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https://www.readbyqxmd.com/read/29767346/biomechanical-properties-of-suprapectoral-biceps-tenodesis-double-knotless-screw-fixation-is-superior-to-single-knotless-screw-fixation
#1
Chih-Kai Hong, Chih-Hsun Chang, Florence L Chiang, I-Ming Jou, Ping-Hui Wang, Hung-Nan Wang, Kai-Lan Hsu, Fa-Chuan Kuan, Wei-Ren Su
INTRODUCTION: The purpose of this study is to biomechanically evaluate a new technique of double knotless screw fixation for suprapectoral biceps tenodesis and compare the results with that of the single knotless screw fixation as well as the interference screw fixation. METHODS: 24 fresh-frozen human cadaveric shoulders with a mean age of 68.3 ± 9 years were studied. The specimens were randomly divided into three experimental biceps tenodesis groups (n = 8): single knotless screw, double knotless screw and interference screw...
May 16, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29765554/targeted-nanoparticle-delivery-of-therapeutic-antisense-micrornas-presensitizes-glioblastoma-cells-to-lower-effective-doses-of-temozolomide-in-vitro-and-in-a-mouse-model
#2
Meenakshi Malhotra, Thillai Veerapazham Sekar, Jeyarama S Ananta, Rammohan Devulapally, Rayhaneh Afjei, Husam A Babikir, Ramasamy Paulmurugan, Tarik F Massoud
Temozolomide (TMZ) chemotherapy for glioblastoma (GBM) is generally well tolerated at standard doses but it can cause side effects. GBMs overexpress microRNA-21 and microRNA-10b, two known oncomiRs that promote cancer development, progression and resistance to drug treatment. We hypothesized that systemic injection of antisense microRNAs (antagomiR-21 and antagomiR-10b) encapsulated in cRGD-tagged PEG-PLGA nanoparticles would result in high cellular delivery of intact functional antagomiRs, with consequent efficient therapeutic response and increased sensitivity of GBM cells to lower doses of TMZ...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29757759/mechanical-circulatory-support-of-the-right-ventricle-for-adult-and-pediatric-patients-with-heart-failure
#3
Steven G Chopski, Nohra M Murad, Carson S Fox, Randy M Stevens, Amy L Throckmorton
The clinical implementation of mechanical circulatory assistance for a significantly dysfunctional or failing left ventricle as a bridge-to-transplant or bridge-to-recovery is on the rise. Thousands of patients with left-sided heart failure are readily benefitting from these life-saving technologies, and left ventricular failure often leads to severe right ventricular dysfunction or failure. Right ventricular failure (RVF) has a high rate of mortality caused by the risk of multisystem organ failure and prolonged hospitalization for patients after treatment...
May 10, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29757475/rapid-analysis-of-fentanyls-and-other-novel-psychoactive-substances-nps-in-substance-use-disorder-patient-urine-using-paper-spray-mass-spectrometry
#4
Joseph H Kennedy, Jan Palaty, Chris G Gill, Justin M Wiseman
RATIONALE: Drug overdose deaths due to fentanyls and other novel psychoactive substances (NPS) are on the rise. The higher potencies of fentanyl analogs compared with morphine require new technologies to identify and quantitate NPS. METHODS: Paper spray tandem mass spectrometry and high-resolution mass spectrometry were used to identify and measure fentanyl analogs as well as common drugs of abuse in urine samples from substance use disorder clinics. Ten-microliter urine samples were deposited directly on paper spray cartridges previously loaded with internal standards, dried, and analyzed with no other sample treatment...
May 14, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29756656/pathophysiology-and-treatment-of-achalasia-in-a-muscle-mechanical-perspective
#5
REVIEW
Hans Gregersen, Kar Man Lo
This review provides a biomechanical perspective on the pathophysiology and treatment of achalasia. The esophagus is efficient in transporting ingested material to the stomach in healthy subjects. A fine balance exists between the peristaltic forces generated in the esophageal body (which herein is defined as the preload) and the resistance in the outlet, the esophago-gastric junction (which is defined as the afterload). Achalasia is a rare esophageal disease that progressively over many years challenges esophageal efficacy...
May 14, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29756642/reference-values-and-correlates-of-right-atrial-volume-in-healthy-adults-by-two-dimensional-echocardiography
#6
Francesco Ferrara, Luna Gargani, Saku Ruohonen, Olga Vriz, Marco Scalese, Valentina Russo, Alberto M Marra, Anna Agnese Stanziola, Antonio Cittadini, Antonello D'Andrea, Robert Naeije, Eduardo Bossone
BACKGROUND: Right atrial (RA) volume is an important parameter in the evaluation of patients with pulmonary hypertension. Aim of this study was to define reference ranges for RA volume by two-dimensional echocardiography (2DE) in healthy adults. METHODS: A total of 596 healthy subjects [mean age 45.7 ± 14.6 years, range 18-88 years; 60.1% women] underwent a transthoracic echocardiography. In addition, a meta-analysis was performed of published studies measuring RA volume in healthy subjects, using 2DE single plane area-length (A-L) and/or method of disks (MOD) at end-systole in apical four-chamber view...
May 14, 2018: Echocardiography
https://www.readbyqxmd.com/read/29756152/a-quasi-solid-state-and-self-powered-biosupercapacitor-based-on-flexible-nanoporous-gold-electrodes
#7
Xinxin Xiao, Edmond Magner
A quasi-solid-state and flexible biofuel cell using a hydrogel electrolyte preloaded with sugar as a fuel is described. The device can function as a self-powered biosupercapacitor delivering pulses for over 600 cycles, with a power density over 10 times higher than that from the biofuel cell alone.
May 14, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29753641/consistency-of-normalized-cerebral-blood-volume-values-in-glioblastoma-using-different-leakage-correction-algorithms-on-dynamic-susceptibility-contrast-magnetic-resonance-imaging-data-without-and-with-prebolus
#8
Dennis Hedderich, Anne Kluge, Thomas Pyka, Claus Zimmer, Jan S Kirschke, Benedikt Wiestler, Christine Preibisch
BACKGROUND AND PURPOSE: Several leakage correction algorithms for dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI)-based cerebral blood volume (CBV) measurement have been proposed, and combination with a preload of contrast agent is generally recommended. A single bolus application scheme would largely simplify and facilitate standardized clinical applications, while reducing contrast agent (CA) dose. The aim of this study was, therefore, to investigate whether appropriate leakage correction redundantizes prebolus application by comparing normalized DSC-based CBV (nCBV) measures of two consecutive CA boli...
May 10, 2018: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29748312/noninvasive-assessment-of-preload-reserve-enhances-risk-stratification-of-patients-with-heart-failure-with-reduced-ejection-fraction
#9
Kensuke Matsumoto, Akira Onishi, Hirotsugu Yamada, Kenya Kusunose, Makiko Suto, Yutaka Hatani, Hiroki Matsuzoe, Kazuhiro Tatsumi, Hidekazu Tanaka, Ken-Ichi Hirata
BACKGROUND: The leg-positive pressure maneuver can safely and noninvasively apply preload stress without increase in total body fluid volume. The purpose of this study was to determine whether preload stress could be useful for risk stratification of patients with heart failure with reduced ejection fraction. METHODS AND RESULTS: For this study, 120 consecutive patients with heart failure with reduced ejection fraction were prospectively recruited. The stroke work index was estimated as product of stroke volume index and mean blood pressure, and the E/e' ratio was calculated to estimate ventricular filling pressure...
May 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29748290/endogenous-fatty-acids-are-essential-signaling-factors-of-pancreatic-%C3%AE-cells-and-insulin-secretion
#10
Sebastian Hauke, Kaya Keutler, Prasad Phapale, Dmytro A Yushchenko, Carsten Schultz
The secretion of insulin from β -cells depends on extracellular factors, in particular glucose and other small molecules, some of which act on G-protein coupled receptors (GPCRs). Fatty acids (FAs) have been discussed as exogenous secretagogues of insulin for decades, especially after the FA receptor GPR40 was discovered. However, the role of FAs as endogenous signaling factor has not been investigated until now. In the present work, we demonstrate that lowering endogenous FA levels in β -cell medium by stringent washing or by the application of fatty acid-free bovine serum albumin (FAF-BSA) immediately reduced glucose-induced oscillations of cytosolic Ca2+ ([Ca2+ ]i oscillations) in MIN6 and primary β -cells, as well as insulin secretion...
May 10, 2018: Diabetes
https://www.readbyqxmd.com/read/29745523/-the-effect-of-preload-and-support-s-stiffness-on-the-performance-of-round-window-stimulation-a-numerical-analysis
#11
Hu Zhang, Houguang Liu, Yu Zhao, Zhushi Rao, Jianhua Yang, Wenbo Wang
To investigate the influence of the preload and supporting stiffness on the hearing compensation performance of round window stimulation, a coupling finite model composed of a human ear, an actuator and a support was established. This model was constructed based on a complete set of micro-computed tomography (Micro-CT) images of a healthy adult's right ear by reverse engineering technology. The validity of the model was verified by comparing the model's calculated results with experimental data. Based on this model, we applied different amplitude preloads on the actuator, and changed the support's stiffness...
April 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744563/diagnostic-workup-etiologies-and-management-of-acute-right-ventricle-failure-a-state-of-the-art-paper
#12
REVIEW
Antoine Vieillard-Baron, R Naeije, F Haddad, H J Bogaard, T M Bull, N Fletcher, T Lahm, S Magder, S Orde, G Schmidt, M R Pinsky
INTRODUCTION: This is a state-of-the-art article of the diagnostic process, etiologies and management of acute right ventricular (RV) failure in critically ill patients. It is based on a large review of previously published articles in the field, as well as the expertise of the authors. RESULTS: The authors propose the ten key points and directions for future research in the field. RV failure (RVF) is frequent in the ICU, magnified by the frequent need for positive pressure ventilation...
May 9, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29742951/carotid-flow-as-a-surrogate-for-cardiac-output-measurement-in-hemodynamically-stable-participants
#13
Marian Sidor, Lalith Premachandra, Bishoy Hanna, Nanda Nair, Amit Misra
OBJECTIVE: Evaluation of common carotid artery (CCA) blood flow can provide valuable information regarding the hemodynamic status of a patient. Utilizing ultrasound, we aimed to evaluate the correlation between cardiac output and different hemodynamic parameters in the CCA, namely systolic carotid flow (SCF), corrected flow time (CFT), and total carotid flow (TCF). METHODS: We studied a pilot sample of 20 healthy volunteers. Hemodynamic parameters were collected in the right CCA and the heart at rest (baseline), 1-leg compression, 2-leg compression, and passive leg raise...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29740652/novel-ss-31-modified-liposomes-for-improved-protective-efficacy-of-minocycline-against-drug-induced-hearing-loss
#14
Shanshan Hou, Yang Yang, Shuang Zhou, Xiao Kuang, YinXian Yang, Hailing Gao, Zhenjie Wang, Hongzhuo Liu
Hearing loss, which is regarded as a worldwide public health concern, lacks approved therapeutic strategies. Current drug candidates used to treat hearing loss commonly have low efficacy. To achieve the optimum drug efficacy, we designed a liposome system to preload a clinically approved, water-soluble drug, minocycline. Inspired by our previous research, we used a mitochondria-targeting tetrapeptide, SS-31, to modify the surface of liposomes. The results revealed that SS-31 modified, minocycline-loaded liposomes significantly increased hair cell survival against chronic exposure to gentamicin in a zebrafish model...
May 9, 2018: Biomaterials Science
https://www.readbyqxmd.com/read/29739798/single-beat-estimation-of-right-ventricular-contractility-and-its-coupling-to-pulmonary-arterial-load-in-patients-with-pulmonary-hypertension
#15
Ryo Inuzuka, Steven Hsu, Ryan J Tedford, Hideaki Senzaki
BACKGROUND: An accurate assessment of intrinsic right ventricular (RV) contractility and its relation to pulmonary arterial load is essential for the management of pulmonary hypertension. The pressure-volume relationship with load manipulation is the gold standard assessment used for this purpose, but its clinical application has been hindered by the lack of a single-beat method that is valid for the human RV. In the present study, we sought to validate a novel single-beat method to estimate the preload recruitable stroke work (PRSW) and its derivative for ventriculoarterial coupling in the human RV...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29734420/the-complementary-effect-of-cholesterol-and-vitamin-e-preloaded-in-cyclodextrins-on-frozen-bovine-semen-motility-parameters-membrane-integrity-and-lipid-peroxidation
#16
A Khellouf, K Benhenia, S Fatami, M Iguer-Ouada
BACKGROUND: During cryopreservation sperm cells suffer from two major deleterious impacts: oxidative stress and cold shock. OBJECTIVE: To investigate in bovine species the benefit of cholesterol and vitamin E, both loaded in cyclodextrins, as a double protection against oxidative stress and cold shock. MATERIALS AND METHODS: Semen was collected from nine mature bulls using an artificial vagina and each ejaculate was split into four equal aliquots...
March 2018: Cryo Letters
https://www.readbyqxmd.com/read/29728410/what-is-the-normal-haemodynamic-response-to-passive-leg-raise-a-study-of-healthy-volunteers
#17
Mohammed H Elwan, Ashraf Roshdy, Joseph A Reynolds, Eman M Elsharkawy, Salah M Eltahan, Timothy J Coats
OBJECTIVE: Passive leg raise (PLR) is used as self-fluid challenge to optimise fluid therapy by predicting preload responsiveness. However, there remains uncertainty around the normal haemodynamic response to PLR with resulting difficulties in application and interpretation in emergency care. We aim to define the haemodynamic responses to PLR in spontaneously breathing volunteers using a non-invasive cardiac output monitor, thoracic electrical bioimpedance, TEB (PLR-TEB). METHODS: We recruited healthy volunteers aged 18 or above...
May 4, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29727215/acute-stimulation-of-the-soluble-guanylate-cyclase-does-not-impact-on-left-ventricular-capacitance-in-normal-and-hypertrophied-porcine-hearts-in-vivo
#18
Alessio Alogna, Michael Schwarzl, Martin Manninger, Nazha Hamdani, Birgit Zirngast, Benjamin Kloth, Paul Steendijk, Jochen Verderber, David Zweiker, Dirk Westermann, Stefan Blankenberg, Heinrich Maechler, Carsten Tschöpe, Wolfgang A Linke, Gunther Marsche, Burkert M Pieske, Heiner Post
Experimental data indicate that stimulation of the nitric oxide (NO) - soluble guanylate cyclase (sGC) - cyclic guanosine monophosphate (cGMP) - protein kinase G (PKG) pathway can increase left ventricular (LV) capacitance via phosphorylation of the myofilamental protein titin. We aimed to test whether acute pharmacological sGC stimulation with BAY 41-8543 would increase LV capacitance via titin phosphorylation in healthy and deoxycorticosteroneacetate (DOCA)-induced hypertensive pigs. Nine healthy, landrace pigs and seven pigs with DOCA-induced hypertension and LV concentric hypertrophy were acutely instrumented to measure LV end-diastolic pressure-volume-relationships (EDPVR) at baseline and during intravenous infusion of BAY 41-8543 (1 and 3 μg/kg/min for 30 min, respectively)...
May 4, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29723878/biomechanical-comparison-between-preloaded-position-screw-and-lag-screw-fixations-for-their-compressive-effects-in-a-porcine-rib-fracture-model
#19
Ya-Pei Chang, Chi-Yuan Ho, Chao-Chang Chen, Lih-Seng Yeh
OBJECTIVES:  The aim of this study was to compare the compressive effect between preloaded position screws and lag screws in fracture fixation. METHODS:  Pairs of semi-cylindrical bone fragments were created on a porcine rib model to simulate fractured bones. The compressive forces of fracture fixation generated by preloaded position screws (P group) and conventional lag screws (L group) were recorded by a film stress sensor. In the P group, a pair of Angus bone holding forceps was used to compress the interfragmentary interface until reaching the preloading force of 1...
May 3, 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29723443/does-dapagliflozin-affect-energy-intake-and-appetite-a-randomized-controlled-exploratory-study-in-healthy-subjects
#20
Elizabeth Bertran, Helen D Berlie, Aaron Nixon, Linda Jaber
The primary aims of this study were to assess the effects of dapagliflozin versus placebo on energy intake and appetite ratings in healthy individuals. This was a randomized, single-blind, placebo-controlled, 2-period crossover study. In each period, healthy individuals received either dapagliflozin or placebo for 2 weeks. On assessment days, participants were asked to consume a standard preload breakfast. Appetite ratings were measured with 100-mm visual analog scales immediately before and during the 4.25-hour period after breakfast...
May 3, 2018: Clinical Pharmacology in Drug Development
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