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Frailty in the elderly

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https://www.readbyqxmd.com/read/28527727/patient-outcomes-following-lower-leg-major-amputations-for-peripheral-arterial-disease-a-series-review
#1
Susan Monaro, Sandra West, Janice Gullick
INTRODUCTION: Despite improvements in revascularization, major amputation remains a significant part of the case-mix in vascular surgical units. These patients tend to be elderly with complex pathology, resulting in poor outcomes and longer lengths of stay (LOS). AIM: This series review provides a description of the patient complexities and outcomes in an Australian cohort undergoing major lower limb amputation for peripheral arterial disease. METHOD: Medical records coded for major amputation between July 2012 and June 2013 in an Australian government funded, tertiary hospital were retrospectively reviewed and descriptively analyzed...
June 2017: Journal of Vascular Nursing: Official Publication of the Society for Peripheral Vascular Nursing
https://www.readbyqxmd.com/read/28527626/the-impact-of-economic-conditions-on-the-disablement-process-a-markov-transition-approach-using-share-data
#2
Y Arrighi, T Rapp, N Sirven
A growing number of studies underline the relationship between socioeconomic status and health at older ages. Following that literature, we explore the impact of economic conditions on changes in functional health overtime. Frailty, a state of physiological instability, has been identified in the public health literature as a candidate for disability prevention but received little attention from health economists. Using SHARE panel data, respondents aged 50 and over from ten European countries were categorised as robust, frail and dependent...
May 10, 2017: Health Policy
https://www.readbyqxmd.com/read/28525586/prevalence-and-correlates-of-frailty-among-community-dwelling-chinese-older-adults-the-china-health-and-retirement-longitudinal-study
#3
Chenkai Wu, Ellen Smit, Qian-Li Xue, Michelle C Odden
Background.: Frailty is an age-related clinical syndrome of decreased resilience to stressors and is associated with numerous adverse outcomes. Although there is preponderance of literature on frailty in developed countries, limited investigations have been conducted in less developed regions including China-a country that has the world's largest aging population. We examined frailty prevalence in China by socio-demographics and geographic region, and investigated correlates of frailty...
May 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28513119/low-borderline-levels-of-serum-vitamin-b12-may-predict-cognitive-decline-in-elderly-hip-fracture-patients
#4
Eliyahu H Mizrahi, Emilia Lubart, Arthur Leibovitz
BACKGROUND: The progression from cognitive impairment to dementia is a multifactorial process that involves genetic and environmental factors. Vitamin B12 deficiency can be an important factor in the progress from cognitive decline to dementia. OBJECTIVES: To examine the relationship between borderline low level of vitamin B12 (≤ 350 pg/ml) and cognitive decline among a group of elderly hip fracture patients. METHODS: This retrospective chart review study was conducted in a geriatric rehabilitation ward of a university-affiliated referral hospital...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28510786/the-impact-of-frailty-on-noninvasive-mechanical-ventilation-in-elderly-medical-intensive-care-unit-patients
#5
Iskender Kara, F Yildirim, A Zerman, Z Gullu, N Boyaci, B B Aydogan, U Gaygisiz, K Gonderen, G Arik, M Turkoglu, M Aydogdu, G Aygencel, Z Ulger, G Gursel
AIM: Many factors affecting noninvasive ventilation (NIV) in critically ill patients have been reported in the literature, but there is no study about the effect of frailty. With this study, the frailty prevalence was evaluated with two different frailty scores among the NIV population of a medical intensive care unit (ICU). Besides, the impact of frailty on NIV success and mortality and its association with NIV application problems were evaluated. METHOD: A prospective observational cohort study was performed on patients who were over 50 years of age and assigned to NIV due to hypercapnic respiratory failure...
May 16, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28505140/self-management-group-exercise-extends-healthy-life-expectancy-in-frail-community-dwelling-older-adults
#6
Minoru Yamada, Hidenori Arai
Preventing frailty and its adverse health outcomes is crucial in countries with a large elderly population, such as Japan. Since the long-term care insurance (LTCI) system was launched, the number of certified older adults with LTCI service requirement has continued to increase. This is a serious problem, because the LTCI service requirement certification is equivalent to disability. The aim of this study was to evaluate the effect of a self-management group intervention on new LTCI service requirement certifications in community-dwelling older adults in Japan...
May 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28496545/c-reactive-protein-and-frailty-in-the-elderly-a-literature-review
#7
REVIEW
Dimitrios Velissaris, Nikolaos Pantzaris, Ioanna Koniari, Nikolaos Koutsogiannis, Vasilios Karamouzos, Ioanna Kotroni, Anastasia Skroumpelou, John Ellul
Chronic inflammation is a well-established background process in many age-related diseases. Many recent studies investigate the use of various inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6, and interleukin-1 as predictors of physical and cognitive performance among elders. The phenotype of frailty has also been associated with underlying inflammatory mechanisms. The aim of this article was to review the literature referring to the correlation of CRP serum levels and frailty in older individuals...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28487242/oxidative-stress-genomic-features-and-dna-repair-in-frail-elderly-a-systematic-review
#8
REVIEW
María Sánchez-Flores, Diego Marcos-Pérez, Solange Costa, João Paulo Teixeira, Stefano Bonassi, Eduardo Pásaro, Blanca Laffon, Vanessa Valdiglesias
Frailty is an emerging geriatric syndrome characterized by higher vulnerability to stressors, with an increased risk of adverse health outcomes such as mortality, morbidity, disability, hospitalization, and institutionalization. Although it is generally recognized to have a biological basis, no particular biological trait has been consistently associated to frailty status so far. In this work, epidemiological studies evaluating association of frailty status with alterations at cellular level - namely oxidative stress, genomic instability and DNA damage and repair biomarkers -were revised and compared...
May 6, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28478840/alzheimer-s-disease-and-other-neurodegenerative-diseases-may-be-due-to-nutritional-deficiencies-secondary-to-unrecognized-exocrine-pancreatic-insufficiency
#9
Steven R Brenner
Alzheimer's disease (AD) may be related to nutritional deficiencies from exocrine pancreatic insufficiency (EPI) with mal-absorption of essential nutrients, vitamins and minerals. EPI occurs in about twenty percent of the elderly population, sometimes without obvious symptoms, a number similar to the incidence of AD. Other Neurological degenerative diseases with potential nutritional components such as Parkinson's disease, frailty of age and Multiple Sclerosis, a disease with increased activity from vitamin D deficiency, may also be related to untreated exocrine pancreatic insufficiency causing impaired absorption of essential dietary elements...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28475664/dynamical-resilience-indicators-in-time-series-of-self-rated-health-correspond-to-frailty-levels-in-older-adults
#10
Sanne M W Gijzel, Ingrid A van de Leemput, Marten Scheffer, Mattia Roppolo, Marcel G M Olde Rikkert, René J F Melis
Background: We currently still lack valid methods to dynamically measure resilience for stressors before the appearance of adverse health outcomes that hamper well-being. Quantifying an older adult's resilience in an early stage would aid complex decision-making in health care. Translating complex dynamical systems theory to humans, we hypothesized that three dynamical indicators of resilience (variance, temporal autocorrelation, and cross-correlation) in time series of self-rated physical, mental, and social health were associated with frailty levels in older adults...
May 5, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28473281/linear-and-nonlinear-analysis-of-postural-control-in-frailty-syndrome
#11
Verena de Vassimon-Barroso, Aparecida Maria Catai, Marcele Stephanie De Souza Buto, Alberto Porta, Anielle Cristhine De Medeiros Takahashi
BACKGROUND: Adaptive postural control can be impaired in the presence of frailty syndrome, given that this condition causes homeostatic dysregulation in physiological systems. OBJECTIVES: To compare the center of pressure (CoP) displacements of non-frail, pre-frail, and frail elderly subjects in the standing position before and after postural transition of sitting and rising from a chair, using linear and nonlinear methods. METHODS: Forty-two elderly subjects were divided into 3 groups: non-frail (n=15), pre-frail (n=15), and frail (n=12)...
April 9, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28471943/clinical-implications-of-aging-with-hiv-infection-perspectives-and-the-future-medical-care-agenda
#12
Giovanni Guaraldi, Frank J Palella
: The increasing number of aging HIV-infected (HIV+) persons comprises a unique population at risk for illnesses and syndromes traditionally associated with the elderly. As a result, similar to the current need for primary care providers to manage chronic noninfectious comorbidities among aging persons with well controlled HIV infection, HIV clinical care will need to routinely involve geriatric medicine in a new HIV-geriatric discipline. The objective of this article is to provide a conceptual framework in which HIV and geriatric management considerations for healthcare professionals caring for HIV+ persons are integrated...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28471574/frailty-transitions-in-community-dwelling-older-people
#13
Netta Bentur, Shelley A Sternberg, Jennifer Shuldiner
BACKGROUND: Frailty is a dynamic process with transitions over time. OBJECTIVES: To examine frailty transitions and their relationship to utilization of health services. METHODS: Frailty status using the Vulnerable Elders Survey (VES-13) was determined for 608 community-dwelling older people interviewed in a 2008 national survey and for 281 re-interviewed in 2014. The effect of frailty on death 6 years later was assessed using Cox proportional hazards analysis...
August 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28463202/gait-velocity-and-chair-sit-stand-sit-performance-improves-current-frailty-status-identification
#14
Nora Millor, Pablo Lecumberri, Marisol Gomez, Alicia Martinez-Ramirez, Ion Martinikorena, Leocadio Rodriguez-Manas, Francisco Garcia Garcia, Mikel Izquierdo
Frailty is characterized by a loss of functionality and is expected to affect 9.9% of people aged 65 and over. Here, current frailty classification is compared to a collection of selected kinematic parameters. A total of 718 elderly subjects (319 males and 399 females; age: 75.4 ± 6.1 years), volunteered to participate in this study and were classified according to Fried´s criteria. Both the 30-s chair stand test (CST) and the 3-m walking test were performed and a set of kinematic parameters were obtained from a single inertial unit...
April 27, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28455830/the-iatrogenic-triad-polypharmacy-drug-drug-interactions-and-potentially-inappropriate-medications-in-older-adults
#15
Priscila Horta Novaes, Danielle Teles da Cruz, Alessandra Lamas Granero Lucchetti, Isabel Cristina Gonçalves Leite, Giancarlo Lucchetti
Background The elderly population is often in continuous use of several medications and is more subject to the "iatrogenic triad" of polypharmacy, potentially inappropriate medication use and drug-drug interactions. However, few studies have investigated these three factors concomitantly. Purpose To assess the prevalence and inter-relationship of potentially inappropriate medication (PIM) use, polypharmacy and drug-drug interactions in older adults, together with their associated factors. Setting city of Juiz de Fora, Brazil...
April 28, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28436194/impact-of-living-arrangements-on-clinical-outcomes-among-older-patients-with-dementia-or-cognitive-impairment-admitted-to-the-geriatric-evaluation-and-management-unit-in-taiwan
#16
Cheng-Hao Hung, Ting-Ching Tang, Chih-Jen Wang, Li-Kuo Liu, Li-Ning Peng, Liang-Kung Chen
AIM: To evaluate the impact of living arrangements on mortality and functional decline among older patients with dementia or cognitive impairment after discharge from a geriatric evaluation and management unit (GEMU) in Taiwan. METHODS: The present retrospective cohort study used data from the Veteran Affairs Comprehensive Geriatric Assessment from January 2015 to May 2016 for analysis. Data of patients aged 65 years and older with dementia or cognitive impairment at admission to the GEMU of Taipei Veterans General Hospital during the study period were retried for study...
April 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28427345/variation-in-gp-decisions-on-antihypertensive-treatment-in-oldest-old-and-frail-individuals-across-29-countries
#17
Sven Streit, Marjolein Verschoor, Nicolas Rodondi, Daiana Bonfim, Robert A Burman, Claire Collins, Gerasimovska Kitanovska Biljana, Sandra Gintere, Raquel Gómez Bravo, Kathryn Hoffmann, Claudia Iftode, Kasper L Johansen, Ngaire Kerse, Tuomas H Koskela, Sanda Kreitmayer Peštić, Donata Kurpas, Christian D Mallen, Hubert Maisoneuve, Christoph Merlo, Yolanda Mueller, Christiane Muth, Marija Petek Šter, Ferdinando Petrazzuoli, Thomas Rosemann, Martin Sattler, Zuzana Švadlenková, Athina Tatsioni, Hans Thulesius, Victoria Tkachenko, Peter Torzsa, Rosy Tsopra, Tuz Canan, Rita P A Viegas, Shlomo Vinker, Margot W M de Waal, Andreas Zeller, Jacobijn Gussekloo, Rosalinde K E Poortvliet
BACKGROUND: In oldest-old patients (>80), few trials showed efficacy of treating hypertension and they included mostly the healthiest elderly. The resulting lack of knowledge has led to inconsistent guidelines, mainly based on systolic blood pressure (SBP), cardiovascular disease (CVD) but not on frailty despite the high prevalence in oldest-old. This may lead to variation how General Practitioners (GPs) treat hypertension. Our aim was to investigate treatment variation of GPs in oldest-olds across countries and to identify the role of frailty in that decision...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28423084/immune-system-dysfunction-in-the-elderly
#18
Eduardo Fuentes, Manuel Fuentes, Marcelo Alarcón, Iván Palomo
Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment...
January 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28419681/oral-mycobiome-in-community-dwelling-elderly-and-its-relation-to-oral-and-general-health-conditions
#19
Myrna Nurlatifah Zakaria, Michiko Furuta, Toru Takeshita, Yukie Shibata, Rini Sundari, Nobuoki Eshima, Toshiharu Ninomiya, Yoshihisa Yamashita
OBJECTIVE: Oral fungal infection is generally associated with dysbiosis related to antibiotic use, immunodeficiency, or frailty. However, fungal colonization in a typical population without apparent symptoms, and its associated conditions are poorly understood. In this study, oral fungal colonization in community-dwelling and independently living elderly populations was evaluated and factors affecting fungal colonization were analyzed. SUBJECTS AND METHODS: The subjects (410; 181 males and 229 females) were 75-99 years of age; those under prior antibiotic use were excluded...
April 18, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28413364/delivering-integrated-care-to-the-frail-elderly-the-impact-on-professionals-objective-burden-and-job-satisfaction
#20
Benjamin Janse, Robbert Huijsman, Ruben Dennis Maurice de Kuyper, Isabelle Natalina Fabbricotti
BACKGROUND: The impact of integrated working on professionals' objective burden and job satisfaction was examined. An evidence-based intervention targeting frail elderly patients was implemented in the Walcheren region of the Netherlands in 2010. The intervention involved the primary care practice as a single entry point, and included proactive frailty screening, a comprehensive assessment of patient needs, case management, multidisciplinary teams, care plans and protocols, task delegation and task specialisation, a shared information system, a geriatric care network and integrated funding...
August 17, 2016: International Journal of Integrated Care
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