association-of-vitamin-d-receptor-polymorphisms-with-metabolic-syndrome-related-components-a-cross-sectional-study
#35
JOURNAL ARTICLE
Ting Jin, Weina Lu, Xiaoqin Gong, Jiaqiang Zhou, Fang Wu
BACKGROUND: The association between vitamin D receptor (VDR) polymorphisms and metabolic syndrome (MS) has been demonstrated by epidemiological studies while their correlation remain controversial. The aim of this study is to investigate the association of VDR gene polymorphisms with MS and MS-related components in the two communities of Hangzhou. METHODS: A total of 394 subjects were enrolled in the cross-sectional study. Four VDR gene polymorphisms (ApaI, BsmI, FokI, and TaqI) were selected based on human genome sequence databases and genotyped using the MassARRAY Analyzer Compact...
July 2021: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/33836827/molecular-mechanisms-of-vitamin-d-plus-bisphenol-a-effects-on-adipogenesis-in-human-adipose-derived-mesenchymal-stem-cells
#36
JOURNAL ARTICLE
Amin Salehpour, Farzad Shidfar, Mehdi Hedayati, Ali Asghar Farshad, Asal Neshatbini Tehrani, Saeed Mohammadi
BACKGROUND: Obesity is considered a major health concern and mounting evidence suggests that the exposure to environmental endocrine disruptors, including Bisphenol-A (BPA), may enhance the risk to develop the disease. Moreover, growing documents propose that the vitamin D may contribute to adipogenic signaling and lipid accumulation during adipocyte differentiation. We focused on the molecular mechanism of vitamin D and BPA in human adipose-derived mesenchymal stem cells (hADMSCs) which vitamin D and BPA may influence adipose tissue development and function...
April 9, 2021: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/33636214/bile-acids-and-their-receptors-in-metabolic-disorders
#37
REVIEW
Stefano Fiorucci, Eleonora Distrutti, Adriana Carino, Angela Zampella, Michele Biagioli
Bile acids are a large family of atypical steroids which exert their functions by binding to a family of ubiquitous cell membrane and nuclear receptors. There are two main bile acid activated receptors, FXR and GPBAR1, that are exclusively activated by bile acids, while other receptors CAR, LXRs, PXR, RORγT, S1PR2and VDR are activated by bile acids in addition to other more selective endogenous ligands. In the intestine, activation of FXR and GPBAR1 promotes the release of FGF15/19 and GLP1 which integrate their signaling with direct effects exerted by theother receptors in target tissues...
February 23, 2021: Progress in Lipid Research
https://read.qxmd.com/read/33626539/impact-of-vitamin-d-and-vitamin-d-receptor-on-risk-of-cardiovascular-diseases-in-children-and-adolescents-with-obesity-in-sichuan-china-a-cross-sectional-study
#38
JOURNAL ARTICLE
Hongjian Xie, Min Min, Siqi Guo, Yang Xian, Fan Yang, Xia Wang, Yali Cui, Yingying Li, Xiaojuan Liu
BACKGROUND: Previous studies have demonstrated the close relationship between vitamin D, vitamin D receptor (VDR), and obesity. Nevertheless, few studies have reported wherther the relationship among these is associated with the risk of cardiovascular diseases (CVDs) in Chinese children and adolescents. OBJECTIVE: The present study aimed to reveal the effects of obesity, serum vitamin D levels, and VDR FokI genotype on the risk of CVDs in children and adolescents in Sichuan, China...
February 24, 2021: Annals of Nutrition & Metabolism
https://read.qxmd.com/read/33603421/the-associations-between-vitamin-d-receptor-bsmi-and-apai-polymorphisms-and-obesity-in-korean-patients-with-type-2-diabetes-mellitus
#39
JOURNAL ARTICLE
Sang Won Nam, Jinwoo Choi, Hyun Jeong Jeon, Tae Keun Oh, Dong-Hwa Lee
Background: Vitamin D receptor ( VDR ) polymorphisms are associated with osteoporosis, diabetes, immunological diseases, and cancers. However, the association of obesity with VDR polymorphisms has shown inconsistent results, and perhaps it depends upon the characteristics of a population. Therefore, we evaluated the association between BsmI (rs1544410) and ApaI (rs7975232) polymorphisms of VDR and obesity in Korean patients with type 2 diabetes mellitus (T2DM). Methods: A total of 506 patients with T2DM participated in the study...
2021: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/33453499/l-carnitine-exerts-a-nutrigenomic-effect-via-direct-modulation-of-nuclear-receptor-signaling-in-adipocytes-hepatocytes-and-skmc-demonstrating-its-nutritional-impact
#40
JOURNAL ARTICLE
Lorenz Förster, Dominic Indra, Klemens Rosenberger, Lars Zver, Reinhold Hofbauer
L-carnitine is an indispensable metabolite facilitating the transport of fatty acids into the mitochondrial matrix and has been previously postulated to exert a nutrigenomic effect. However, the underlying molecular mechanisms remain mostly unclear. We hypothesized that L-carnitine interacts with nuclear receptors involved in metabolic regulation, thereby modulating downstream targets of cellular metabolism. Therefore, we investigated the effect of L-carnitine supplementation on protein activity, mRNA expression, and binding affinities of nuclear receptors as well as mRNA expression of downstream targets in skeletal muscle cells, hepatocytes, and differentiated adipocytes...
January 2021: Nutrition Research
keyword
keyword
6302
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.