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High reliability organization

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https://www.readbyqxmd.com/read/29222080/the-12-item-self-report-world-health-organization-disability-assessment-schedule-whodas-2-0-administered-via-the-internet-to-individuals-with-anxiety-and-stress-disorders-a-psychometric-investigation-based-on-data-from-two-clinical-trials
#1
Erland Axelsson, Elin Lindsäter, Brjánn Ljótsson, Erik Andersson, Erik Hedman-Lagerlöf
BACKGROUND: The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) is a widespread measure of disability and functional impairment, which is bundled with the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition) for use in psychiatry. Administering psychometric scales via the Internet is an effective way to reach respondents and allow for convenient handling of data. OBJECTIVE: The aim was to study the psychometric properties of the 12-item self-report WHODAS 2...
December 8, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/29220414/detection-of-spontaneous-pulse-using-the-acceleration-signals-acquired-from-cpr-feedback-sensor-in-a-porcine-model-of-cardiac-arrest
#2
Liang Wei, Gang Chen, Zhengfei Yang, Tao Yu, Weilun Quan, Yongqin Li
BACKGROUND: Reliable detection of return of spontaneous circulation with minimal interruptions of chest compressions is part of high-quality cardiopulmonary resuscitation (CPR) and routinely done by checking pulsation of carotid arteries. However, manual palpation was time-consuming and unreliable even if performed by expert clinicians. Therefore, automated accurate pulse detection with minimal interruptions of chest compression is highly desirable during cardiac arrest especially in out-of-hospital settings...
2017: PloS One
https://www.readbyqxmd.com/read/29219911/practical-application-of-high-reliability-principles-in-healthcare-to-optimize-quality-and-safety-outcomes
#3
Cynthia A Oster, Sherilyn Deakins
Application of high-reliability (HR) principles into daily healthcare processes can drive culture change, safety, and quality outcomes. Understanding foundational practices to full HR principle integration in an organization's quality and safety programs strengthens evidence-based practices, reduces clinical variation, and improves nurse-sensitive patient outcomes. Quantifying the cost impact of reduction in preventable harm and improved nurse-sensitive patient outcomes is an initial attempt to formulate an empiric measure of nursing value...
January 2018: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29219066/a-multi-network-clustering-method-for-detecting-protein-complexes-from-multiple-heterogeneous-networks
#4
Le Ou-Yang, Hong Yan, Xiao-Fei Zhang
BACKGROUND: The accurate identification of protein complexes is important for the understanding of cellular organization. Up to now, computational methods for protein complex detection are mostly focus on mining clusters from protein-protein interaction (PPI) networks. However, PPI data collected by high-throughput experimental techniques are known to be quite noisy. It is hard to achieve reliable prediction results by simply applying computational methods on PPI data. Behind protein interactions, there are protein domains that interact with each other...
December 1, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29218481/concepts-for-a-therapeutic-prolongation-of-nephrogenesis-in-preterm-and-low-birth-weight-babies-must-correspond-to-structural-functional-properties-in-the-nephrogenic-zone
#5
REVIEW
Will W Minuth
Numerous investigations are dealing with anlage of the mammalian kidney and primary development of nephrons. However, only few information is available about the last steps in kidney development leading at birth to a downregulation of morphogen activity in the nephrogenic zone and to a loss of stem cell niches aligned beyond the organ capsule. Surprisingly, these natural changes in the developmental program display similarities to processes occurring in the kidneys of preterm and low-birth-weight babies. Although those babies are born at a time with a principally intact nephrogenic zone and active niches, a high proportion of them suffers on impairment of nephrogenesis resulting in oligonephropathy, formation of atypical glomeruli, and immaturity of parenchyma...
December 7, 2017: Molecular and Cellular Pediatrics
https://www.readbyqxmd.com/read/29218384/is-it-possible-to-give-a-single-definition-of-the-rectosigmoid-junction
#6
Damien Massalou, David Moszkowicz, Daniela Mariage, Patrick Baqué, Olivier Camuzard, Nicolas Bronsard
AIM: The rectosigmoid junction is the limit separating the sigmoid colon and rectum. This transition zone has different definitions. We want to highlight different landmarks of the rectosigmoid junction (RSJ), to help the clinicians to adopt a consensual definition. METHOD: We reviewed anatomical, endoscopic, physiological and surgical points of view concerning the rectosigmoid junction (RSJ). RESULTS: The rectosigmoid junction has a different definition depending on who is studying it...
December 7, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/29213251/who-wants-to-be-an-intrapreneur-relations-between-employees-entrepreneurial-professional-and-leadership-career-motivations-and-intrapreneurial-motivation-in-organizations
#7
Kim-Yin Chan, Moon-Ho R Ho, Jeffrey C Kennedy, Marilyn A Uy, Bianca N Y Kang, Olexander S Chernyshenko, Kang Yang T Yu
This paper reports an empirical study conducted to examine the relationship between employees' Entrepreneurial, Professional, and Leadership (EPL) career motivations and their intrapreneurial motivation. Using data collected from 425 working adults in the research/innovation and healthcare settings, we develop a self-report measure of employee intrapreneurial motivation. We also adapt an existing self-report measure of E, P, and L career motivations (previously developed and used with university students) for use with working adult organizational employees...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29210762/decentralization-the-corridor-is-the-problem-not-the-alcove
#8
D Kirk Hamilton, Sandra M Swoboda, Jin-Ting Lee, Diana C Anderson
There is controversy today about whether decentralized intensive care unit (ICU) designs featuring alcoves and multiple sites for charting are effective. There are issues relating to travel distance, visibility of patients, visibility of staff colleagues, and communications among caregivers, along with concerns about safety risk. When these designs became possible and popular, many ICU designs moved away from the high-visibility circular, semicircular, or box-like shapes and began to feature units with more linear shapes and footprints similar to acute bed units...
January 2018: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/29209860/identification-of-inhibitory-compounds-against-singapore-grouper-iridovirus-infection-by-cell-viability-based-screening-assay-and-droplet-digital-pcr
#9
Kuntong Jia, Yongming Yuan, Wei Liu, Lan Liu, Qiwei Qin, Meisheng Yi
Singapore grouper iridovirus (SGIV) is one of the major causative agents of fish diseases and has caused significant economic losses in the aquaculture industry. There is currently no commercial vaccine or effective antiviral treatment against SGIV infection. Annually, an increasing number of small molecule compounds from various sources have been produced, and many are proved to be potential inhibitors against viruses. Here, a high-throughput in vitro cell viability-based screening assay was developed to identify antiviral compounds against SGIV using the luminescent-based CellTiter-Glo reagent in cultured grouper spleen cells by quantificational measurement of the cytopathic effects induced by SGIV infection...
December 5, 2017: Marine Biotechnology
https://www.readbyqxmd.com/read/29205536/energy-structure-function-maps-cartography-for-materials-discovery
#10
REVIEW
Graeme M Day, Andrew I Cooper
Some of the most successful approaches to structural design in materials chemistry have exploited strong directional bonds, whose geometric reliability lends predictability to solid-state assembly. For example, metal-organic frameworks are an important design platform in materials chemistry. By contrast, the structure of molecular crystals is defined by a balance of weaker intermolecular forces, and small changes to the molecular building blocks can lead to large changes in crystal packing. Hence, empirical rules are inherently less reliable for engineering the structures of molecular solids...
December 4, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29203058/potential-impact-of-the-herbicide-2-4-dichlorophenoxyacetic-acid-on-human-and-ecosystems
#11
REVIEW
Faisal Islam, Jian Wang, Muhammad A Farooq, Muhammad S S Khan, Ling Xu, Jinwen Zhu, Min Zhao, Stéphane Muños, Qing X Li, Weijun Zhou
The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is applied directly to aquatic and conventional farming systems to control weeds, and is among the most widely distributed pollutants in the environment. Non-target organisms are exposed to 2,4-D via several ways, which could produce toxic effects depending on the dose, frequency of exposure, and the host factors that influence susceptibility and sensitivity. An increasing number of experimental evidences have shown concerns about its presence/detection in the environment, because several investigations have pointed out its potential lethal effects on non-target organisms...
December 1, 2017: Environment International
https://www.readbyqxmd.com/read/29203020/evidence-based-safety-ebs-management-a-new-approach-to-teaching-the-practice-of-safety-management-sm
#12
Bing Wang, Chao Wu, Bo Shi, Lang Huang
INTRODUCTION: In safety management (SM), it is important to make an effective safety decision based on the reliable and sufficient safety-related information. However, many SM failures in organizations occur for a lack of the necessary safety-related information for safety decision-making. Since facts are the important basis and foundation for decision-making, more efforts to seek the best evidence relevant to a particular SM problem would lead to a more effective SM solution. Therefore, the new paradigm for decision-making named "evidence-based practice (EBP)" can hold important implications for SM, because it uses the current best evidence for effective decision-making...
December 2017: Journal of Safety Research
https://www.readbyqxmd.com/read/29202420/detecting-sulfamethoxazole-and-carbamazepine-in-groundwater-is-elisa-a-reliable-screening-tool
#13
Aliesha L Krall, Sarah M Elliott, Melinda L Erickson, Byron A Adams
In recent years, numerous studies have reported the prevalence of organic micropollutants in natural waters. There is an increasing interest in assessing the occurrence and transport of these contaminants in groundwater because a large number of people in the United States rely on groundwater for their drinking water. However, commonly used mass-spectrometry-based analytical methods are expensive and time-consuming. The enzyme-linked immunosorbent assay (ELISA) method offers an inexpensive analytical alternative that provides semi-quantitative results in a relatively quick timeframe...
December 1, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29201623/enhanced-charge-collection-in-mof-525-pedot-nanotube-composites-enable-highly-sensitive-biosensing
#14
Tzu-Yen Huang, Chung-Wei Kung, Yu-Te Liao, Sheng-Yuan Kao, Mingshan Cheng, Ting-Hsiang Chang, Joel Henzie, Hatem R Alamri, Zeid A Alothman, Yusuke Yamauchi, Kuo-Chuan Ho, Kevin C-W Wu
With the aim of a reliable biosensing exhibiting enhanced sensitivity and selectivity, this study demonstrates a dopamine (DA) sensor composed of conductive poly(3,4-ethylenedioxythiophene) nanotubes (PEDOT NTs) conformally coated with porphyrin-based metal-organic framework nanocrystals (MOF-525). The MOF-525 serves as an electrocatalytic surface, while the PEDOT NTs act as a charge collector to rapidly transport the electron from MOF nanocrystals. Bundles of these particles form a conductive interpenetrating network film that together: (i) improves charge transport pathways between the MOF-525 regions and (ii) increases the electrochemical active sites of the film...
November 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29200663/in-search-of-standards-to-support-circularity-in-product-policies-a-systematic-approach
#15
Paolo Tecchio, Catriona McAlister, Fabrice Mathieux, Fulvio Ardente
The aspiration of a circular economy is to shift material flows toward a zero waste and pollution production system. The process of shifting to a circular economy has been initiated by the European Commission in their action plan for the circular economy. The EU Ecodesign Directive is a key policy in this transition. However, to date the focus of access to market requirements on products has primarily been upon energy efficiency. The absence of adequate metrics and standards has been a key barrier to the inclusion of resource efficiency requirements...
December 1, 2017: Journal of Cleaner Production
https://www.readbyqxmd.com/read/29200426/characterization-of-dfoxo-binding-sites-upstream-of-the-insulin-receptor-p2-promoter-across-the-drosophila-phylogeny
#16
Dorcas J Orengo, Montserrat Aguadé, Elvira Juan
The insulin/TOR signal transduction pathway plays a critical role in determining such important traits as body and organ size, metabolic homeostasis and life span. Although this pathway is highly conserved across the animal kingdom, the affected traits can exhibit important differences even between closely related species. Evolutionary studies of regulatory regions require the reliable identification of transcription factor binding sites. Here we have focused on the Insulin Receptor (InR) expression from its P2 promoter in the Drosophila genus, which in D...
2017: PloS One
https://www.readbyqxmd.com/read/29199591/copine-3-as-a-novel-potential-drug-target-for-non-small-cell-lung-carcinoma
#17
Kunnathur Murugesan Sakthivel, Venugopal Vinod Prabhu
Cancer originates from uncontrolled cell division in any part of the body. The universal burden of cancer continues to increase, and its treatment remains ever more challenging. Among several cancers, lung cancer is the second most common, causing 1.6 million deaths worldwide per year. Approximately 85% of lung cancers are non-small-cell lung carcinomas (NSCLCs), which are considerably more difficult to treat than other cancers. Although various imaging, biopsy, and histopathological analyses are widely used, there are no effective or reliable biomarkers for detecting early lung carcinoma, particularly NSCLC...
2017: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/29198710/the-protective-effect-of-orally-administered-redox-nanoparticle-on-intestinal-ischemia-reperfusion-injury-in-mice
#18
Tomohiro Ueda, Tomohisa Takagi, Kazuhiro Katada, Takaya Iida, Katsura Mizushima, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Takeshi Ishikawa, Yuji Naito, Yukio Nagasaki, Yoshito Itoh
BACKGROUND: Intestinal ischemia-reperfusion (I-R) injury is a serious abdominal condition leading to multiple organ failure with high mortality. However, no reliable treatment is available. Novel redox nanoparticle (RNPO) was recently developed, and its efficacy for several intestinal inflammatory conditions has been reported. To this end, the aim of this study was to investigate the therapeutic effects of RNPO on intestinal I-R injury in mice. METHODS: Ischemia was induced in the small intestine of C57BL/6 mice by occluding the superior mesenteric artery for 45 min under anesthesia followed by reperfusion for 4 h...
November 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29196982/a-brief-instrument-to-assess-both-burnout-and-professional-fulfillment-in-physicians-reliability-and-validity-including-correlation-with-self-reported-medical-errors-in-a-sample-of-resident-and-practicing-physicians
#19
Mickey Trockel, Bryan Bohman, Emi Lesure, Maryam S Hamidi, Dana Welle, Laura Roberts, Tait Shanafelt
OBJECTIVE: The objective of this study was to evaluate the performance of the Professional Fulfillment Index (PFI), a 16-item instrument to assess physicians' professional fulfillment and burnout, designed for sensitivity to change attributable to interventions or other factors affecting physician well-being. METHODS: A sample of 250 physicians completed the PFI, a measure of self-reported medical errors, and previously validated measures including the Maslach Burnout Inventory (MBI), a one-item burnout measure, the World Health Organization's abbreviated quality of life assessment (WHOQOL-BREF), and PROMIS short-form depression, anxiety, and sleep-related impairment scales...
December 1, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/29196066/cough-due-to-tuberculosis-and-other-chronic-infections-chest-guideline-and-expert-panel-report
#20
Stephen K Field, Patricio Escalante, Dina A Fisher, Belinda Ireland, Richard S Irwin
BACKGROUND: Cough is common in pulmonary tuberculosis (TB) and other chronic respiratory infections. Identifying features that predict whether pulmonary TB is the cause would help target appropriate individuals for rapid and cost-effective screening, potentially limiting disease progression, and preventing transmission to others. METHODS: A systematic literature search for individual studies to answer 8 Key questions (KQ) was conducted according to established Chest Organization methods using the following databases: MEDLINE via PubMed, EMBASE, Scopus and the Cochrane Database of Systematic Reviews from 1/1/1984 to April 2014...
November 28, 2017: Chest
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