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https://www.readbyqxmd.com/read/29054656/development-and-evaluation-of-diffusive-gradients-in-thin-films-technique-for-measuring-antibiotics-in-seawater
#1
Huaijun Xie, Jingwen Chen, Qining Chen, Chang-Er L Chen, Juan Du, Feng Tan, Chengzhi Zhou
As coastal waters in many regions of the world have been polluted by organic micro-pollutants such as antibiotics that can promote the development of resistance genes, it is of importance to monitor the levels of antibiotics in coastal waters. For this purpose, a reliable and robust sampling approach based on diffusive gradients in thin films (DGT) was developed in this study. The DGT measurement can provide a time weighted average concentration of pollutants. A binding material (resin XDA-1) with a high adsorption capacity for antibiotics, which can resist the pH and ionic strength of seawaters, was selected...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29052186/a-rapid-and-efficient-chip-protocol-to-profile-chromatin-binding-proteins-and-epigenetic-modifications-in-arabidopsis
#2
Bénédicte Desvoyes, Zaida Vergara, Joana Sequeira-Mendes, Sofia Madeira, Crisanto Gutierrez
Chromatin immunoprecipitation (ChIP) is a widely used and very powerful procedure to identify the proteins that are associated with the DNA to regulate developmental processes. These proteins can be transcription factors, or specific histone variants and modified histones, which are all crucial for gene regulation. In order to obtain reliable results, ChIP must be carried out under highly reproducible conditions. Here, we describe a simple and fast ChIP protocol adapted for Arabidopsis seedlings, which can serve as a basis for other species, organs or more sophisticated procedures, such as the sequential ChIP...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29046916/enhancement-of-charge-transfer-between-graphene-and-donor-%C3%AF-acceptor-molecule-for-ultrahigh-sensing-performance
#3
Wenle Pei, Tingting Zhang, Yao Wang, Zhuo Chen, Ahmad Umar, Hao Li, Wei Guo
In this work, we report the formation of a supramolecular assembly of graphene with a donor-π-acceptor (D-π-A) molecule to detect low concentration NO2. 5-Aminonaphthalene-1-sulfonic acid (ANS) was used herein to π-π stack with reduced graphene oxide (rGO), the resulting π-conjugated bridge being linked by a donor unit (-NH2) and an acceptor unit (-SO3H). The prepared ANS-rGO shows the highest response (Ra/Rg = 13.2 to 10 ppm NO2) so far among the reported organic molecule modified graphene materials, and excellent selectivity and reliable reversibility at room temperature...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/29046709/detecting-spikes-of-wheat-plants-using-neural-networks-with-laws-texture-energy
#4
Li Qiongyan, Jinhai Cai, Bettina Berger, Mamoru Okamoto, Stanley J Miklavcic
BACKGROUND: The spike of a cereal plant is the grain-bearing organ whose physical characteristics are proxy measures of grain yield. The ability to detect and characterise spikes from 2D images of cereal plants, such as wheat, therefore provides vital information on tiller number and yield potential. RESULTS: We have developed a novel spike detection method for wheat plants involving, firstly, an improved colour index method for plant segmentation and, secondly, a neural network-based method using Laws texture energy for spike detection...
2017: Plant Methods
https://www.readbyqxmd.com/read/29045649/understanding-evolutionary-impacts-of-seasonality-an-introduction-to-the-symposium
#5
Caroline M Williams, Gregory J Ragland, Gustavo Betini, Lauren B Buckley, Zachary A Cheviron, Kathleen Donohue, Joe Hereford, Murray M Humphries, Simeon Lisovski, Katie E Marshall, Paul S Schmidt, Kimberly S Sheldon, Øystein Varpe, Marcel E Visser
Seasonality is a critically important aspect of environmental variability, and strongly shapes all aspects of life for organisms living in highly seasonal environments. Seasonality has played a key role in generating biodiversity, and has driven the evolution of extreme physiological adaptations and behaviors such as migration and hibernation. Fluctuating selection pressures on survival and fecundity between summer and winter provide a complex selective landscape, which can be met by a combination of three outcomes of adaptive evolution: genetic polymorphism, phenotypic plasticity, and bet-hedging...
October 16, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29033888/concussion-as-a-multi-scale-complex-system-an-interdisciplinary-synthesis-of-current-knowledge
#6
REVIEW
Erin S Kenzie, Elle L Parks, Erin D Bigler, Miranda M Lim, James C Chesnutt, Wayne Wakeland
Traumatic brain injury (TBI) has been called "the most complicated disease of the most complex organ of the body" and is an increasingly high-profile public health issue. Many patients report long-term impairments following even "mild" injuries, but reliable criteria for diagnosis and prognosis are lacking. Every clinical trial for TBI treatment to date has failed to demonstrate reliable and safe improvement in outcomes, and the existing body of literature is insufficient to support the creation of a new classification system...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29032495/laparoscopic-versus-open-umbilical-or-paraumbilical-hernia-repair-a-systematic-review-and-meta-analysis
#7
REVIEW
S Hajibandeh, S Hajibandeh, A Sreh, A Khan, D Subar, L Jones
OBJECTIVES: To compare outcomes of laparoscopic repair to open repair of umbilical and paraumbilical hernias. METHODS: We performed a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement standards. The review protocol was registered with International Prospective Register of Systematic Reviews (Registration Number: CRD42016052131). We conducted a search of electronic information sources, including MEDLINE; EMBASE; CINAHL; the Cochrane Central Register of Controlled Trials (CENTRAL); the World Health Organization International Clinical Trials Registry; ClinicalTrials...
October 14, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29031051/17%C3%AE-estradiol-induces-cyto-genotoxicity-on-blood-cells-of-common-carp-cyprinus-carpio
#8
Luis Orozco-Hernández, Adriana Andrea Gutiérrez-Gómez, Nely SanJuan-Reyes, Hariz Islas-Flores, Sandra García-Medina, Marcela Galar-Martínez, Octavio Dublán-García, Reyna Natividad, Leobardo Manuel Gómez-Oliván
17β-Estradiol, a natural hormone present at high concentrations in aquatic ecosystems, affects and modifies endocrine function in animals. In recent years research workers have expressed concern over its potential effects on aquatic organisms; however, little is known about its capacity to induce genetic damage or the pro-apoptotic effects of such damage on fish. Therefore, this study aimed to evaluate 17β-estradiol-induced cyto-genotoxicity in blood cells of the common carp Cyprinus carpio exposed to different concentrations (1 ng, 1 μg and 1 mg L(-1))...
October 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/29030671/graphene-based-label-free-electrochemical-aptasensor-for-rapid-and-sensitive-detection-of-foodborne-pathogen
#9
Shalini Muniandy, Ignatius Julian Dinshaw, Swe Jyan Teh, Chin Wei Lai, Fatimah Ibrahim, Kwai Lin Thong, Bey Fen Leo
Reduced graphene oxide (rGO) has emerged as a promising nanomaterial for reliable detection of pathogenic bacteria due to its exceptional properties such as ultrahigh electron transfer ability, large surface to volume ratio, biocompatibility, and its unique interactions with DNA bases of the aptamer. In this study, rGO-azophloxine (AP) nanocomposite aptasensor was developed for a sensitive, rapid, and robust detection of foodborne pathogens. Besides providing an excellent conductive and soluble rGO nanocomposite, the AP dye also acts as an electroactive indicator for redox reactions...
October 13, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29029692/e-health-readiness-assessment-factors-and-measuring-tools-a-systematic-review
#10
REVIEW
Salifu Yusif, Abdul Hafeez-Baig, Jeffrey Soar
BACKGROUND: The evolving, adoption and high failure nature of health information technology (HIT)/IS/T systems requires effective readiness assessment to avert increasing failures while increasing system benefits. However, literature on HIT readiness assessment is myriad and fragmented. This review bares the contours of the available literature concluding in a set of manageable and usable recommendations for policymakers, researchers, individuals and organizations intending to assess readiness for any HIT implementation...
November 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29028316/tailoring-nanocrystalline-metal-organic-frameworks-as-fluorescent-dye-carriers-for-bioimaging
#11
UnJin Ryu, Jounghyun Yoo, Woosung Kwon, Kyung Min Choi
Challenges exist in taking advantage of dye molecules for reliable and reproducible molecular probes in biomedical applications. In this study, we show how to utilize the dye molecules for bioimaging within protective carriers of nanocrystalline metal-organic frameworks (nMOFs) particles. Specifically, Resorufin and Rhodamine-6G having different molecular sizes were encapsulated within close-fitting pores of nMOF-801 and nUiO-67 particles, respectively. The resulting nanocrystalline particles have high crystallinity, uniform size, and morphology and preserve enhanced photoluminescence properties with exceptional stabilities in biomedical environment...
October 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29027507/development-of-an-mhealth-trauma-registry-in-the-middle-east-using-an-implementation-science-framework
#12
Amber Mehmood, Edward Chan, Katharine Allen, Ammar Al-Kashmiri, Ali Al-Busaidi, Jehan Al-Abri, Mohamed Al-Yazidi, Abdullah Al-Maniri, Adnan A Hyder
BACKGROUND: Trauma registries (TRs) play a vital role in the assessment of trauma care, but are often underutilized in countries with a high burden of injuries. OBJECTIVES: We investigated whether information and communications technology (ICT) such as mobile health (mHealth) could enable the design of a tablet-based application for healthcare professionals. This would be used to inform trauma care and acquire surveillance data for injury control and prevention in Oman...
2017: Global Health Action
https://www.readbyqxmd.com/read/29027486/the-cancer-threshold-of-toxicological-concern-ttc-in-relation-to-foodstuffs-and-pharmaceuticals-a-potentially-useful-concept-compromised-by-a-dubious-derivation
#13
D J Snodin
The cancer threshold of toxicological concern (TTC) as determined by Kroes et al. in 2004 (0.15 µg/day and 1.5 µg/day at risk levels of 1 in 10(6) or 10(5), respectively) has been uncritically employed as a key metric in multiple regulatory guidance documents. There are numerous concerns regarding transparency and the highly conservative methodology in relation to its derivation; moreover, no formal confirmation has been undertaken by any regulatory body prior to its adoption. A recent joint report from the European Food Safety Authority and World Health Organization follows this trend, largely replicating previous conclusions and downplaying the need for a re-assessment...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29024453/the-histopathologic-reliability-of-tissue-taken-from-cadavers-within-the-gross-anatomy-laboratory
#14
Guenevere Rae, William P Newman, Robin McGoey, Supriya Donthamsetty, Aryn C Karpinski, Jeffrey Green
The purpose of this study was to examine the histopathologic reliability of embalmed cadaveric tissue taken from the gross anatomy laboratory. Tissue samples from hearts, livers, lungs, and kidneys were collected after the medical students' dissection course was completed. All of the cadavers were embalmed in a formalin-based fixative solution. The tissue was processed, embedded in paraffin, sectioned at six micrometers, and stained with H&E. The microscope slides were evaluated by a board certified pathologist to determine whether the cellular components of the tissues were preserved at a high enough quality to allow for histopathologic diagnosis...
October 10, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/29023580/effects-of-fish-movement-assumptions-on-the-design-of-a-marine-protected-area-to-protect-an-overfished-stock
#15
Jorge Cornejo-Donoso, Baldvin Einarsson, Bjorn Birnir, Steven D Gaines
Marine Protected Areas (MPA) are important management tools shown to protect marine organisms, restore biomass, and increase fisheries yields. While MPAs have been successful in meeting these goals for many relatively sedentary species, highly mobile organisms may get few benefits from this type of spatial protection due to their frequent movement outside the protected area. The use of a large MPA can compensate for extensive movement, but testing this empirically is challenging, as it requires both large areas and sufficient time series to draw conclusions...
2017: PloS One
https://www.readbyqxmd.com/read/28994433/wafer-scale-reliable-switching-memory-based-on-2-dimensional-layered-organic-inorganic-halide-perovskite
#16
Ja-Young Seo, Jaeho Choi, Huo-Seon Kim, Jaegyeom Kim, June-Mo Yang, Can Cuhadar, Ji Su Han, Seung-Joo Kim, Donghwa Lee, Ho Won Jang, Nam-Gyu Park
Recently, organic-inorganic halide perovskite (OHP) has been suggested as an alternative to oxides or chalcogenides in resistive switching memory devices due to low operating voltage, high ON/OFF ratio, and flexibility. The most studied OHP is 3-dimensional (3D) MAPbI3. However, MAPbI3 often exhibits less reliable switching behavior probably due to the uncontrollable random formation of conducting filaments. Here, we report the resistive switching property of 2-dimensional (2D) OHP and compare switching characteristics depending on structural dimensionality...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28993590/an-electrochemical-dna-biosensor-based-on-au-reduced-graphene-oxide-nanocomposite-for-transgenic-event-bt63-detection
#17
Chenmeng He, Yali Tang, Sai Wang, Jiahui Liu, Ying Chen, Yiyang Dong, Haijia Su, Tianwei Tan
A simple and reliable electrochemical biosensor based on an in situ synthetic Au-reduced graphene oxide (Au-RGO) nanocomposite was constructed in this work, which is considered to be a potential sensing platform for sensitive and selective Bt63 rice detection. UV-vis spectroscopy, transmission electron microscopy (TEM), and cyclic voltammograms of the surface characterization indicated that RGO was prepared successfully and Au nanoparticles were well dispersed on its surface with an average size of 20 nm. The square-wave voltammetry (SWV) response of the electrochemical marker methylene blue (MB) was chosen to monitor the probe immobilization and target hybridization event...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28992142/researching-safety-culture-deliberative-dialogue-with-a-restorative-lens
#18
Elisiane Lorenzini, Nelly D Oelke, Patricia Beryl Marck, Clarice Maria Dall'agnol
Safety culture is a key component of patient safety. Many patient safety strategies in health care have been adapted from high-reliability organizations (HRO) such as aviation. However, to date, attempts to transform the cultures of health care settings through HRO approaches have had mixed results. We propose a methodological approach for safety culture research, which integrates the theory and practice of restoration science with the principles and methods of deliberative dialogue to support active engagement in critical reflection and collective debate...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28991925/next-generation-elisa-diagnostic-assay-for-chagas-disease-based-on-the-combination-of-short-peptidic-epitopes
#19
Juan Mucci, Santiago J Carmona, Romina Volcovich, Jaime Altcheh, Estefanía Bracamonte, Jorge D Marco, Morten Nielsen, Carlos A Buscaglia, Fernán Agüero
Chagas Disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. Accurate diagnosis is essential for the early identification and follow up of vector-borne cases and to prevent transmission of the disease by way of blood transfusions and organ transplantation. Diagnosis is routinely performed using serological methods, some of which require the production of parasite lysates, parasite antigenic fractions or purified recombinant antigens...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28990525/a-human-proximal-tubular-epithelial-cell-model-to-explore-a-knowledge-gap-on-neonatal-drug-disposition
#20
Ahmed Reda, Anke Raaijmakers, Saskia van Dorst, Charlotte G G M Pauwels, Karel Allegaert, Mohamed A Elmonem, Rosalinde Masereeuw, Lambertus van den Heuvel, Elena Levtchenko, Fanny Oliveira Arcolino
BACKGROUND: Finding the right drug-dosage for neonates is still a challenge. Until now, neonatal doses are extrapolated from adults and children doses. However, there are differences between neonatal and adult kidney physiology that should be considered, especially when it comes to drug metabolism and/or transport. Studying renal drug disposition in neonates is limited by the lack of reliable human cell models. OBJECTIVE: To illustrate the feasibility of developing an in vitro model for neonatal proximal tubule epithelial cells (nPTECs) to study renal drug disposition at this age...
October 9, 2017: Current Pharmaceutical Design
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