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https://www.readbyqxmd.com/read/28822353/vdr-gene-variation-and-insulin-resistance-related-diseases
#1
Fei-Fei Han, Ya-Li Lv, Li-Li Gong, He Liu, Zi-Rui Wan, Li-Hong Liu
BACKGROUND: Vitamin D status may influence the risk of Insulin resistance related diseases such as Type 2 diabetes (T2DM), metabolic syndrome (MetS), and polycystic ovarian syndrome (PCOS). Several studies have assessed vitamin D receptor (VDR) gene polymorphism in relationship with these diseases; however, results remain inconsistent. Our study was conducted to elucidate whether VDR Gene polymorphisms could predict insulin resistance on a large scale. METHODS: A meta-analysis using MEDLINE and EMBASE, was performed up to December 16th, 2016...
August 19, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28817668/titanium-biomaterials-with-complex-surfaces-induced-aberrant-peripheral-circadian-rhythms-in-bone-marrow-mesenchymal-stromal-cells
#2
Nathaniel Hassan, Kirstin McCarville, Kenzo Morinaga, Cristiane M Mengatto, Peter Langfelder, Akishige Hokugo, Yu Tahara, Christopher S Colwell, Ichiro Nishimura
Circadian rhythms maintain a high level of homeostasis through internal feed-forward and -backward regulation by core molecules. In this study, we report the highly unusual peripheral circadian rhythm of bone marrow mesenchymal stromal cells (BMSCs) induced by titanium-based biomaterials with complex surface modifications (Ti biomaterial) commonly used for dental and orthopedic implants. When cultured on Ti biomaterials, human BMSCs suppressed circadian PER1 expression patterns, while NPAS2 was uniquely upregulated...
2017: PloS One
https://www.readbyqxmd.com/read/28817541/titers-of-antibodies-to-the-surface-antigen-of-hepatitis-b-virus-after-vaccination-in-relation-to-immunity-related-gene-variants-a-prospective-study-among-hemodialysis-patients
#3
Elżbieta Jodłowska-Siewert, Paweł P Jagodziński, Alicja E Grzegorzewska
INTRODUCTION    Hemodialysis (HD) patients show a weaker response to hepatitis B virus (HBV) vaccination than the healthy population. Several gene variants were reported to be associated with the levels of antibodies to HBV surface antigen (anti-HBs) after HBV vaccination among healthy individuals. OBJECTIVES    The aim of the study was to determine the effect of immunity-related genes on the maximum anti-HBs antibody levels after vaccination among HD subjects. PATIENTS AND METHODS    This 6-year prospective study included HD patients who were not infected with HBV and underwent HBV vaccination...
August 9, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28816551/1%C3%AE-25-dihydroxyvitamin-d3-up-regulates-il-34-expression-in-sh-sy5y-neural-cells
#4
Dong Zhang, Miaomiao Li, Yang Dong, Xinhui Zhang, Xingyun Liu, Zhangming Chen, Yongji Zhu, Huiming Wang, Xuwen Liu, Jialiang Zhu, Yujun Shen, Heinrich Korner, Songcheng Ying, Shengyun Fang, Yuxian Shen
Vitamin D supplementation is regarded as a novel approach to treat Alzheimer's disease, but the underlying mechanism remains elusive. The cytokine IL-34 provides strong neuroprotective and survival signals in brain injury and neurodegeneration and could be an immunological mediator for the vitamin D-induced protection. The aim of this study was to investigate whether human IL-34 is up-regulated in neuronal cells by the hormonally active form of vitamin D, 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. We found that IL-34 was detectable in a variety of cell lines and its expression was strongly induced in SH-SY5Y neural cells in a dose- and time-dependent manner by 1α,25(OH)2D3 through the vitamin D receptor (VDR)...
January 1, 2017: Innate Immunity
https://www.readbyqxmd.com/read/28814738/identification-of-novel-non-secosteroidal-vitamin-d-receptor-agonists-with-potent-cardioprotective-effects-and%C3%A2-%C3%AF-%C3%AF-devoid-of-hypercalcemia
#5
Santosh A Khedkar, Mohammed A Samad, Sangita Choudhury, Ji Yoo Lee, Dongsheng Zhang, Ravi I Thadhani, S Ananth Karumanchi, Alan C Rigby, Peter M Kang
Vitamin D regulates many biological processes, but its clinical utility is limited by its hypercalcemic effect. Using a virtual screening platform to search novel chemical probes that activate the vitamin D signaling, we report discovery of novel non-steroidal small-molecule compounds that activate the vitamin D receptor (VDR), but are devoid of hypercalcemia. A lead compound (known as VDR 4-1) demonstrated potent transcriptional activities in a VDR reporter gene assay, and significantly ameliorated cardiac hypertrophy in cell culture studies and in animal models...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811844/lsd1-dual-function-in-mediating-epigenetic-corruption-of-the-vitamin-d-signaling-in-prostate-cancer
#6
Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T Moser, Dominic J Smiraglia, Barbara A Foster
BACKGROUND: Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D) action in prostate cancer (PCa). METHODS: Athymic nude mice were xenografted with CWR22 cells and monitored weekly after testosterone pellet removal. Expression of LSD1 and VDR (IHC) were correlated with tumor growth using log-rank test...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28811597/vitamin-d-receptor-gene-polymorphisms-modify-cardiometabolic-response-to-vitamin-d-supplementation-in-t2dm-patients
#7
Nasser M Al-Daghri, Abdul Khader Mohammed, Omar S Al-Attas, Mohammed Ghouse Ahmed Ansari, Kaiser Wani, Syed D Hussain, Shaun Sabico, Gyanendra Tripathi, Majed S Alokail
There is conflicting evidence on the favorable effects of vitamin D supplementation on metabolic profile in Type 2 diabetes mellitus (T2DM) patients and this might be due to genetic variations in vitamin D receptors (VDRs). Thus, we studied the metabolic effects of a 12-month vitamin D supplementation in T2DM patients according to VDR polymorphisms. A total of 204 T2DM subjects received 2000 IU vitamin D3 daily for 12 months. Serum 25(OH)D and metabolic profiles were measured at baseline and after 12 months...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808890/vitamin-d-activity-and-metabolism-in-bone
#8
REVIEW
Paul H Anderson
PURPOSE OF REVIEW: In addition to the actions of the endocrine hormone, 1alpha,25-dihydroxyvitamin D (1,25(OH)2D) in stimulating intestinal calcium absorption, the regulation of bone mineral metabolism by 1,25(OH)2D is also considered an important contributor to calcium homeostasis. However, recent evidence suggest that 1,25(OH)2D acting either via endocrine or autocrine pathways plays varied roles in bone, which suggests that vitamin D contributes to the maintenance of bone mineral in addition to its catabolic roles...
August 14, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28806841/genetic-polymorphisms-as-predictive-markers-of-response-to-growth-hormone-therapy-in-children-with-growth-hormone-deficiency
#9
Anna Maria Jung, Martin Zenker, Christina Lißewski, Denny Schanze, Stefan Wagenpfeil, Tilman Robert Rohrer
Objective Growth hormone (GH) deficiency (GHD) is commonly treated with recombinant human GH (rhGH). Individual response to rhGH therapy varies widely and there is evidence that variations in growth-related genes, e. g. the GH receptor (GHR) gene, may impact treatment response. We aimed to identify genetic polymorphisms which could serve as predictive markers of response to rhGH therapy. Methods We conducted a genetic analysis of single nucleotide polymorphisms (SNPs) and the GHR exon 3 deletion in 101 paediatric GHD patients receiving rhGH...
August 14, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/28806534/knockdown-of-snail-inhibits-epithelial-mesenchymal-transition-of-human-laryngeal-squamous-cell-carcinoma-hep-2-cells-through-vdr-signaling-pathway
#10
Xue Zhao, Dan Yu, Jingpu Yang, Kai Xue, Yan Liu, Chunshun Jin
It has been well-documented that Snail plays a decisive role in various tumors. However, the direct effect of Snail on laryngeal squamous cell carcinoma (LSCC) has not been elaborated. In this study, we firstly detected the expression of Snail in 14 samples of patients with LSCC and found that its content was high in cancer tissues compared with adjacent tissues. Then we established LSCC Hep-2 cells with Snail silencing and validated the knockdown efficiency by western blotting and real-time PCR. Results showed that silencing of Snail significantly inhibited the ability of adhesion, migration, and invasion of Hep-2 cells...
August 14, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28803336/transgenic-mice-overexpressing-vitamin-d-receptor-vdr-show-anti-inflammatory-effects-in-lung-tissues
#11
Masaki Ishii, Yasuhiro Yamaguchi, Kyoko Isumi, Sumito Ogawa, Masahiro Akishita
Vitamin D insufficiency is increasingly recognized as a prevalent problem worldwide, especially in patients with a chronic lung disease. Chronic obstructive pulmonary disease (COPD) is a type of chronic inflammatory lung disease. Previous clinical studies have shown that COPD leads to low vitamin D levels, which further increase the severity of COPD. Vitamin D homeostasis represents one of the most important factors that potentially determine the severity of COPD. Nonetheless, the mechanisms underlying the anti-inflammatory effects of vitamin D receptor (VDR) in lung tissues are still unclear...
August 12, 2017: Inflammation
https://www.readbyqxmd.com/read/28799838/vitamin-d-receptor-gene-foki-polymorphism-in-egyptian-children-and-adolescents-with-sle-a-case-control-study
#12
A A Imam, H E Ibrahim, M A A Farghaly, U M Alkholy, H H Gawish, N Abdalmonem, A M Sherif, Y F Ali, M E Hamed, N M Waked, M M Fathy, A M Khalil, M A Noah, M S Hegab, B R Ibrahim, R M Nabil, L A Fattah
Background Childhood-onset systemic lupus erythematosus (cSLE) is a lifelong autoimmune disorder. The vitamin D receptor (VDR) gene is a potential candidate gene for cSLE susceptibility. In this study, we aimed to investigate the FokI polymorphism in the VDR gene in Egyptian children and adolescents with SLE, to determine whether this polymorphism could be a genetic marker for cSLE susceptibility or disease activity and we also measured the serum level of 25-hydroxyvitamin D [25(OH) D] to assess its relation to such polymorphism...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28797922/vitamin-d-receptor-expression-and-potential-role-of-vitamin-d-on-cell-proliferation-and-steroidogenesis-in-goat-ovarian-granulosa-cells
#13
Xiaolei Yao, Guomin Zhang, Yixuan Guo, Mohamed Ei-Samahy, Shuting Wang, Yongjie Wan, Le Han, Zifei Liu, Feng Wang, Yanli Zhang
This study aimed to investigate the expression of the vitamin D receptor (VDR) in goat follicles and to determine the effects of Vit D3 supplementation on goat granulosa cells (GCs) function linked to follicular development. The results demonstrated that VDR was prominently localized in GCs, with expression increasing with follicle diameter. Addition of Vit D3 (1α,25-(OH)2VD3; 10 nM) to GCs caused an increase in VDR and in steroidogenic acute regulator (StAR) and 3β-hydroxysteroid dehydrogenase (3β-HSD) mRNA expression...
August 3, 2017: Theriogenology
https://www.readbyqxmd.com/read/28794851/expression-of-jazf1-abcc8-kcnj11and-notch2-genes-and-vitamin-d-receptor-polymorphisms-in-type-2-diabetes-and-their-association-with-microvascular-complications
#14
Maha A Rasheed, Nagwa Kantoush, Nagwa Abd El-Ghaffar, Hebatallah Farouk, Solaf Kamel, Alshaymaa Ahmed Ibrahim, Aliaa Shalaby, Eman Mahmoud, Hala M Raslan, Omneya M Saleh
BACKGROUND: We studied JAZF1, ABCC8, KCNJ11and Notch2 gene expression and vitamin D receptor (VDR) polymorphisms (Fok1 and Bsm1) in patients with type 2 diabetes mellitus (T2DM) and tried to find out their association with microvascular complications in these patients. METHODS: The study was conducted on 180 patients (93 complicated and 87 noncomplicated) and 150 healthy subjects. Reverse-transcriptase polymerase chain reaction (RT-PCR) was used to assess gene expression and real-time PCR was used to detect VDR genotypes...
June 2017: Therapeutic Advances in Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28790326/intestinal-toxicity-of-the-type-b-trichothecene-mycotoxin-fusarenon-x-whole-transcriptome-profiling-reveals-new-signaling-pathways
#15
Imourana Alassane-Kpembi, Juliana Rubira Gerez, Anne-Marie Cossalter, Manon Neves, Joëlle Laffitte, Claire Naylies, Yannick Lippi, Martine Kolf-Clauw, Ana Paula L Bracarense, Philippe Pinton, Isabelle P Oswald
The few data available on fusarenon-X (FX) do not support the derivation of health-based guidance values, although preliminary results suggest higher toxicity than other regulated trichothecenes. Using histo-morphological analysis and whole transcriptome profiling, this study was designed to obtain a global view of the intestinal alterations induced by FX. Deoxynivalenol (DON) served as a benchmark. FX induced more severe histological alterations than DON. Inflammation was the hallmark of the molecular toxicity of both mycotoxins...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28780723/vitamin-d-receptor-gene-polymorphism-association-with-susceptibility-to-early-onset-breast-cancer-in-iranian-brca1-2-mutation-carrier-and-non-carrier-patients
#16
Ahmad Shahabi, Majid Alipour, Hamid Safiri, Parsa Tavakol, Mehdi Alizadeh, S Milad Hashemi, Mahdieh Shahabi, Mohammad Halimi
Mounting evidences support that vitamin D insufficiency or deficiency is a risk factor of breast cancer. Vitamin D receptor (VDR) is expressed in more than 36 cell types in different organs as in cancerous cells. Numerous allelic variants of VDR gene have been identified in human populations. Association of FokI (rs2228570) and BsmI (rs1544410) single nucleotide polymorphisms (SNPs) in VDR gene with the risk of breast cancer have been investigated in several studies, however, the published data are still inconsistent...
August 6, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28780323/vitamin-d-receptor-gene-polymorphisms-and-the-risk-of-multiple-sclerosis-an-updated-meta-analysis
#17
Xiao-Long Chen, Ming-Liang Zhang, Lin Zhu, Meng-Le Peng, Fang-Zhou Liu, Guang-Xian Zhang, Li-Mei Wang, Jie Zhao
BACKGROUND: The association between vitamin D receptor (VDR) gene polymorphisms and multiple sclerosis (MS) has been extensively studied, but results were controversial. METHODS: This meta-analysis aimed to confirm whether VDR gene polymorphisms were associated with MS. Meta-analysis on the association between MS and VDR ApaI, BsmI, TaqI and FokI polymorphisms were conducted using allelic contrast, recessive, homozygotes and dominant models. Data were extracted by standardized forms and odds ratios (OR) with 95% confidence intervals (CI) were calculated using the random effects model if the results were heterogeneous...
August 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28778077/interactions-between-vitamin-d-receptor-vdr-gene-and-interleukin-6%C3%A2-gene-and-environment-factors-on-coronary-heart-disease-risk-in-a-chinese-han-population
#18
Ma Jun, Guan Xue-Qiang, Li Jia, Xue Yang-Jing, Zheng Cheng, Jin Ge
AIMS: To investigate the association of several single nucleotide polymorphisms (SNPs) within Interleukin-6 (IL- 6) and vitamin D receptor (VDR) gene, and additional gene- gene and gene- smoking interaction with coronary heart disease (CHD) risk in a Chinese population. METHODS: Hardy-Weinberg equilibrium (HWE) examination was used by SNPstats (http://bioinfo.iconcologia.net/SNPstats). Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among SNPs and smoking...
July 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28778065/1-25d3-differentially-suppresses-bladder-cancer-cell-migration-and-invasion-through-the-induction-of-mir-101-3p
#19
Yingyu Ma, Wei Luo, Brittany L Bunch, Rachel N Pratt, Donald L Trump, Candace S Johnson
Metastasis is the major cause of bladder cancer death. 1,25D3, the active metabolite of vitamin D, has shown anti-metastasis activity in several cancer model systems. However, the role of 1,25D3 in migration and invasion in bladder cancer is unknown. To investigate whether 1,25D3 affects migration and invasion, four human bladder cell lines with different reported invasiveness were selected: low-invasive T24 and 253J cells and highly invasive 253J-BV and TCCSUP cells. All of the four bladder cancer cells express endogenous and inducible vitamin D receptor (VDR) as examined by immunoblot analysis...
July 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28774952/vitamin-d-supplementation-of-initially-vitamin-d-deficient-mice-diminishes-lung-inflammation-with-limited-effects-on-pulmonary-epithelial-integrity
#20
Shelley Gorman, Alysia G Buckley, Kak-Ming Ling, Luke J Berry, Vanessa S Fear, Stephen M Stick, Alexander N Larcombe, Anthony Kicic, Prue H Hart
In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. Female BALB/c dams were fed a vitamin D3-supplemented (2280 IU/kg, VitD(+)) or nonsupplemented (0 IU/kg, VitD(-)) diet from 3 weeks of age, and mated at 8 weeks of age. Male offspring were fed the same diet as their mother. Some offspring initially fed the VitD(-) diet were switched to a VitD(+) diet from 8 weeks of age (VitD(-/+))...
August 2017: Physiological Reports
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