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https://www.readbyqxmd.com/read/29684480/fetuin-b-links-vitamin-d-deficiency-and-pediatric-obesity-direct-negative-regulation-by-vitamin-d
#1
Gillian E Walker, Antonia Follenzi, Valentina Bruscaggin, Marcello Manfredi, Simonetta Bellone, Emilio Marengo, Luigi Maiuri, Flavia Prodam, Gianni Bona
Vitamin D (VD) deficiency (VDD) correlates to obesity, with VD a recognized mediator of metabolic diseases. From a previous proteomic study identifying adiponectin as a link between VDD and pediatric obesity, herein we analysed another protein (SSP2301) increased with VDD. A focused 2D-electrophoretic analysis identified 4 corresponding plasma proteins, with one predicted to be fetuin B (FETUB). FETUB was studied due to its emerging role in metabolic diseases and cytogenetic location (3q27.3) with adiponectin...
April 20, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29684027/chronic-calcitriol-supplementation-improves-the-inflammatory-profiles-of-circulating-monocytes-and-the-associated-intestinal-adipose-tissue-alteration-in-a-diet-induced-steatohepatitis-rat-model
#2
Yen-Bo Su, Tzu-Hao Li, Chia-Chang Huang, Hung-Cheng Tsai, Shiang-Fen Huang, Yun-Cheng Hsieh, Ying-Ying Yang, Yi-Hsiang Huang, Ming-Chih Hou, Han-Chieh Lin
Vitamin D deficiency and up-regulated TNFα-related signals are reported to be involved in abnormalities including intestinal hyper-permeability, bacterial translocation, systemic/portal endotoxemia, intestinal/adipose tissue/hepatic inflammation, and hepatic steatosis in nonalcoholic steatohepatitis (NASH). This study aims to explore the molecular mechanisms and effects of chronic calcitriol [1,25-(OH)2D3, hormonal form of vitamin D] on gut-adipose tissue-liver axis abnormalities using a high-fat diet (HFD)-fed rat model of NASH...
2018: PloS One
https://www.readbyqxmd.com/read/29669566/apa-i-polymorphism-in-vdr-gene-is-related-to-metabolic-syndrome-in-polycystic-ovary-syndrome-a-cross-sectional-study
#3
Betânia Rodrigues Santos, Sheila Bunecker Lecke, Poli Mara Spritzer
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder determined by polygenic traits as well as environmental factors. Lower vitamin D levels have been detected in PCOS women and related to hormone and metabolic disturbances. Vitamin D acts in tissues through the vitamin D receptor (VDR). VDR gene variants have been associated with worse metabolic profile in the general population. We investigated the genotype and haplotype distribution of the Bsm-I (rs1544410), Apa-I (rs7975232), and Taq-I (rs731236) VDR gene polymorphisms in PCOS and non-hirsute women from southern Brazil...
April 18, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29668990/vitamin-d-receptor-activation-raises-soluble-thrombomodulin-levels-in-chronic-kidney-disease-patients-a-double-blind-randomized-trial
#4
Graziella D'arrigo, Patrizia Pizzini, Sebastiano Cutrupi, Rocco Tripepi, Giovanni Tripepi, Francesca Mallamaci, Carmine Zoccali
Background: Thrombomodulin (TM) is a proteoglycan highly represented in the endothelial glycocalix that regulates the haemostasis and the endothelial response to inflammation. High soluble TM levels underlie a lower risk for coronary heart disease in population studies. Activation of vitamin D receptor (VDR) upregulates TM, but the effect of this intervention on soluble TM has never been tested in chronic kidney disease (CKD) patients. Methods: We performed a post hoc analysis of a 12 weeks double blind, randomized, placebo-controlled trial testing the effect of VDR activation by paricalcitol (PCT) on endothelium-dependent flow-mediated vasodilatation (FMD) in the forearm (ClinicalTrials...
April 13, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29659895/identification-of-differential-transcriptional-patterns-in-primary-and-secondary-hyperparathyroidism
#5
Samira M Sadowski, Marc Pusztaszeri, Marie-Claude Brulhart-Meynet, Volodymyr Petrenko, Claudio De Vito, Jonathan Sobel, Céline Delucinge-Vivier, Electron Kebebew, Romano Regazzi, Jacques Philippe, Frédéric Triponez, Charna Dibner
Context: Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion. However, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PG) in sporadic primary and secondary hyperparathyroidism (HPT1, 2). Objective: To evaluate dynamic alterations in molecular patterns as a function of the type of PG pathology, a comparative transcript analysis was conducted in subgroups of healthy samples, sporadic HPT1 adenoma and hyperplasia, and HPT2...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29659618/vitamin-d-receptor-suppresses-proliferation-and-metastasis-in-renal-cell-carcinoma-cell-lines-via-regulating-the-expression-of-the-epithelial-ca2-channel-trpv5
#6
YongMing Chen, XinYu Liu, FaBiao Zhang, ShanFan Liao, XiYuan He, DeXiang Zhuo, HuaiBin Huang, YongYang Wu
We previously demonstrated that transient receptor potential vanilloid subfamily 5 (TRPV5) expression was decreased in renal cell carcinoma (RCC) compared with that in normal kidney tissues, a finding that was correlated with vitamin D receptor (VDR) expression, but further investigations is warranted. The aim of this study was to elucidate whether VDR could regulate the expression of TRPV5 and affect proliferation and metastasis in RCC. In this study, we used lentivirus to conduct the model of VDR overexpression and knockdown caki-1 and 786-O RCC cell lines in vitro...
2018: PloS One
https://www.readbyqxmd.com/read/29657326/exploring-vitamin-d-metabolism-and-function-in-cancer
#7
REVIEW
Sang-Min Jeon, Eun-Ae Shin
Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid hormone that regulates a broad spectrum of physiological processes. In addition to its classical roles in bone metabolism, epidemiological, preclinical, and cellular research during the last decades, it revealed that vitamin D may play a key role in the prevention and treatment of many extra-skeletal diseases such as cancer. Vitamin D, as a prohormone, undergoes two-step metabolism in liver and kidney to produce a biologically active metabolite, calcitriol, which binds to the vitamin D receptor (VDR) for the regulation of expression of diverse genes...
April 16, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29652161/synthesis-of-side-chain-locked-analogs-of-1%C3%AE-25-dihydroxyvitamin-d-3-bearing-a-c17-methyl-group
#8
Rita Sigüeiro, Miguel A Maestro, Antonio Mouriño
A convergent synthesis of side-chain locked vitamin D analogs 3 and 4, which bind strongly in silico to the vitamin D receptor (VDR), is described. The synthetic approach features an SN 2'- syn displacement of carbamates by cuprates to set the challenging quaternary stereogenic center at C17 and a Pd-catalyzed construction of the triene system in the presence of a diyne moiety.
April 13, 2018: Organic Letters
https://www.readbyqxmd.com/read/29629442/assessment-of-endocrine-disruption-potential-of-essential-oils-of-culinary-herbs-and-spices-involving-glucocorticoid-androgen-and-vitamin-d-receptors
#9
Iveta Bartoňková, Zdeněk Dvořák
Essential oils (EOs) of culinary herbs and spices are consumed on a daily basis. They are multicomponent mixtures of compounds with already demonstrated biological activities. Taking into account regular dietary intake and the chemical composition of EOs, they may be considered as candidates for endocrine-disrupting entities. Therefore, we examined the effects of 31 EOs of culinary herbs and spices on transcriptional activities of glucocorticoid receptor (GR), androgen receptor (AR) and vitamin D receptor (VDR)...
April 9, 2018: Food & Function
https://www.readbyqxmd.com/read/29628342/meg3-activated-by-vitamin-d-inhibits-colorectal-cancer-cells-proliferation-and-migration-via-regulating-clusterin
#10
Yan Zhu, Peizhan Chen, Yisha Gao, Na Ta, Yunshuo Zhang, Jialin Cai, Yong Zhao, Shupeng Liu, Jianming Zheng
The long non-coding RNA maternally expressed gene 3 (MEG3) is frequently dysregulated in human cancers; however, its roles in colorectal cancer (CRC) development are largely unknown. Here, we reported that MEG3 was down-regulated in CRC tissues and CRC patients with lower MEG3 showed poorer overall survival and disease-free survival than those with higher MEG3 level. MEG3 over-expression represses CRC cells proliferation and migration in vivo and in vitro, while MEG3 knockdown leads to the enhanced proliferation and metastasis of CRC cells...
March 31, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29624920/lack-of-association-between-vitamin-d-receptor-bsmi-apai-polymorphisms-and-osteoporosis-risk-a-pooled-analysis-on-chinese-individuals
#11
Qing-Xian Wang, Shi-Meng Zhao, Ya-Bin Zhou, Cheng Zhang
BACKGROUND: As for the association between vitamin D receptor (VDR) gene polymorphisms and osteoporosis, the current results have yielded conflicts. Therefore, we performed a pooled analysis based on Chinese individuals to provide comprehensive data on the association between VDR BsmI, ApaI, Tru9I polymorphisms and osteoporosis risk. METHODS: Studies were identified using PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure and Chinese Biology Medicine databases through to January 2017...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29608804/relationship-between-vitamin-d-receptor-gene-polymorphism-and-susceptibility-to-chronic-kidney-disease-and-periodontal-disease-in-community-dwelling-elderly
#12
A Yoshihara, N Kaneko, M Iwasaki, K Nohno, H Miyazaki
OBJECTIVES: The aim of this study was to investigate the possible correlation between vitamin D receptor (VDR) gene polymorphism and susceptibility to chronic kidney disease (CKD) and periodontal disease. MATERIAL AND METHODS: This study analyzed 345 participants, who were all 79 years of age. Kidney function levels were determined based on the estimated glomerular filtration rate (eGFR) (non-reduced function: ≥60, and reduced function: <60 mL/min/1.73 m2 )...
April 2, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29604361/the-vitamin-d-receptor-regulates-mir-140-5p-and-targets-the-mapk-pathway-in-bone-development
#13
Wenting Luo, Lingli Liu, Liping Yang, Yaping Dong, Tianjing Liu, Xiaowei Wei, Dan Liu, Gu Hui, Juan Kong, Zhengwei Yuan, Qun Zhao
BACKGROUND: Skeletal development is a complicated process. The status of vitamin D (VD) is closely related to fetal bone development in the embryonic period. Recently, miRNAs have been found to participate in the regulation of skeletal growth and development in several species. However, the mechanisms underlying the interactions among vitamin D, its receptor (VDR), and miRNAs during the process of bone development remain unclear. The aim of this study was to identify miRNAs that are regulated by 1,25(OH)2 D3 in murine osteoblasts and to analyze the relationship and the effects of VD/VDR and miRNAs in vitro and in vivo...
March 28, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29600982/variant-of-rare-hermansky-pudlak-syndrome-associated-with-granulomatous-colitis-diagnostics-clinical-course-and-treatment
#14
L Y Lozynska, A Plawski, M R Lozynska, I Vytvytskyi, R Y Lozynskyi, N Prokopchuk, B Tretiak
AIM: To study the relationship between the genotype and the phenotype in the patients with Hermansky - Pudlak syndrome (HPS) associated with granulomatous colitis; to monitor clinical course of the disease for adequate treatment, cancer surveillance and genetic counseling. MATERIALS AND METHODS: The diagnosis of HPS is established by physical examination, chest X-ray, computed tomography, endoscopic examination with biopsy, and laboratory tests, including histology, baseline laboratory blood, urine and feces tests, determination of ASCA-C and ANCA antibodies using an ELISA...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29595145/feasibility-of-online-impt-adaptation-using-fast-automatic-and-robust-dose-restoration
#15
Kinga Bernatowicz, Xavier Geets, Ana Barragan, Guillaume Janssens, Kevin Souris, Edmond Sterpin
Intensity-modulated proton therapy (IMPT) offers excellent dose conformity and healthy tissue sparing, but it can be substantially compromised in the presence of anatomical changes. A major dosimetric effect is caused by density changes, which alter the planned proton range in the patient. Three different methods, which automatically restore an IMPT plan dose on a daily CT image were implemented and compared: (1) simple dose restoration (DR) using optimization objectives of the initial plan, (2) voxel-wise dose restoration (vDR), and (3) isodose volume dose restoration (iDR)...
March 29, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29594051/vitamin-d-in-graves-disease-levels-correlation-with-laboratory-and-clinical-parameters-and-genetics
#16
Tereza Planck, Bushra Shahida, Johan Malm, Jonas Manjer
Objective: The aim was to compare the vitamin D levels in patients with Graves disease (GD) with the general population and to correlate the vitamin D levels with laboratory and clinical parameters in GD. Moreover, we examined the genetic variation in genes involved in the vitamin D metabolism and their association with GD. Methods: The levels of vitamin D were compared in 292 patients with newly diagnosed GD and 2,305 controls. Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR), vitamin D binding protein (DBP), and 1-α-hydroxylase ( CYP27B1 ) were examined for association with GD and/or Graves ophthalmopathy (GO) in 708 patients and 1,178 controls...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29593729/genomic-effects-of-the-vitamin-d-receptor-potentially-the-link-between-vitamin-d-immune-cells-and-multiple-sclerosis
#17
REVIEW
Ming Lu, Bruce V Taylor, Heinrich Körner
Vitamin D has a plethora of functions that are important for the maintenance of general health and in particular, the functional integrity of the immune system, such as promoting an anti-inflammatory cytokine profile and reducing the Treg/Th17 ratio. Multiple sclerosis (MS) is a chronic, inflammatory, and neurodegenerative central nervous system (CNS) disorder of probable autoimmune origin. MS is characterized by recurring or progressive demyelination and degeneration of the CNS due in part to a misguided immune response to as yet undefined (CNS) antigens, potentially including myelin basic protein and proteolipid protein...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29593721/vitamin-d-in-human-immunodeficiency-virus-infection-influence-on-immunity-and-disease
#18
REVIEW
María Ángeles Jiménez-Sousa, Isidoro Martínez, Luz María Medrano, Amanda Fernández-Rodríguez, Salvador Resino
People living with human immunodeficiency virus (HIV) infection typically have hypovitaminosis D, which is linked to a large number of pathologies, including immune disorders and infectious diseases. Vitamin D (VitD) is a key regulator of host defense against infections by activating genes and pathways that enhance innate and adaptive immunity. VitD mediates its biological effects by binding to the Vitamin D receptor (VDR), and activating and regulating multiple cellular pathways. Single nucleotide polymorphisms in genes from those pathways have been associated with protection from HIV-1 infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29589202/the-impact-of-five-vdr-polymorphisms-on-multiple-sclerosis-risk-and-progression-a-case-control-and-genotype-phenotype-study
#19
Pavel Křenek, Yvonne Benešová, Julie Bienertová-Vašků, Anna Vašků
Vitamin D receptor polymorphisms have been the target of many studies focusing on multiple sclerosis. However, previously reported results have been inconclusive. The objective of this study was to investigate the association between five vitamin D receptor polymorphisms (EcoRV, FokI, ApaI, TaqI, and BsmI) and multiple sclerosis susceptibility and its course. The study was carried out as a case-control and genotype-phenotype study, consisted of 296 Czech multiple sclerosis patients and 135 healthy controls...
March 28, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29581858/depleting-ovarian-cancer-stem-cells-with-calcitriol
#20
Amit Kumar Srivastava, Asim Rizvi, Tiantian Cui, Chunhua Han, Ananya Banerjee, Imrana Naseem, Yanfang Zheng, Altaf A Wani, Qi-En Wang
Cancer stem cells (CSCs) represent the root of many solid tumors including ovarian cancer. Eradication of CSCs represents a novel cancer therapeutic strategy. Calcitriol, also known as 1,25-dihydroxyvitamin D3 [1,25(OH)2 D3 ], is an active metabolite of vitamin D, functioning as a potent steroid hormone. Calcitriol has shown anti-tumor effects in various cancers by regulating multiple signaling pathways. It has been reported that calcitriol can regulate the properties of normal and CSCs. However, the effect of calcitriol on the ovarian cancer growth and ovarian CSCs is still unclear...
March 6, 2018: Oncotarget
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