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https://www.readbyqxmd.com/read/28927342/expert-opinion-biomimetic-functionalized-surfaces-and-the-induction-of-bone-formation
#1
Ugo Ripamonti
Tissue engineering still needs to assign the molecular basis of pattern formation, tissue induction and morphogenesis: What next to morphogens and stem cells? Macroporous biomimetic matrices per se, without the addition of the soluble osteogenic molecular signals of the transforming growth factor-β (TGF-β) supergene family, initiate the induction of bone formation. Carving geometries within different calcium phosphate-based macroporous bioreactors we show that geometric cues imprinted within the macroporous spaces initiate the spontaneous induction of bone...
September 19, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28915925/biomechanical-analysis-of-the-posterior-bony-column-of-the-lumbar-spine
#2
Jiukun Li, Shuai Huang, Yubo Tang, Xi Wang, Tao Pan
BACKGROUND: Each part of the rear bone structure can become an anchor point for an attachment device. The objective of this study was to evaluate the stiffness and strength of different parts of the rear lumbar bone structure by axial compression damage experiments. METHODS: Five adult male lumbar bone structures from L2 to L5 were exposed. The superior and inferior articular processes, upper and lower edges of the lamina, and upper and lower edges of the spinous process were observed and isolated and then divided into six groups (n = 10)...
September 15, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28910701/biomechanical-analysis-of-lumbar-decompression-surgery-in-relation-to-degenerative-changes-in-the-lumbar-spine-validated-finite-element-analysis
#3
Quan You Li, Ho-Joong Kim, Juhyun Son, Kyoung-Tak Kang, Bong-Soon Chang, Choon-Ki Lee, Hyun Sik Seok, Jin S Yeom
BACKGROUND: There are no studies about the biomechanical analysis of lumbar decompression surgery in relation to degenerative changes of the lumbar spine. Therefore, the purpose of this study was to compare, by using finite element (FE) analysis, the biomechanical changes of the lumbar spine in terms of annulus stress and nucleus pressure after two different kinds of lumbar decompression surgery in relation to disc degenerative changes. METHODS: The validated intact and degenerated FE models (L2-5) were used in this study...
September 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28902381/-organ-interactions-heart-and-lung-management-of-the-acute-right-heart-failure
#4
Guido Michels, Roman Pfister
The pathophysiology and the management of patients with acute right heart failure are very complex. The bed-side focused echocardiography is the basis of differential diagnosis and acute diagnosis. Individual therapy monitoring is complex due to the strong preload dependence of the right ventricle and the limitation of non-invasive estimation of pulmonary-vascular hemodynamics, so that the indication for a pulmonary artery catheter should be liberal in acute right heart failure. The treatment goals of acute right heart failure are the treatment of the underlying disease or triggering factors in combination with individualized optimization of hemodynamic tailored to current right-ventricular function...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28902380/-organ-interactions-heart-and-kidney
#5
Daniel Salleck, Stefan John
The interactions between heart and kidney are various and of clinical relevance. Worsening of one organ often influences the function of the other. With NYHA and KDIGO we have classification systems for heart and kidney failure and those should be used for cardiorenal systems as well. Furthermore there is a useful classification system for cardiorenal syndromes itself. Cardiorenal syndrome is a complex illness which should be treated by interdisciplinary medical teams. A key roll in pathophysiology is the renin-angiotensin-aldosteron-system (RAAS)...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28900761/a-novel-multi-objective-physiological-control-system-for-rotary-left-ventricular-assist-devices
#6
Anastasios Petrou, Marcial Monn, Mirko Meboldt, Marianne Schmid Daners
Various control and monitoring algorithms have been proposed to improve the left-ventricular assist device (LVAD) therapy by reducing the still-occurring adverse events. We developed a novel multi-objective physiological control system that relies on the pump inlet pressure (PIP). Signal-processing algorithms have been implemented to extract the required features from the PIP. These features then serve for meeting various objectives: pump flow adaptation to the perfusion requirements, aortic valve opening for a predefined time, augmentation of the aortic pulse pressure, and monitoring of the LV pre- and afterload conditions as well as the cardiac rhythm...
September 12, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28899401/the-impact-of-preload-on-3-dimensional-deformation-parameters-principal-strain-twist-and-torsion
#7
Hyo-Suk Ahn, Yong-Kyun Kim, Ho Chul Song, Euy Jin Choi, Gee-Hee Kim, Jung Sun Cho, Sang-Hyun Ihm, Hee-Yeol Kim, Chan Seok Park, Ho-Joong Youn
BACKGROUND: Strain analysis is feasible using three-dimensional (3D) echocardiography. This approach provides various parameters based on speckle tracking analysis from one full-volume image of the left ventricle; however, evidence for its volume independence is still lacking. METHODS: Fifty-eight subjects who were examined by transthoracic echocardiography immediately before and after hemodialysis (HD) were enrolled. Real-time full-volume 3D echocardiographic images were acquired and analyzed using dedicated software...
September 12, 2017: Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28895094/fluid-loading-and-norepinephrine-infusion-mask-the-left-ventricular-preload-decrease-induced-by-pleural-effusion
#8
Kristian Borup Wemmelund, Viktor Kromann Ringgård, Simon Tilma Vistisen, Janus Adler Hyldebrandt, Erik Sloth, Peter Juhl-Olsen
BACKGROUND: Pleural effusion (PLE) may lead to low blood pressure and reduced cardiac output. Low blood pressure and reduced cardiac output are often treated with fluid loading and vasopressors. This study aimed to determine the impact of fluid loading and norepinephrine infusion on physiologic determinants of cardiac function obtained by ultrasonography during PLE. METHODS: In this randomised, blinded, controlled laboratory study, 30 piglets (21.9 ± 1.3 kg) had bilateral PLE (75 mL/kg) induced...
September 11, 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28893709/novel-application-of-branched-endograft-for-preservation-of-pelvic-circulation
#9
Roy Miler, Jeanwan Kang, Patrick Sowa, Matthew Eagleton, F Ezequiel Parodi
INTRODUCTION/OBJECTIVES: Endovascular repair of a proximal anastomotic pseudoaneurysm of an end-to-side aortobifemoral bypass (ABF) can lead to pelvic ischemia. We present a novel application of branched aortic endograft to repair such pseudoaneurysm while preserving flow into the ABF and native aortoiliac system. METHODS: A 71 year old male with history of aortoiliac occlusive disease resulting in lifestyle limiting claudication was treated with an aortobifemoral bypass in 1999...
September 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28891509/role-of-the-medullary-lateral-tegmental-field-in-sympathetic-control
#10
Michael George Zaki Ghali
The sympathetic nervous system maintains and regulates arterial pressure and tissue perfusion, via control of cardiac output and vasomotor tone. Sympatho-vascular-mediated increases in blood pressure are effected by arterioloconstriction, which causes an increase in afterload, and/or venoconstriction, which increases venous return, left ventricular preload, and consequently, the force of cardiac contraction via Frank-Starling mechanisms; withdrawal of sympathetic drive elicits reciprocal effects. Spinalization reduces mammalian arterial pressure to 40-50 mm Hg consequent to the elimination of descending medullary pre-sympathetic bulbospinal drive to preganglionic sympathetic fibers in the intermediolateral cell column of the spinal cord...
2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28888229/changes-in-ankle-joint-motion-after-supramalleolar-osteotomy-a-cadaveric-model
#11
Hak Jun Kim, Eui Dong Yeo, Im Joo Rhyu, Soon-Hyuck Lee, Yeon Soo Lee, Young Koo Lee
BACKGROUND: Malalignment of the ankle joint has been found after trauma, by neurological disorders, genetic predisposition and other unidentified factors, and results in asymmetrical joint loading. For a medial open wedge supramalleolar osteotomy(SMO), there are some debates as to whether concurrent fibular osteotomy should be performed. We assessed the changes in motion of ankle joint and plantar pressure after supramalleolar osteotomy without fibular osteotomy. METHODS: Ten lower leg specimens below the knee were prepared from fresh-frozen human cadavers...
September 9, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28885476/determining-the-risk-of-sepsis-using-nurse-compounded-elastomeric-pumps-for-continuous-infusion-in-outpatient-parenteral-antibiotic-therapy
#12
Pauline M Dobson, Mark Loewenthal, Lisa Harris
Limited availability of compounded antibiotics used for continuous infusion outpatient parenteral antibiotic therapy (OPAT) can delay or interrupt an OPAT course. To solve this problem, OPAT nurses at a hospital in Australia have been compounding elastomeric pumps for immediate use. The incidence of sepsis in 5014 patients before and after the introduction of nurse compounding was compared. There were no cases of laboratory-confirmed bloodstream infection among the nurse-compounded group compared with 2 cases (0...
September 2017: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/28875533/expanding-anti-stokes-shifting-in-triplet-triplet-annihilation-upconversion-for-in-vivo-anticancer-prodrug-activation
#13
Huang Ling, Yang Zhao, He Zhang, Kai Huang, Jingyi Yang, Gang Han
A strategy to expand anti-Stokes shifting from the far-red to deep-blue in metal-free triplet-triplet annihilation(TTA) upconversion is presented and its utility in the in vivo titration of the photorelease of an anticancer prodrug is demonstrated. This new TTA system has robust brightness and the longest anti-Stokes shift of any reported TTA system. TTA core-shell-structured prodrug delivery capsules that benefit from these properties are developed; they can operate with low-power far-red LED light. These capsules contain mesoporous silica nanoparticles preloaded with TTA molecules as the core and amphiphilic polymers encapsulating prodrugs as the shell...
September 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28874990/in-vitro-study-of-the-fracture-resistance-of-monolithic-lithium-disilicate-monolithic-zirconia-and-lithium-disilicate-pressed-on-zirconia-for-three-unit-fixed-dental-prostheses
#14
Jae-Won Choi, So-Yeun Kim, Ji-Hyeon Bae, Eun-Bin Bae, Jung-Bo Huh
PURPOSE: The purpose of this study was to determine fracture resistance and failure modes of three-unit fixed dental prostheses (FDPs) made of lithium disilicate pressed on zirconia (LZ), monolithic lithium disilicate (ML), and monolithic zirconia (MZ). MATERIALS AND METHODS: Co-Cr alloy three-unit metal FDPs model with maxillary first premolar and first molar abutments was fabricated. Three different FDPs groups, LZ, ML, and MZ, were prepared (n = 5 per group)...
August 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28874030/synergistic-effects-of-remote-perconditioning-with-terminal-blood-cardioplegia-in-an-in-vivo-piglet-model
#15
Takayuki Abe, Kiyozo Morita, Gen Shinohara, Kazuhiro Hashimoto, Masako Nishikawa
OBJECTIVES: This study tested the hypothesis that remote perconditioning offers effective and synergistic cardioprotection to terminal warm blood cardioplegia for prompt ventricular recovery after prolonged cardioplegic arrest in an in vivo piglet model. METHODS: Twenty-four piglets were subjected to 120 min of single-dose cardioplegic arrest and were divided into 4 groups according to the mode of reperfusion: control (simple aortic unclamp), remote perconditioning, terminal warm blood cardioplegia or remote perconditioning + terminal warm blood cardioplegia; remote perconditioning (4 cycles of 5-min ischaemia-reperfusion of the lower limb) was applied prior to aortic unclamping...
September 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28872728/changes-to-glazed-dental-ceramic-shade-roughness-and-microhardness-after-bleaching-and-simulated-brushing
#16
Carlos Roberto Teixeira Rodrigues, Cecilia Pedroso Turssi, Flávia Lucisano Botelho Amaral, Roberta Tarkany Basting, Fabiana Mantovani Gomes França
PURPOSE: To evaluate shade stability, surface roughness, microhardness, and compressive strength of a glazed feldspathic ceramic subjected to bleaching and simulated brushing. MATERIALS AND METHODS: Eighty-eight glazed feldspathic ceramic specimens were made from microparticulate leucite and divided into eight groups (n = 10). The whitening products used were: Opalescence Trèswhite Supreme (Ultradent), Opalescence®\ PF 15% (Ultradent), and Oral-B 3D White Whitestrips...
September 5, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/28870473/short-term-effects-of-a-low-glycemic-index-carob-containing-snack-on-energy-intake-satiety-and-glycemic-response-in-normal-weight-healthy-adults-results-from-two-randomized-trials
#17
Emilia Papakonstantinou, Nickolaos Orfanakos, Paul Farajian, Anastasia E Kapetanakou, Ifigenia P Makariti, Nikolaos Grivokostopoulos, Marie-Ann Ha, Panagiotis N Skandamis
OBJECTIVES: The potential positive health effects of carob-containing snacks are largely unknown. Therefore, the aims of these studies were to determine the glycemic index (GI) of a carob snack compared with chocolate cookie containing equal amounts of available carbohydrates and to compare the effects of a carob versus chocolate cookie preload consumed as snack before a meal on (a) short-term satiety response measured by subsequent ad libitum meal intake, (b) subjective satiety as assessed by visual analog scales and (c) postprandial glycemic response...
October 2017: Nutrition
https://www.readbyqxmd.com/read/28869639/analysis-of-the-influence-of-the-transducer-and-its-coupling-layer-on-round-window-stimulation
#18
Houguang Liu, Dan Xu, Jianhua Yang, Shanguo Yang, Gang Cheng, Xinsheng Huang
PURPOSE: In this work, a finite element study is proposed to evaluate the effects of the transducer and its coupling layer on the performance of round window (RW) stimulation. METHODS: Based on a set of micro-computer tomography images of a healthy adult's right ear and reverse engineering technique, a coupled finite-element model of the human ear and the transducer was constructed and verified. Then, the effect of the cross-section of the transducer, the elastic modulus of the coupling layer, the mass of the transducer, and the preload of the transducer were studied...
2017: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/28867649/synthesis-and-characterization-of-arginine-nipaam-hybrid-hydrogel-as-wound-dressing-in-vitro-and-in-vivo-study
#19
De-Qun Wu, Jie Zhu, Hua Han, Jun-Zhi Zhang, Fei-Fei Wu, Xiao-Hong Qin, Jian-Yong Yu
A multi-functional hybrid hydrogel P(M-Arg/NIPAAm) with temperature response, anti-protein adsorption and antibacterial properties was prepared and applied as wound dressing. The hydrogel was carried out by free radical copolymerization of methacrylate arginine (M-Arg) and N-isopropyl acrylamide (NIPAAm) monomers using N, N'-methylene bisacrylamide as a crosslinker, and ammonium persulfate/N, N, N', N'-tetramethylethylenediamine as the redox initiator. To endow the antimicrobial property, chlorhexidine diacetate (CHX) was preloaded into the hydrogel and polyhexamethylene guanidine phosphate (PHMG) was grafted on the hydrogel surface, respectively...
August 31, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28860014/feasibility-and-safety-of-intact-cord-resuscitation-in-newborn-infants-with-congenital-diaphragmatic-hernia-cdh
#20
Caroline Lefebvre, Thameur Rakza, Nathalie Weslinck, Pascal Vaast, Véronique Houfflin-Debarge, Sébastien Mur, Laurent Storme
BACKGROUND: Starting resuscitation before clamping the umbilical cord at birth may progressively increase pulmonary blood flow while umbilical venous blood flow is still contributing to maintenance of oxygenation and left ventricle preload. OBJECTIVE: To evaluate the feasibility, safety, and effects of intact cord resuscitation (ICR) on cardiorespiratory adaptation at birth in newborn infants with CDH. STUDY DESIGN: Prospective, observational, single-center pilot study...
August 30, 2017: Resuscitation
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