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https://www.readbyqxmd.com/read/28346886/simultaneous-determination-of-amitraz-chlordimeform-formetanate-and-their-main-metabolites-in-human-urine-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#1
Xue Gao, Yanglan Tan, Hao Guo
A rapid, simple and reliable high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method was developed for simultaneous determination of amitraz, chlordimeform, formetanate and their main metabolites, N-(2,4-dimethylphenyl)-N-methyl-formamidine (DMPF), 2,4-dimethylformamidine (DMF), 2,4-dimethylaniline (DMA), 4-chloro-2-methylaniline and 3-hydroxyacetanilide in human urine. The urine samples were mixed with buffer solutions (pH 8) and subsequently cleaned up by solid supported liquid/liquid extraction (SLE)...
March 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28346795/understanding-the-emission-impacts-of-hov-to-hot-lane-conversions-experience-from-atlanta-ga
#2
Yanzhi Ann Xu, Haobing Liu, Michael O Rodgers, Angshuman Guin, Michael Hunter, Adnan Sheikh, Randall L Guensler
Converting a congested High Occupancy Vehicle (HOV) lane into a High Occupancy Toll (HOT) lane is a viable option for improving travel time reliability for carpools and buses that use the managed lane. However, the emission impacts of HOV-to-HOT-conversions are not well understood. The lack of emissions impact quantification for HOT conversions creates a policy challenge for agencies making transportation funding choices. The goal of this paper is to evaluate the case study before-and-after changes in vehicle emissions for the Atlanta, GA I-85 HOV/HOT lane conversion project, implemented in October, 2011...
March 27, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28346746/simultaneous-determination-of-4-hydroxyphenyl-lactic-acid-4-hydroxyphenyl-acetic-acid-and-3-4-hydroxyphenyl-propionic-acid-in-human-urine-by-ultra-high-performance-liquid-chromatography-with-fluorescence-detection
#3
Yongli Yang, Fan Liu, Yiqun Wan
A simple and reliable method was established for simultaneous determination of 4-hydroxyphenyl acetic acid, 4-hydroxyphenyl lactic acid, and 3-4-hydroxyphenyl propionic acid in human urine by high-performance liquid chromatography with fluorescence detection. Solid-phase extraction was used to eliminate the interferences in urine. The separation of three analytes was achieved using a C18 column and a mobile phase formed by a 95:5 v/v mixture of 50 mmol/L ammonium acetate buffer at pH 6.8 that contained 5 mmol/L tetrabutyl ammonium bromide and acetonitrile...
March 27, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28346487/ml2motif-reliable-extraction-of-discriminative-sequence-motifs-from-learning-machines
#4
Marina M-C Vidovic, Marius Kloft, Klaus-Robert Müller, Nico Görnitz
High prediction accuracies are not the only objective to consider when solving problems using machine learning. Instead, particular scientific applications require some explanation of the learned prediction function. For computational biology, positional oligomer importance matrices (POIMs) have been successfully applied to explain the decision of support vector machines (SVMs) using weighted-degree (WD) kernels. To extract relevant biological motifs from POIMs, the motifPOIM method has been devised and showed promising results on real-world data...
2017: PloS One
https://www.readbyqxmd.com/read/28346385/intelligent-diagnosis-method-for-rotating-machinery-using-dictionary-learning-and-singular-value-decomposition
#5
Te Han, Dongxiang Jiang, Xiaochen Zhang, Yankui Sun
Rotating machinery is widely used in industrial applications. With the trend towards more precise and more critical operating conditions, mechanical failures may easily occur. Condition monitoring and fault diagnosis (CMFD) technology is an effective tool to enhance the reliability and security of rotating machinery. In this paper, an intelligent fault diagnosis method based on dictionary learning and singular value decomposition (SVD) is proposed. First, the dictionary learning scheme is capable of generating an adaptive dictionary whose atoms reveal the underlying structure of raw signals...
March 27, 2017: Sensors
https://www.readbyqxmd.com/read/28346325/clinical-judgment-is-not-reliable-for-reducing-whole-body-computed-tomography-scanning-after-isolated-high-energy-blunt-trauma
#6
Thomas Mistral, Vivien Brenckmann, Laurence Sanders, Jean-Luc Bosson, Gilbert Ferretti, Frederic Thony, Samuel M Galvagno, Jean-François Payen, Pierre Bouzat
BACKGROUND: The purpose of this study was to test the diagnostic performance of clinical judgment for the prediction of a significant injury with whole-body computed tomography scanning after high-energy trauma. METHODS: The authors conducted an observational prospective study in a single level-I trauma center. Adult patients were included if they had an isolated high-energy injury. Senior trauma leaders were asked to make a clinical judgment regarding the likelihood of a significant injury before performance of a whole-body computed tomography scan...
March 27, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28346276/comparison-of-noncontact-specular-and-confocal-microscopy-for-evaluation-of-corneal-endothelium
#7
Jianyan Huang, Jyotsna Maram, Tudor C Tepelus, Srinivas R Sadda, Vikas Chopra, Olivia L Lee
PURPOSE: To compare endothelial cell analysis obtained by noncontact specular and confocal microscopy, using the Konan NSP-9900 and Nidek ConfoScan4 systems, respectively. METHODS: Three groups including 70 healthy eyes, 49 eyes with Fuchs endothelial corneal dystrophy (FECD), and 78 eyes with glaucoma were examined with both the Konan NSP-9900 specular microscope and the Nidek ConfocScan4 confocal microscope. Certified graders at the Doheny Image Reading Center compared corneal endothelial images from both instruments side by side to assess image quality...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28346218/wafer-scale-production-of-highly-uniform-two-dimensional-mos2-by-metal-organic-chemical-vapor-deposition
#8
TaeWan Kim, Jihun Mun, Hyeji Park, DaeHwa Joung, Mangesh Diware, Won Chegal, Jonghoo Park, Soo-Hwan Jeong, Sang-Woo Kang
Semiconducting two-dimensional (2D) materials, particularly, extremely thin molybdenum disulfide (MoS2) films are attracting considerable attention from the academia and industry owing to their distinctive optical and electrical properties. Here, we present the direct growth of a MoS2 monolayer with unprecedented spatial and structural uniformity across an entire 8-inch SiO2/Si wafer. The influences of growth pressure, ambient gases (Ar, H2), and S/Mo molar flow ratio on the MoS2 layered growth were explored by considering the domain size, nucleation sites, morphology, and impurity incorporation...
March 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28346101/semiautomatic-high-content-analysis-of-complex-images-from-cocultures-of-vascular-smooth-muscle-cells-and-macrophages
#9
Matthias Roeper, Ruediger C Braun-Dullaeus, Sönke Weinert
Automatization in microscopy, cell culture, and the ease of digital imagery allow obtainment of more information from single samples and upscaling of image-based analysis to high-content approaches. Simple segmentation algorithms of biological imagery are nowadays widely spread in biomedical research, but processing of complex sample structures, for example, variable sample compositions, cell shapes, and sizes, and rare events remains a difficult task. As there is no perfect method for image segmentation and fully automatic image analysis of complex content, we aimed to succeed by identification of unique and reliable features within the sample...
February 1, 2017: SLAS Discov
https://www.readbyqxmd.com/read/28345973/patient-satisfaction-with-clinicians-in-colorectal-2-week-wait-clinics
#10
Karen Cock, Bridie Kent
AIM: To determine if patient satisfaction is affected by the clinician (nurse or doctor), conducting the colorectal 2-week wait (2ww) clinics. METHODS: A prospective non-randomised comparative cohort study of 339 consecutive patients (divided by blind allocation into nurse-led (n=216) and doctor-led (n=123) cohorts) conducted over a 3-month period. Patient satisfaction in both cohorts was assessed by an adapted version of the Grogan et al validated patient satisfaction questionnaire...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28345838/ercc1-expression-in-metastatic-triple-negative-breast-cancer-patients-treated-with-platinum-based-chemotherapy
#11
Mohamed Ali EL Baiomy, Wagdi F El Kashef
Background: Possible targeted therapies for metastatic triple negative breast cancer (TNBC) include cytotoxic chemotherapy that causes interstrand breaks (platinum-based drugs). The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway, removing platinum-induced DNA adducts and contributing to cisplatin resistance. Detecting ERCC1 overexpression is important in considering treatment options for metastatic TNBC, including individualized approaches to therapy, and may facilitate improved responses or reduction of unnecessary toxicity...
February 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28345733/-hand-fine-motor-skills-and-use-of-both-hand-and-arm-in-subjects-after-a-stroke-a-systematic-review
#12
M Ostolaza, J Abudarham, S Dilascio, E Drault-Boedo, S Gallo, A Garcete, M Kramer, M Maiaru, A Mendelevich, M Modica, F Peralta, C Sanchez-Correa
INTRODUCTION: In clinical practice it is important to be able to assess the function of the upper limb of the patient who has suffered a stroke. There is currently no systemic review that could identify assessment tools for the 'fine use of the hand' and 'use of both hand and arm'. AIMS: Primary, to identify observational tools which can assess the fine use of the hand and the use of both hand and arm in patients with stroke sequels. Secondary, to analyze the bias risk in the included articles, describing and categorizing the clinical utility, validity and reliability...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28345678/laryngeal-manual-therapy-palpatory-evaluation-scale-a-preliminary-study-to-examine-its-usefulness-in-diagnosis-of-occupational-dysphonia
#13
Ewelina Woźnicka, Ewa Niebudek-Bogusz, Joanna Morawska, Justyna Wiktorowicz, Mariola Śliwińska-Kowalska
BACKGROUND: The aim of this study has been to assess the larynx and soft tissue around the vocal tract in a group of people with healthy voice, and in a group of patients with occupational dysphonia using the new laryngeal manual therapy palpatory evaluation scale (LMTPE). MATERIAL AND METHODS: The examinations were performed in a study (dysphonic) group of professional voice users who had developed voice disorders (N = 51) and in the control group of normophonic subjects (N = 50)...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28345523/a-practical-formula-for-determining-growth
#14
Çağrı Türkoz, Emine Kaygısız, Çağrı Ulusoy, Can Ateş
PURPOSE: We aimed to establish a practical method to evaluate skeletal age using cervical vertebrae. METHODS: The study consisted of hand-wrist and cephalometric radiographs of 324 subjects (167 girls, 157 boys; age range, 7.3-17.2 years). Skeletal ages of the subjects were calculated from hand-wrist radiographs, and cervical vertebral bodies were measured using cephalometric radiographs. A single formula based on C3 and C4 vertebral body heights with different coefficients for each gender was derived using ridge regression analysis...
March 27, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28345505/international-recognition-of-the-chronic-otitis-media-questionnaire-12
#15
S I Kosyakov, J V Minavnina, J S Phillips, M W Yung
OBJECTIVE: The Chronic Otitis Media Questionnaire 12 was developed initially in the UK to assess patient-reported health-related quality of life associated with chronic otitis media. This study aimed to determine whether this tool is applicable to the Russian population, which has a materially different healthcare system. METHOD: A total of 108 patients with different forms of chronic otitis media completed the Russian Chronic Otitis Media Questionnaire 12. RESULTS: The average Russian Chronic Otitis Media Questionnaire 12 score was 19...
March 27, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/28345494/adaptation-and-validation-of-the-alzheimer-s-disease-assessment-scale-cognitive-adas-cog-in-a-low-literacy-setting-in-sub-saharan-africa
#16
Stella-Maria Paddick, Aloyce Kisoli, Sarah Mkenda, Godfrey Mbowe, William Keith Gray, Catherine Dotchin, Adesola Ogunniyi, John Kisima, Olaide Olakehinde, Declare Mushi, Richard William Walker
OBJECTIVE: This study aimed to assess the feasibility of a low-literacy adaptation of the Alzheimer's Disease Assessment Scale - Cognitive (ADAS-Cog) for use in rural sub-Saharan Africa (SSA) for interventional studies in dementia. No such adaptations currently exist. METHODS: Tanzanian and Nigerian health professionals adapted the ADAS-Cog by consensus. Validation took place in a cross-sectional sample of 34 rural-dwelling older adults with mild/moderate dementia alongside 32 non-demented controls in Tanzania...
March 27, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28345467/mitochondrial-dna-alteration-in-primary-and-metastatic-colorectal-cancer-different-frequency-and-association-with-selected-clinicopathological-and-molecular-markers
#17
Britta Kleist, Thuja Meurer, Micaela Poetsch
This study attempts to determine whether primary tumor tissue could reliably represent metastatic colorectal cancer in therapy-guiding analysis of mitochondrial microsatellite instability. Therefore, we investigated the concordance of microsatellite instability in D310, D514, and D16184 (mitochondrial DNA displacement loop), and its association with selected clinical categories and KRAS/NRAS/BRAF/PIK3CA/TP53 mutation status between primary and metastatic colorectal cancer tissue from 119 patients. Displacement loop microsatellite instability was significantly more frequently seen in lymph node metastases (53...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28345169/alcohol-use-from-adolescence-through-early-adulthood-an-assessment-of-measurement-invariance-by-age-and-gender
#18
Jessica N Fish, Amanda M Pollitt, John E Schulenberg, Stephen T Russell
BACKGROUND AND AIMS: Studies on alcohol use and related constructs rarely test for measurement invariance to assess the reliability and validity of measures of alcohol use across different subpopulations of interest or ages. This failure to consider measurement invariance may result in biased parameter estimates and inferences. This study aimed to test measurement invariance of alcohol use across gender and age using a US-nationally representative sample to inform future longitudinal studies assessing alcohol use...
March 26, 2017: Addiction
https://www.readbyqxmd.com/read/28345042/human-genetic-and-metabolite-variation-reveals-that-methylthioadenosine-is-a-prognostic-biomarker-and-an-inflammatory-regulator-in-sepsis
#19
Liuyang Wang, Emily R Ko, James J Gilchrist, Kelly J Pittman, Anna Rautanen, Matti Pirinen, J Will Thompson, Laura G Dubois, Raymond J Langley, Sarah L Jaslow, Raul E Salinas, D Clayburn Rouse, M Arthur Moseley, Salim Mwarumba, Patricia Njuguna, Neema Mturi, Thomas N Williams, J Anthony G Scott, Adrian V S Hill, Christopher W Woods, Geoffrey S Ginsburg, Ephraim L Tsalik, Dennis C Ko
Sepsis is a deleterious inflammatory response to infection with high mortality. Reliable sepsis biomarkers could improve diagnosis, prognosis, and treatment. Integration of human genetics, patient metabolite and cytokine measurements, and testing in a mouse model demonstrate that the methionine salvage pathway is a regulator of sepsis that can accurately predict prognosis in patients. Pathway-based genome-wide association analysis of nontyphoidal Salmonella bacteremia showed a strong enrichment for single-nucleotide polymorphisms near the components of the methionine salvage pathway...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28344810/novel-biomarkers-for-the-detection-of-prostate-cancer
#20
Niels Asger Jakobsen, Freddie Charles Hamdy, Richard John Bryant
Prostate-specific antigen (PSA) is widely used as a biomarker in the detection of prostate cancer and for decision making regarding treatment options, response to therapy, and clinical follow-up. Despite its widespread use, it is well recognised that PSA has suboptimal performance as a screening tool due to poor specificity, resulting in high negative biopsy rates and potential 'over-diagnosis' and 'over-treatment' of clinically insignificant cancers. In particular, PSA does not reliably distinguish either cancer from benign prostatic conditions, or 'clinically significant' from 'indolent cancers', and it is inaccurate in predicting disease burden and response to treatment...
December 2016: Journal of Clinical Urology
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