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atrial natriuretic peptide

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https://www.readbyqxmd.com/read/27898523/role-of-corin-in-the-regulation-of-blood-pressure
#1
Hui Li, Yue Zhang, Qingyu Wu
PURPOSE OF REVIEW: Corin is a transmembrane protease that activates atrial natriuretic peptide (ANP), an important hormone in regulating salt-water balance and blood pressure. This review focuses on the regulation of corin function and potential roles of corin defects in hypertensive, heart, and renal diseases. RECENT FINDINGS: Proprotein convertase subtilisin/kexin-6 has been identified as a primary enzyme that converts zymogen corin to an active protease. Genetic variants that impair corin intracellular trafficking, cell surface expression, and zymogen activation have been found in patients with hypertension, cardiac hypertrophy, and pre-eclampsia...
November 24, 2016: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/27896626/cheyne-stokes-respiration-during-wakefulness-in-patients-with-chronic-heart-failure
#2
Wolfram Grimm, Karl Kesper, Werner Cassel, Nina Timmesfeld, Olaf Hildebrandt, Ulrich Koehler
PURPOSE: Cheyne-Stokes respiration (CSR) during sleep has been studied extensively in patients with chronic heart failure (CHF). Prevalence and prognostic significance of CSR during wakefulness in CHF, however, are largely unknown. METHODS: CSR during wakefulness with an apnea-hypopnea cut-off ≥5/h and moderate to severe CSR with an apnea-hypopnea cutoff ≥15/h were analyzed using polysomnographic recordings in 267 patients with stable CHF with reduced left ventricular (LV) ejection fraction at our institution...
November 28, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27884747/novel-function-of-%C3%AE-1d-l-type-calcium-channel-in-the-atria
#3
Ujala Srivastava, Ademuyiwa S Aromolaran, Frank Fabris, Deana Lazaro, John Kassotis, Yongxia Qu, Mohamed Boutjdir
Ca entry through atrial L-type Calcium channels (α1C and α1D) play an important role in muscular contraction, regulation of gene expression, and release of hormones including atrial natriuretic peptide (ANP), and brain natriuretic peptide (BNP). α1D Ca channel is exclusively expressed in atria, and has been shown to play a key role in the pathogenesis of atrial fibrillation. Recent data have shown that the small conductance calcium-activated potassium channel, SK4 is also atrial specific and also contributes prominently to the secretion of ANP and BNP...
November 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27884008/left-ventricular-plication-reduces-wall-stress-and-cardiomyocyte-hypertrophy-in-a-rat-model-of-ischemic-cardiomyopathy
#4
Hidetsugu Asai, Yasushige Shingu, Tomoji Yamakawa, Haruki Niwano, Satoru Wakasa, Tomonori Ooka, Hiroki Kato, Tsuyoshi Tachibana, Yoshiro Matsui
BACKGROUND: The indications of left-ventricular plication (LVP) are controversial, although several studies have reported favorable outcomes in heart failure patients. The aim of this study was to assess left-ventricular (LV) wall stress and myocardial remodeling after LVP in a rat model of myocardial infarction (MI). METHODS: Sixteen rats underwent LVP by excluding the LV anterior wall scar 4 weeks after ligation of the left anterior descending artery. After 4 weeks, LV wall stress was assessed using transthoracic echocardiography and an LV catheter...
November 25, 2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
https://www.readbyqxmd.com/read/27876310/impact-of-atrial-natriuretic-peptide-value-for-predicting-paroxysmal-atrial-fibrillation-in-ischemic-stroke-patients
#5
Hiroshi Shiroto, Hirofumi Tomita, Joji Hagii, Norifumi Metoki, Ayaka Fujita, Takaatsu Kamada, Koki Takahashi, Shin Saito, Satoko Sasaki, Hiroyasu Hitomi, Satoshi Seino, Yoshiko Baba, Takamitsu Uchizawa, Manabu Iwata, Shigeo Matsumoto, Minoru Yasujima, Ken Okumura
INTRODUCTION: The impact of atrial natriuretic peptide (ANP) value for predicting paroxysmal atrial fibrillation (pAF) in ischemic stroke patients remains uncertain. METHODS: The consecutive 222 ischemic stroke patients (median 77 [IQR 68-83] years old, 93 females) within 48 hours after onset were retrospectively studied. Plasma ANP and brain natriuretic peptide (BNP) levels were simultaneously measured at admission. Of all, 158 patients had no evidence of atrial fibrillation (AF) (sinus rhythm [SR] group), 25 patients had pAF (pAF group), and the other 39 patients had chronic AF (cAF group)...
November 18, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27875739/plasma-levels-of-atrial-and-brain-natriuretic-peptides-in-apparently-healthy-subjects-effects-of-sex-age-and-hemoglobin-concentration
#6
Mareomi Hamada, Yuji Shigematsu, Masayuki Takezaki, Shuntaro Ikeda, Akiyoshi Ogimoto
BACKGROUND: To examine whether the use of one value of natriuretic peptides to define "normal" is appropriate in all individuals, and to assess the influence of sex, age, and other variables on atrial and brain natriuretic peptides (ANP, BNP) levels. METHODS AND RESULTS: A total of 1375 apparently healthy people (women:155, men:1220), aged 18-70years were enrolled. Both ANP and BNP levels were higher in women than in men (ANP: 12.50±6.82pg/mL vs 8.18±4.19pg/mL; BNP: 9...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27871468/increased-levels-of-soluble-corin-in-pre-eclampsia-and-fetal-growth-restriction
#7
Jun Miyazaki, Haruki Nishizawa, Asuka Kambayashi, Mayuko Ito, Yoshiteru Noda, Sumire Terasawa, Takema Kato, Hironori Miyamura, Kazuya Shiogama, Takao Sekiya, Hiroki Kurahashi, Takuma Fujii
Atrial natriuretic peptide is biologically activated by the atrial natriuretic peptide-converting enzyme, corin, and has an important role in regulating blood pressure. We detected elevated serum corin levels in women with pre-eclampsia. Interestingly, the serum corin levels were also found to be elevated in pregnancies with a related disorder, unexplained fetal growth restriction (FGR) without hypertension, suggesting that this phenomenon is not simply a response to maternal hypertension. CORIN mRNA levels were not elevated in placentas from pre-eclampsia or unexplained FGR cases...
December 2016: Placenta
https://www.readbyqxmd.com/read/27865997/homogentisic-acid-induces-aggregation-and-fibrillation-of-amyloidogenic-proteins
#8
Daniela Braconi, Lia Millucci, Andrea Bernini, Ottavia Spiga, Pietro Lupetti, Barbara Marzocchi, Neri Niccolai, Giulia Bernardini, Annalisa Santucci
BACKGROUND: Alkaptonuria (AKU) is an ultra-rare inborn error of metabolism characterized by homogentisic acid (HGA) accumulation due to a deficient activity of the homogentisate 1.2-dioxygenase (HGD) enzyme. This leads to the production of dark pigments that are deposited onto connective tissues, a condition named 'ochronosis' and whose mechanisms are not completely clear. Recently, the potential role of hitherto unidentified proteins in the ochronotic process was hypothesized, and the presence of Serum Amyloid A (SAA) in alkaptonuric tissues was reported, allowing the classification of AKU as a novel secondary amyloidosis...
November 16, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27860152/n-terminal-pro-brain-natriuretic-peptide-is-a-useful-marker-to-identify-latent-heart-failure-patients-in-older-adults-in-a-rural-outpatient-clinic
#9
Kosuke Hamagawa, Toru Kubo, Kotaro Nishimura, Yuichi Baba, Takayoshi Hirota, Naohito Yamasaki, Hiroaki Kitaoka
AIM: Although measurement of natriuretic peptides including N-terminal pro-brain natriuretic peptide (NT-proBNP) has been recommended for identifying heart failure (HF) patients, the prevalence of elderly patients with latent HF who are attending an outpatient clinic is unknown. METHODS: We measured NT-proBNP levels in 393 patients (aged 75 ± 9 years) in a rural outpatient clinic. Patients with a diagnosis of heart disease were excluded. The patients were divided into two groups by the values of NT-proBNP: high NT-proBNP group (>400 pg/mL) and low NT-proBNP group (≤400 pg/mL) according to Japanese guidelines...
November 17, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27855811/heart-failure-with-preserved-ejection%C3%A2-fraction-and%C3%A2-atrial-fibrillation-vicious-twins
#10
REVIEW
Dipak Kotecha, Carolyn S P Lam, Dirk J Van Veldhuisen, Isabelle C Van Gelder, Adriaan A Voors, Michiel Rienstra
Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) are age-related conditions that are increasing in prevalence, commonly coexist, and share clinical features. This review provides a practical update on the epidemiology, pathophysiology, diagnosis, and management of patients with concomitant HFpEF and AF. Epidemiological studies highlight the close and complex links between HFpEF and AF, the shared risk factors, the high AF occurrence in the natural history of HFpEF, and the independent contribution of each condition to poor outcomes...
November 15, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27853882/the-protective-effect-of-human-atrial-natriuretic-peptide-on-renal-damage-during-cardiac-surgery
#11
Takahiro Moriyama, Shintaro Hagihara, Toko Shiramomo, Misaki Nagaoka, Shohei Iwakawa, Yuichi Kanmura
PURPOSE: Acute kidney injury (AKI) is one of the critical complications after cardiac surgery. In the kidney, angiotensin II (Ang II) is formed by independent mechanisms, and activity of the intrarenal renin-angiotensin-aldosterone (RAAS) system contributes to the progression of kidney damage. Although atrial natriuretic peptide (ANP) exerts protective effects against renal injury by inhibiting the RAAS, the mechanisms of this effect have not been completely clarified. We investigated how human ANP (hANP) could prevent renal damage induced by cardiopulmonary bypass...
November 16, 2016: Journal of Anesthesia
https://www.readbyqxmd.com/read/27847152/endurance-exercise-induced-changes-in-bnp-concentrations-in-cardiovascular-patients-versus-healthy-controls
#12
Vincent L Aengevaeren, Maria T E Hopman, Dick H J Thijssen, Roland R van Kimmenade, Menko-Jan de Boer, Thijs M H Eijsvogels
BACKGROUND: Healthy athletes demonstrated increased B-type natriuretic peptide (BNP) concentrations following exercise, but it is unknown whether these responses are exaggerated in individuals with cardiovascular risk factors (CVRF) or disease (CVD). We compared exercise-induced increases in BNP between healthy controls (CON) and individuals with CVRF or CVD. Furthermore, we aimed to identify predictors for BNP responses. METHODS: Serum BNP concentrations were measured in 191 participants (60±12yrs) of the Nijmegen Marches before (baseline) and immediately after 4 consecutive days of walking exercise (30-50km/day)...
November 8, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27836303/prevalence-and-correlates-of-left-ventricular-diastolic-dysfunction-and-heart-failure-with-preserved-ejection-fraction-in-elderly-community-residents
#13
Xiaotong Cui, Jingmin Zhou, Xuejuan Jin, Jun Zhou, Michael Fu, Kai Hu, Aijun Sun, Junbo Ge
BACKGROUND: Left ventricular diastolic dysfunction (LVDD) is closely related to heart failure with preserved ejection fraction (HFpEF), while the prevalence and correlates of either LVDD or HFpEF in elderly population remain largely unknown. METHODS: The study was performed in 1274 community residents (769 women, aged ≥65years) who participated in the Shanghai Heart Health Study. Demographic, laboratory and echocardiographic data were obtained to analyze correlates of LVDD and HFpEF using univariate and multivariate Logistic analysis...
October 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27833552/hydrogen-h2-inhibits-isoproterenol-induced-cardiac-hypertrophy-via-antioxidative-pathways
#14
Yaxing Zhang, Jingting Xu, Zhiyuan Long, Chen Wang, Ling Wang, Peng Sun, Ping Li, Tinghuai Wang
Background and Purpose: Hydrogen (H2) has been shown to have a strong antioxidant effect on preventing oxidative stress-related diseases. The goal of the present study is to determine the pharmacodynamics of H2 in a model of isoproterenol (ISO)-induced cardiac hypertrophy. Methods: Mice (C57BL/6J; 8-10 weeks of age) were randomly assigned to four groups: Control group (n = 10), ISO group (n = 12), ISO plus H2 group (n = 12), and H2 group (n = 12). Mice received H2 (1 ml/100g/day, intraperitoneal injection) for 7 days before ISO (0...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27832993/the-role-of-natriuretic-peptides-in-diabetes-and-its-complications
#15
REVIEW
Ying Feng, Da Wang, Huili Bi, Huijuan Zhang
This review aimed to summarize recent findings on the role of natriuretic peptides (NPs) in diabetes and its important complications. Although the treatment of diabetes mellitus has benefited from recent advances, aggressive glycemic control can increase the risk of hypoglycemia and weight gain. Therefore, innovative therapies are required to address this issue. Natriuretic peptides (NPs) may have such novel therapeutic potential. NPs comprise a family of structurally related peptides, including atrial, brain, C-type, and dendroaspis...
November 7, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27826974/can-n-terminal-pro-b-type-natriuretic-peptide-neutrophil-to-lymphocyte-ratio-c-reactive-protein-help-to-predict-short-and-long-term-mortality
#16
I Ozmen, Z Karakurt, C Salturk, F Kargin, H B Takir, E Aksoy, R Sari, E Celik, E A Tuncay, E Yildirim, O Y Mocin, N Adiguzel, S Oztas, S Gungor, G Gungor
BACKGROUND: There is limited data about ICU, short and long-term mortality prediction of severe CAP with neutrophil-to-lymphocyte ratio (NLR): N-terminal proB- type natriuretic peptide (NT-proBNP): C-reactive protein (CRP). AIM: Besides the known severity indexes of ICU, can NLR, NT-proBNP, CRP predict ICU, short and long term mortality? METHODS: A retrospective cohort study was carried out in a level III ICU of a tertiary training hospital for chest diseases and thoracic surgery...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27825364/mid-regional-pro-adrenomedullin-mr-proadm-a-marker-of-positive-fluid-balance-in-critically-ill-patients-results-of-the-envol-study
#17
Bernard Vigué, Pierre-Etienne Leblanc, Frédérique Moati, Eric Pussard, Hussam Foufa, Aurore Rodrigues, Samy Figueiredo, Anatole Harrois, Jean-Xavier Mazoit, Homa Rafi, Jacques Duranteau
BACKGROUND: The optimal control of blood volume without fluid overload is a main challenge in the daily care of intensive care unit (ICU) patients. Accordingly this study focused on the identification of biomarkers to help characterize fluid overload status. METHODS: Sixty-seven patients were studied from ICU admission to day 7 (D7). Blood and urine samples were taken daily and sodium and water balance strictly calculated resulting in a total cumulative assessment of ∆Na(+) and ∆H2O...
November 9, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27813305/global-left-atrial-failure-in-heart-failure
#18
REVIEW
Filippos Triposkiadis, Burkert Pieske, Javed Butler, John Parissis, Gregory Giamouzis, John Skoularigis, Dirk Brutsaert, Harisios Boudoulas
The left atrium plays an important role in the maintenance of cardiovascular and neurohumoral homeostasis in heart failure. However, with progressive left ventricular dysfunction, left atrial (LA) dilation and mechanical failure develop, which frequently culminate in atrial fibrillation. Moreover, LA mechanical failure is accompanied by LA endocrine failure [deficient atrial natriuretic peptide (ANP) processing-synthesis/development of ANP resistance) and LA regulatory failure (dominance of sympathetic nervous system excitatory mechanisms, excessive vasopressin release) contributing to neurohumoral overactivity, vasoconstriction, and volume overload (global LA failure)...
November 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27811208/application-of-biomarkers-for-risk-stratification-in-patients-with-atrial-fibrillation
#19
REVIEW
Ziad Hijazi, Jonas Oldgren, Agneta Siegbahn, Lars Wallentin
BACKGROUND: Atrial fibrillation is the most common sustained arrhythmia and an important contributor to cardiovascular morbidity and mortality. Several strategies have been proposed for prediction of outcomes and individualization of treatments to better balance the benefits of stroke prevention and risks of bleeding during anticoagulation. CONTENT: The availability of analytically more specific and sensitive methods to measure circulating biomarkers of cellular and organ stress and dysfunction has led to testing of their utility in several cardiovascular conditions...
November 3, 2016: Clinical Chemistry
https://www.readbyqxmd.com/read/27809950/effects-of-prenatal-bisphenol-a-exposure-and-postnatal-overfeeding-on-cardiovascular-function-in-female-sheep
#20
S M J MohanKumar, T D Rajendran, A K Vyas, V Hoang, N Asirvatham-Jeyaraj, A Veiga-Lopez, N B Olivier, V Padmanabhan, P S MohanKumar
Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effects of prenatal BPA treatment and its interaction with postnatal overfeeding on the cardiovascular system. Pregnant sheep were given daily subcutaneous injections of corn oil (control) or BPA (0.5 mg/kg/day in corn oil) from day 30 to day 90 of gestation. A subset of female offspring of these dams were overfed to increase body weight to ~30% over that of normal fed controls...
November 4, 2016: Journal of Developmental Origins of Health and Disease
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