keyword
MENU ▼
Read by QxMD icon Read
search

"substance P"

keyword
https://www.readbyqxmd.com/read/28430617/estrogen-receptors-involvement-in-intervertebral-discogenic-pain-of-the-elderly-women-colocalization-and-correlation-with-the-expression-of-substance-p-in-nucleus-pulposus
#1
Xiao-Xing Song, Sheng Shi, Zhen Guo, Xin-Feng Li, Bu-Wei Yu
Estrogenic modulation of pain is an exceedingly complex phenomenon. However, whether estrogen is involved in discogenic low back pain still remains unclear. Here, immunoreactivity staining technique was used to examine the expression level of the estrogen receptors (ERα and ERβ) and a pain related neuropeptide, Substance P in the lumbar intervertebral discs to analyze the relationship between the ERs and Substance P. Nucleus pulposus tissues of 23 elderly female patients were harvested during spinal surgeries and made to detect the immunoreactivity staining of ERα, ERβ and Substance P...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424793/a-model-based-meta-analysis-evaluating-gender-differences-on-blood-flow-responses-to-brachial-artery-infusions-of-acetylcholine-albuterol-atp-bradykinin-estradiol-glyceryl-trinitrate-l-nmma-nevibolol-norepinephrine-sodium-nitroprusside-substance-p-and-verapamil
#2
Andy R Eugene
INTRODUCTION: Numerous studies have emerged over the course of several decades describing the properties of drugs eliciting vasodilatory or vasoconstrictor responses in the human vasculature. During drug development, decisions to move forward with testing with a new chemical entity are very costly. To fund or not to fund development, go or no-go, decisions are often limited by efficacy comparisons with the current products on the market. The primary aim of this paper is to use dose-response modeling and simulations to quantify differences in blood flow to Acetylcholine, Albuterol, ATP, Bradykinin, 17β-Estradiol, Glyceryl Trinitrate, L-NMMA, Nevibolol, Norepinephrine, Sodium Nitroprusside, Substance P, and Verapamil...
June 2016: MEDtube Science
https://www.readbyqxmd.com/read/28424060/effects-of-a-combination-treatment-of-kd5040-and-l-dopa-in-a-mouse-model-of-parkinson-s-disease
#3
Sora Ahn, Taek-Jin Song, Seong-Uk Park, Songhee Jeon, Jongpil Kim, Joo-Young Oh, Jaehwan Jang, Sanhwa Hong, Min-A Song, Hye-Seoung Shin, Young-Rim Jung, Hi-Joon Park
BACKGROUND: Although the dopamine precursor L-3, 4-dihydroxyphenylalanine ( l -dopa) remains the gold standard pharmacological therapy for patients with Parkinson's disease (PD), long-term treatment with this drug has been known to result in several adverse effects, including l -dopa-induced dyskinesia (LID). Recently, our group reported that KD5040, a modified herbal remedy, had neuroprotective effects in both in vitro and in vivo models of PD. Thus, the present study investigated whether KD5040 would have synergistic effects with l -dopa and antidyskinetic effects caused by l -dopa as well...
April 19, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28423013/mapping-the-co-localization-of-the-circadian-proteins-per2-and-bmal1-with-enkephalin-and-substance-p-throughout-the-rodent-forebrain
#4
Ariana Frederick, Jory Goldsmith, Nuria de Zavalia, Shimon Amir
Despite rhythmic expression of clock genes being found throughout the central nervous system, very little is known about their function outside of the suprachiasmatic nucleus. Determining the pattern of clock gene expression across neuronal subpopulations is a key step in understanding their regulation and how they may influence the functions of various brain structures. Using immunofluorescence and confocal microscopy, we quantified the co-expression of the clock proteins BMAL1 and PER2 with two neuropeptides, Substance P (SubP) and Enkephalin (Enk), expressed in distinct neuronal populations throughout the forebrain...
2017: PloS One
https://www.readbyqxmd.com/read/28417221/co-localization-of-zinc-transporter-3-znt3-with-sensory-neuromediators-and-or-neuromodulators-in-the-enteric-nervous-system-of-the-porcine-esophagus
#5
Joanna Wojtkiewicz, Liliana Rytel, Krystyna Makowska, Sławomir Gonkowski
Zinc transporter 3 (ZnT3) is one of the zinc transporters family. It is closely connected to the nervous system, where enables the transport of zinc ions from the cytoplasm to synaptic vesicles. This substance has been described within the central and peripheral nervous system, especially in the enteric nervous system (ENS). The aim of the present study was to describe the co-localization of ZnT3 with selected neuromediators and/or neuromodulators participating in sensory stimuli conduction in neurons of the ENS within the porcine esophagus...
April 17, 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28404689/methoxyluteolin-inhibits-neuropeptide-stimulated-tnf-cxcl8-and-vegf-release-via-mtor-activation-from-human-mast-cells
#6
Arti B Patel, Theoharis C Theoharides
Mast cells (MC) are critical for allergic reactions, but are also important in inflammatory processes. Stimulation by neuropeptides, such as substance P (SP) and neurotensin (NT) leads to release of pre-formed molecules stored in numerous MC secretory granules and newly-synthesized pro-inflammatory mediators, including tumor necrosis factor (TNF), interleukin 8 (CXCL8) and vascular endothelial growth factor (VEGF). Here, we investigate the role of mammalian target of rapamycin (mTOR) signaling in the stimulation of cultured human LAD2 MC by NT or SP, and the inhibitory effect of the natural flavonoids 3',4',5,7-tetrahydroxyflavone (luteolin) and its novel structural analog 3 ',4',5,7-tetramethoxyluteolin (methoxyluteolin)...
April 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28404518/nanoparticle-fullerol-alleviates-radiculopathy-via-nlrp3-inflammasome-and-neuropeptides
#7
Li Jin, Mengmeng Ding, Azra Oklopcic, Bayan Aghdasi, Li Xiao, Ziyi Li, Vesna Jevtovic-Todorovic, Xudong Li
The present study aimed to evaluate the analgesic effect of the antioxidant nanoparticle fullerol in a mouse radiculopathy and a dorsal root ganglion (DRG) culture models. Intervertebral disc degeneration causes significant hyperalgesia and nerve inflammation. Pain sensitization and inflammatory reaction were counteracted by fullerol when disc material was bathed in 10 or 100μM of fullerol prior to implantation. Immunohistochemistry showed similar massive IBA1 positive macrophage infiltration surrounding implanted disc material among groups, but IL-1β and IL-6 expression was decreased in fullerol treated group...
April 9, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28399671/substance-p-increases-ccn2-dependent-on-tgf-beta-yet-collagen-type-i-via-tgf-beta1-dependent-and-independent-pathways-in-tenocytes
#8
Nagat Frara, Paul W Fisher, Yingjie Zhao, Joseph T Tarr, Mamta Amin, Steven N Popoff, Mary F Barbe
Transforming growth factor beta 1 (TGFbeta-1) and connective tissue growth factor (CCN2) are important mediators of tissue repair and fibrosis, with CCN2 functioning as a downstream mediator of TGFβ-1. Substance P (SP) is also linked to collagen production in tenocytes. A link between SP, TGFbeta-1 and CCN2 has yet to be established in tenocytes or fibrogenic processes. We sought to determine whether SP induces tenocyte proliferation, CCN2, or collagen production via TGFbeta-1 signaling or independently in rat primary tenocytes...
March 1, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28399479/changes-in-biochemical-markers-following-spinal-manipulation-a-systematic-review-and-meta-analysis
#9
REVIEW
Kesava Kovanur-Sampath, Ramakrishnan Mani, Jim Cotter, Angela Spontelli Gisselman, Steve Tumilty
The aim of this meta-analysis was to determine the effectiveness of spinal manipulation in influencing various biochemical markers in healthy and or symptomatic population. Electronic databases (n = 10) were searched (from inception till September 2016) and eight trials (325 participants) that met the inclusion criteria were included in the meta-analysis. Two authors independently extracted and assessed the risk of bias in included studies. Standardised mean differences for outcome measures were used to calculate effect sizes...
April 5, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28392402/does-seasonal-allergic-rhinitis-increase-sensitivity-to-ammonia-exposure
#10
Marlene Pacharra, Stefan Kleinbeck, Michael Schäper, Meinolf Blaszkewicz, Klaus Golka, Christoph van Thriel
Allergic inflammation in the upper airways represents a wide-spread health issue: Little is known about whether it increases sensitivity to airborne chemicals thereby challenging established exposure limits that neglect such differences in susceptibility. To investigate the role of pre-existing allergic inflammation, 19 subjects with seasonal allergic rhinitis (SAR) and 18 control subjects with low risk of sensitization were exposed for 4h to ammonia in two concentrations (cross-over design): 2.5ppm (odor threshold) and 0-40ppm (occupational exposure limit: 20ppm TWA)...
April 2, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28392070/respiratory-network-stability-and-modulatory-response-to-substance-p-require-nalcn
#11
Szu-Ying Yeh, Wei-Hsiang Huang, Wei Wang, Christopher S Ward, Eugene S Chao, Zhenyu Wu, Bin Tang, Jianrong Tang, Jenny J Sun, Meike Esther van der Heijden, Paul A Gray, Mingshan Xue, Russell S Ray, Dejian Ren, Huda Y Zoghbi
Respiration is a rhythmic activity as well as one that requires responsiveness to internal and external circumstances; both the rhythm and neuromodulatory responses of breathing are controlled by brainstem neurons in the preBötzinger complex (preBötC) and the retrotrapezoid nucleus (RTN), but the specific ion channels essential to these activities remain to be identified. Because deficiency of sodium leak channel, non-selective (Nalcn) causes lethal apnea in humans and mice, we investigated Nalcn function in these neuronal groups...
April 19, 2017: Neuron
https://www.readbyqxmd.com/read/28390968/inhibition-of-substance-p-induced-defensive-behavior-via-neurokinin-1-receptor-antagonism-in-the-central-and-medial-but-not-basolateral-nuclei-of-the-amygdala-in-male-wistar-rats
#12
G S Bassi, M C Carvalho, R C Almada, M L Brandão
RATIONALE: The production of unconditioned defensive behaviors has been related to the amygdala, a key component of the encephalic aversion system. Microinjection of the neuropeptide substance P (SP) in the amygdala elicits defensive behaviors via the activation of type 1 neurokinin (NK-1) receptors. However, no studies have investigated whether intra-amygdala SP/NK-1 mechanisms can elicit other types of defensive responses, such as antinociception and ultrasonic vocalizations (USVs)...
April 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28386018/panin-neuroendocrine-cells-promote-tumorigenesis-via-neuronal-cross-talk
#13
Smrita Sinha, Ya-Yuan Fu, Adrien Grimont, Maren Ketcham, Kelly Lafaro, Joseph A Saglimbeni, Gokce Askan, Jennifer M Bailey, Jerry P Melchor, Yi Zhong, Min Geol Joo, Olivera Grbovic-Huezo, In-Hong Yang, Olca Basturk, Lindsey Baker, Young Park, Robert C Kurtz, David Tuveson, Steven D Leach, Pankaj J Pasricha
Nerves are a notable feature of the tumor microenvironment in some epithelial tumors, but their role in the malignant progression of pancreatic ductal adenocarcinoma (PDAC) is uncertain. Here, we identify dense innervation in the microenvironment of precancerous pancreatic lesions, known as pancreatic intraepithelial neoplasms (PanIN), and describe a unique subpopulation of neuroendocrine PanIN cells that express the neuropeptide substance P (SP) receptor neurokinin 1-R (NK1-R). Using organoid culture, we demonstrated that sensory neurons promoted the proliferation of PanIN organoids via SP-NK1-R signaling and STAT3 activation...
April 6, 2017: Cancer Research
https://www.readbyqxmd.com/read/28381725/pursuit-of-neurotransmitter-functions-being-attracted-with-fascination-of-the-synapse
#14
Shiro Konishi
 In the beginning of the 1970s, only two chemical substances, acetylcholine and γ-aminobutyric acid (GABA), had been definitely established as neurotransmitters. Under such circumstances, I started my scientific career in Professor Masanori Otsuka's lab searching for the transmitter of primary sensory neurons. Until 1976, lines of evidence had accumulated indicating that the undecapeptide substance P could be released as a transmitter from primary afferent fibers into spinal synapses, although the substance P-mediated synaptic response had yet to be identified...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28380612/effect-of-rest-stop-duration-during-long-distance-transport-on-welfare-indicators-in-recently-weaned-beef-calves
#15
S Marti, R E Wilde, D Moya, C E M Heuston, F Brown, K S Schwartzkopf-Genswein
Forty newly weaned beef calves (260 ± 32.6 kg) were transported 15 h in a livestock trailer (7.3 by 2.1 m) on 2 separate hauls 1 wk apart (20 calves/haul) to evaluate the effect of rest stop duration on indicators of calf welfare. Immediately following the 15-h journey, 15 calves/haul were randomly unloaded at a feedlot and randomly assigned to 1 of 3 rest stop treatments; calves without resting time (5 calves/haul) remained on the trailer and were used as the control group. Treatments included 0- (Control [CON]), 5- (RS5), 10- (RS10), or 15-h (RS15) rest periods in pens containing ad libitum access to water and long-stem hay...
February 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28369749/olcegepant-blocks-neurogenic-and-non-neurogenic-cgrpergic-vasodepressor-responses-and-facilitates-noradrenergic-vasopressor-responses-in-pithed-rats
#16
V H Avilés-Rosas, E Rivera-Mancilla, B A Marichal-Cancino, G Manrique-Maldonado, A H Altamirano-Espinoza, A MaassenVanDenBrink, C M Villalón
BACKGROUND AND PURPOSE: Olcegepant (BIBN4096BS) is a selective non-peptide CGRP receptor antagonist with acute antimigraine properties. Since systemic vascular tone is modulated by perivascular (primary sensory CGRPergic and sympathetic) nerves, this randomized study investigated in pithed rats the effect of acute intravenous (i.v.) treatment with olcegepant on the neurogenic and non-neurogenic: (i) CGRPergic vasodepressor responses; and (ii) noradrenergic vasopressor responses. The pithed rat is an experimental model predictive of systemic (cardio) vascular side effects...
March 29, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28366881/substance-p-mediated-chemokine-production-promotes-monocyte-migration
#17
Sergei Spitsin, John Meshki, Angela Winters, Florin Tuluc, Tami D Benton, Steven D Douglas
The neuropeptide SP has physiologic and pathophysiologic roles in CNS and peripheral tissues and is involved in crosstalk between nervous and immune systems in various conditions, including HIV and SIV infection. Increased SP levels were demonstrated in plasma of HIV(+) individuals as well as in the CNS of SIV-infected, nonhuman primates. SP increases HIV infection in macrophages through interaction with its receptor, NK1R. The SP effect on immune system is both pro- and anti-inflammatory and includes up-regulation of a number of cytokines and cell receptors...
April 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28366675/the-dual-regulation-of-substance-p-mediated-inflammation-via-human-synovial-mast-cells-in-rheumatoid-arthritis
#18
Yuki Okamura, Shintaro Mishima, Jun-Ichi Kashiwakura, Tomomi Sasaki-Sakamoto, Shota Toyoshima, Kazumichi Kuroda, Shu Saito, Yasuaki Tokuhashi, Yoshimichi Okayama
BACKGROUND: Neural pathways are thought to be directly involved in the pathogenesis of rheumatoid arthritis (RA). Although synovial mast cells (MCs) are activated by substance P (SP), the role of MCs in neural pathways in RA remains unknown. The aims of this study were to investigate 1) whether tachykinins are produced by synovial MCs and whether production differs in RA and osteoarthritis (OA) patients, and 2) what is the responsible receptor for SP in synovial MCs. METHODS: Synovial tissues were obtained from patients with RA or OA undergoing joint replacement surgery...
March 30, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28365081/a-possible-role-for-cd26-dppiv-enzyme-activity-in-the-regulation-of-psoriatic-pruritus
#19
Eriko Komiya, Ryo Hatano, Haruna Otsuka, Takumi Itoh, Hiroto Yamazaki, Taketo Yamada, Nam H Dang, Mitsutoshi Tominaga, Yasushi Suga, Utako Kimura, Kenji Takamori, Chikao Morimoto, Kei Ohnuma
BACKGROUND: Psoriasis (PSO) is one of the most common chronic inflammatory skin diseases, and pruritus affects approximately 60-90% of patients with PSO. However, the pathogenesis of pruritus in PSO remains unclear. Dipeptidyl peptidase IV (DPPIV) enzyme activity is involved in the regulation of peptide hormones, chemokines and neurotransmitters. OBJECTIVES: Our aim is to evaluate for a potential association between DPPIV and an increased risk of pruritus, and to identify possible underlying treatment targets in affected patients...
March 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28364109/-role-of-substance-p-and-calcitonin-gene-related-peptide-in-bone-metabolism
#20
Shuanglei Wang, Jie Xiao, Zhanchun Li
Substance P (SP) and calcitonin gene-related peptide (CGRP) are the neuropeptides released from the sensory nerve endings. Neuropeptides play a role in bone and the relevant organs. It exerts functions in regulation of the bone metabolism, fracture healing and pain by a certain way. The biological properties and distributions of SP and CGRP are closely related to the pathogenesis and development of bone metabolism, fracture healing and pain.
March 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
keyword
keyword
62994
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"