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https://www.readbyqxmd.com/read/29331221/mechanisms-of-changes-in-functional-mitral-regurgitation-by-preload-alterations
#1
Atsuko Furukawa, Yukio Abe, Kazato Ito, Shingo Hosogi, Katsuhito Yamamoto, Hiroshi Ito
BACKGROUND: This study aimed to investigate the mechanisms of acute changes in functional mitral regurgitation (FMR) by preload alterations. METHODS: Twenty-two consecutive patients with left ventricular ejection fraction <40% and at least mild FMR underwent transthoracic echocardiography. Passive leg lifting and sublingual administration of nitroglycerin were performed to alter preload. Mitral regurgitant volume (MRV) was assessed using the Doppler method. RESULTS: MRV changed in parallel with preload alterations...
January 10, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29311053/reversing-the-cardiac-effects-of-sedentary-aging-in-middle-age-a-randomized-controlled-trial-implications-for-heart-failure-prevention
#2
Erin J Howden, Satyam Sarma, Justin S Lawley, Mildred Opondo, William Cornwell, Douglas Stoller, Marcus A Urey, Beverley Adams-Huet, Benjamin D Levine
Background - Poor fitness in middle age is a risk factor for heart failure, particularly heart failure with a preserved ejection fraction. The development of heart failure with a preserved ejection fraction is likely mediated through increased left ventricular (LV) stiffness, a consequence of sedentary aging. In a prospective, parallel group, randomized controlled trial, we examined the effect of 2 years of supervised highintensity exercise training on LV stiffness. Methods - Sixty-one (48% male) healthy, sedentary, middle-aged participants (53±5 years) were randomly assigned to either 2 years of exercise training (n=34) or attention control (control; n=27)...
January 8, 2018: Circulation
https://www.readbyqxmd.com/read/29306544/altered-left-ventricular-geometry-and-torsional-mechanics-in-high-altitude-induced-pulmonary-hypertension-a-three-dimensional-echocardiographic-study
#3
Bart W De Boeck, Aurel Toma, Stephanie Kiencke, Christoph Dehnert, Stefanie Zügel, Christoph Siebenmann, Katja Auinger, Peter T Buser, Marco Maggiorini, Beat A Kaufmann
BACKGROUND: Changes in left ventricular (LV) torsion have been related to LV geometry in patients with concomitant long-standing myocardial disease or pulmonary hypertension (PH). We evaluated the effect of acute high altitude-induced isolated PH on LV geometry, volumes, systolic function, and torsional mechanics. METHODS: Twenty-three volunteers were prospectively studied at low altitude and after the second (D3) and third night (D4) at high altitude (4,559 m)...
January 3, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29305313/effectiveness-of-the-gocheck-kids-vision-screener-in-detecting-amblyopia-risk-factors
#4
M Millicent W Peterseim, Ryan S Rhodes, Rupa N Patel, M Edward Wilson, Luke E Edmondson, Sarah A Logan, Edward W Cheeseman, Emily Shortridge, Rupal H Trivedi
Effectiveness of the GoCheck Kids Vision Screener in Detecting Amblyopia Risk Factors, MMW Peterseim, RS Rhodes, RN Patel, ME Wilson, LE Edmondson, SA Logan, EW Cheeseman, E Shortridge, RH Trivedi. INTRODUCTION: The GoCheck Kids smartphone photoscreening app (Gobiquity Mobile Health, Scottsdale, Arizona), introduced in 2014, is marketed to pediatricians with little published validation. We wished to evaluate the GoCheck Kids Screener for accuracy in detecting amblyopia risk factors (ARF) using 2013 AAPOS guidelines...
January 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29305235/validation-of-isometric-tetanic-force-as-a-measure-of-muscle-recovery-after-nerve-injury-in-the-rabbit-biceps
#5
Kathleen M Kollitz, Guilherme Giusti, Patricia F Friedrich, Allen T Bishop, Alexander Y Shin
PURPOSE: The purpose of this study was to describe and validate a technique for measurement of isometric tetanic force (ITF) in the rabbit biceps muscle. MATERIALS AND METHODS: Eighteen New Zealand White rabbits were randomized to test either the right side or the left side first. Under propofol anesthesia, the brachial plexus and biceps brachii were exposed. The middle trunk (C6, C7) was secured in a bipolar electrode. Compound muscle action potential (CMAP) was measured...
January 3, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29302289/preload-loss-of-abutment-screws-after-dynamic-fatigue-in-single-implant-supported-restorations-a-systematic-review
#6
REVIEW
Beatriz Pardal-Peláez, Javier Montero
Background: To carry out a systematic literature review of the causes of preload loss of the abutment screws, of internal and external connection implants, tightened to different torque values and subjected to cyclic loading. Material and Methods: A systematic search was conducted in PubMed, EMBASE, and Cochrane Library databases with reference to in vitro studies in which internal and external connection implants were subjected to cyclic loads to determine the degree of loosening of the abutment screws after loading...
November 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29300906/postoperative-left-ventricular-function-in-different-types-of-pulmonary-hypertension-a-comparative-study
#7
Tom Verbelen, Alexander Van De Bruaene, Bjorn Cools, Dirk Van Raemdonck, Marion Delcroix, Filip Rega, Bart Meyns
OBJECTIVES: Left ventricular dysfunction after pulmonary endarterectomy is well described. Left ventricular failure has only been described after lung transplantation for pulmonary arterial hypertension (PAH). We sought to identify factors that contribute to this failure and hypothesized that atrial septostomy before transplantation could prevent this complication. METHODS: From our database, all bilateral lung transplants for PAH (n = 24) and all pulmonary endarterectomies, with a minimal reduction of 800 dyn⋅s⋅cm-5 (n = 27), were selected...
January 2, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29298772/the-impact-of-preload-reduction-with-head-up-tilt-testing-on-longitudinal-and-transverse-left-ventricular-mechanics
#8
Caroline Schneider, Lynsey Forsythe, John Somauroo, Keith George, David Oxborough
BACKGROUND: Left ventricular (LV) function is dependent on load, intrinsic contractility and relaxation with a variable impact on specific mechanics. Strain (ε) imaging allows the assessment of cardiac function however the direct relationship between volume and strain is currently unknown. The aim of this study was to establish the impact of preload reduction through head-up tilt (HUT) testing on simultaneous left ventricular (LV) longitudinal and transverse function and their respective contribution to volume change...
January 3, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29298377/cupric-phosphate-nanosheets-wrapped-inorganic-membranes-with-superhydrophilic-and-outstanding-anti-crude-oil-fouling-property-for-oil-water-separation
#9
Shenxiang Zhang, Gaoshuo Jiang, Shoujian Gao, Huile Jin, Yuzhang Zhu, Feng Zhang, Jian Jin
Developing an effective and sustainable solution for cleaning up or separating oily water is highly desired. In this work, we report a completely new inorganic mesh membrane made up of cupric phosphate (Cu3(PO4)2) in a special nanosheets-constructed honeycomb-like structure. Combing the unique hierarchical structure with strong hydration ability of Cu3(PO4)2, the nanosheets-wrapped membrane exhibits a superior superhydrophilic and underwater anti-oil fouling and anti-bio fouling property for efficient oil/water separation to various viscous oils such as heavy diesel oil, light crude oil, and even heavy crude oil with underwater oil contact angles (CAs) all above 158° and nearly zero underwater oil adhesive force even when a large preload force up to 400 μN applied on the oil droplet...
January 3, 2018: ACS Nano
https://www.readbyqxmd.com/read/29297963/matrix-approach-to-the-simultaneous-detection-of-multiple-potato-pathogens-by-real-time-pcr
#10
M M Nikitin, N V Statsyuk, P A Frantsuzov, V G Dzhavakhiya, A G Golikov
AIM: Create a method for highly sensitive, selective, rapid, and easy-to-use detection and identification of economically significant potato pathogens, including viruses, bacteria and oomycetes, be it single pathogen, or a range of various pathogens occurring simultaneously. METHODS AND RESULTS: Test-systems for real-time PCR, operating in the unified amplification regime, have been developed for Phytophthora infestans, Pectobacterium atrosepticum, Dickeya dianthicola, Dickeya solani, Ralstonia solanacearum, Pectobacterium carotovorum, Clavibacter michiganensis subsp...
January 3, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29295618/the-role-of-hydrogen-bonding-on-transport-of-co-adsorbed-gases-in-metal-organic-frameworks-materials
#11
Kui Tan, Stephanie Jensen, Sebastian Zuluaga, Eric K Chapman, Hao Wang, Rezwanur Rahman, Jeremy Cure, Tae-Hyeon Kim, Jing Li, Timo Thonhauser, Yves J Chabal
Co-adsorption of multi-components in metal organic framework materials can lead to a number of cooperative effects, such as modification of adsorption sites or transport. In this work, we explore the incorporation of NH3 and H2O into MOFs preloaded with small molecules such as CO, CO2, and SO2. We find that NH3 first displaces ~50% of pre-adsorbed molecules and then substantially stabilizes the remaining gas molecules. Combining in situ spectroscopy with first-principles calculations, we show that hydrogen bonding between NH3 (or H2O) and the guest molecule directly increases the diffusion barrier (by a factor of ~7) of CO and CO2 through the MOF channel occupied with NH3 or H2O...
January 3, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29290485/tricuspid-valve-adaptation-during-the-first-interstage-period-in-hypoplastic-left-heart-syndrome
#12
Timothy Colen, Shelby Kutty, Richard B Thompson, Edythe Tham, Andrew S Mackie, Ling Li, Dongngan T Truong, Michiko Maruyama, Jeffrey F Smallhorn, Nee Scze Khoo
BACKGROUND: Tricuspid regurgitation (TR) is an important risk factor for morbidity and mortality in hypoplastic left heart syndrome (HLHS), yet the evolution of tricuspid valve (TV) dysfunction in HLHS is poorly understood. This study sought to examine changes in TV function in HLHS between the first two stages of surgical palliation and to determine the mechanism of TR at the time of stage two surgery-bidirectional cavopulmonary anastomosis (BCPA). METHODS: We prospectively investigated 44 infants at two time points-prior to Norwood-Sano (T1 - median age 5...
December 29, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29282886/biorefining-of-platinum-group-metals-from-model-waste-solutions-into-catalytically-active-bimetallic-nanoparticles
#13
Angela J Murray, Ju Zhu, Joe Wood, Lynne E Macaskie
Bacteria can fabricate platinum group metal (PGM) catalysts cheaply, a key consideration of industrial processes and waste decontaminations. Biorecovery of PGMs from wastes is promising but PGM leachates made from metallic scraps are acidic. A two-step biosynthesis 'pre-seeds' metallic deposits onto bacterial cells benignly; chemical reduction of subsequent metal from acidic solution via the seeds makes bioscaffolded nanoparticles (NPs). Cells of Escherichia coli were seeded using Pd(II) or Pt(IV) and exposed to a mixed Pd(II)/Pt(IV) model solution under H2 to make bimetallic catalyst...
December 28, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29282666/influence-of-multiwall-carbon-nanotubes-on-the-toxicity-of-17%C3%AE-estradiol-in-the-early-life-stages-of-zebrafish
#14
Zhenhua Yan, Yuxuan Liu, Hongwei Sun, Guanghua Lu
Due to increasing use and release, both multiwall carbon nanotubes (MWCNTs) and 17β-estradiol (E2) may co-exist and interact with each other in aquatic environments. However, little is known about their combined effects on non-target organisms, especially in the presence of other environmental factors. In this study, the interplay between MWCNTs and E2 in the early life stages of zebrafish was investigated, focusing on the alterations in estrogenic responses with and without other environmental factors. There were no significant differences in the hatchability, mortality, or physical development of zebrafish in any treatments...
December 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29280284/combined-effect-of-the-microstructure-and-underlying-surface-curvature-on-the-performance-of-biomimetic-adhesives
#15
Emre Kizilkan, Stanislav N Gorb
The importance of the geometry of the micro-/nanosized attachment elements for adhesive characteristics of gecko-inspired microstructured surfaces has been comprehensively discussed in recent years. Due to the complex hierarchical structure of these systems, they possess a broad range of adhesion control capabilities by either passive or active adaptability of their underlying structures to the specific substrate and/or behavioral situation. Here, the influence of macroscopic geometry of backing layers hosting biomimetic microstructured surfaces is examined...
December 27, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29275062/intravenous-infusion-of-bone-marrow-derived-mesenchymal-stem-cells-reduces-erectile-dysfunction-following-cavernous-nerve-injury-in-rats
#16
Yohei Matsuda, Masanori Sasaki, Yuko Kataoka-Sasaki, Akio Takayanagi, Ko Kobayashi, Shinichi Oka, Masahito Nakazaki, Naoya Masumori, Jeffery D Kocsis, Osamu Honmou
INTRODUCTION: Intravenous preload (delivered before cavernous nerve [CN] injury) of bone marrow-derived mesenchymal stem cells (MSCs) can prevent or decrease postoperative erectile dysfunction (J Sex Med 2015;12:1713-1721). In the present study, the potential therapeutic effects of intravenously administered MSCs on postoperative erectile dysfunction were evaluated in a rat model of CN injury. METHODS: Male Sprague-Dawley rats were randomized into 2 groups after electric CN injury...
December 20, 2017: Sexual Medicine
https://www.readbyqxmd.com/read/29260183/mobilization-of-iron-from-ferritin-new-steps-and-details
#17
A La, T Nguyen, K Tran, E Sauble, D Tu, A Gonzalez, T Z Kidane, C Soriano, J Morgan, M Doan, K Tran, C-Y Wang, M D Knutson, M C Linder
Much evidence indicates that iron stored in ferritin is mobilized through protein degradation in lysosomes, but concerns about this process have lingered, and the mechanistic details of its aspects are lacking. In the studies presented here, 59Fe-labeled ferritin was induced by preloading hepatic (HepG2) cells with radiolabeled Fe. Placing these cells in a medium containing desferrioxamine resulted in the loss of ferritin-59Fe, but adding high concentrations of reducing agents or modulating the internal GSH concentration failed to alter the rates of ferritin-59Fe release...
December 20, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29251108/sertoli-cells-loaded-with-doxorubicin-in-lipid-micelles-reduced-tumor-burden-and-dox-induced-toxicity
#18
Mahasweta Das, Mark Howell, Elspeth A Foran, Rohit Iyre, Shyam S Mohapatra, Subhra Mohapatra
The toxic side effects of doxorubicin (Dox) limit its long-term use as a lung cancer chemotherapeutic. Additionally, drug delivery to the deep lung is challenging. To address these challenges, isolated rat Sertoli cells (SCs) were preloaded with Dox conjugated to lipid micelle nanoparticles (SC-DLMNs) and delivered to mouse lungs. These immunocompetent cells, when injected intravenously, travel to the lung, deliver the payload, and get cleared by the system quickly without causing any adverse reaction. We observed that SC-DLMNs effectively treated Lewis lung carcinoma 1-induced lung tumors in mice and the drug efficacy was comparable to SC-Dox treatment...
October 2017: Cell Transplantation
https://www.readbyqxmd.com/read/29249330/is-there-a-crystal-ball-for-predicting-the-outcome-of-cardiomyopathy-surgery-preload-recruitable-stroke-work-may-be-a-possible-candidate
#19
EDITORIAL
Shigeki Morita
No abstract text is available yet for this article.
December 14, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29223594/femoral-neck-fractures-after-removal-of-hardware-in-healed-trochanteric-fractures
#20
REVIEW
Antonio Barquet, Peter V Giannoudis, Andrés Gelink
INTRODUCTION: Hardware removal in healed trochanteric fractures (TF) in the absence of infection or significant mechanical complications is rarely indicated. However, in patients with persistent pain, prominent material and discomfort in the activities of daily living, the implant is eventually removed. Publications of ipsilateral femoral neck fracture after removal of implants from healed trochanteric fractures (FNFARIHTF) just because of pain or discomfort are rare. The purpose of this systematic review of the literature is to report on the eventual risk factors, the mechanisms, the clinical presentation, and frequency, and to pay special emphasis in their prevention...
December 2017: Injury
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