keyword
https://read.qxmd.com/read/38496846/flavonoids-a-treasure-house-of-prospective-pharmacological-potentials
#1
REVIEW
Hasin Hasnat, Suriya Akter Shompa, Md Mirazul Islam, Safaet Alam, Fahmida Tasnim Richi, Nazim Uddin Emon, Sania Ashrafi, Nazim Uddin Ahmed, Md Nafees Rahman Chowdhury, Nour Fatema, Md Sakhawat Hossain, Avoy Ghosh, Firoj Ahmed
Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these natural substances are renowned, and initiatives are being taken to extract the flavonoids. Apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin are the seven most common compounds belonging to this class. A thorough analysis of bibliographic records from reliable sources including Google Scholar, Web of Science, PubMed, ScienceDirect, MEDLINE, and others was done to learn more about the biological activities of these flavonoids...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38494890/dynamic-nonreversibility-view-of-intrinsic-brain-organization-and-brain-dynamic-analysis-of-repetitive-transcranial-magnitude-stimulation
#2
JOURNAL ARTICLE
Liming Fan, Youjun Li, Xingjian Zhao, Zi-Gang Huang, Tian Liu, Jue Wang
Intrinsic neural activities are characterized as endless spontaneous fluctuation over multiple time scales. However, how the intrinsic brain organization changes over time under local perturbation remains an open question. By means of statistical physics, we proposed an approach to capture whole-brain dynamics based on estimating time-varying nonreversibility and k-means clustering of dynamic varying nonreversibility patterns. We first used synthetic fMRI to investigate the effects of window parameters on the temporal variability of varying nonreversibility...
March 1, 2024: Cerebral Cortex
https://read.qxmd.com/read/38492785/development-of-a-suitable-vibration-pad-for-renal-mr-elastography
#3
JOURNAL ARTICLE
Yoshito Ishihara, Tomokazu Numano, Daiki Ito, Hisao Nishijo, Koichi Takamoto, Jo Kikuchi, Shota Konuma, Hiromu Oka
The aim of this study was to develop a vibration pad suitable for renal MR elastography (MRE). Chronic kidney disease (CKD) is a progressive condition affecting >800 million people worldwide. Renal fibrosis is a common pathological feature of CKD that causes fibrotic regions to be much stiffer than those in normal renal tissues. Therefore, MRE can be used to diagnose CKD because it can image organ stiffness. In MRE, the shear modulus is obtained from the wavelength of the shear waves. Therefore, it is highly important to propagate shear waves with sufficient vibration strength in the tissue...
March 14, 2024: Magnetic Resonance Imaging
https://read.qxmd.com/read/38490564/optimizing-crispr-cas9-approaches-in-the-polymorphic-tunicate-ciona-intestinalis
#4
JOURNAL ARTICLE
Alessandro Pennati, Miloš Jakobi, Fan Zeng, Luca Ciampa, Ute Rothbächer
CRISPR/Cas9 became a powerful tool for genetic engineering and in vivo knockout also in the invertebrate chordate Ciona intestinalis. Ciona (ascidians, tunicates) is an important model organism because it shares developmental features with the vertebrates, considered the sister group of tunicates, and offers outstanding experimental advantages: a compact genome and an invariant developmental cell lineage that, combined with electroporation mediated transgenesis allows for precise and cell type specific targeting in vivo...
March 13, 2024: Developmental Biology
https://read.qxmd.com/read/38490419/mechanism-and-ecological-environmental-risk-assessment-of-peroxymonosulfate-for-the-treatment-of-heavy-metals-in-soil
#5
JOURNAL ARTICLE
Lai-Min Zhang, Lu-Lu Long, Qi-Ran Zhu, Chao Chen, Min Xu, Jun Wu, Gang Yang
Oxidation technologies based on peroxymonosulfate (PMS) have been effectively used for the remediation of soil organic pollutants due to their high efficiency. However, the effects of advanced PMS-based oxidation technologies on other soil pollutants, such as heavy metals, remain unknown. In this study, changes in the form of heavy metals in soil after using PMS and the risk of pollution to the ecological environment were investigated. Furthermore, two risk assessment methods, the mung bean germination toxicity test and groundwater leaching soil column test, were employed to evaluate the soil before and after PMS treatment...
March 13, 2024: Science of the Total Environment
https://read.qxmd.com/read/38490078/extending-the-grading-of-recommendations-assessment-development-and-evaluation-grade-in-traditional-chinese-medicine-tcm-the-grade-tcm
#6
JOURNAL ARTICLE
Qin-Wei Fu, Yang Liu, Shu-Cheng Chen, Lan-Zhi Zhang, Wei-Ting Liu, Zhi-Qing Liu, Ying Liu, Yan Xie, Li Fu, Min Liu, Da-Zheng Zhang, Sha-Sha Yang, Fu-Bin Zhang, He-Yin Huang, Juan Zhong, Kai-Yun Pang, Yong-Na Chen, Ye-Peng Yang, Meng-Lin Dai, Shu-Yun Liu, Shi-Peng Zhang, Feng Xiang, Mi Tang, Pei-Jia Li, Cai-Shan Fang, Qin-Xiu Zhang, Wing-Fai Yeung, Xin-Rong Li
AIM: To extend and form the "Grading of Recommendations Assessment, Development and Evaluation in Traditional Chinese Medicine" (GRADE-TCM). METHODS: Methodologies were systematically reviewed and analyzed concerning evidence-based TCM guidelines worldwide. A survey questionnaire was developed based on the literature review and open-end expert interviews. Then, we performed expert consensus, discussion meeting, opinion collection, external examination, and the GRADE-TCM was formed eventually...
February 27, 2024: Phytomedicine
https://read.qxmd.com/read/38487252/acppfel-explainable-deep-ensemble-learning-for-anticancer-peptides-prediction-based-on-feature-optimization
#7
JOURNAL ARTICLE
Mingyou Liu, Tao Wu, Xue Li, Yingxue Zhu, Sen Chen, Jian Huang, Fengfeng Zhou, Hongmei Liu
Background : Cancer is a significant global health problem that continues to cause a high number of deaths worldwide. Traditional cancer treatments often come with risks that can compromise the functionality of vital organs. As a potential alternative to these conventional therapies, Anticancer peptides (ACPs) have garnered attention for their small size, high specificity, and reduced toxicity, making them as a promising option for cancer treatments. Methods : However, the process of identifying effective ACPs through wet-lab screening experiments is time-consuming and requires a lot of labor...
2024: Frontiers in Genetics
https://read.qxmd.com/read/38483496/biochar-from-co-pyrolysis-of-biological-sludge-and-sawdust-in-comparison-with-the-conventional-filling-media-of-vertical-flow-constructed-wetlands-for-the-treatment-of-domestic-textile-wastewater
#8
JOURNAL ARTICLE
Mariem Ayadi, Davide Passaseo, Giulia Bonaccorso, Michelangelo Fichera, Lapo Renai, Lorenzo Venturini, Ilaria Colzi, Donatella Fibbi, Massimo Del Bubba
A biochar from co-pyrolysis of a mixture of sawdust and biological sludge (70/30, w/w), providing a high environmental compatibility in terms of water leachable polycyclic aromatic hydrocarbons and inorganic elements, together with a remarkable surface area (389 m2 /g), was integrated into laboratory-scale vertical-flow constructed wetlands (VF-CWs), planted with Phragmites australis and unplanted. Biochar-filled VF-CWs have been tested for 8 months for the refining of effluents from the tertiary clariflocculation stage of a wastewater treatment plant operating in a mixed domestic-industrial textile context, in comparison with systems filled with gravel...
March 2024: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://read.qxmd.com/read/38481114/the-combination-of-bioactive-herbal-compounds-with-biomaterials-for-regenerative-medicine
#9
JOURNAL ARTICLE
Guoying Zhou, Ruojiao Xu, Thomas Groth, Yanying Wang, Xingyu Yuan, Hua Ye, Xiaobing Dou
Regenerative medicine aims to restore the function of diseased or damaged tissues and organs by cell therapy, gene therapy, and tissue engineering, along with the adjunctive application of bioactive molecules. Traditional bioactive molecules such as growth factors and cytokines have shown great potential in regulation of cellular and tissue behavior, but have the disadvantages of limited source, high cost, short half-life, and side effects. In recent years, herbal compounds extracted from natural plants/herbs have gained increasing attention...
March 13, 2024: Tissue Engineering. Part B, Reviews
https://read.qxmd.com/read/38480482/enantioselective-sulfonimidamide-acylation-via-a-cinchona-alkaloid-catalyzed-desymmetrization-scope-data-science-and-mechanistic-investigation
#10
JOURNAL ARTICLE
Brittany C Haas, Ngiap-Kie Lim, Janis Jermaks, Eden Gaster, Melody C Guo, Thomas C Malig, Jacob Werth, Haiming Zhang, F Dean Toste, Francis Gosselin, Scott J Miller, Matthew S Sigman
Methods to access chiral sulfur(VI) pharmacophores are of interest in medicinal and synthetic chemistry. We report the desymmetrization of unprotected sulfonimidamides via asymmetric acylation with a cinchona-phosphinate catalyst. The desired products are formed in excellent yield and enantioselectivity with no observed bis-acylation. A data-science-driven approach to substrate scope evaluation was coupled to high throughput experimentation (HTE) to facilitate statistical modeling in order to inform mechanistic studies...
March 13, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38478118/validation-of-the-russian-version-of-the-prolapse-quality-of-life-questionnaire-and-its-application-to-assess-the-impact-of-pelvic-organ-prolapse-on-quality-of-life-and-the-effect-of-treatment-in-women-undergoing-reconstructive-surgery
#11
JOURNAL ARTICLE
Rustam Shakhaliev, Nikita Kubin, Tatiana Nikitina, Tatiana Ionova, Alex Digesu, Dmitry Shkarupa
INTRODUCTION AND HYPOTHESIS: The objective was to validate the translated Russian version of the prolapse quality-of-life (P-QoL) questionnaire and test its applicability to assess the impact of pelvic organ prolapse (POP) on QoL and the effect of treatment in women undergoing reconstructive surgery. METHODS: Following a forward- and back-translation of the original English P-QOL questionnaire into Russian, the translated questionnaire was reviewed by a group of patients as well as an expert panel...
March 13, 2024: International Urogynecology Journal
https://read.qxmd.com/read/38477326/solid-waste-recycled-cuo-c-3-n-4-s-scheme-heterojunctions-for-efficient-photocatalytic-antibiotic-degradation
#12
JOURNAL ARTICLE
Jiawen Liu, Jiahui Lin, Kai Yi, Fangyan Liu, Feng Gao, Mengye Wang, Feng Huang
With the increasing severity of antibiotic pollution, the development of effective green photocatalysts for the degradation of organic pollutants in water has attracted extensive attention. Herein, we have prepared CuO/C3 N4 S-scheme heterogeneous photocatalysts via recycling Cu resources from Cu-containing electroplating sludges. By mediating the acid leaching process, copper in electroplating sludges was dissolved selectively, while other metal species were retained in the residues. The CuO/C3 N4 S-scheme heterojunction not only effectively suppressed the recombination of photogenerated charge carriers of C3 N4 , but also preserved the strong reducing electrons of C3 N4 and the strong oxidizing holes of CuO, retaining the outstanding redox ability of CuO/C3 N4 ...
March 13, 2024: Nanoscale
https://read.qxmd.com/read/38474552/study-of-bitespiramycin-distribution-in-rats-and-cerebrospinal-fluid-of-patients-by-a-sensitive-lc-ms-ms-method-with-rapid-sample-preparation
#13
JOURNAL ARTICLE
Yujie Zhang, Jingjie Cao, Jiahan Su, Tingting He, Qianru Wang, Feng Wei, Xin Guo, Qibing Mei, Jing Zeng
Bitespiramycin, has been shown to have a therapeutic effect against respiratory tract inflammation, including a potential effect against COVID-19. A current clinical trial in China showed that bitespiramycin was an effective treatment for severe pneumonia and intracranial infection. However, there is lack of an analytical method to elucidate the distribution of bitespiramycin. In this study, a highly sensitive, rapid and reliable UPLC-MS/MS method was developed to comprehensively characterize the bitespiramycin distribution in various bio-samples, which is significantly improved upon the published work...
February 28, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38470189/decorating-pd-au-nanodots-around-porous-in-2-o-3-nanocubes-for-tolerant-h-2-sensing-against-switching-response-and-h-2-s-poisoning
#14
JOURNAL ARTICLE
Xinhua Zhao, Lingling Du, Xiaxia Xing, Zhenxu Li, Yingying Tian, Xiaoyu Chen, Xiaoyan Lang, Huigang Liu, Dachi Yang
With the recently-booming hydrogen (H2 ) economy by green H2 as the energy carriers and the newly-emerged exhaled diagnosis by human organ-metabolized H2 as a biomarker, H2 sensing is simultaneously required with fast response, low detection limit, and tolerant stability against humidity, switching, and poisoning. Here, reliable H2 sensing has been developed by utilizing indium oxide nanocubes decorated with palladium and gold nanodots (Pd-Au NDs/In2 O3 NCBs), which have been synthesized by combined hydrothermal reaction, annealing, and chemical bath deposition...
March 12, 2024: Small
https://read.qxmd.com/read/38470126/comparison-of-the-performance-of-multiple-whole-genome-sequence-based-tools-for-the-identification-of-bacillus-cereus-sensu-stricto-biovar-thuringiensis
#15
JOURNAL ARTICLE
Taejung Chung, Abimel Salazar, Grant Harm, Sophia Johler, Laura M Carroll, Jasna Kovac
The Bacillus cereus sensu stricto ( s.s .) species comprises strains of biovar Thuringiensis ( Bt ) known for their bioinsecticidal activity, as well as strains with foodborne pathogenic potential. Bt strains are identified (i) based on the production of insecticidal crystal proteins, also known as Bt toxins, or (ii) based on the presence of cry , cyt , and vip genes, which encode Bt toxins. Multiple bioinformatics tools have been developed for the detection of crystal protein-encoding genes based on whole-genome sequencing (WGS) data...
March 12, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38468737/cypermethrin-an-emerging-pollutant-and-its-adverse-effect-on-fish-health-and-some-preventive-approach-a-review
#16
REVIEW
Vishakha Sinha, Shobha Shrivastava
Pesticides are substance that are used to manage pests, such as aquatic weeds, plant diseases and insects. It has been shown that these substances are highly hazardous to fish as well as other organisms that are part of the food chain. The presence of cypermethrin in food and groundwater has raised environmental concerns, there is a need to develop economical, rapid, and reliable techniques that can be used for field applications Many studies have shown that Cypermethrin (CYP) can cause toxic effect in various animals including fishes...
March 2024: Indian Journal of Microbiology
https://read.qxmd.com/read/38466323/fabrication-of-nico-bimetallic-mof-films-on-3d-foam-with-assistance-of-atomic-layer-deposition-for-non-invasive-lactic-acid-sensing
#17
JOURNAL ARTICLE
Zihan Lu, Xinyi Ke, Zhe Zhao, Jiayuan Huang, Chang Liu, Jinlong Wang, Ruoyan Xu, Yongfeng Mei, Gaoshan Huang
Lactic acid (LA) is an important downstream product of glycolysis in living cells and is abundant in our body fluids, which are strongly associated with diseases. The development of enzyme-free LA sensors with high sensitivity and low consumption remains a challenge. 2D metal-organic frameworks (MOFs) are considered to be promising electrochemical sensing materials and have attracted much attention in recent years. Compared to monometallic MOFs, the construction of bimetallic MOFs (BMOFs) can obtain a larger specific surface area, thereby increasing the exposed active site...
March 11, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38465948/detection-and-isolation-of-campylobacter-spp-from-raw-meat
#18
JOURNAL ARTICLE
Yiping He, Joseph Capobianco, Cheryl M Armstrong, Chin-Yi Chen, Katrina Counihan, Joe Lee, Sue Reed, Shannon Tilman
This article presents a rapid yet robust protocol for isolating Campylobacter spp. from raw meats, specifically focusing on Campylobacter jejuni and Campylobacter coli. The protocol builds upon established methods, ensuring compatibility with the prevailing techniques employed by regulatory bodies such as the Food and Drug Administration (FDA) and the U.S. Department of Agriculture (USDA) in the USA, as well as the International Organization for Standardization (ISO) in Europe. Central to this protocol is collecting a rinsate, which is concentrated and resuspended in Bolton Broth media containing horse blood...
February 23, 2024: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/38462090/non-enzymatic-electrochemical-impedance-sensor-for-selective-detection-of-electro-inactive-organophosphate-pesticides-using-zr-mof-zro-2-mwcnt-ternary-composite
#19
JOURNAL ARTICLE
N Gokila, Yuvaraj Haldorai, P Saravanan, Ramasamy Thangavelu Rajendra Kumar
The existence of multiple pesticide residues in fruits and vegetables constitutes a direct peril to living organisms. Therefore, it is crucial to develop a low-cost screening method for determining organophosphate pesticides (OPPs) in food samples. This study describes the solvothermal synthesis of a ternary composite comprising multi-walled carbon nanotubes (MWCNT), zirconium oxide, and a zirconium-metal-organic framework (Zr-MOF). The ternary composite was characterised using XRD, FESEM, FTIR, and BET. The ternary composite provides a large surface area (1158 m2 /g) compared with the pristine Zr-MOF (868 m2 /g)...
March 8, 2024: Environmental Research
https://read.qxmd.com/read/38461364/in-plane-oxygen-diffusion-measurements-in-polymer-films-using-time-resolved-imaging-of-programmable-luminescent-tags
#20
JOURNAL ARTICLE
Richard Kantelberg, Tim Achenbach, Anton Kirch, Sebastian Reineke
Oxygen diffusion properties in thin polymer films are key parameters in industrial applications from food packaging, over medical encapsulation to organic semiconductor devices and have been continuously investigated in recent decades. The established methods have in common that they require complex pressure-sensitive setups or vacuum technology and usually do not come without surface effects. In contrast, this work provides a low-cost, precise and reliable method to determine the oxygen diffusion coefficient D in bulk polymer films based on tracking the phosphorescent pattern of a programmable luminescent tag over time...
March 9, 2024: Scientific Reports
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