keyword
https://read.qxmd.com/read/37560770/impact-of-sleep-on-chronobiology-of-micturition-among-healthy-older-adults
#21
JOURNAL ARTICLE
Shachi Tyagi, Neil M Resnick, Becky D Clarkson, Gehui Zhang, Robert T Krafty, Subashan Perera, Arohan R Subramanya, Daniel J Buysse
Nocturia (waking to void) is prevalent among older adults. Disruption of the well-described circadian rhythm in urine production with higher nighttime urine output is its most common cause. In young adults, their circadian rhythm is modulated by the 24-hour secretory pattern of hormones that regulate salt and water excretion; including antidiuretic hormone (ADH), renin, angiotensin, aldosterone, and atrial natriuretic peptide (ANP). The pattern of hormone secretion is less clear in older adults. We investigated the effect of sleep on the 24-hour secretion of these hormones in healthy older adults...
August 10, 2023: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/37449835/paradoxical-increase-in-global-longitudinal-strain-by-handgrip-exercise-despite-left-ventricular-diastolic-dysfunction
#22
JOURNAL ARTICLE
Ko Motoi, Hiroyuki Iwano, Suguru Ishizaka, Kosuke Nakamura, Yoji Tamaki, Hiroyuki Aoyagi, Masahiro Nakabachi, Shinobu Yokoyama, Hisao Nishino, Michito Murayama, Sanae Kaga, Toshihisa Anzai
BACKGROUND: Although global longitudinal strain (GLS) is recognized as a sensitive marker of intrinsic left ventricular (LV) dysfunction, its afterload dependency has also been pointed. We hypothesized that decrease in GLS during handgrip exercise could be more sensitive marker of intrinsic myocardial dysfunction. METHODS: Handgrip exercise-stress echocardiography was performed in 90 cardiovascular disease patients with preserved LV ejection fraction. LV diastolic function was graded according to the guidelines...
July 14, 2023: Echocardiography
https://read.qxmd.com/read/37417873/sex-based-differences-in-metabolic-protection-by-the-anp-genetic-variant-rs5068-in-the-general-population
#23
JOURNAL ARTICLE
Tomoko Ichiki, Valentina Cannone, Christopher G Scott, Seethalakshmi R Iyer, S Jeson Sangaralingham, Kent R Bailey, Jens P Goetze, Yoshihisa Tsuji, Richard J Rodeheffer, John C Burnett
BACKGROUND: Atrial (ANP) and b-type (BNP) natriuretic peptides are produced in the heart and secreted into the circulation. As hormones, both peptides activate the guanylyl cyclase receptor A (GC-A) playing a role in blood pressure regulation. A significant role for ANP and BNP includes favorable actions in metabolic homeostasis. Sex-based high prevalence of risk factors for cardiovascular disease in males compared to females is well-established, but sex-based differences on cardiometabolic protection have not been investigated in relation to ANP and BNP gene variants...
July 7, 2023: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/37401170/effect-of-sh2b1-on-glucose-metabolism-during-pressure-overload-induced-cardiac-hypertrophy-and-cardiac-dysfunction
#24
JOURNAL ARTICLE
Beilei Liu, Xuguang Liu, Shan Hu, Shuai Mao, Manqi Yang, Bin Wu, Gang Wu
This study mainly explored the effect and mechanism of Src homology 2 (SH2) B adaptor protein 1 (SH2B1) on cardiac glucose metabolism during pressure overload-induced cardiac hypertrophy and dysfunction. A pressure-overloaded cardiac hypertrophy model was constructed, and SH2B1-siRNA was injected through the tail vein. Haematoxylin and eosin (H&E) staining was used to detect myocardial morphology. ANP, BNP, β-MHC and the diameter of myocardial fibres were quantitatively measured to evaluate the degree of cardiac hypertrophy, respectively...
July 3, 2023: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/37377513/effects-of-mineralocorticoid-receptor-antagonists-in-early-stage-heart-failure-with-preserved-ejection-fraction
#25
JOURNAL ARTICLE
Kazuki Kagami, Masaru Obokata, Tomonari Harada, Yuki Saito, Ayami Naito, Hidemi Sorimachi, Naoki Yuasa, Toshimitsu Kato, Naoki Wada, Takeshi Adachi, Hideki Ishii
BACKGROUND: Hospitalization with a first episode of heart failure (HF) is a serious event associated with poor clinical outcomes in HF with preserved ejection fraction (HFpEF). Identification of HFpEF via detection of elevated left ventricular filling pressure at rest or during exercise may allow early intervention. Benefits of treatment with mineralocorticoid receptor antagonists (MRAs) in established HFpEF have been reported, but use of MRAs is not well studied in early HFpEF without prior HF hospitalization...
May 2023: CJC open
https://read.qxmd.com/read/37324339/feasibility-study-of-intraoperative-pericardial-fluid-biomarkers-and-length-of-stay-after-cardiac-surgery
#26
JOURNAL ARTICLE
Lee A Goeddel, Ahmed Zaky, Inmaculada Aban, Chad Steele, James F George, Spencer J Melby, Louis J Dell'Italia
OBJECTIVE: Pericardial fluid biomarkers reflect the physiologic state of the myocardium. Previously, we showed a sustained increase in pericardial fluid biomarkers compared with blood in the 48 hours after cardiac surgery. We assess the feasibility of analyzing 9 common cardiac biomarkers from pericardial fluid collected during cardiac surgery and test a preliminary hypothesis of association between the most common biomarkers, troponin and brain natriuretic peptide, and length of stay after surgery...
June 2023: JTCVS techniques
https://read.qxmd.com/read/37298592/the-natriuretic-peptide-system-a-single-entity-pleiotropic-effects
#27
REVIEW
Vittoriano Della Corte, Gaetano Pacinella, Federica Todaro, Rosaria Pecoraro, Antonino Tuttolomondo
In the modern scientific landscape, natriuretic peptides are a complex and interesting network of molecules playing pleiotropic effects on many organs and tissues, ensuring the maintenance of homeostasis mainly in the cardiovascular system and regulating the water-salt balance. The characterization of their receptors, the understanding of the molecular mechanisms through which they exert their action, and the discovery of new peptides in the last period have made it possible to increasingly feature the physiological and pathophysiological role of the members of this family, also allowing to hypothesize the possible settings for using these molecules for therapeutic purposes...
June 1, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37242285/assessment-of-areca-nut-bioactivities-in-western-diet-induced-mice-nafld-model
#28
JOURNAL ARTICLE
Shuhan Yi, Keyu Chen, Kozue Sakao, Makoto Ikenaga, Yuanliang Wang, De-Xing Hou
The areca nut is often consumed as a chewing food in the Asian region. Our previous study revealed that the areca nut is rich in polyphenols with high antioxidant activity. In this study, we further assessed the effects and molecular mechanisms of the areca nut and its major ingredients on a Western diet-induced mice dyslipidemia model. Male C57BL/6N mice were divided into five groups and fed with a normal diet (ND), Western diet (WD), WD with areca nut extracts (ANE), areca nut polyphenols (ANP), and arecoline (ARE) for 12 weeks...
May 21, 2023: Nutrients
https://read.qxmd.com/read/37239899/evidence-for-angiotensin-ii-as-a-naturally-existing-suppressor-for-the-guanylyl-cyclase-a-receptor-and-cyclic-gmp-generation
#29
JOURNAL ARTICLE
Xiao Ma, Seethalakshmi R Iyer, Xiaoyu Ma, Shawn H Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante G Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H Chen, Carlos M Ferrario, S Jeson Sangaralingham, John C Burnett
The natriuretic peptide system (NPS) and renin-angiotensin-aldosterone system (RAAS) function oppositely at multiple levels. While it has long been suspected that angiotensin II (ANGII) may directly suppress NPS activity, no clear evidence to date supports this notion. This study was designed to systematically investigate ANGII-NPS interaction in humans, in vivo, and in vitro. Circulating atrial, b-type, and c-type natriuretic peptides (ANP, BNP, CNP), cyclic guanosine monophosphate (cGMP), and ANGII were simultaneously investigated in 128 human subjects...
May 10, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37223634/association-of-physiological-stress-markers-at-the-emergency-department-to-readmission-and-death-within-90-days-a-prospective-observational-study
#30
JOURNAL ARTICLE
Lee Ti Davidson, Ulf Martin Schilling, Hans J Arnqvist, Fredrik H Nystrom, Simona I Chisalita
BACKGROUND: Predicting the risk of readmission or death in patients at the emergency department (ED) is essential in identifying patients who would benefit the most from interventions. We aimed to explore the prognostic value of mid-regional proadrenomedullin (MR-proADM), mid-regional pro-atrial natriuretic peptide (MR-proANP), copeptin, and high-sensitivity troponin T (hs-TnT) to identify patients with a higher risk of readmission and death among patients presenting with chest pain (CP) and/or shortness of breath (SOB) in the ED...
2023: Upsala Journal of Medical Sciences
https://read.qxmd.com/read/37088761/-protective-effects-of-sphingosine-1-phosphate-s1p-on-hypertrophic-response-in-h9c2-cardiomyocytes
#31
JOURNAL ARTICLE
Hui Yan, Hu Zhao, Lun Li
OBJECTIVE: To investigate the effects of sphingosine-1-phosphate (S1P) on cardiac hypertrophic response in H9c2 cells. METHODS: H9c2 cells were randomly divided into four groups: normal control group, S1P (1 μmol/L) treated group, Phenylephrine (PE) (100 μmol/L) treated group, PE (100 μmol/L) treated group combined with S1P (1 μmol/L) treatment. Each group has 3 duplicated wells. After 24 hours, the size of H9c2 cells in each group was detected by Actin-Trakcer Green immunofluorescence staining...
September 2022: Chinese Journal of Applied Physiology
https://read.qxmd.com/read/37054600/nanopore-discrimination-and-sensitive-plasma-detection-of-multiple-natriuretic-peptides-the-representative-biomarker-of-human-heart-failure
#32
JOURNAL ARTICLE
Shaoxia Zhang, Yunjiao Wang, Dandan Song, Sarah Guan, Daming Zhou, Linyu Gong, Liyuan Liang, Xiyun Guan, Liang Wang
Natriuretic peptides can relieve cardiovascular stress and closely related to heart failure. Besides, these peptides also have preferable interactions of binding to cellular protein receptors, and subsequently mediate various physiology actions. Hence, detection of these circulating biomarkers could be evaluated as a predictor ("Gold standard") for rapid, early diagnosis and risk stratification in heart failure. Herein, we proposed a measurement to discriminate multiple natriuretic peptides via the peptide-protein nanopore interaction...
April 8, 2023: Biosensors & Bioelectronics
https://read.qxmd.com/read/37031522/alcohol-intake-masked-the-protective-effects-of-tea-consumption-against-all-cause-mortality-and-blood-pressure-progression-findings-from-chns-cohort-1993-2011
#33
JOURNAL ARTICLE
Weida Qiu, Anping Cai, Xiaoju Xiao, Shuang Xia, Liwen Li, Yingqing Feng
OBJECTIVES: Whether the protective effects of tea consumption interact with the status of alcohol consumption remains unknown. The present study aimed to investigate the relationship between tea consumption and mortality and blood pressure changes between alcohol consumers and non-consumers in a Chinese population. METHODS: This study was conducted with a cohort of 6387 participants from the China Health and Nutrition Survey data between 1993 and 2011. Group-based trajectory modeling was conducted to identify distinct tea consumption trajectories...
February 23, 2023: Nutrition
https://read.qxmd.com/read/37009194/natriuretic-peptides-as-biomarkers-narrative-review-and-considerations-in-cardiovascular-and-respiratory-dysfunctions
#34
REVIEW
Mohammad Samad, Sreekar Malempati, Carolina B A Restini
Natriuretic peptides (NPs) encompass a family of structurally related hormone/paracrine factors acting through the natriuretic peptide system regulating cell proliferation, vessel tone, inflammatory processes, neurohumoral pathways, fluids, and electrolyte balance. The three most studied peptides are atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-Type natriuretic peptide (CNP). ANP and BNP are the most relevant NPs as biomarkers for the diagnosis and prognosis of heart failure and underlying cardiovascular diseases, such as cardiac valvular dysfunction, hypertension, coronary artery disease, myocardial infarction, persistent arrhythmias, and cardiomyopathies...
March 2023: Yale Journal of Biology and Medicine
https://read.qxmd.com/read/36969608/identification-of-hypertrophy-modulating-cullin-ring-ubiquitin-ligases-in-primary-cardiomyocytes
#35
JOURNAL ARTICLE
Maximillian Fischer, Moritz Jakab, Marc N Hirt, Tessa R Werner, Stefan Engelhardt, Antonio Sarikas
Cullin-RING ubiquitin ligases (CRL) regulate numerous biological processes in the heart and have been implicated in regulating cardiac hypertrophy. This study aimed to identify novel hypertrophy-modulating CRLs in cardiomyocytes (CM). A functional genomic approach using siRNA-mediated depletion and automated microscopy was employed to screen for cell size-modulating CRLs in neonatal rat CM. Screening hits were confirmed by 3 H-isoleucine incorporation. Of 43 targets screened, siRNA-mediated depletion of Fbxo6, Fbxo45, and Fbxl14 resulted in decreased cell size, whereas depletion of Fbxo9, Fbxo25, Fbxo30, Fbxo32, Fbxo33, Cullin1, Roc1, Ddb1, Fbxw4, and Fbxw5 led to a markedly increased cell size under basal conditions...
2023: Frontiers in Physiology
https://read.qxmd.com/read/36937938/a-new-integrative-approach-to-assess-aortic-stenosis-burden-and-predict-objective-functional-improvement-after-tavr
#36
JOURNAL ARTICLE
Jose M de la Torre Hernandez, Gabriela Veiga Fernandez, Eyal Ben-Assa, Fermin Sainz Laso, Dae-Hyun Lee, Cristina Ruisanchez Villar, Piedad Lerena, Tamara Garcia Camarero, Jose M Cuesta Cosgaya, Victor Fradejas-Sastre, Mercedes Benito, Sergio Barrera, Maria T Garcia-Unzueta, Jonathan Brown, Aritz Gil Ongay, Javier Zueco, Jose A Vazquez de Prada, Elazer R Edelman
BACKGROUND: A non-negligible rate of patients undergoing transcatheter aortic valve replacement (TAVR) do not report symptomatic improvement or even die in the short-midterm. We sought to assess the degree of objective functional recovery after TAVR and its prognostic implications and to develop a predictive model. METHODS: In a cohort of patients undergoing TAVR, a prospective evaluation of clinical, anatomical, and physiological parameters was conducted before and after the procedure...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36932281/thirst-neuroendocrine-regulation-in-mammals
#37
REVIEW
Luca Todini, Francesco Fantuz
Animals can sense their changing internal needs and then generate specific physiological and behavioural responses in order to restore homeostasis. Water-saline homeostasis derives from balances of water and sodium intake and output (drinking and diuresis, salt appetite and natriuresis), maintaining an appropriate composition and volume of extracellular fluid. Thirst is the sensation which drives to seek and consume water, regulated in the central nervous system by both neural and chemical signals. Water and electrolyte homeostasis depends on finely tuned physiological mechanisms, mainly susceptible to plasma Na+ concentration and osmotic pressure, but also to blood volume and arterial pressure...
March 18, 2023: Veterinary Research Communications
https://read.qxmd.com/read/36905117/associations-of-atrial-natriuretic-peptide-with-measures-of-insulin-and-adipose-depots
#38
JOURNAL ARTICLE
Catharine A Couch, Lauren A Fowler, Vibhu Parcha, Pankaj Arora, Barbara A Gower
Low concentrations of natriuretic peptides (NPs) have been associated with greater risk for Type 2 diabetes (T2D). African American individuals (AA) have lower NP levels and are disproportionately burdened by T2D. The purpose of this study was to test the hypothesis that higher post-challenge insulin in AA adults is associated with lower plasma N-terminal pro-atrial natriuretic peptide (NT-proANP). A secondary purpose was to explore associations between NT-proANP and adipose depots. Participants were 112 AA and European American (EA) adult men and women...
March 2023: Physiological Reports
https://read.qxmd.com/read/36904273/association-between-intra-and-extra-cellular-water-ratio-imbalance-and-natriuretic-peptides-in-patients-undergoing-hemodialysis
#39
JOURNAL ARTICLE
Yui Nakayama, Yosuke Yamada, Shingo Ishii, Mai Hitaka, Keisuke Yamazaki, Motoyuki Masai, Nobuhiko Joki, Ken Sakai, Yasushi Ohashi
Natriuretic peptides are associated with malnutrition and volume overload. Over-hydration cannot simply be explained by excess extracellular water in patients undergoing hemodialysis. We assessed the relationship between the extracellular and intracellular water (ECW/ICW) ratio, N -terminal pro-B-type natriuretic peptide (NT-proBNP), human atrial natriuretic peptide (hANP), and echocardiographic findings. Body composition was examined by segmental multi-frequency bioelectrical impedance analysis in 368 patients undergoing maintenance dialysis (261 men and 107 women; mean age, 65 ± 12 years)...
March 3, 2023: Nutrients
https://read.qxmd.com/read/36898152/a-glomerulus-chip-with-spherically-twisted-cell-laden-hollow-fibers-as-glomerular-capillary-tufts
#40
JOURNAL ARTICLE
Zhilin Dai, Chengpan Li, Zhengdi Shi, Shibo Li, Tianzhi Luo, Weiping Ding
Glomerulus-on-a-chip, as a promising alternative for drug nephrotoxicity evaluation, is attracting increasing attention. For glomerulus-on-a-chip, the more biomimetic the chip is, the more convincing the application of the chip is. In this study, we proposed a hollow fiber-based biomimetic glomerulus chip that can regulate filtration in response to blood pressure and hormone levels. On the chip developed here, bundles of hollow fibers were spherically twisted and embedded in designed Bowman's capsules to form spherical glomerular capillary tufts, with podocytes and endotheliocytes cultured on the outer and inner surfaces of the hollow fibers, respectively...
March 10, 2023: Biofabrication
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