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https://www.readbyqxmd.com/read/29290793/epigenomic-characterization-of-a-p53-regulated-3p22-2-tumor-suppressor-that-inhibits-stat3-phosphorylation-via-protein-docking-and-is-frequently-methylated-in-esophageal-and-other-carcinomas
#1
Lili Li, Juan Xu, Guohua Qiu, Jianming Ying, Zhenfang Du, Tingxiu Xiang, Kai Yau Wong, Gopesh Srivastava, Xiao-Feng Zhu, Tony S Mok, Anthony Tc Chan, Francis Kl Chan, Richard F Ambinder, Qian Tao
Rationale: Oncogenic STAT3 signaling activation and 3p22-21.3 locus alteration are common in multiple tumors, especially carcinomas of the nasopharynx, esophagus and lung. Whether these two events are linked remains unclear. Our CpG methylome analysis identified a 3p22.2 gene, DLEC1, as a methylated target in esophageal squamous cell (ESCC), nasopharyngeal (NPC) and lung carcinomas. Thus, we further characterized its epigenetic abnormalities and functions. Methods: CpG methylomes were established by methylated DNA immunoprecipitation...
2018: Theranostics
https://www.readbyqxmd.com/read/29237490/linc-ror-promotes-esophageal-squamous-cell-carcinoma-progression-through-the-derepression-of-sox9
#2
Lianghai Wang, Xiaodan Yu, Zhiyu Zhang, Lijuan Pang, Jiang Xu, Jinfang Jiang, Weihua Liang, Yuhang Chai, Jun Hou, Feng Li
BACKGROUND: Novel therapies tailored to the molecular composition of esophageal squamous cell carcinoma (ESCC) are needed to improve patient survival. We investigated the regulatory network of long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) and sex-determining region Y-box 9 (SOX9), and their therapeutic relevance in ESCC. METHODS: Linc-ROR and SOX9 expression were examined in ESCC specimens, cell lines, and cultured tumorspheres. We investigated the effects of linc-ROR on SOX9 expression and malignant phenotypes by CCK8, colony formation, Transwell, and sphere-forming assay...
December 13, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29208461/simvastatin-inhibits-the-development-of-radioresistant-esophageal-cancer-cells-by-increasing-the-radiosensitivity-and-reversing-emt-process-via-the-pten-pi3k-akt-pathway
#3
Yingying Jin, Kun Xu, Qingjuan Chen, Baofeng Wang, Jiyuan Pan, Shan Huang, Yang Wei, Hongbing Ma
Acquired radioresistance compromises the efficacy of radiotherapy for carcinomas including esophageal cancer (EC), thus resulting in recurrence and poor survival. Recent research corroborated radiosensitive function of simvastatin in stem-like breast cancer cells. However, its role in EC radioresistance remains poorly elucidated. Here, we developed a radioresistant EC cell line Ec9706-R with higher resistance to irradiation relative to control Ec9706 cells. Intriguingly, Ec9706-R cells exhibited epithelial-mesenchymal transition (EMT) characteristics with high invasion and migration ability...
December 2, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29182640/changes-in-the-interstitial-cells-of-cajal-and-neuronal-nitric-oxide-synthase-positive-neuronal-cells-with-aging-in-the-esophagus-of-f344-rats
#4
Hee Jin Kim, Nayoung Kim, Yong Sung Kim, Ryoung Hee Nam, Sun Min Lee, Ji Hyun Park, Daeun Choi, Young-Jae Hwang, Jongchan Lee, Hye Seung Lee, Min-Seob Kim, Moon Young Lee, Dong Ho Lee
The aging-associated cellular and molecular changes in esophagus have not been established, yet. Thus we evaluated histological structure, interstitial cells of Cajal (ICCs), neuronal nitric oxide synthase (nNOS)-positive cells, and contractility in the esophagus of Fischer 344 rat at different ages (6-, 31-, 74-weeks, and 2-years). The lamina propria thickness and endomysial area were calculated. The immunoreactivity of c-Kit, nNOS and protein gene product (PGP) 9.5 was counted after immunohistochemistry. Expression of c-Kit, stem cell factor (SCF), nNOS and PGP 9...
2017: PloS One
https://www.readbyqxmd.com/read/29181273/optimizing-peptide-epitope-based-autoantibody-detection-in-cancer-patients
#5
Maize Wang, Shirley H Lomeli, Wilbur A Franklin, Sarah Lee, Allan J Pantuck, Gang Zeng
Autoantibody (autoAb) response is an important arm of endogenously arising anti-tumor immune responses, and has received new attention as a cancer biomarker with the recent success of immune check-point inhibitor therapy. Our laboratory has been focusing on measuring autoAb against B-cell epitopes in order to bypass the necessity to purify a panel of recombinant proteins. In order to optimize peptide-based autoAb measurement and to increase sensitivities to cover more patients, we developed a new approach of using mixed peptides to conjugate on the same microsphere and compared its results with the use of a dominant peptide epitope using Luminex microbead-based multiplex assays...
2017: American Journal of Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29181066/stem-cell-factor-in-the-serum-of-patients-with-esophageal-cancer-in-relation-to-its-histological-types
#6
Marta Łukaszewicz-Zając, Barbara Mroczko, Mirosław Kozłowski, Maciej Szmitkowski
Introduction: Hematopoietic growth factors (HGFs), such as stem cell factor (SCF), may stimulate proliferation and differentiation of hematopoietic progenitor cells. Stem cell factor is also able to affect the growth of malignant tumors, including esophageal cancer (EC). The prognosis of EC patients' survival is still unfavorable. Thus, novel biomarkers are necessary to improve the diagnosis and prognosis of EC patients. The aim of this study was to determine the serum SCF concentrations in EC patients in relation to its histological types and compare these levels with the classical tumor marker - carcinoembryonic antigen (CEA)...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29167315/a-novel-yap1-inhibitor-targets-cscs-enriched-radiation-resistant-cells-and-exerts-strong-antitumor-activity-in-esophageal-adenocarcinoma
#7
Shumei Song, Min Xie, Ailing W Scott, Jiankang Jin, Lang Ma, Xiaochuan Dong, Heath D Skinner, Randy L Johnson, Sheng Ding, Jaffer A Ajani
Mounting evidence suggests that the Hippo co-activator Yes-associated protein 1 (YAP1) is a major mediator of cancer stem cell (CSC) properties, tumor progression, and therapy resistance as well as often a terminal node of many oncogenic pathways. Thus, targeting YAP1 may be a novel therapeutic strategy for many types of tumors with high YAP1 expression, including esophageal adenocarcinoma (EAC). However, effective YAP1 inhibitors are currently lacking. Here, we identify a small molecule (CA3) that not only has remarkable inhibitory activity on YAP1/Tead transcriptional activity but also demonstrates strong inhibitory effects on EAC cell growth especially on YAP1 high expressing EAC cells both in vitro and in vivo...
November 22, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29137934/the-notch-pathway-is-activated-in-neoplastic-progression-in-esophageal-squamous-cell-carcinoma
#8
Daniel Lubin, Rosemarie Mick, Stuti G Shroff, Kristen Stashek, Emma Furth
The Notch signaling pathway is integral to normal human development and homeostasis and has a deterministic function on cell differentiation. Recent studies suggest aberrant Notch signaling may contribute to neoplastic progression by an increase in stem cell survival, chemoresistance, and the promotion of epithelial to mesenchymal transition. The goals of our study were to determine, utilizing quantitative technologies, the expression of activated Notch 1 in esophageal squamous cell carcinoma (SCC) and to determine the relationship between Notch 1 expression and various clinicopathologic parameters...
November 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29059170/spsb3-targets-snail-for-degradation-in-gsk-3%C3%AE-phosphorylation-dependent-manner-and-regulates-metastasis
#9
Y Liu, H Zhou, R Zhu, F Ding, Y Li, X Cao, Z Liu
Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcription factor SNAIL is one of the most important initiators of EMT. Therefore, it is of great significance to understand the regulating mechanism of SNAIL. In this study, we carried out a luciferase-based genome-wide screening using small interfering RNA library against ~200 of E3 ligases and ubiquitin-related genes and identified SOCS box protein SPSB3 as a novel E3 ligase component that targets SNAIL into polyubiquitination and degradation in response to GSK-3β phosphorylation of SNAIL...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29059160/il6-derived-from-cancer-associated-fibroblasts-promotes-chemoresistance-via-cxcr7-in-esophageal-squamous-cell-carcinoma
#10
Y Qiao, C Zhang, A Li, D Wang, Z Luo, Y Ping, B Zhou, S Liu, H Li, D Yue, Z Zhang, X Chen, Z Shen, J Lian, Y Li, S Wang, F Li, L Huang, L Wang, B Zhang, J Yu, Z Qin, Y Zhang
Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived mainly from cancer-associated fibroblasts played the most important role in chemoresistance by upregulating C-X-C motif chemokine receptor 7 (CXCR7) expression through signal transducer and activator of transcription 3/nuclear factor-κB pathway...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/28985034/esophageal-adenocarcinoma-microenvironment-peritumoral-adipose-tissue-effects-associated-with-chemoresistance
#11
Amedeo Carraro, Elisabetta Trevellin, Matteo Fassan, Andromachi Kotsafti, Francesca Lunardi, Andrea Porzionato, Luigi Dall'Olmo, Matteo Cagol, Rita Alfieri, Veronica Macchi, Umberto Tedeschi, Fiorella Calabrese, Massimo Rugge, Carlo Castoro, Roberto Vettor, Marco Scarpa
Peritumoral microenvironment affects cancer development and chemoresistance, and visceral adipose tissue may play a critical role. We aimed to identify depot-specific adipose characteristics associated with carcinogenesis and resistance to neoadjuvant therapy, in esophageal adenocarcinoma (EAC). We analysed: 1) the peritumoral adipose tissue of rats, following the induction of esophageal carcinogenesis; 2) the peritumoral and distal (omental) adipose tissue of patients affected by EAC; 3) adipose-derived stem cells (ADSCs) isolated from healthy patients and treated with conditioned medium (CM), collected from tumoral and adipose tissue of patients with EAC...
October 6, 2017: Cancer Science
https://www.readbyqxmd.com/read/28962198/analysis-of-risk-factors-for-post-operative-complications-and-prognostic-predictors-of-disease-recurrence-following-definitive-treatment-of-patients-with-esophageal-cancer-from-two-medical-centers-in-northwest-china
#12
Jichang Wang, Boxiang Zhang, Jinying Meng, Guodong Xiao, Xiang Li, Gang Li, Sida Qin, Ning Du, Jia Zhang, Jing Zhang, Chongwen Xu, Shou-Ching Tang, Rui Liang, Hong Ren, Xin Sun
Evaluating the clinicopathological features of patients receiving definitive treatment for esophageal cancer may facilitate the identification of patterns and factors associated with post-operative complications, and enable the development of a surveillance strategy for surviving patients at a higher risk of disease recurrence. In the present study, clinical data from 579 patients with esophageal cancer that underwent radical resection of esophagus were collected. These patients were admitted to two medical centers in Northwest China, and information regarding the presence or absence of basic chronic diseases and post-operative results were retrospectively analyzed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28950176/effective-tumor-immunity-to-melanoma-mediated-by-b16f10-cancer-stem-cell-vaccine
#13
Fengshu Zhao, Rong Zhang, Jing Wang, Di Wu, Meng Pan, Miao Li, Mei Guo, Jun Dou
Although tumor vaccines have been considered a promising immunotherapy approach, therapeutic tumor vaccines are mostly disappointing in the clinic due to vaccine weak immunogenicity. Cancer stem cells (CSCs) may broaden the antigenic breadth and effectively induce the immune responses against autologous cancer cells. Here we report on the development of the B16F10 CD133(+)CD44(+)CSCs (B16F10 CSCs) vaccine to induce tumor immunity to melanoma in mice. Efficacy of against melanoma was evaluated by analysis of tumor growth and mouse survival...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28930282/esophageal-cancer-genomic-and-molecular-characterization-stem-cell-compartment-and-clonal-evolution
#14
REVIEW
Ugo Testa, Germana Castelli, Elvira Pelosi
Esophageal cancer (EC) is the eighth most common cancer and is the sixth leading cause of death worldwide. The incidence of histologic subtypes of EC, esophageal adenocarcinoma (EAC) and esophageal squamous carcinoma (ESCC), display considerable geographic variation. EAC arises from metaplastic Barrett's esophagus (BE) in the context of chronic inflammation secondary to exposure to acid and bile. The main risk factors for developing ESCC are cigarette smoking and alcohol consumption. The main somatic genetic abnormalities showed a different genetic landscape in EAC compared to ESCC...
September 14, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28927233/fibroblast-growth-factor-2-mediated-fgfr-erk-signaling-supports-maintenance-of-cancer-stem-like-cells-in-esophageal-squamous-cell-carcinoma
#15
Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, Shunsuke Ohnishi, Yoshito Komatsu, Fumiyuki Sato, Masato Nakai, Takuya Sho, Kenichi Morikawa, Koji Ogawa, Tomoe Shimazaki, Megumi Kimura, Ayaka Asano, Yoshiyuki Fujimoto, Shinya Ohashi, Shingo Kagawa, Hideaki Kinugasa, Seiji Naganuma, Kelly A Whelan, Hiroshi Nakagawa, Koji Nakagawa, Hiroshi Takeda, Naoya Sakamoto
In esophageal squamous cell carcinoma (ESCC), a subset of cells defined by high expression of CD44 and low expression of CD24 has been reported to possess characteristics of cancer stem-like cells (CSCs). Novel therapies directly targeting CSCs have the potential to improve prognosis of ESCC patients. Although fibroblast growth factor-2 (FGF-2) expression correlates with recurrence and poor survival in ESCC patients, the role of FGF-2 in regulation of ESCC CSCs has yet to be elucidated. We report that FGF-2 is significantly upregulated in CSCs and significantly increases CSC content in ESCC cell lines by inducing epithelial-mesenchymal transition (EMT)...
October 26, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28914471/wash-overexpression-enhances-cancer-stem-cell-properties-and-correlates-with-poor-prognosis-of-esophageal-carcinoma
#16
Lan Huang, Jingyao Lian, Xinfeng Chen, Guohui Qin, Yujia Zheng, Yi Zhang
There is increasing evidence that cytoskeleton remodeling is involved in cancer progression. Wiskott-Aldrich syndrome Protein (WASP) family represents a key regulator of actin cytoskeleton remodeling. However, the underlying mechanism of WASP family in cancer progression remains elusive. Here, we studied the role of WASP and SCAR Homolog (WASH), a recently identified WASP family member, in human esophageal squamous cell carcinoma (ESCC). Using three human ESCC cell lines, we found that WASH expression was significantly elevated in cancer stem-like cells enriched by sphere formation assay...
September 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/28902370/nano-let%C3%A2-7b-sensitization-of-eliminating-esophageal-cancer-stem%C3%A2-like-cells-is-dependent-on-blockade-of-wnt-activation-of-symmetric-division
#17
Yamei Pang, Jian Liu, Xiang Li, Yiwen Zhang, Boxiang Zhang, Jing Zhang, Ning Du, Chongwen Xu, Rui Liang, Hong Ren, Shou-Ching Tang, Xin Sun
The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy would improve the therapeutic efficacy. After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28888039/role-of-aldh1-in-the-prognosis-of-esophageal-cancer-and-its-relationship-with-tumor-microenvironment
#18
Miao-Fen Chen, Ping-Tsung Chen, Ming-Shian Lu, Wen-Cheng Chen
Aldehyde dehydrogenase 1 (ALDH1) is associated with tumorigenesis, and significantly increased in cancer stem-like cells. In the present study, the role of ALDH1 in esophageal squamous cell carcinoma (ESCC) was investigated. We retrospectively analyzed the clinical outcomes of 148 ESCC and examined its correlation with ALDH1 levels. Furthermore, we preformed cellular and animal experiments to investigate the role of ALDH1 in tumor progression and microenvironment. Our data revealed that ALDH1 staining was positively linked to a higher clinical stage, higher loco-regional failure rate and shorter survival time...
September 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28819854/flow-cytometric-detection-of-circulating-tumor-cells-using-a-candidate-stem-cell-marker-p75-neurotrophin-receptor-p75ntr
#19
Tomoyuki Okumura, Tetsuji Yamaguchi, Toru Watanabe, Takuya Nagata, Yutaka Shimada
The most widely studied detection for circulating tumor cells (CTCs) in peripheral blood of cancer patients has been based on immunomagnetic enrichment using antibodies against epithelial cell adhesion molecule (EpCAM), which is overexpressed in epithelial cells. A neurotrophin receptor p75 (p75NTR) is expressed in a candidate stem cell fraction in esophageal squamous cell carcinoma (ESCC), which shows significantly higher colony formation, enhanced tumor formation in mice, along with strong expression of epithelial mesenchymal transition-related genes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28782137/interkinetic-nuclear-migration-in-the-tracheal-and-esophageal-epithelia-of-the-mouse-embryo-possible-implications-for-tracheo-esophageal-anomalies
#20
Ryo Kaneda, Yuko Saeki, Dereje Getachew, Akihiro Matsumoto, Motohide Furuya, Noriko Ogawa, Tomoyuki Motoya, Ashiq Mahmood Rafiq, Esrat Jahan, Jun Udagawa, Ryuju Hashimoto, Hiroki Otani
Interkinetic nuclear migration (INM) is a cell polarity-based phenomenon in which progenitor cell nuclei migrate along the apico-basal axis of the pseudostratified epithelium in synchrony with the cell cycle. INM is suggested to be at least partially cytoskeleton-dependent and to regulate not only the proliferation/differentiation of stem/progenitor cells but also the localized/overall size and shape of organs/tissues. INM occurs in all three of the germ-layer derived epithelia, including the endoderm-derived gut...
August 6, 2017: Congenital Anomalies
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