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https://www.readbyqxmd.com/read/29218094/mir-351-negatively-regulates-osteoblast-differentiation-of-mscs-induced-by-cholesten-3-one-through-targeting-vdr
#1
Qiuke Hou, Yongquan Huang, Yiwen Luo, Bin Wang, Yamei Liu, Rudong Deng, Saixia Zhang, Fengbin Liu, Dongfeng Chen
Our previous reports indicated that (+)-cholesten-3-one induces osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) by activating vitamin D receptor (VDR). However, whether and how miRNAs modulate osteogenic differentiation induced by (+)-cholesten-3-one have not been explored. In this study, miRNA array profiling and further validation by quantitative real-time PCR revealed that miR-351 was downregulated during (+)-cholesten-3-one-induced osteogenic differentiation of MSCs. Overexpression of miR-351 by miR-351 precursor transfection markedly inhibited the expression of osteoblast-specific genes, such as alkaline phosphatase (ALP), collagen type II, osteopontin (OPN), and runt-related transcription factor 2 (RUNX2), which consequently decreased a number of calcium mineralized nodules...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29209434/vitamin-d-in-the-prevention-prediction-and-treatment-of-neurodegenerative-and-neuroinflammatory-diseases
#2
REVIEW
Priscilla Koduah, Friedemann Paul, Jan-Markus Dörr
Vitamin D research has gained increased attention in recent times due to its roles beyond bone health and calcium homeostasis, such as immunomodulation. In some parts of the brain and on immune cells, vitamin D hydroxylating enzymes and its receptors are located. Epidemiological evidence demonstrates that deficiency of Vitamin D is relevant for disease risk and course in multiple sclerosis (MS) and presumably also in neuromyelitis optica spectrum disorders (NMOSD), Parkinson's disease (PD), and Alzheimer's disease (AD)...
December 2017: EPMA Journal
https://www.readbyqxmd.com/read/29208972/effects-of-1-25-and-24-25-vitamin-d-on-corneal-epithelial-proliferation-migration-and-vitamin-d-metabolizing-and-catabolizing-enzymes
#3
Xiaowen Lu, Zhong Chen, Namratha Mylarapu, Mitchell A Watsky
This study investigated the effects of 1,25(OH)2D3 and 24R,25(OH)2D3 on corneal epithelial cell proliferation, migration, and on the vitamin D activating enzyme CYP27B1 (produces 1,25(OH)2D3) and inactivating enzyme CYP24A1 (produces 24R,25(OH)2D3). The role of the vitamin D receptor (VDR) was also examined. In VDR wildtype mouse corneal epithelial cells (WT), 1,25(OH)2D3 increased CYP24A1 protein expression and decreased CYP27B1 expression. In VDR knockout mouse epithelial cells (KO), 1,25(OH)2D3 increased CYP24A1 and CYP27B1 protein expression...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208668/a-polymorphism-within-the-vitamin-d-transporter-gene-predicts-outcome-in-metastatic-colorectal-cancer-patients-treated-with-folfiri-bevacizumab-or-folfiri-cetuximab
#4
Martin D Berger, Sebastian Stintzing, Volker Heinemann, Shu Cao, Dongyun Yang, Yu Sunakawa, Satoshi Matsusaka, Yan Ning, Satoshi Okazaki, Yuji Miyamoto, Mitsukuni Suenaga, Marta Schirripa, Diana L Hanna, Shivani Soni, Alberto Puccini, Wu Zhang, Chiara Cremolini, Alfredo Falcone, Fotios Loupakis, Heinz-Josef Lenz
PURPOSE: Vitamin D exerts its inhibitory influence on colon cancer growth by inhibiting Wnt signaling and angiogenesis. We hypothesized that SNPs in genes involved in vitamin D transport, metabolism and signaling are associated with outcome in metastatic colorectal cancer (mCRC) patients treated with first-line FOLFIRI and bevacizumab (bev). EXPERIMENTAL DESIGN: 522 mCRC patients enrolled in the FIRE-3 (discovery cohort) and TRIBE (validation set) trials treated with FOLFIRI/bev were included in this study...
December 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29208185/association-between-vitamin-d-receptor-bsmi-gene-polymorphism-and-periodontitis-a-meta-analysis-in-a-single-ethnic-group
#5
Ting Cai, Zheng-Yan Yang, Li Nie, Jia-Xiu Zhen, Li Deng, Zhi Zhou
Although many researchers have studied on the association between vitamin D receptor (VDR) BsmI polymorphism and periodontitis, this association remains elusive. To further assess the effects of VDR BsmI polymorphism on the risk of periodontitis, a meta-analysis was performed in a single ethnic group. We searched PubMed and Chinese databases for relevant studies till April 2017. The strength of the associations were assessed used pooled odds ratios (ORs) and 95% confidence intervals (CIs). Six studies including 757 periodontitis cases and 670 controls were identified at last...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29208176/analysis-of-potential-interactions-between-vitamins-d-and-c-using-gene-expression-profiles-from-mouse-models
#6
Yan Jiao, Mingming Niu, Cheng Tian, Jian Yan, Aron W Vancil, Xuenan Yan, Ming Zhang
Vitamin D (VD) and vitamin C (VC) have been recognized as essential elements for human health.  Animal models, especially mouse models, have been widely used in the study of VD and VC. This study is to investigate how VD and VC interact at molecular level using whole genome expression profiles from spleens of 111 mouse strains and livers from 40 mouse strains. We first identified the genes that are closely correlated to vitamin D receptor (Vdr) and gulonolactone oxidase (Lgo). We next analyzed the potential molecular pathways of Vdrand Lgo correlated genes and examined how these two sets of pathways are connected in liver and spleen...
November 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29205876/vitamin-d-does-not-play-a-functional-role-in-adipose-tissue-development-in-rodent-models
#7
Alexandra Schutkowski, Daniela Max, Markus Bönn, Corinna Brandsch, Sarah M Grundmann, Frank Hirche, Martin S Staege, Gabriele I Stangl
SCOPE: Several studies have proposed a role of vitamin D in adipogenesis. Here, we sought to study the impact of the vitamin D receptor (Vdr) on adipocyte size in young and old mice and the effect of maternal vitamin D deficiency on fetal adipogenesis. METHODS AND RESULTS: Histological analysis of adipose tissues showed that Vdr knockout (KO) mice had smaller adipocytes than wild-type (WT) mice. Next, we compared young and old Vdr-KO and WT mice and found no differences in adipocyte sizes between weaned Vdr-KO mice and WT mice...
December 5, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29204386/identification-of-genotypes-and-allelic-frequencies-of-vitamin-d-receptor-gene-polymorphism-taqi-in-egyptian-melasma-patients
#8
Iman Seleit, Ola Ahmed Bakry, Eman Masoud, Shaimaa Nabil
Background: Melasma is a characteristic pattern of facial hyperpigmentation, occurring primarily on the forehead, cheeks, and chin, in a mask-like distribution. The pathogenesis of melasma is not fully understood. Vitamin D plays a role in skin pigmentation. It exerts its effect through vitamin D receptor (VDR), which is expressed in variable cells including normal melanocytes. Aim and Objective: The aim of the current work was to investigate if VDR gene polymorphism (TaqI) confers susceptibility to melasma in Egyptian patients...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29201067/hereditary-vitamin-d-resistant-rickets-clinical-laboratory-and-genetic-characteristics-of-2-iranian-siblings
#9
Ali A Ghazi, Azita Zadeh-Vakili, Marjan Zarif Yeganeh, Shahram Alamdari, Atieh Amouzegar, Ali Akbar Khorsandi, Alireza Amirbaigloo, Fereidoun Azizi
Purpose and Methods: Hereditary vitamin D resistant rickets (HVDRR) is a rare disease that presents with signs and symptoms of rickets, alopecia, and growth retardation during the early years of life. The disease is caused by mutations in the vitamin D receptor (VDR) gene, which leads to unresponsiveness of the mutant receptor to 1-25(OH) 2 D3. The disease is transmitted as an autosomal recessive disorder and is found with equal frequency in males and females. The disease is rarely encountered and only about 100 cases are reported so far...
July 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29187432/paclitaxel-carboplatin-and-1-25-d3-inhibit-proliferation-of-endometrial-cancer-cells-in-vitro
#10
Tea Kuittinen, Päivi Rovio, Synnöve Staff, Tiina Luukkaala, Anne Kallioniemi, Seija Grénman, Marita Laurila, Johanna Mäenpää
BACKGROUND/AIM: Endometrial cancer cells are known to be sensitive to carboplatin and paclitaxel. Furthermore, vitamin D (1,25-D3) has been reported to inhibit endometrial cancer cell growth both as a single agent and combined with carboplatin. However, there are no studies comparing the effect of paclitaxel and carboplatin as single agents vs. in combination in endometrial cancer cell lines. Neither has the effect of 1,25-D3 been studied with paclitaxel. The present study investigated the effect of paclitaxel, carboplatin and 1,25-D3 on the growth of endometrial cancer cells in vitro...
December 2017: Anticancer Research
https://www.readbyqxmd.com/read/29186865/role-of-vitamin-d-in-maintaining-renal-epithelial-barrier-function-in-uremic-conditions
#11
Milos Mihajlovic, Michele Fedecostante, Miriam J Oost, Sonja K P Steenhuis, Eef G W M Lentjes, Inge Maitimu-Smeele, Manoe J Janssen, Luuk B Hilbrands, Rosalinde Masereeuw
As current kidney replacement therapies are not efficient enough for end-stage renal disease (ESRD) treatment, a bioartificial kidney (BAK) device, based on conditionally immortalized human proximal tubule epithelial cells (ciPTEC), could represent an attractive solution. The active transport activity of such a system was recently demonstrated. In addition, endocrine functions of the cells, such as vitamin D activation, are relevant. The organic anion transporter 1 (OAT-1) overexpressing ciPTEC line presented 1α-hydroxylase (CYP27B1), 24-hydroxylase (CYP24A1) and vitamin D receptor (VDR), responsible for vitamin D activation, degradation and function, respectively...
November 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29186386/gene-expression-pattern-in-response-to-cholecalciferol-supplementation-highlights-cubilin-as-a-major-protein-of-25-oh-d-uptake-in-adipocytes-and-male-mice-white-adipose-tissue
#12
Lauriane Bonnet, Esma Karkeni, Charlène Couturier, Julien Astier, Julie Dalifard, Catherine Defoort, Ljubica Svilar, Jean-Charles Martin, Franck Tourniaire, Jean-François Landrier
It is well established that the active form of vitamin D, i.e. 1,25(OH)2D, regulates the expression of genes involved in its own metabolism and transport in the kidney, and possibly in the liver. However, little is known about the transcriptional impact of cholecalciferol supplementation on white adipose tissue (WAT) and adipocytes, which are a major site of vitamin D and 25(OH)D storage in the organism. To fill this gap, we investigated the impact of cholecalciferol supplementation in WAT via a panel of genes coding for enzymes and proteins involved in vitamin D metabolism and uptake...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29183808/the-vitamin-d-receptor-vdr-binds-to-the-nuclear-matrix-via-its-hinge-domain-a-potential-mechanism-for-the-reduction-in-vdr-mediated-transcription-in-mitotic-cells
#13
Xiaoying Cui, Renata Pertile, Darryl W Eyles
Vitamin D is best known for its regulation of calcium homeostasis. Vitamin D exerts its genomic actions via the vitamin D receptor (VDR). As a member of the superfamily of nuclear receptors, the VDR is primarily located within the nucleus of non-dividing cells. We show here that the VDR relocates from the nucleus into the cytoplasm across all stages of cell division in CHO cells. Furthermore, we show that the VDR is transcriptionally inert during cell division. In addition, 1α, 25 dihydroxyvitamin D (1,25(OH)2D3) promotes VDR binding to the nuclear matrix...
November 25, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29183090/serum-vitamin-d-status-vitamin-d-receptor-polymorphism-and-glucose-homeostasis-in-healthy-subjects
#14
Otto Mayer, Jitka Seidlerová, Václava Černá, Alena Kučerová, Petra Karnosová, Markéta Hronová, Peter Wohlfahrt, Radka Fuchsová, Jan Filipovský, Renata Cífková, Ondřej Topolčan, Martin Pešta
Low vitamin D status has been frequently associated with impaired glucose metabolism. We examined associations between 25-hydroxyvitamin D (25-OH-D) and several parameters of glucose homeostasis in virtually healthy subjects, and explored possible interaction with vitamin D receptor (VDR) polymorphism. Nondiabetic subjects without chronic medication or any known significant manifest disease were selected from large general-population based population survey. Insulin sensitivity and β cell secretion were calculated by homeostasis model assessment (HOMA) and soluble isoform of receptor for advanced glycation end-products (sRAGE) using commercial ELISA...
November 28, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29181077/updated-analysis-of-vitamin-d-receptor-gene-foki-polymorphism-and-prostate-cancer-susceptibility
#15
Yuan-Yuan Mi, Yang-Zhi Chen, Jing Chen, Li-Feng Zhang, Li Zuo, Jian-Gang Zou
Introduction: Polymorphisms of the vitamin D receptor (VDR) gene have been investigated in various case-control studies to evaluate prostate cancer susceptibility; however, published data on the association between vitamin D receptor gene FokI polymorphism and prostate cancer risk are inconclusive. Material and methods: To assess the impact of vitamin D receptor gene FokI polymorphism, we performed a meta-analysis of eligible studies including 9,720 patients and 9,710 control subjects...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29178579/vitamin-d-receptor-expression-in-canine-mammary-gland-and-relationship-with-clinicopathological-parameters-and-progesterone-oestrogen-receptors
#16
R Sánchez-Céspedes, M D Fernández-Martínez, A Raya, C Pineda, I López, Y Millán
The vitamin D receptor (VDR) belongs to the nuclear class II receptor family. VDR is a ligand transcription factor and mediates the actions of calcitriol, the active product of vitamin D synthesis. Nowadays, it is known that the biological actions of calcitriol include the capacity to modulate cancer features, such as proliferation and differentiation, apoptosis, angiogenesis, invasion and metastasis. VDR expression has been demonstrated in human breast cancer and vitamin D has emerged as a promising targeted therapy...
November 27, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/29176823/vitamin-d-receptor-is-present-on-the-neuronal-plasma-membrane-and-is-co-localized-with-amyloid-precursor-protein-adam10-or-nicastrin
#17
Erdinç Dursun, Duygu Gezen-Ak
Our recent study indicated that vitamin D and its receptors are important parts of the amyloid processing pathway in neurons. Yet the role of vitamin D receptor (VDR) in amyloid pathogenesis is complex and all regulations over the production of amyloid beta cannot be explained solely with the transcriptional regulatory properties of VDR. Given that we hypothesized that VDR might exist on the neuronal plasma membrane in close proximity with amyloid precursor protein (APP) and secretase complexes. The present study primarily focused on the localization of VDR in neurons and its interaction with amyloid pathology-related proteins...
2017: PloS One
https://www.readbyqxmd.com/read/29176261/reduced-vitamin-d-receptor-on-circulating-endothelial-progenitor-cells-a-new-risk-factor-of-coronary-artery-diseases
#18
Sidi Ai, Zhiqing He, Ru Ding, Feng Wu, Zhigang Huang, Jiamei Wang, Shuaibo Huang, Xianliang Dai, Jiayou Zhang, Jing Chen, Linlin Liu, Zonggui Wu, Chun Liang
AIM: Endothelial progenitor cells (EPCs) are shown to participate in the pathological processes of atherosclerosis. While Vitamin D and its receptor axis might exert some effects on EPCs' function. But their exact relationship with clinical patients is still elusive, which inspired us to explore the potential association of vitamin D receptor (VDR) expression on circulating EPCs and serum vitamin D levels among patients with coronary artery disease (CAD). METHODS: Two hundred patients with CAD after their admission to hospital and one hundred healthy controls were enrolled...
November 24, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29175793/role-of-alad-and-vdr-genotypes-on-the-association-of-low-blood-lead-level-with-serum-uric-acid-and-blood-pressure-in-automobile-paint-workers-of-karachi-pakistan
#19
Sadia Sadaf, Afaq Ahmed Siddiqui, Maqsood Ali Ansari
Lead is an environmental pollutant having nephrotoxic effects even at low level. Its continuous exposure is associated with increased serum uric acid level that resulting in renal insufficiency. This research was conducted to see the effects of delta-aminolevulinic acid dehydratase (ALAD) and vitamin D receptor (VDR) genotypes on biochemical parameters and blood pressure (BP) of automobile workers having low blood lead level (BLL) with continuous lead exposure. Automobile paints workers with ALAD 1-2 genotype showed the positive association of BLL with diastolic BP (p<0...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29175129/vitamin-d-metabolic-loci-and-vitamin-d-status-in-black-and-white-pregnant-women
#20
Katharyn M Baca, Manika Govil, Joseph M Zmuda, Hyagriv N Simhan, Mary L Marazita, Lisa M Bodnar
BACKGROUND: Several candidate genes and genome wide association studies have reported significant associations between vitamin D metabolism genes and 25-hydroxyvitamin D. Few studies have examined these relationships in pregnancy. OBJECTIVE: We evaluated the relationship between maternal allelic variants in three vitamin D metabolism genes and 25-hydroxyvitamin D (25(OH)D) concentration in pregnancy. STUDY DESIGN: In two case-control studies, samples were drawn from women who delivered at Magee Womens Hospital in Pittsburgh, PA from 1999 to 2010 and twelve recruiting sites across the United States from 1959 to 65...
November 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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