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Multiple Axis 1 Diagnoses

Mary de Groot, Kent A Crick, Molly Long, Chandan Saha, Jay H Shubrook
OBJECTIVE: Depression in patients with type 2 diabetes (T2D) is associated with long-term complications, disability, and early mortality. No studies have systematically examined the length of episodes and remission in adults with major depressive disorder (MDD) and T2D. This study examined the course of depressive disorders in patients with T2D and MDD. RESEARCH DESIGN AND METHODS: Participants (N = 50) enrolled in a behavioral intervention for adults with T2D and MDD were interviewed using the Structured Clinical Interview for DSM-IV-TR to assess history of depressive disorders at baseline (lifetime history), postintervention, and 3-month follow-up...
October 11, 2016: Diabetes Care
Hamit Yasar Ellidag, Necat Yilmaz, Fatma Kurtulus, Ozgur Aydin, Esin Eren, Ayca Inci, Suleyman Dolu, Fatma Demet Arslan Ince, Özlem Giray, Aylin Yaman
BACKGROUND: The klotho (Klt)-fibroblast growth factor-23 (FGF-23)-vitamin D axis is the main component of calcium (Ca) and phosphorus (P) metabolisms; on the contrary, it is also secreted from the choroid plexus (CP). PURPOSE: This study is aimed at evaluating serum soluble Klt (sKlt), FGF-23, and 25-(OH)-vitamin D levels in multiple sclerosis (MS) patients. METHODS: Thirty-two relapsing-remitting MS patients (11 males and 21 females; mean age 38...
September 2016: Annals of Neurosciences
Maria Fleseriu, Mary E Bodach, Luis M Tumialan, Vivien Bonert, Nelson M Oyesiku, Chirag G Patil, Zachary Litvack, Manish K Aghi, Gabriel Zada
BACKGROUND: Nonfunctioning pituitary adenomas (NFPAs) are among the most common pituitary lesions and may present with hypopituitarism and/or hyperprolactinemia. OBJECTIVE: To review the existing literature as it pertains to preoperative endocrine assessment in the workup for NFPAs. METHODS: A systematic review methodology was utilized to identify and screen articles assessing the role and results of preoperative laboratory assessment in patients with NFPAs...
October 2016: Neurosurgery
B Paiva, N Puig, M T Cedena, B G de Jong, Y Ruiz, I Rapado, J Martinez-Lopez, L Cordon, D Alignani, J A Delgado, M C van Zelm, J J M Van Dongen, M Pascual, X Agirre, F Prosper, J I Martín-Subero, M-B Vidriales, N C Gutierrez, M T Hernandez, A Oriol, M A Echeveste, Y Gonzalez, S K Johnson, J Epstein, B Barlogie, G J Morgan, A Orfao, J Blade, M V Mateos, J J Lahuerta, J F San-Miguel
The notion that plasma cells (PCs) are terminally differentiated has prevented intensive research in multiple myeloma (MM) about their phenotypic plasticity and differentiation. Here, we demonstrated in healthy individuals (n=20) that the CD19-CD81 expression axis identifies three bone marrow (BM)PC subsets with distinct age-prevalence, proliferation, replication-history, immunoglobulin-production, and phenotype, consistent with progressively increased differentiation from CD19+CD81+ into CD19-CD81+ and CD19-CD81- BMPCs...
September 16, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Ma Etzabel Villegas-Rodríguez, Jaime Uribarri, Sergio E Solorio-Meza, Martha E Fajardo-Araujo, Weijing Cai, Sofía Torres-Graciano, Rubén Rangel-Salazar, Kazimierz Wrobel, Ma Eugenia Garay-Sevilla
AIM: The purpose of the study was the simultaneous measurement of all the different components of the AGE-RAGE axis as well as several non-invasive markers of cardiovascular disease (CVD) in a cohort of newly diagnosed diabetic patients. MATERIALS AND METHODS: In 80 newly diagnosed diabetic patients we measured serum carboxymethyllysine (CML), soluble RAGE (sRAGE) and peripheral mononuclear (PMNC) RAGE and AGER1 mRNA together with ICAM-1, VCAM-1, and malondialdehyde (MDA)...
2016: PloS One
R Ohrbach, S F Dworkin
This review explores the principles and process associated with the diagnosis of temporomandibular disorders (TMDs). TMD diagnosis has evolved substantially over the past 25 y. Previously, diagnosis focused solely on aberrations in oral structures, largely without empirical evidence. The Research Diagnostic Criteria for TMD (RDC/TMD) were developed on core principles of 1) a dual-axis system reflecting the biopsychosocial model, 2) a clear operationalization for reliability, and 3) the allowance of multiple diagnoses...
September 2016: Journal of Dental Research
Mara Carsote, Cristina Capatina, Ana Valea, Anda Dumitrascu
The male hypogonadism-related bone mass loss is often under diagnosed. Peak bone mass is severely affected if the hypogonadism occurs during puberty and is left untreated. We present an interesting; almost bizarre case of a male with non-functional testes early during childhood and undiagnosed and untreated hypogonadism until his fifth decade of life. Forty six year male is referred for goitre, complaining of back pain. Phenotype suggested intersexuality: gynoid proportions, micropenis, no palpable testes into the scrotum, no facial or truncal hair...
February 2016: Archives of Endocrinology and Metabolism
Neil F Goodman, Rhoda H Cobin, Walter Futterweit, Jennifer S Glueck, Richard S Legro, Enrico Carmina
Polycystic ovary syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This document, produced by the collaboration of the American Association of Clinical Endocrinologists and the Androgen Excess Society aims to highlight the most important clinical issues confronting physicians and their patients with PCOS. It is a summary of current best practices in 2014. Insulin resistance is believed to play an intrinsic role in the pathogenesis of PCOS. The mechanism by which insulin resistance or insulin give rise to oligomenorrhea and hyperandrogenemia, however, is unclear...
December 2015: Endocrine Practice
Cushla McKinney, Lisa K Stamp, Nicola Dalbeth, Ruth K Topless, Richard O Day, Diluk Rw Kannangara, Kenneth M Williams, Matthijs Janssen, Timothy L Jansen, Leo A Joosten, Timothy R Radstake, Philip L Riches, Anne-Kathrin Tausche, Frederic Lioté, Alexander So, Tony R Merriman
INTRODUCTION: The acute gout flare results from a localised self-limiting innate immune response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic individuals. Activation of the caspase recruitment domain-containing protein 8 (CARD8) NOD-like receptor pyrin-containing 3 (NLRP3) inflammasome by MSU crystals and production of mature interleukin-1β (IL-1β) is central to acute gouty arthritis. However very little is known about genetic control of the innate immune response involved in acute gouty arthritis...
2015: Arthritis Research & Therapy
Andrée-Anne Marchand, Jean-Alexandre Boucher, Julie O'Shaughnessy
OBJECTIVE: The purpose of this case report is to describe a patient who presented with acute musculoskeletal symptoms but was later diagnosed with multiple deep vein thrombosis (DVT). CLINICAL FEATURES: An 18-year-old female presented to a chiropractic clinic with left lumbosacral pain with referral into the posterior left thigh. A provisional diagnosis was made of acute myofascial syndrome of the left piriformis and gluteus medius muscles. The patient received 3 chiropractic treatments over 1 week resulting in 80% improvement in pain intensity...
June 2015: Journal of Chiropractic Medicine
Yanjie Li, Ning Li, Zhiling Yan, Hujun Li, Lili Chen, Zhiyao Zhang, Guoqin Fan, Kailin Xu, Zhenyu Li
OBJECTIVE: The NLRP3 inflammasome complex, an important regulatory factor of inflammation and cell apoptosis, has attracted considerable attention in the development of tumor. Here, we analyzed the expression and clinical significance of NLRP3 inflammasome complex and related cytokines in patients with multiple myeloma (MM). METHODS: Peripheral blood and bone marrow of 38 newly diagnosed myeloma patients and 25 age- and gender-matched healthy people were studied...
April 2016: Hematology (Amsterdam, Netherlands)
Jiangfeng Mao, Hongli Xu, Xi Wang, Bingkun Huang, Zhaoxiang Liu, Junjie Zhen, Min Nie, Le Min, Xueyan Wu
STUDY QUESTION: Do patients with congenital combined pituitary hormone deficiency (CCPHD) have different responses to gonadotrophin-induced spermatogenesis compared with those with idiopathic hypogonadotropic hypogonadism (IHH)? SUMMARY ANSWER: CCPHD patients have a better response to gonadotrophin therapy than IHH patients. WHAT IS KNOWN ALREADY: Gonadotrophins are effective in inducing spermatogenesis in patients with hypogonadotropic hypogonadism...
September 2015: Human Reproduction
Jerker Karlén, Johnny Ludvigsson, Max Hedmark, Åshild Faresjö, Elvar Theodorsson, Tomas Faresjö
BACKGROUND: Early psychosocial exposures are increasingly recognized as being crucial to health throughout life. A possible mechanism could be physiologic dysregulation due to stress. Cortisol in hair is a new biomarker assessing long-term hypothalamic-pituitary-adrenal axis activity. The objective was to investigate whether early-life adverse psychosocial circumstances influence infant cortisol levels in hair and health outcomes in children prospectively until age 10. METHODS: A cohort study in the general community using a questionnaire covering 11 psychosocial items in the family during pregnancy and the cumulative incidence of diagnoses until age 10 years in 1876 children...
June 2015: Pediatrics
Charles Jardin, Jafar Bakhshaie, Norman B Schmidt, Carla Sharp, Michael Zvolensky
BACKGROUND AND OBJECTIVES: Anxiety sensitivity is associated with smoking processes and poorer clinical outcomes. Yet, the specific mechanisms underlying this association are unclear. Smoking-specific avoidance and inflexibility (AIS) is a construct implicated in multiple manifestations of mood regulation that may underlie smoking severity. The current study examined whether AIS accounted for (ie, statistically mediated) the relationship between anxiety sensitivity and multiple indices of smoking severity...
June 2015: American Journal on Addictions
Marlene Hofmann, Barbara Halper, Stefan Oesen, Bernhard Franzke, Petra Stuparits, Harald Tschan, Norbert Bachl, Eva-Maria Strasser, Michael Quittan, Martin Ploder, Karl-Heinz Wagner, Barbara Wessner
There is a high need for blood-based biomarkers detecting age-related changes in muscular performance at an early stage. Therefore, we investigated whether serum levels of growth and differentiation factor-15 (GDF-15), activin A, myostatin, follistatin, and insulin-like growth factor-1 (IGF-1) would reflect age- and physical performance-related differences between young (22-28 years) and elderly (65-92 years) females. Isokinetic peak torque of knee extension (PTE) was measured in young females to obtain reference values for the discrimination of different stages of age-associated muscle weakness...
April 2015: Experimental Gerontology
Mehmet Mahir Atasoy, Nesrin Sariman, Ender Levent, Rahmi Çubuk, Ömer Çelik, Attila Saygi, Işil Atasoy, Sinan Şahin
PURPOSE: To retrospectively evaluate the prognostic parameters of computed tomography (CT) pulmonary angiographic findings in nonsevere (hemodynamically stable) pulmonary embolism (PE) patients and to assess the predictive value of these parameters for mortality within 1 month of the initial diagnosis. MATERIALS AND METHODS: Retrospectively, 67 consecutive patients (28 men, 39 women; mean age, 63.25 ± 18 years) from 2 centers with nonsevere PE diagnosed using CT and a clinical evaluation were included in the current study...
March 2015: Journal of Computer Assisted Tomography
Jennifer Mc Sharry, Felicity L Bishop, Rona Moss-Morris, Richard I G Holt, Tony Kendrick
BACKGROUND: Depression is two to three times more common in people with diabetes than in the general population. Although multimorbid diabetes and depression is associated with poor health outcome, existing research has focused on patients׳ understanding and management of each condition in isolation. This study describes the development and validation of the Diabetes and Depression Representation and Management Questionnaire (DDRMQ), a measure of understanding, management and medication beliefs in people with diabetes and depression...
March 15, 2015: Journal of Affective Disorders
Daniele Manfredini, Edoardo Stellini, Rosario Marchese-Ragona, Luca Guarda-Nardini
AIMS: The present study was designed to test the hypothesis that dental occlusion may have a role in mediating the effects of bruxism in temporomandibular disorders (TMD) patients. It aimed to answer the clinical research question: in a population of TMD patients with clinically diagnosed clenching-type bruxism, are the different TMD diagnoses associated with different occlusal features? MATERIALS AND METHODS: A total of 294 TMD patients (73% females, mean age 38·3±9·2 years) who were positive for a clinical diagnosis of clenching-type bruxism underwent an assessment in accordance with the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) axis I, as well as a recording of nine occlusal features...
October 2014: Cranio: the Journal of Craniomandibular Practice
Emmanuelle Tavernier, Carmen Aanei, Françoise Solly, Pascale Flandrin-Gresta, Lydia Campos, Denis Guyotat
CXCR4, receptor of the chemokine SDF-1 (stromal cell-derived factor 1) plays a major role in the normal hematopoiesis but also in the biology of the leukaemic cell. This receptor is expressed on the surface of blasts and is a key molecule in "the anchoring" of the leukaemic stem cell (LSC) within the bone marrow niche. The interactions of the LSC with the bone marrow microenvironment promote survival signals and drug resistance. Recent flow cytometry analyses reported that CXCR4 expression levels have a major prognostic impact in acute myeloid leukaemia (AML)...
June 2014: Bulletin du Cancer
Daniele Manfredini, Michele Vano, Redento Peretta, Luca Guarda-Nardini
OBJECTIVE: The aim of this investigation was to compare the pattern of temporomandibular disorder (TMD) diagnoses in clenching patients with different occlusal features, the null hypothesis being that no between-group differences exist. MATERIALS AND METHODS: Two groups of subjects receiving a jaw clenching diagnosis and having large overjet or anterior open bite (Group A; N=45, 75.5% females, mean age: 38.1 +/- 15.9 years) or normal occlusion (Group B; N=69, 71% females, mean age: 34...
January 2014: Cranio: the Journal of Craniomandibular Practice
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