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Amikacin hemodialysis

Céline Pouzot-Nevoret, Mathieu Magnin, Jean-Yves Ayoub, Laurent Bourguignon, Pascal Maire, Damien Wertz, Isabelle Goy-Thollot, Anthony Barthélemy, Emmanuel Boselli, Bernard Allaouchiche, Jeanne Marie Bonnet-Garin
Changes in pharmacokinetic parameters of critically ill patients make the treatment of infections challenging, particularly when multidrug-resistant bacteria are involved. The aim of this study was to evaluate the ability of haemodialysis to reduce the exposure to high dose amikacin and prevent nephrotoxicity. Amikacin 50 mg/kg was administered intravenously to six adult sheep once-daily for four days. The sheep were divided into two groups according to the implementation (group 1) or not (group 2) of haemodialysis...
August 2017: International Journal of Antimicrobial Agents
Alison Merkel, Cassandra Bellamy, Dan Negoianu, Christina Candeloro
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Hassan Al-Jafar, Anas Al-Yousef, Somaya Al-Shatti, Khalifa Al-Banwan
Heparin-induced thrombocytopenia (HIT) is a type of drug-induced immune thrombocytopenia (DITP). DITP is a rare and challenging clinical issue, especially when it is associated with thrombosis. A 62-year-old woman was admitted to our institution with end-stage renal failure. She received heparin for hemodialysis. Six days later, she became febrile and was treated with vancomycin and amikacin antibiotics. Two days after starting the vancomycin, she developed severe thrombocytopenia with extensive gangrenous deep vein thrombosis in her right leg, which required a below-the-knee amputation...
May 2015: Case Reports in Nephrology and Dialysis
M Hamouda, S Aloui, H Skhiri, A Letaif, M A Frih, N Ben Dhia, M Elmay
INTRODUCTION: Emphysematous pyelonephritis (EP) is an uncommon acute infection characterized by the presence of gas in the renal parenchyma. It is extremely rare in hemodialysis (HD) patients and diabetics account for most cases. It is a rapidly progressive and life threatening infection with a high mortality rate. We report a case of emphysematous pyelonephritis in a HD patient who was treated successfully with radical nephrectomy and antibiotic therapy. CASE REPORT: A 46-year-old diabetic male with end stage renal disease (ESRD) secondary to diabetic nephropathy and on maintenance HD for the last five years presented with a two weeks history of fever and loin pain...
May 2014: Arab Journal of Nephrology and Transplantation
Simon W Lam, Seth R Bauer
INTRODUCTION: Little is known about the pharmacokinetics of amikacin during continuous renal replacement therapy. METHODS: This prospective observational study included patients admitted to an academic medical center who received amikacin therapy while on continuous veno-venous hemodialysis (CVVHD) and had at least two serum sample concentrations measured after first-dose administration. First-order pharmacokinetic parameters, patient characteristics, and CVVHD parameters were recorded...
December 2013: Infectious Diseases and Therapy
Anwar Hamade, Agnieszka Pozdzik, O Denis, Monika Tooulou, Caroline Keyzer, F Jacobs, Jose Khabbout, Joëlle L Nortier
Mycobacterium fortuitum is a ubiquitous, rapidly growing nontuberculous mycobacterium (NTM). It is the most commonly reported NTM in peritoneal dialysis (PD) associated peritonitis. We report a case of a 52-year-old man on PD, who developed refractory polymicrobial peritonitis necessitating PD catheter removal and shift to hemodialysis. Thereafter, M. fortuitum was identified in the PD catheter culture and in successive cultures of initial peritoneal effluent and patient was treated with amikacin and ciprofloxacin for six months with a good and sustained clinical response...
2014: Case Reports in Nephrology
Wei Ren, Huixuan Pan, Peng Wang, Lei Lan, Wei Chen, Yan Wang, Lijun Ni, Li Peng
The present study aimed to investigate the pathogen distribution and drug resistance of lung infections in hemodialysis to guide clinical empirical pharmacy. The clinical data of 116 hemodialysis patients with pulmonary infection were analyzed. The majority of the 82 pathogens isolated from the sputa of patients were Gram-negative bacteria (accounting for 71.95%). The results of the drug sensitivity test suggested that Gram-negative bacilli had low resistance rates to piperacillin and tazobactam, imipenem and amikacin, while Gram-positive cocci had a low resistance rate to vancomycin...
June 2014: Experimental and Therapeutic Medicine
Małgorzata Gomółka, Katarzyna Szamotulska, Aleksandra Rymarz, Dorota Brodowska-Kania, Ivana Dubchak, Wiesław Piechota, Dariusz Jurkiewicz, Stanisław Niemczyk
UNLABELLED: The aim of the study was to asses safe and effective amikacin (AMK) doses in patients with different stages of chronic kidney disease. MATERIAL AND METHODS: The study included 25 patients, among them was 12 (48%) men and 13 (52%) women, aged 73.1 +/- 11.9 (38-89) years. AMK was applied in intravenous infusion during 10 days. The dosage was dependent on the stage of chronic kidney disease (CKD). Patients in stage 3A CKD (GFR 59--40 ml/min/1.73 m2) received 7...
April 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Jean Félix Piñerúa Gonsálvez, Rosanna del Carmen Zambrano Infantinot, Carlos Calcaño, César Montaño, Zaida Fuenmayor, Henry Rodney, Marianela Rodney
Rhizobium radiobacter is a Gram-negative, nitrogen-fixing bacterium, which is found mainly on the ground. It rarely causes infections in humans. It has been associated with bacteremia, secondary to colonization of intravascular catheters, in immunocompromised patients. The aim of this paper was to report the case of an infective endocarditis caused by R. radiobacter, in a 47-year-old male, diagnosed with chronic kidney disease stage 5, on replacement therapy with hemodialysis and who attended the medical center with fever of two weeks duration...
March 2013: Investigación Clínica
Yassamine Bentata, Intissar Haddiya, Nabila Ismailli, Adnane Benzirare, Omar Elmahi, Abderrahim Azzouzi
INTRODUCTION: Hemodialysis (HD) patients are predisposed to infective endocarditis (IE) mainly due to repeated manipulation of the vascular access. However, catheter seeding and IE may also result from a distant infection site. CASE SERIES: A diabetic patient who was maintained on regular HD through a permanent catheter in the right internal jugular vein presented with septicemia of urinary origin due to Pseudomonas aeruginosa. He was treated with injectable antibiotics for 15 days...
May 2013: Arab Journal of Nephrology and Transplantation
Weisheng Peng, Qiaoling Zhou, Xiang Ao, Rong Tang, Xiaozhao Li
OBJECTIVE: To investigate the pathogens and their resistance in continuous ambulatory peritoneal dialysis (CAPD) related peritonitis. METHODS: A total of 78 cases with CAPD related peritonitis from Xiangya Hospital between January 2007 and January 2011 were reviewed. Pathogens, resistance and outcomes of the 78 cases CAPD related peritonitis were analyzed retrospectively. RESULTS: Among them, 53 cases cultured positive (66.67%), 3 of which were combined infection and 2 strains were cultured...
December 2012: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Heino Stass, Kevin Corkery, Dennis Gribben, Michael A Eldon
UNLABELLED: Abstract Background: BAY41-6551, a drug-device combination in development for adjunctive treatment of Gram-negative pneumonia in mechanically ventilated patients, consists of amikacin formulated for inhalation coupled with the Pulmonary Drug Delivery System (PDDS) Clinical aerosol delivery platform. This study evaluated safety, tolerability, and pharmacokinetics (PK) of BAY41-6551 in subjects with chronic kidney disease (CKD). METHODS: Single doses of BAY41-6551 (400 mg amikacin) were administered using the PDDS Clinical handheld device to six subjects with mild-to-moderate (Group 1) and six subjects with severe renal impairment (Group 2)...
August 2011: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Ali Akbar Beigi, Sahar Khansoltani, Hassan Masoudpour, Abdol Amir Atapour, Afrooz Eshaghian, Elham Fatemeh Khademi
Infection of permanent catheters (Permcath) in hemodialysis (HD) patients can lead to catheter removal. The successful use of an antibiotic-lock to treat infection has reported good results in the treatment of catheters' infections. This study was designed to evaluate the impact of the intraluminal vancomycin in comparison with intravenous antibiotic administration. We included 67 (37 males and 30 females) chronic HD patients requiring Permcath insertion at our tertiary care hospital from July 2004 to June 2007...
January 2010: Saudi Journal of Kidney Diseases and Transplantation
C-L Lang, C-K Chiang, K-Y Hung, K-D Wu
Gram-negative pathogen-induced continuous ambulatory peritoneal dialysis- (CAPD) related peritonitis is increasing, especially that caused by enteric pathogens. We describe a 54-year-old Taiwanese man with a case of Campylobacter jejuni-mediated CAPD-related peritonitis and bacteremia. Positive Campylobacter jejuni dialysate and blood cultures confirmed the diagnosis of CAPD-mediated systemic infection. We initially administered intraperitoneal ceftazidime, amikacin and oral azithromycin, but the patient did not recover...
January 2009: Clinical Nephrology
Chih-Cheng Lai, Che-Kim Tan, Chung-Chih Chen, Po-Ren Hsueh
Mycobacterium neoaurum, a member of the Mycobacterium parafortuitum complex, has only rarely been reported as a pathogen of human infections. We report a case of catheter-related bloodstream infection (CRBSI) due to M. neoaurum in a patient on hemodialysis. The isolate was identified by conventional methods as well as by 16S rRNA gene analysis. The patient was successfully treated with intravenous antibiotics (meropenem and amikacin) for three weeks and the catheter was removed. M. neoaurum should be considered as a possible cause of CRBSI in patients with renal failure...
September 2009: International Journal of Infectious Diseases: IJID
Hasan Naz, Garip Sahin, Servet Serbest, Ahmet Uğur Yalçin
One of the leading problems encountered in patients undergoing peritoneal dialysis is infectious complications including peritonitis. We aimed to investigate the etiology, clinical presentation and therapy of peritonitis attacks in patients undergoing peritoneal dialysis (PD) in two ultimate hospitals in Eskisehir (located at middle Anatolia region of Turkey) over seven years. We determined 179 peritonitis attacks in 74 (62.2%) of 119 patients undergoing PD. The average annual peritonitis incidence in PD patients was found as 0...
April 2008: Mikrobiyoloji Bülteni
Anil K Saxena, B R Panhotra, Mohammed Naguib, D S Sundaram, C K Venkateshhappa, Wahid Uzzaman, Khalifa Al-Mulhim
A good vascular access is the lifeline of patients on long-term hemodialysis (HD) and anteriovenous fistula is considered the ideal access. Vascular access related septicemia (VARS) is the second most common cause of mortality among HD patients. Such infections could also lead to loss of vascular access unless specific measures are taken to preserve the accesses. The present study was designed to determine the incidence of septicemia, common bacterial flora involved, and impact of early, empirical antibiotic therapy on vascular access salvage among HD patients...
January 2002: Saudi Journal of Kidney Diseases and Transplantation
L Linares, C Cervera, F Cofán, M J Ricart, N Esforzado, V Torregrosa, F Oppenheimer, J M Campistol, F Marco, A Moreno
BACKGROUND: Mutiresistant bacterial infections are an emerging problem in the nosocomial setting. Our objectives were to describe the incidence, outcome, and risk factors for acquisition of multiresistant bacteria among renal transplant recipients. METHODS: We prospectively followed patients undergoing kidney transplantation over a 3-year period. We collected demographic features, underlying chronic diseases, and main transplant characteristics and complications...
September 2007: Transplantation Proceedings
Suzan Sanavi, Ahad Ghods, Reza Afshar
Hemodialysis catheter related infections (HCRI) are one of the major causes of increasing mortality, morbidity and cost of therapy in hemodialysis patients. Prevention of HCRI requires the identification of predisposing risk factors. To determine the frequency of HCRI risk factors, we studied 116 patients (54% male, mean age of 49.5+/-16 years) patients with HCRI between 2003-2004. Forty one percent of the patients were diabetic. There was a history of previous catheter placement and infection in 41% and 32% of patients, respectively...
March 2007: Saudi Journal of Kidney Diseases and Transplantation
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