keyword
https://read.qxmd.com/read/38370014/impact-of-prolonged-exposure-to-occasional-and-regular-waterpipe-smoke-on-cardiac-injury-oxidative-stress-and-mitochondrial-dysfunction-in-male-mice
#1
JOURNAL ARTICLE
Naserddine Hamadi, Suhail Al-Salam, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Abderrahim Nemmar
Regular waterpipe smoking (Reg-WPS) is well recognized for its deleterious effect on the heart. However, there is a paucity of experimental studies on the impact of occasional waterpipe smoking (Occ-WPS), also known as nondaily smoking, versus Reg-WPS on cardiac homeostasis, and the mechanisms underlying these effects. Hence, we aimed, in the present study, to investigate the effect of Occ-WPS (30 min/day, 1 day/week) versus Reg-WPS (30 min/day, 5 days/week) for 6 months on systolic blood pressure (SBP), cardiac injury, oxidative markers, chemokines, proinflammatory cytokines, DNA damage and mitochondrial function compared with air (control) exposed mice...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38345442/transcriptional-cofactor-dyxin-mediates-hypertrophic-response-in-the-heart-during-angiotensin-ii-induced-hypertension
#2
JOURNAL ARTICLE
H Sakkinen, H Luosujarvi, T Karvonen, E Mustonen, A-M Moilanen, J Aro, J Napankangas, H Ruskoaho, J Rysa
Dyxin is a LIM-domain containing transcriptional regulator protein shown to play a role in a hypertrophic response in the heart. Here, the effect of adenoviral dyxin overexpression was studied on cardiac function and gene expression in the normal heart and in angiotensin II (Ang II)-induced hypertension in rats. The adenovirus-mediated intramyocardial gene transfer of dyxin (1.5x109 infectious units/animal) was performed into the left ventricle (LV) of Sprague-Dawley rats with and without the Ang II (33 μg/kg/h) infusion, administered via osmotic minipumps for 1 and 2 weeks...
December 2023: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://read.qxmd.com/read/38314261/reduced-dnmt1-levels-induce-cell-apoptosis-via-upregulation-of-mettl3-in-cardiac-hypertrophy
#3
JOURNAL ARTICLE
Xidong Zhang, Yanhua Nie, Rui Zhang, Jiquan Yu, Jianjun Ge
DNA methylation is also involved in the development and progression of cardiac diseases. Although studies have shown that DNA methylation and RNA m6A methylation play an important role in the development of myocardial hypertrophy, whether DNA methylation and RNA m6A methylation have a coordinated role in the development of myocardial hypertrophy and influence each other is still unknown. Here, we found that DNMT1 expression was downregulated in TAC mice and Ang II-treated NRCMs. Moreover, DNMT1 overexpression inhibited Ang II-induced apoptosis of NRCMs...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38313345/blood-and-imaging-biomarkers-in-the-long-term-follow-up-of-bicuspid-aortic-valve-patients
#4
JOURNAL ARTICLE
Zoë A Keuning, Paul M Hendriks, Anthonie L Duijnhouwer, Frederike Meccanici, Hans-Marc J Siebelink, Allard T van den Hoven, Laurie W Geenen, Jannet A Eindhoven, Vivan J M Baggen, Judith A A E Cuypers, Robert M Kauling, Jolien W Roos-Hesselink, Annemien E van den Bosch
BACKGROUND: Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as valve stenosis and regurgitation. This study aimed to investigate sex differences in blood and imaging biomarkers and to describe the long-term prognostic value of blood and echocardiographic biomarkers. METHODS: Patients were included from 2 prospective observational cohort studies; they underwent venous blood sampling and transthoracic echocardiography including speckle tracking...
January 2024: CJC open
https://read.qxmd.com/read/38312209/rationale-and-design-of-the-pace-hfpef-trial-physiologic-accelerated-pacing-as-a-holistic-treatment-of-heart-failure-with-preserved-ejection-fraction
#5
JOURNAL ARTICLE
Nicole Habel, Margaret Infeld, Jacob Bernknopf, Markus Meyer, Daniel Lustgarten
BACKGROUND: In heart failure with preserved ejection fraction (HFpEF), it has been assumed that pharmacologic heart rate suppression should provide clinical benefits through an increase in diastolic filling time. Contrary to this assumption, heart rate lowering in patients with preserved left ventricular ejection fraction and hypertension or coronary artery disease results in adverse outcomes and suggests that the opposite may be beneficial. Namely, shortening the diastolic filling time with a higher heart rate might normalize the elevated filling pressures that are the sine qua non of HFpEF...
January 2024: Heart rhythm O2
https://read.qxmd.com/read/38275112/protein-kinase-a-is-a-master-regulator-of-physiological-and-pathological-cardiac-hypertrophy
#6
JOURNAL ARTICLE
Yingyu Bai, Xiaoying Zhang, Ying Li, Fei Qi, Chong Liu, Xiaojie Ai, Mingxin Tang, Christopher Szeto, Erhe Gao, Xiang Hua, Mingxing Xie, Xuejun Wang, Ying Tian, Yongjie Chen, Guowei Huang, Junping Zhang, Weidong Xiao, Lili Zhang, Xueyuan Liu, Qing Yang, Steven R Houser, Xiongwen Chen
BACKGROUND: The sympathoadrenergic system and its major effector PKA (protein kinase A) are activated to maintain cardiac output coping with physiological or pathological stressors. If and how PKA plays a role in physiological cardiac hypertrophy (CH) and pathological CH (PaCH) are not clear. METHODS: Transgenic mouse models expressing a PKA inhibition peptide-GFP fusion protein in a cardiac-specific and inducible manner (cPKAi) were used to determine the roles of PKA in physiological CH during postnatal growth or induced by swimming, and in PaCH induced by transaortic constriction (TAC) or augmented Ca2+ influx...
January 26, 2024: Circulation Research
https://read.qxmd.com/read/38246520/corin-deficiency-alleviates-mucosal-lesions-in-a-mouse-model-of-colitis-induced-by-dextran-sulfate-sodium
#7
JOURNAL ARTICLE
Xiabing Gu, Meng Liu, Mengting Wang, Kun Wang, Tiantian Zhou, Qingyu Wu, Ningzheng Dong
AIMS: High dietary salt consumption is a risk factor for inflammatory bowel disease (IBD). Corin is a protease that activates atrial natriuretic peptide (ANP), thereby regulating sodium homeostasis. Corin acts in multiple tissues, including the intestine. In mice, corin deficiency impairs intestinal sodium excretion. This study aims to examine if reduced intestinal sodium excretion alters the pathophysiology of IBD. MAIN METHODS: Wild-type (WT), Corin knockout (KO), and Corin kidney conditional KO (kcKO) mice were tested in a colitis model induced by dextran sulfide sodium (DSS)...
January 19, 2024: Life Sciences
https://read.qxmd.com/read/38224201/complete-loss-of-the-atrial-natriuretic-peptide-converting-enzyme-corin-and-chaf-la-syndrome-implications-to-natriuretic-peptide-physiology-and-left-atrium-health
#8
JOURNAL ARTICLE
Alina Kurolap, Chofit Chai Gadot, David Zahler, Jacob N Ablin, Hagit Baris Feldman
No abstract text is available yet for this article.
January 2024: Clinical and Translational Medicine
https://read.qxmd.com/read/38166254/factors-associated-with-fatigue-in-persons-with-atrial-fibrillation-in-the-atherosclerosis-risk-in-communities-aric-study
#9
JOURNAL ARTICLE
Kathryn A Wood, Aniqa B Alam, Lin Yee Chen, Elsayed Z Soliman, Arshed A Quyyumi, Alvaro Alonso
BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia affecting over 6 million people in the U.S. Fatigue is a frequent symptom of AF, yet no underlying biological mechanisms have been identified in AF-related fatigue as in other chronic conditions such as cancer or HIV fatigue (inflammation, tissue injury). We aimed to identify biomarkers and correlates of AF-fatigue in ARIC participants. METHODS: Participants with AF from ARIC visit 5 (2011-2013) were included in the study...
January 2, 2024: Biological Research for Nursing
https://read.qxmd.com/read/38140281/effects-of-long-term-administration-of-bovine-bone-gelatin-peptides-on-myocardial-hypertrophy-in-spontaneously-hypertensive-rats
#10
JOURNAL ARTICLE
Songmin Cao, Xinyu Wang, Lujuan Xing, Wangang Zhang
The research purpose was to investigate the effects and the underlying molecular mechanisms of bovine bone gelatin peptides (BGP) on myocardial hypertrophy in spontaneously hypertensive rats (SHR). BGP relieved myocardial hypertrophy and fibrosis in SHR rats in a dose-dependent manner by reducing the left ventricular mass index, myocardial cell diameter, myocardial fibrosis area, and levels of myocardial hypertrophy markers (atrial natriuretic and brain natriuretic peptide). Label-free quantitative proteomics analysis showed that long-term administration of BGP changed the left ventricle proteomes of SHR...
December 6, 2023: Nutrients
https://read.qxmd.com/read/38068692/expression-of-cry1ab-2aj-protein-in-genetically-engineered-maize-plants-and-its-transfer-in-the-arthropod-food-web
#11
JOURNAL ARTICLE
Yi Chen, Michael Meissle, Jiabao Xue, Nan Zhang, Shulin Ma, Anping Guo, Biao Liu, Yufa Peng, Xinyuan Song, Yan Yang, Yunhe Li
While transgenic Bacillus thuringiensis ( Bt ) maize provides pest resistance and a reduced application of chemical pesticides, a comprehensive environmental risk assessment is mandatory before its field release. This research determined the concentrations of Bt protein in plant tissue and in arthropods under field conditions in Gongzhuling City, northeastern China, to provide guidance for the selection of indicator species for non-target risk assessment studies. Bt maize expressing Cry1Ab/2Aj and non-transformed near-isoline were grown under identical environmental and agricultural conditions...
December 2, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37975916/circulating-apelin-il22ra2-and-vegf-in-pre-capillary-pulmonary-hypertension
#12
JOURNAL ARTICLE
Györgyi Csósza, Gergő Szűcs, Zsolt Rozgonyi, Balázs Csoma, György Losonczy, Veronika Müller, Kristóf Karlócai, Zsófia Lázár
Cytokines can modulate vascular remodelling and the adaptation of the right ventricle in pre-capillary pulmonary hypertension (PH). However, detailed data on the circulating levels of cytokines in patients are limited. We measured blood cytokine concentration in 39 treatment-naïve patients (pulmonary arterial hypertension: N = 16, chronic thromboembolic PH: N = 15, PH due to lung disease: N = 8) and 12 control subjects using enzyme-linked immunoassays. Apelin concentration >1,261 ng/mL identified patients with PH (66% sensitivity and 82% specificity), and in patients it was related to systolic pulmonary arterial pressure (PAP) (r = 0...
November 17, 2023: Physiology International
https://read.qxmd.com/read/37960105/evaluating-nitrogen-management-practices-for-greenhouse-gas-emission-reduction-in-a-maize-farmland-in-the-north-china-plain-adapting-to-climate-change
#13
JOURNAL ARTICLE
Huayun He, Qi Hu, Feifei Pan, Xuebiao Pan
Quantification of the trade-offs among greenhouse gas (GHG) emissions, yield, and farmers' incomes is essential for proposing economic and environmental nitrogen (N) management strategies for optimizing agricultural production. A four-year (2017-2020) field experiment (including four treatments: basic N fertilizer treatment (BF), suitable utilization of fertilization (SU), emission reduction treatment (ER), and high fertilization (HF)) was conducted on maize ( Zea mays L.) in the North China Plain. The Life Cycle Assessment (LCA) method was used in this study to quantify the GHG emissions and farmers' incomes during the whole maize production process...
November 2, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37942826/how-should-we-assess-the-cardiovascular-system-in-patients-presenting-with-bothersome-nocturia-ici-rs-2023
#14
REVIEW
Irina Verbakel, Jason Lazar, Sanjay Sinha, Hashim Hashim, Jeffrey P Weiss, Paul Abrams, Karel Everaert
AIMS: The link between nocturia and cardiovascular disease (CVD) is frequently discussed in literature, yet the precise nature of this relationship remains poorly characterized. The existing literature was reviewed in order to address issues concerning the origin, diagnosis, management, and implications of the co-occurrence of CVD and nocturia. METHODS: This review summarizes literature and recommendations regarding the link between CVD and nocturia discussed during a think-tank meeting held at the 2023 International Consultation on Incontinence-Research Society...
November 9, 2023: Neurourology and Urodynamics
https://read.qxmd.com/read/37917630/exercise-performance-is-not-improved-in-mice-with-skeletal-muscle-deletion-of-natriuretic-peptide-clearance-receptor
#15
JOURNAL ARTICLE
Brigitte Jia, Alexander Hasse, Fubiao Shi, Sheila Collins
Natriuretic peptides (NP), including atrial, brain, and C-type natriuretic peptides (ANP, BNP, and CNP), play essential roles in regulating blood pressure, cardiovascular homeostasis, and systemic metabolism. One of the major metabolic effects of NP is manifested by their capacity to stimulate lipolysis and the thermogenesis gene program in adipocytes, however, in skeletal muscle their effects on metabolism and muscle function are not as well understood. There are three NP receptors (NPR): NPRA, NPRB, and NPRC, and all three NPR genes are expressed in skeletal muscle and C2C12 myocytes...
2023: PloS One
https://read.qxmd.com/read/37896106/response-mechanisms-of-woody-plants-to-high-temperature-stress
#16
REVIEW
Chao Zhou, Shengjiang Wu, Chaochan Li, Wenxuan Quan, Anping Wang
High-temperature stress is the main environmental stress that restricts the growth and development of woody plants, and the growth and development of woody plants are affected by high-temperature stress. The influence of high temperature on woody plants varies with the degree and duration of the high temperature and the species of woody plants. Woody plants have the mechanism of adapting to high temperature, and the mechanism for activating tolerance in woody plants mainly counteracts the biochemical and physiological changes induced by stress by regulating osmotic adjustment substances, antioxidant enzyme activities and transcription control factors...
October 22, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37808684/prenatal-arsenite-exposure-alters-maternal-cardiac-remodeling-during-late-pregnancy
#17
Nicole Taube, Raihan Kabir, Obialunanma V Ebenebe, Haley Garbus, Sarah-Marie Alam El Din, Emily Illingworth, Michael Fitch, Nadan Wang, Mark J Kohr
Exposure to inorganic arsenic through drinking water is widespread and has been linked to many chronic diseases, including cardiovascular disease. Arsenic exposure has been shown to alter hypertrophic signaling in the adult heart, as well as in-utero offspring development. However, the effect of arsenic on maternal cardiac remodeling during pregnancy has not been studied. As such, there is a need to understand how environmental exposure contributes to adverse pregnancy-related cardiovascular events. This study seeks to understand the impact of trivalent inorganic arsenic exposure during gestation on maternal cardiac remodeling in late pregnancy, as well as offspring outcomes...
September 29, 2023: bioRxiv
https://read.qxmd.com/read/37747059/thyroid-hormone-induces-restrictive-cardiomyopathy-in-%C3%AE-1-adrenoceptor-knockout-mice
#18
REVIEW
Anderson L B da Silveira, Fernando A C Seara, Danilo Lustrino, André S Mecawi, José Antunes-Rodrigues, Ísis C Kettelhut, Patrícia Chakur-Brum, Luis C Reis, Emerson L Olivares
The purpose of this study was to characterize the role of β1 -AR signaling and its cross-talk between cardiac renin-angiotensin system and thyroid-hormone-induced cardiac hypertrophy. T3 was administered at 0.5 mg·kg-1 ·day-1 for 10 days in β1-KOT3 and WTT3 groups, while control groups received vehicle alone. Echocardiography and myocardial histology was performed; cardiac and serum ANGI/ANGII and ANP and cardiac levels of p-PKA, p-ERK1/2, p-p38-MAPK, p-AKT, p-4EBP1, and ACE were measured...
September 25, 2023: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/37672250/vasoactive-mediators-of-hypertension-in-obesity
#19
JOURNAL ARTICLE
Husam Ghanim, Tina K Thethi, Sanaa Abuaysheh, Vivian Fonseca, Paresh Dandona
OBJECTIVE: Obesity is associated with hypertension. However, mechanisms involved are not fully understood. Therefore, we investigated the relationship between obesity and vasoactive mediators. METHODS: In this cross-sectional study, blood pressure (BP) and vasoactive mediators of hypertension are compared among 135 adults in the non-obese, obese, and morbidly obese BMI ranges (BMI ≤27, 30-40, and >40 kg/m2 , respectively). Angiotensinogen, angiotensin II, renin, aldosterone, Endothelin-1 (ET-1), neprilysin, ANP, BNP, cGMP, cAMP levels were measured and their relationship to BP, BMI, race, and gender were investigated...
September 6, 2023: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/37603904/dietary-fiber-intake-is-positively-associated-with-health-related-quality-of-life-in-patients-with-hypertension-the-mediating-role-of-anxiety-in-mental-component-summary
#20
JOURNAL ARTICLE
Anping Lu, Jingjing Li, Yuanyuan Liu, Xiaojiao Du, Yun Wang, Xiaohua Wang
Few studies have focused on the exploration of the relationship between dietary fiber intake (DFI) and health-related quality of life (HRQoL) and its mediators in hypertensive patients. This study is a cross-sectional survey and the data were obtained from hypertensive patients from Suzhou, China. The DFI, office systolic blood pressure and diastolic blood pressure, anxiety and depression, and HRQoL were investigated. We hypothesized that blood pressure, anxiety, and depression mediated the association between DFI and HRQoL, and used Pearson correlations, linear regression, and bootstrap tests to validate this relationship...
July 29, 2023: Nutrition Research
keyword
keyword
62898
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.