keyword
MENU ▼
Read by QxMD icon Read
search

Hemorrhagic transformation

keyword
https://www.readbyqxmd.com/read/29663853/collateral-pial-circulation-relates-to-the-degree-of-brain-edema-on-ct-24-hours-after-ischemic-stroke
#1
Orlando Galego, Joana Jesus-Ribeiro, Mariana Baptista, João Sargento-Freitas, Ana Inês Martins, Fernando Silva, Gustavo Cordeiro Santos, Luís Cunha, César Nunes, Egídio Machado
Background Cerebral edema is frequent in patients with acute ischemic stroke (AIS) who undergo reperfusion therapy and is associated with high mortality. The impact of collateral pial circulation (CPC) status on the development of edema has not yet been determined. Methods We studied consecutive patients with AIS and documented M1-middle cerebral artery (MCA) and/or distal internal carotid artery (ICA) occlusion who underwent reperfusion treatment. Edema was graded on the 24-hour non-contrast computed tomography (NCCT) scan...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29651748/improved-reperfusion-and-vasculoprotection-by-the-poly-adp-ribose-polymerase-inhibitor-pj34-after-stroke-and-thrombolysis-in-mice
#2
Mohamad El Amki, Dominique Lerouet, Marie Garraud, Fei Teng, Virginie Beray-Berthat, Bérard Coqueran, Benoît Barsacq, Charlotte Abbou, Bruno Palmier, Catherine Marchand-Leroux, Isabelle Margaill
Benefits from thrombolysis with recombinant tissue plasminogen activator (rt-PA) after ischemic stroke remain limited due to a narrow therapeutic window, low reperfusion rates, and increased risk of hemorrhagic transformations (HT). Experimental data showed that rt-PA enhances the post-ischemic activation of poly(ADP-ribose)polymerase (PARP) which in turn contributes to blood-brain barrier injury. The aim of the present study was to evaluate whether PJ34, a potent PARP inhibitor, improves poor reperfusion induced by delayed rt-PA administration, exerts vasculoprotective effects, and finally increases the therapeutic window of rt-PA...
April 12, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29628946/a-prospective-multicenter-trial-of-the-transform-occlusion-balloon-catheter-trial-design-and-results
#3
M Asif Taqi, Syed A Quadri, Ajit S Puri, Brian F Fitzsimmons, Jianhua Nancy Jin, Ansaar T Rai, Curtis A Given, Javier Masso, Ciaran J Powers, Joey D English, Osama O Zaidat
Background and Purpose: Adjunctive treatments like balloon-assisted coil embolization (BACE) and stent-assisted coil embolization play a major role in the treatment of wide-neck and large intracranial aneurysms. The TransForm™ Occlusion Balloon Catheter (TOBC) registry is intended to evaluate the safety, efficacy, and efficiency of BACE using the TOBC. Method and Study Design: The TOBC registry is a prospective multicenter registry trial. Seven sites in the USA and 1 site in Spain participated and enrolled 81 patients...
February 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29622432/sirtuin-5-as-a-novel-target-to-blunt-blood-brain-barrier-damage-induced-by-cerebral-ischemia-reperfusion-injury
#4
Candela Diaz-Cañestro, Mario Merlini, Nicole R Bonetti, Luca Liberale, Patricia Wüst, Sylvie Briand-Schumacher, Jan Klohs, Sara Costantino, Melroy Miranda, Gabriele Schoedon-Geiser, Gerd A Kullak-Ublick, Alexander Akhmedov, Francesco Paneni, Jürg H Beer, Thomas F Lüscher, Giovanni G Camici
BACKGROUND: In acute ischemic stroke (AIS) patients, impaired blood-brain barrier (BBB) integrity is associated with hemorrhagic transformation and worsened outcome. Yet, the mechanisms underlying these relationships are poorly understood and consequently therapeutic strategies are lacking. This study sought to determine whether SIRT5 contributes to BBB damage following I/R brain injury. METHODS AND RESULTS: SIRT5 knockout (SIRT5-/- ) and wild type (WT) mice underwent transient middle cerebral artery (MCA) occlusion (tMCAO) followed by 48h of reperfusion...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29620649/primary-medullary-hemorrhage-in-a-patient-with-coagulopathy-due-to-alcoholic-cirrhosis-a-case-report
#5
Guangxun Shen, Yu Gao, Kwee-Yum Lee, Guangxian Nan
RATIONALE: Mild-to-moderate alcoholic cirrhosis of the liver is related to spontaneous intracerebral hemorrhage (ICH). In terms of spontaneous brainstem hemorrhage, pontine is considered as the most common site in contrast to medulla oblongata where the hemorrhage is rarely seen. This rare primary medullary hemorrhage has been attributed so far to vascular malformation (VM), anticoagulants, hypertension, hemorrhagic transformation, and other undetermined factors. PATIENT CONCERNS: Herein, we describe a 53-year-old patient with 35-year history of alcohol abuse was admitted for acute-onset isolated hemianesthesia on the right side...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29617457/sur1-trpm4-channel-activation-and-phasic-secretion-of-mmp-9-induced-by-tpa-in-brain-endothelial-cells
#6
Volodymyr Gerzanich, Min Seong Kwon, Seung Kyoon Woo, Alexander Ivanov, J Marc Simard
BACKGROUND: Hemorrhagic transformation is a major complication of ischemic stroke, is linked to matrix metalloproteinase-9 (MMP-9), and is exacerbated by tissue plasminogen activator (tPA). Cerebral ischemia/reperfusion is characterized by SUR1-TRPM4 (sulfonylurea receptor 1-transient receptor potential melastatin 4) channel upregulation in microvascular endothelium. In humans and rodents with cerebral ischemia/reperfusion (I/R), the SUR1 antagonist, glibenclamide, reduces hemorrhagic transformation and plasma MMP-9, but the mechanism is unknown...
2018: PloS One
https://www.readbyqxmd.com/read/29615979/landscape-of-molecular-events-in-pituitary-apoplexy
#7
REVIEW
Prakamya Gupta, Pinaki Dutta
Apoplectic pituitary adenomas cause significant morbidity and even mortality. The pituitary apoplexy denotes a pituitary adenoma presenting with hemorrhage and/or infarction, implementation in remedial effects of various of drugs in pituitary apoplexy is a promising pharmacogenomic field in the near future adenoma treatment. Indisputably, this is an important horizon for complicated pituitary adenomas. In a pituitary adenoma, the interplay between genetic, cytokine, and growth factors promotes the pathogenic transformation into an apoplectic formation...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29611066/application-of-wavelet-analysis-to-detect-dysfunction-in-cerebral-blood-flow-autoregulation-during-experimental-hyperhomocysteinaemia
#8
Valery V Aleksandrin, Alexander V Ivanov, Edward D Virus, Polina O Bulgakova, Aslan A Kubatiev
The purpose of the present study was to investigate the use of laser Doppler flowmetry (LDF) signals coupled with spectral wavelet analysis to detect endothelial link dysfunction in the autoregulation of cerebral blood flow in the setting of hyperhomocysteinaemia (HHcy). Fifty-one rats were assigned to three groups (intact, control, and HHcy) according to the results of biochemical assays of homocysteine level in blood plasma. LDF signals on the rat brain were recorded by LAKK-02 device to measure the microcirculatory blood flow...
April 3, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29606600/growth-advantage-of-escherichia-coli-o104-h4-strains-on-5-n-acetyl-9-o-acetyl-neuraminic-acid-as-a-carbon-source-is-dependent-on-heterogeneous-phage-borne-nans-p-esterases
#9
Nadja Saile, Lisa Schwarz, Kristina Eißenberger, Jochen Klumpp, Florian W Fricke, Herbert Schmidt
Enterohemorrhagic E. coli (EHEC) are serious bacterial pathogens which are able to cause a hemorrhagic colitis or the life-threatening hemolytic-uremic syndrome (HUS) in humans. EHEC strains can carry different numbers of phage-borne nanS-p alleles that are responsible for acetic acid release from mucin from bovine submaxillary gland and 5-N-acetyl-9-O-acetyl neuraminic acid (Neu5,9Ac2 ), a carbohydrate present in mucin. Thus, Neu5,9Ac2 can be transformed to 5-N-acetyl neuraminic acid, an energy source used by E...
March 26, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29598905/the-accuracy-of-serum-matrix-metalloproteinase-9-for-predicting-hemorrhagic-transformation-after-acute-ischemic-stroke-a-systematic-review-and-meta-analysis
#10
Lu Wang, Chenchen Wei, Linghui Deng, Ziqiong Wang, Mengyuan Song, Yao Xiong, Ming Liu
BACKGROUND: Hemorrhagic transformation is a serious complication of acute ischemic stroke, which may cause detrimental outcomes and the delayed use of anticoagulation therapy. Early predicting and identifying the patients at high risk of hemorrhagic transformation before clinical deterioration occurrence become a research priority. OBJECTIVE: To study the value of plasma matrix metalloproteinase-9 predicting hemorrhagic transformation after ischemic stroke. METHODS: We searched PubMed, Ovid, Cochrane Library, and other 2 Chinese databases to identify literatures published up to September 2017 and performed meta-analysis by STATA (version 12...
March 26, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29587638/cerebral-microbleeds-shouldn-t-dictate-treatment-of-acute-stroke-a-retrospective-cohort-study-evaluating-risk-of-intracerebral-hemorrhage
#11
Martin A Chacon-Portillo, Rafael H Llinas, Elisabeth B Marsh
BACKGROUND: Intravenous tissue plasminogen activator (IV tPA) after acute ischemic stroke carries the risk of symptomatic intracerebral hemorrhage (sICH). Cerebral microbleeds (CMBs) may indicate increased risk of hemorrhage and can be seen on magnetic resonance imaging (MRI). In this study, we examined the association between CMBs and sICH, focusing on the predictive value of their presence, burden, and location. METHODS: Records from all patients presenting to two academic stroke centers with acute ischemic stroke treated with IV tPA over a 5-year period were retrospectively reviewed...
March 27, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29582945/-spontaneous-parenchymal-intracranial-hemorrhage-a-diagnostic-challenge
#12
Ruth Eliahou, Auriel Eitan, Moshe Gomori, Jacob Sosna, Asaf Honig
Non-traumatic intracranial hemorrhage (ICH) is a devastating event associated with a high rate of morbidity and mortality. Patient age, hemorrhage location, number of foci, and underlying diseases are important clues to the etiology. Non-contrast head CT, given its availability and high sensitivity in detecting blood products, is frequently the first tool to readily detect ICH; however, different types of hemorrhages may share a common appearance on CT and the optimal therapeutic approach varies depending on etiology...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29575385/transcranial-sonography-to-differentiate-primary-intracerebral-hemorrhage-from-cerebral-infarction-with-hemorrhagic-transformation
#13
Wolf-Dirk Niesen, Axel Schläger, Matthias Reinhard, Hannah Fuhrer
BACKGROUND AND PURPOSE: The differentiation of primary intracerebral hemorrhage (ICH) from parenchymal hemorrhagic transformation within an ischemic infarction (PHI) is crucial in order to adapt therapeutic measures. We hypothesized that a distinction of ICH and PHI can be made at bedside via transcranial gray-scale and perfusion sonography. METHODS: We prospectively included 14 patients with intracranial hemorrhage on admission imaging in this pilot study. Differentiation between ICH and PHI was made either by cerebral magnetic resonance imaging or follow-up computed tomography scan...
March 25, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29562586/correlation-between-antiplatelet-therapy-in-secondary-prevention-of-acute-cerebral-infarction-and-cerebral-microbleeds-a-susceptibility-weighted-imaging-swi-study
#14
Caiyun Jia, Ci Wei, Ming Hu, Jing Xu, Kun Niu, Chao Zhang, Peiyuan Lv, Ling Li, Yanhong Dong
OBJECTIVE: To investigate the clinical significance of antiplatelet aggregation therapy for patients diagnosed with acute cerebral infarction (ACI) complicated with the cerebral microbleeds (CMBs). METHODS: Thirty patients with ACI and 36 patients with intracerebral hemorrhage (ICH) were included in this research. Two groups, studied by susceptibility-weighted imaging (SWI), were compared in terms of the number, location, and severity of CMBs. Then, 30 cases of ACI patients were divided into CMBs sub-group and non-CMBs sub-group...
March 15, 2018: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29556174/apolipoprotein-e-mimetic-peptide-cog1410-promotes-autophagy-by-phosphorylating-gsk-3%C3%AE-in-early-brain-injury-following-experimental-subarachnoid-hemorrhage
#15
Xinshen Li, Jianhua Peng, Jinwei Pang, Yue Wu, Xueping Huang, Yong Li, Jian Zhou, Long Gu, Xiaochuan Sun, Ligang Chen, Michael P Vitek, Yong Jiang
COG1410, a mimetic peptide derived from the apolipoprotein E (apoE) receptor binding region, exerts positive effect on neurological deficits in early brain injury (EBI) after experimental subarachnoid hemorrhage (SAH). Currently the neuroprotective effect of COG1410 includes inhibiting BBB disruption, reducing neuronal apoptosis, and neuroinflammation. However, the effect and mechanism of COG1410 to subcellular organelles disorder have not been fully investigated. As the main pathway for recycling long-lived proteins and damaged organelles, neuronal autophagy is activated in SAH and exhibits neuroprotective effects by reducing the insults of EBI...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29543140/imaging-selection-for-acute-stroke-intervention
#16
Bruce Cv Campbell, Mark W Parsons
This review summarizes the current state of knowledge regarding the use of imaging to guide stroke treatment. Brain imaging plays a central role in the diagnosis of stroke and identification of the mechanism of stroke, which is relevant to acute treatment, prognosis, and secondary prevention. The chief potential modalities are computed tomography (CT) and magnetic resonance imaging (MRI). Currently, most imaging occurs in hospital but mobile stroke units have expanded CT brain imaging into the prehospital field...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/29535893/temporal-changes-in-care-processes-and-outcomes-for-endovascular-treatment-of-acute-ischemic-stroke-retrospective-registry-data-from-three-korean-centers
#17
Jin Soo Lee, Seong-Joon Lee, Ji Man Hong, Jin Wook Choi, Jeong-Ho Hong, Hyuk-Won Chang, Chang-Hyun Kim, Yong-Won Kim, Dong-Hun Kang, Yong-Sun Kim, Bruce Ovbiagele, Andrew M Demchuk, Yang-Ha Hwang, Sung-Il Sohn
Background and Purpose: The purpose of the current study is to evaluate the influence of temporal patterns related to the availability of new endovascular treatment (EVT) devices on care processes and outcomes among patients with AIS. Materials and Methods: We enrolled 720 consecutive patients (January 2011 to May 2016) in a retrospective registry, ASIAN KR, from three Korean hospitals, who received EVT for acute ischemic stroke (AIS) caused by cervicocephalic arterial occlusions...
March 2018: Neurointervention
https://www.readbyqxmd.com/read/29532758/platelet-derived-exosomes-affect-the-proliferation-and-migration-of-human-umbilical-vein-endothelial-cells-via-mir-126
#18
Yan Sun, Xiao-Li Liu, Dai Zhang, Fang Liu, Yu-Jing Cheng, Yue Ma, Yu-Jie Zhou, Ying-Xin Zhao
BACKGROUND: Intraplaque angiogenesis, the process of generating new blood vessels mediated by endothelial cells, contributes to plaque growth, intraplaque hemorrhage, and thromboembolic events. Platelet-derived exosomes (PLT-EXOs) affect angiogenesis in multiple ways. The ability of miR-126, one of the best-characterized miRNAs that regulates angiogenesis, carried by PLT-EXOs to influence angiogenesis via the regulation of the proliferation and migration of endothelial cells is unknown...
March 13, 2018: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29526127/-radiological-forms-of-cerebral-amyloid-angiopathy
#19
Sándor Csizmadia, Erika Vörös
Cerebral amyloid angiopathy (CAA) is most commonly recognized by β-amyloid deposition in the small and medium sized vessels of the brain. The 71-year-old female presented with a sudden onset of vertigo and headache. By native computer tomography (CT) examination we found cerebral atrophy and the sign of chronic vascular injury. The complaints of the patient worsened, thus magnetic resonance imaging (MRI) was performed. The MRI scan revealed a bleeding transformation of an ischemic lesion in the right occipital region...
March 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29514614/novel-hemostatic-biomolecules-based-on-elastin-like-polypeptides-and-the-self-assembling-peptide-rada-16
#20
Shasha Yang, Sili Wei, Yun Mao, Hanxue Zheng, Juantao Feng, Jihong Cui, Xin Xie, Fulin Chen, Honmgmin Li
BACKGROUND: Safe and effective hemostatic materials are important for reducing mortality resulting from excessive hemorrhage. In this work, new biomaterials with hemostatic effects were created by fusing the gene coding for RADA-16, a self-assembling peptide with the sequence RADARADARADARADA, to the 3'-end of the open reading frame (ORF) encoding elastin-like polypeptides through gene recombination. RESULTS: The fusion proteins, termed 36R, 60R and 96R, were solubly over-expressed in Escherichia coli BL21 (DE3) based on genetic manipulation of the high-efficiency prokaryotic expression vector pET28a (+) and bacterial transformation...
March 7, 2018: BMC Biotechnology
keyword
keyword
62939
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"