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https://www.readbyqxmd.com/read/28914594/salivary-neuropeptides-stress-and-periodontitis
#1
Hady Haririan, Oleh Andrukhov, Michael Böttcher, Eleonore Pablik, Gernot Wimmer, Andreas Moritz, Xiaohui Rausch-Fan
BACKGROUND: Scientific evidence for psychological stress as a risk factor for periodontitis is fragmentary relying mostly on either questionnaire-based or biomarker studies. The aim of this study was to investigate Brain Derived Neurotrophic Factor, Substance P, Vasoactive Intestinal Peptide (VIP), Neuropeptide Y (NPY), Calcitonin Gene Related Peptide and Adrenomedullin as well as cortisol in saliva and serum in periodontal health and disease combined with different aspects of stress and possible associations with clinical parameters...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28894772/epidemiologic-features-and-outcomes-of-caustic-ingestions-a-10-year-cross-sectional-study
#2
Athena Alipour Faz, Fahimeh Arsan, Hassan Peyvandi, Mahbobeh Oroei, Omid Shafagh, Maryam Peyvandi, Maryam Yousefi
INTRODUCTION: Caustic ingestions are among the most prevalent causes of toxic exposure. The present 10-year survey aimed to evaluate the epidemiologic features and outcomes of caustic ingestion cases presenting to emergency department. METHODS: This is a retrospective cross-sectional study on patients who were admitted to a referral toxicology center during 2004 to 2014, following caustic ingestion. Baseline characteristics, presenting chief complaint, severity of mucosal injury, complications, imaging and laboratory findings as well as outcomes (need for ICU admission, need for surgery, mortality) were recorded, reviewing patients' medical profile, and analyzed using SPSS 22...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28887235/impact-of-n-methylation-of-the-substance-p-1-7-amide-on-anti-allodynic-effect-in-mice-after-peripheral-administration
#3
Anna Skogh, Anna Lesniak, Fabienne Z Gaugaz, Richard Svensson, Gunnar Lindeberg, Rebecca Fransson, Fred Nyberg, Mathias Hallberg, Anja Sandström
Substance P 1-7 (SP1-7, Arg(1)-Pro(2)-Lys(3)-Pro(4)-Gln(5)-Gln(6)-Phe(7)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP). This heptapeptide often opposes the effects of the mother peptide. Hence, SP1-7 is having anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects in experimental models. Despite all encouraging properties of SP1-7 its exact mode of action has not yet been elucidated which has hampered further development of this heptapeptide in drug discovery...
September 5, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28887225/substance-p-and-neurotensin-in-the-limbic-system-their-roles-in-reinforcement-and-memory-consolidation
#4
REVIEW
L Lénárd, K László, E Kertes, T Ollmann, L Péczely, A Kovács, V Kállai, O Zagorácz, R Gálosi, Z Karádi
Substance P (SP) and neurotensin (NT) are neuropeptides isolated in the periphery and in the central nervous system. They are involved in various regulatory processes in the gastrointestinal tract, in the circulatory and respiratory systems, kidney and endocrine system. In addition to the peripheral effects, SP and NT act as neurotransmitters and neuromodulators in the central nervous system, regulating various behavioural actions, such as general and motor activity, pain, food and water intake, anxiety, reward/reinforcement and memory consolidation...
September 5, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28884307/the-role-of-the-transient-receptor-potential-ankyrin-type-1-trpa1-channel-in-migraine-pain-evaluation-in-an-animal-model
#5
Chiara Demartini, Cristina Tassorelli, Anna Maria Zanaboni, Germana Tonsi, Oscar Francesconi, Cristina Nativi, Rosaria Greco
BACKGROUND: Clinical and experimental studies have pointed to the possible involvement of the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this study, we aimed to further investigate the role of these channels in an animal model of migraine using a novel TRPA1 antagonist, ADM_12, as a probe. METHODS: The effects of ADM_12 on nitroglycerin-induced hyperalgesia at the trigeminal level were investigated in male rats using the quantification of nocifensive behavior in the orofacial formalin test...
September 7, 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28882971/mouse-hemokinin-1-decapeptide-subjected-to-a-brain-specific-post-translational-modification
#6
Georgia Deliconstantinos, Stephen Barton, Mikhail Soloviev, Nigel Page
BACKGROUND/AIM: The tachykinin mouse hemokinin-1, expressed by the mouse Tac4 gene, produces either analgesia or nociception, interacting with the neurokinin 1 receptor. TAC4 precursor processing is not identical to the processing of the TAC1 precursor, for the release of substance P (amidated undecapeptide). The characterization of the mouse hemokinin-1 sequence was required. MATERIALS AND METHODS: We developed anti-tachykinin-specific antibodies for the immunoaffinity purification of tachykinins...
September 2017: In Vivo
https://www.readbyqxmd.com/read/28873259/increased-enteric-glial-cells-in-proximal-margin-of-resection-is-associated-with-postoperative-recurrence-of-crohn-s-disease
#7
Yi Li, Yuanyuan Ge, Weiming Zhu, Jianfeng Gong, Lei Cao, Zhen Guo, Lili Gu, Jieshou Li
BACKGROUND AND AIM: The enteric nervous system can amplify or modulate intestinal inflammation through secretion of neuropeptides, and enteric glial cells has been implicated in the pathophysiology of Crohn's disease. The goal of the study was to search for an association between the density of neurons, neuropeptides, as well as enteric glial cells and postoperative recurrence. METHODS: The ileal proximal uninflamed section from ileocolonic sample was studied using immunohistochemistry with antibodies directed against vasoactive intestinal polypeptide (VIP), substance P (SP), neuron-specific enolase (NES), and the glial marker protein S100...
September 5, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28871952/-up-regulated-expression-of-nk1r-in-eosinophil-enriched-blood-cells-from-patients-with-chronic-spontaneous-urticaria
#8
Wei Wang, Huiyun Zhang, Wenjiao Zheng, Shaoheng He
Objective To investigate the expressions of substance P (SP) and neurokinin-1 receptor (NK1R) in eosinophil-enriched blood cells from patients with chronic spontaneous urticaria (CSU). Methods Peripheral venous blood samples were collected from patients with CSU and healthy controls (HCs), and then stimulated with crude extracts of Artemisia pollen, dust mite, and Platanus pollen (all at concentrations of 0.1 and 1.0 μg/mL). The expressions of SP and NK1R in eosinophil-enriched blood cells were detected by flow cytometry...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28866875/substance-p-and-calcitonin-gene-related-peptide-in-the-glands-of-external-auditory-canal-skin
#9
Yong Joo Yoon, Jin Yoon, Eun Jung Lee, Jong Seung Kim
Objectives.: The earwax (cerumen) that covers external auditory canal (EAC) skin contains a mixture of ceruminous and sebaceous gland substances, such as lipids, peptides, and proteins. The components secreted from the ceruminous gland that is a modified sweat gland form cerumen and contain several antimicrobial factors. Since substance P (SP) and calcitonin gene-related peptide (CGRP), known as a secretagogue, have been found in sweat glands, our purpose was to determine the expression of SP and CGRP in the glands of EAC skin...
September 5, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/28866052/sleep-inducing-effect-of-substance-p-cholera-toxin-a-subunit-in-mice
#10
Mark R Zielinski, Dmitry Gerashchenko
Evidence indicates that the neuropeptide substance P (SP) can act through neurokinin receptors to alter sleep and/or non-rapid eye movement (NREM) sleep slow-wave activity. Consequently, drugs acting on SP receptors could potentially be used as a novel treatment for sleep-related disorders. In the present study, we used SP conjugated with cholera toxin A subunit (SP-CTA), which enhances its duration of activity on SP receptor-expressing cells, to determine the effects of selectively activating SP receptor-expressing brain cells on sleep regulation in mice...
September 1, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28864032/in-memory-of-norman-bowery-1944-2016
#11
REVIEW
David G Trist, Terry P Kenakin, Thomas P Blackburn
This article is in memory of Professor Norman Bowery (1944-2016). Norman was a pharmacologist who spent most of his career researching the pharmacology of γ-aminobutyric acid (GABA). He discovered a novel metabotropic receptor subtype, GABAB, that is pharmacologically, and structurally different from the original ionotropic receptor now designated as GABAA. In his research he also studied the neurotransmitters glutamate and substance P, two molecules whose release in parts of the spinal cord is inhibited by baclofen a GABAB receptor agonist...
August 29, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28859248/allergic-fc%C3%AE%C2%B5ri-and-pseudo-allergic-mrgprx2-triggered-mast-cell-activation-routes-are-independent-and-inversely-regulated-by-scf
#12
Magda Babina, Sven Guhl, Metin Artuc, Torsten Zuberbier
While allergic mast cell (MC) degranulation occurs by FcεRI-aggregation and varies in strength among subjects, the analogous pseudo-allergic route was recently uncovered to proceed via MRGPRX2. Here, we examine inter-individual variability in skin MC responses to FcεRI-triggering versus those evoked by MRGPRX2. While population-based variability is comparable between the routes, FcεRI- and MRGPRX2-stimulated pathways are completely independent from each other, and responsiveness to one has therefore no predictive value for the other...
August 31, 2017: Allergy
https://www.readbyqxmd.com/read/28858902/huntington-mice-demonstrate-diminished-pain-response-in-inflammatory-pain-model
#13
Ya-Chi Lin, Hung-Tsung Hsiao, Sheng-Nan Wu, Yen-Chin Liu
BACKGROUND: Huntington disease (HD) affects the nervous system and leads to mental and motor dysfunction. Previous studies have shown that HD is caused by the exon 1 region of the huntingtin (HTT) gene having expanded CAG trinucleotide repeats. However, few studies have focused on the relationship between HD and pain. The purpose of this study is to investigate the relationship between HD and pain response. METHODS: We used clinical similar transgenic HD mice carrying a mutant HTT exon 1 containing 84 CAG trinucleotide repeats to evaluate the relationship between HD and pain...
August 30, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28853492/role-of-substance-p-and-its-receptor-neurokinin-1-in-chronic-prurigo-a-randomized-proof-of-concept-controlled-trial-with-topical-aprepitant
#14
Tatevik Ohanyan, Nicole Schoepke, Stefan Eirefelt, Gert Hoey, Witte Koopmann, Tomasz Hawro, Marcus Maurer, Martin Metz
Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients with chronic prurigo. SP and NK1R were increased, compared with controls, in the serum and in lesional vs. non-lesional skin of the patients, respectively. Aprepitant, in a randomized, placebo-controlled, split-sided, double-blind trial, reduced the intensity of pruritus as assessed by visual analogue scale by > 50% from baseline to day 28 (-35...
August 30, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28852030/the-association-between-substance-p-and-white-matter-integrity-in-medication-naive-patients-with-major-depressive-disorder
#15
Eunsoo Won, June Kang, Sunyoung Choi, Aram Kim, Kyu-Man Han, Ho-Kyoung Yoon, Su-Hee Cho, Woo-Suk Tae, Min-Soo Lee, Sook-Haeng Joe, Yong-Ku Kim, Byung-Joo Ham
Substance P (SP) has been implicated in major depressive disorder (MDD), with SP antagonists being studied as potential antidepressants. Although impaired neural plasticity is considered a key mechanism in MDD pathophysiology, the association between SP and brain structural changes in depression has not been investigated. We investigated the correlations between SP levels and white matter (WM) integrity in 42 medication-naive patients with MDD and 57 healthy controls (HCs). Plasma levels of SP were determined, and diffusion tensor imaging (DTI) was performed to investigate microstructural changes in WM tracts...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851567/association-of-down-regulation-of-calcitonin-gene-related-peptide-and-substance-p-with-increase-of-myocardial-vulnerability-in-diabetic-neuropathic-rats
#16
Tu-Ping Li, Zheng Guo, Chao-Jie Liu, Tao Sun, Lu Chen, Xin Zhao
Diabetic patients present high co-morbidities of neuropathy and severer consequences of coronary heart disease. But the pathological mechanism is still unclear. Here we investigated a potential association of diabetic impairment of sensory nerves with increase of vulnerability of myocardium in acute myocardial ischemia/reperfusion. A rat model of diabetes mellitus was induced by high fat and sugar diet plus a small dose of streptozotocin. Impairment of sensory nerves was evaluated by measurement of changes in tail flick latency to noxious thermal stimulation and calcitonin gene-related peptide (CGRP) and substance P (SP) in the dorsal root ganglia (DRG) and the myocardium of the heart were examined...
August 26, 2017: Peptides
https://www.readbyqxmd.com/read/28842601/a-neuropeptide-substance-p-directly-induces-tissue-repairing-m2-like-macrophages-by-activating-the-pi3k-akt-mtor-pathway-even-in-the-presence-of-ifn%C3%AE
#17
Ji Eun Lim, Eunkyung Chung, Youngsook Son
Macrophage polarization plays an important role in tissue damage and repair. In this study, we show that Substance-P (SP) can directly induce M2 polarization of inflammatory macrophages. SP induced the differentiation of GM-CSF-differentiated pro-inflammatory macrophages into alternatively activated phagocytic M2 like macrophages (M2(SP)) through direct activation of the PI3K/Akt/mTOR/S6kinase pathway and induction of Arginase-1, CD163, and CD206, all of which were nullified by pretreatment with the neurokinin-1 receptor (NK-1R) antagonist RP67580 and specific signaling pathway inhibitors...
August 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842244/substance-p-receptor-in-the-rat-indusium-griseum-during-postnatal-development
#18
Paolo Barbaresi
The presence of substance P (SP) receptor (Neurokinin-1 receptor, NK1R) in the indusium griseum (IG) and anterior hippocampal continuation (AHC) during postnatal development was studied by immunocytochemistry (ICC). NK1R-immunopositive neurons (NK1RIP-n) first appeared in both areas on postnatal day (P) 5. From P5 onward, their distribution pattern was adult-like. In sagittal sections NK1RIP-n formed a narrow strip of neurons and dendrites that were located over the corpus callosum (cc); in coronal sections they were found in a roughly triangular area at the base of the cingulate cortex (Cg) on the dorsal surface of the cc...
August 22, 2017: Neuroscience Research
https://www.readbyqxmd.com/read/28840571/drunkorexia-an-emerging-trend-in-young-adults
#19
Matteo Lupi, Giovanni Martinotti, Massimo Di Giannantonio
OBJECTIVE: Several studies demonstrated an association between alcohol consumption and unhealthy food habits. Particularly, in young adults it has been observed the tendency to use extreme forms of weight control as a way to compensate planned binge drinking. METHOD: A questionnaire was administered to a sample of 4275 healthy subjects (43.9% males; 56.1% females), aged between 18 and 26 (mean age 22.04). The survey investigated socio-economic characteristics, drinking habits with a specific focus on binge consumption, abnormal eating behaviours and psychoactive substance use...
August 24, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28833499/manifestation-of-atopic-dermatitis-like-skin-in-tncb-induced-nc-nga-mice-is-ameliorated-by-topical-treatment-of-substance-p-possibly-through-blockade-of-allergic-inflammation
#20
Hyeongwon Choi, Dong-Jin Kim, Seungwoo Nam, Sunki Lim, Jae-Sung Hwang, Ki Sook Park, Hyun Sook Hong, Min Kyung Shin, Eunkyung Chung, Youngsook Son
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by intense pruritus and eczematous lesion. In this study, topically applied substance P (SP) significantly alleviated AD-like clinical symptoms in 2, 4, 6-trinitrochlorobenzene (TNCB)-induced dermatitis in NC/Nga mice. This effect was nullified by pre-treatment of the neurokinin-1 receptor (NK-1R) antagonist CP99994. SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and thymic stromal lymphopoietin (TSLP), in AD-like skin lesions and decreased the levels of IgE and thymus and activation-regulated chemokine in serum...
August 20, 2017: Experimental Dermatology
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