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Influenza and pregnancy

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https://www.readbyqxmd.com/read/28726613/human-metapneumovirus-and-other-respiratory-viral-infections-during-pregnancy-and-birth-nepal
#1
Jennifer L Lenahan, Janet A Englund, Joanne Katz, Jane Kuypers, Anna Wald, Amalia Magaret, James M Tielsch, Subarna K Khatry, Stephen C LeClerq, Laxman Shrestha, Mark C Steinhoff, Helen Y Chu
Human metapneumovirus (HMPV) is a respiratory virus that can cause severe lower respiratory tract disease and even death, primarily in young children. The incidence and characteristics of HMPV have not been well described in pregnant women. As part of a trial of maternal influenza immunization in rural southern Nepal, we conducted prospective, longitudinal, home-based active surveillance for febrile respiratory illness during pregnancy through 6 months postpartum. During 2011-2014, HMPV was detected in 55 of 3,693 women (16...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28723925/immunologic-response-to-vaccine-challenge-in-pregnant-ptpn22-r620w-carriers-and-non-carriers
#2
Shelly H Tien, Juliet N Crabtree, Heather L Gray, Erik J Peterson
OBJECTIVES: Influenza infection is a significant cause of respiratory morbidity among pregnant women. Seasonal influenza vaccination engages innate immune receptors to promote protective immunity. A coding polymorphism (R620W) in PTPN22 imparts elevated risk for human infection and autoimmune disease, predisposes to diminished innate immune responses, and associates with reduced immunization responses. We sought to quantify the effects of PTPN22-R620W on humoral and cell-mediated immune responses to the inactivated influenza vaccine among healthy pregnant women...
2017: PloS One
https://www.readbyqxmd.com/read/28720851/microneedle-patch-delivery-of-influenza-vaccine-during-pregnancy-enhances-maternal-immune-responses-promoting-survival-and-long-lasting-passive-immunity-to-offspring
#3
E Stein Esser, Joanna A Pulit-Penaloza, Haripriya Kalluri, Devin McAllister, Elena V Vassilieva, Elizabeth Q Littauer, Nadia Lelutiu, Mark R Prausnitz, Richard W Compans, Ioanna Skountzou
Influenza virus causes life-threatening infections in pregnant women and their newborns. Immunization during pregnancy is the most effective means of preventing maternal and infant mortality/morbidity; however, influenza vaccination rates of pregnant women remain under 50%. Furthermore, the availability of vaccines in low-resource populations is limited. Skin immunization with microneedle patches (MN) is a novel and safe vaccination platform featuring thermostable vaccine formulations. Cold-chain independence and the potential for self-administration can expand influenza vaccination coverage in developing countries...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708952/influenza-vaccination-during-pregnancy-for-prevention-of-influenza-confirmed-illness-in-the-infants-a-systematic-review-and-meta-analysis
#4
Marta C Nunes, Shabir A Madhi
Infants younger than 6 months of age are at particular risk for serious illness from influenza infection. Currently available influenza vaccines are, however, not licensed for use in infants <6 months old. Influenza vaccination during pregnancy elicits robust antibody responses in the women that will protect the infants against influenza infection during the first few months of life. We aimed to determine the impact of influenza vaccination during pregnancy to prevent laboratory-confirmed influenza infection and influenza-associated hospitalisations in infants <6 months old...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28686396/-recommendations-for-the-vaccination-of-pregnant-women-a-booster-injection
#5
Yolanda Mueller, Christiane Sigrid Eberhardt, Alessandro Diana, Begoña Martinez De Tejada
For several decades we have avoided the immunisation of pregnant women, with the only exception being that of the tetanus vaccination in the absence of a previous basic immunisation. Nowadays, it is strongly advised to give several vaccines specifically during pregnancy : maternal immunisations against pertussis and influenza have been shown to prevent complications in both the foetus and the newborn as well as the woman during pregnancy and after delivery. This article aims to review these recommendations, their rationale and to address potential concerns that are often raised by physicians and patients...
October 12, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28654900/specific-microrna-library-of-ifn-%C3%AF-on-bovine-endometrial-epithelial-cells
#6
Haichong Wu, Tao Zhang, Xiaofei Ma, Kangfeng Jiang, Gan Zhao, Changwei Qiu, Ganzhen Deng
IFN-τ is specifically secreted by the conceptus in ruminants during early pregnancy, and it plays a vital role in the immunological function of pregnancy. However, its mechanism involving microRNA (miRNA) is still not well understood. Deep sequencing was used to explore the specific miRNA library of IFN-τ on bovine endometrial epithelial cells (bEECs). The results showed that 574 known bovine miRNAs and 109 novel miRNAs were identified. We found 74 differentially expressed miRNAs, including 30 commonly expressed miRNAs in the experiment...
June 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654742/the-safety-and-effectiveness-of-vaccination-against-influenza-and-pertussis-in-pregnant-women
#7
Ewa Augustynowicz, Anna Lutyńska, Anna Piotrowska, Iwona Paradowska- Stankiewicz
In recent years a large amount of data has become available with regard to vaccinating women during pregnancy against influenza and against pertussis. The data comes from observational studies conducted when vaccine was administered as a part of a vaccination campaign, retrospective evaluations of databases and surveillance of the adverse post-vaccination events. Popularization of knowledge about the importance of immunization in this group and educating pregnant women about vaccination should be an essential element of health promotion and prevention programs...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28621647/timeliness-and-completeness-of-routine-childhood-vaccinations-in-children-by-two-years-of-age-in-alberta-canada
#8
Vineet Saini, Shannon E MacDonald, Deborah A McNeil, Sheila W McDonald, James D Kellner, Sarah A Edwards, Victoria Stagg, Suzanne Tough
OBJECTIVES: Assessing timeliness and completeness of vaccine administration is important for evaluating the effectiveness of immunization programs. Few studies have reported timeliness, particularly in Canada. The objective of this study was to examine timeliness of the receipt of vaccination for each routine childhood recommended vaccine by 24 months of age among children in a community-based pregnancy cohort in Calgary, Alberta. METHODS: Survey data from a community-based pregnancy cohort in Alberta were linked to Public Health vaccination records of children (n = 2763)...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28584855/febrile-rhinovirus-illness-during-pregnancy-is-associated-with-low-birth-weight-in-nepal
#9
Erin K Philpott, Janet A Englund, Joanne Katz, James Tielsch, Subarna Khatry, Stephen C LeClerq, Laxman Shrestha, Jane Kuypers, Amalia S Magaret, Mark C Steinhoff, Helen Y Chu
BACKGROUND: Adverse birth outcomes, including low birth weight (LBW), defined as <2500 grams, small-for-gestational-age (SGA), and prematurity, contribute to 60%-80% of infant mortality worldwide and may be related to infections during pregnancy. The aim of this study was to assess whether febrile human rhinovirus (HRV) illness is associated with adverse birth outcomes. METHODS: Active household-based weekly surveillance was performed for respiratory illness episodes in pregnant women as part of a community-based, prospective, randomized trial of maternal influenza immunization in rural Nepal...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28575286/efficacy-of-maternal-influenza-vaccination-against-all-cause-lower-respiratory-tract-infection-hospitalizations-in-young-infants-results-from-a-randomized-controlled-trial
#10
Marta C Nunes, Clare L Cutland, Stephanie Jones, Sarah Downs, Adriana Weinberg, Justin R Ortiz, Kathleen M Neuzil, Eric A F Simões, Keith P Klugman, Shabir A Madhi
Background: Influenza immunization of pregnant women protects their young infants against laboratory-confirmed influenza infection. Influenza infection might predispose to subsequent bacterial infections that cause severe pneumonia. In a secondary analysis of a randomized clinical trial (RCT), we evaluated the effect of maternal vaccination on infant hospitalizations for all-cause acute lower respiratory tract infection (ALRI). Methods: Infants born to women who participated in a double-blind placebo-controlled RCT in 2011 and 2012 on the efficacy of trivalent inactivated influenza vaccine (IIV) during pregnancy were followed during the first 6 months of life...
May 29, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28557314/estradiol-and-progesterone-influence-on-influenza-infection-and-immune-response-in-a-mouse-model
#11
Sarah M Davis, Leigh M Sweet, Karen H Oppenheimer, Benjamin T Suratt, Mark Phillippe
PROBLEM: Influenza infection severity may be mediated by estradiol and/or progesterone. METHOD OF STUDY: An exploratory study was designed to evaluate 17-β-estradiol and progesterone on influenza infection and examine immune-mediated response in a mouse model. Inoculation with placebo or mouse-adapted H1N1 influenza virus occurred. Treatment groups included 17-β-estradiol, progesterone, ovariectomy, and pregnancy. Mice were assessed for morbidity and mortality...
May 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28552997/implementation-of-the-recommendation-to-vaccinate-pregnant-women-against-seasonal-influenza-vaccination-rates-and-acceptance
#12
Sascha Baum, Thomas Hitschold, Anouck Becker, Sigrun Smola, Erich Solomayer, Achim Rody, Jürgen Rissland
Introduction In Germany vaccination recommendations are revised annually and published by the Standing Committee on Vaccination at the Robert Koch Institute (STIKO). In 2010 the vaccination recommendations were amended to include the proposal that pregnant women in the 2nd trimester of pregnancy and pregnant women with additional underlying disease in the 1st trimester of pregnancy should be vaccinated against seasonal influenza. This paper reports on vaccination rates and the factors influencing them. Method A cross-sectional study was carried out in two level 1 perinatal centers in two different German federal states (Saarland and Rhineland-Palatinate) during the influenza seasons of 2012/2013 and 2013/2014...
April 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28550954/first-trimester-influenza-vaccination-and-risks-for-major-structural-birth-defects-in-offspring
#13
Elyse Olshen Kharbanda, Gabriela Vazquez-Benitez, Paul A Romitti, Allison L Naleway, T Craig Cheetham, Heather S Lipkind, Nicola P Klein, Grace Lee, Michael L Jackson, Simon J Hambidge, Natalie McCarthy, Frank DeStefano, James D Nordin
OBJECTIVE: To examine risks for major structural birth defects in infants after first trimester inactivated influenza vaccine (IIV) exposures. STUDY DESIGN: In this observational study, we used electronic health data from 7 Vaccine Safety Datalink sites to examine risks for selected major structural defects in infants after maternal IIV exposure. Vaccine exposures for women with continuous insurance enrollment through pregnancy who delivered singleton live births between 2004 and 2013 were identified from standardized files...
May 24, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28522338/year-round-influenza-immunisation-during-pregnancy-in-nepal-a-phase-4-randomised-placebo-controlled-trial
#14
Mark C Steinhoff, Joanne Katz, Janet A Englund, Subarna K Khatry, Laxman Shrestha, Jane Kuypers, Laveta Stewart, Luke C Mullany, Helen Y Chu, Steven C LeClerq, Naoko Kozuki, Monica McNeal, Adriana M Reedy, James M Tielsch
BACKGROUND: Influenza immunisation during pregnancy is recommended but not widely implemented in some low-income regions. We assessed the safety and efficacy in mothers and infants of year-round maternal influenza immunisation in Nepal, where influenza viruses circulate throughout the year. METHODS: In this phase 4, randomised, placebo-controlled trial, we enrolled two consecutive sequential annual cohorts of pregnant women from the Sarlahi district in southern Nepal...
May 15, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28514782/a-systematic-review-and-meta-analysis-of-influenza-a-virus-infection-during-pregnancy-associated-with-an-increased-risk-for-stillbirth-and-low-birth-weight
#15
Jing He, Zhi-Wei Liu, Yong-Ping Lu, Tao-Yuan Li, Xu-Jing Liang, Petra C Arck, Si-Min Huang, Berthold Hocher, You-Peng Chen
BACKGROUND/AIMS: Impaired pregnancy outcomes, such as low birth weight are associated with increased disease risk in later life, however little is known about the impact of common infectious diseases during pregnancy on birth weight. The study had two aims: a) to investigate risk factors of influenza virus infection during pregnancy, and b) to analyze the impact of influenza virus infection on pregnancy outcome, especially birth weight. METHODS: Prospective and retrospective observational studies found in PubMed, MEDLINE, Embase, Google Scholar, and WangFang database were included in this meta analysis...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28510067/immunization-during-pregnancy-impact-on-the-infant
#16
REVIEW
Kirsten P Perrett, Terry M Nolan
Maternal immunization has undergone a paradigm shift in recent years, as women and healthcare providers accept and recognize the benefits of this strategy not only for the pregnant woman but also for the developing fetus and young infant. This article reviews the evidence for active immunization during pregnancy, with an emphasis on perinatal and infant outcomes. Current recommendations for immunization during pregnancy are presented, with particular focus on the routinely recommended vaccines during pregnancy: influenza and Tdap (tetanus, diphtheria, and pertussis)...
August 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28495223/feasibility-of-text-message-influenza-vaccine-safety-monitoring-during-pregnancy
#17
Melissa S Stockwell, Maria Cano, Kathleen Jakob, Karen R Broder, Cynthia Gyamfi-Bannerman, Paula M Castaño, Paige Lewis, Angela Barrett, Oidda I Museru, Ormarys Castellanos, Philip S LaRussa
INTRODUCTION: The feasibility and accuracy of text messaging to monitor events after influenza vaccination throughout pregnancy and the neonatal period has not been studied, but may be important for seasonal and pandemic influenza vaccines and future maternal vaccines. METHODS: This prospective observational study was conducted during 2013-2014 and analyzed in 2015-2016. Enrolled pregnant women receiving inactivated influenza vaccination at a gestational age <20 weeks were sent text messages intermittently through participant-reported pregnancy end to request fever, health events, and neonatal outcomes...
May 2, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28483192/no-association-between-influenza-vaccination-during-pregnancy-and-adverse-birth-outcomes
#18
Ousseny Zerbo, Sharareh Modaressi, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Bruce Fireman, Nicola P Klein, Roger Baxter
BACKGROUND: Pregnant women are recommended to receive inactivated influenza vaccination anytime during pregnancy. Studies have investigated the impact of influenza vaccination during pregnancy on birth outcomes and results on preterm birth have been inconsistent. METHODS: We conducted a retrospective cohort study among children born at a gestational age≥24weeks from January 1, 2010 to December 31, 2015 at Kaiser Permanente Northern California facilities (KPNC)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28480255/risk-factors-for-influenza-associated-severe-acute-respiratory-illness-hospitalization-in-south-africa-2012-2015
#19
Stefano Tempia, Sibongile Walaza, Jocelyn Moyes, Adam L Cohen, Claire von Mollendorf, Florette K Treurnicht, Marietjie Venter, Marthi Pretorius, Orienka Hellferscee, Senzo Mtshali, Mpho Seleka, Akhona Tshangela, Athermon Nguweneza, Johanna M McAnerney, Nicole Wolter, Anne von Gottberg, Halima Dawood, Ebrahim Variava, Shabir A Madhi, Cheryl Cohen
BACKGROUND: Data on risk factors for influenza-associated hospitalizations in low- and middle-income countries are limited. METHODS: We conducted active syndromic surveillance for hospitalized severe acute respiratory illness (SARI) and outpatient influenza-like illness (ILI) in 2 provinces of South Africa during 2012-2015. We compared the characteristics of influenza-positive patients with SARI to those with ILI to identify factors associated with severe disease requiring hospitalization, using unconditional logistic regression...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28474629/epidemiological-clinical-profile-of-influenza-a-h1n1-2009-virus-infections-during-2015-epidemic-in-rajasthan
#20
Bharti Malhotra, Ruchi Singh, Pratibha Sharma, Deepa Meena, Jyoti Gupta, Aditya Atreya, B R Meena
BACKGROUND & OBJECTIVES: Pandemic influenza A (H1N1) 2009 virus emerged in 2009 and caused pandemic with high morbidity and mortality in India and worldwide. The number of H1N1-positive cases varied in different years in Rajasthan. The objective of the study was to present the epidemiological profile of pandemic influenza A (H1N1) 2009 virus cases in Rajasthan from January to March 2015. METHODS: A retrospective descriptive, record-based analysis of suspected and confirmed cases of pandemic influenza A (H1N1) 2009 virus infection in Rajasthan, India, from January to March 2015 was performed...
December 2016: Indian Journal of Medical Research
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