keyword
https://read.qxmd.com/read/32444974/adipose-derived-mesenchymal-stem-cell-treatment-in-experimental-asherman-syndrome-induced-rats
#21
JOURNAL ARTICLE
Nazlı Çil, Mutlu Yaka, Murat Serkant Ünal, Yavuz Dodurga, Semih Tan, Mücahit Seçme, Ege Rıza Karagür, Gülçin Abban Mete
Asherman syndrome (AS) occurs due to fibrosis or uterine adhesions as a result of damage to the basal layer of the endometrium. The aim of this study is investigating the effects of adipose tissue-derived mesenchymal stem cell (ADMSC) application on the expression of vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF-1), miRNA-98, miRNA199a in endometrial tissue in rats with AS. Study groups were designed as, control (C), Asherman syndrome (AS), AS + oral estrogen (ASO), AS + ADMSC (ASSC), AS + oral estrogen + ADMSC (ASSCO) with 7 samples in each group...
May 22, 2020: Molecular Biology Reports
https://read.qxmd.com/read/32401642/autophagy-in-the-physiological-endometrium-and-cancer
#22
REVIEW
Laura Devis-Jauregui, Núria Eritja, Meredith Leigh Davis, Xavier Matias-Guiu, David Llobet-Navàs
Autophagy is a highly conserved catabolic process and a major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. An increasing body of evidence has unveiled autophagy as an indispensable biological function that helps to maintain normal tissue homeostasis and metabolic fitness that can also lead to severe consequences for the normal cellular functioning when altered. Recent accumulating data point to autophagy as a key player in a wide variety of physiological and pathophysiological conditions in the human endometrium, one of the most proficient self-regenerating tissues in the human body and an instrumental player in placental species reproductive function...
May 2021: Autophagy
https://read.qxmd.com/read/30197147/effects-of-altering-the-ratio-of-dietary-n-6-to-n-3-fatty-acids-on-spontaneous-luteolysis-in-lactating-dairy-cows
#23
JOURNAL ARTICLE
L F Greco, J T Neves Neto, A Pedrico, F S Lima, R S Bisinotto, N Martinez, E S Ribeiro, W W Thatcher, C R Staples, J E P Santos
Objectives were to evaluate the effects of altering the dietary ratio of omega-6 (n-6) to omega-3 (n-3) fatty acids on the profile of fatty acids and expression of genes related to the prostaglandin biosynthesis on endometrial tissue, uterine secretion of PGF2α , and timing of spontaneous luteolysis in dairy cows. Multiparous lactating Holstein cows (n = 45) were blocked based on milk yield and, within each block, assigned randomly to 1 of 3 dietary treatments at 14 d postpartum for 90 d. Diets were supplemented with a mixture of Ca salts of fish, safflower, and palm oils to create 3 different ratios of n-6 to n-3 fatty acids, namely R4, R5, and R6, which resulted in 3...
November 2018: Journal of Dairy Science
https://read.qxmd.com/read/30044147/endometrium-receptivity-in-premature-ovarian-insufficiency-how-to-improve-fertility-rate-and-predict-diseases
#24
REVIEW
Svetlana Vujović, Miomira Ivovic, Milina Tančić-Gajić, Ljiljana Marina, Aleksandar Ljubic, Svetlana Dragojević-Dikić, Andrea Ricardo Genazzani
More empathized approach is required and is obligatory to women with premature ovarian insufficiency (POI) interested for pregnancy. In order to improve fertility rate in POI patients our suggestions would be: (1) To decrease FSH value to 10-15 IU/L by increasing estrogen. Oocyte donation can be suggested after a minimum of six month interval from FSH between 10-15 IU/L and when no dominant follicles are found. (2) To perform oral glucose tolerance test (OGTT). Insulin sensitizing agents has to be included, when indicated, 3-6 month before pregnancy...
December 2018: Gynecological Endocrinology
https://read.qxmd.com/read/29210631/uterine-function-from-normal-to-polycystic-ovarian-syndrome-alterations
#25
REVIEW
Silvana R Ferreira, Alicia B Motta
BACKGROUND: The endometrium is one of the most important female reproductive organs. Polycystic ovarian syndrome (PCOS) is a reproductive and endocrine pathology that affect women of reproductive age. PCOS negatively affects the endometrium, leading to implantation failure and proliferative aberrations. METHODS: We conducted a search at the https://www.ncbi.nlm.nhi.gov/pubmed/electronic database using the following key words: endometrial steroid receptors, endometrium, uterine function, endometrium and PCOS, implantation window, implantation and PCOS, implantation markers, inflammation, oxidative stress...
2018: Current Medicinal Chemistry
https://read.qxmd.com/read/29133384/estrogen-and-high-fat-diet-induced-alterations-in-c57bl-6-mice-endometrial-transcriptome-profile
#26
JOURNAL ARTICLE
Yali Cheng, Qiaoying Lv, Bingying Xie, Bingyi Yang, Weiwei Shan, Chengcheng Ning, Bing Li, Liying Xie, Chao Gu, Xuezhen Luo, Xiaojun Chen, Qin Zhu
Unopposed estrogen stimulation and insulin resistance are known to play important roles in endometrial cancer (EC), but the interaction between these two factors and how they contribute to endometrial lesions are not completely elucidated. To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance...
January 2018: Endocrine Connections
https://read.qxmd.com/read/28868248/the-window-of-implantation-is-closed-by-estrogen-via-insulin-like-growth-factor-1-pathway
#27
JOURNAL ARTICLE
Ryosuke Kobayashi, Jumpei Terakawa, Tsutomu Omatsu, Yupadee Hengjan, Tetsuya Mizutani, Yasushige Ohmori, Eiichi Hondo
BACKGROUND: The opening and closing of the implantation window is important for successful pregnancy in eutherians. The recent study demonstrated that the window of uterine receptivity was prepared by the sole action of progesterone in mice, but the mechanism to close the window remained to be elucidated. METHODS: The pregnant mice were ovariectomized on the evening on the third day of pregnancy with a single injection of medroxyprogesterone acetate to induce delayed implantation (DI)...
April 2017: Journal of Reproduction & Infertility
https://read.qxmd.com/read/28447735/mice-endometrium-receptivity-in-early-pregnancy-is-impaired-by-maternal-hyperinsulinemia
#28
JOURNAL ARTICLE
Runqin Li, Juan Wu, Junlin He, Yingxiong Wang, Xueqing Liu, Xuemei Chen, Chao Tong, Yubin Ding, Yan Su, Wenqi Chen, Chen Zhang, Rufei Gao
Previous studies have investigated the lower embryo implantation rates in women with polycystic ovary syndrome, obesity and type 2 diabetes, and specifically the association between the abnormal oocyte and embryo and hyperinsulinemia. The importance of hyperinsulinemia on maternal endometrium receptivity remains to be elucidated. The present study used a hyperinsulinemic mouse model to determine whether hyperinsulinemia may affect endometrial receptivity. An insulin intervention mouse model was first established...
May 2017: Molecular Medicine Reports
https://read.qxmd.com/read/28382153/increased-tet1-expression-in-inflammatory-microenvironment-of-hyperinsulinemia-enhances-the-response-of-endometrial-cancer-to-estrogen-by-epigenetic-modulation-of-gper
#29
JOURNAL ARTICLE
Qiao-Ying Lv, Bing-Ying Xie, Bing-Yi Yang, Cheng-Cheng Ning, Wei-Wei Shan, Chao Gu, Xue-Zhen Luo, Xiao-Jun Chen, Zhen-Bo Zhang, You-Ji Feng
Background: Insulin resistance (IR) has been well studied in the initiation and development of endometrial endometrioid carcinoma (EEC). As yet, it has been largely neglected for estrogen sensitivity in local endometrium in hyperinsulinemia-induced systemic microenvironment. The aim of this study was to investigate the role of insulin in regulating estrogen sensitivity and explore the potential mechanisms in insulin-driven inflammatory microenvironment. Methods: We first investigated the effect of insulin on estradiol-driven endometrial cancer cells proliferation in vitro to address the roles of insulin in modulating estrogen sensitivity...
2017: Journal of Cancer
https://read.qxmd.com/read/27859423/from-obesity-to-cancer-a-review-on-proposed-mechanisms
#30
REVIEW
Zoya Tahergorabi, Majid Khazaei, Mitra Moodi, Elham Chamani
Nowadays, obesity is considered as a serious and growing global health problem. It is documented that the overweight and obesity are major risk factors for a series of noncommunicable diseases, and in recent years, the obesity-cancer link has received much attention. Numerous epidemiological studies have shown that obesity is associated with increased risk of several cancer types, including colon, breast, endometrium, liver, kidney, esophagus, gastric, pancreatic, gallbladder, and leukemia, and can also lead to poorer treatment...
December 2016: Cell Biochemistry and Function
https://read.qxmd.com/read/27845161/downregulation-of-autophagy-gene-expression-in-endometria-from-women-with-polycystic-ovary-syndrome
#31
JOURNAL ARTICLE
Mirjana Sumarac-Dumanovic, Milica Apostolovic, Kristina Janjetovic, Danka Jeremic, Dusan Popadic, Aleksandar Ljubic, Jelena Micic, Jelena Dukanac-Stamenkovic, Aleksandra Tubic, Darko Stevanovic, Dragan Micic, Vladimir Trajkovic
Autophagy, a process of controlled cellular self-digestion, could be involved in cyclic remodeling of the human endometrium. We investigated endometrial mRNA expression of 23 autophagy-related (ATG) genes and transcription factors in healthy controls (n = 12) and anovulatory polycystic ovary syndrome (PCOS) patients (n = 24), as well as in their subgroup (n = 12) before and after metformin treatment. The mRNA levels of transcription factor forkhead box protein O1 (FOXO1) and several molecules involved in autophagosome formation (ATG13, RB1-inducible coiled-coil 1), autophagosome nucleation (ATG14, beclin 1, SH3-domain GRB2-like endophilin B1), autophagosome elongation (ATG3, ATG5, γ-aminobutyric acid receptor-associated protein - GABARAP), and delivery of ubiquitinated proteins to autophagosomes (sequestosome 1), were significantly reduced in anovulatory PCOS compared to healthy endometrium...
January 15, 2017: Molecular and Cellular Endocrinology
https://read.qxmd.com/read/27636742/metformin-inhibits-estrogen-dependent-endometrial-cancer-cell-growth-by-activating-the-ampk-foxo1-signal-pathway
#32
JOURNAL ARTICLE
Jingfang Zou, Liangli Hong, Chaohuan Luo, Zhi Li, Yuzhang Zhu, Tianliang Huang, Yongneng Zhang, Huier Yuan, Yaqiu Hu, Tengfei Wen, Wanling Zhuang, Bozhi Cai, Xin Zhang, Jiexiong Huang, Jidong Cheng
Metformin is an oral biguanide commonly used for treating type II diabetes and has recently been reported to possess antiproliferative properties that can be exploited for the prevention and treatment of a variety of cancers. The mechanisms underlying this effect have not been fully elucidated. Our study shows a marked loss of AMP-activated protein kinase (AMPK) phosphorylation and nuclear human Forkhead box O1 (FOXO1) protein in estrogen-dependent endometrial cancer (EC) tumors compared to normal control endometrium...
December 2016: Cancer Science
https://read.qxmd.com/read/27325575/gestation-related-gene-expression-and-protein-localization-in-endometrial-tissue-of-suffolk-and-cheviot-ewes-at-gestation-day-19-after-transfer-of-suffolk-or-cheviot-embryos
#33
JOURNAL ARTICLE
M Sequeira, S J Pain, V de Brun, A Meikle, P R Kenyon, H T Blair
The objective of this study was to investigate the gene expression of progesterone and estrogen receptor α (PR, ERα), insulin-like growth factor (IGF) 1, IGF-2, their receptor (IGFR1), IGF-binding proteins (BP) 1 to 6, insulin receptor, adiponectin receptors (AdipoR1/2), cyclooxygenase 2 (PTGS2), mucin 1 and to localize PR, ERα, IGF-1, IGFR1, PTGS2, and proliferating cellular nuclear antigen (PCNA) in the endometrium of pregnant (Day 19) Suffolk and Cheviot ewes carrying Suffolk and Cheviot embryos transferred within and reciprocally between breeds...
October 1, 2016: Theriogenology
https://read.qxmd.com/read/27156350/polycystic-ovary-syndrome-endometrial-markers
#34
REVIEW
Terhi T Piltonen
Women with polycystic ovarian syndrome (PCOS) present with several endometrial abnormalities possibly explaining some of the adverse endometrium-related outcomes in these women. PCOS and an increased miscarriage rate have been suggested to coincide, but the results are conflicting. Recent studies have also shown increased risks of pregnancy-induced hypertension, preeclampsia, and premature delivery that may be related to altered decidualization/placentation in affected women. In the long run, PCOS per se is associated with the occurrence of endometrial cancer (EC), with obesity aggravating the risk...
November 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/27125830/insulin-igf-and-sex-hormone-axes-in-human-endometrium-and-associations-with-endometrial-cancer-risk-factors
#35
JOURNAL ARTICLE
Melissa A Merritt, Howard D Strickler, Mark H Einstein, Hannah P Yang, Mark E Sherman, Nicolas Wentzensen, Jurriaan Brouwer-Visser, Maria Jose Cossio, Kathleen D Whitney, Herbert Yu, Marc J Gunter, Gloria S Huang
PURPOSE: Experimental and observational data link insulin, insulin-like growth factor (IGF), and estrogens to endometrial tumorigenesis. However, there are limited data regarding insulin/IGF and sex hormone axes protein and gene expression in normal endometrial tissues, and very few studies have examined the impact of endometrial cancer risk factors on endometrial tissue biology. METHODS: We evaluated endometrial tissues from 77 premenopausal and 30 postmenopausal women who underwent hysterectomy for benign indications and had provided epidemiological data...
2016: Cancer Causes & Control: CCC
https://read.qxmd.com/read/27088794/differential-expression-of-ir-a-ir-b-and-igf-1r-in-endometrial-physiology-and-distinct-signature-in-adenocarcinoma
#36
JOURNAL ARTICLE
Clare A Flannery, Farrah L Saleh, Gina H Choe, Daryl J Selen, Pinar H Kodaman, Harvey J Kliman, Teresa L Wood, Hugh S Taylor
CONTEXT: Type 2 diabetes and obesity are risk factors for endometrial hyperplasia and cancer, suggesting that hyperinsulinemia contributes to pathogenesis. Insulin action through insulin receptor (IR) splice variants IR-A and IR-B regulates cellular mitogenesis and metabolism, respectively. OBJECTIVE: We hypothesized that IR-A and IR-B are differentially regulated in normal endometrium, according to mitogenic and metabolic requirements through the menstrual cycle, as well as in endometrial hyperplasia and cancer...
July 2016: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/26841672/-the-characteristics-of-systemic-and-local-immune-reactions-under-habitual-non-carrying-of-pregnancy
#37
JOURNAL ARTICLE
S Yu Yuriev, I S Popova, L R Mustafina, I A Zakonova, A E Sazonov, A B Poletaev
The study was carried out to evaluate clinical informativeness ofstudies of immunological parameters of structural and functional elements of endometrium in complex with profile of embritropic autoimmune antibodies under non-carrying of pregnancy The sampling consisted of 19 women of reproductive age with episodes of non-carrying in first semester. They were examined for inherited thrombophilia and profiles of immune reactivity of natural regulatory auto-antibodies (ELI-P-Complex). The biopsy material of endometrium was subjected to histological and immune histochemical (CD16, CD56, CD68, CB138, estrogen and progesterone receptors) analyses...
October 2015: Klinicheskaia Laboratornaia Diagnostika
https://read.qxmd.com/read/26548420/protective-effects-of-bazedoxifene-paired-with-conjugated-estrogens-on-pancreatic-%C3%AE-cell-dysfunction
#38
Jun Ho Kim, Jin Hyup Lee, Young Jun Kim
Bazedoxifene (BZA) is a novel selective estrogen receptor modulator that exhibits estrogen agonist activity in the bone but estrogen antagonist activity in the breast and uterus. We recently demonstrated that BZA mimics estrogenic actions in reversing metabolic abnormalities while protecting the endometrium from estrogen stimulation in ovariectomized (OVX) mice. However, it is unknown whether BZA, alone or paired with estrogens, can protect pancreatic β-cell function or survival. Thus, the aim of this study was to evaluate the preventive effects of estrogens [17β-estradiol or conjugated estrogens (CE)], BZA and their combinations against β-cell failure...
November 6, 2015: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/26021997/bisphenol-a-modulates-receptivity-and-secretory-function-of-human-decidual-cells-an-in-vitro-study
#39
JOURNAL ARTICLE
Chiara Mannelli, Anna Z Szóstek, Karolina Lukasik, Claudiopietro Carotenuto, Francesca Ietta, Roberta Romagnoli, Cristina Ferretti, Luana Paulesu, Slawomir Wołczynski, Dariusz Jan Skarzynski
The human endometrium is a fertility-determining tissue and a target of steroid hormones' action. Endocrine disruptors (EDs) can exert adverse effects on the physiological function of the decidua at the maternal-fetal interface. We examined the potential effects of an ED, bisphenol A (BPA), on endometrial maturation/decidualization, receptivity, and secretion of decidual factors (biomarkers). In vitro decidualized, endometrial stromal cells from six hysterectomy specimens were treated with 1  pM-1  μM of BPA, for 24  h and assessed for cell viability and proliferation...
August 2015: Reproduction
https://read.qxmd.com/read/25866823/the-association-between-type-2-diabetes-mellitus-and-women-cancer-the-epidemiological-evidences-and-putative-mechanisms
#40
REVIEW
Kyong Hye Joung, Jae-Wook Jeong, Bon Jeong Ku
Type 2 diabetes mellitus (T2DM), a chronic disease increasing rapidly worldwide, is well established as an important risk factor for various types of cancer. Although many factors impact the development of T2DM and cancer including sex, age, ethnicity, obesity, diet, physical activity levels, and environmental exposure, many epidemiological and experimental studies are gradually contributing to knowledge regarding the interrelationship between DM and cancer. The insulin resistance, hyperinsulinemia, and chronic inflammation associated with diabetes mellitus are all associated strongly with cancer...
2015: BioMed Research International
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