Jeeyeon Cha, Xiaofei Sun, Amanda Bartos, Jane Fenelon, Pavine Lefèvre, Takiko Daikoku, Geoff Shaw, Robert Maxson, Bruce D Murphy, Marilyn B Renfree, Sudhansu K Dey
Mammalian embryonic diapause is a phenomenon defined by the temporary arrest in blastocyst growth and metabolic activity within the uterus which synchronously becomes quiescent to blastocyst activation and implantation. This reproductive strategy temporally uncouples conception from parturition until environmental or maternal conditions are favourable for the survival of the mother and newborn. The underlying molecular mechanism by which the uterus and embryo temporarily achieve quiescence, maintain blastocyst survival and then resume blastocyst activation with subsequent implantation remains unknown...
April 24, 2013: Open Biology