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https://www.readbyqxmd.com/read/27913313/the-role-of-vitamin-d-and-vdr-in-carcinogenesis-through-epidemiology-and-basic-sciences
#1
REVIEW
Borja Bandera Merchan, Sonsoles Morcillo, Gracias Martin-Nuñez, Francisco José Tinahones, Manuel Macías-González
In the last two decades vitamin D (VD) research has demonstrated new extraskeletal actions of this pre-hormone, suggesting a protective role of this secosteroid in the onset, progression and prognosis of several chronic noncommunicable diseases, such as cardiovascular disease, diabetes mellitus or cancer. Regarding carcinogenesis, both preclinical and epidemiological evidence available show oncoprotective actions of VD and its receptor, the VDR. However, in late neoplastic stages the VD system (VDS) seems to be less functional, which appears to be due to an epigenetic silencing of the system...
November 29, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27913273/the-endocrine-vitamin-d-system-in-the-gut
#2
Antonio Barbáchano, Asunción Fernández-Barral, Gemma Ferrer-Mayorga, Alba Costales-Carrera, María Jesús Larriba, Alberto Muñoz
The active vitamin D metabolite 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) has important regulatory actions in the gut through endocrine and probably also intracrine, autocrine and paracrine mechanisms. By activating the vitamin D receptor (VDR), which is expressed at a high level in the small intestine and colon, 1,25(OH)2D3 regulates numerous genes that control gut physiology and homeostasis. 1,25(OH)2D3 is a major responsible for epithelial barrier function and calcium and phosphate absorption, and the host's defense against pathogens and the inflammatory response by several types of secretory and immune cells...
November 29, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27906437/vitamin-d-receptor-polymorphisms-as-tool-for-early-screening-of-severe-bone-loss-in-women-patients-with-rheumatoid-arthritis
#3
G Di Spigna, A Del Puente, B Covelli, E Abete, E Varriale, S Salzano, L Postiglione
OBJECTIVE: Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease that leads to local and systemic arthritis and bone loss. Exploring genetic markers of candidate genes in osteoporosis and inflammatory cytokine genes could be a useful tool for the early identification of bone loss and fracture risk in RA patients. The target of this study is the evaluation and correlation between of Single Nucleotide Polymorphisms (SNPs) of Vitamin D Receptor (VDR) and possible effects on bone loss in RA...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27902451/vitamin-d-and-male-reproductive-system
#4
Pablo R Costanzo, Pablo Knoblovits
Vitamin D deficiency is a highly prevalent worldwide condition and affects people of all ages. The most important role of vitamin D is the regulation of intestinal calcium absorption and metabolism of calcium and phosphorus to maintain muscle and bone homeostasis. Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs...
December 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27898044/dna-damage-inducible-transcript-4-is-an-innate-surveillant-of-hair-follicular-stress-in-vitamin-d-receptor-knockout-mice-and-a-regulator-of-wound-re-epithelialization
#5
Hengguang Zhao, Sandra Rieger, Koichiro Abe, Martin Hewison, Thomas S Lisse
Mice and human patients with impaired vitamin D receptor (VDR) signaling have normal developmental hair growth but display aberrant post-morphogenic hair cycle progression associated with alopecia. In addition, VDR(-/-) mice exhibit impaired cutaneous wound healing. We undertook experiments to determine whether the stress-inducible regulator of energy homeostasis, DNA damage-inducible transcript 4 (Ddit4), is involved in these processes. By analyzing hair cycle activation in vivo, we show that VDR(-/-) mice at day 14 exhibit increased Ddit4 expression within follicular stress compartments...
November 26, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27897272/analysis-of-the-interaction-of-calcitriol-with-the-disulfide-isomerase-erp57
#6
Elisa Gaucci, Domenico Raimondo, Caterina Grillo, Laura Cervoni, Fabio Altieri, Giulio Nittari, Margherita Eufemi, Silvia Chichiarelli
Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane-associated receptor, which has been discovered as the disulfide isomerase ERp57. The aim of our research is to identify the binding sites for calcitriol in ERp57 and to analyze their interaction. We first studied the interaction through bioinformatics and fluorimetric analyses. Subsequently, we focused on two protein mutants containing the predicted interaction domains with calcitriol: abb'-ERp57, containing the first three domains, and a'-ERp57, the fourth domain only...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896829/immunomodulatory-and-immunosuppressive-roles-of-1%C3%AE-25-oh-2d3-in-autoimmune-diseases
#7
REVIEW
Hussaini Alhassan Mohammed, Ali Akbar Saboor-Yaraghi, Abbas Mirshafiey, Haumayon Vahedi, Mohammad Reza Shiri-Shahsavar, Ateke Mousavi Nasl Khameneh
BACKGROUND: Autoimmune diseases are pathological conditions characterized by abnormal. responses, accompanied by auto-antibodies to self-molecules. The roles vitamin D in autoimmune diseases has increased significantly in the recent past from its functions in calcium and phosphate homeostasis, it is now involved in the regulations and proliferations of Th1 and Th17 lymphocyte. 1α,25(OH)2D3 in very important in ameliorations of inflammatory disorders arising from autoimmune diseases, but the mechanism by which this is done is still a bone of contentions...
November 29, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27895587/vitamin-d-signaling-through-induction-of-paneth-cell-defensins-maintains-gut-microbiota-and-improves-metabolic-disorders-and-hepatic-steatosis-in-animal-models
#8
Danmei Su, Yuanyang Nie, Airu Zhu, Zishuo Chen, Pengfei Wu, Li Zhang, Mei Luo, Qun Sun, Linbi Cai, Yuchen Lai, Zhixiong Xiao, Zhongping Duan, Sujun Zheng, Guihui Wu, Richard Hu, Hidekazu Tsukamoto, Aurelia Lugea, Zhenqui Liu, Stephen J Pandol, Yuan-Ping Han
Metabolic syndrome (MetS), characterized as obesity, insulin resistance, and non-alcoholic fatty liver diseases (NAFLD), is associated with vitamin D insufficiency/deficiency in epidemiological studies, while the underlying mechanism is poorly addressed. On the other hand, disorder of gut microbiota, namely dysbiosis, is known to cause MetS and NAFLD. It is also known that systemic inflammation blocks insulin signaling pathways, leading to insulin resistance and glucose intolerance, which are the driving force for hepatic steatosis...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27895321/is-nasal-polyposis-related-to-levels-of-serum-vitamin-d-and-vitamin-d-receptor-gene-expression
#9
Omer Erdag, Mahfuz Turan, Rıfkı Ucler, Mehmet Berkoz, Mehmet Fatih Garca, Nazım Bozan, Ahmet Faruk Kıroglu, Hakan Cankaya
BACKGROUND Nasal polyposis (NP) is the most frequent cause of nasal masses. Despite considerable research on the subject, its etiology has not been fully elucidated, and effective treatment methods have not been developed. Some etiological factors causing low or high expression of genes in genetically predisposed individuals may play a role in the pathogenesis of the disease. The purpose of this study was to assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP...
November 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27891515/the-association-between-vdr-gene-polymorphisms-and-diabetic-retinopathy-susceptibility-a-systematic-review-and-meta-analysis
#10
Yun Zhang, Wei Xia, Ping Lu, Huijuan Yuan
Aims. Studies on the associations of vitamin D receptor (VDR) gene polymorphisms with diabetic retinopathy (DR) susceptibility reported conflicting results. A systematic meta-analysis was undertaken to clarify this topic. Methods. A systematic search of electronic databases (PubMed, EMBASE, and CNKI) was carried out until March 31, 2016. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of the association. Results. A total of 7 studies fulfilling the inclusion criteria were included in this meta-analysis (649 cases and 707 controls)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27890450/src2-3-binds-to-vitamin-d-receptor-with-high-sensitivity-and-strong-affinity
#11
Daichi Egawa, Toshimasa Itoh, Akira Kato, Saori Kataoka, Yasuaki Anami, Keiko Yamamoto
Vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and regulates the expression of target genes through ligand binding. To express the target gene, coactivator binding to the VDR/ligand complex is essential. Although there are many coactivators in living cells, precise interactions between coactivators and VDR have not been clarified. Here, we synthesized two coactivator peptides, DRIP205-2 and SRC2-3, evaluated their affinity for the ligand-binding domain (LBD) of VDR using 1α,25-dihydroxyvitamin D3, partial agonist 1, and antagonist 2 by surface plasmon resonance (SPR), and assessed their interaction modes with VDR-LBD using X-ray crystallographic analysis...
November 14, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27889974/-vitamin-d-metabolism-and-signaling-in-human-hepatocellular-carcinoma-and-surrounding-non-tumorous-liver
#12
Evelin Horváth, Bernadett Balla, János Kósa, Péter András Lakatos, Áron Lazáry, Dániel Németh, Hasan Jozilan, Áron Somorácz, Anna Korompay, Benedek Gyöngyösi, Katalin Borka, András Kiss, Péter Kupcsulik, Zsuzsa Schaff, Ferenc Szalay
INTRODUCTION: 1,25-Dihydroxy vitamin D3 mediates antitumor effects in hepatocellular carcinoma. AIM: We examined mRNA and protein expression differences in 1,25-Dihydroxy vitamin D3-inactivating CYP24A1, mRNA of activating CYP27B1 enzymes, and that of VDR between human hepatocellular carcinoma and surrounding non-tumorous liver. METHODS: Snap-frozen tissues from 13 patients were studied for mRNA and protein expression of CYP24A1. Paraffin-embedded tissues from 36 patients were used to study mRNA of VDR and CYP27B1...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27889775/vitamin-d-receptor-taqi-gene-polymorphism-and-dental-caries-in-czech-children
#13
Lydie Izakovicova Holla, Petra Borilova Linhartova, Jakub Kastovsky, Michaela Bartosova, Kristina Musilova, Lubomir Kukla, Martina Kukletova
AIM: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. METHODS: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT ≥1), were genotyped by the TaqMan method. RESULTS: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0...
November 26, 2016: Caries Research
https://www.readbyqxmd.com/read/27871908/acetylated-deoxycholic-dca-and-cholic-ca-acids-are-potent-ligands-of-pregnane-x-pxr-receptor
#14
Alejandro Carazo, Lucie Hyrsova, Jan Dusek, Hana Chodounska, Alzbeta Horvatova, Karel Berka, Vaclav Bazgier, Hongying Gan-Schreier, Waleé Chamulitrat, Eva Kudova, Petr Pavek
The Pregnane X (PXR), Vitamin D (VDR) and Farnesoid X (FXR) nuclear receptors have been shown to be receptors of bile acids controlling their detoxification or synthesis. Chenodeoxycholic (CDCA) and lithocholic (LCA) acids are ligands of FXR and VDR, respectively, whereas 3-keto and acetylated derivates of LCA have been described as ligands for all three receptors. In this study, we hypothesized that oxidation or acetylation at position 3, 7 and 12 of bile acids DCA (deoxycholic acid), LCA, CA (cholic acid), and CDCA by detoxification enzymes or microbiome may have an effect on the interactions with bile acid nuclear receptors...
November 18, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27864003/novel-screening-system-for-high-affinity-ligand-of-heredity-vitamin-d-resistant-rickets-associated-vitamin-d-receptor-mutant-r274l-using-bioluminescent-sensor
#15
Hiroki Mano, Miyu Nishikawa, Kaori Yasuda, Shinichi Ikushiro, Nozomi Saito, Daisuke Sawada, Shinobu Honzawa, Masashi Takano, Atsushi Kittaka, Toshiyuki Sakaki
Hereditary vitamin D-resistant rickets (HVDRR) is caused by mutations in the vitamin D receptor (VDR) gene. Arg274 located in the ligand binding domain (LBD) of VDR is responsible for anchoring 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3) by forming a hydrogen bond with the 1α-hydroxyl group of 1α,25(OH)2D3. The Arg274Leu (R274L) mutation identified in patients with HVDRR causes a 1000-fold decrease in the affinity for 1α,25(OH)2D3, and dramatically reduces vitamin D- related gene expression. Recently, we successfully constructed fusion proteins consisting of split-luciferase and LBD of the VDR...
November 15, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27862146/maternal-25-hydroxyvitamin-d-is-inversely-correlated-with-fetal-serotonin
#16
Padma Murthi, Miranda Davies-Tuck, Martha Lappas, Harmeet Singh, Joanne Mockler, Rahana Rahman, Rebecca Lim, Bryan Leaw, James Doery, Euan M Wallace, Peter R Ebeling
OBJECTIVE: Maternal vitamin D deficiency during pregnancy has been linked to impaired neurocognitive development in childhood. The mechanism by which vitamin D affects childhood neurocognition is unclear but may be via interactions with serotonin, a neurotransmitter involved in fetal brain development. In this study we aimed to explore associations between maternal and fetal vitamin D concentrations, and fetal serotonin concentrations at term. STUDY DESIGN AND MEASUREMENTS: Serum 25-hydroxyitamin D (25(OH)D, nmol/L) and serotonin (5-HT, nmol/L) concentrations were measured in maternal and umbilical cord blood from mother-infant pairs (n=64)...
November 12, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27861345/vitamin-d-receptor-gene-bsmi-polymorphisms-in-egyptian-children-and-adolescents-with-systemic-lupus-erythematosus-a-case-control-study
#17
Seham F Azab, Yasser F Ali, Mohsen A A Farghaly, Mohammed E Hamed, Mayy A N Allah, Ahmed A Emam, Nasser I Abdelsalam, Mustafa I A Hashem, Heba H Gawish, Rehab M Nabil, Lamiaa M Kamel, Dalia S Fahmy, Salah F Alsayed, Nashwa M Al Azizi, Ghada M Al-Akad, Maha A Noah, Hind M Abdelrahman, Ahmed R Ahmed, Eman A Bendary
Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. To date, only a few studies concerned the association of the VDR gene polymorphisms with childhood-onset SLE.In this study, we aimed to investigate the BsmI polymorphisms in the VDR gene, for the first time in Egyptian children and adolescents with SLE, to determine whether this polymorphism could be a marker of susceptibility to or severity of SLE and we also measured the serum level of 25-hydroxyvitamin D (25[OH] D) to assess its relation to such polymorphism...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856242/1-25-oh-2d3-induced-interaction-of-vitamin-d-receptor-with-p50-subunit-of-nf-%C3%AE%C2%BAb-suppresses-the-interaction-between-klf5-and-p50-contributing-to-inhibition-of-lps-induced-macrophage-proliferation
#18
Dong Ma, Ruo-Nan Zhang, Ya Wen, Wei-Na Yin, Disi Bai, Guo-Ying Zheng, Jin-Shui Li, Bin Zheng, Jin-Kun Wen
KLF5 and nuclear factor κB (NF-κB) regulate cell proliferation and inflammation. Vitamin D signaling through vitamin D receptor (VDR) exerts anti-proliferative and anti-inflammatory actions. However, an actual relationship between KLF5, NF-κB and VDR in the inflammation and proliferation of macrophages is still unclear. Here, we showed that LPS and proinflammatory cytokines stimulate KLF5 gene expression in macrophages, and that 1, 25(OH)2D3 suppresses LPS-induced KLF5 expression and cell proliferation via upregulation of VDR expression...
November 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27856225/correlations-of-vdr-and-vdbp-genetic-polymorphisms-with-susceptibility-to-adolescent-idiopathic-scoliosis-and-efficacy-of-brace-treatment
#19
Yu Wang, Zhi-Qiang Cui, Tian-Bao Luo, Long Liu
OBJECTIVE: This paper aimed to elucidate the correlations of VDR and VDBP polymorphisms with susceptibility to adolescent idiopathic scoliosis (AIS) and efficacy of brace treatment. METHODS: AIS patients and healthy controls were enrolled. Lumbar spine bone mineral density (LSBMD) and femoral neck bone mineral density (FNBMD) were detected by dual energy X-ray absorptiometry. VDR and VDBP polymorphisms were detected by PCR-RFLP. Efficacy of brace treatment was evaluated by Cobb measurement...
November 14, 2016: Genomics
https://www.readbyqxmd.com/read/27855629/vitamin-d-and-the-epigenetic-machinery-in-colon-cancer
#20
Meiyan Sun, Bin Guo
Vitamin D is an important hormone that regulates many physiological processes related to human health. Through its nuclear receptor, VDR, vitamin D controls gene expression through genetic and epigenetic mechanisms. Increasing data have demonstrated the anti-cancer activities of vitamin D in various cancers, including colon cancer. This review summarizes the recent progresses in our understanding of the molecular mechanisms of vitamin D and its interaction with the epigenetic machinery in colon cancer. Vitamin D changes the status of DNA methylation and histone modifications, resulting in the activation of tumor suppressors and inhibition of oncogenes...
November 17, 2016: Current Medicinal Chemistry
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