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JOURNAL ARTICLE
Alyssa Hochberg, Michael H Dahan, Hakan Yarali, Lan N Vuong, Sandro C Esteves
RESEARCH QUESTION: What clinical factors are associated with 'unexpected' poor or suboptimal responses to IVF ovarian stimulation per POSEIDON's criteria, and which AMH and AFC threshold values distinguish this population? DESIGN: Tri-centre retrospective cohort study (2015-2017) involving first-time IVF and ICSI cycles with conventional ovarian stimulation (≥150 IU/day of FSH). Eligibility criteria included sufficient ovarian reserve markers according to POSEIDON's classification (AMH ≥1...
January 30, 2024: Reproductive Biomedicine Online
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JOURNAL ARTICLE
Shihao Huang, Yingchun Li, Bingjie Wang, Zhihao Zhou, Yonglong Li, Lingjun Shen, Jinge Cong, Liuxin Han, Xudong Xiang, Jiawei Xia, Danhua He, Zhanlin Zhao, Ying Zhou, Qiwen Li, Guanqi Dai, Hanzhang Shen, Taoyan Lin, Aibing Wu, Junshuang Jia, Dong Xiao, Jing Li, Wentao Zhao, Xiaolin Lin
AIM: In 2019, to examine the functions of METTL3 in liver and underlying mechanisms, we generated mice with hepatocyte-specific METTL3 homozygous knockout (METTL3Δhep ) by simultaneously crossing METTL3fl/fl mice with Alb-iCre mice (GPT) or Alb-Cre mice (JAX), respectively. In this study, we explored the potential reasons why hepatocyte-specific METTL3 homozygous disruption by Alb-iCre mice (GPT), but not by Alb-Cre mice (JAX), resulted in acute liver failure (ALF) and then postnatal lethality...
April 22, 2024: Aging
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JOURNAL ARTICLE
Joseph O Magliozzi, Thomas J Rands, Sudati Shrestha, William C Simke, Niklas E Hase, M Angeles Juanes, Joshua B Kelley, Bruce L Goode
In response to pheromone Saccharomyces cerevisiae extend a mating projection. This process depends on the formation of polarized actin cables which direct secretion to the mating tip and translocate the nucleus for karyogamy. Here, we demonstrate that proper mating projection formation requires the formin Bni1, as well as the actin nucleation promoting activities of Bud6, but not the formin Bnr1. Further, Bni1 is required for pheromone gradient tracking. Our work also reveals unexpected new functions for Bil2 in the pheromone response...
April 24, 2024: Molecular Biology of the Cell
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JOURNAL ARTICLE
Piotr A Serwacki, Dariusz A Hareza, Anna Kujawska, Anna Pałka, Estera Jachowicz-Matczak, Agata Rybka-Grymek, Wioletta Świątek-Kwapniewska, Iwona Pawłowska, Zofia Gniadek, Karolina Gutkowska, Mateusz Gajda, Jadwiga Wójkowska-Mach
INTRODUCTION: The complex interplay between Acinetobacter spp., patients, and the environment has made it increasingly difficult to optimally treat patients infected with Acinetobacter spp., mainly due to rising antimicrobial resistance and challenges with surveillance. OBJECTIVES: This study evaluated carbapenem-resistance Acinetobacter baumannii (CRAB) isolates to determine their resistance profiles and the presence of specific β-lactamase enzymes to inform the use of CRAB surveillance upon hospital admission and regional empiric antibiotic therapies...
April 23, 2024: Polish Archives of Internal Medicine
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JOURNAL ARTICLE
Alyssa D Huff, Marlusa Karlen-Amarante, Luiz M Oliveira, Jan-Marino Ramirez
Obstructive sleep apnea (OSA) is a prevalent sleep-related breathing disorder that results in multiple bouts of intermittent hypoxia. OSA has many neurological and systemic comorbidities, including dysphagia, or disordered swallow, and discoordination with breathing. However, the mechanism in which chronic intermittent hypoxia (CIH) causes dysphagia is unknown. Recently, we showed the postinspiratory complex (PiCo) acts as an interface between the swallow pattern generator (SPG) and the inspiratory rhythm generator, the preBötzinger complex, to regulate proper swallow-breathing coordination (Huff et al...
April 24, 2024: ELife
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JOURNAL ARTICLE
Gabriele Liuzzi, Osvaldo Artimagnella, Simone Frisari, Antonello Mallamaci
Foxg1 masters telencephalic development via a pleiotropic control over its progression. Expressed within the central nervous system (CNS), L1 retrotransposons are implicated in progression of its histogenesis and tuning of its genomic plasticity. Foxg1 represses gene transcription, and L1 elements share putative Foxg1 binding motifs, suggesting the former might limit telencephalic expression (and activity) of the latter. We tested such prediction, in vivo as well as in engineered primary neural cultures, by loss- and gain-of-function approaches...
April 24, 2024: Development
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JOURNAL ARTICLE
Yao Kong, Yuanning Liu, Kaibiao Wang, Tao Wang, Chen Wang, Ben Ai, Hongli Jia, Guohui Pan, Min Yin, Zhengren Xu
We confirm the previously revised stereochemistry of spiroviolene by X-ray crystallographically characterizing a hydrazone derivative of 9-oxospiroviolane, which is synthesized by hydroboration/oxidation of spiroviolene followed by oxidation of the resultant hydroxy group. An unexpected thermal boron migration occurred during the hydroboration process of spiroviolene that resulted in the production of a mixture of 1α-hydroxyspiroviolane, 9α- and 9β-hydroxyspiroviolane after oxidation. The assertion of the cis -orientation of the 19- and 20-methyl groups provided further support for the revised cyclization mechanism of spiroviolene...
2024: Beilstein Journal of Organic Chemistry
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JOURNAL ARTICLE
K Pozniak, A Swain, G Currie, A Doherty-Kirby, D Grahovac, J Lebsack, W Campbell, C Humphreys, S Patterson, S Raha, J Whitley, O Kraus de Camargo
INTRODUCTION: Children and youth with disabilities and special healthcare needs, and their families, have been uniquely affected by the COVID-19 pandemic. However, the voices of children themselves are still not well represented in the existing literature. METHODS: This qualitative descriptive study used a combination of visual methods and interviews to learn about the experiences of Canadian children with disabilities (n=18) and their parents (n=14) during the COVID pandemic and into the post-pandemic period...
2024: Frontiers in Public Health
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JOURNAL ARTICLE
Maryem El Jaouhari, Karin Johnson, Helen Anyoti, Yuhui Xu, Charlotte Wells, Ashley Weeks, Allison Yeung, Amanda Shaw, Susanna Ogunnaike-Cooke
BACKGROUND: The Canadian Adverse Events Following Immunization Surveillance System (CAEFISS) is a comprehensive vaccine safety surveillance system that includes both passive and active surveillance of vaccines administered in Canada. This work presents a summary of adverse events following immunization (AEFI) nationally for 2018 and 2019. METHODS: Data extracted from CAEFISS included all AEFI reports received by the Public Health Agency of Canada by April 30, 2022, for vaccines marketed in Canada and administered between January 1, 2018, and December 31, 2019...
January 1, 2024: Canada Communicable Disease Report
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JOURNAL ARTICLE
Elissa Giang, Yuhui Xu, Thivya Naganathan, Natalia Abraham, Marie-Thérèse Bawolak, Battouli Said Salim, Ashley Weeks, Amanda Shaw, Susanna Ogunnaike-Cooke
BACKGROUND: Seasonal influenza vaccines (SIV) authorized for use in Canada have all undergone rigorous regulatory assessments for safety and effectiveness. Serious adverse events following immunization (AEFI) can occur, though they are rare. Continuous safety surveillance of vaccines during the post-marketing phase is a critical component of vaccination programs. This enables the detection of rare, late onset, or unexpected adverse events. An updated safety summary following the introduction of any new vaccines and/or formulations to immunization programs is necessary for refining the risk-benefit profile of a specific vaccine and maintaining public confidence...
January 1, 2024: Canada Communicable Disease Report
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JOURNAL ARTICLE
David L Williamson, Haisley M Windsor, Gabe Nagy
The unexpected finding that isotopomers (i.e., isotopic isomers) can be separated with high-resolution ion mobility spectrometry-mass spectrometry (IMS-MS) has raised new structural considerations affecting an ion's mobility, namely its center of mass (CoM) and moments of inertia (MoI). Unfortunately, thus far, no studies have attempted to experimentally isolate either CoM or MoI, as they are intrinsically linked by their definitions, where MoI is calculated in relation to CoM. In this study, we designed and synthesized four isotopically labeled tetrapropylammonium (TAA3) ions, each with a unique mass distribution...
April 24, 2024: Journal of the American Society for Mass Spectrometry
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JOURNAL ARTICLE
Naoki Fujimura, Shigeo Ichihashi, Tsuyoshi Shibata, Hitoshi Matsumura, Michiko Watanabe, Noriyasu Morikage, Yoshihiko Kurimoto, Hiroshi Banno, Hidetoshi Uchiyama, Hideaki Obara
PURPOSE: Recent reports of the Zenith Alpha abdominal endovascular graft (Zenith Alpha AAA, Cook, Inc., Bloomington, Indiana) have demonstrated an unexpectedly high incidence of limb graft occlusion (LGO). The purpose of this study was to prospectively evaluate the performance of the Zenith AAA in Japan, with a specific focus on LGO. MATERIALS AND METHODS: All endovascular aneurysm repairs (EVARs) for abdominal aortic aneurysms performed using the Zenith Alpha AAA from July 2020 to October 2021 in 23 Japanese hospitals were prospectively evaluated...
April 23, 2024: Journal of Endovascular Therapy
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REVIEW
Jae-Hyeong Park, Kye Hun Kim
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 has led to a global health crisis with substantial mortality and morbidity. To combat the COVID-19 pandemic, various vaccines have been developed, but unexpected serious adverse events including vaccine-induced thrombotic thrombocytopenia, carditis, and thromboembolic events have been reported and became a huddle for COVID-19 vaccination. Vaccine-related myocarditis (VRM) is a rare but significant adverse event associated primarily with mRNA vaccines...
April 1, 2024: Korean Circulation Journal
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JOURNAL ARTICLE
Xi-Yu Liu, Xiao-Hong Wang
OBJECTIVES: In comparison to the subjects without diabetes, a greater concentration of serum carbohydrate antigen 19 - 9 (CA 19 - 9) was observed in the subjects with diabetes. Nevertheless, since the occurrence of abnormal CA 19 - 9 is not widespread among the whole diabetic population, this phenomenon has not attracted enough attention. The prevalence of abnormal CA 19 - 9 in hospitalized patients with diabetes was the focus of our research...
April 24, 2024: BMC Endocrine Disorders
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JOURNAL ARTICLE
Matthias Przyklenk, Shreya Karmacharya, Debora Bonasera, Arthur-Lauri Pasanen-Zentz, Stanislav Kmoch, Mats Paulsson, Raimund Wagener, Gianmaria Liccardi, Alvise Schiavinato
ANTXR1 is one of two cell surface receptors mediating the uptake of the anthrax toxin into cells. Despite substantial research on its role in anthrax poisoning and a proposed function as a collagen receptor, ANTXR1's physiological functions remain largely undefined. Pathogenic variants in ANTXR1 lead to the rare GAPO syndrome, named for its four primary features: Growth retardation, Alopecia, Pseudoanodontia, and Optic atrophy. The disease is also associated with a complex range of other phenotypes impacting the cardiovascular, skeletal, pulmonary and nervous systems...
April 23, 2024: Scientific Reports
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JOURNAL ARTICLE
Yushi Suzuki, Hiro Hasegawa, Takashi Mori, Koichi Teramura, Yuichiro Tsukada, Takeshi Sasaki, Motohiro Kojima, Masaaki Ito
BACKGROUND: An unexpectedly large number of patients experienced local recurrence with transanal total mesorectal excision in Norway. This appears to be associated with cancer cell spillage during surgery. OBJECTIVE: To investigate the surgical field cytology during transanal total mesorectal excision. DESIGN: This was a prospective cohort study. SETTINGS: This study was conducted at a single center between June and December 2020...
April 23, 2024: Diseases of the Colon and Rectum
#17
JOURNAL ARTICLE
Jo E Lewis, Danae Nuzzaci, Paula-Peace James-Okoro, Mireia Montaner, Elisabeth O'Flaherty Rottenberger, Tamana Darwish, Marito Hayashi, Stephen D Liberles, David Hornigold, Jacqueline Naylor, David Baker, Fiona M Gribble, Frank Reimann
OBJECTIVE: Glucose dependent insulinotropic polypeptide (GIP) is well established as an incretin hormone, boosting glucose-dependent insulin secretion. However, whilst anorectic actions of its sister-incretin glucagon-like peptide-1 (GLP-1) are well established, a physiological role for GIP in appetite regulation is controversial, despite the superior weight loss seen in preclinical models and humans with GLP-1/GIP dual receptor agonists compared with GLP-1R agonism alone. METHODS: We generated a mouse model in which GIP expressing K-cells can be activated through hM3Dq Designer Receptor Activated by Designer Drugs (DREADD, GIP-Dq) to explore physiological actions of intestinally-released GIP...
April 21, 2024: Molecular Metabolism
#18
JOURNAL ARTICLE
Mariko Takahashi, Harrison B Chong, Siwen Zhang, Tzu-Yi Yang, Matthew J Lazarov, Stefan Harry, Michelle Maynard, Brendan Hilbert, Ryan D White, Heather E Murrey, Chih-Chiang Tsou, Kira Vordermark, Jonathan Assaad, Magdy Gohar, Benedikt R Dürr, Marianne Richter, Himani Patel, Gregory Kryukov, Natasja Brooijmans, Aliyu Sidi Omar Alghali, Karla Rubio, Antonio Villanueva, Junbing Zhang, Maolin Ge, Farah Makram, Hanna Griesshaber, Drew Harrison, Ann-Sophie Koglin, Samuel Ojeda, Barbara Karakyriakou, Alexander Healy, George Popoola, Inbal Rachmin, Neha Khandelwal, Jason R Neil, Pei-Chieh Tien, Nicholas Chen, Tobias Hosp, Sanne van den Ouweland, Toshiro Hara, Lillian Bussema, Rui Dong, Lei Shi, Martin Q Rasmussen, Ana Carolina Domingues, Aleigha Lawless, Jacy Fang, Satoshi Yoda, Linh Phuong Nguyen, Sarah Marie Reeves, Farrah Nicole Wakefield, Adam Acker, Sarah Elizabeth Clark, Taronish Dubash, John Kastanos, Eugene Oh, David E Fisher, Shyamala Maheswaran, Daniel A Haber, Genevieve M Boland, Moshe Sade-Feldman, Russell W Jenkins, Aaron N Hata, Nabeel M Bardeesy, Mario L Suvà, Brent R Martin, Brian B Liau, Christopher J Ott, Miguel N Rivera, Michael S Lawrence, Liron Bar-Peled
Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed "DrugMap," an atlas of cysteine ligandability compiled across 416 cancer cell lines. We unexpectedly find that cysteine ligandability varies across cancer cell lines, and we attribute this to differences in cellular redox states, protein conformational changes, and genetic mutations...
April 17, 2024: Cell
#19
JOURNAL ARTICLE
Ravy K Vajravelu, Amy R Byerly, Robert Feldman, Scott D Rothenberger, Robert E Schoen, Walid F Gellad, James D Lewis
BACKGROUND: Active surveillance pharmacovigilance is an emerging approach to identify medications with unanticipated effects. We previously developed a framework called pharmacopeia-wide association studies (PharmWAS) that limits false positive medication associations through high-dimensional confounding adjustment and set enrichment. We aimed to assess the transportability and generalizability of the PharmWAS framework by using medical claims data to reproduce known medication associations with Clostridioides difficile infection (CDI) or gastrointestinal bleeding (GIB)...
April 22, 2024: EBioMedicine
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JOURNAL ARTICLE
Islam A Abdelhakim, Yushi Futamura, Yukihiro Asami, Hideaki Hanaki, Naoko Kito, Sachiko Masuda, Arisa Shibata, Atsuya Muranaka, Hiroyuki Koshino, Ken Shirasu, Hiroyuki Osada, Jun Ishikawa, Shunji Takahashi
Actinomycetes are prolific producers of natural products, particularly antibiotics. However, a significant proportion of its biosynthetic gene clusters (BGCs) remain silent under typical laboratory conditions. This limits the effectiveness of conventional isolation methods for the discovery of novel natural products. Genetic interventions targeting the activation of silent gene clusters are necessary to address this challenge. Streptomyces antibiotic regulatory proteins (SARPs) act as cluster-specific activators and can be used to target silent BGCs for the discovery of new antibiotics...
April 23, 2024: Journal of Natural Products
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