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Erythropoiesis

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https://www.readbyqxmd.com/read/29785274/cross-sectional-assessment-of-achievement-of-therapeutic-goals-in-a-canadian-multidisciplinary-clinic-for-patients-with-advanced-chronic-kidney-disease
#1
Félix Rinfret, France Lambert, Joseph Tchetagni Youmbissi, Jean-François Arcand, Richard Turcot, Maral Alimardani Bessette, Solange Bourque, Vincent Moreau, Karine Tousignant, Diane Deschênes, Lyne Cloutier
Background: The implementation of advanced chronic kidney disease (CKD) multidisciplinary clinics has now demonstrated their effectiveness in delaying and even avoiding dialysis for patients with CKD. However, very little has been documented on the management and achievement of targets for a number of parameters in this context. Objective: Our goal was to assess our multidisciplinary clinic therapy performance in relation to the targets for hypertension, anemia, and calcium phosphate assessment...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29779328/-effect-of-sirolimus-on-erythropoiesis-of-k562-cell-line-and-patients-with-pure-red-cell-aplasia-in-vitro
#2
C Yang, F F Chen, Z B Long, Y L Du, H M Li, M Chen, B Han
Objective: To understand the effect of sirolimus on the erythropoiesis of K562 cell line and bone marrow cells from pure red cell aplasia (PRCA) patients and normal controls. Methods: Different concentrations (10, 100, 1 000 nmol/L) of sirolimus were added to the K562 cell line or bone marrow cells from PRCA patients or normal controls and cultured 14 days for BFU-E formation. Meanwhile, sirolimus was also added to the serum treated PRCA bone marrow cells to cultivate for the same priod of time. Results: Neither K562 cells, bone marrow cells from PRCA patients or normal controls showed any difference when sirolimus was added to the culture system for BFU-E...
April 14, 2018: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29777631/effect-of-deferasirox-erythropoietin-vs-erythropoietin-on-erythroid-response-in-low-int-1-risk-mds-patients-results-of-the-phase-ii-kallisto-trial
#3
Norbert Gattermann, Rosa Coll, Lutz Jacobasch, Allameddine Allameddine, Amin Azmon, Laurie DeBonnett, Andreas Bruederle, Jie Jin
OBJECTIVES: Erythropoiesis-stimulating agents (ESAs) remain first-choice to treat symptomatic anemia and delay transfusion dependence in most patients with lower-risk myelodysplastic syndromes (MDS) without del(5q). Deferasirox increased erythroid responses in some lower-risk MDS patients in clinical trials, and adding low-dose deferasirox to ESA treatment may further improve erythroid response. METHODS: KALLISTO (NCT01868477) was a randomized, open-label, multicenter, phase II study...
May 19, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29761390/isolation-and-phenotyping-of-bone-marrow-macrophages
#4
Marion Chalot
Macrophages are present in most of the tissues in the organism. They are basically separated into two categories: the resident macrophages, specific of the tissue and capable of proliferation, and the macrophages deriving from the monocyte differentiation. In the bone marrow, the "resident" macrophages are part of the hematopoietic stem cell niche.Those macrophages are known to have a role in the support of erythropoiesis (Chow, Nat Med 19:429-436, 2013), the maintenance of stem cell in their niches (Chow, J Exp Med 208:261-271, 2011), and are an independent self-renewing population (Hashimoto, Immunity 38:792-804, 2013)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29759803/reticulocyte-hemoglobin-content-mchr-in-the-assessment-of-iron-deficient-erythropoiesis-in-inflammatory-bowel-disease
#5
Eloísa Urrechaga, Johannes J M L Hoffmann, Antonio Bernal, Juan A Arévalo, José L Cabriada
BACKGROUND: In conditions associated with inflammation, biochemical parameters alone could be inadequate for assessing iron status. We investigated the potential utility of mean reticulocyte hemoglobin content (MCHr) in the assessment of the erythropoiesis status in inflammatory bowel disease (IBD). METHODS: We recruited 124 anemic outpatients with IBD. Serum iron, transferrin and ferritin were tested. Complete blood counts were performed on a CELL-DYN Sapphire analyzer (Abbott Diagnostics)...
April 22, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29755682/evaluation-of-the-impact-of-s-adenosylmethionine-dependent-methyltransferase-inhibitor-3-deazaneplanocin-a-on-tissue-injury-and-cognitive-function-in-mice
#6
Eva Lhuissier, Juliette Aury-Landas, Valentine Bouet, Céline Bazille, Yohann Repesse, Thomas Freret, Karim Boumédiene, Catherine Baugé
Cancer patients display cognitive impairment due, at least partly, to the treatments. Additionally, chemotherapeutic treatments can lead to organ injury, limiting their use, and are likely to have negative impacts on patients' quality of life. The aim of this study was to investigate the toxicity of 3-Deazaneplanocin A (DZNep) on several tissues and organs, as well as on cognitive functions. DZNep is an inhibitor of S-adenosylmethionine-dependent methyltransferase (in particular of the histone methyltransferase EZH2) which showed antitumoral functions in preclinical trials but whose effects on behavior and on organs (side effects) are not known...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29754961/hematopoietic-stem-cells-but-not-multipotent-progenitors-drive-erythropoiesis-during-chronic-erythroid-stress-in-epo-transgenic-mice
#7
Rashim Pal Singh, Tatyana Grinenko, Beáta Ramasz, Kristin Franke, Mathias Lesche, Andreas Dahl, Max Gassmann, Triantafyllos Chavakis, Ian Henry, Ben Wielockx
The hematopoietic stem cell (HSC) compartment consists of a small pool of cells capable of replenishing all blood cells. Although it is established that the hematopoietic system is assembled as a hierarchical organization under steady-state conditions, emerging evidence suggests that distinct differentiation pathways may exist in response to acute stress. However, it remains unclear how different hematopoietic stem and progenitor cell subpopulations behave under sustained chronic stress. Here, by using adult transgenic mice overexpressing erythropoietin (EPO; Tg6) and a combination of in vivo, in vitro, and deep-sequencing approaches, we found that HSCs respond differentially to chronic erythroid stress compared with their closely related multipotent progenitors (MPPs)...
May 4, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29753742/mirna-152-targets-gata1-to-regulate-erythropoiesis-in-chionodraco-hamatus
#8
Jiulin Chan, Xingxing Hu, Congcong Wang, Qianghua Xu
Chionodraco hamatus is a teleost within the suborder Notothenioidei, the members of which are known to lack functional erythrocytes with modified hematopoiesis. Hematopoiesis is an essential process during the development of animals, where it is tightly regulated by many different transcription factors, signaling proteins, chromatin modifications, and microRNAs (miRNAs). The miRNAs are known to regulate the expression of their target genes at the post-transcriptional level. However, little is known about the miRNA-mediated regulation of hematopoiesis...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29746307/erythropoietin-mimetic-peptides-and-erythropoietin-fusion-proteins-for-treating-anemia-of-chronic-kidney-disease
#9
Nupur Gupta, Jay B Wish
PURPOSE OF REVIEW: First generation erythropoiesis stimulating agents (ESAs) have short duration of action which requires administration once weekly or greater. Second generation ESAs were developed which have longer duration of action and can be administered one to two times monthly. Erythropoietin (EPO) mimetic peptides (EMPs) activate the EPO receptor but have no structural analogy to EPO, offering the potential for lower cost as they are not biologic drugs. The first approved EMP, peginesatide, was withdrawn from the market within a year of its approval because of fatal anaphylactic reactions...
May 4, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29746238/methods-for-studying-iron-regulatory-protein-1-an-important-protein-in-human-iron-metabolism
#10
Gregory P Holmes-Hampton, Manik C Ghosh, Tracey A Rouault
Iron regulatory proteins 1 and 2 (IRP1 and IRP2) are two cytosolic proteins that maintain cellular iron homeostasis by regulating the expression of genes involved in iron metabolism. IRPs respond to cellular iron deficiency by binding to iron-responsive elements (IREs) found in the mRNAs of iron metabolism transcripts, enhancing iron import, and reducing iron storage, utilization, and export. IRP1, a bifunctional protein, exists in equilibrium between a [Fe4 S4 ] cluster containing cytosolic aconitase, and an apoprotein that binds to IREs...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29744352/limitations-of-serum-ferritin-in-diagnosing-iron-deficiency-in-inflammatory-conditions
#11
REVIEW
Axel Dignass, Karima Farrag, Jürgen Stein
Patients with inflammatory conditions such as inflammatory bowel disease (IBD), chronic heart failure (CHF), and chronic kidney disease (CKD) have high rates of iron deficiency with adverse clinical consequences. Under normal circumstances, serum ferritin levels are a sensitive marker for iron status but ferritin is an acute-phase reactant that becomes elevated in response to inflammation, complicating the diagnosis. Proinflammatory cytokines also trigger an increase in hepcidin, which restricts uptake of dietary iron and promotes sequestration of iron by ferritin within storage sites...
2018: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29742267/epoetin-alfa-resistance-in-hemodialysis-patients-with-chronic-kidney-disease-a-longitudinal-study
#12
E J F Santos, E V Hortegal, H O Serra, J S Lages, N Salgado-Filho, A M Dos Santos
Anemia is an inevitable complication of hemodialysis, and the primary cause is erythropoietin deficiency. After diagnosis, treatment begins with an erythropoiesis-stimulating agent (ESA). However, some patients remain anemic even after receiving this medication. This study aimed to investigate the factors associated with resistance to recombinant human erythropoietin therapy with epoetin alfa (αEPO). We performed a prospective, longitudinal study of hemodialysis patients receiving treatment with αEPO at our reference hospital from July 2015 to June 2016...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29741776/skewed-megakaryopoiesis-in-human-induced-pluripotent-stem-cell-derived-haematopoietic-progenitor-cells-harbouring-calreticulin-mutations
#13
Hiraku Takei, Yoko Edahiro, Shuichi Mano, Nami Masubuchi, Yoshihisa Mizukami, Misa Imai, Soji Morishita, Kyohei Misawa, Tomonori Ochiai, Satoshi Tsuneda, Hiroshi Endo, Sou Nakamura, Koji Eto, Akimichi Ohsaka, Marito Araki, Norio Komatsu
Somatic mutations in the calreticulin (CALR) gene have been found in most patients with JAK2- and MPL-unmutated Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). It has recently been shown that mutant CALR constitutively activates the thrombopoietin receptor MPL and, thus, plays a causal role in the development of MPNs. However, the roles of mutant CALR in human haematopoietic cell differentiation remain predominantly elusive. To examine the impact of the 5-base insertion mutant CALR gene (Ins5) on haematopoietic cell differentiation, we generated induced pluripotent stem cells from an essential thrombocythaemia (ET) patient harbouring a CALR-Ins5 mutation and from a healthy individual (WT)...
May 9, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29741264/genetic-basis-of-congenital-erythrocytosis
#14
REVIEW
C Bento
INTRODUCTION: Congenital Erythrocytosis (CE) represents a rare and heterogeneous clinical entity. It is caused by deregulated erythropoiesis where red blood cell overproduction results in elevated hemoglobin and hematocrit levels. CE may either be primary or secondary to elevated erythropoietin concentrations. The only known form of primary CE is caused by mutations in the EPOR gene. Secondary CE can be a consequence of tissue hypoxia, being caused by congenital defects such as hemoglobin variants with increased oxygen affinity, due to mutations in the α- or β-globin genes (HBB, HBA2, HBA1), or due to mutations in the BPGM gene...
May 2018: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29739485/inhibition-of-ex-vivo-erythropoiesis-by-secreted-and-haemozoin-associated-plasmodium-falciparum-products
#15
Daniela Boehm, Lydia Healy, Sarah Ring, Angus Bell
It has been estimated that up to a third of global malaria deaths may be attributable to malarial anaemia, with children and pregnant women being those most severely affected. An inefficient erythropoietic response to the destruction of both infected and uninfected erythrocytes in infections with Plasmodium spp. contributes significantly to the development and persistence of such anaemia. The underlying mechanisms, which could involve both direct inhibition of erythropoiesis by parasite-derived factors and indirect inhibition as a result of modulation of the immune response, remain poorly understood...
May 9, 2018: Parasitology
https://www.readbyqxmd.com/read/29736258/mtf2-prc2-control-of-canonical-wnt-signaling-is-required-for-definitive-erythropoiesis
#16
Janet L Manias Rothberg, Harinad B Maganti, Hani Jrade, Christopher J Porter, Gareth A Palidwor, Christopher Cafariello, Hannah L Battaion, Safwat T Khan, Theodore J Perkins, Robert F Paulson, Caryn Y Ito, William L Stanford
Polycomb repressive complex 2 (PRC2) accessory proteins play substoichiometric, tissue-specific roles to recruit PRC2 to specific genomic loci or increase enzymatic activity, while PRC2 core proteins are required for complex stability and global levels of trimethylation of histone 3 at lysine 27 (H3K27me3). Here, we demonstrate a role for the classical PRC2 accessory protein Mtf2/Pcl2 in the hematopoietic system that is more akin to that of a core PRC2 protein. Mtf2 -/- erythroid progenitors demonstrate markedly decreased core PRC2 protein levels and a global loss of H3K27me3 at promoter-proximal regions...
2018: Cell Discovery
https://www.readbyqxmd.com/read/29732532/pathogenesis-diagnosis-and-treatment-of-anaemia-in-immune-mediated-gastrointestinal-disorders
#17
REVIEW
Gaetano Bergamaschi, Antonio Di Sabatino, Gino R Corazza
Immune-mediated disorders affecting the gastrointestinal (GI) tract may compromise GI integrity, interfere with the absorption of nutrients and cause bleeding and inflammation. All these features contribute to the pathogenesis of anaemia, the most prevalent extra-intestinal manifestation of immune-mediated GI disorders. Anaemia is most commonly due to iron deficiency and/or inflammation, but vitamin deficiencies and, more infrequently, autoimmune haemolysis or drug-induced myelosuppression can be involved. Here we address several issues related to the differential diagnosis and treatment of anaemia in immune-mediated GI disorders, giving particular relevance to the problem of iron deficiency anaemia associated with inflammation...
May 6, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29729498/pressure-shock-triploidization-of-salmo-trutta-f-lacustris-and-salvelinus-umbla-eggs-and-its-impact-on-fish-development
#18
Franz Lahnsteiner, Manfred Kletzl
The study tested the efficiency of hydrostatic pressure triploidization methods for Salmo trutta f. lacustris and Salvelinus umbla and investigated the effects on survival rate, skeletal malformation, and on morphometrics and cellular composition of gills, spleen, liver, kidney, intestine, and blood. In Salmo trutta f. lacustris a 100% triploidy rate in combination with high larvae survival rate (80% in comparison to control) was obtained when treating eggs with a pressure of 66 × 103  kPa 360 °C temperature minutes (CTM) post fertilization for 5 min, in Salvelinus umbla with a similar pressure after 270 CTM...
April 24, 2018: Theriogenology
https://www.readbyqxmd.com/read/29728407/non-specific-inhibition-of-erythropoiesis-by-short-hairpin-rnas
#19
Elizabeth A Traxler, Christopher S Thom, Yu Yao, Vikram Paralkar, Mitchell J Weiss
No abstract text is available yet for this article.
May 4, 2018: Blood
https://www.readbyqxmd.com/read/29725593/phosphorylated-forms-of-stat1-stat3-and-stat5-are-expressed-in-proliferating-but-not-involuted-infantile-hemangioma
#20
Lucy Sulzberger, Elysia M S Tan, Paul F Davis, Helen D Brasch, Swee T Tan, Tinte Itinteang
We have recently demonstrated the expression of embryonic stem cell markers on the endothelium of infantile hemangioma, a functional hemogenic endothelium with the capacity for primitive erythropoiesis in vitro . Despite recent work characterizing stem cells within proliferating infantile hemangioma, the expression of STAT proteins, well documented for their roles in stem cell signaling, has not been investigated. 3,3-Diaminobenzidine and immunofluorescence immunohistochemical staining revealed expression of pSTAT1, pSTAT3 and pSTAT5 in proliferating infantile hemangioma samples with the strongest expression of pSTAT3...
2018: Frontiers in Surgery
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