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Vdr lipid metabolism

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https://www.readbyqxmd.com/read/27811935/integrated-computational-approach-to-the-analysis-of-rna-seq-data-reveals-new-transcriptional-regulators-of-psoriasis
#1
Alena Zolotarenko, Evgeny Chekalin, Alexandre Mesentsev, Ludmila Kiseleva, Elena Gribanova, Rohini Mehta, Ancha Baranova, Tatiana V Tatarinova, Eleonora S Piruzian, Sergey Bruskin
Psoriasis is a common inflammatory skin disease with complex etiology and chronic progression. To provide novel insights into the regulatory molecular mechanisms of the disease, we performed RNA sequencing analysis of 14 pairs of skin samples collected from patients with psoriasis. Subsequent pathway analysis and extraction of the transcriptional regulators governing psoriasis-associated pathways was executed using a combination of the MetaCore Interactome enrichment tool and the cisExpress algorithm, followed by comparison to a set of previously described psoriasis response elements...
November 4, 2016: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/27504197/effect-of-exercise-on-serum-vitamin-d-and-tissue-vitamin-d-receptors-in-experimentally-induced-type-2-diabetes-mellitus
#2
Yosria E Aly, Azza S Abdou, Mona M Rashad, Menatallah M Nassef
This work aimed to study the effect of swimming exercise on serum vitamin D level and tissue vitamin D receptors in experimentally induced type 2 Diabetes Mellitus. Sixty adult male rats were divided into control and diabetic groups. Each was further subdivided into sedentary and exercised subgroups. Diabetes Mellitus was induced by a single intraperitoneal dose of streptozotocin (50 mg/kg) dissolved in cold 0.01 M citrate buffer (pH 4.5). The exercised subgroups underwent swimming for 60 min, 5 times a week for 4 weeks...
September 2016: Journal of Advanced Research
https://www.readbyqxmd.com/read/27483726/vitamin-d-and-tissular-expression-of-vitamin-d-receptor-in-obesity
#3
Raluca Haliga, F Zugun-Eloae, T Oboroceanu, A Pînzariu, Veronica Mocanu
Vitamin D (VitD), a lipid-soluble hormone, is able to regulate the transcription of many genes through vitamin D receptor (vitD receptor-VDR). It has been shown that VitD deficiency is associated with obesity, characterized by a low degree inflammatory state, which contribute to the pathogeny of metabolic syndrome and type 2 diabetes mellitus. VitD deficiency is a public health problem, at the same time the global prevalence of obesity and cardiovascular diseases is continuously growing. Evidence from recent studies on animal models suggest that VitD or VDR deficiency promotes cardiomyocyte hypertrophy, which can be one of the mechanisms for increasing cardiovascular risk...
April 2016: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
https://www.readbyqxmd.com/read/27473111/vitamin-d3-vdr-resists-diet-induced-obesity-by-modulating-ucp3-expression-in-muscles
#4
Yue Fan, Kumi Futawaka, Rie Koyama, Yuki Fukuda, Misa Hayashi, Miyuki Imamoto, Takashi Miyawaki, Masato Kasahara, Tetsuya Tagami, Kenji Moriyama
BACKGROUND: The impact of vitamin D3 (VD3) on obesity has been reported in the past. Our study was aimed at investigating the possible mechanisms by which VD3 affects obesity induced by a high fat diet. METHODS: Eight-week-old C57BL/6 J male mice were fed a normal- or high-fat diet for 9 weeks and were treated with a gavage of vehicle (corn oil) or cholecalciferol (50 μg/kg, daily). Body weight, white adipose tissue weight, blood lipid and glucose levels were measured...
2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27245430/hepatocyte-vitamin-d-receptor-regulates-lipid-metabolism-and-mediates-experimental-diet-induced-steatosis
#5
Milica Bozic, Carla Guzmán, Marta Benet, Sonia Sánchez-Campos, Carmelo García-Monzón, Eloi Gari, Sonia Gatius, José Manuel Valdivielso, Ramiro Jover
BACKGROUND & AIMS: The pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD) is still incompletely understood. Several nuclear receptors play a role in liver lipid metabolism and can promote hepatosteatosis, but the possible role of vitamin D receptor (VDR) in NAFLD has not been investigated. METHODS: The expression of liver VDR was investigated in apolipoprotein E knockout (apoE(-/-)) mice on a high fat diet, in wild-type mice on methionine and choline deficient diet and in NAFLD patients with hepatosteatosis and non-alcoholic steatohepatitis...
October 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27234962/pro-inflammatory-signaling-by-24-25-dihydroxyvitamin-d3-in-hepg2-cells
#6
Kent Wehmeier, Luisa M Onstead-Haas, Norman C W Wong, Arshag D Mooradian, Michael J Haas
The vitamin D metabolite 24,25-dihydroxyvitamin D3 (24, 25[OH]2D3) was shown to induce nongenomic signaling pathways in resting zone chondrocytes and other cells involved in bone remodeling. Recently, our laboratory demonstrated that 24,25-[OH]2D3 but not 25-hydroxyvitamin D3, suppresses apolipoprotein A-I (apo A-I) gene expression and high-density lipoprotein (HDL) secretion in hepatocytes. Since 24,25-[OH]2D3 has low affinity for the vitamin D receptor (VDR) and little is known with regard to how 24,25-[OH]2D3 modulates nongenomic signaling in hepatocytes, we investigated the capacity of 24,25-[OH]2D3 to activate various signaling pathways relevant to apo A-I synthesis in HepG2 cells...
August 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27100371/study-and-evaluation-the-impact-of-vdr-variants-on-the-risk-of-t2dm-in-han-chinese
#7
Fei Yu, Chong Jian Wang, Ling Wang, Hong Lin Jiang, Yue Ba, Ling Ling Cui, Yan Wang, Song Cheng Yu, Wen Jie Li
BACKGROUND: Vitamin D and VDR have been shown to be associated with the susceptibility of T2DM. The purpose of this study was to screen more SNPs in VDR and assess their impacts on the risk of T2DM in Han Chinese. METHOD: Four SNPs were genotyped in 1191 individuals (397 cases and 794 controls). Allele frequencies and genotype distributions were analyzed. The effects had been investigated about the genotype distribution of SNPs on the levels of phenotypes, insulin resistance and β-cell function of patients...
April 21, 2016: Journal of Diabetes
https://www.readbyqxmd.com/read/26870934/nuclear-receptor-modulation-for-the-treatment-of-nonalcoholic-fatty-liver-disease
#8
Claudia D Fuchs, Stefan A Traussnigg, Michael Trauner
Nuclear receptors (NRs) are ligand-activated transcriptional regulators of several key metabolic processes including hepatic lipid and glucose metabolism, bile acid homeostasis, and energy expenditure as well as inflammation, fibrosis, and cellular proliferation in the liver. Dysregulation of these processes contributes to the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD). This places NRs at the forefront of novel therapeutic approaches for NAFLD. Some NRs are already pharmacologically targeted in metabolic disorders such as hyperlipidemia (peroxisomal proliferator-activated receptor α [PPARα], fibrates) and diabetes (PPARγ, glitazones) with potential applications for NAFLD...
February 2016: Seminars in Liver Disease
https://www.readbyqxmd.com/read/26483964/genomic-study-of-cardiovascular-continuum-comorbidity
#9
O A Makeeva, A A Sleptsov, E V Kulish, O L Barbarash, A M Mazur, E B Prokhorchuk, N N Chekanov, V A Stepanov, V P Puzyrev
Comorbidity or a combination of several diseases in the same individual is a common and widely investigated phenomenon. However, the genetic background for non-random disease combinations is not fully understood. Modern technologies and approaches to genomic data analysis enable the investigation of the genetic profile of patients burdened with several diseases (polypathia, disease conglomerates) and its comparison with the profiles of patients with single diseases. An association study featuring three groups of patients with various combinations of cardiovascular disorders and a control group of relatively healthy individuals was conducted...
July 2015: Acta Naturae
https://www.readbyqxmd.com/read/26471398/aging-and-a-long-term-diabetes-mellitus-increase-expression-of-1-%C3%AE-hydroxylase-and-vitamin-d-receptors-in-the-rat-liver
#10
Ana Vuica, Lejla Ferhatović Hamzić, Katarina Vukojević, Milka Jerić, Livia Puljak, Ivica Grković, Natalija Filipović
Diabetes mellitus (DM) is a metabolic disorder associated with serious liver complications. As a metabolic chronic disease, DM is very common in the elderly. Recent studies suggest ameliorating effects of vitamin D on metabolic and oxidative stress in the liver tissue in an experimental model of DM. The aim of this study was to investigate the expression of vitamin D receptors (VDRs) and 1α-hydroxylase, the key enzyme for the production of active vitamin D form (calcitriol) in the liver during long-term diabetes mellitus type 1 (DM1) in aging rats...
December 2015: Experimental Gerontology
https://www.readbyqxmd.com/read/26383043/nuclear-hormone-receptors-roles-of-xenobiotic-detoxification-and-sterol-homeostasis-in-healthy-aging
#11
REVIEW
Julia Marianne Hoffmann, Linda Partridge
Health during aging can be improved by genetic, dietary and pharmacological interventions. Many of these increase resistance to various stressors, including xenobiotics. Up-regulation of xenobiotic detoxification genes is a transcriptomic signature shared by long-lived nematodes, flies and mice, suggesting that protection of cells from toxicity of xenobiotics may contribute to longevity. Expression of genes involved in xenobiotic detoxification is controlled by evolutionarily conserved transcriptional regulators...
2015: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/26142253/a-therapeutic-role-for-vitamin-d-on-obesity-associated-inflammation-and-weight-loss-intervention
#12
REVIEW
Aaron L Slusher, Matthew J McAllister, Chun-Jung Huang
Vitamin D plays an essential role in the regulation of skeletal metabolism as well as calcium and phosphate homeostasis, while vitamin D receptor (VDR) regulates de novo lipid synthesis, thereby contributing to the development of obesity. Furthermore, obese individuals are at a greater risk for vitamin D deficiency which may increase the potential risk for chronic inflammation, insulin resistance, and metabolic syndrome. While acute exercise enhances the activation of inflammatory signaling pathways, chronic exercise training may attenuate elevated pro-inflammatory cytokine production, resulting in the improvement of cardiovascular and metabolic health in obese individuals...
August 2015: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/26131079/cardioprotective-role-of-vitamin-d-receptor-in-circulating-endothelial-cells-of-apoe-deficient-mice
#13
Yan Ding, Wang Liao, Zhuwen Yi, Wei Xiang, Xiaojie He
Atherosclerosis is the key course of coronary heart disease. In this study, we investigated the effect of vitamin D receptor on serum 1,25-(OH)2D levels, lipid profiles, nitric oxide expression, apoptosis-related gene Bcl-2, fas protein levels, in ApoE-deficient mice. The proliferation activity of VDR-RNAi transfected endothelial cells was decreased, the ability of apoptosis was increased, nitric oxide concentration was decreased and eNOS protein level was significantly reduced. VDR-RNAi induced lipid metabolism abnormality, reduced eNOS and ApoE levels, promoted lipid peroxidation, damaged the endothelial function and accelerated the process of atheroscleros...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26045270/nuclear-receptors-in-acute-and-chronic-cholestasis
#14
REVIEW
Ester Gonzalez-Sanchez, Delphine Firrincieli, Chantal Housset, Nicolas Chignard
BACKGROUND: Nuclear receptors (NRs) form a family of 48 members. NRs control hepatic processes such as bile acid homeostasis, lipid metabolism and mechanisms involved in fibrosis and inflammation. Due to their central role in the regulation of hepatoprotective mechanisms, NRs are promising therapeutic targets in cholestatic disorders. KEY MESSAGES: NRs can be classified into five different physiological clusters. NRs from the 'bile acids and xenobiotic metabolism' and from the 'lipid metabolism and energy homeostasis' clusters are strongly expressed in the liver...
2015: Digestive Diseases
https://www.readbyqxmd.com/read/26010336/mitochondrial-and-lipogenic-effects-of-vitamin-d-on-differentiating-and-proliferating-human-keratinocytes
#15
Marco Consiglio, Marta Viano, Stefania Casarin, Carlotta Castagnoli, Gianpiero Pescarmona, Francesca Silvagno
Even in cells that are resistant to the differentiating effects of vitamin D, the activated vitamin D receptor (VDR) can downregulate the mitochondrial respiratory chain and sustain cell growth through enhancing the activity of biosynthetic pathways. The aim of this study was to investigate whether vitamin D is effective also in modulating mitochondria and biosynthetic metabolism of differentiating cells. We compared the effect of vitamin D on two cellular models: the primary human keratinocytes, differentiating and sensitive to the genomic action of VDR, and the human keratinocyte cell line HaCaT, characterized by a rapid growth and resistance to vitamin D...
October 2015: Experimental Dermatology
https://www.readbyqxmd.com/read/25606437/association-of-vitamin-d-and-vitamin-d-receptor-gene-polymorphisms-with-chronic-inflammation-insulin-resistance-and-metabolic-syndrome-components-in-type-2-diabetic-egyptian-patients
#16
Amal M H Mackawy, Mohammed E H Badawi
BACKGROUND: To date the published data concerning the possible interplay between vitamin D (VitD) and Vit D receptor (VDR) gene polymorphism with the immune/inflammatory mediators in type 2 diabetes mellitus (DM) is insufficient. Some of the immune non-classical actions of vitamin D may point to its role in the pathogenesis of type 2 DM through down-regulation of cytokines (IL-6). Although there is evidence to support a relationship among vitamin D status, chronic inflammation and insulin resistance, the underlying mechanism requires further exploration...
December 2014: Meta Gene
https://www.readbyqxmd.com/read/25498546/genetic-variants-of-vitamin-d-receptor-and-susceptibility-to-ischemic-stroke
#17
Puttachandra Prabhakar, Vijaya Majumdar, Girish Baburao Kulkarni, Rita Christopher
Vitamin D receptor (VDR) is a potential candidate for cardiovascular disease. To date the genetic association of VDR with ischemic stroke has not been explored. In the present study we aimed to evaluate the association between VDR gene variants and ischemic stroke in Asian Indian population. Overall, 557 subjects were investigated that included 313 ischemic stroke patients and 244 control subjects. Four single nucleotide polymorphisms of the VDR gene termed as Fok I, Apa I, Taq I and Bsm I were genotyped by using PCR-RFLP method...
January 9, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24899504/cutting-edge-vitamin-d-regulates-lipid-metabolism-in-mycobacterium-tuberculosis-infection
#18
Hugh Salamon, Natalie Bruiners, Karim Lakehal, Lanbo Shi, Janani Ravi, Ken D Yamaguchi, Richard Pine, Maria Laura Gennaro
Vitamin D has long been linked to resistance to tuberculosis, an infectious respiratory disease that is increasingly hard to treat because of multidrug resistance. Previous work established that vitamin D induces macrophage antimicrobial functions against Mycobacterium tuberculosis. In this article, we report a novel, metabolic role for vitamin D in tuberculosis identified through integrated transcriptome and mechanistic studies. Transcriptome analysis revealed an association between vitamin D receptor (VDR) and lipid metabolism in human tuberculosis and infected macrophages...
July 1, 2014: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/24860512/vitamin-d-intermediary-metabolism-and-prostate-cancer-tumor-progression
#19
REVIEW
Wei-Lin W Wang, Martin Tenniswood
Epidemiological data have demonstrated an inverse association between serum vitamin D3 levels, cancer incidence and related mortality. However, the effects of vitamin D on prostate cancer biology and its utility for prevention of prostate cancer progression are not as well-defined. The data are often conflicting: some reports suggest that vitamin D3 induces apoptosis in androgen dependent prostate cancer cell lines, while others suggest that vitamin D3 only induces cell cycle arrest. Recent molecular studies have identified an extensive synergistic crosstalk between the vitamin D- and androgen-mediated mRNA and miRNA expression, adding an additional layer of post-transcriptional regulation to the known VDR- and AR-regulated gene activation...
2014: Frontiers in Physiology
https://www.readbyqxmd.com/read/24582179/interaction-between-vitamin-d-receptor-gene-polymorphisms-and-25-hydroxyvitamin-d-concentrations-on-metabolic-and-cardiovascular-disease-outcomes
#20
K S Vimaleswaran, C Power, E Hyppönen
AIM: 25-hydroxyvitamin D (25OHD) concentrations have been shown to be associated with major clinical outcomes, with a suggestion that individual risk may vary according to common genetic differences in the vitamin D receptor (VDR) gene. Hence, we tested for the interactions between two previously studied VDR polymorphisms and 25OHD on metabolic and cardiovascular disease-related outcomes in a large population-based study. METHODS: Interactions between two previously studied VDR polymorphisms (rs7968585 and rs2239179) and 25OHD concentrations on metabolic and cardiovascular disease-related outcomes such as obesity- (body mass index, waist circumference, waist-hip ratio (WHR)), cardiovascular- (systolic and diastolic blood pressure), lipid- (high- and low-density lipoprotein, triglycerides, total cholesterol), inflammatory- (C-reactive protein, fibrinogen, insulin growth factor-1, tissue plasminogen activator) and diabetes- (glycated haemoglobin) related markers were examined in the 1958 British Birth cohort (n up to 5160)...
November 2014: Diabetes & Metabolism
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