Xingli Liu, Cunwen Ma, Shiping Wang, Zhengrong Liang, Juntao Yang, Jun Zhou, Yi Shu, Zhengying He, Jilong Zong, Lizhi Wu, Peiqian Peng, Yi Su, Meng Gao, Kaiming Shen, Hong Zhao, Jilu Ruan, Shaoxuan Ji, Yunhui Yang, Taisong Tang, Zongfa Yang, Guangyin Luo, Meng Zeng, Weiwan Zhang, Bo He, Xiaoguang Cheng, Gang Wang, Ling Wang, Liang Lyu
INTRODUCTION: Musculoskeletal system gradually degenerates with aging, and a hypoxia environment at a high altitude may accelerate this process. However, the comprehensive effects of high-altitude environments on bones and muscles remain unclear. This study aims to compare the differences in bones and muscles at different altitudes, and to explore the mechanism and influencing factors of the high-altitude environment on the skeletal muscle system. METHODS: This is a prospective, multicenter, cohort study, which will recruit a total of 4000 participants over 50 years from 12 research centers with different altitudes (50m~3500m)...
2022: Frontiers in Endocrinology