keyword
MENU ▼
Read by QxMD icon Read
search

Stem cell esophageal

keyword
https://www.readbyqxmd.com/read/29137934/the-notch-pathway-is-activated-in-neoplastic-progression-in-esophageal-squamous-cell-carcinoma
#1
Daniel Lubin, Rosemarie Mick, Stuti G Shroff, Kristen Stashek, Emma Furth
The Notch signaling pathway is integral to normal human development and homeostasis and has a deterministic function on cell differentiation. Recent studies suggest aberrant Notch signaling may contribute to neoplastic progression by an increase in stem cell survival, chemoresistance, and the promotion of epithelial to mesenchymal transition. The goals of our study were to determine, utilizing quantitative technologies, the expression of activated Notch 1 in esophageal squamous cell carcinoma (SCC) and to determine the relationship between Notch 1 expression and various clinicopathologic parameters...
November 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29059170/spsb3-targets-snail-for-degradation-in-gsk-3%C3%AE-phosphorylation-dependent-manner-and-regulates-metastasis
#2
Y Liu, H Zhou, R Zhu, F Ding, Y Li, X Cao, Z Liu
Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcription factor SNAIL is one of the most important initiators of EMT. Therefore, it is of great significance to understand the regulating mechanism of SNAIL. In this study, we carried out a luciferase-based genome-wide screening using small interfering RNA library against ~200 of E3 ligases and ubiquitin-related genes and identified SOCS box protein SPSB3 as a novel E3 ligase component that targets SNAIL into polyubiquitination and degradation in response to GSK-3β phosphorylation of SNAIL...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29059160/il6-derived-from-cancer-associated-fibroblasts-promotes-chemoresistance-via-cxcr7-in-esophageal-squamous-cell-carcinoma
#3
Y Qiao, C Zhang, A Li, D Wang, Z Luo, Y Ping, B Zhou, S Liu, H Li, D Yue, Z Zhang, X Chen, Z Shen, J Lian, Y Li, S Wang, F Li, L Huang, L Wang, B Zhang, J Yu, Z Qin, Y Zhang
Various factors and cellular components in the tumor microenvironment are key drivers associated with drug resistance in many cancers. Here, we analyzed the factors and molecular mechanisms involved in chemoresistance in patients with esophageal squamous cell carcinoma (ESCC). We found that interleukin 6 (IL6) derived mainly from cancer-associated fibroblasts played the most important role in chemoresistance by upregulating C-X-C motif chemokine receptor 7 (CXCR7) expression through signal transducer and activator of transcription 3/nuclear factor-κB pathway...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/28985034/esophageal-adenocarcinoma-microenvironment-peritumoral-adipose-tissue-effects-associated-with-chemoresistance
#4
Amedeo Carraro, Elisabetta Trevellin, Matteo Fassan, Andromachi Kotsafti, Francesca Lunardi, Andrea Porzionato, Luigi Dall'Olmo, Matteo Cagol, Rita Alfieri, Veronica Macchi, Umberto Tedeschi, Fiorella Calabrese, Massimo Rugge, Carlo Castoro, Roberto Vettor, Marco Scarpa
Peritumoral microenvironment affects cancer development and chemoresistance, and visceral adipose tissue may play a critical role. We aimed to identify depot-specific adipose characteristics associated with carcinogenesis and resistance to neoadjuvant therapy, in esophageal adenocarcinoma (EAC). We analysed: 1) the peritumoral adipose tissue of rats, following the induction of esophageal carcinogenesis; 2) the peritumoral and distal (omental) adipose tissue of patients affected by EAC; 3) adipose-derived stem cells (ADSCs) isolated from healthy patients and treated with conditioned medium (CM), collected from tumoral and adipose tissue of patients with EAC...
October 6, 2017: Cancer Science
https://www.readbyqxmd.com/read/28962198/analysis-of-risk-factors-for-post-operative-complications-and-prognostic-predictors-of-disease-recurrence-following-definitive-treatment-of-patients-with-esophageal-cancer-from-two-medical-centers-in-northwest-china
#5
Jichang Wang, Boxiang Zhang, Jinying Meng, Guodong Xiao, Xiang Li, Gang Li, Sida Qin, Ning Du, Jia Zhang, Jing Zhang, Chongwen Xu, Shou-Ching Tang, Rui Liang, Hong Ren, Xin Sun
Evaluating the clinicopathological features of patients receiving definitive treatment for esophageal cancer may facilitate the identification of patterns and factors associated with post-operative complications, and enable the development of a surveillance strategy for surviving patients at a higher risk of disease recurrence. In the present study, clinical data from 579 patients with esophageal cancer that underwent radical resection of esophagus were collected. These patients were admitted to two medical centers in Northwest China, and information regarding the presence or absence of basic chronic diseases and post-operative results were retrospectively analyzed...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28950176/effective-tumor-immunity-to-melanoma-mediated-by-b16f10-cancer-stem-cell-vaccine
#6
Fengshu Zhao, Rong Zhang, Jing Wang, Di Wu, Meng Pan, Miao Li, Mei Guo, Jun Dou
Although tumor vaccines have been considered a promising immunotherapy approach, therapeutic tumor vaccines are mostly disappointing in the clinic due to vaccine weak immunogenicity. Cancer stem cells (CSCs) may broaden the antigenic breadth and effectively induce the immune responses against autologous cancer cells. Here we report on the development of the B16F10 CD133(+)CD44(+)CSCs (B16F10 CSCs) vaccine to induce tumor immunity to melanoma in mice. Efficacy of against melanoma was evaluated by analysis of tumor growth and mouse survival...
November 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28930282/esophageal-cancer-genomic-and-molecular-characterization-stem-cell-compartment-and-clonal-evolution
#7
REVIEW
Ugo Testa, Germana Castelli, Elvira Pelosi
Esophageal cancer (EC) is the eighth most common cancer and is the sixth leading cause of death worldwide. The incidence of histologic subtypes of EC, esophageal adenocarcinoma (EAC) and esophageal squamous carcinoma (ESCC), display considerable geographic variation. EAC arises from metaplastic Barrett's esophagus (BE) in the context of chronic inflammation secondary to exposure to acid and bile. The main risk factors for developing ESCC are cigarette smoking and alcohol consumption. The main somatic genetic abnormalities showed a different genetic landscape in EAC compared to ESCC...
September 14, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28927233/fibroblast-growth-factor-2-mediated-fgfr-erk-signaling-supports-maintenance-of-cancer-stem-like-cells-in-esophageal-squamous-cell-carcinoma
#8
Osamu Maehara, Goki Suda, Mitsuteru Natsuizaka, Shunsuke Ohnishi, Yoshito Komatsu, Fumiyuki Sato, Masato Nakai, Takuya Sho, Kenichi Morikawa, Koji Ogawa, Tomoe Shimazaki, Megumi Kimura, Ayaka Asano, Yoshiyuki Fujimoto, Shinya Ohashi, Shingo Kagawa, Hideaki Kinugasa, Seiji Naganuma, Kelly A Whelan, Hiroshi Nakagawa, Koji Nakagawa, Hiroshi Takeda, Naoya Sakamoto
In esophageal squamous cell carcinoma (ESCC), a subset of cells defined by high expression of CD44 and low expression of CD24 has been reported to possess characteristics of cancer stem-like cells (CSCs). Novel therapies directly targeting CSCs have the potential to improve prognosis of ESCC patients. Although fibroblast growth factor-2 (FGF-2) expression correlates with recurrence and poor survival in ESCC patients, the role of FGF-2 in regulation of ESCC CSCs has yet to be elucidated. We report that FGF-2 is significantly upregulated in CSCs and significantly increases CSC content in ESCC cell lines by inducing epithelial-mesenchymal transition (EMT)...
October 26, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28914471/wash-overexpression-enhances-cancer-stem-cell-properties-and-correlates-with-poor-prognosis-of-esophageal-carcinoma
#9
Lan Huang, Jingyao Lian, Xinfeng Chen, Guohui Qin, Yujia Zheng, Yi Zhang
There is increasing evidence that cytoskeleton remodeling is involved in cancer progression. Wiskott-Aldrich syndrome Protein (WASP) family represents a key regulator of actin cytoskeleton remodeling. However, the underlying mechanism of WASP family in cancer progression remains elusive. Here, we studied the role of WASP and SCAR Homolog (WASH), a recently identified WASP family member, in human esophageal squamous cell carcinoma (ESCC). Using three human ESCC cell lines, we found that WASH expression was significantly elevated in cancer stem-like cells enriched by sphere formation assay...
September 15, 2017: Cancer Science
https://www.readbyqxmd.com/read/28902370/nano-let%C3%A2-7b-sensitization-of-eliminating-esophageal-cancer-stem%C3%A2-like-cells-is-dependent-on-blockade-of-wnt-activation-of-symmetric-division
#10
Yamei Pang, Jian Liu, Xiang Li, Yiwen Zhang, Boxiang Zhang, Jing Zhang, Ning Du, Chongwen Xu, Rui Liang, Hong Ren, Shou-Ching Tang, Xin Sun
The poor therapy response and poor prognosis of esophageal cancer has made it one of the most malignant carcinoma, and the complicated multidisciplinary treatment failed to achieve a long-term disease-free survival. To diagnose esophageal cancer at an earlier stage, and to improve the effect of anticancer therapy would improve the therapeutic efficacy. After retrospective analysis of the cancer samples of patients who received esophagectomy, we found the relevance between ratio of either ALDH1 or CD133-positive cancer stem cells and 2-year recurrence...
October 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28888039/role-of-aldh1-in-the-prognosis-of-esophageal-cancer-and-its-relationship-with-tumor-microenvironment
#11
Miao-Fen Chen, Ping-Tsung Chen, Ming-Shian Lu, Wen-Cheng Chen
Aldehyde dehydrogenase 1 (ALDH1) is associated with tumorigenesis, and significantly increased in cancer stem-like cells. In the present study, the role of ALDH1 in esophageal squamous cell carcinoma (ESCC) was investigated. We retrospectively analyzed the clinical outcomes of 148 ESCC and examined its correlation with ALDH1 levels. Furthermore, we preformed cellular and animal experiments to investigate the role of ALDH1 in tumor progression and microenvironment. Our data revealed that ALDH1 staining was positively linked to a higher clinical stage, higher loco-regional failure rate and shorter survival time...
September 9, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28819854/flow-cytometric-detection-of-circulating-tumor-cells-using-a-candidate-stem-cell-marker-p75-neurotrophin-receptor-p75ntr
#12
Tomoyuki Okumura, Tetsuji Yamaguchi, Toru Watanabe, Takuya Nagata, Yutaka Shimada
The most widely studied detection for circulating tumor cells (CTCs) in peripheral blood of cancer patients has been based on immunomagnetic enrichment using antibodies against epithelial cell adhesion molecule (EpCAM), which is overexpressed in epithelial cells. A neurotrophin receptor p75 (p75NTR) is expressed in a candidate stem cell fraction in esophageal squamous cell carcinoma (ESCC), which shows significantly higher colony formation, enhanced tumor formation in mice, along with strong expression of epithelial mesenchymal transition-related genes...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28782137/interkinetic-nuclear-migration-in-the-tracheal-and-esophageal-epithelia-of-the-mouse-embryo-possible-implications-for-tracheo-esophageal-anomalies
#13
Ryo Kaneda, Yuko Saeki, Dereje Getachew, Akihiro Matsumoto, Motohide Furuya, Noriko Ogawa, Tomoyuki Motoya, Ashiq Mahmood Rafiq, Esrat Jahan, Jun Udagawa, Ryuju Hashimoto, Hiroki Otani
Interkinetic nuclear migration (INM) is a cell polarity-based phenomenon in which progenitor cell nuclei migrate along the apico-basal axis of the pseudostratified epithelium in synchrony with the cell cycle. INM is suggested to be at least partially cytoskeleton-dependent and to regulate not only the proliferation/differentiation of stem/progenitor cells but also the localized/overall size and shape of organs/tissues. INM occurs in all three of the germ-layer derived epithelia, including the endoderm-derived gut...
August 6, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28713964/musashi1-a-potential-prognostic-marker-in-esophageal-squamous-cell-carcinoma
#14
Guohui Qin, Jingyao Lian, Dongli Yue, Xinfeng Chen, Shufeng Nan, Yu Qi, Bing Li, Guanghui Cui, Xiangnan Li, Song Zhao, Yi Zhang
Esophageal cancer ranks as the sixth leading cause of cancer-related deaths worldwide. Cancer stemness is mainly considered to be the key factor for cancer recurrence particularly in esophageal cancer. It is important to identify cancer stem cell markers as targets in future therapies. The present study aimed to investigate the expression of putative cancer stem cell-related marker musashi1 (Msi1) and assess the correlation with clinicopathologcal status of esophageal squamous cell carcinoma (ESCC) cases. We then clarified the role of Msi1 in esophageal cancer cells during proliferation, apoptosis, sphere formation and migration...
September 2017: Oncology Reports
https://www.readbyqxmd.com/read/28711168/surgical-treatment-of-intestinal-complications-of-graft-versus-host-disease-in-the-pediatric-population-case-series-and-review-of-literature
#15
REVIEW
Camille A Gutierrez, Mehul V Raval, Hannah R Vester, Sonali Chaudhury, Daniel von Allmen, David H Rothstein
BACKGROUND/PURPOSE: Intestinal complications of acute graft-versus-host disease (aGVHD) include hemorrhage and perforation in the short-term, and stricture with bowel obstruction in the long-term. As medical management of severe aGVHD has improved, more patients are surviving even advanced stages of intestinal aGVHD. This review summarizes the available pediatric literature on surgical treatment of complications of intestinal GVHD. METHODS: A systematic review was performed using PubMed, Cochrane, Embase, and Scopus databases...
November 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28707966/targeted-molecular-ablation-of-cancer-stem-cells-for-curing-gastrointestinal-cancers
#16
Yong Seok Kim, Ho Jae Lee, Jong-Min Park, Young-Min Han, Napapan Kangwan, Ji Young Oh, Dong Yoon Lee, Ki Baik Hahm
Abundance of the ATPase-binding cassette (ABC) transporters and deranged self-renewal pathways characterize the presence of cancer stem cells (CSCs) in gastrointestinal cancers (GI cancers), which play crucial roles in tumorigenesis, chemotherapy resistance, tumor recurrence, and cancer metastasis. Therefore, in order to ensure high cure rates, chemoquiescence, CSCs should be ablated. Recent advances in either understanding CSCs or biomarker identification enable scientists to develop techniques for ablating CSCs and clinicians to provide cancer cure, especially in GI cancers characterized by inflammation-driven carcinogenesis...
November 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28681114/predicting-the-correlation-of-ezh2-and-cancer-stem-cell-markers-in-esophageal-squamous-cell-carcinoma
#17
GholamReza Karami Madani, Abolfazl Rad, Mehdi Molavi, Sima Ardalan Khales, Mohammad Reza Abbaszadegan, Mohammad Mahdi Forghanifard
BACKGROUND: Enhancer of zeste homolog 2 (EZH2), a stemness factor, plays roles in regulation of cell differentiation and embryonic development as well as cancer progression. Deregulation of EZH2 in cancers is correlated with tumor cell invasiveness, metastasis, and the patients' poor outcome. However, the mechanistic role of EZH2 in cancer is ambiguous. In this study, we aimed to inhibit the expression of EZH2 in a cancer cell line, and evaluate consequence changes in gene expression pattern...
July 6, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28665192/adipose-tissue-derived-stem-cell-sheet-application-for-tissue-healing-in-vivo-a-systematic-review
#18
Panithi Sukho, Abigael Cohen, Jan Willem Hesselink, Jolle Kirpensteijn, Femke Verseijden, Yvonne M Bastiaansen-Jenniskens
Adipose tissue-derived stem cells (ASCs) are known to be tissue-healing promoters due to their cellular plasticity and secretion of paracrine factors. Cultured ASC sheets provide a novel method of ASC application and can retain ASCs at the targeted tissue. The purpose of this systematic review is to evaluate preclinical studies using ASC sheet transplantation therapy for promoting tissue healing. First, we searched databases to identify studies of ASC sheet therapy in different experimental animal models, and then determined the quality score of studies using SYRCLE's risk bias tool...
August 4, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28656652/impressive-tissue-regeneration-of-severe-oral-mucositis-post-stem-cell-transplantation-using-cord-blood-platelet-gel
#19
Andrea Piccin, Paolo Rebulla, Simonetta Pupella, Mario Tagnin, Giuseppe Marano, Angela Maria Di Pierro, Michele Santodirocco, Lazzaro Di Mauro, Lisa Beqiri, Michael Kob, Marco Primerano, Marco Casini, Atto Billio, Klaus Eisendle, Fabrizio Fontanella
BACKGROUND: Platelet gel from cord blood (CBPG) is a recently developed blood component for topical use. We report a case of life-threatening mucositis after high-dose chemotherapy with fotemustine and cytarabine that was successfully treated with CBPG. CASE REPORT: A patient with non-Hodgkin lymphoma who was undergoing autologous hematopoietic stem cell transplantation developed severe oral and esophageal mucositis with severe bacterial sepsis and cytomegalovirus infection, causing prolonged neutropenia...
September 2017: Transfusion
https://www.readbyqxmd.com/read/28633632/antagonizing-mir-455-3p-inhibits-chemoresistance-and-aggressiveness-in-esophageal-squamous-cell-carcinoma
#20
Aibin Liu, Jinrong Zhu, Geyan Wu, Lixue Cao, Zhanyao Tan, Shuxia Zhang, Lili Jiang, Jueheng Wu, Mengfeng Li, Libing Song, Jun Li
BACKGROUND: The plasticity of cancer stem cells (CSCs)/tumor-initiating cells (T-ICs) suggests that multiple CSC/T-IC subpopulations exist within a tumor and that multiple oncogenic pathways collaborate to maintain the CSC/T-IC state. Here, we aimed to identify potential therapeutic targets that concomitantly regulate multiple T-IC subpopulations and CSC/T-IC-associated pathways. METHODS: A chemoresistant patient-derived xenograft (PDX) model of human esophageal squamous cell carcinoma (ESCC) was employed to identify microRNAs that contribute to ESCC aggressiveness...
June 21, 2017: Molecular Cancer
keyword
keyword
62955
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"