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Aspergillus fumigatus

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https://www.readbyqxmd.com/read/29456195/mast-cell-tryptase-changes-with-aspergillus-fumigatus-host-crosstalk-in-cystic-fibrosis-patients
#1
Carine Gomez, Ania Carsin, Marion Gouitaa, Martine Reynaud-Gaubert, Jean-Christophe Dubus, Jean-Louis Mège, Stéphane Ranque, Joana Vitte
Pulmonary and systemic antifungal immunity influences quality of life and survival of people with cystic fibrosis. Aspergillus fumigatus (Af) induces specific IgG and IgE. Mast cells respond to IgE, IgG and direct interactions with Af. Mast cells are the source of the protease tryptase. We aimed at evaluating serum baseline tryptase as a potential biomarker of the Af-host interaction in cystic fibrosis patients. Serum baseline tryptase, IgE and IgG directed to Af extract and Af molecular allergens were measured in 76 cystic fibrosis patients...
February 15, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29452851/elastin-increases-biofilm-and-extracellular-matrix-production-of-aspergillus-fumigatus
#2
Ildnay de Souza Lima Brandão, Heloiza Maria da Silva Oliveira-Moraes, Cristina Maria de Souza Motta, Neiva Tinti de Oliveira, Oliane Maria Correia Magalhães
Aspergillus fumigatus is an opportunistic saprobe fungus that accounts for 90% of cases of pulmonary aspergillosis in immunosuppressed patients and is known for its angiotropism. When it reaches the respiratory tract, A. fumigatus interacts with structural components and blood vessels of the lungs, such as elastin. To understand the effect of this structural component, we examined the effect of elastin on the production and development of the biofilm of A. fumigatus. In RPMI containing 10mg/mL of elastin, a significant increase (absorbance p<0...
February 13, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29452846/differential-role-of-gpab-and-sida-gene-expressions-in-relation-to-virulence-in-aspergillus-species-from-patients-with-invasive-aspergillosis
#3
Nayereh Ghods, Mehraban Falahati, Maryam Roudbary, Shirin Farahyar, Masoud Shamaei, Mahin Pourabdollah, Farhad Seif
The virulence genes in invasive aspergillosis (IA) have not been analyzed adequately. The present study was designed to evaluate the expression of gpaB and sidA genes, which are important virulence genes in Aspergillus spp. from bronchoalveolar lavage (BAL) samples. Direct examination and culture on Czapek Agar and Sabouraud Dextrose Agar media were performed for 600 BAL specimens isolated from patients with possible aspergillosis. A Galactomannan ELISA assay was also carried out. The expression levels of the gpaB and sidA genes in isolates were analyzed using quantitative real-time PCR (qRT-PCR)...
February 3, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29449177/cloning-and-expression-of-an-endoglucanase-gene-from-the-thermotolerant-fungus-aspergillus-fumigatus-dbinu-1-in-kluyveromyces-lactis
#4
Budsayachat Rungrattanakasin, Siripong Premjet, Sudarat Thanonkeo, Preekamol Klanrit, Pornthap Thanonkeo
An intronless endoglucanase from thermotolerant Aspergillus fumigatus DBINU-1 was cloned, characterized and expressed in the yeast Kluyveromyces lactis. The full-length open reading frame of the endoglucanase gene from A. fumigatus DBiNU-1, designated Cel7, was 1383 nucleotides in length and encoded a protein of 460 amino acid residues. The predicted molecular weight and the isoelectric point of the A. fumigatus Cel7 gene product were 48.19kDa and 5.03, respectively. A catalytic domain in the N-terminal region and a fungal type cellulose-binding domain/module in the C-terminal region were detected in the predicted polypeptide sequences...
February 3, 2018: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/29444760/risk-factors-for-persistent-aspergillus-respiratory-isolation-in-cystic-fibrosis
#5
Gina Hong, Kevin J Psoter, Mark T Jennings, Christian A Merlo, Michael P Boyle, Denis Hadjiliadis, Steven M Kawut, Noah Lechtzin
BACKGROUND: Aspergillus species are increasingly detected in the respiratory tracts of individuals with cystic fibrosis (CF), and chronic Aspergillus fumigatus is associated with more frequent hospitalizations for pulmonary exacerbations. However, patient and clinical factors that may contribute to the acquisition of persistent Aspergillus infection have yet to be identified. The objective of this study was to identify risk factors for development of Aspergillus respiratory isolation in CF...
February 12, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29432912/in-vitro-evaluation-of-new-2-phenoxy-benzo-g-1-2-4-triazolo-1-5-a-quinazoline-derivatives-as-antimicrobial-agents
#6
Hatem A Abuelizz, Rabab A El-Dib, Mohamed Marzouk, Rashad Al-Salahi
Previously, seventeen 2-phenoxy-benzo[g][1,2,4]triazolo[1,5-a]quinazoline derivatives were prepared and characterized by physicochemical and spectral means. This study was conducted to evaluate their activities in vitro against five Gram-negative and five Gram-positive of clinically pathogenic bacterial strains and ten fungal strains. The antimicrobial activity was assessed, and the minimum inhibitory concentration values of the tested compounds were determined in μg ml-1 , using the diffusion agar technique...
February 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29430385/host-response-to-pulmonary-fungal-infections-a-highlight-on-cell-driven-immunity-to-cryptococcus-species-and-aspergillus-fumigatus
#7
Orchi Dutta, Jorge A Masso-Silva, Keyi Wang, Amariliz Rivera
No abstract text is available yet for this article.
December 2017: Current Pharmacology Reports
https://www.readbyqxmd.com/read/29428409/transplant-tourism-and-invasive-fungal-infection
#8
I Al Salmi, A M Metry, F Al Ismaili, A Hola, M Al Riyami, F Khamis, S Al-Abri
BACKGROUND: Deceased and live-related renal transplants (RTXs) are widespread approved methods throughout the world. In addition, commercial RTX has become popular in certain places driven by financial greed. METHOD: This is a retrospective, descriptive study was done at the Royal Hospital (RH) from 2013 to 2015. The data have been collected from the national Oman kidney transplant registry. All transplant cases retrieved were divided into two groups, Live-related-RTX performed in Oman and commercial-unrelated-RTX performed abroad...
February 8, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29425123/aspergillus-fumigatus-detection-and-risk-factors-in-patients-with-copd-bronchiectasis-overlap
#9
Stephanie Everaerts, Katrien Lagrou, Kristina Vermeersch, Lieven J Dupont, Bart M Vanaudenaerde, Wim Janssens
The role of Aspergillus fumigatus in the airways of chronic obstructive pulmonary disease (COPD) patients with bronchiectasis is currently unclear. We searched for a sensitive and noninvasive method for A. fumigatus detection in the sputum of COPD patients and addressed potential risk factors for its presence. Induced sputum samples of 18 COPD patients and 17 COPD patients with bronchiectasis were analyzed for the presence of A. fumigatus by culture, galactomannan detection, and PCR. Of the patients with COPD-bronchiectasis overlap, 23...
February 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29423632/murine-model-to-follow-hyphal-development-in-invasive-pulmonary-aspergillosis
#10
Zsuzsa M Szigeti, Laszlo Talas, Zoltan Palicz, Peter Szentesi, Zoltan Hargitai, Laszlo Csernoch, Jozsef Balla, Istvan Pocsi, Gaspar Banfalvi, Gabor Szeman-Nagy
Aspergillus fumigatus is an opportunistic pathogen, the leading cause of invasive and disseminated aspergillosis in systemic immunocompromised patients, and an important cause of mortality. The aim of the present study was to adapt a pulmonary aspergillosis murine model, to determine pathodynamical parameters quantitatively, and to follow the progression of fungal infection in vivo. The nasal inoculation of Aspergillus conidia in mice previously subjected to immunosuppression with cyclophosphamide (CP) turned out to be a more suitable model than that of immunosuppressed with hydrocortisone (HC)...
February 8, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29422272/comparative-evaluation-of-different-gradient-diffusion-tests-for-detection-of-azole-resistance-in-aspergillus-fumigatus
#11
Evgeny A Idelevich, Uwe Groß, Karsten Becker, Oliver Bader
Gradient diffusion assays Etest and MIC Test Strip for itraconazole, posaconazole and voriconazole as well as isavuconazole (MIC Test Strip) were evaluated for Aspergillus fumigatus against EUCAST broth microdilution. Both assays demonstrated generally good performance; however, posaconazole MIC Test Strip showed low agreement with broth microdilution due to MIC overestimation.
January 9, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29420778/deletion-of-aspergillus-nidulans-gdp-mannose-transporters-affects-hyphal-morphometry-cell-wall-architecture-spore-surface-character-cell-adhesion-and-biofilm-formation
#12
Ashraf A Kadry, Amira M El-Ganiny, Rasha A Mosbah, Susan G W Kaminskyj
Systemic human fungal infections are increasingly common. Aspergillus species cause most of the airborne fungal infections. Life-threatening invasive aspergillosis was formerly found only in immune-suppressed patients, but recently some strains of A. fumigatus have become primary pathogens. Many fungal cell wall components are absent from mammalian systems, so they are potential drug targets. Cell-wall-targeting drugs such as echinocandins are used clinically, although echinocandin-resistant strains were discovered shortly after their introduction...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29420763/analysis-of-the-in-vitro-activity-of-human-neutrophils-against-aspergillus-fumigatus-in-presence-of-antifungal-and-immunosuppressive-agents
#13
Christina Decker, Sebastian Wurster, Maria Lazariotou, Anna-Maria Hellmann, Hermann Einsele, Andrew J Ullmann, Jürgen Löffler
Neutrophils are essential in the first line defense against moulds. This in vitro study assessed different neutrophil effector mechanisms in the presence of clinically relevant antifungal and immunosuppressive agents. Therapeutic concentrations of liposomal amphotericin B led to reduced IL-8 and oxidative burst response to the synthetic stimulus PMA, whereas no major alterations of oxidative burst, phagocytosis, or cytokine response to germinated stages of Aspergillus fumigatus and no supra-additive effects of antifungal and immunosuppressive drugs were observed...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29414772/fungal-melanin-stimulates-surfactant-protein-d-mediated-opsonization-of-and-host-immune-response-to-em-aspergillus-fumigatus-em-spores
#14
Sarah Sze Wah Wong, Manjusha Rani, Eswari Dodagatta-Marri, Oumaima Ibrahim-Granet, Uday Kishore, Jagadeesh Bayry, Jean-Paul Latgé, Arvind Sahu, Taruna Madan, Vishukumar Aimanianda
Surfactant protein D (SP-D), a C-type lectin and pattern-recognition soluble factor, plays an important role in immune surveillance to detect and eliminate human pulmonary pathogens. SPD has been shown to protect against infections with the most ubiquitous airborne fungal pathogen, <em>Aspergillus fumigatus</em>, but the fungal surface component(s) interacting with SP-D is unknown. Here, we show that SP-D binds to melanin pigment on the surface of <em>A. fumigatus</em> dormant spores (conidia)...
February 5, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29412110/the-sesamum-indicum-rhizosphere-associated-bacterium-a-source-of-antifungal-compound
#15
Renu Chaudhary, Meenakshi Balhara, Deepak Jangir, Mrridula Dangi, Mehak Dangi, Savita Khatri, Anil K Chhillar
BACKGROUND: The impact of fungal infections on human health has increased considerably within a past few decades. Although drugs with antifungal properties are available, but they are less effective and are associated with side effects. OBJECTIVE AND METHOD: Screening of bacterial isolates from Sesamum indicum and to investigate the antifungal activity of the screened bacterial isolates against Aspergillus sp. Co-culture assay and agar overlay were used to scrutinize the anti-Aspergillus activity...
February 5, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29410233/predominance-of-non-fumigatus-aspergillus-species-among-patients-suspected-to-pulmonary-aspergillosis-in-a-tropical-and-subtropical-region-of-the-middle-east
#16
Elnaz Zanganeh, Hossein Zarrinfar, Fariba Rezaeetalab, AbdolMajid Fata, Mohammad Tohidi, Mohammadjavad Najafzadeh, Majid Alizadeh, Seyedmojtaba Seyedmousavi
Non-fumigatus Aspergillus species are the leading cause of Aspergillus infections in the tropical and subtropical regions of the world. In a prospective study between 2015 and 2016, a total of 150 bronchoalveolar (BAL) specimens was collected from patients suspected to pulmonary aspergillosis (PA) underlying immunodeficiencies in Mashhad, Northeastern Iran, located in the Middle East. All Aspergillus strains were phylogenetically identified at the species level by PCR-sequencing of partial β-tubulin gene. Overall, Aspergillus species were isolated from 20 specimens originating from 10 (50%) patients with cancer, 5 (25%) patients receiving corticosteroid therapy, 3 (15%) organ transplant recipients and 2 (10%) patients admitted to intensive care unit (ICU)...
January 31, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29404711/the-emerging-threat-of-antifungal-resistance-in-transplant-infectious-diseases
#17
REVIEW
Ilan S Schwartz, Thomas F Patterson
PURPOSE OF REVIEW: The global emergence of antifungal resistance among Candida spp. and Aspergillus spp. will disproportionately affect transplantation recipients, who are prone to invasive fungal disease. RECENT FINDINGS: Invasive candidiasis is increasingly caused by non-albicans Candida species with reduced susceptibility to first-line antifungals. Echinocandin resistance in Candida glabrata is increasing in some settings. Candida auris has rapidly emerged as a global concern due to multidrug resistance and efficient nosocomial spread in healthcare settings...
February 5, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29402803/identification-of-immunoglobulin-e-binding-proteins-of-the-xerophilic-fungus-aspergillus-penicillioides-crude-mycelial-mat-extract-and-serological-reactivity-assessment-in-subjects-with-different-allergen-reactivity-profiles
#18
Joenice González De León, Ricardo González Méndez, Carmen L Cadilla, Félix E Rivera-Mariani, Benjamín Bolaños-Rosero
BACKGROUND: Aspergillus penicillioides is a very common indoor xerophilic fungus and potential causative agent of respiratory conditions. Although people are constantly exposed to A. penicillioides, no proteins with allergenic potential have been described. Therefore, we aim to confirm allergic sensitization to A. penicillioides through reactivity in serological assays and detect immunoglobulin E (IgE)-binding proteins. METHODS: In an indirect ELISA, we compared the serological reactivity to A...
February 3, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29401615/differential-susceptibility-of-dectin-1-isoforms-to-functional-inactivation-by-neutrophil-and-fungal-proteases
#19
James S Griffiths, Aiysha Thompson, Matthew Stott, Ankita Benny, Natalie A Lewis, Philip R Taylor, Julian Forton, Sarah Herrick, Selinda J Orr, Eamon P McGreal
Patients with cystic fibrosis (CF) experience chronic or recurrent bacterial and fungal lung infections. Many patients with CF cannot effectively clear Aspergillus from their lungs. This may result in IgE sensitization and the development of allergic bronchopulmonary aspergillosis, or invasive infections, such as Aspergillus bronchitis. Lung disease in patients with CF is associated with neutrophil-dominated inflammation and elevated levels of the serine protease, neutrophil elastase (NE). Various C-type lectin-like receptors (CLRs), including Dectin-1 and Dectin-2, are involved in the immune response to Aspergillus...
January 22, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29394399/epidemiology-of-invasive-aspergillosis-and-triazole-resistant-aspergillus-fumigatus-in-patients-with-haematological-malignancies-a-single-centre-retrospective-cohort-study
#20
P P Lestrade, W J F M van der Velden, F Bouwman, F J Stoop, N M A Blijlevens, W J G Melchers, P E Verweij, J P Donnelly
Objectives: To investigate the epidemiology and clinical relevance of triazole resistance among patients undergoing treatment for haematological malignancies who are at risk of invasive aspergillosis (IA). Methods: This was a retrospective cohort study for which the records of consecutive patients given chemotherapy for AML or myelodysplastic syndrome (MDS) or who had received an allogeneic HSCT from 2006 to 2012 were reviewed for IA. Triazole resistance was detected by the VIPcheck™ screening method and confirmed by determining the MIC by EUCAST methodology...
January 31, 2018: Journal of Antimicrobial Chemotherapy
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