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https://www.readbyqxmd.com/read/27916176/functional-assessment-and-transplantation-of-the-donor-heart-after-circulatory-death
#1
Simon J Messer, Richard G Axell, Simon Colah, Paul A White, Marian Ryan, Aravinda A Page, Barbora Parizkova, Kamen Valchanov, Christopher W White, Darren H Freed, Euan Ashley, John Dunning, Martin Goddard, Jayan Parameshwar, Christopher J Watson, Thomas Krieg, Ayyaz Ali, Steven Tsui, Stephen R Large
BACKGROUND: After a severe shortage of brain-dead donors, the demand for heart transplantation has never been greater. In an attempt to increase organ supply, abdominal and lung transplant programs have turned to the donation after circulatory-determined death (DCD) donor. However, because heart function cannot be assessed after circulatory death, DCD heart transplantation was deemed high risk and never adopted routinely. We report a novel method of functional assessment of the DCD heart resulting in a successful clinical program...
December 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/27913832/general-and-specific-combining-abilities-in-a-maize-zea-mays-l-test-cross-hybrid-panel-relative-importance-of-population-structure-and-genetic-divergence-between-parents
#2
A Larièpe, L Moreau, J Laborde, C Bauland, S Mezmouk, L Décousset, T Mary-Huard, J B Fiévet, A Gallais, P Dubreuil, A Charcosset
General and specific combining abilities of maize hybrids between 288 inbred lines and three tester lines were highly related to population structure and genetic distance inferred from SNP data. Many studies have attempted to provide reliable and quick methods to identify promising parental lines and combinations in hybrid breeding programs. Since the 1950s, maize germplasm has been organized into heterotic groups to facilitate the exploitation of heterosis. Molecular markers have proven efficient tools to address the organization of genetic diversity and the relationship between lines or populations...
December 2, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/27911368/immunohistochemical-analysis-in-the-rat-central-nervous-system-and-peripheral-lymph-node-tissue-sections
#3
Milena Z Adzemovic, Manuel Zeitelhofer, Marianne Leisser, Ulricke Köck, Angela Kury, Tomas Olsson
Immunohistochemistry (IHC) provides highly specific, reliable and attractive protein visualization. Correct performance and interpretation of an IHC-based multicolor labeling is challenging, especially when utilized for assessing interrelations between target proteins in the tissue with a high fat content such as the central nervous system (CNS). Our protocol represents a refinement of the standard immunolabeling technique particularly adjusted for detection of both structural and soluble proteins in the rat CNS and peripheral lymph nodes (LN) affected by neuroinflammation...
November 14, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27909606/knowledge-levels-and-attitudes-of-people-living-in-the-city-centre-of-nev%C3%A5-ehir-on-organ-donation-and-transplantation
#4
Mehmet Akif Yazar, Mehmet Barış Açıkgöz
OBJECTIVE: The purpose of this descriptive study was to determine the knowledge levels and attitudes of people living in Nevşehir on organ donation (OD) and transplantation. METHODS: Data were collected using a questionnaire administered to 414 people residing in Nevşehir between February and May 2016. The primary and secondary endpoints of the present study were to determine the attitudes and knowledge levels of participants on OD and transplantation, respectively...
October 2016: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/27909155/extrapolation-techniques-evaluating-24-hours-of-average-electromagnetic-field-emitted-by-radio-base-station-installations-spectrum-analyzer-measurements-of-lte-and-umts-signals
#5
Stefano Mossetti, Daniela de Bartolo, Ivan Veronese, Marie Claire Cantone, Cristina Cosenza, Elisa Nava
International and national organizations have formulated guidelines establishing limits for occupational and residential electromagnetic field (EMF) exposure at high-frequency fields. Italian legislation fixed 20 V/m as a limit for public protection from exposure to EMFs in the frequency range 0.1 MHz-3 GHz and 6 V/m as a reference level. Recently, the law was changed and the reference level must now be evaluated as the 24-hour average value, instead of the previous highest 6 minutes in a day. The law refers to a technical guide (CEI 211-7/E published in 2013) for the extrapolation techniques that public authorities have to use when assessing exposure for compliance with limits...
December 1, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27909154/towards-a-novel-modular-architecture-for-cern-radiation-monitoring
#6
Hamza Boukabache, Michel Pangallo, Gael Ducos, Nicola Cardines, Antonio Bellotta, Ciarán Toner, Daniel Perrin, Doris Forkel-Wirth
The European Organization for Nuclear Research (CERN) has the legal obligation to protect the public and the people working on its premises from any unjustified exposure to ionising radiation. In this context, radiation monitoring is one of the main concerns of the Radiation Protection Group. After 30 y of reliable service, the ARea CONtroller (ARCON) system is approaching the end of its lifecycle, which raises the need for new, more efficient radiation monitors with a high level of modularity to ensure better maintainability...
November 30, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27907050/when-is-the-brain-dead-living-like-electrophysiological-responses-and-photon-emissions-from-applications-of-neurotransmitters-in-fixed-post-mortem-human-brains
#7
Michael A Persinger, Nicolas Rouleau, Nirosha J Murugan, Lucas W E Tessaro, Justin N Costa
The structure of the post-mortem human brain can be preserved by immersing the organ within a fixative solution. Once the brain is perfused, cellular and histological features are maintained over extended periods of time. However, functions of the human brain are not assumed to be preserved beyond death and subsequent chemical fixation. Here we present a series of experiments which, together, refute this assumption. Instead, we suggest that chemical preservation of brain structure results in some retained functional capacity...
2016: PloS One
https://www.readbyqxmd.com/read/27906655/methodology-considerations-in-phase-mapping-of-human-cardiac-arrhythmias
#8
Ramya Vijayakumar, Sunil K Vasireddi, Phillip S Cuculich, Mitchell N Faddis, Yoram Rudy
BACKGROUND: Phase analysis of cardiac arrhythmias, particularly atrial fibrillation, has gained interest because of the ability to detect organized stable drivers (rotors) and target them for therapy. However, the lack of methodology details in publications on the topic has resulted in ongoing debate over the phase mapping technique. By comparing phase maps and activation maps, we examined advantages and limitations of phase mapping. METHODS AND RESULTS: Seven subjects were enrolled...
November 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27904520/a-diagnostic-one-step-real-time-reverse-transcription-polymerase-chain-reaction-method-for-accurate-detection-of-influenza-virus-type-a
#9
Mohammad Amin Behzadi, Mazyar Ziyaeyan, Abdolvahab Alborzi
INTRODUCTION: Influenza A is known as a public health concern worldwide. In this study, a novel one-step real-time reverse transcription polymerase chain reaction (rtRT-PCR) assay was designed and optimized for the detection of influenza A viruses. MATERIAL AND METHODS: The primers and probe were designed based on the analysis of 90 matrix nucleotide sequence data of influenza type A subtypes from the GenBank database of the National Center for Biotechnology Information (NCBI)...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27897985/a-novel-lighting-oled-panel-design
#10
Enyang Zhang, Weigao Xia, Xiaojian Yan
A novel OLED (organic light emitting diode) lighting panel, which uses a special layout design, can reduce the photolithography cycles and process costs and is more reliable. It only needs two steps of photolithography cycles, which include an ITO (InSnO compound transparent oxide) pattern and insulator pattern. There is no need for the metal bus pattern of the ordinary design. The OLED device structure is a type of red-green-blue (RGB)-stacked emitting layer that has a good color index and greater adjustability, which improves the performance of the device...
November 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27893569/development-and-validation-of-a-novel-motor-cognitive-assessment-strategy-of-compensatory-sit-to-stand-maneuvers-in-people-with-dementia
#11
Christian Werner, Stefanie Wiloth, Nele Christin Lemke, Florian Kronbach, Klaus Hauer
BACKGROUND AND PURPOSE: People with dementia show disease-specific sit-to-stand (STS) movement disorders, which relate to deficits of integrating cognitive aspects of motor processes into motor action organization. During STS training in rehabilitation therapy, compensatory STS movement maneuvers are taught aiming to improve patients' STS ability. Previous clinical STS measures do not address these maneuvers or assess cognitive aspects of their motor action organization. The purpose of this study was to develop and validate a motor-cognitive STS assessment instrument for people with dementia (Assessment of Compensatory Sit-to-Stand Maneuvers in People With Dementia, ACSID)...
November 23, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27891068/can-mouse-imaging-studies-bring-order-to-autism-connectivity-chaos
#12
Adam Liska, Alessandro Gozzi
Functional Magnetic Resonance Imaging (fMRI) has consistently highlighted impaired or aberrant functional connectivity across brain regions of autism spectrum disorder (ASD) patients. However, the manifestation and neural substrates of these alterations are highly heterogeneous and often conflicting. Moreover, their neurobiological underpinnings and etiopathological significance remain largely unknown. A deeper understanding of the complex pathophysiological cascade leading to aberrant connectivity in ASD can greatly benefit from the use of model organisms where individual pathophysiological or phenotypic components of ASD can be recreated and investigated via approaches that are either off limits or confounded by clinical heterogeneity...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27888596/a-study-of-the-readiness-of-hospitals-for-implementation-of-high-reliability-organizations-model-in-tehran-university-of-medical-sciences
#13
Seyed Mohammad Hadi Mousavi, Hossein Dargahi, Sara Mohammadi
Creating a safe of health care system requires the establishment of High Reliability Organizations (HROs), which reduces errors, and increases the level of safety in hospitals. This model focuses on improving reliability through higher process design, building a culture of accreditation, and leveraging human factors. The present study intends to determine the readiness of hospitals for the establishment of HROs model in Tehran University of Medical Sciences from the viewpoint of managers of these hospitals...
October 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27887796/vaccine-strategies-optimising-outcomes
#14
Karin Hardt, Paolo Bonanni, Susan King, Jose Ignacio Santos, Mostafa El-Hodhod, Gregory D Zimet, Scott Preiss
Successful immunisation programmes generally result from high vaccine effectiveness and adequate uptake of vaccines. In the development of new vaccination strategies, the structure and strength of the local healthcare system is a key consideration. In high income countries, existing infrastructures are usually used, while in less developed countries, the capacity for introducing new vaccines may need to be strengthened, particularly for vaccines administered beyond early childhood, such as the measles or human papillomavirus (HPV) vaccine...
November 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27886626/describing-clinical-faculty-experiences-with-patient-safety-and-quality-care-in-acute-care-settings-a-mixed-methods-study
#15
Linda Roney, Catherine Sumpio, Audrey M Beauvais, Eileen R O'Shea
BACKGROUND: A major safety initiative in acute care settings across the United States has been to transform hospitals into High Reliability Organizations. The initiative requires developing cognitive awareness, best practices, and infrastructure so that all healthcare providers including clinical faculty are accountable to deliver quality and safe care. OBJECTIVE: To describe the experience of baccalaureate clinical nursing faculty concerning safety and near miss events, in acute care hospital settings...
November 18, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27885836/texture-analysis-of-medical-images-for-radiotherapy-applications
#16
Elisa Scalco, Giovanna Rizzo
The high-throughput extraction of quantitative information from medical images, known as radiomics, has grown in interest due to the current necessity of quantitatively characterise tumour heterogeneity. In this context, texture analysis, consisting of a variety of mathematical techniques able to describe the grey-level patterns of an image, plays an important role in assessing the spatial organisation of different tissues and organs. For these reasons, the potentiality of texture analysis in the context of radiotherapy has been widely investigated in several studies, especially for the prediction of the treatment response of tumour and normal tissues...
November 25, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27884153/performance-evaluation-of-the-touchscreen-based-muse%C3%A2-auto-cd4-cd4-single-platform-system-for-cd4-t-cell-numeration-in-absolute-number-and-in-percentage-using-blood-samples-from-children-and-adult-patients-living-in-the-central-african-republic
#17
Christian Diamant Mossoro-Kpinde, André Kouabosso, Ralph-Sydney Mboumba Bouassa, Jean De Dieu Longo, Edouard Kokanzo, Rosine Féissona, Gérard Grésenguet, Laurent Bélec
BACKGROUND: The new microcapillary and fluorescence-based EC IVD-qualified Muse™ Auto CD4/CD4% single-platform assay (EMD Millipore Corporation, Merck Life Sciences, KGaA, Darmstadt, Germany) for CD4 T cell numeration in absolute number and in percentage was evaluated using Central African patients' samples compared against the reference EC IVD-qualified BD FACSCount (Becton-Dickinson, USA) flow cytometer. METHODS: EDTA-blood samples from 124 adults, 10 adolescents, 13 children and 3 infants were tested in parallel at 2 reference laboratories in Bangui...
November 25, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27876893/highly-bendable-in-ga-zno-thin-film-transistors-by-using-a-thermally-stable-organic-dielectric-layer
#18
Yogeenth Kumaresan, Yusin Pak, Namsoo Lim, Yonghun Kim, Min-Ji Park, Sung-Min Yoon, Hyoc-Min Youn, Heon Lee, Byoung Hun Lee, Gun Young Jung
Flexible In-Ga-ZnO (IGZO) thin film transistor (TFT) on a polyimide substrate is produced by employing a thermally stable SA7 organic material as the multi-functional barrier and dielectric layers. The IGZO channel layer was sputtered at Ar:O2 gas flow rate of 100:1 sccm and the fabricated TFT exhibited excellent transistor performances with a mobility of 15.67 cm(2)/Vs, a threshold voltage of 6.4 V and an on/off current ratio of 4.5 × 10(5). Further, high mechanical stability was achieved by the use of organic/inorganic stacking of dielectric and channel layers...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876887/high-energy-particle-radiation-associated-oncogenic-transformation-in-normal-mice-insight-into-the-connection-between-activation-of-oncotargets-and-oncogene-addiction
#19
Natarajan Aravindan, Sheeja Aravindan, Krishnan Manickam, Mohan Natarajan
Concerns on high-energy particle radiation-induced tumorigenic transformation of normal tissue in astronauts, and in cancer patients undergoing radiotherapy, emphasizes the significance of elucidating the mechanisms involved in radiogenic transformation processes. Mostly used genetically modified or tumor-prone models are less reliable in determining human health risk in space or protracted post-treatment normal tissue toxicity. Here, in wild type C57BL/6 mice, we related the deregulation of distinctive set of tissue-specific oncotargets in major organs upon (56)Fe (600 MeV/amu; 0...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27870055/cancer-risks-after-solid-organ-transplantation-and-after-long-term-dialysis
#20
Maria Hortlund, Laila Sara Arroyo Mühr, Hans Storm, Gerda Engholm, Joakim Dillner, Davit Bzhalava
Immunosuppression involves an inability to control virus infections and increased incidence of virus-associated cancers. Some cancers without known viral etiology are also increased, but data on exactly which cancer forms are increased has been inconsistent. To provide a reliable and generalizable estimate, with high statistical power and long follow-up time, we assessed cancer risks using comprehensive, population-based registries in 2 different countries and from 2 different immunosuppressed patient groups (solid organ transplant recipients (OTRs) and long-term dialysis patients (LDPs))...
November 21, 2016: International Journal of Cancer. Journal International du Cancer
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