keyword
MENU ▼
Read by QxMD icon Read
search

Unexpected

keyword
https://www.readbyqxmd.com/read/29677664/age-induced-changes-in-the-lower-limb-muscle-activities-during-uphill-walking-at-steep-grades
#1
Sonja Th Kwee-Meier, Alexander Mertens, Sabina Jeschke
BACKGROUND: Uphill walking is particularly challenging for elderly persons. However, there is a lack of age-differentiated studies investigating the underlying differences in muscle activation when walking on sloped surfaces. These studies are needed, e.g., for planning of evacuations of large modern cruise ships with long walking distances on often inclined surfaces. METHODS: An age-differentiated, gender-balanced study with 26 young (20-30 years) and 26 elderly people (60-77 years) was therefore conducted, investigating uphill walking at 7° and at 14° contrasted to level walking on a treadmill...
April 12, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29677593/lucky-or-clever-from-expectations-to-responsibility-judgments
#2
Tobias Gerstenberg, Tomer D Ullman, Jonas Nagel, Max Kleiman-Weiner, David A Lagnado, Joshua B Tenenbaum
How do people hold others responsible for the consequences of their actions? We propose a computational model that attributes responsibility as a function of what the observed action reveals about the person, and the causal role that the person's action played in bringing about the outcome. The model first infers what type of person someone is from having observed their action. It then compares a prior expectation of how a person would behave with a posterior expectation after having observed the person's action...
April 17, 2018: Cognition
https://www.readbyqxmd.com/read/29677383/effects-of-inhibitors-on-hsp90-s-conformational-dynamics-cochaperone-and-client-interactions
#3
Sonja Schmid, Markus Goetz, Thorsten Hugel
The molecular chaperone and heat-shock protein Hsp90 has become a central target in anti-cancer therapy. Nevertheless, the effect of Hsp90 inhibition is still not understood at the molecular level, preventing a truly rational drug design. Here we report on the effect of the most prominent drug candidates, namely radicicol, geldanamycin, derivatives of purine and novobiocin, on Hsp90's characteristic conformational dynamics and the binding of three interaction partners. Unexpectedly, the global opening and closing transitions are hardly affected by Hsp90 inhibitors...
April 20, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29677063/the-anesthesia-perioperative-call-for-help-experience-at-a-quaternary-pediatric-medical-center-analysis-of-67-564-anesthesia-encounters
#4
Bistra G Vlassakova, Sean M Sinnott, Nissa Askins, Matthew X Callahan, Izabela C Leahy, David Zurakowski, Paul R Hickey, Joseph P Cravero
BACKGROUND: During the past several decades, anesthesia has become increasingly safe. Truly major adverse events are rare, and anesthesia quality researchers have instituted programs to evaluate "near miss" or less critical adverse events to evaluate the safety of anesthesia delivery. In this study, we aimed to evaluate calls for emergency help in our institution as a surrogate for pending critical events. We hypothesized that calls would be more common in patients with high American Society of Anesthesiologists (ASA) physical status, history of prematurity, and children with recent respiratory illness compared to those without these characteristics...
April 17, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29676821/dynamic-covalent-chemistry-under-high-pressure-a-new-route-to-disulfide-metathesis
#5
Szymon Sobczak, Wojciech Drożdż, Giulio Lampronti, Anna Belenguer, Andrzej Katrusiak, Artur Ryszard Stefankiewicz
We describe here for the first time the application of combined pressure and temperature stimuli in disulfide metathesis reactions. In the system studied, above a pressure of 0.2 GPa equimolar amounts of symmetric disulfides bis 4-chlorophenyl disulfide [(4-ClPhS)2] and bis 2-nitrophenyl disulfide [(2-NO2PhS)2] react to give the heterodimeric product 4-ClPhSSPh2-NO2. In contrast to experiments conducted in solution at atmospheric pressure or in mechanochemical experiments under ball-mill grinding conditions, there is no necessity to use a base or thiolate anion as a catalyst for the exchange reaction under investigated conditions...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29676776/gene-expression-analysis-of-neuropeptides-in-oral-mucosa-during-periodontal-disease-in-nonhuman-primates
#6
John Ferrin, Jeffrey L Ebersole, Sreenatha Kirakodu, David Jensen, Ahmad Al-Attar, Rebecca Peyyala, M John Novak, Dolph Dawson, Mohanad Al-Sabbagh, Arnold J Stromberg, Luis Orraca, Janis Gonzalez-Martinez, Armando Burgos, Octavio A Gonzalez
BACKGROUND: Neuropeptides (NPs) are innate pivotal regulators of the immunoinflammatory response. Nevertheless, their role in the pathogenesis of the periodontal disease remains unknown. We determined changes in gene expression of 10 NPs and 16 NP receptors (NPRs) coincident with the initiation, progression and resolution of periodontitis. METHODS: The ligature-induced periodontitis model was used in rhesus monkeys (n = 18). Gingival tissue samples were taken at baseline pre-ligature, 2 weeks and 1 month (Initiation), and 3 months (Progression) post-ligation...
April 20, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29676714/-does-ovarian-cancer-start-in-the-fallopian-tubes-possible-implications-for-preventive-adnexal-removal
#7
M P Steenbeek, J Bulten, N Hoogerbrugge, L F A G Massuger, J M A Pijnenborg, J A de Hullu
BACKGROUND: Recent insights in high-grade serous ovarian cancer development are pointing to the fallopian tubes as likely place of origin and not the ovaries themselves. This may have consequences for patients with increased risk of ovarian cancer. Adnexal removal is currently recommended for this patient group at an age of 35-45, which leads to premature menopause. CASE DESCRIPTION: In a 55-year-old woman with a BRCA1 germ line mutation, a high-grade serous carcinoma was unexpectedly diagnosed in both fallopian tubes during preventive adnexal removal...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29676664/neural-processing-of-gendered-information-is-more-robustly-associated-with-mothers-gendered-communication-with-children-than-mothers-implicit-and-explicit-gender-stereotypes
#8
Joyce J Endendijk, Hannah Spencer, Peter A Bos, Belle Derks
Processes like gender socialization (the ways in which parents convey information to their children about how girls and boys should behave) often happen unconsciously and might therefore be studied best with neuroscientific measures. We examined whether neural processing of gender-stereotype-congruent and incongruent information is more robustly related to mothers' gendered socialization of their child than mothers' implicit and explicit gender stereotypes. To this end, we examined event-related potentials (ERPs) of mothers (N = 35) completing an implicit gender-stereotype task and mothers' gender stereotypes in relation to observed gendered communication with their child (2-6 years old) in a naturalistic picture-book-reading setting...
April 20, 2018: Social Neuroscience
https://www.readbyqxmd.com/read/29676514/differential-effects-of-offspring-and-maternal-inbreeding-on-egg-laying-and-offspring-performance-in-the-burying-beetle-nicrophorus-vespilloides
#9
Lucy E Ford, Kirsten J Henderson, Per T Smiseth
We investigate the effect of offspring and maternal inbreeding on maternal and offspring traits associated with early offspring fitness in the burying beetle Nicrophorus vespilloides. We conducted two experiments. In the first experiment, we manipulated maternal inbreeding only (keeping offspring outbred) by generating mothers that were outbred, moderately inbred or highly inbred. Meanwhile, in the second experiment, we manipulated offspring inbreeding only (keeping females outbred) by generating offspring that were outbred, moderately inbred or highly inbred...
April 20, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29676377/expect-the-unexpected-loss-of-surface-cd3-on-flow-cytometry-in-hepatosplenic-t-cell-lymphoma-an-eye-opener
#10
Richa Chauhan, Seema Tyagi, Sumeet Mirgh, Priyanka Mishra, Tulika Seth, Manoranjan Mahapatra, Haraprasad Pati, Renu Saxena
Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3- on immunophenotyping by flow cytometry...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676331/cervicofacial-emphysema-following-unilateral-external-dacryocystorhinostomies-a-case-report
#11
Ziya Akingol, Safak Karslioglu, Didem Serin
Cervicofacial emphysema (CFE), mostly seen after trauma or dental procedures, is an unexpected, extremely rare condition after uncomplicated dacryocystorhinostomy (DCR). It may be misdiagnosed as angioedema or necrotizing fasciitis. In this article, we present the case of a 40-year-old female with CFE twice after uncomplicated unilateral DCR for left and right sides on different operative days. CFE was confirmed by computed tomography, demonstrating extensive air within subcutaneous tissues of the face, neck, and orbital cavity...
May 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29676287/electrophysiological-correlates-of-neurodegeneration-in-motor-and-non-motor-brain-regions-in-amyotrophic-lateral-sclerosis-implications-for-brain-computer-interfacing
#12
Philipp Kellmeyer, Moritz Grosse-Wentrup, Andreas Schulze-Bonhage, Ulf Ziemann, Tonio Ball
For patients with amyotrophic lateral sclerosis (ALS) who are suffering from severe communication or motor problems, brain-computer interfaces (BCIs) can improve the quality of life and patient autonomy. However, current BCI systems are not as widely used as their potential and patient demand would let assume. This underutilization is a result of technological as well as user-based limitations but also of the comparatively poor performance of currently existing BCIs in patients with late-stage ALS, particularly in the locked-in state...
April 20, 2018: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29676164/the-intimate-partner-flooding-scale
#13
Heather M Foran, Michael Lorber, Jill Malik, Richard E Heyman, Amy M Smith Slep
Dysfunctional conflict resolution behaviors in couples have been long recognized as markers of relationship maladjustment and are, consequently, frequent targets of couple therapy. The process of flooding may play a role. Flooding is the subjective sense of being overwhelmed by the partner's negative affect, which is perceived as unexpected and intense, and feeling as though one's information processing is impaired. It has been theorized that flooding is so aversive as to lead to maladaptive conflict behaviors (e...
April 1, 2018: Assessment
https://www.readbyqxmd.com/read/29675618/seq-ing-answers-uncovering-the-unexpected-in-global-gene-regulation
#14
REVIEW
George Maxwell Otto, Gloria Ann Brar
The development of techniques for measuring gene expression globally has greatly expanded our understanding of gene regulatory mechanisms in depth and scale. We can now quantify every intermediate and transition in the canonical pathway of gene expression-from DNA to mRNA to protein-genome-wide. Employing such measurements in parallel can produce rich datasets, but extracting the most information requires careful experimental design and analysis. Here, we argue for the value of genome-wide studies that measure multiple outputs of gene expression over many timepoints during the course of a natural developmental process...
April 19, 2018: Current Genetics
https://www.readbyqxmd.com/read/29675435/serum-levels-of-interleukin-13-increase-in-subjects-with-insulin-resistance-but-do-not-correlate-with-markers-of-low-grade-systemic-inflammation
#15
Camilo P Martínez-Reyes, Angélica Y Gómez-Arauz, Israel Torres-Castro, Aarón N Manjarrez-Reyna, León F Palomera, Alfonso Olivos-García, Edith Mendoza-Tenorio, Gabriela A Sánchez-Medina, Sergio Islas-Andrade, Guillermo Melendez-Mier, Galileo Escobedo
Experimental evidence in mice suggests a role for interleukin- (IL-) 13 in insulin resistance and low-grade systemic inflammation. However, IL-13 serum levels have not been assessed in subjects with insulin resistance, and associations of IL-13 with parameters of low-grade systemic inflammation are still unknown. Our main goal was to examine the systemic levels of IL-13 in patients with insulin resistance, while also studying the relationship of IL-13 with anthropometric, metabolic, and low-grade systemic inflammatory markers...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29674984/rhythm-and-melody-tasks-for-school-aged-children-with-and-without-musical-training-age-equivalent-scores-and-reliability
#16
Kierla Ireland, Averil Parker, Nicholas Foster, Virginia Penhune
Measuring musical abilities in childhood can be challenging. When music training and maturation occur simultaneously, it is difficult to separate the effects of specific experience from age-based changes in cognitive and motor abilities. The goal of this study was to develop age-equivalent scores for two measures of musical ability that could be reliably used with school-aged children (7-13) with and without musical training. The children's Rhythm Synchronization Task (c-RST) and the children's Melody Discrimination Task (c-MDT) were adapted from adult tasks developed and used in our laboratories...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674976/neocytolysis-how-to-get-rid-of-the-extra-erythrocytes-formed-by-stress-erythropoiesis-upon-descent-from-high-altitude
#17
REVIEW
Heimo Mairbäurl
Neocytolysis is the selective destruction of those erythrocytes that had been formed during stress-erythropoiesis in hypoxia in order to increase the oxygen transport capacity of blood. Neocytolysis likely aims at decreasing this excess amount of erythrocytes and hemoglobin (Hb) when it is not required anymore and to decrease blood viscosity. Neocytolysis seems to occur upon descent from high altitude. Similar processes seem to occur in microgravity, and are also discussed to mediate the replacement of erythrocytes containing fetal hemoglobin (HbF) with those having adult hemoglobin (HbA) after birth...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674810/rotary-science-and-its-impact-on-instrument-separation-a-focused-review
#18
REVIEW
Sandhya Anand Khasnis, Prem Prakash Kar, Apoorva Kamal, Jayaprakash D Patil
Efficient endodontic treatment demands thorough debridement of the root canal system with minimal procedural errors. The inherent weakness of nickel-titanium alloys is their unexpected breakage. Modifications in the design, manufacturing, thermomechanical and surface treatment of alloys and advancements in movement kinetics have shown to improve the fatigue properties of the alloys, reducing the incidence of separation. This review enlightens the impact of these factors on fatigue properties of the alloy.
March 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29674788/a-new-genus-and-species-of-vespertilionid-bat-from-the-indomalayan-region
#19
Manuel Ruedi, Judith L Eger, Burton K Lim, Gábor Csorba
Bats belonging to the subfamily Vespertilioninae are diverse and cosmopolitan, but their systematic arrangement remains a challenge. Previous molecular surveys suggested new and unexpected relationships of some members compared to more traditional, morphology-based classifications, and revealed the existence of taxonomically undefined lineages. We describe here a new genus and species corresponding to an enigmatic lineage that was previously identified within the genus Eptesicus in the Indomalayan Region. Phylogenetic reconstructions based on mitochondrial and nuclear genes relate the new taxon to Tylonycteris and Philetor , and show that specimens associated with this new genus represent 2 genetically distinct species...
February 1, 2018: Journal of Mammalogy
https://www.readbyqxmd.com/read/29674755/characterizing-metal-binding-sites-in-proteins-with-x-ray-crystallography
#20
Katarzyna B Handing, Ewa Niedzialkowska, Ivan G Shabalin, Misty L Kuhn, Heping Zheng, Wladek Minor
Metals have crucial roles in many physiological, pathological, toxicological, pharmaceutical, and diagnostic processes. Proper handling of metal-containing macromolecule samples for structural studies is not trivial, and failure to handle them properly is often a source of irreproducibility caused by issues such as pH changes, incorporation of unexpected metals, or oxidization/reduction of the metal. This protocol outlines the guidelines and best practices for characterizing metal-binding sites in protein structures and alerts experimenters to potential pitfalls during the preparation and handling of metal-containing protein samples for X-ray crystallography studies...
May 2018: Nature Protocols
keyword
keyword
63005
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"