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https://www.readbyqxmd.com/read/29912473/cross-cultural-validation-of-the-5-factor-structure-of-negative-symptoms-in-schizophrenia
#1
Anthony O Ahmed, Brian Kirkpatrick, Silvana Galderisi, Armida Mucci, Alessandro Rossi, Alessandro Bertolino, Paola Rocca, Mario Maj, Stefan Kaiser, Martin Bischof, Matthias N Hartmann-Riemer, Matthias Kirschner, Karoline Schneider, Maria Paz Garcia-Portilla, Anna Mane, Miguel Bernardo, Emilio Fernandez-Egea, Cui Jiefeng, Yao Jing, Tan Shuping, James M Gold, Daniel N Allen, Gregory P Strauss
Objective: Negative symptoms are currently viewed as having a 2-dimensional structure, with factors reflecting diminished expression (EXP) and motivation and pleasure (MAP). However, several factor-analytic studies suggest that the consensus around a 2-dimensional model is premature. The current study investigated and cross-culturally validated the factorial structure of BNSS-rated negative symptoms across a range of cultures and languages. Method: Participants included individuals diagnosed with a psychotic disorder who had been rated on the Brief Negative Symptom Scale (BNSS) from 5 cross-cultural samples, with a total N = 1691...
April 18, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29909766/-phenomenology-clinical-diagnostics-and-treatment-of-hallucinations
#2
Daniela Hubl
Phenomenology, clinical diagnostics and treatment of hallucinations Abstract. Hallucinations are perceptions without any stimulus. They occur typically in schizophrenia, but they can be found in other psychiatric or medical disorders as well. Recently, hallucinations have been increasingly reported to occur with a high prevalence in the general population and they are conceptualised as continuum from a physiological to pathological especially psychotic phenomenon. Schizophrenic hallucinations exhibit a special proximity to language and for this they can be considered as diagnostic...
June 2018: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/29898698/validity-and-reliability-of-the-kiddie-schedule-for-affective-disorders-and-schizophrenia-present-and-lifetime-version-dsm-5-k-sads-pl-5-spanish-version
#3
Francisco R de la Peña, Lino R Villavicencio, Juan D Palacio, Fernando J Félix, Marcela Larraguibel, Laura Viola, Silvia Ortiz, Marcos Rosetti, Andrea Abadi, Cecilia Montiel, Pablo A Mayer, Sofía Fernández, Aurora Jaimes, Miriam Feria, Liz Sosa, Andrés Rodríguez, Patricia Zavaleta, Daniela Uribe, Frinne Galicia, Diana Botero, Santiago Estrada, Arturo F Berber, Macarena Pi-Davanzo, Consuelo Aldunate, Gabriela Gómez, Ivannah Campodónico, Paula Tripicchio, Ignacio Gath, Manuel Hernández, Lino Palacios, Rosa E Ulloa
BACKGROUND: There are various language adaptations of the Schedule for Affective Disorders and Schizophrenia for School Age Children Present and Lifetime Version (K-SADS-PL). In order to comply with the changes in DSM classification, the Spanish edition of the interview was in need of update and evaluation. METHODS: K-SADS-PL was adapted to correspond to DSM-5 categories. All clinicians received training, and a 90% agreement was reached. Patients and their parents or guardians were interviewed and videotaped, and the videos were exchanged between raters...
June 14, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29896133/the-impact-of-aging-psychotic-symptoms-medication-and-brain-derived-neurotrophic-factor-on-cognitive-impairment-in-japanese-chronic-schizophrenia-patients
#4
Kiyokazu Atake, Tomoyuki Nakamura, Nobuhisa Ueda, Hikaru Hori, Asuka Katsuki, Reiji Yoshimura
Background: Cognitive impairment in schizophrenia can result in considerable difficulty in performing functions of daily life or social rehabilitation. Cognitive impairment in schizophrenia is related to various factors, such as the psychotic severity, aging, medication, and brain-derived neurotrophic factor (BDNF). To date, however, no studies investigating the impact of these factors on cognitive functioning in chronic schizophrenia patients have been performed. Objective: The aim of this study is to identify those factors that influence the cognitive functioning in patients with chronic schizophrenia...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29893410/fluphenazine-oral-versus-placebo-for-schizophrenia
#5
REVIEW
Hosam E Matar, Muhammad Qutayba Almerie, Stephanie J Sampson
BACKGROUND: Fluphenazine is one of the first drugs to be classed as an 'antipsychotic' and has been widely available for five decades. OBJECTIVES: To compare the effects of oral fluphenazine with placebo for the treatment of schizophrenia. To evaluate any available economic studies and value outcome data. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Trials Register (23 July 2013, 23 December 2014, 9 November 2016 and 28 December 2017 ) which is based on regular searches of CINAHL, BIOSIS, AMED, EMBASE, PubMed, MEDLINE, PsycINFO, and registries of clinical trials...
June 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29885556/higher-order-language-dysfunctions-as-a-possible-neurolinguistic-endophenotype-for-schizophrenia-evidence-from-patients-and-their-unaffected-first-degree-relatives
#6
Agnieszka Pawełczyk, Emila Łojek, Natalia Żurner, Marta Gawłowska-Sawosz, Tomasz Pawełczyk
The purpose of the study was to examine the presence of pragmatic dysfunctions in first episode (FE) subjects and their healthy first degree relatives as a potential endophenotype for schizophrenia. Thirty-four FE patients, 34 parents of the patients (REL) and 32 healthy controls (HC) took part in the study. Pragmatic language functions were evaluated with the Right Hemisphere Language Battery, attention and executive functions were controlled, as well as age and education level. The parents differed from HC but not from their FE offspring with regard to overall level of language and communication and the general knowledge component of language processing...
May 31, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29879600/a-systematic-review-of-a-functional-assessment-tool-ucsd-performance-based-skill-assessment-upsa
#7
REVIEW
Ana Claudia Becattini-Oliveira, Douglas de Farias Dutra, Bárbara Spenciere de Oliveira Campos, Verônica Carvalho de Araujo, Helenice Charchat-Fichman
Performance based assessment instruments have been employed in functional capacity measurement of mental disorders. The aim of this systematic review was to identify the psychometric properties of the UCSD Performance-based Skill Assessment (UPSA). A search was conducted using the PRISMA protocol and 'UPSA' as key word term on electronic databases, with a date range for articles published from 2001-2017. Published studies involving community-dwelling adults were included. Pharmacological and/or clinical interventions involving clinical outcomes and/or institutionalized samples were excluded...
May 18, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29876260/disrupted-modular-organization-of-primary-sensory-brain-areas-in-schizophrenia
#8
Cécile Bordier, Carlo Nicolini, Giulia Forcellini, Angelo Bifone
Abnormal brain resting-state functional connectivity has been consistently observed in patients affected by schizophrenia (SCZ) using functional MRI and other neuroimaging techniques. Graph theoretical methods provide a framework to investigate these defective functional interactions and their effects on the organization of brain connectivity networks. A few studies have shown altered distribution of connectivity within and between functional modules in SCZ patients, an indication of imbalanced functional segregation ad integration...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29867648/metaphor-comprehension-in-schizophrenic-patients
#9
REVIEW
Ileana Rossetti, Paolo Brambilla, Costanza Papagno
People with schizophrenia often exhibit difficulties to comprehend figurative expressions, such as irony, proverbs, metaphors and idioms, with a general proneness to neglect the figurative meaning and to accept the more literal one. This inability is usually referred to as concretism and it constitutes a clinical manifestation of the broader language dysfunction called Formal Thought Disorder. The current review focuses on the neuropsychological and neuroanatomical underpinnings of schizophrenics' misinterpretation of a subgroup of figurative expressions, i...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29865930/language-abnormality-in-deaf-people-with-schizophrenia-a-problem-with-classifiers
#10
G Chatzidamianos, R A McCarthy, M Du Feu, J Rosselló, P J McKenna
INTRODUCTION: Although there is evidence for language abnormality in schizophrenia, few studies have examined sign language in deaf patients with the disorder. This is of potential interest because a hallmark of sign languages is their use of classifiers (semantic or entity classifiers), a reference-tracking device with few if any parallels in spoken languages. This study aimed to examine classifier production and comprehension in deaf signing adults with schizophrenia. METHOD: Fourteen profoundly deaf signing adults with schizophrenia and 35 age- and IQ-matched deaf healthy controls completed a battery of tests assessing classifier and noun comprehension and production...
June 5, 2018: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/29861197/formal-thought-disorder-is-related-to-aberrations-in-language-related-white-matter-tracts-in-patients-with-schizophrenia
#11
Marialuisa Cavelti, Stephanie Winkelbeiner, Andrea Federspiel, Sebastian Walther, Katharina Stegmayer, Stéphanie Giezendanner, Karin Laimböck, Thomas Dierks, Werner Strik, Helge Horn, Philipp Homan
This study examined the hypothesis that a fronto-temporal disconnection in the language network underpins formal thought disorder (FTD) in schizophrenia. Forty-nine patients with a schizophrenia spectrum disorder (27 with mild FTD, 22 with severe FTD) and 26 healthy controls (HC) were included. Overall psychopathology and FTD were assessed by the Positive and Negative Syndrome Scale and the Thought, Language, and Communication scale, respectively. White matter (WM) microstructure was analysed using Tract-Based Spatial Statistics...
May 23, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29803018/a-narrative-meta-synthesis-of-how-people-with-schizophrenia-experience-facilitators-and-barriers-in-using-antipsychotic-medication-implications-for-healthcare-professionals
#12
REVIEW
Martin Salzmann-Erikson, Marie Sjödin
BACKGROUND: It is recognized that people who are diagnosed with schizophrenia often do not fully adhere with their antipsychotic prescription. The vast majority of previous research on the topic of medical adherence is limited to quantitative research methods, and in particular, to determining correlations. OBJECTIVES: The present review was designed to describe how people who are diagnosed with schizophrenia experience and narrate pharmacological treatment with antipsychotic medication...
May 23, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29800949/comparison-of-early-intervention-services-vs-treatment-as-usual-for-early-phase-psychosis-a-systematic-review-meta-analysis-and-meta-regression
#13
Christoph U Correll, Britta Galling, Aditya Pawar, Anastasia Krivko, Chiara Bonetto, Mirella Ruggeri, Thomas J Craig, Merete Nordentoft, Vinod H Srihari, Sinan Guloksuz, Christy L M Hui, Eric Y H Chen, Marcelo Valencia, Francisco Juarez, Delbert G Robinson, Nina R Schooler, Mary F Brunette, Kim T Mueser, Robert A Rosenheck, Patricia Marcy, Jean Addington, Sue E Estroff, James Robinson, David Penn, Joanne B Severe, John M Kane
Importance: The value of early intervention in psychosis and allocation of public resources has long been debated because outcomes in people with schizophrenia spectrum disorders have remained suboptimal. Objective: To compare early intervention services (EIS) with treatment as usual (TAU) for early-phase psychosis. Data Sources: Systematic literature search of PubMed, PsycINFO, EMBASE, and ClinicalTrials.gov without language restrictions through June 6, 2017...
May 2, 2018: JAMA Psychiatry
https://www.readbyqxmd.com/read/29778275/quantifying-the-effects-of-16p11-2-copy-number-variants-on-brain-structure-a-multisite-genetic-first-study
#14
Sandra Martin-Brevet, Borja Rodríguez-Herreros, Jared A Nielsen, Clara Moreau, Claudia Modenato, Anne M Maillard, Aurélie Pain, Sonia Richetin, Aia E Jønch, Abid Y Qureshi, Nicole R Zürcher, Philippe Conus, Wendy K Chung, Elliott H Sherr, John E Spiro, Ferath Kherif, Jacques S Beckmann, Nouchine Hadjikhani, Alexandre Reymond, Randy L Buckner, Bogdan Draganski, Sébastien Jacquemont
BACKGROUND: 16p11.2 breakpoint 4 to 5 copy number variants (CNVs) increase the risk for developing autism spectrum disorder, schizophrenia, and language and cognitive impairment. In this multisite study, we aimed to quantify the effect of 16p11.2 CNVs on brain structure. METHODS: Using voxel- and surface-based brain morphometric methods, we analyzed structural magnetic resonance imaging collected at seven sites from 78 individuals with a deletion, 71 individuals with a duplication, and 212 individuals without a CNV...
March 27, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29755393/language-lateralization-and-auditory-attention-impairment-in-young-adults-at-ultra-high-risk-for-psychosis-a-dichotic-listening-study
#15
Ingvild Aase, Kristiina Kompus, Jens Gisselgård, Inge Joa, Jan O Johannessen, Kolbjørn Brønnick
Objectives: Impaired attention and language functions are common in psychosis, but have been less explored in subjects with ultra-high risk for psychosis (UHR). The aim of the study was to investigate differences in language lateralization and auditory attention in UHR subjects compared to healthy controls with a dichotic listening paradigm. In addition, symptoms from The Structural Interview for Prodromal Syndromes (SIPS) were explored in relation to performance on dichotic listening. Methods: The UHR subjects ( n = 46, female = 28, mean age = 17...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29709491/resting-state-network-connectivity-and-metastability-predict-clinical-symptoms-in-schizophrenia
#16
Won Hee Lee, Gaelle E Doucet, Evan Leibu, Sophia Frangou
BACKGROUND: The functional architecture of resting-state networks (RSNs) is defined by their connectivity and metastability. Disrupted RSN connectivity has been amply demonstrated in schizophrenia while the role of metastability remains poorly defined. Here, we undertake a comprehensive characterisation of RSN organization in schizophrenia and test its contribution to the clinical profile of this disorder. METHODS: We extracted RSNs representing the default mode (DMN), central executive (CEN), salience (SAL), language (LAN), sensorimotor (SMN), auditory (AN) and visual (VN) networks from resting-state functional magnetic resonance imaging data obtained from patients with schizophrenia (n = 85) and healthy individuals (n = 48)...
April 27, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29692287/measuring-disorganized-speech-in-schizophrenia-automated-analysis-explains-variance-in-cognitive-deficits-beyond-clinician-rated-scales
#17
K S Minor, J A Willits, M P Marggraf, M N Jones, P H Lysaker
BACKGROUND: Conveying information cohesively is an essential element of communication that is disrupted in schizophrenia. These disruptions are typically expressed through disorganized symptoms, which have been linked to neurocognitive, social cognitive, and metacognitive deficits. Automated analysis can objectively assess disorganization within sentences, between sentences, and across paragraphs by comparing explicit communication to a large text corpus. METHOD: Little work in schizophrenia has tested: (1) links between disorganized symptoms measured via automated analysis and neurocognition, social cognition, or metacognition; and (2) if automated analysis explains incremental variance in cognitive processes beyond clinician-rated scales...
April 25, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29680909/employment-support-needs-of-people-with-schizophrenia-a-scoping-study
#18
REVIEW
Viviana R Carmona, Juana Gómez-Benito, J Emilio Rojo-Rodes
Purpose People with schizophrenia continue to encounter barriers to employment acquisition. The aim of this scoping study was to identify and synthesize existent evidence about the employment support needs of people diagnosed with schizophrenia. Methods Five relevant databases were used: CINAHL, Medline, PsycINFO, SCOPUS, and Web of Science. Additional material of potential interest was identified through the references of the retrieved articles. A manual search for publications from the 3 months immediately prior to the electronic search was carried out in specialized journals...
April 21, 2018: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/29670547/medications-used-for-cognitive-enhancement-in-patients-with-schizophrenia-bipolar-disorder-alzheimer-s-disease-and-parkinson-s-disease
#19
REVIEW
Wen-Yu Hsu, Hsien-Yuan Lane, Chieh-Hsin Lin
Background/aims: Cognitive impairment, which frequently occurs in patients with schizophrenia, bipolar disorder, Alzheimer's disease, and Parkinson's disease, has a significant impact on the daily lives of both patients and their family. Furthermore, since the medications used for cognitive enhancement have limited efficacy, the issue of cognitive enhancement still remains a clinically unsolved challenge. Sampling and methods: We reviewed the clinical studies (published between 2007 and 2017) that focused on the efficacy of medications used for enhancing cognition in patients with schizophrenia, bipolar disorder, Alzheimer's disease, and Parkinson's disease...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29660081/data-driven-analysis-of-functional-connectivity-reveals-a-potential-auditory-verbal-hallucination-network
#20
Dustin Scheinost, Fuyuze Tokoglu, Michelle Hampson, Ralph Hoffman, R Todd Constable
Schizophrenia is a severe global health problem, with over half of such patients experiencing auditory verbal hallucinations (AVHs). A better understanding of the neural correlates differentiating patients experiencing AVHs from patients not experiencing AVHs and healthy controls may identify targets that lead to better treatment strategies for AVHs. Employing 2 data-driven, voxel-based measure of functional connectivity, we studied 46 patients with schizophrenia or schizoaffective disorder (28 experiencing AVHs and 18 not experiencing AVHs)...
April 5, 2018: Schizophrenia Bulletin
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