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https://www.readbyqxmd.com/read/28545238/epigenetic-strategies-to-boost-cancer-immunotherapies
#1
REVIEW
Maria J Barrero
Recently, immunotherapeutic approaches have shown impressive responses in a subset of cancer patients. However, the rate of success is low and a large percentage of treated patients do not experience clinical benefits. Therefore, additional strategies are needed to improve responses and select responsive patients. Emerging data suggest that epigenetic drugs can improve the responses to immunotherapy. Understanding the mechanisms of resistance to immunotherapy and the epigenetic events that take place during immune evasion is critical to providing a rational combined use of immunotherapies and epigenetic drugs...
May 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28545230/nanog-plays-a-hierarchical-role-in-the-transcription-network-regulating-the-pluripotency-and-plasticity-of-adipose-tissue-derived-stem-cells
#2
Maria Pitrone, Giuseppe Pizzolanti, Laura Tomasello, Antonina Coppola, Lorenzo Morini, Gianni Pantuso, Romina Ficarella, Valentina Guarnotta, Sebastio Perrini, Francesco Giorgino, Carla Giordano
The stromal vascular cell fraction (SVF) of visceral and subcutaneous adipose tissue (VAT and SAT) has increasingly come into focus in stem cell research, since these compartments represent a rich source of multipotent adipose-derived stem cells (ASCs). ASCs exhibit a self-renewal potential and differentiation capacity. Our aim was to study the different expression of the embryonic stem cell markers NANOG (homeobox protein NANOG), SOX2 (SRY (sex determining region Y)-box 2) and OCT4 (octamer-binding transcription factor 4) and to evaluate if there exists a hierarchal role in this network in ASCs derived from both SAT and VAT...
May 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28545201/treatment-experiences-of-women-with-reproductive-cancers-in-odisha-india-a-qualitative-exploration-of-enablers-and-barriers
#3
Sanghamitra Pati, Abhimanyu Singh Chauhan, Sandeep Mahapatra, Sabita Nayak, Sukdev Nayak, David Weller
Introduction: Cancer continues to be a major menace to our Indian society notwithstanding significant progress in diagnosis and treatment. In India cancer mortality rates in women are high compared to other countries, despite efforts to improve survival through the development of effective detection techniques and increased numbers of viable treatment options. Indian women’s advanced stage of disease at diagnosis is largely attributable to delay in seeking treatment. The present qualitative inquiry was conducted with the aim of capturing the treatment experiences of patients with gynecology cancer at a tertiary care hospital and understanding the barriers, enablers, stress and apprehension they experience during the treatment phases...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545107/predictive-factors-of-right-paraesophageal-lymph-node-metastasis-in-papillary-thyroid-carcinoma-single-center-experience-and-meta-analysis
#4
Young Min Park, Sang Min Lee, Dong Won Kim, Sung-Chan Shin, Byung-Joo Lee
BACKGROUND: We performed this retrospective study to identify predictors of right paraesophageal lymph node metastasis, and reviewed previous studies related to this topic. METHODS: Between June 2005 and March 2015, 1107 patients were diagnosed with papillary thyroid carcinoma and underwent surgery at Pusan National University Hospital. RESULTS: Right paraesophageal lymph node metastasis was observed in 171 (15.4%) patients. Multivariate analyses showed that the risk of right paraesophageal metastasis was significantly associated with tumor size, location, a higher number of metastatic central lymph nodes, and lateral lymph node metastasis...
2017: PloS One
https://www.readbyqxmd.com/read/28545096/vascular-disease-in-copd-systemic-and-pulmonary-expression-of-parc-pulmonary-and-activation-regulated-chemokine
#5
Mariana Muñoz-Esquerre, Elisabet Aliagas, Marta López-Sánchez, Ignacio Escobar, Daniel Huertas, Rosa Penín, Jordi Dorca, Salud Santos
INTRODUCTION: The role of Pulmonary and Activation-Regulated Chemokine (PARC) in the physiopathology of Chronic Obstructive Pulmonary Disease (COPD) is not fully understood. The aim of the present study is to analyze the expression of PARC in lung tissue and its relationship with the vascular remodeling of the systemic and pulmonary arteries of COPD subjects. METHODS: To achieve this objective, protein and gene expression experiments, together with ELISA assays, were performed on the lung tissue, intercostal arteries and serum samples from COPD patients, non-obstructed smokers (NOS) and never-smokers (NS)...
2017: PloS One
https://www.readbyqxmd.com/read/28545009/mediating-role-of-borderline-personality-disorder-traits-in-the-effects-of-childhood-maltreatment-on-suicidal-behaviour-among-mood-disorder-patients
#6
K I Aaltonen, T Rosenström, I Baryshnikov, B Karpov, T Melartin, K Suominen, M Heikkinen, P Näätänen, M Koivisto, G Joffe, E Isometsä
BACKGROUND: Substantial evidence supports an association between childhood maltreatment and suicidal behaviour. However, few studies have examined factors mediating this relationship among patients with unipolar or bipolar mood disorders. METHODS: Depressive disorder and bipolar disorder (ICD-10-DCR) patients (n=287) from the Helsinki University Psychiatric Consortium (HUPC) Study were surveyed on self-reported childhood experiences, current depressive symptoms, borderline personality disorder traits, and lifetime suicidal behaviour...
April 8, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28544919/risk-factors-for-patient-reported-errors-during-cancer-follow-up-results-from-a-national-survey-in-denmark
#7
Anne Hjøllund Christiansen, Henriette Lipczak, Janne Lehmann Knudsen, Anne Mette Tranberg Kejs
Due to an increased cancer survival, more cancer patients are referred to follow-up after primary treatment. Knowledge of patient safety during follow-up is sparse. OBJECTIVE: To examine patient-reported errors during cancer follow-up and identify factors associated with errors. DESIGN: A national survey on cancer patients' experiences of treatment and aftercare was conducted in 2012, about two years following cancer diagnosis (N=6914). Associations between patient-reported errors during follow-up and covariates were examined using multiple logistic regression...
May 22, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28544841/transcatheter-valve-in-valve-implantation-failing-tricuspid-bioprosthesis-in-a-patient-with-ebstein%C3%A2-s-anomaly
#8
Pedro A Villablanca, Aman M Shah, David F Briceno, Ali N Zaidi, Mei Chau, Mario J Garcia, David Slovut, Cynthia Taub
Transcatheter valve-in-valve (VIV) implantation has been recently proposed as an alternative to surgical reoperative aortic valve replacement in patients with a failing aortic bioprosthesis. Experience with transcatheter VIV implantation at other valve positions is very limited. Herein is reported the case of an 18-year-old man with Ebstein's anomaly and severe tricuspid valve (TV) regurgitation status after bioprosthetic valve replacement, who developed new dyspnea on exertion three years after the initial valve replacement...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544831/aortic-root-surgery-in-marfan-syndrome-medium-term-outcome-in-a-single-center-experience
#9
Christine H Attenhofer Jost, Heidi M Connolly, Christopher G Scott, Naser M Ammash, Juan M Bowen, Hartzell V Schaff
BACKGROUND: The study aim was to analyze the authors' experience with aortic root surgery in Marfan syndrome (MFS), and to expand the surgical outcome data of patients meeting the Ghent criteria (Marfan registry). METHODS: Analyses were performed of data acquired from MFS patients (who met the Ghent criteria), including an aortic root surgery and Kaplan-Meier survival. RESULTS: Between April 2004 and February 2012, a total of 59 MFS patients (mean age at surgery 36 ± 13 years) underwent 67 operations for aortic root aneurysm (n = 52), aortic valve (AV) regurgitation (n = 15), acute aortic dissection (n = 2), and/or mitral valve (MV) regurgitation resulting from MV prolapse (n = 7)...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544826/preoperative-computed-tomography-scan-analysis-of-interleaflets-triangles-to-guide-aortic-root-repair-procedures
#10
Claudia Romagnoni, Andrea Mangini, Monica Contino, Rubina Rosa, Sonia Ippolito, Guido Gelpi, Carlo Antona
BACKGROUND: Stabilization of the ventriculo-aortic junction (VAJ) is gaining increasing interest in the context of aortic valve repair, since its dilation is a well-recognized risk factor for long-term repair failure. Interleaflets triangles are key elements of the VAJ, but cannot be completely visualized using echocardiography. A three-dimensional (3D) reconstruction of electrocardiogram-triggered computed tomography (CT) scan images allows an analysis of the real dimensions and anatomic characteristics of the subcommissural triangles...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28544809/robotic-radiosurgery-of-head-and-neck-paragangliomas-a-single-institution-experience
#11
İlker Tosun, Banu Atalar, Bilgehan Şahin, Görkem Güngör, Gökhan Aydin, Bülent Yapici, Enis Özyar
AIM: CyberKnife(®) is a robotic stereotactic radiotherapy system. The aim of this study is to evaluate the effectiveness and the safety of CyberKnife(®) on treating head and neck paragangliomas and to report our results. METHODS: Between March 2009 and June 2014, 12 patients with head and neck paragangliomas have been referred to our clinic: in three cases had jugular paragangliomas, five cases had carotid body paragangliomas and three cases had tympanic paragangliomas...
May 24, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28544805/a-comparison-of-attitudes-to-laryngeal-cancer-treatment-outcomes-a-time-trade-off-study
#12
David W Hamilton, Ami Pedersen, Hannah Blanchford, Janneke E Bins, Peter McMeekin, Richard Thomson, Vinidh Paleri, Janet A Wilson
DESIGN: Time trade-off choice experiment. SETTING: Two large head and neck cancer centres. PARTICIPANTS: Patients who have received treatment for head and neck cancer and members of the head and neck cancer multidisciplinary team. MAIN OUTCOME MEASURES: Participants were asked to rank the outcome scenarios, assign utility values using time trade-off and rate the importance of survival on treatment choice. RESULTS: 49 head and neck cancer patients and 73 staff members were recruited...
May 19, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28544749/role-of-treatment-on-the-development-of-secondary-malignancies-in-patients-with-essential-thrombocythemia
#13
Cristina Santoro, Isabella Sperduti, Roberto Latagliata, Erminia Baldacci, Barbara Anaclerico, Giuseppe Avvisati, Massimo Breccia, Francesco Buccisano, Michele Cedrone, Giuseppe Cimino, Cinzia De Gregoris, Marianna De Muro, Ambra Di Veroli, Sabrina Leonetti Crescenzi, Marco Montanaro, Enrico Montefusco, Raffaele Porrini, Angela Rago, Antonio Spadea, Francesca Spirito, Nicoletta Villivà, Alesssandro Andriani, Giuliana Alimena, Maria Gabriella Mazzucconi
Aim of this study is to explore the role of different treatments on the development of secondary malignancies (SMs) in a large cohort of essential thrombocythemia (ET) patients. We report the experience of a regional cooperative group in a real-life cohort of 1026 patients with ET. We divided our population into five different groups: group 0, no treatment; group 1, hydroxyurea (HU); group 2, alkylating agents (ALK); group 3, ALK + HU sequentially or in combination; and group 4, anagrelide (ANA) and/or α-interferon (IFN) only...
May 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28544707/the-use-of-co2-laser-in-skin-complications-following-baha-implantation-our-experience-in-the-eight-patients
#14
Maciej Sokola, Katarzyna Malec, Pawel Brzewski, Pawel Dobosz
1 Skin reactions are the most common complications after BAHA implantation. 2 The excess of soft tissue leads to inability to tack the hearing ad to the abutment which prevents the effective use of sound processor. 3 This is a prospective case series of 8 patients with skin overgrowth around the BAHA abutments treated with CO2 laser. 4 This case-series suggest that CO2 laser is safe and easy method for the treatment of the skin overgrowth around the BAHA abutment. 5 This is the first case series presentation of the CO2 laser surgery for treatment of the skin overgrowth around the abutment of BAHA This article is protected by copyright...
May 22, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28544682/hypertension-induced-by-tyrosine-kinase-inhibitors-for-the-treatment-of-renal-cell-carcinoma-in-hemodialysis-patients-a-single-center-experience-and-review-of-the-literature
#15
Kentaro Nakai, Hideki Fujii, Keiji Kono, Shunsuke Goto, Shinichi Nishi
Malignancy is a major cause of mortality in dialysis patients. Although molecular-targeted anticancer drugs, including tyrosine-kinase inhibitors, are used for advanced renal cell carcinoma treatment, there are few reports on their effectiveness and safety in dialysis patients. Renal cell carcinoma dialysis patients treated at our hospital from 2010 to 2013 participated in this study. Thirteen patients were treated with tyrosine-kinase inhibitors and 15 patients with surgery only (control group). During treatment, blood pressure changes and dry weight reduction tended to be greater in the tyrosine-kinase inhibitor group than in controls...
May 23, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28544609/global-circular-rna-expression-profile-of-human-gastric-cancer-and-its-clinical-significance
#16
Yongfu Shao, Jinyun Li, Rongdan Lu, Tianwen Li, Yunben Yang, Bingxiu Xiao, Junming Guo
Circular RNAs (circRNAs) are a new class of noncoding RNAs. However, the expression profile and clinical significance of circRNAs in human gastric cancer is unclear. The global circRNA expression profile in human gastric cancer was measured by circRNA microarray. Hsa_circ_0014717, one of the most downregulated circRNAs in microarray, was selected as a targeted circRNA to explore its levels in gastric tissues and gastric juice. Freeze-thaw experiment and incubation experiment confirmed the stability of gastric juice circRNAs...
May 23, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28544500/non-communicable-diseases-and-hiv-care-and-treatment-models-of-integrated-service-delivery
#17
REVIEW
Malia Duffy, Bisola Ojikutu, Soa Andrian, Elaine Sohng, Thomas Minior, Lisa R Hirschhorn
OBJECTIVES: Non-communicable diseases (NCD) are a growing cause of morbidity in low-income countries including in people living with Human Immunodeficiency Virus (HIV). Integration of NCD and HIV services can build upon experience with chronic care models from HIV programs. We describe models of NCD and HIV integration, challenges, and lessons learned. METHODS: Literature review of articles on integrated NCD and HIV programs in low-income countries and key informant interviews with leaders of identified integrated NCD and HIV programs...
May 24, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28544493/-it-s-a-fight-to-get-anything-you-need-accessing-care-in-the-community-from-the-perspectives-of-people-with-multimorbidity
#18
Julia W Ho, Kerry Kuluski, Jennifer Im
BACKGROUND: There is a growing interest in redesigning health-care systems to better manage the increasing numbers of people with multimorbidity. Knowing how patients experience health-care delivery and what they need from the health-care system are critical pieces of evidence that can be used to guide health system reforms. OBJECTIVE: The purpose of this study was to understand the challenges patients with multimorbidity face in accessing care in the community, and the implications for patients and their families...
May 24, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28544470/patients-help-seeking-experiences-and-delaying-in-breast-cancer-diagnosis-a-qualitative-study
#19
Mariko Oshiro, Midori Kamizato
AIM: To identify the influencing factors in help-seeking behavior by comparing delayers with non-delayers in Japanese female patients with breast cancer. METHODS: This is a descriptive qualitative study. A total of 21 female patients with breast cancer (nine delayers and 12 non-delayers) who were at least 3 months to 5 years postdiagnosis were recruited from two hospitals in Okinawa, Japan. Semistructured interviews were carried out and the results were analyzed by using a qualitative inductive approach...
May 23, 2017: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28544391/the-experience-sampling-method-as-an-mhealth-tool-to-support-self-monitoring-self-insight-and-personalized-health-care-in-clinical-practice
#20
Jim van Os, Simone Verhagen, Anne Marsman, Frenk Peeters, Maarten Bak, Machteld Marcelis, Marjan Drukker, Ulrich Reininghaus, Nele Jacobs, Tineke Lataster, Claudia Simons, Richel Lousberg, Sinan Gülöksüz, Carsten Leue, Peter C Groot, Wolfgang Viechtbauer, Philippe Delespaul
BACKGROUND: The experience sampling method (ESM) builds an intensive time series of experiences and contexts in the flow of daily life, typically consisting of around 70 reports, collected at 8-10 random time points per day over a period of up to 10 days. METHODS: With the advent of widespread smartphone use, ESM can be used in routine clinical practice. Multiple examples of ESM data collections across different patient groups and settings are shown and discussed, varying from an ESM evaluation of a 6-week randomized trial of mindfulness, to a twin study on emotion dynamics in daily life...
May 23, 2017: Depression and Anxiety
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