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https://www.readbyqxmd.com/read/28196997/validation-of-hindi-version-of-stages-of-recovery-instrument
#1
Sandeep Grover, Neha Singla, Ajit Avasthi
OBJECTIVES: To translate the Stages of Recovery Instrument (STORI) and evaluate its psychometric properties, demographic, and clinical correlates among patients with schizophrenia. MATERIALS AND METHODS: The English version of the scale was translated into Hindi using the World Health Organization methodology. The Hindi version was completed by thirty patients with schizophrenia on two occasions, 4-7 days apart. Another thirty patients completed both Hindi and English version within a gap of 4-7 days...
October 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28196359/language-on-the-phenomenology-of-linguistic-experience-in-schizophrenia-ancillary-article-to-eawe-domain-4
#2
Elizabeth Pienkos, Louis Sass
Anomalies of language use and comprehension are common in schizophrenia. However, they are typically studied only from a diagnostic or behavioral perspective and viewed simply as deficits or disruptions of normal functioning. Such approaches ignore what it is like to experience language, and thus are at risk of missing aspects of these linguistic anomalies that may be crucial for understanding them. The Examination of Anomalous World Experience (EAWE) provides one way to inquire into the experiential changes related to and underlying these disturbances...
February 15, 2017: Psychopathology
https://www.readbyqxmd.com/read/28187965/impact-of-rtms-on-functional-connectivity-within-the-language-network-in-schizophrenia-patients-with-auditory-hallucinations
#3
F Briend, E Leroux, N Delcroix, A Razafimandimby, O Etard, S Dollfus
This exploratory study investigated the functional connectivity (FC) in the language network in schizophrenia patients (SZ) with auditory verbal hallucinations (AVHs), and the therapeutic efficacy of rTMS on it. Eleven SZ with AVHs and 10 healthy controls (HC) underwent two fMRI sessions using a speech listening paradigm. SZ received 20Hz rTMS following the first fMRI session. Compared to HC, SZ showed a reduced FC in the language network. While AVHs improved after 12days, no changes in FC were observed. This suggests the efficacy of high-frequency rTMS on AVH without any impact for rTMS on FC within the language network...
February 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28178977/diagnostic-performance-and-optimal-cut-off-scores-of-the-massachusetts-youth-screening-instrument-second-version-in-a-sample-of-swiss-youths-in-welfare-and-juvenile-justice-institutions
#4
Claudia Dölitzsch, Laura E W Leenarts, Klaus Schmeck, Jorg M Fegert, Thomas Grisso, Marc Schmid
BACKGROUND: There is a growing consensus about the importance of mental health screening of youths in welfare and juvenile justice institutions. The Massachusetts Youth Screening Instrument-second version (MAYSI-2) was specifically designed, normed and validated to assist juvenile justice facilities in the United States of America (USA), in identifying youths with potential emotional or behavioral problems. However, it is not known if the USA norm-based cut-off scores can be used in Switzerland...
February 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28167432/comparison-of-psychopathological-dimensions-between-major-depressive-disorder-and-schizophrenia-spectrum-disorders-focusing-on-language-affectivity-and-motor-behavior
#5
Sarah Steinau, Katharina Stegmayer, Fabian U Lang, Markus Jäger, Werner Strik, Sebastian Walther
This study tested whether patients with major depressive disorder (MDD) and schizophrenia spectrum disorders would differ in three dimensions of psychopathology (language, affectivity and motor behavior) as assessed by the Bern Psychopathology Scale (BPS) in a cohort of 58 patients with MDD and 146 patients with schizophrenia spectrum disorders. The overall estimation of severity of each of the three dimensions was rated on a seven-point Likert scale from severely inhibited to severely disinhibited. Here, more than half of the patients endorsed ratings that showed normal or mildly (dis-)inhibited behavior...
January 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28146614/tardive-dyskinesia-prevalence-in-the-period-of-second-generation-antipsychotic-use-a-meta-analysis
#6
Maren Carbon, Cheng-Hsi Hsieh, John M Kane, Christoph U Correll
OBJECTIVE: Comparison of tardive dyskinesia (TD) prevalence during contemporaneous treatment with first-generation antipsychotics (FGAs) and/or second-generation antipsychotics (SGAs). DATA SOURCES: PubMed/MEDLINE/Google Scholar search (January 1, 2000-September 30, 2015) without language restriction using (tardive dyskinesia OR tardive) AND (antipsychotic*) plus specific names of SGAs. STUDY SELECTION: Of 8,895 hits, we screened 203 full-text articles for cross-sectional, rating scale-based TD rates during SGA, FGA, or FGA+SGA treatment...
January 31, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28131010/electrophysiological-basis-of-reading-related-phonological-impairment-in-chinese-speakers-with-schizophrenia-an-erp-study
#7
Jiuju Wang, Qi Liu, Taeko N Wydell, Jinmin Liao, Fang Wang, Wenxiang Quan, Ju Tian, Pengfei Wang, Jin Liu, Wentian Dong
It has been reported in alphabetic languages that individuals with schizophrenia showed language-related cognitive impairments including phonological deficits, which were in turn associated with clinical symptoms such as auditory hallucinations and thought disorders. To date, however, the phonological deficits involved in schizophrenia in Chinese and its neural basis have not been well established. In order to establish such a relationship we conducted a behavioral study using lexical tone judgment and digit span tasks as well as an event-related potential (ERP) study with an auditory oddball paradigm, in particular, for P300 effects, the event-related brain potential (ERP) index of discrimination...
January 11, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28130005/resting-state-functional-connectivity-in-medication-na%C3%A3-ve-schizophrenia-patients-with-and-without-auditory-verbal-hallucinations-a-preliminary-report
#8
Xiao Chang, Guusje Collin, Yibin Xi, Longbiao Cui, Lianne H Scholtens, Iris E Sommer, Huaning Wang, Hong Yin, René S Kahn, Martijn P van den Heuvel
Auditory verbal hallucinations (AVH) are a cardinal feature of schizophrenia that has been associated with activation in language processing areas, in concert with higher-order cognitive brain networks. It remains to be determined whether, and if so how, the functional dynamics between these brain regions contributes to the emergence of AVH. The current study recruited 36 first-episode medication-naïve schizophrenia patients, including 18 patients with AVH, 18 patients free of AVH and 18 controls matched on age, gender and level of education...
January 24, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28127520/aberrant-neural-networks-for-the-recognition-memory-of-socially-relevant-information-in-patients-with-schizophrenia
#9
Jooyoung Oh, Ji-Won Chun, Eunseong Kim, Hae-Jeong Park, Boreom Lee, Jae-Jin Kim
INTRODUCTION: Patients with schizophrenia exhibit several cognitive deficits, including memory impairment. Problems with recognition memory can hinder socially adaptive behavior. Previous investigations have suggested that altered activation of the frontotemporal area plays an important role in recognition memory impairment. However, the cerebral networks related to these deficits are not known. The aim of this study was to elucidate the brain networks required for recognizing socially relevant information in patients with schizophrenia performing an old-new recognition task...
January 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28126626/language-context-processing-deficits-in-schizophrenia-the-role-of-attentional-engagement
#10
Megan A Boudewyn, Cameron S Carter, Debra L Long, Matthew J Traxler, Tyler A Lesh, George R Mangun, Tamara Y Swaab
Individuals with schizophrenia exhibit problems in language comprehension that are most evident during discourse processing. We hypothesized that deficits in cognitive control contribute to these comprehension deficits during discourse processing, and investigated the underlying cognitive-neural mechanisms using EEG (alpha power) and ERPs (N400). N400 amplitudes to globally supported or unsupported target words near the end of stories were used to index sensitivity to previous context. ERPs showed reduced sensitivity to context in patients versus controls...
February 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28116777/pharmacological-treatment-for-antipsychotic-related-constipation
#11
REVIEW
Susanna Every-Palmer, Giles Newton-Howes, Mike J Clarke
BACKGROUND: Antipsychotic-related constipation is a common and serious adverse effect, especially for people taking clozapine. Clozapine has been shown to impede gastrointestinal motility, leading to constipation, and has been reported in up to 60% of patients receiving clozapine. In rare cases, complications can be fatal. Appropriate laxatives should be prescribed to treat constipation in people taking antipsychotics, but there is a lack of guidance on the comparative effectiveness and harms of different agents in this population...
January 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28095382/examination-of-anomalous-world-experience-a-report-on-reliability
#12
Joseph Conerty, Borut Skodlar, Elizabeth Pienkos, Tina Zadravek, Greg Byrom, Louis Sass
BACKGROUND: The EAWE (Examination of Anomalous World Experience) is a newly developed, semi-structured interview that aims to capture anomalies of subjectivity, common in schizophrenia spectrum disorders, that pertain to experiences of the lived world, including space, time, people, language, atmosphere, and certain existential attitudes. By contrast, previous empirical studies of subjective experience in schizophrenia have focused largely on disturbances in self-experience. AIM: To assess the reliability of the EAWE, including internal consistency and interrater reliability...
January 18, 2017: Psychopathology
https://www.readbyqxmd.com/read/28089135/phenotypic-continuum-between-autism-and-schizophrenia-evidence-from-the-movie-for-the-assessment-of-social-cognition-masc
#13
Gilles Martinez, Charlotte Alexandre, Célia Mam-Lam-Fook, Narjes Bendjemaa, Raphaël Gaillard, Patricia Garel, Isabel Dziobek, Isabelle Amado, Marie-Odile Krebs
Schizophrenic (SCZ) and autism (ASD) spectrum disorders share several features including social cognition impairments. In SCZ, the link between symptomatic dimensions and social cognition deficits remains unclear. The Movie for the Assessment of Social Cognition (MASC) test, available in several languages including English, investigates mental state attribution capabilities in complex interpersonal situations. After its translation into French, we used MASC to direct compare social cognition in 36 young participants with SCZ to 19 with ASD and 20 healthy controls (HC) matched for gender, age (18-25y...
January 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28081145/probing-the-association-between-early-evolutionary-markers-and-schizophrenia
#14
Saurabh Srinivasan, Francesco Bettella, Sahar Hassani, Yunpeng Wang, Aree Witoelar, Andrew J Schork, Wesley K Thompson, David A Collier, Rahul S Desikan, Ingrid Melle, Anders M Dale, Srdjan Djurovic, Ole A Andreassen
Schizophrenia is suggested to be a by-product of the evolution in humans, a compromise for our language, creative thinking and cognitive abilities, and thus, essentially, a human disorder. The time of its origin during the course of human evolution remains unclear. Here we investigate several markers of early human evolution and their relationship to the genetic risk of schizophrenia. We tested the schizophrenia evolutionary hypothesis by analyzing genome-wide association studies of schizophrenia and other human phenotypes in a statistical framework suited for polygenic architectures...
2017: PloS One
https://www.readbyqxmd.com/read/28032254/white-matter-correlates-of-the-disorganized-speech-dimension-in-schizophrenia
#15
Petra V Viher, Katharina Stegmayer, Stéphanie Giezendanner, Andrea Federspiel, Stephan Bohlhalter, Roland Wiest, Werner Strik, Sebastian Walther
Disorganized speech is related to functional abnormalities in schizophrenia. To test the association between formal thought disorders (FTDs) and white matter microstructure, we applied a behavioral rating and diffusion tensor imaging in 61 patients with schizophrenia spectrum disorders. The Bern Psychopathology Scale was used to rate the dimension of language abnormalities ranging from negative FTDs, basically unaltered speech, to positive FTDs. Tract-based spatial statistics indicated increased fractional anisotropy in left hemispheric pathways of the language system in patients with negative FTDs...
December 28, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28025777/brain-development-and-akt-signaling-the-crossroads-of-signaling-pathway-and-neurodevelopmental-diseases
#16
REVIEW
Long Wang, Kai Zhou, Zhi Fu, Di Yu, Hesuyuan Huang, Xiaodong Zang, Xuming Mo
Neurodevelopmental biology, coupled with the application of advanced histological, imaging, molecular, cellular, biochemical, and genetic approaches, has provided new insights into these intricate genetic, cellular, and molecular events. During telencephalic development, specific neural progenitor cells (NPCs) proliferate, differentiate into numerous cell types, migrate to their apposite positions, and form an integrated circuitry. Critical disturbance to this dynamic process via genetic and environmental risk can cause neurological disorders and disability...
December 26, 2016: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28024236/cerebral-blood-flow-and-its-connectivity-features-of-auditory-verbal-hallucinations-in-schizophrenia-a-perfusion-study
#17
Long-Biao Cui, Gang Chen, Zi-Liang Xu, Lin Liu, Hua-Ning Wang, Li Guo, Wen-Ming Liu, Ting-Ting Liu, Shun Qi, Kang Liu, Wei Qin, Jin-Bo Sun, Yi-Bin Xi, Hong Yin
The goal of the study was to investigate cerebral blood flow (CBF) and its connectivity (an across-subject covariance measure) patterns of schizophrenia (SZ) patients with auditory verbal hallucinations (AVHs). A total of demographically matched 25 SZ patients with AVHs, 25 without AVHs, and 25 healthy controls (HCs) underwent resting state perfusion imaging using a pulsed arterial spin labeling sequence. CBF and its connectivity were analyzed and then CBF topological properties were calculated. AVHs patients exhibited decreased CBF in the bilateral superior and middle frontal gyri and postcentral gyri, and right supplementary motor area compared with SZ patients without AVHs...
February 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28013441/pragmatic-competency-and-obsessive-compulsive-disorder-a-comparative-assessment-with-normal-controls
#18
Shima Ghahari, Hamidreza Hassani, Maryam Purmofrad
Unlike such cognitive impairments as autism and schizophrenia, the speech pattern in obsessive-compulsive disorder (OCD) has largely remained underrepresented. We examined the pragmatic competence of OCD-affected individuals under two variant modes: pragmatic recognition and pragmatic production. In the recognition phase, the informants completed a discourse completion test around two speech acts of request and apology (20 high power distance situations). The production phase was carried out through an interview during which the informants' communication behaviors were rated on the basis of the Orion's pragmatic language skills checklist (OPLS) subscales...
December 24, 2016: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/28012423/lateralization-of-intrinsic-frontoparietal-network-connectivity-and-symptoms-in-schizophrenia
#19
Shuraku Son, Jun Miyata, Yasuo Mori, Masanori Isobe, Shin-Ichi Urayama, Toshihiko Aso, Hidenao Fukuyama, Toshiya Murai, Hidehiko Takahashi
It has been frequently reported that schizophrenia patients have reduced functional lateralization in the areas related to language processing. Furthermore, there is evidence supporting that schizophrenia patients have disrupted functional connectivity in the bilateral frontoparietal networks (FPNs), of which the left is strongly associated with a cognition-language paradigm, using resting-state functional magnetic resonance imaging (rsfMRI). To examine the laterality of resting-state functional connectivity in schizophrenia, we investigated the bilateral FPNs...
February 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28010158/abnormalities-of-language-pathways-in-schizophrenia-patients-with-and-without-a-lifetime-history-of-auditory-verbal-hallucinations-a-dti-based-tractography-study
#20
Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: Auditory verbal hallucinations (AVHs) are frequently observed in patients with schizophrenia and could be the result of white matter (WM) fibre abnormalities involved in speech production/comprehension and perception. We evaluated WM integrity changes in schizophrenia with (SZ+) and without (SZ-) lifetime AVHs compared to healthy controls, using diffusion tensor imaging-based tractography, with a novel focus on the structural connectivity within both intra- and interhemispheric fasciculi...
December 23, 2016: World Journal of Biological Psychiatry
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