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Sclerotic bone metastasis

Nikolaas De Maeyer, Walter De Wever, Christophe M Deroose, Johan Vansteenkiste
No abstract text is available yet for this article.
August 24, 2016: Journal of Thoracic Oncology
Nicholas Chiu, Linda Probyn, Srinivas Raman, Rachel McDonald, Ian Poon, Darby Erler, Drew Brotherston, Hany Soliman, Patrick Cheung, Hans Chung, William Chu, Andrew Loblaw, Nemica Thavarajah, Catherine Lang, Lee Chin, Edward Chow, Arjun Sahgal
BACKGROUND: In recent years, stereotactic body radiation therapy (SBRT) has become increasingly used for the management of non-spine bone metastases. Few studies have examined the radiological changes in bone metastases after treatment with SBRT and there is no consensus about what constitutes radiologic response to therapy. This article describes various changes on CT after SBRT to non-spine bone metastases in eight selected cases. METHODS: A retrospective review was conducted for patients treated with SBRT to non-spine bone metastases between November 2011 and April 2014 at Sunnybrook Health Sciences Centre...
April 2016: Annals of Palliative Medicine
Selene Capitanio, Francesca Bongioanni, Arnoldo Piccardo, Claudio Campus, Roberta Gonella, Lucia Tixi, Mehrdad Naseri, Michele Pennone, Vania Altrinetti, Ambra Buschiazzo, Irene Bossert, Francesco Fiz, Andrea Bruno, Andrea DeCensi, Gianmario Sambuceti, Silvia Morbelli
AIM: To compare 2-deoxy-2-((18)F)fluoro-D-glucose((18)F-FDG) and (18)F-sodium ((18)F-NaF) positron emission tomography/computed tomography (PET/CT) accuracy in breast cancer patients with clinically/radiologically suspected or known bone metastases. METHODS: A total of 45 consecutive patients with breast cancer and the presence or clinical/biochemical or radiological suspicion of bone metastatic disease underwent (18)F-FDG and (18)F-fluoride PET/CT. Imaging results were compared with histopathology when available, or clinical and radiological follow-up of at least 1 year...
February 28, 2016: World Journal of Radiology
Charles P Fischer, Peter C Emary, John A Taylor
OBJECTIVE: The purpose of this report is to present a presumptive case of ankylosing spondylitis with late stage progression that simulated osteoblastic metastasis in a patient with a history of prostate carcinoma. CLINICAL FEATURES: A 67-year-old white man presented to a chiropractic clinic complaining of severe and worsening acute low back pain and right foot "numbness." Further questioning also revealed a history of prostate carcinoma. INTERVENTION AND OUTCOME: Imaging examination revealed a sclerotic pedicle and increased uptake of radiopharmaceutical on a nuclear medicine bone scan highly suggestive of osteoblastic skeletal metastasis...
December 2015: Journal of Chiropractic Medicine
Jgirim Mahbouba, Golli Mondher, Mhenni Amira, Manari Walid, Bergaoui Naceur
BACKGROUND: Osteopoikilosis (OPK) is a rare inherited condition of the bones, transmitted as an autosomal dominant trait characterized by numerous hyperostotic areas that tend to localize in periarticular osseous regions. It is usually asymptomatic and is often diagnosed incidentally during x-rays made by other reasons. We present a case of 34-year-old man suffering from polyarthralgia and low back pain. CASE PRESENTATION: A 34-year-old male patient, smoking 40 packs yearly and alcoholic was referred to our department of rheumatology, complaining of polyarthralgia which started 3 years ago and involving large and small joints...
2015: Caspian Journal of Internal Medicine
Malin Hagberg Thulin, Maria E Nilsson, Pontus Thulin, Jocelyn Céraline, Claes Ohlsson, Jan-Erik Damber, Karin Welén
The skeleton is the preferred site for prostate cancer (PC) metastasis leading to incurable castration-resistant disease. The increased expression of genes encoding steroidogenic enzymes found in bone metastatic tissue from patients suggests that up-regulated steroidogenesis might contribute to tumor growth at the metastatic site. Because of the overall sclerotic phenotype, we hypothesize that osteoblasts regulate the intratumoral steroidogenesis of castration resistant prostate cancer (CRPC) in bone. We here show that osteoblasts alter the steroidogenic transcription program in CRPC cells, closely mimicking the gene expression pattern described in CRPC...
February 15, 2016: Molecular and Cellular Endocrinology
Zeyad Al-Ogaili, Russell Troedson
INTRODUCTION: The aim of this study is to identify and describe the computed tomography and scintigraphic imaging patterns of osseous metastasis from invasive lobular breast cancer (ILC). MATERIALS AND METHODS: CT and skeletal scintigraphy (SS) studies of 23 patients with diagnosis of ILC and osseous metastasis on their initial presentation were reviewed. RESULTS: Osseous metastases in 14 patients (60.8%) appear as uniform small sclerotic lesions (USSL) on CT scan...
February 2016: Journal of Medical Imaging and Radiation Oncology
Ezgi Basak Erdogan, Nur Buyukpinarbasili, Sedat Ziyade, Tolga Akman, Haci Mehmet Turk, Mehmet Aydin
A 71-year-old male patient with solitary pulmonary nodule underwent fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) showing slightly increased FDG uptake in this nodule. In addition, PET/CT detected hypermetabolic sclerotic bone lesions in the right second rib and 7(th) thoracic vertebrae, which were interpreted as possible metastases, and mildly increased FDG uptake in the prostate gland highly suspicious of malignancy. The patient's prostate-specific antigen (PSA) level was within normal range (3...
July 2015: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Hye Min Kim, Woo Hee Jung, Ja Seung Koo
BACKGROUND: Cancer-associated fibroblast (CAF) is the most studied element of the tumor microenvironment, although no relationship has been identified between expression of their related proteins and the metastasis site. The purpose of this study was to investigate the expression of CAF related proteins and their implications according to the metastasis site in metastatic breast cancer. METHODS: Immunohistochemical staining was used to evaluate the expression of CAF related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFRα, PDGFRβ, and NG2) in tissue microarrays from 132 cases of metastatic breast cancer (bone metastasis: 32 cases, brain metastasis: 38 cases, liver metastasis: 10 cases, and lung metastasis: 52 cases)...
2015: Journal of Translational Medicine
Brittany Z Dashevsky, Debra A Goldman, Molly Parsons, Mithat Gönen, Adriana D Corben, Maxine S Jochelson, Clifford A Hudis, Monica Morrow, Gary A Ulaner
PURPOSE: To determine if the histology of a breast malignancy influences the appearance of untreated osseous metastases on FDG PET/CT. METHODS: This retrospective study was performed under IRB waiver. Our Hospital Information System was screened for breast cancer patients who presented with osseous metastases, who underwent FDG PET/CT prior to systemic therapy or radiotherapy from 2009 to 2012. Patients with invasive ductal carcinoma (IDC), invasive lobular carcinoma (ILC), or mixed ductal/lobular (MDL) histology were included...
October 2015: European Journal of Nuclear Medicine and Molecular Imaging
Arisa Kato, Mizuki Yutani, Mika Terao, Akihiro Kimura, Saori Itoi, Hiroyuki Murota, Eiji Miyoshi, Ichiro Katayama
Oligosaccharide modification by N-acetylglucosaminyltransferase-V (GnT-V), which catalyses the formation of β1,6 GlcNAc (N-acetylglucosamine) branches on N-glycans, is associated with various pathologies, such as cancer metastasis, multiple sclerosis and liver fibrosis. In this study, we demonstrated the involvement of GnT-V in the pathophysiology of scleroderma. High expression of GnT-V was observed in infiltrating cells in skin section samples from systemic and localized patients with scleroderma. Most of the infiltrating cells were T cells and macrophages, most of which were CD163(+) M2 macrophages...
August 2015: Experimental Dermatology
Vivek Ajit Singh, Amber Haseeb, Alla Allden H Ali Alkubaisi
INTRODUCTION: Morbidity and mortality from malignant diseases are usually the result of metastasis. The bone is the third most common site of metastasis. METHODS: This is a retrospective study of patients with metastatic bone disease who were referred to the Orthopaedic Department of University Malaya Medical Centre, Malaysia, between January 2004 and October 2009. RESULTS: A total of 151 patients (51.0% men, 49.0% women) had metastatic bone disease, with the highest incidence at the age range of 50-59 years...
October 2014: Singapore Medical Journal
Georg Homann, Deedar F Mustafa, Hendrik Ditt, Werner Spengler, Hans-Georg Kopp, Konstantin Nikolaou, Marius Horger
RATIONALE AND OBJECTIVES: To evaluate the performance of a dedicated computed tomography (CT) software called "bone reading" generating rib unfolded images for improved detection of rib metastases in patients with lung cancer in comparison to readings of 5- and 1-mm axial CT images and (18)F-Fluordeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT). MATERIALS AND METHODS: Ninety consecutive patients who underwent (18)F-FDG-PET/CT and chest CT scanning between 2012 and 2014 at our institution were analyzed retrospectively...
April 2015: Academic Radiology
Samer AlSamman, Soumya Parimi, Mohd Amer AlSamman
SESSION TITLE: Miscellaneous Student/Resident Case Report Posters ISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Sarcoidosis is a granulomatous disease that typically occurs in lungs but can present with extrapulmonary manifestations. Skeletal involvement is rare, and usually associated with skin manifestations. This is a rare case of extrapulmonary sarcoidosis with axial bone disease and no lung involvement...
October 1, 2014: Chest
Seok-Ho Yoon, Ku Sang Kim, Seok Yun Kang, Hee-Sung Song, Kyung Sook Jo, Bong-Hoi Choi, Su Jin Lee, Joon-Kee Yoon, Young-Sil An
PURPOSE: Bone metastasis is an important factor for the treatment and prognosis of breast cancer patients. Whole-body bone scintigraphy (WBBS) can evaluate skeletal metastases, and (18)F-FDG PET/CT seems to exhibit high specificity and accuracy in detecting bone metastases. However, there is a limitation of (18)F-FDG PET in assessing sclerotic bone metastases because some lesions may be undetectable. Recent studies showed that (18)F-fluoride PET/CT is more sensitive than WBBS in detecting bone metastases...
March 2013: Nuclear Medicine and Molecular Imaging
S Colangeli, G Rossi, R Ghermandi, E Rimondi
INTRODUCTION: Spinal bone metastases may be lytic or sclerotic lesions. Sometimes aneurismal bone cyst (ABC)-like areas (also called "secondary ABC") can be found in giant-cell tumors, osteoblastomas and chondroblastomas but are rare in metastatic tumors. CASE REPORT: A retrospective study on 518 patients surgically treated for metastatic lesions of the spine from 1995 to 2012 was performed to evaluate the radiographic presentation. We propose a case report of a metastatic lesion associated with imaging features suggestive of aneurismal bone cyst...
2014: European Review for Medical and Pharmacological Sciences
Terry H Landowski, Jaime Gard, Erika Pond, Gerald D Pond, Raymond B Nagle, Christopher P Geffre, Anne E Cress
Laminin-binding integrin receptors are key mediators of epithelial cell migration and tumor metastasis. Recent studies have demonstrated a role for the α6 integrin (ITGA6/CD49f) in maintaining stem cell compartments within normal bone marrow and in residency of tumors metastatic to bone. In this study, we tested a function-blocking antibody specific for ITGA6, called J8H, to determine if preexisting cancer lesions in bone could be slowed and/or animal survival improved. Human prostate tumors were established by intracardiac injection into male SCID mice and treatment with J8H antibody was initiated after 1 week...
June 2014: Molecular Cancer Therapeutics
Robert P Jones, Andrei Iagaru
A 57-year-old man with a history of metastatic melanoma and sclerotic bone lesions seen on CT was referred for F NaF PET/CT evaluation of active skeletal metastases. While the bone lesions had no uptake and were therefore thought to represent sequela of previously treated disease, an unexpected area of F NaF uptake was identified in the left temporal lobe. Concurrent contrast-enhanced brain MRI re-demonstrated a large metastasis, also seen on previous MRI scans done at another institution.
October 2014: Clinical Nuclear Medicine
E J Mahdi, A J Mahdi
The association of metastatic breast cancer presenting as thrombocytopenia and anaemia is demonstrated in the following case of a 79-year-old woman. Her main symptoms were abdominal pain, altered bowel habit and weight loss. Without a clear causative pathology, she underwent a CT scan which demonstrated multiple sclerotic bone lesions. With a raised CA15-3 and strong oestrogen receptor positivity on immunohistochemistry on a trephine bone marrow biopsy, a diagnosis of metastatic lobular breast cancer was made...
2014: BMJ Case Reports
Tobias A Mattei, Ehud Mendel, Eric C Bourekas
BACKGROUND CONTEXT: Denosumab (XGeva) is a receptor activator of nuclear factor-κB ligand (RANKL)-antibody that was approved by the Food and Drug Administration (FDA) in 2010 for the prevention of skeletal fractures in patients with bone metastases from solid tumors. Although there is a widespread use of such drug in patients under risk of pathological fractures, the compatibility of denosumab therapy with percutaneous vertebroplasty (an interventional procedure commonly used for pain control in such population) has not yet been established...
June 1, 2014: Spine Journal: Official Journal of the North American Spine Society
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