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https://www.readbyqxmd.com/read/29332825/development-of-gd3-immobilized-glutathione-coated-magnetic-nanoparticles-for-highly-selective-enrichment-of-phosphopeptides
#1
Dandan Jiang, Xiqian Li, Jiutong Ma, Qiong Jia
In this study, we designed a gadolinium-based immobilized metal ion affinity chromatography material for the selective enrichment of phosphopeptides. Gadolinium ion was immobilized on the surface of glutathione-coated magnetic nanoparticles through a facile and effective synthetic route. The adsorbent integrated the advantages of superparamagnetism of Fe3O4 core, good biological compatibility of glutathione, and strong interaction between gadolinium ion and phosphopeptides. It was employed to enrich phosphopeptides from standard protein digests coupled with MALDI-TOF MS...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29330461/comparing-olive-oil-and-c4-dietary-oil-a-prodrug-for-the-gpr119-agonist-2-oleoyl-glycerol-less-energy-intake-of-the-latter-is-needed-to-stimulate-incretin-hormone-secretion-in-overweight-subjects-with-type-2-diabetes
#2
Mette Johannsen Mandøe, Katrine Bagge Hansen, Johanne Agerlin Windeløv, Filip Krag Knop, Jens Frederik Rehfeld, Mette Marie Rosenkilde, Jens Juul Holst, Harald Severin Hansen
BACKGROUND/OBJECTIVE: After digestion, dietary triacylglycerol stimulates incretin release in humans, mainly through generation of 2-monoacylglycerol, an agonist for the intestinal G protein-coupled receptor 119 (GPR119). Enhanced incretin release may have beneficial metabolic effects. However, dietary fat may promote weight gain and should therefore be restricted in obesity. We designed C4-dietary oil (1,3-di-butyryl-2-oleoyl glycerol) as a 2-oleoyl glycerol (2-OG)-generating fat type, which would stimulate incretin release to the same extent while providing less calories than equimolar amounts of common triglycerides, e...
January 12, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29327229/leopoldia-comosa-prevents-metabolic-disorders-in-rats-with-high-fat-diet-induced-obesity
#3
T Casacchia, F Scavello, C Rocca, M C Granieri, G Beretta, D Amelio, F Gelmini, A Spena, R Mazza, C C Toma, Tommaso Angelone, Giancarlo Statti, T Pasqua
PURPOSE: Obesity is the main feature of a complex illness known as metabolic syndrome. Anti-obesogenic therapies are often associated with side effects and represent a high cost in conventional pharmacological approaches. New strategies based on natural remedies are under continuous investigation. Leopoldia comosa (L.) Parl. (L. comosa) is a spontaneous plant with diuretic, anti-inflammatory and antioxidant properties. Recently, a hypoglycemic activity mediated by inhibition of carbohydrate digestion has been identified...
January 11, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29325602/bile-acid-metabolism-in-liver-pathobiology
#4
John Y L Chiang, Jessica M Ferrell
Bile acids facilitate intestinal nutrient absorption and biliary cholesterol secretion to maintain bile acid homeostasis, which is essential for protecting liver and other tissues and cells from cholesterol and bile acid toxicity. Bile acid metabolism is tightly regulated by bile acid synthesis in the liver and bile acid biotransformation in the intestine. Bile acids are endogenous ligands that activate a complex network of nuclear receptor farnesoid X receptor and membrane G protein-coupled bile acid receptor-1 to regulate hepatic lipid and glucose metabolic homeostasis and energy metabolism...
January 11, 2018: Gene Expression
https://www.readbyqxmd.com/read/29322140/development-of-antioxidant-gliadin-particle-stabilized-pickering-high-internal-phase-emulsions-hipes-as-oral-delivery-systems-and-the-in-vitro-digestion-fate
#5
F Z Zhou, T Zeng, S W Yin, C H Tang, D B Yuan, X Q Yang
In this paper, we demonstrate for the first time the use of gliadin particles to structure algal oil (rich in DHA) and to exert chemical stability against lipid oxidation via the Pickering high internal phase emulsion (HIPE) strategy. The gliadin/chitosan colloid particles (GCCPs) were effectively adsorbed and anchored at the algal oil-water interface. Concomitantly, the particle-coated droplets as building blocks constructed a percolating 3D-network framework, endowing Pickering HIPEs with viscoelastic and self-supporting attributes...
January 11, 2018: Food & Function
https://www.readbyqxmd.com/read/29305859/n-oleoylethanolamide-suppresses-intimal-hyperplasia-after-balloon-injury-in-rats-through-ampk-ppar%C3%AE-pathway
#6
Yun Zhao, Yijun Liu, Zuo Jing, Lu Peng, Peng Jin, Yangbin Lin, Yu Zhou, Lichao Yang, Jie Ren, Qiang Xie, Xin Jin
Vascular smooth muscle cell (VSMC) proliferation and migration are crucial events in the pathological course of restenosis after percutaneous coronary intervention (PCI). N-oleoylethanolamide (OEA) is a bioactive lipid amide released upon dietary fat digestion with many reported actions. However, the effect of OEA on restenosis after vascular injury remains unknown. Here, we investigated the effects of OEA on intimal hyperplasia after balloon injury in vivo, its effect on VSMC proliferation and migration induced by platelet-derived growth factor (PDGF) stimulation in vitro, and the underlying mechanism underlying these effects...
January 3, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29299670/flexibility-is-the-key-metabolic-and-thermoregulatory-behaviour-in-a-small-endotherm
#7
Franz Langer, Nadine Havenstein, Joanna Fietz
Hibernation is the most effective way to reduce thermoregulatory costs during periods of unfavourable environmental conditions. In preparation to hibernation, fat-storing hibernators accumulate large quantities of body fat, which increases their locomotor costs and also the risk of predation. As a consequence, there should be a strong selective pressure to restrict pre-hibernation fattening to a short-time period before the onset of hibernation. The edible dormouse (Glis glis) is characterized by having adapted its whole life history to the irregularly occurring mast-seeding pattern of the European beech (Fagus sylvaticus)...
January 3, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29297503/cholecystectomy-a-way-forward-and-back-to-metabolic-syndrome
#8
EDITORIAL
Gabriella Garruti, David Q-H Wang, Agostino Di Ciaula, Piero Portincasa
The gallbladder provides rhythmic secretion of concentrated bile acids (BAs) during fasting and postprandially contributes to digestion of dietary lipids. In addition, BAs activate metabolic pathways governing gluco-lipid homeostasis and energy expenditure via the farnesoid X nuclear receptor (FXR), G protein-coupled BA receptor 1 (GPBAR-1), and fibroblast growth factor 19 (FGF19) in the liver, intestine, brown fat, and muscle. Cholecystectomy is standard treatment worldwide for symptomatic gallstone patients...
January 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29297107/dairy-cows-fed-on-tropical-legume-forages-effects-on-milk-yield-nutrients-use-efficiency-and-profitability
#9
J M Castro-Montoya, R A García, R A Ramos, J M Flores, E A Alas, E E Corea
Two trials with multiparous dairy cows were conducted. Experiment 1 tested the effects of increasing forage proportion in the diet (500, 600, and 700 g/kg DM) when a mixed sorghum (Sorghum bicolor) and jackbean (Cannavalia ensiformis) silage was used as forage. Experiment 2 studied the substitution of sorghum silage and soybean meal by jackbean silage or fresh cowpea (Vigna unguiculata) forage in the diet. All diets were iso-energetic and iso-proteic. In each experiment, 30 cows were used and separated into three groups...
January 2, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29290449/lactation-response-to-soybean-meal-and-rumen-protected-methionine-supplementation-of-corn-silage-based-diets
#10
H Nursoy, M Gonzalez Ronquillo, A P Faciola, G A Broderick
Corn silage, an important forage fed to dairy cows in the United States, is energy rich but protein poor. The objectives of this experiment were to investigate the effects on production of milk and milk components of feeding corn silage-based diets with 4 levels of dietary crude protein (CP) plus rumen-protected methionine (RPM). Thirty-six cows were blocked by days in milk into 9 squares and randomly assigned to 9 balanced 4 × 4 Latin squares with four 4-wk periods. All diets were formulated to contain, as a percent of dry matter (DM), 50% corn silage, 10% alfalfa silage, 4% soyhulls, 2...
December 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29287434/yak-milk-fat-globules-from-the-qinghai-tibetan-plateau-membrane-lipid-composition-and-morphological-properties
#11
Jie Luo, Ziyu Huang, Hongna Liu, Yan Zhang, Fazheng Ren
Yak milk fat products constitute the base of Qinghai-Tibetan pastoralists' daily food intake. Despite the great importance of fat in processing and pastoralists' health, studies about yak milk fat are scarce. In this study, the lipid composition and the morphological properties of milk fat globule membranes (MFGMs) of yak milk were investigated. The results demonstrated that the yak milk had a higher cholesterol and sphingomyelin content compared to cow milk. In situ structural investigations performed at 25 °C by confocal microscopy showed the presence of lipid domains in yak MFGM, with a larger number and wider size range compared to cow milk...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29274984/production-milk-and-plasma-fatty-acid-profile-and-nutrient-utilization-in-jersey-cows-fed-flaxseed-oil-and-corn-grain-with-different-particle-size
#12
V Brossillon, S F Reis, D C Moura, J G B Galvão, A S Oliveira, C Côrtes, A F Brito
We aimed to compare the effects of ground (GC) or cracked corn (CC), with or without flaxseed oil (FSO), on milk yield, milk and plasma fatty acid (FA) profile, and nutrient digestibility in Jersey cows fed diets formulated to contain similar starch concentrations. Twelve multiparous organic-certified Jersey cows averaging (mean ± standard deviation) 455 ± 41.9 kg of body weight and 152 ± 34 d in milk and 4 primiparous organic-certified Jersey cows averaging (mean ± standard deviation) 356 ± 2.41 kg of body weight and 174 ± 30 d in milk in the beginning of the experiment were used...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29274976/replacing-ground-corn-with-incremental-amounts-of-liquid-molasses-does-not-change-milk-enterolactone-but-decreases-production-in-dairy-cows-fed-flaxseed-meal
#13
C P Ghedini, D C Moura, R A V Santana, A S Oliveira, A F Brito
We investigated the effects of replacing ground corn (GRC) with incremental amounts of liquid molasses (LM) on milk enterolactone concentration, antioxidant enzymes activity in plasma, production, milk fatty acid (FA) profile, and nutrient utilization in Jersey cows fed flaxseed meal and low-starch diets. Sixteen multiparous organically certified Jersey cows averaging (mean ± standard deviation) 101 ± 45 d in milk, 462 ± 38 kg of body weight, and 19.8 ± 3.90 kg/d of milk in the beginning of the study were randomly assigned to treatment sequences in a replicated 4 × 4 Latin square design, with 14 d for diet adaptation and 7 d for data and sample collection...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29248228/effects-of-magnesium-source-and-monensin-on-nutrient-digestibility-and-mineral-balance-in-lactating-dairy-cows
#14
A W Tebbe, D J Wyatt, W P Weiss
The interaction of monensin and 2 supplemental Mg sources (MgO and MgSO4) on total-tract digestion of minerals and organic nutrients and milk production was evaluated in lactating dairy cattle. Eighteen multiparous Holstein cows (139 ± 35 DIM) were used in a split-plot experiment with 0 or 14 mg/kg diet DM of monensin as the whole-plot treatments and Mg source as split-plot treatments. During the entire experiment (42 d), cows remained on the same monensin treatment but received a different Mg source in each period (21 d) of the Latin square...
December 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29246110/dna-and-rna-sequence-based-gwas-highlights-membrane-transport-genes-as-key-modulators-of-milk-lactose-content
#15
Thomas J Lopdell, Kathryn Tiplady, Maksim Struchalin, Thomas J J Johnson, Michael Keehan, Ric Sherlock, Christine Couldrey, Stephen R Davis, Russell G Snell, Richard J Spelman, Mathew D Littlejohn
BACKGROUND: Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk in most species. Bovine lactose is also a key component of many human food products. However, compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we present the first GWAS focussed on analysis of milk lactose traits. RESULTS: Using a discovery population of 12,000 taurine dairy cattle, we detail 27 QTL for lactose concentration and yield, and subsequently validate the effects of 26 of these loci in a distinct population of 18,000 cows...
December 15, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29238885/peanut-cake-can-replace-soybean-meal-in-supplements-for-lactating-cows-without-affecting-production
#16
Carina Anunciação Santos Dias, Adriana Regina Bagaldo, Weiler Giacomaza Cerutti, Analívia Martins Barbosa, Gleidson Giordano Pinto de Carvalho, Emellinne Ingrid Souza Costa, Leilson Rocha Bezerra, Ronaldo Lopes Oliveira
This study evaluated the total replacement of soybean meal with peanut cake in the concentrate supplement of lactating cows grazing. Eight crossbred 5/8 Holstein × 3/8 Zebu cows between the 45th and 60th day of lactation and 507 ± 35 kg BW were distributed in a 4 × 4 double Latin square design with four levels of peanut cake (0, 110, 220, and 330 g/kg of the dry matter-DM) as a replacement of soybean meal in the concentrate supplement. The intake of pasture, total (pasture + concentrate), crude protein (CP), neutral detergent fiber (NDF), total digestible nutrients, and digestibility of the DM, CP, ether extract (EE), and NDF was not affected by the replacement of soybean meal with peanut cake...
December 13, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29236846/neutral-detergent-fibre-in-piglet-diets-digestibility-performance-and-deposition-of-body-nutrients
#17
Rafael C Nepomuceno, Pedro H Watanabe, Ednardo R Freitas, Luiz E DE Carvalho, Emanuela L DE Oliveira, Thalles R Gomes, Germana C Aguiar, Rayssa S Candido, Jordânia L Ferreira, Alini M Veira
A total 120 piglets with an average live weight of 7.00 kg, weaned at 21 days, were used to evaluate the effect of neutral detergent fibre levels on the digestibility of nutrients and energy from the diets, productive performance, and the composition and rate of deposition of nutrients and energy in the bodies of piglets in the nursery phase. The animals were distributed according to a randomized-block design into five treatments, which consisted of neutral detergent fibre levels, with six replicates and four animals per plot...
December 7, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29233589/factors-contributing-to-the-selection-of-dietary-protein-food-sources
#18
Robert R Wolfe, Jamie I Baum, Carlene Starck, Paul J Moughan
Protein is the only dietary macronutrient required for life. As such, it is reasonable to consider dietary protein as the centerpiece of a healthy eating pattern. To do so requires consideration of what type of protein should be eaten. Account should be taken of the quality of the protein, the density of the protein in the protein food source, and the non-protein components of protein food source. The quality of protein can be quantified based on the amount and profile of essential amino acids (EAAs), as well as the true ileal digestibility of the EAAs in the protein...
December 6, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29230947/dietary-slowly-digestible-starch-triggers-the-gut-brain-axis-in-obese-rats-with-accompanied-reduced-food-intake
#19
Like Y Hasek, Robert J Phillips, Genyi Zhang, Kimberly P Kinzig, Choon Young Kim, Terry L Powley, Bruce R Hamaker
SCOPE: Slowly digestible starch (SDS), as a functional carbohydrate providing a slow and sustained glucose release, may be able to modulate food intake through activation of the gut-brain axis. METHODS AND RESULTS: Diet-induced obese rats were used to test the effect on feeding behavior of high fat (HF) diets containing a SDS, fabricated to digest into the ileum, as compared to rapidly digestible starch (RDS). Ingestion of the HF-SDS diet over an 11-week period reduced daily food intake, through smaller meal size, to the same level as a lean body control group, while the group consuming the HF-RDS diet remained at a high food intake...
December 11, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29230830/in-vitro-bioaccessibility-of-individual-carotenoids-from-persimmon-diospyros-kaki-cv-rojo-brillante-used-as-an-ingredient-in-a-model-dairy-food
#20
Tomás García-Cayuela, Beatriz Nuño Escobar, Jorge Welti-Chanes, M Pilar Cano
BACKGROUND: Addition of persimmon fruit, which is highly rich in carotenoids, to dairy products represents an alternative to obtain functional foods. However, carotenoid bioaccessibility is strongly influenced by fat content and food composition. That is why in vitro bioaccessibility of individual carotenoids was evaluated in persimmon-based dairy products formulated with whole (3.6 % fat) or skimmed milk (0.25% fat) and different freeze-dried persimmon tissues. RESULTS: Unambiguous identification of 7 xanthophylls (neoxanthin, violaxanthin, antheraxanthin, lutein, zeaxanthin, lutein epoxide and β-cryptoxanthin) and 3 hydrocarbon carotenes (α-carotene, β-carotene and lycopene) was achieved using high perfomance liquid chromatography with a reverse phase C-30...
December 11, 2017: Journal of the Science of Food and Agriculture
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