Ruolan Liu, Yao Lu, Xuyan Peng, Jingyi Jia, Yonglin Ruan, Shengchi Shi, Tingting Shu, Tianhui Li, Xia Jin, Gang Zhai, Jiangyan He, Qiyong Lou, Zhan Yin
INTRODUCTION: 1α,25-dihydroxyvitamin D3 (1α,25[OH]2 VD3 ) is a hormone known for its key roles in calcium absorption and nutrient metabolism. In teleost fishes, 1α,25(OH)2 VD3 insufficiency causes impaired glucose metabolism and lipid oxidation. However, the cascade and mechanisms of 1α,25(OH)2 VD3 and the vitamin d receptor (VDR) signaling are unclear. RESULTS: In this study, two genes ( vdra and vdrb ) encoding paralogs of VDRs were genetically knocked out in zebrafish...
2023: Frontiers in Endocrinology