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https://www.readbyqxmd.com/read/28630065/ccr5-is-involved-in-interruption-of-pregnancy-in-mice-infected-with-toxoplasma-gondii-during-early-pregnancy
#1
Maki Nishimura, Kousuke Umeda, Masayuki Suwa, Hidefumi Furuoka, Yoshifumi Nishikawa
Toxoplasmosis can cause abortion in pregnant humans and other animals; however, the mechanism of abortion remains unknown. C-C chemokine receptor type 5 (CCR5) is essential for host defense in T. gondii infection. To investigate the relationship between CCR5 and abortion in toxoplasmosis, we inoculated wild-type and CCR5-deficient (CCR5(-/-)) mice with T. gondii tachyzoites intraperitoneally on day 3 of pregnancy (E3). The pregnancy rate decreased as pregnancy progressed in the infected wild-type mice. Histopathologically, no inflammatory lesions were observed in the fetoplacental tissues...
June 19, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28628266/embryo-maternal-dialogue-during-pregnancy-establishment-and-implantation-in-the-pig
#2
REVIEW
Agnieszka Waclawik, Monika M Kaczmarek, Agnieszka Blitek, Piotr Kaczynski, Adam J Ziecik
Porcine conceptuses secrete pregnancy-recognition signals (estrogens, including estradiol-17β) that inhibit luteolysis, thereby prolonging progesterone production by corpora lutea. The supportive mechanism by which the conceptus also inhibits luteolysis is by shifting endometrial prostaglandin (PG) synthesis to luteoprotective PGE2. Progesterone stimulates endometrial production of factors that are essential for conceptus development. Priming the uterus by progesterone and loss of progesterone receptors from the uterine epithelium by D1ay 10-12 after estrus are key for achieving endometrial receptivity for implantation...
June 19, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28628137/-antagonistic-effect-of-quercetin-on-pm2-5-toxicity-in-the-rat-s-embryonic-development-in-vitro
#3
A Q Fan, J Q Feng, W Liu, M J Zhang, T Liu, Y L Zhou, Y J Xu
OBJECTIVE: To explore the antagonistic effect of quercetin on fine particulate matter (PM2.5)-induced embryonic developmental toxicity in vitro. METHODS: PM2.5 was collected on glass fiber filters by PM2.5 samplers during the heating period of Dec. 2015 to Mar. 2016 in an area of Haidian District, Beijing City. The sampled filters were cut into 1 cm×3 cm pieces followed by sonication. The PM2.5 suspension was filtered into a 10 cm glass dish through 8 layers of sterile carbasus and stored at -80 °C until freeze drying...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28620263/immunopathological-response-of-leukocytes-against-microfilariae-and-adult-worms-in-white-rats-infected-with-setaria-cervi
#4
Sharba Kausar, Wajihullah Khan
AIM: Aim of this study was to see the immunopathological changes against the microfilariae (Mf) and adult worms of a bovine filarid, Setaria cervi in the tissues of vital organs of experimentally infected white rats. The effect of diethylcarbamazine (DEC) was also observed on the Mf, as leukocytes especially lymphocytes produce immunoglobulins which opsonize and increase the efficacy of DEC against circulating Mf. Effect of this drug was also assessed on liver enzymes in the microfilaremic rats...
May 2017: Veterinary World
https://www.readbyqxmd.com/read/28611210/hb-egf-regulates-prss56-expression-during-mouse-decidualization-via-egfr-erk-egr2-signaling-pathway
#5
JIe Liu, Fei Gao, Yue-Fang Liu, Hai-Ting Dou, Jia-Qi Yan, Zong-Min Fan, Zeng-Ming Yang
Embryo implantation and decidualization are key steps for successful reproduction. Although numerous factors have been identified to be involved in embryo implantation and decidualization, the mechanisms underlying these processes are still unclear. Based on our preliminary data, Prss56, a trypsin-like serine protease, is strongly expressed at implantation site in mouse uterus. However, the expression, regulation and function of Prss56 during early pregnancy are still unknown. In mouse uterus, Prss56 is strongly expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy compared to inter-implantation site...
June 13, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28588637/effect-of-acupuncture-on-endometrial-angiogenesis-and-uterus-dendritic-cells-in-coh-rats-during-peri-implantation-period
#6
Haoxu Dong, Zhiyan Zhong, Wei Chen, Xiao Wu, Qing Zhang, Guangying Huang, Wei Yang
This study was to explore the mechanism of acupuncture on regulating the endometrial angiogenesis and uterus dendritic cells (uDCs) during the peri-implantation period. Rats, in early pregnancy, were randomized into five groups: normal (N), model (M), acupuncture (A), progesterone (P), and A + P groups. The COH model was established using pregnant mare serum, combined with human chorionic gonadotrophin. Endometrium was collected on days 4, 6, and 8 (D4, D6, and D8) of gestation. Compared with group M, both VEGF and FGF-2 protein and mRNA levels were significantly lower on D4 and higher on D6 and D8 (P < 0...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28584004/vaginal-birth-after-two-previous-caesarean-deliveries-in-a-patient-with-uterus-didelphys-and-an-interuterine-septal-defect
#7
Njoki Ng'ang'a, Jonathan Ratzersdorfer, Yaakov Abdelhak
Uterus didelphys is a congenital abnormality characterised by double uteri, double cervices and a double or single vagina that affects 0.3% to 11% of the general female population. A 23-year-old woman, gravida 3 para 3003, with uterus didelphys, acquired an iatrogenic interuterine septal defect during an otherwise routine primary caesarean delivery for fetal malpresentation. The defect was repaired but noted to have dehisced during her second pregnancy. A repeat caesarean section was performed due to fetal malpresentation after an unsuccessful external cephalic version...
June 5, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28559342/follistatin-is-critical-for-mouse-uterine-receptivity-and-decidualization
#8
Paul T Fullerton, Diana Monsivais, Ramakrishna Kommagani, Martin M Matzuk
Embryo implantation remains a significant challenge for assisted reproductive technology, with implantation failure occurring in ∼50% of in vitro fertilization attempts. Understanding the molecular mechanisms underlying uterine receptivity will enable the development of new interventions and biomarkers. TGFβ family signaling in the uterus is critical for establishing and maintaining pregnancy. Follistatin (FST) regulates TGFβ family signaling by selectively binding TGFβ family ligands and sequestering them...
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28555957/diethylhexyl-phthalate-magnifies-deposition-of-14-c-bisphenol-a-in-reproductive-tissues-of-mice
#9
Evan D Borman, Nicholas Vecchi, Tyler Pollock, Denys deCatanzaro
Endocrine disrupting chemicals are found in diverse common products, including cosmetics, food packaging, thermal receipt paper and plastic containers. This exposes most people in developed countries through ingestion, skin absorption and inhalation. Two ubiquitous endocrine disrupting chemicals, bisphenol A (BPA) and diethylhexyl phthalate (DEHP) can interact in disrupting blastocyst implantation in inseminated females. We hypothesized that DEHP might increase the bioavailability of BPA in tissues by competing for metabolic enzymes...
May 29, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28507287/integrin-beta8-itgb8-activates-vav-rac1-signaling-via-fak-in-the-acquisition-of-endometrial-epithelial-cell-receptivity-for-blastocyst-implantation
#10
Vijay Kumar, Upendra Kumar Soni, Vineet Kumar Maurya, Kiran Singh, Rajesh Kumar Jha
Integrin beta8 (ITGB8) is involved in the endometrial receptivity. The blastocyst first interacts with the luminal endometrial epithelial cells during its implantation; therefore, we have investigated the signaling of ITGB8 via FAK and VAV-RAC1 in the endometrial epithelial cells. Integrin beta8 was found elevated in epithelial cells at late-pre-receptive (day4, 1600 h) and receptive (day5, 0500 h) stages of endometrial receptivity period in the mouse. Integrins downstream molecule FAK has demonstrated an increased expression and phosphorylation (Y397) in the endometrium as well as in the isolated endometrial epithelial cells during receptive and post-receptive stages...
May 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28499799/mouse%C3%A2-rat-aggregation-chimaeras-can-develop-to-adulthood
#11
Katarzyna Bożyk, Katarzyna Gilecka, Monika Humięcka, Marcin Szpila, Aneta Suwińska, Andrzej K Tarkowski
In order to examine interactions between cells originating from different species during embryonic development we constructed interspecific mouse↔rat chimaeras by aggregation of 8-cell embryos. Embryos of both species expressed different fluorescent markers (eGFP and DsRed), which enabled us to follow the fate of both components from the moment of aggregation until adulthood. We revealed that in majority of embryos the blastocyst cavity appeared inside the group of rat cells, while the mouse component was allocated to the deeper layer of the inner cell mass and to the polar trophectoderm...
May 9, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28498625/biomechanics-of-the-human-uterus
#12
REVIEW
Kristin M Myers, David Elad
The appropriate biomechanical function of the uterus is required for the execution of human reproduction. These functions range from aiding the transport of the embryo to the implantation site, to remodeling its tissue walls to host the placenta, to protecting the fetus during gestation, to contracting forcefully for a safe parturition and postpartum, to remodeling back to its nonpregnant condition to renew the cycle of menstruation. To serve these remarkably diverse functions, the uterus is optimally geared with evolving and contractile muscle and tissue layers that are cued by chemical, hormonal, electrical, and mechanical signals...
May 12, 2017: Wiley Interdisciplinary Reviews. Systems Biology and Medicine
https://www.readbyqxmd.com/read/28493788/development-of-in-vitro-embryo-production-system-using-collagen-matrix-gel-attached-vascular-endothelial-growth-factor-derived-from-interleukin-1-beta-treated-porcine-endometrial-tissue
#13
Hye-In Han, Sang-Hee Lee, Choon-Keun Park
The aim of this study was to establish an embryo culture system using collagen gel attached with vascular endothelial growth factor (VEGF) derived from interleukin-1 beta (IL-1β)-treated endometrial tissues from pigs. Endometria were separated from the porcine uterus at the follicular phase of the estrous cycle and were cultured with IL-1β. The collagen gels co-incubated with IL-1β-treated endometria (C, without endometrial tissue; CE, with endometrial tissue; and CEI, IL-1β-treated endometrial tissue) were used for embryo culture...
May 11, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28487952/expression-of-reproductive-hormone-receptors-and-contraction%C3%A2-associated-genes-in-porcine-uterus-during-the-estrous-cycle
#14
Sung-Min An, Sun Suk Kim, Jun Kim, Mee-Na Park, Jae-Eon Lee, Seong Keun Cho, Kyu-Sup Lee, Beum-Soo An
Contraction of uterus tissue frequently occurs throughout the estrous cycle and is regulated by several endogenous factors, including estradiol, progesterone, luteinizing hormone, follicle‑stimulating hormone, oxytocin (OXT) and contraction‑associated proteins (CAPs). Contraction activity of uterus tissue according to the estrous cycle is important, due to the fact that it is directly associated with balanced implantation and stable pregnancy. However, few studies have examined the mechanism of uterus contraction activity in a porcine model...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28478820/down-regulation-of-hla-g-gene-expression-as-an-immunogenetic-contraceptive-therapy
#15
Valéria Kaminski, Joel Henrique Ellwanger, José Artur Bogo Chies
HLA-G is a nonclassical HLA immunotolerogenic molecule expressed in different human cell types. Successful embryo implantation is a consequence of information exchange between the uterus and the blastocyst. It is widely accepted that HLA-G expression by the fetus promotes the establishment of several mechanisms that, ultimately, would protect the developing embryo from maternal immune rejection and seems to be essential to both an adequate implantation and a healthy pregnancy. MicroRNAs miR-148a and miR-152 down-regulate HLA-G expression...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28466234/the-bovine-embryo-hatches-from-the-zona-pellucida-through-either-the-embryonic-or-abembryonic-pole
#16
Verónica M Negrón-Pérez, Peter J Hansen
PURPOSE: Implantation of the mammalian embryo in the uterus is preceded by escape from the zona pellucida. In some species, hatching from the zona occurs preferentially from one or the other poles of the embryo. The situation for the bovine embryo, in which hatching precedes attachment to the uterus by more than a week, is unclear. The purpose was to describe whether hatching of the bovine embryo from the zona pellucida occurs preferentially from the embryonic or abembryonic pole. METHODS: Bovine blastocysts undergoing hatching were examined by light microscopy (n = 84) and epifluorescence imaging using antibodies for markers of epiblast, hypoblast, and trophectoderm (TE) (n = 26)...
June 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28464910/intracerebroventricular-injection-of-rfrp-3-delays-puberty-onset-and-stimulates-growth-hormone-secretion-in-female-rats
#17
Xinghui Han, Yuanyuan He, Gulan Zeng, Yonghong Wang, Wen Sun, Junchao Liu, Yanyan Sun, Jian Yu
BACKGROUND: Puberty onset is a complex, organized biological process with multilevel regulation, and its physiopathological mechanisms are yet to be elucidated. RFRP-3, the mammalian ortholog to gonadotropin-inhibitory hormone, is implicated in inhibiting the synthesis and release of gonadotropin in mammals. However, it is unclear whether RFRP-3 participates in regulating pubertal development. METHODS: This study investigated the functional significance and regulatory mechanism of hypothalamic RFRP-3 neuropeptide in the onset of puberty in young female rats...
May 2, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28458160/resveratrol-and-endometriosis-in-vitro-and-animal-studies-and-underlying-mechanisms-review
#18
REVIEW
Roya Kolahdouz Mohammadi, Tahereh Arablou
Endometriosis is characterized by the existence of endometrial tissue and stroma exterior to the uterus. Despite the high prevalence, the etiology of endometriosis remains elusive. The search for the most promising compounds for treatment of endometriosis has led to the identification of resveratrol. Resveratrol, a plant-derived polyphenolic phytoalexin, demonstrates broad-spectrum health beneficial effects, including anti-proliferative, anti-inflammatory, antineoplastic and antioxidant. Because of these properties and its wide distribution in plants, resveratrol is proposed as a great potential to treat endometriosis...
July 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28442048/expression-of-17%C3%AE-hydroxysteroid-dehydrogenase-and-the-effects-of-lh-fsh-and-prolactin-on-oestrone-and-17%C3%AE-oestradiol-secretion-in-the-endometrium-of-pigs-during-early-pregnancy-and-the-oestrous-cycle
#19
B Wojciechowicz, G Kotwica, K Zglejc, E Waszkiewicz, A Franczak
The endometrium of pregnant and cyclic pigs is a source of oestrone (E1) and 17β-oestradiol (E2). However, the roles of LH, FSH and prolactin (PRL) as regulators of endometrial steroidogenesis, and the presence of 17β-hydroxysteroid dehydrogenase (17β-HSD) in the porcine endometrium, remain unknown. Therefore, in the present study we examined 17β-HSD expression and the effects of LH, FSH and PRL on E1 and E2 release in vitro in endometrial explants harvested from gravid pigs on Days 10-11 (embryo migration within the uterus), 12-13 (maternal recognition of pregnancy) and 15-16 (beginning of implantation) and compared them with results obtained in non-gravid pigs...
April 2017: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/28431985/quercetin-interferes-with-the-fluid-volume-and-receptivity-development-of-the-uterus-in-rats-during-the-peri-implantation-period
#20
Huma Shahzad, Nelli Giribabu, Kamarulzaman Karim, Normadiah Kassim, Sekaran Muniandy, Kilari Eswar Kumar, Naguib Salleh
HYPOTHESIS: Quercetin could induce changes to the fluid volume and receptivity development of the uterus during peri-implantation period. METHODS: Female rats were treated with quercetin (10, 25 and 50mg/kg/day) subcutaneously beginning from day-1 pregnancy. Uterus was harvested at day-4 (following three days quercetin treatment) for morphological, ultra-structural, protein and mRNA expressional changes and plasma sex-steroid levels analyses. In another cohort of rats, implantation rate was determined at day-6 (following five days quercetin treatment)...
April 18, 2017: Reproductive Toxicology
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