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Myofibrillar

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https://www.readbyqxmd.com/read/29599744/myopathy-with-sqstm1-and-tia1-variants-clinical-and-pathological-features
#1
Zhiyv Niu, Carly Sabine Pontifex, Sarah Berini, Leslie E Hamilton, Elie Naddaf, Eric Wieben, Ross A Aleff, Kristina Martens, Angela Gruber, Andrew G Engel, Gerald Pfeffer, Margherita Milone
Objective: The aim of this study is to identify the molecular defect of three unrelated individuals with late-onset predominant distal myopathy; to describe the spectrum of phenotype resulting from the contributing role of two variants in genes located on two different chromosomes; and to highlight the underappreciated complex forms of genetic myopathies. Patients and methods: Clinical and laboratory data of three unrelated probands with predominantly distal weakness manifesting in the sixth-seventh decade of life, and available affected and unaffected family members were reviewed...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29579896/molecular-interactions-and-redox-effects-of-carvacrol-and-thymol-on-myofibrillar-proteins-using-a-non-destructive-and-solvent-free-methodological-approach
#2
Aida Lahmar, Tolga Akcan, Leila Chekir-Ghedira, Mario Estévez
The present study provides molecular insight into the effect of thymol and carvacrol on the oxidative damage caused to myofibrillar proteins by a hydroxyl-radical generating system (HRGS). An innovative model system was designed, in which gels, prepared with increasing levels of myofibrillar proteins, were oxidized by a HRGS (Fe3+ /H2 O2 , 60 °C and 7 days) in the presence of lipids. The molecular affinity between myofibrillar proteins and both terpenes, as well as their effect on the oxidative stability of the gel systems, were studied using a non-destructive and solvent-free procedure based on fluorescence spectroscopy...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29561661/hsp90-modulates-the-myosin-replacement-rate-in-myofibrils
#3
Koichi Ojima, Emi Ichimura, Takahiro Suzuki, Mika Oe, Susumu Muroya, Takanori Nishimura
Myosin is a major myofibrillar component in skeletal muscles. In myofibrils, approximately 300 myosin molecules form a single thick filament in which there is constant turnover of myosin. Our previous study demonstrated that the myosin replacement rate is reduced by inhibition of protein synthesis (Ojima K. et al. 2015 Am. J. Physiol. Cell Physiol. 309, C669-679); however, additional factors influencing myosin replacement were unknown. Here, we showed that rapid myosin replacement requires heat shock protein 90 (HSP90) activity...
March 21, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29557519/protein-availability-and-satellite-cell-dynamics-in-skeletal-muscle
#4
REVIEW
Baubak Shamim, John A Hawley, Donny M Camera
Human skeletal muscle satellite cells are activated in response to both resistance and endurance exercise. It was initially proposed that satellite cell proliferation and differentiation were only required to support resistance exercise-induced hypertrophy. However, satellite cells may also play a role in muscle fibre remodelling after endurance-based exercise and extracellular matrix regulation. Given the importance of dietary protein, particularly branched chain amino acids, in supporting myofibrillar and mitochondrial adaptations to both resistance and endurance-based training, a greater understanding of how protein intake impacts satellite cell activity would provide further insight into the mechanisms governing skeletal muscle remodelling with exercise...
March 20, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29548472/effects-of-electron-beam-irradiation-on-the-biochemical-properties-and-structure-of-myofibrillar-protein-from-tegillarca-granosa-meat
#5
Mingchun Lv, Kalin Mei, Han Zhang, Dalun Xu, Wenge Yang
The effect of electron beam irradiation at doses of 0-9 kGy on the biochemical properties and structure of myofibrillar protein from Tegillarca granosa (T. granosa) was investigated. There was no effect of irradiation on the surface hydrophobicity of the myofibrillar protein, however total sulfhydryl content and Ca2+ -ATPase activity both declined to varying extents with increasing irradiation dose. Irradiation also affected the composition of the myofibrillar protein; with increasing dose of irradiation, the actin, paramyosin and myosin heavy chain contents of the myofibrillar protein were partially degraded...
July 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29548456/effects-of-macro-nutrient-micro-nutrient-composition-and-cooking-conditions-on-in-vitro-digestibility-of-meat-and-aquatic-dietary-proteins
#6
Jiaqiang Luo, Cheryl Taylor, Thomas Nebl, Ken Ng, Louise E Bennett
Animal and aquatic meats represent important sources of dietary protein and micro-nutrients. Although red and processed meats carry some risks for human health, sensory and nutritional advantages drive meat consumption. Therefore, it is important to understand how meat processing and cooking influence healthiness. The research aim was to investigate relationships of meat composition (proximates, amino acids and minerals) and cooking conditions (raw, 90 s microwave, 200 °C oven for 10 or 30 min) on protein digestibility, for a selection of four animal (beef, chicken, pork, kangaroo) and four aquatic meats (salmon, trout, prawn, oyster)...
July 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29532476/effect-of-resistance-training-and-protein-intake-pattern-on-myofibrillar-protein-synthesis-and-proteome-kinetics-in-older-men-in-energy-restriction
#7
Caoileann H Murphy, Mahalakshmi Shankaran, Tyler A Churchward-Venne, Cameron J Mitchell, Nathan M Kolar, Louise M Burke, John A Hawley, Amira Kassis, Leonidas G Karagounis, Kelvin Li, Chelsea King, Marc Hellerstein, Stuart M Phillips
We determined how the pattern of protein intake and resistance training (RT) influenced longer-term (2-wk) integrated myofibrillar protein synthesis (MyoPS) during energy restriction (ER). MyoPS and proteome kinetics were measured during 2-wk of ER alone and 2-wk of ER plus RT (ER + RT) in overweight/obese older men. Participants were randomized to consume dietary protein in a balanced (BAL: 25% daily protein/meal x 4 meals) or skewed (SKEW: 7:17:72:4% daily protein/meal) pattern (n = 10/group). Participants ingested D2 O during the consecutive 2-wk periods, and skeletal muscle biopsies and serum were obtained at the beginning and conclusion of ER and ER + RT...
March 12, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29529146/protein-leucine-content-is-a-determinant-of-shorter-and-longer-term-muscle-protein-synthetic-responses-at-rest-and-following-resistance-exercise-in-healthy-older-women-a-randomized-controlled-trial
#8
Michaela C Devries, Christopher McGlory, Douglas R Bolster, Alison Kamil, Maike Rahn, Laura Harkness, Steven K Baker, Stuart M Phillips
Background: Older women may not be consuming enough protein to maintain muscle mass. Augmentation of protein intake with leucine may enhance the muscle protein synthetic response in older women to aid in maintaining muscle mass. Objective: We measured the acute (hourly) and integrated (daily) myofibrillar protein synthesis (myoPS) response to consumption of a high-quality mixed protein beverage compared with an isonitrogenous protein beverage with added leucine...
February 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29528394/calpain-3-and-camkii%C3%AE-signaling-are-required-to-induce-hsp70-necessary-for-adaptive-muscle-growth-after-atrophy
#9
Irina Kramerova, Jorge A Torres, Ascia Eskin, Stanley F Nelson, Melissa J Spencer
Mutations in CAPN3 cause autosomal recessive limb girdle muscular dystrophy 2A. Calpain 3 (CAPN3) is a calcium dependent protease residing in the myofibrillar, cytosolic and triad fractions of skeletal muscle. At the triad, it colocalizes with calcium calmodulin kinase IIβ (CaMKIIβ). CAPN3 knock out mice (C3KO) show reduced triad integrity and blunted CaMKIIβ signaling, which correlates with impaired transcriptional activation of myofibrillar and oxidative metabolism genes in response to running exercise...
March 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29522375/fropofol-decreases-force-development-in-cardiac-muscle
#10
Xianfeng Ren, William Schmidt, Yiyuan Huang, Haisong Lu, Wenjie Liu, Weiming Bu, Roderic Eckenhoff, Anthony Cammarato, Wei Dong Gao
Supranormal contractile properties are frequently associated with cardiac diseases. Anesthetic agents, including propofol, can depress myocardial contraction. We tested the hypothesis that fropofol, a propofol derivative, reduces force development in cardiac muscles via inhibition of cross-bridge cycling and may therefore have therapeutic potential. Force and intracellular Ca2+ ([Ca2+ ]i ) transients of rat trabecular muscles were determined. Myofilament ATPase, actin-activated myosin ATPase, and velocity of actin filaments propelled by myosin were also measured...
March 9, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29520298/association-of-%C3%AE-calpain-and-calpastatin-polymorphisms-with-meat-tenderness-in-a-brahman-angus-population
#11
Joel D Leal-Gutiérrez, Mauricio A Elzo, Dwain D Johnson, Tracy L Scheffler, Jason M Scheffler, Raluca G Mateescu
Autogenous proteolytic enzymes of the calpain family are implicated in myofibrillar protein degradation. As a result, the μ-calpain gene and its specific inhibitor, calpastatin, have been repeatedly investigated for their association with meat quality traits in cattle; however, no functional mutation has been identified for these two genes. The objectives of this study were: (1) to assess breed composition effect on tenderness; (2) to perform a linkage disequilibrium (LD) analysis in μ-calpain and calpastatin genes as well as an association analyses with tenderness; and (3) to analyze putative functional SNPs inside the significant LD block for an effect on tenderness...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29515442/ginkgolide-c-alleviates-myocardial-ischemia-reperfusion-induced-inflammatory-injury-via-inhibition-of-cd40-nf-%C3%AE%C2%BAb-pathway
#12
Rui Zhang, Dan Han, Zhenyu Li, Chengwu Shen, Yahui Zhang, Jun Li, Genquan Yan, Shasha Li, Bo Hu, Jiangbing Li, Ping Liu
Increasing evidence shows that inflammation plays a vital role in the occurrence and development of ischemia/reperfusion (I/R). Suppression of excessive inflammation can ameliorate impaired cardiac function, which shows therapeutic potential for clinical treatment of myocardial ischemia/reperfusion (MI/R) diseases. In this study, we investigated whether Ginkgolide C (GC), a potent anti-inflammatory flavone, extenuated MI/R injury through inhibition of inflammation. In vivo , rats with the occlusion of the left anterior descending (LAD) coronary artery were applied to mimic MI/R injury...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29514422/physico-chemical-and-thermal-properties-of-chicken-myofibrillar-protein-concentrate-cmpc-mixed-with-barley-bran-flour-during-frozen-storage
#13
Krešimir Mastanjević, Dragan Kovačević
BACKGROUND: Possible new additives for surimi-like products made from chicken meat, which could improve its functional properties during frozen storage, are the subject of much research. The use of dietary fibre in surimi-like products made from chicken meat has not been extensively studied. The objective of this study was to determine the effectiveness of barley bran flour in stabilizing chicken myofibrillar proteins during frozen storage and maintaining its functionality. METHODS: Surimi-like material (chicken myofibrillar protein concentrate – CMPC) from mechanically deboned chicken meat was mixed with barley bran flour (0–6%) and stored in a freezer for 30, 60, 90 and 180 days...
January 2018: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/29512299/translocation-and-protein-complex-co-localization-of-mtor-is-associated-with-postprandial-myofibrillar-protein-synthesis-at-rest-and-after-endurance-exercise
#14
Sidney Abou Sawan, Stephan van Vliet, Justin T Parel, Joseph W Beals, Michael Mazzulla, Daniel W D West, Andrew Philp, Zhong Li, Scott A Paluska, Nicholas A Burd, Daniel R Moore
Translocation and colocalization of mechanistic target of rapamycin complex 1 (mTORC1) with regulatory proteins represents a critical step in translation initiation of protein synthesis in vitro. However, mechanistic insight into the control of postprandial skeletal muscle protein synthesis rates at rest and after an acute bout of endurance exercise in humans is lacking. In crossover trials, eight endurance-trained men received primed-continuous infusions of L-[ring-2 H5 ]phenylalanine and consumed a mixed-macronutrient meal (18 g protein, 60 g carbohydrates, 17 g fat) at rest (REST) and after 60 min of treadmill running at 70% VO2peak (EX)...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29508695/%C3%AE-hydroxy-%C3%AE-methylbutyrate-free-acid-alters-cortisol-responses-but-not-myofibrillar-proteolysis-during-a-24-h-fast
#15
Grant M Tinsley, Amy H Givan, Austin J Graybeal, Michael I Villarreal, Austin G Cross
This study was a randomised, double-blind, placebo-controlled cross-over trial examining the effects of β-hydroxy β-methylbutyrate free acid (HMB-FA) supplementation on muscle protein breakdown, cortisol, testosterone and resting energy expenditure (REE) during acute fasting. Conditions consisted of supplementation with 3 g/d HMB-FA or placebo during a 3-d meat-free diet followed by a 24-h fast. Urine was collected before and during the 24-h fast for analysis of 3-methylhistidine:creatinine ratio (3MH:CR)...
March 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29478520/emulsifying-properties-development-of-pork-myofibrillar-and-sacroplasmic-protein-irradiated-at-different-dose-a-combined-ft-ir-spectroscopy-and-low-field-nmr-study
#16
Chengliang Li, An Peng, Lichao He, Sumin Ma, Wenmin Wu, Haiyan Yang, Xiuxiu Sun, Qi Zeng, Guofeng Jin, Jianhao Zhang, Meihu Ma
The present study investigated the effect of different irradiation dose (0, 3, 5 and 7 kGy) on the emulsifying properties development of pork myofibrillar protein (MP) and sacroplasmic protein (SP). The results showed that emulsifying activities of SP was significantly impaired by the increasing irradiation dose, while that of MP were only observed to be significantly improved at 3 kGy irradiation (P < .05). The increasing irradiation dose caused the increase of SP carbonyl groups and the decrease of its sulfhydryl groups (P < ...
June 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29470691/even-effect-of-milk-protein-and-carbohydrate-intake-but-no-further-effect-of-heavy-resistance-exercise-on-myofibrillar-protein-synthesis-in-older-men
#17
Søren Reitelseder, Kasper Dideriksen, Jakob Agergaard, Nikolaj M Malmgaard-Clausen, Rasmus L Bechshoeft, Rasmus K Petersen, Anja Serena, Ulla R Mikkelsen, Lars Holm
PURPOSE: The responsiveness of older individuals' skeletal muscle to anabolic strategies may be impaired. However, direct comparisons within the same experimental setting are sparse. The aim of this study was to assess the resting and post-resistance exercise muscle protein synthesis rates in response to two types of milk protein and carbohydrate using a unilateral exercise leg model. METHODS: Twenty-seven older (69 ± 1 year, mean ± SE) men were randomly assigned one of three groups: Whey hydrolysate (WH), caseinate (CAS), or carbohydrate (CHO)...
February 22, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29459321/bioengineering-an-electro-mechanically-functional-miniature-ventricular-heart-chamber-from-human-pluripotent-stem-cells
#18
Ronald A Li, Wendy Keung, Timothy J Cashman, Peter C Backeris, Bryce V Johnson, Evan S Bardot, Andy O T Wong, Patrick K W Chan, Camie W Y Chan, Kevin D Costa
Tissue engineers and stem cell biologists have made exciting progress toward creating simplified models of human heart muscles or aligned monolayers to help bridge a longstanding gap between experimental animals and clinical trials. However, no existing human in vitro systems provide the direct measures of cardiac performance as a pump. Here, we developed a next-generation in vitro biomimetic model of pumping human heart chamber, and demonstrated its capability for pharmaceutical testing. From human pluripotent stem cell (hPSC)-derived ventricular cardiomyocytes (hvCM) embedded in collagen-based extracellular matrix hydrogel, we engineered a three-dimensional (3D) electro-mechanically coupled, fluid-ejecting miniature human ventricle-like cardiac organoid chamber (hvCOC)...
May 2018: Biomaterials
https://www.readbyqxmd.com/read/29457652/expanding-the-histopathological-spectrum-of-cfl2-related-myopathies
#19
F Fattori, C Fiorillo, C Rodolico, G Tasca, M Verardo, E Bellacchio, S Pizzi, A Ciolfi, G Fagiolari, A Lupica, P Broda, M Pedemonte, M Moggio, C Bruno, M Tartaglia, E Bertini, A D'Amico
Congenital myopathies (CMs) caused by mutation in cofilin-2 gene (CFL2) show phenotypic heterogeneity ranging from early onset and rapid progressive forms to milder myopathy. Muscle histology is also heterogeneous showing rods and /or myofibrillar changes. Here, we report on three new cases, from two unrelated families, of severe CM related to novel homozygous or compound heterozygous loss-of-function mutations in CFL2. Peculiar histopathological changes showed nemaline bodies and thin filaments accumulations together to myofibrillar changes, which were evocative of the muscle findings observed in Cfl2-/- knockout mouse model...
February 19, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29454057/pullulan-suppresses-the-denaturation-of-myofibrillar-protein-of-grass-carp-ctenopharyngodon-idella-during-frozen-storage
#20
Longfa Jiang, Shengjun Wu
This study aims to investigate the effect of pullulan on the denaturation of the myofibrillar protein of grass carp (Ctenopharyngodon idella) during frozen storage at -18 °C for 30 days. Pullulan or commercial cryoprotectant (1 g dry weight) were added to 100 g of the myofibrillar protein of grass carp (C. idella), respectively, which was frozenly stored at -18 °C for 30 days, and the changes in the state of unfrozen of water, solubility, Ca 2+ -adenylpyrophosphatase (ATP ase ) activity, and sulfhydryl content of myofibrils were monitored during frozen storage...
February 14, 2018: International Journal of Biological Macromolecules
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