Xiao Ma, Seethalakshmi R Iyer, Xiaoyu Ma, Shawn H Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante G Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H Chen, Carlos M Ferrario, S Jeson Sangaralingham, John C Burnett
The natriuretic peptide system (NPS) and renin-angiotensin-aldosterone system (RAAS) function oppositely at multiple levels. While it has long been suspected that angiotensin II (ANGII) may directly suppress NPS activity, no clear evidence to date supports this notion. This study was designed to systematically investigate ANGII-NPS interaction in humans, in vivo, and in vitro. Circulating atrial, b-type, and c-type natriuretic peptides (ANP, BNP, CNP), cyclic guanosine monophosphate (cGMP), and ANGII were simultaneously investigated in 128 human subjects...
May 10, 2023: International Journal of Molecular Sciences