Dong Yang, Yanfang Zhang, Ibrahima Sory Sow, Hongping Liang, Naïma El Manssouri, Michel Gelbcke, Lina Dong, Guangxin Chen, François Dufrasne, Véronique Fontaine, Rongshan Li
Hydroxamic acid (HA) derivatives display antibacterial and antifungal activities. HA with various numbers of carbon atoms (C2 , C6 , C8 , C10 , C12 and C17 ), complexed with different metal ions, including Fe(II/III), Ni(II), Cu(II) and Zn(II), were evaluated for their antimycobacterial activities and their anti-biofilm activities. Some derivatives showed antimycobacterial activities, especially in biofilm growth conditions. For example, 20-100 µM of HA10Fe2, HA10FeCl, HA10Fe3, HA10Ni2 or HA10Cu2 inhibited Mycobacterium tuberculosis , Mycobacterium bovis BCG and Mycobacterium marinum biofilm development...
October 23, 2023: Microorganisms