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https://www.readbyqxmd.com/read/28816925/treatment-of-diabetic-ketoacidosis-associated-with-antipsychotic-medication-literature-review
#1
Antonia Vuk, Maja Baretic, Martina Matovinovic Osvatic, Igor Filipcic, Nikolina Jovanovic, Martina Rojnic Kuzman
BACKGROUND: The second-generation antipsychotics (SGAs) are associated with metabolic disturbances. Diabetic ketoacidosis (DKA) is a rare, but potentially fatal sign of acute glucose metabolism dysregulation, which may be associated with the use of SGAs. This study aims to review published reports of patients with schizophrenia and antipsychotic drug-associated DKA, focusing on the effective management of both conditions. METHODS: Using a predefined search strategy, we searched PubMed and EMBASE from their inception to July 2016...
August 15, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28810347/-history-of-world-neurosurgery
#2
X Wang
In 5000 BC, South American tribes digged the bones in the living head to seek ways to communicate with the gods, which was primitive trephination and may be the first neurosurgical behavior. In 2600 BC, Imhotep in ancient Egypt took the brain out of the head from the nose, for a better preserve of the mummy, which was a prototype of modern transsphenoidal surgery. And the development of anatomy in ancient Greek laid a solid foundation for neurosurgery. From 500 to 1500 AD, the rise of religion and the occurrence of war, prompted a large number of craniocerebral trauma, which contributed greatly to the early development of neurosurgery as a distinct specialty...
May 28, 2017: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28789558/canadian-schizophrenia-guidelines-introduction-and-guideline-development-process
#3
Tamara Pringsheim, Donald Addington
INTRODUCTION: The aim of the Canadian Schizophrenia Guidelines is to provide evidence-based recommendations for the treatment of schizophrenia and schizophrenia spectrum disorders. The target users are health care professionals. Recommendations are provided as guidance to physicians and patients, with the goal of improving the overall standard of care of individuals with schizophrenia. METHODS: The guidelines were developed using the ADAPTE process, a systematic approach and alternative to de novo guideline development, in which an existing guideline is customised to suit the local context...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28777029/characterizing-smartphone-engagement-for-schizophrenia-results-of-a-naturalist-mobile-health-study
#4
John Torous, Patrick Staples, Linda Slaters, Jared Adams, Luis Sandoval, J P Onnela, Matcheri Keshavan
INTRODUCTION: Despite growing interest in smartphone apps for schizophrenia, little is known about how these apps are utilized in the real world. Understanding how app users are engaging with these tools outside of the confines of traditional clinical studies offers an important information on who is most likely to use apps and what type of data they are willing to share. METHODS: The Schizophrenia and Related Disorders Alliance of America, in partnership with Self Care Catalyst, has created a smartphone app for schizophrenia that is free and publically available on both Apple iTunes and Google Android Play stores...
August 4, 2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28772137/action-verb-fluency-deficits-in-schizophrenia-spectrum-disorders-linking-language-cognition-and-interpersonal-functioning
#5
Daria Smirnova, Melanie Clark, Assen Jablensky, Johanna C Badcock
Deficits in action (verb) fluency have previously been reported in schizophrenia spectrum disorders. The degree to which this reflects difficulties generating verbs in different semantic categories is unknown. Here, action fluency responses of 46 patients with schizophrenia spectrum disorders and 76 healthy controls were classified as action or mental state verbs, using well-established taxonomies. The word length, frequency, age of acquisition, valence and concreteness of the verbs produced were also examined...
July 25, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28758203/haloperidol-for-psychosis-induced-aggression-or-agitation-rapid-tranquillisation
#6
REVIEW
Edoardo G Ostinelli, Melanie J Brooke-Powney, Xue Li, Clive E Adams
BACKGROUND: Haloperidol used alone is recommended to help calm situations of aggression or agitation for people with psychosis. It is widely accessible and may be the only antipsychotic medication available in limited-resource areas. OBJECTIVES: To examine whether haloperidol alone is an effective treatment for psychosis-induced aggression or agitation, wherein clinicians are required to intervene to prevent harm to self and others. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Study-Based Register of Trials (26th May 2016)...
July 31, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28756686/beyond-diagnosis-the-core-sets-for-persons-with-schizophrenia-based-on-the-world-health-organization-s-international-classification-of-functioning-disability-and-health
#7
Juana Gómez-Benito, Georgina Guilera, Maite Barrios, Emilio Rojo, Oscar Pino, Arantxa Gorostiaga, Nekane Balluerka, María Dolores Hidalgo, José Luis Padilla, Isabel Benítez, Melissa Selb
PURPOSE: Based on the International Classification of Functioning, Disability and Health (ICF), this paper presents the results of the process to develop the Comprehensive and Brief Core Sets for schizophrenia that allow to comprehensively describe functioning in persons with schizophrenia. METHODS: Twenty health professionals from diverse backgrounds participated in a formal and iterative decision-making process during an international consensus conference to develop these Core Sets...
July 30, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28755877/multiple-retinal-anomalies-in-schizophrenia
#8
REVIEW
Selin A Adams, Henry A Nasrallah
INTRODUCTION: In addition to being a critical component of the visual system, the retina provides the opportunity for an accessible and noninvasive probe of brain pathology in neuropsychiatric disorders. Several studies have reported various retinal abnormalities in schizophrenia, some primary and others iatrogenic. There is now increasing evidence supporting the existence of retinal anomalies in schizophrenia across structural, neurochemical and physiological parameters. Here, we review the types of retinal pathology in schizophrenia and discuss how these findings may provide novel insights for future research into the neurodevelopmental neurobiology of this syndrome, and possibly as useful biomarkers...
July 26, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28748485/early-onset-first-episode-psychosis-dimensional-structure-of-symptoms-clinical-subtypes-and-related-neurodevelopmental-markers
#9
Maria Giuseppina Petruzzelli, Lucia Margari, Andrea Bosco, Francesco Craig, Roberto Palumbi, Francesco Margari
Despite the growing interest in a dimensional approach to the assessment of symptoms and clinically relevant phenomena in schizophrenia spectrum disorders, very few studies, to date, have examined the dimensional structure of symptoms in early onset first episode psychosis. In the present study, we assessed a sample of 60 children and adolescents of both sexes with first episode schizophrenia spectrum psychosis. A principal component analysis (PCA) of the Positive and Negative Syndrome Scale (PANSS) was performed and the factors obtained were used to carry out a cluster analysis...
July 26, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28735586/cognitive-development-prior-to-onset-of-psychosis
#10
J Mollon, A Reichenberg
Schizophrenia patients commonly exhibit substantial and diffuse cognitive impairment. Evidence suggests that subtle cognitive deficits are already apparent in childhood and adolescence, many years prior to onset of psychosis. While there is almost unequivocal evidence of some degree of cognitive impairment in individuals who later develop schizophrenia, the literature remains inconclusive regarding the exact nature of this impairment and warrants careful review and interpretation. Meta-analytic findings suggest that individuals who later develop schizophrenia, but not related disorders, such as bipolar disorder, exhibit a premorbid IQ deficit of around 8 points...
July 24, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28716789/identification-of-the-delivery-of-cognitive-behavioural-therapy-for-psychosis-cbtp-using-a-cross-sectional-sample-from-electronic-health-records-and-open-text-information-in-a-large-uk-based-mental-health-case-register
#11
Craig Colling, Lauren Evans, Matthew Broadbent, David Chandran, Thomas J Craig, Anna Kolliakou, Robert Stewart, Philippa A Garety
OBJECTIVE: Our primary objective was to identify cognitive behavioural therapy (CBT) delivery for people with psychosis (CBTp) using an automated method in a large electronic health record database. We also examined what proportion of service users with a diagnosis of psychosis were recorded as having received CBTp within their episode of care during defined time periods provided by early intervention or promoting recovery community services for people with psychosis, compared with published audits and whether demographic characteristics differentially predicted the receipt of CBTp...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28710941/procedural-learning-in-parkinson-s-disease-specific-language-impairment-dyslexia-schizophrenia-developmental-coordination-disorder-and-autism-spectrum-disorders-a-second-order-meta-analysis
#12
Gillian M Clark, Jarrad A G Lum
The serial reaction time task (SRTT) has been used to study procedural learning in clinical populations. In this report, second-order meta-analysis was used to investigate whether disorder type moderates performance on the SRTT. Using this approach to quantitatively summarise past research, it was tested whether autism spectrum disorder, developmental coordination disorder, dyslexia, Parkinson's disease, schizophrenia, and specific language impairment differentially affect procedural learning on the SRTT. The main analysis revealed disorder type moderated SRTT performance (p=0...
October 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28710677/cerebellar-contributions-to-persistent-auditory-verbal-hallucinations-in-patients-with-schizophrenia
#13
Maximilian Cierpka, Nadine D Wolf, Katharina M Kubera, Mike M Schmitgen, Nenad Vasic, Karel Frasch, Robert Christian Wolf
There is growing evidence that the cerebellum plays a crucial role in the pathophysiology of schizophrenia symptoms. Despite increasing evidence for cerebellar involvement in affective, attentive, and cognitive functions including language processing and perception, investigations of cerebellar contributions to auditory verbal hallucinations (AVH) in schizophrenia are lacking. Using structural magnetic resonance imaging at 3T, we investigated the data of 20 patients with schizophrenia and 14 matched healthy controls...
July 14, 2017: Cerebellum
https://www.readbyqxmd.com/read/28710394/altered-brain-network-connectivity-as-a-potential-endophenotype-of-schizophrenia
#14
Peng Li, Teng-Teng Fan, Rong-Jiang Zhao, Ying Han, Le Shi, Hong-Qiang Sun, Si-Jing Chen, Jie Shi, Xiao Lin, Lin Lu
Abnormal functional brain connectivity could be considered an endophenotype of psychosis in schizophrenia. Identifying candidate endophenotypes may serve as a tool for elucidating its biological and neural mechanisms. The present study investigated the similarities and differences of features of brain network connectivity between patients and their first-degree relatives. Independent component analysis was conducted on imaging data collected from 34 healthy controls, 33 schizophrenia patients, and 30 unaffected first-degree relatives...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693486/performance-of-international-medical-students-in-psychosocial-medicine
#15
D Huhn, J Lauter, D Roesch Ely, E Koch, A Möltner, W Herzog, F Resch, S C Herpertz, C Nikendei
BACKGROUND: Particularly at the beginning of their studies, international medical students face a number of language-related, social and intercultural challenges. Thus, they perform poorer than their local counterparts in written and oral examinations as well as in Objective Structured Clinical Examinations (OSCEs) in the fields of internal medicine and surgery. It is still unknown how international students perform in an OSCE in the field of psychosocial medicine compared to their local fellow students...
July 10, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28688740/reading-deficits-in-schizophrenia-and-their-relationship-to-developmental-dyslexia-a-review
#16
REVIEW
Veronica Whitford, Gillian A O'Driscoll, Debra Titone
Although schizophrenia and developmental dyslexia are considered distinct disorders in terms of clinical presentation and functional outcome, they both involve disruption in the processes that support skilled reading, including language, auditory perception, visual perception, oculomotor control, and executive function. Further, recent work has proposed a common neurodevelopmental basis for the two disorders, as suggested by genetic and pathophysiological overlap. Thus, these lines of research suggest that reading may be similarly impacted in schizophrenia and dyslexia...
July 5, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28686564/asperger-syndrome-and-schizophrenia-%C3%AE-eurodevelopmental-continuum-or-separated-clinical-entities
#17
Chr Anomitri, H Lazaratou
This article is an overview of the literature on Asperger's syndrome and schizophrenia and aim to discuss their similarities and differences. Eugen Bleuler who associated the terms "schizophrenia" and "autism" a century ago, viewed autism as a form of solitude of schizophrenic patients representing withdrawal from reality. Ever since, there has been confusion as to the boundaries between these conditions. Nowadays recent research, from a variety of perspectives-genomics, neurodevelopment, psychiatry, etc. has given new information on these conditions...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28672735/safety-concerns-associated-with-second-generation-antipsychotic-long-acting-injection-treatment-a-systematic-update
#18
Salvatore Gentile
Background It has been recently suggested that second-generation antipsychotic long-acting injection (SGA-LAIs) are underutilized in clinical practice, despite that their costs significantly impact on national health system budgets. Hence, an updated analysis of safety data shown by SGA-LAIs may contribute to clarify their role in clinical practice. Materials and methods English-language, peer-reviewed articles reporting updated, primary findings on the SGA-LAI safety were identified (updated through an electronic search of five databases - PubMed, EMBASE, PsycInfo, DARE and the Cochrane Library)...
June 23, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28669318/fronto-subcortical-functional-connectivity-in-patients-with-schizophrenia-and-bipolar-disorder-during-a-verbal-fluency-task
#19
Anaïs Vandevelde, Elise Leroux, Nicolas Delcroix, Sonia Dollfus
OBJECTIVES: Impairments in language production are common of schizophrenia (SZ) and bipolar disorder (BD). Identifying distinct functional connectivity (FC) patterns in SZ and BD may provide biomarkers for their diagnoses. METHODS: 49 participants (15 SZ, 14 BD, and 20 HC) underwent a verbal fluency task consisting of mentally generating verbs in French, alternated with periods of silence. Functional network allowed identifying activation clusters: the medio-frontal cluster (MFC), the left subcortical cluster (LSCC) and the left fronto-lateral cluster (LFLC)...
July 3, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28661580/a-review-of-endophenotypes-in-schizophrenia-and-autism-the-next-phase-for-understanding-genetic-etiologies
#20
Lisabeth F DiLalla, Megan McCrary, Emma Diaz
Many psychiatric disorders are caused by multiple genes and multiple environmental factors, making the identification of specific genetic risk factors for these disorders difficult. Endophenotypes are behaviors or characteristics that are intermediate between the genotype and a phenotype of interest. Because they are more directly related to the gene action than is the endpoint disorder, they may be useful in the identification of specific genes related to psychiatric disorders and the classification of disorders or traits that share an underlying genetic etiology...
June 29, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
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