keyword
https://read.qxmd.com/read/33531050/prevalence-of-rhesus-d-negative-blood-type-and-the-challenges-of-rhesus-d-immunoprophylaxis-among-obstetric-population-in-ethiopia-a-systematic-review-and-meta-analysis
#21
REVIEW
Asteray Assmie Ayenew
BACKGROUND: Transplacental or fetomaternal hemorrhage (FMH) may occur during pregnancy or at delivery and lead to immunization to the D antigen if the mother is Rh-negative and the baby is Rh-positive. This can result in hemolytic disease of the fetus and newborn (HDFN) in subsequent D-positive pregnancies. Therefore, the aim of this systematic review and meta-analysis was to estimate distribution of ABO and Rh (D) blood groups among pregnant women in Ethiopia. METHOD: We searched PubMed, Google Scholar, EMBASE, Cochrane Library, HINARI, AFRO Library Databases, and African Online Journal databases for all available studies using the following keywords: "High rhesus (Rh(D)) negative frequency", "ABO blood group distribution", "haemolytic disease of the newborn (HDN)", "rh isoimmunization", "anti-RhD immunoglobulin", "D-negative pregnancies", "Frequency", "ABO and Rh blood group distribution", "feto-maternal hemorrhage", "rhesus D negative pregnant mothers", "kleihauer-betke test (KBT)", "Neonatal Hyperbilirubinemia", "non-sensitized RhD-negative pregnant women", "antenatal anti-D immunoglobulin prophylaxis", "Hemolytic disease of the newborn (alloimmunization), Ethiopia...
February 2, 2021: Maternal Health, Neonatology and Perinatology
https://read.qxmd.com/read/32867556/prolonged-thrombocytopenia-in-a-neonate-with-noonan-syndrome-a-case-report
#22
JOURNAL ARTICLE
Meng Li, Jinghui Zhang, Nianzheng Sun
We report a case of a Chinese neonate who was diagnosed with Noonan syndrome and had persistent, self-limited thrombocytopenia. The neonate was admitted to the Neonatology Department 20 minutes after birth because of respiratory distress. From birth until 2 months of age, platelet values fluctuated between approximately 6 and 30 × 109 /L. There was no intracranial hemorrhage. However, the child had a transient hypocalcemic seizure and fever. We excluded thrombocytopenia caused by perinatal asphyxia, immune thrombocytopenia, fetomaternal alloimmune thrombocytopenia, juvenile myelomonocytic leukemia, and chromosome 13, 18, and 21 trisomy syndromes...
August 2020: Journal of International Medical Research
https://read.qxmd.com/read/32458481/prevalence-of-red-blood-cell-and-non-red-blood-cell-targeted-autoantibodies-in-alloimmunized-postpartum-women
#23
JOURNAL ARTICLE
Henk Schonewille, Leo M G van de Watering, Dick Oepkes, Enrico Lopriore, Christa M Cobbaert, Anneke Brand
BACKGROUND AND OBJECTIVES: Alloantibodies against red-blood-cell (RBC) antigens often coincide with alloantibodies against leucocytes and platelets and sometimes with autoantibodies towards various antigens. Chimerism may be one of the factors responsible for the combination of allo- and autoantibodies. Women with alloantibodies against RBC antigens causing haemolytic disease of the fetus and neonate may need to receive intrauterine transfusions. These transfusions increase not only maternal antibody formation but also fetomaternal bleeding and may enhance fetal chimerism...
November 2020: Vox Sanguinis
https://read.qxmd.com/read/32266719/a-new-efficient-tool-for-non-invasive-diagnosis-of-fetomaternal-platelet-antigen-incompatibility
#24
JOURNAL ARTICLE
Yasmine Ouzegdouh Mammasse, Christophe Chenet, Damien Drubay, Corinne Martageix, Jean-Pierre Cartron, William Vainchenker, Rachel Petermann
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is the consequence of platelet destruction by maternal alloantibodies against fetal human platelet antigens (HPA). This may result in intracranial haemorrhages (ICH) or even fetal death. Currently, fetal HPA genotyping is performed using invasive procedures. Here, we carried out a proof-of-concept study for non-invasive prenatal diagnosis of fetal platelet genotyping in four HPA systems (HPA-1, -3, -5 and-15) by droplet digital polymerase chain reaction (ddPCR) using cell-free DNA extracts from the plasma of 47 pregnant women with suspected, or history of, FNAIT...
September 2020: British Journal of Haematology
https://read.qxmd.com/read/31974930/hereditary-axonal-neuropathy-related-to-mme-gene-mutation-in-a-family-with-fetomaternal-alloimmune-glomerulonephritis
#25
JOURNAL ARTICLE
M Dupuis, J M Raymackers, N Ackermans, S Boulanger, C Verellen-Dumoulin
We report a consanguineous family with a homozygous and heterozygous membrane metallo-endopeptidase (MME) mutation (c.467delC) and two clinical conditions: fetomaternal alloimmune membranous glomerulopathy (FMG) and hereditary motor and sensory axonal neuropathy. The penetrance of both phenotypes was variable. Some individuals experienced unusually fast neurological degradation. Pain and vasomotor signs were frequent complaints, possibly due to a loss of the neutral endopeptidase (NEP, the MME gene product) function and its subsequent inability to degrade substance P and vasomotor peptides...
February 2020: Acta Neurologica Belgica
https://read.qxmd.com/read/31530475/maternal-alloimmune-igg-causes-anti-glomerular-basement-membrane-disease-in-perinatal-transgenic-mice-that-express-human-laminin-%C3%AE-5
#26
JOURNAL ARTICLE
Dale R Abrahamson, Brooke M Steenhard, Larysa Stroganova, Adrian Zelenchuk, Patricia L St John, Margaret G Petroff, Manuel Patarroyo, Dorin Bogdan Borza
Mammalian immune systems are not mature until well after birth. However, transfer of maternal IgG to the fetus and newborn usually provides immunoprotection from infectious diseases. IgG transfer occurs before birth in humans across the placenta and continues after birth across the intestine in many mammalian species, including rodents. Transfer, which is mediated by the neonatal IgG Fc receptor, occurs by transcytosis across placental syncytiotrophoblasts and intestinal epithelium. Although maternal IgG is generally beneficial, harmful maternal allo- and autoantibodies can also be transferred to the fetus/infant, resulting in serious disease...
December 2019: Kidney International
https://read.qxmd.com/read/30968555/prenatal-management-of-pregnancies-at-risk-of-fetal-neonatal-alloimmune-thrombocytopenia-fnait-scientific-impact-paper-no-61
#27
JOURNAL ARTICLE
F Regan, C C Lees, B Jones, K H Nicolaides, R C Wimalasundera, A Mijovic
WHAT IS IT?: Fetal neonatal alloimmune thrombocytopenia (FNAIT), also known as neonatal alloimmune thrombocytopenia (NAIT) or fetomaternal alloimmune thrombocytopenia (FMAIT), is a rare condition which affects a baby's platelets. This can put them at risk of problems with bleeding, particularly into the brain. One baby per week in the UK may be seriously affected and milder forms can affect one in every 1000 births. HOW IS IT CAUSED?: Platelets are blood cells that are very important in helping blood to clot...
September 2019: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/30620409/prediction-of-fetal-blood-group-and-platelet-antigens-from-maternal-plasma-using-next-generation-sequencing
#28
JOURNAL ARTICLE
Agnieszka Orzińska, Katarzyna Guz, Michal Mikula, Anna Kluska, Aneta Balabas, Jerzy Ostrowski, Małgorzata Uhrynowska, Izabella Kopeć, Marzena Dębska, Katarzyna Luterek, Ewa Brojer
BACKGROUND: Fetuses whose mothers have produced antibodies to red blood cell (RBC) or platelet antigens are at risk of being affected by hemolytic disease or alloimmune thrombocytopenia, respectively, only if they inherit the incompatible antigen. Noninvasive diagnosis of the fetal antigen is employed for management of immunized pregnancies, but the specific detection of SNPs, encoding the majority of antigens, in maternal plasma is still a challenge. We applied targeted next-generation sequencing (NGS) to predict the fetal antigen based on the detection of fetomaternal chimerism...
March 2019: Transfusion
https://read.qxmd.com/read/30222855/noninvasive-prenatal-diagnosis-by-cell-free-dna-screening-for-fetomaternal-hpa-1a-platelet-incompatibility
#29
JOURNAL ARTICLE
Marta Ferro, Hada C Macher, Gema Fornés, Jesús Martín-Sánchez, Pilar Jimenez-Arriscado, Patrocinio Molinero, José A Pérez-Simón, Juan M Guerrero, Amalia Rubio
BACKGROUND: The development of new noninvasive approaches for the diagnosis of human platelet antigen (HPA)-1 fetomaternal incompatibility has become of great interest. These approaches allow determination of whether the fetus is incompatible or not with the mother and a decision on antenatal therapy to avoid fetal or neonatal alloimmune thrombocytopenia (FNAIT). The objective of this work was to perform rapid, noninvasive prenatal test for HPA-1ab fetal antigen detection after the detection of an HPA-1-homozygous mother by using plasma cell-free DNA (cfDNA)...
October 2018: Transfusion
https://read.qxmd.com/read/29886774/labor-induction-in-indicated-moderate-to-late-preterm-birth
#30
JOURNAL ARTICLE
Charline Bertholdt, Olivier Morel, Matthieu Dap, Marion Choserot, Hélène Minebois
Introduction: The primary objective of this study was to evaluate the success of labor induction for indicated moderate and late preterm birth. As secondary objectives, the mode of delivery was assessed. Material and methods: This is an observational study conducted in a tertiary care unit between 2013 and 2015. All patients who underwent labor induction for indicated preterm birth between 32+0 and 36+6 weeks of gestation (as premature rupture of membranes, preeclampsia, intrauterine growth restriction, fetomaternal alloimmunization, or intrahepatic cholestasis) were included...
January 2020: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/29191743/severe-neonatal-thrombocytopenia-due-to-fetomaternal-anti-a-alloimmunization-a-case-report
#31
JOURNAL ARTICLE
Gerald Bertrand, Anne Leguen, Laurence Delugin, Virginie Renac
No abstract text is available yet for this article.
August 2018: Pediatrics and Neonatology
https://read.qxmd.com/read/28837581/fetal-exposure-to-maternal-human-platelet-antigen-1a-does-not-induce-tolerance-an-analytical-observational-study
#32
JOURNAL ARTICLE
Mette Kjær, Heidi Tiller, Gøril Heide, Jens Kjeldsen-Kragh, Bjørn Skogen, Anne Husebekk
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a disease that may cause severe bleeding complications with risk of perinatal death or lifelong disability. The main cause of FNAIT is maternal antibodies against human platelet antigen (HPA)-1a. Both fetomaternal bleeding and transplacental trafficking of fetal cells during pregnancy could be the cause of alloimmunization. Persistence of fetal cells in the mother (fetal microchimerism) and maternal cells in the child (maternal microchimerism) are well-recognized phenomena...
2017: PloS One
https://read.qxmd.com/read/28419453/obstetrics-and-gynecology-physician-knowledge-of-rh-immune-globulin-prophylaxis
#33
JOURNAL ARTICLE
Amy Yu, Erin Morris, Richard Adams, Mark K Fung
BACKGROUND: Previous studies have shown that more than 20% of laboratories would have recommended inaccurate doses of Rh immune globulin (RhIG) in hypothetical cases. Efforts have been made in educating laboratories in correct dosing calculations; however, obstetricians are most often responsible for ordering RhIG. The objective of this study was to assess knowledge of RhIG indications and dosing among obstetrics and gynecology (OB/GYN) physicians in the United States. STUDY DESIGN AND METHODS: An anonymous 17- question online survey was distributed to all OB/GYN resident and attending physicians affiliated with US residency training programs...
June 2017: Transfusion
https://read.qxmd.com/read/27806668/contemporary-management-of-neonatal-alloimmune-thrombocytopenia-good-outcomes-in-the-intravenous-immunoglobulin-era-results-from-the-australian-neonatal-alloimmune-thrombocytopenia-registry
#34
JOURNAL ARTICLE
Gemma L Crighton, Ri Scarborough, Zoe K McQuilten, Louise E Phillips, Helen F Savoia, Bronwyn Williams, Rhonda Holdsworth, Amanda Henry, Erica M Wood, Stephen A Cole
OBJECTIVE: To describe the natural history, antenatal and postnatal therapy, and clinical outcomes of Australian patients with fetomaternal/neonatal alloimmune thrombocytopenia (NAIT) recorded in the Australian NAIT registry. METHODS: Analysis of registry data of Australian mothers treated antenatally for NAIT and any fetus/newborn with thrombocytopenia (TCP) and maternal human platelet antigen (HPA) antibodies. RESULTS: Ninety four potential cases (91 pregnancies; three twin pregnancies) were registered between December 2004 and September 2015 with 76 confirmed or treated as NAIT...
October 2017: Journal of Maternal-fetal & Neonatal Medicine
https://read.qxmd.com/read/27494244/flow-cytometry-in-detection-of-fetal-red-blood-cells-and-maternal-f-cells-to-identify-fetomaternal-hemorrhage
#35
JOURNAL ARTICLE
Mariela Granero Farias, Suzane Dal Bó, Simone Martins de Castro, Aline Reis da Silva, Joyce Bonazzoni, Luciana Scotti, Sergio H Almeida Martins Costa
Accurate detection and quantitation of fetomaternal hemorrhage (FMH) is critical to the obstetric management of rhesus D alloimmunization in Rh-negative pregnant women. The flow cytometry is based on the detection of fetal red blood cells using a monoclonal anti-HbF antibody, and is the method most indicated for this estimation. The objective of this study was to quantify fetal red blood cell levels of pregnant women using flow cytometry. We analyzed 101 peripheral blood samples from Rh-negative and Rh-positive women, whose mean age was 24 years (20-32 years), after vaginal delivery or cesarean section...
2016: Fetal and Pediatric Pathology
https://read.qxmd.com/read/26645993/further-observations-on-the-clinical-significance-and-inheritance-of-the-low-frequency-platelet-antigen-hpa-28bw
#36
JOURNAL ARTICLE
Geoffrey Lucas, Anthony Poles, Marcin J Woźniak, Ruth Gilmore
BACKGROUND: Most recently described human platelet antigens (HPAs) have been low-frequency polymorphisms identified in cases of fetomaternal alloimmune thrombocytopenia (FMAIT). There is limited opportunity to study the clinical significance or different antenatal management strategies in cases involving low-frequency HPA antibodies because many are single pregnancies. We have previously described a low-frequency platelet (PLT) antigen, HPA-28bw, implicated in FMAIT in two of the three infants in the same family...
April 2016: Transfusion
https://read.qxmd.com/read/26599469/prolonged-thrombocytopenia-in-a-child-with-severe-neonatal-alloimmune-reaction-and-noonan-syndrome
#37
JOURNAL ARTICLE
Inês Salva, Sara Batalha, Raquel Maia, Paula Kjollerstrom
Fetomaternal alloimmune thrombocytopenia (FMAIT) caused by maternal antibodies is the leading cause of severe neonatal thrombocytopenia. A 1-month-old Caucasian girl was referred to our Hematology Clinic for persistent thrombocytopenia diagnosed after a bleeding episode. Diagnostic tests suggested FMAIT. Mild thrombocytopenia persisted for 18 months, and subsequent findings of dysmorphic facies, short stature and mild pulmonary stenosis led to the hypothesis of Noonan syndrome (NS), which was confirmed by genetic test...
June 2016: Platelets
https://read.qxmd.com/read/26173471/a-multicenter-validation-of-recombinant-%C3%AE-3-integrin-coupled-beads-to-detect-human-platelet-antigen-1-alloantibodies-in-498-cases-of-fetomaternal-alloimmune-thrombocytopenia
#38
JOURNAL ARTICLE
Winnie Chong, Ernest Turro, Paul Metcalfe, Rizwan Yusuf, Yves Mérieux, Dominique Rigal, Leendert Porcelijn, Elly Huiskes, Geoff Lucas, Nina Bendukidze, Ann Green, Rita Fontão-Wendel, Anne Husebekk, Jonathan Dixey, Alan Guest, Rosey Mushens, Willem H Ouwehand, Cristina V Navarrete
BACKGROUND: Fetomaternal alloimmune thrombocytopenia (FMAIT) is caused by human platelet (PLT) antigen (HPA) incompatibility. Beads coupled with recombinant β3 integrins, displaying the biallelic HPA-1 epitopes (rHPA-1), have been shown to detect HPA-1a alloantibodies implicated in FMAIT. This report describes a multicenter validation of the beads using the results of well-characterized samples to define the optimum parameters for analysis of a large cohort of 498 clinical samples. STUDY DESIGN AND METHODS: Fifty-one blinded quality assurance (QA) samples were tested by six laboratories to standardize the rHPA-1 bead assay and to develop an algorithm for sample classification...
November 2015: Transfusion
https://read.qxmd.com/read/25736586/two-cases-of-asymptomatic-massive-fetomaternal-hemorrhage
#39
JOURNAL ARTICLE
Alexis R Peedin, Marshall A Mazepa, Yara A Park, Eric T Weimer, John L Schmitz, Jay S Raval
Evaluation of fetomaternal hemorrhage (FMH) in the immediate postpartum period is critical for the timely administration of Rh immunoglobulin (RhIG) prophylaxis to minimize the risk of alloimmunization in D-negative mothers of D-positive newborns. We report a series of two clinically-unsuspected cases of massive FMHs identified at our university medical center. Retrospective records of two cases of massive FMH were investigated using the electronic medical record. After positive fetal bleed screens, flow cytometric analysis for hemoglobin F was performed to quantify the volume of the hemorrhages in both cases...
April 2015: Transfusion and Apheresis Science
https://read.qxmd.com/read/25723631/lessons-from-a-rare-disease-igg-subclass-and-disease-severity-in-alloimmune-antenatal-membranous-nephropathy
#40
COMMENT
Laurence H Beck
Fetomaternal alloimmunization against neutral endopeptidase (NEP) is a rare cause of antenatal membranous nephropathy, yet lessons from such cases continue to elucidate important pathophysiologic points. Vivarelli and colleagues describe two recent cases of this disease and demonstrate that despite a common genetic cause, differences in maternal anti-NEP IgG subclass modulate disease severity through such mechanisms as complement activation and enzyme inhibition.
March 2015: Kidney International
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