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https://www.readbyqxmd.com/read/28454481/aln-surface-passivation-of-gan-based-high-electron-mobility-transistors-by-plasma-enhanced-atomic-layer-deposition
#1
An-Jye Tzou, Kuo-Hsiung Chu, I-Feng Lin, Erik Østreng, Yung-Sheng Fang, Xiao-Peng Wu, Bo-Wei Wu, Chang-Hong Shen, Jia-Ming Shieh, Wen-Kuan Yeh, Chun-Yen Chang, Hao-Chung Kuo
We report a low current collapse GaN-based high electron mobility transistor (HEMT) with an excellent thermal stability at 150 °C. The AlN was grown by N2-based plasma enhanced atomic layer deposition (PEALD) and shown a refractive index of 1.94 at 633 nm of wavelength. Prior to deposit AlN on III-nitrides, the H2/NH3 plasma pre-treatment led to remove the native gallium oxide. The X-ray photoelectron spectroscopy (XPS) spectroscopy confirmed that the native oxide can be effectively decomposed by hydrogen plasma...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454385/neuroendocrine-differentiation-is-predictive-of-poor-survival-in-patients-with-stage-ii-colorectal-cancer
#2
Yue Liu, Jinjie He, Jinghong Xu, Jun Li, Yurong Jiao, Dikai Bei, Yeting Hu, Haiyan Chen, Qian Xiao, Kefeng Ding
The diagnosis of neuroendocrine differentiation (NED) is made primarily on the basis of ultrastructure and/or immunohistochemistry (IHC). Synaptophysin (Syn) and chromogranin A (CgA) are two important frequently used NED markers in colorectal cancer (CRC). The association between NED and the prognosis of stage II CRC remains controversial. Administration of adjuvant chemotherapy remains challenging for stage II CRC. Identification of reliable factors that improve the selection of patients with stage II CRC at high risk following surgery is of great importance...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454114/estimating-the-effects-of-transcription-factors-binding-and-histone-modifications-on-gene-expression-levels-in-human-cells
#3
Lu-Qiang Zhang, Qian-Zhong Li
Transcription factors and histone modifications are vital for the regulation of gene expression. Hence, to estimate the effects of transcription factors binding and histone modifications on gene expression, we construct a statistical model for the genome-wide 15 transcription factors binding data, 10 histone modifications profiles and DNase-I hypersensitivity data in three mammalian. Remarkably, our results show POLR2A and H3K36me3 can highly and consistently predict gene expression in three cell lines. And H3K4me3, H3K27me3 and H3K9ac are more reliable predictors than other histone modifications in human embryonic stem cells...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28453751/the-neurologic-assessment-in-neuro-oncology-nano-scale-a-tool-to-assess-neurologic-function-for-integration-into-the-response-assessment-in-neuro-oncology-rano-criteria
#4
Lakshmi Nayak, Lisa M DeAngelis, Alba A Brandes, David M Peereboom, Evanthia Galanis, Nancy U Lin, Riccardo Soffietti, David R Macdonald, Marc Chamberlain, James Perry, Kurt Jaeckle, Minesh Mehta, Roger Stupp, Alona Muzikansky, Elena Pentsova, Timothy Cloughesy, Fabio M Iwamoto, Joerg-Christian Tonn, Michael A Vogelbaum, Patrick Y Wen, Martin J van den Bent, David A Reardon
Background.: The Macdonald criteria and the Response Assessment in Neuro-Oncology (RANO) criteria define radiologic parameters to classify therapeutic outcome among patients with malignant glioma and specify that clinical status must be incorporated and prioritized for overall assessment. But neither provides specific parameters to do so. We hypothesized that a standardized metric to measure neurologic function will permit more effective overall response assessment in neuro-oncology. Methods...
May 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28453640/pioneering-topological-methods-for-network-based-drug-target-prediction-by-exploiting-a-brain-network-self-organization-theory
#5
Claudio Durán, Simone Daminelli, Josephine M Thomas, V Joachim Haupt, Michael Schroeder, Carlo Vittorio Cannistraci
The bipartite network representation of the drug-target interactions (DTIs) in a biosystem enhances understanding of the drugs' multifaceted action modes, suggests therapeutic switching for approved drugs and unveils possible side effects. As experimental testing of DTIs is costly and time-consuming, computational predictors are of great aid. Here, for the first time, state-of-the-art DTI supervised predictors custom-made in network biology were compared-using standard and innovative validation frameworks-with unsupervised pure topological-based models designed for general-purpose link prediction in bipartite networks...
April 26, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28453544/predicting-herbivore-faecal-nitrogen-using-a-multispecies-near-infrared-reflectance-spectroscopy-calibration
#6
Miriam Villamuelas, Emmanuel Serrano, Johan Espunyes, Néstor Fernández, Jorge R López-Olvera, Mathieu Garel, João Santos, María Ángeles Parra-Aguado, Maurizio Ramanzin, Xavier Fernández-Aguilar, Andreu Colom-Cadena, Ignasi Marco, Santiago Lavín, Jordi Bartolomé, Elena Albanell
Optimal management of free-ranging herbivores requires the accurate assessment of an animal's nutritional status. For this purpose 'near-infrared reflectance spectroscopy' (NIRS) is very useful, especially when nutritional assessment is done through faecal indicators such as faecal nitrogen (FN). In order to perform an NIRS calibration, the default protocol recommends starting by generating an initial equation based on at least 50-75 samples from the given species. Although this protocol optimises prediction accuracy, it limits the use of NIRS with rare or endangered species where sample sizes are often small...
2017: PloS One
https://www.readbyqxmd.com/read/28449563/relationship-between-serum-bilirubin-levels-and-metabolic-syndrome-in-patients-with-schizophrenia-spectrum-disorders
#7
Filiz Karadag, Ceyhan Balci Sengul, Yasar Enli, Kamuran Karakulah, Huseyin Alacam, Bunyamin Kaptanoglu, Ozgur Kalkanci, Hasan Herken
Objective: We investigated the relationship between serum bilirubin levels and metabolic syndrome (MetS), and the longitudinal effects of baseline serum bilirubin concentrations on MetS in patients with schizophrenia spectrum disorders undergoing atypical antipsychotics. Methods: The sample of this study consisted of 131 patients with schizophrenia spectrum disorders. Waist circumference, blood pressure, and levels of triglycerides, high-density lipoprotein cholesterol, fasting glucose, and insulin were evaluated at baseline and at month six...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449388/unobserved-health-care-expenditures-how-important-is-censoring-in-register-data
#8
Christian Philipp Rudolf Schmid
Accurate information on individuals' health service use is important for evaluating health policies and analyzing health care demand. Although register data are considered to be more reliable than survey data, little is known about the extent and effect of censoring of the expenditure distribution in register data. We exploit a recent change in the health provider remuneration system in several Swiss cantons to empirically investigate whether censoring occurs when individuals do not have to disclose their health service use below their deductible level...
April 27, 2017: Health Economics
https://www.readbyqxmd.com/read/28449315/panelcn-mops-copy-number-detection-in-targeted-ngs-panel-data-for-clinical-diagnostics
#9
Gundula Povysil, Antigoni Tzika, Julia Vogt, Verena Haunschmid, Ludwine Messiaen, Johannes Zschocke, Günter Klambauer, Sepp Hochreiter, Katharina Wimmer
Targeted next-generation-sequencing (NGS) panels have largely replaced Sanger sequencing in clinical diagnostics. They allow for the detection of copy number variations (CNVs) in addition to single-nucleotide-variants and small insertions/deletions. However, existing computational CNV detection methods have shortcomings regarding accuracy, quality control, incidental findings, and user-friendliness. We developed panelcn.MOPS, a novel pipeline for detecting CNVs in targeted NGS panel data. Using data from 180 samples, we compared panelcn...
April 27, 2017: Human Mutation
https://www.readbyqxmd.com/read/28449004/minimal-detectable-change-for-balance-measurements-in-patients-with-copd
#10
Wajdi Mkacher, Zouhair Tabka, Yassine Trabelsi
PURPOSE: The purpose of this study was to determine the reliability and minimal detectable change (MDC) of various outcome measures that are potentially suitable for evaluating postural control in individuals with chronic obstructive pulmonary disease (COPD). METHODS: This was a test-retest reliability study. Participants with COPD were asked to complete 5 balance assessments, separated by 1 week. The assessments included Timed Up and Go (TUG) Test, Unipodal Stance Test (UST), Tinetti Test, Berg Balance Scale (BBS), and the Activities Balance Confidence (ABC) scale...
May 2017: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/28448917/assessing-future-changes-in-the-occurrence-of-rainfall-induced-landslides-at-a-regional-scale
#11
S L Gariano, G Rianna, O Petrucci, F Guzzetti
According to the fifth report of the Intergovernmental Panel on Climate Change, an increase in the frequency and the intensity of extreme rainfall is expected in the Mediterranean area. Among different impacts, this increase might result in a variation in the frequency and the spatial distribution of rainfall-induced landslides, and in an increase in the size of the population exposed to landslide risk. We propose a method for the regional-scale evaluation of future variations in the occurrence of rainfall-induced landslides, in response to changes in rainfall regimes...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448893/diabetes-status-modifies-the-association-between-carotid-intima-media-thickness-and-incident-heart-failure-the-atherosclerosis-risk-in-communities-study
#12
Valery S Effoe, Eric E McClendon, Carlos J Rodriguez, Lynne E Wagenknecht, Gregory W Evans, Patricia P Chang, Alain G Bertoni
AIMS: Increasing carotid intima-media thickness (CIMT) is associated with incident heart failure (HF). We investigated whether this association differs by diabetes status. METHODS: We characterized 13,590 Atherosclerosis Risk in Communities Study participants free of baseline HF into normal fasting glucose (NFG, glucose <100mg/dl), impaired fasting glucose (IFG, glucose 100-125mg/dl), and type 2 diabetes (T2D, glucose ≥126mg/dl, self-report, or use of diabetes drugs)...
April 13, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28448824/a-new-quantitative-method-to-assess-disproportionately-enlarged-subarachnoid-space-desh-in-patients-with-possible-idiopathic-normal-pressure-hydrocephalus-the-silver-index
#13
Nicola Benedetto, Carlo Gambacciani, Filippo Aquila, Davide Tiziano Di Carlo, Riccardo Morganti, Paolo Perrini
OBJECTIVES: Preoperative diagnosis of idiopathic normal-pressure hydrocephalus (iNPH) remains challenging. Recently, the presence of disproportionally enlarged subarachnoid spaces and hydrocephalus (DESH) on diagnostic images has been linked to clinical improvement after ventriculoperitoneal (VP) shunt placement. In this study we describe a new quantitative method to assess DESH on CT scans and to evaluate its prognostic value. PATIENTS AND METHODS: A multiplanar reconstruction software was used to retrospectively evaluate prospectively collected radiological data (CT scans) of 26 controls and 29 consecutive patients that underwent VP shunt placement for possible iNPH...
April 19, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28448817/automated-detection-of-pathologic-white-matter-alterations-in-alzheimer-s-disease-using-combined-diffusivity-and-kurtosis-method
#14
Yuanyuan Chen, Miao Sha, Xin Zhao, Jianguo Ma, Hongyan Ni, Wei Gao, Dong Ming
Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) are important diffusion MRI techniques for detecting microstructure abnormities in diseases such as Alzheimer's. The advantages of DKI over DTI have been reported generally; however, the indistinct relationship between diffusivity and kurtosis has not been clearly revealed in clinical settings. In this study, we hypothesize that the combination of diffusivity and kurtosis in DKI improves the capacity of DKI to detect Alzheimer's disease compared with diffusivity or kurtosis alone...
April 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28448759/ft3-is-higher-in-males-than-in-females-and-decreases-over-the-lifespan
#15
David Strich, Gilad Karavani, Shalom Edri, Cherut Chay, David Gillis
OBJECTIVE: Normal changes in Free triiodothyronine (FT3), Free thyroxine (FT4) and thyroid stimulating hormone (TSH) levels over the lifespan and differences between genders are not well documented, mainly because even the largest-scale studies available include relatively small cohorts. The aim of this study was to define age-related trends including gender differences based on reliable data. METHODS: A large database including serum thyroid tests drawn in community clinics was studied...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28448659/evaluation-of-ecological-momentary-assessment-for-tinnitus-severity
#16
Rachel L Goldberg, Marilyn L Piccirillo, Joyce Nicklaus, Andrew Skillington, Eric Lenze, Thomas L Rodebaugh, Dorina Kallogjeri, Jay F Piccirillo
Importance: Existing patient-reported outcome measures of tinnitus assess the severity and disability retrospectively, which may result in adequate reliability, but cannot capture the fluctuating and individualized nature of tinnitus. Experience sampling may provide an alternative. Objective: To use an ecological momentary assessment (EMA) to measure tinnitus disability and associated constructs. Design, Setting, and Participants: Forty adults with tinnitus provided self-report of their tinnitus bother using 5 questions measured by EMA, as well as standard retrospective outcome measures...
April 27, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28448639/cryptic-diversity-of-the-subfamily-calaphidinae-hemiptera-aphididae-revealed-by-comprehensive-dna-barcoding
#17
Yerim Lee, Wonhoon Lee, Mariusz Kanturski, Robert G Foottit, Shin-Ichi Akimoto, Seunghwan Lee
Aphids are a species rich group comprising many important pests. However, species identification can be very difficult for aphids due to their morphological ambiguity. DNA barcoding has been widely adopted for rapid and reliable species identification as well as cryptic species detection. In this study, we investigated cryptic diversity in the subfamily Calaphidinae (Hemiptera: Aphididae) based on 899 sequences of cytochrome c oxidase I (COI) for 115 morphospecies (78 species collected in this study and sequences of 73 species downloaded from Genbank)...
2017: PloS One
https://www.readbyqxmd.com/read/28448536/lateral-flow-immunoassay-for-on-site-detection-of-xanthomonas-arboricola-pv-pruni-in-symptomatic-field-samples
#18
Pablo López-Soriano, Patricia Noguera, María Teresa Gorris, Rosa Puchades, Ángel Maquieira, Ester Marco-Noales, María M López
Xanthomonas arboricola pv. pruni is a quarantine pathogen and the causal agent of the bacterial spot disease of stone fruits and almond, a major threat to Prunus species. Rapid and specific detection methods are essential to improve disease management, and therefore a prototype of a lateral flow immunoassay (LFIA) was designed for the detection of X. arboricola pv. pruni in symptomatic field samples. It was developed by producing polyclonal antibodies which were then combined with carbon nanoparticles and assembled on nitrocellulose strips...
2017: PloS One
https://www.readbyqxmd.com/read/28448058/a-rapid-automated-protocol-for-muscle-fiber-population-analysis-in-rat-muscle-cross-sections-using-myosin-heavy-chain-immunohistochemistry
#19
Konstantin D Bergmeister, Marion Gröger, Martin Aman, Anna Willensdorfer, Krisztina Manzano-Szalai, Stefan Salminger, Oskar C Aszmann
Quantification of muscle fiber populations provides a deeper insight into the effects of disease, trauma, and various other influences on skeletal muscle composition. Various time-consuming methods have traditionally been used to study fiber populations in many fields of research. However, recently developed immunohistochemical methods based on myosin heavy chain protein expression provide a quick alternative to identify multiple fiber types in a single section. Here, we present a rapid, reliable and reproducible protocol for improved staining quality, allowing automatic acquisition of whole cross sections and automatic quantification of fiber populations with ImageJ...
March 28, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28448053/automated-contraction-analysis-of-human-engineered-heart-tissue-for-cardiac-drug-safety-screening
#20
Ingra Mannhardt, Umber Saleem, Anika Benzin, Thomas Schulze, Birgit Klampe, Thomas Eschenhagen, Arne Hansen
Cardiac tissue engineering describes techniques to constitute three dimensional force-generating engineered tissues. For the implementation of these procedures in basic research and preclinical drug development, it is important to develop protocols for automated generation and analysis under standardized conditions. Here, we present a technique to generate engineered heart tissue (EHT) from cardiomyocytes of different species (rat, mouse, human). The technique relies on the assembly of a fibrin-gel containing dissociated cardiomyocytes between elastic polydimethylsiloxane (PDMS) posts in a 24-well format...
April 15, 2017: Journal of Visualized Experiments: JoVE
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