Miriam Capri, Maria Conte, Erika Ciurca, Chiara Pirazzini, Paolo Garagnani, Aurelia Santoro, Federica Longo, Stefano Salvioli, Patrick Lau, Ralf Moeller, Jens Jordan, Thomas Illig, Maria-Moreno Villanueva, Markus Gruber, Alexander Bürkle, Claudio Franceschi, Jörn Rittweger
Spaceflight and its associated stressors, such as microgravity, radiation exposure, confinement, circadian derailment and disruptive workloads represent an unprecedented type of exposome that is entirely novel from an evolutionary stand point. Within this perspective, we aimed to review the effects of prolonged spaceflight on immune-neuroendocrine systems, brain and brain-gut axis, cardiovascular system and musculoskeletal apparatus, highlighting in particular the similarities with an accelerated aging process...
June 2023: Ageing Research Reviews