Zhongyuan Cai, Lingling Jiang, Yingzi Cao, Shengxiang Fu, Shasha Wang, Yuting Jiang, Haojie Gu, Na Li, Xiaomin Fu, Shimin Tang, Jiang Zhu, Weidong Cao, Lei Zhong, Zhuzhong Cheng, Chunchao Xia, Su Lui, Bin Song, Qiyong Gong, Hua Ai
Effective vascular and hepatic enhancement and better safety are the key drivers for exploring gadolinium-free hepatobiliary contrast agents. Herein, a facile strategy proposes that the high lipophilicity may be favorable to enhancing sequentially vascular and hepatobiliary signal intensity based on the structure-activity relationship that both hepatic uptake and interaction with serum albumins partly depend on lipophilicity. Therefore, 11 newly synthesized derivatives of manganese o -phenylenediamine- N , N , N ', N '-tetraacetic acid (MnLs) were evaluated as vascular and hepatobiliary agents...
March 7, 2024: Journal of Medicinal Chemistry