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https://www.readbyqxmd.com/read/27754186/sp-04-1-the-role-of-natriuretic-peptides-in-the-pathogenesis-of-cardiovascular-diseases
#1
Zhanna Kobalava
The burden of cardiovascular diseases (CVD) in general and heart failure (HF) in particular continues to increase worldwide. CVD are major contributors to death and morbidity and recognized as important drivers of healthcare expenditure. Chronic overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in human hypertension and HF pathophysiology. RAAS is fundamental in the overall regulation of cardiovascular homeostasis through the actions of hormones, which regulate vascular tone, and specifically blood pressure through vasoconstriction and renal sodium and water retention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27713761/genome-wide-identification-phylogeny-and-expression-analyses-of-the-14-3-3-family-reveal-their-involvement-in-the-development-ripening-and-abiotic-stress-response-in-banana
#2
Meiying Li, Licheng Ren, Biyu Xu, Xiaoliang Yang, Qiyu Xia, Pingping He, Susheng Xiao, Anping Guo, Wei Hu, Zhiqiang Jin
Plant 14-3-3 proteins act as critical components of various cellular signaling processes and play an important role in regulating multiple physiological processes. However, less information is known about the 14-3-3 gene family in banana. In this study, 25 14-3-3 genes were identified from the banana genome. Based on the evolutionary analysis, banana 14-3-3 proteins were clustered into ε and non-ε groups. Conserved motif analysis showed that all identified banana 14-3-3 genes had the typical 14-3-3 motif...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27643143/sp-04-1-the-role-of-natriuretic-peptides-in-the-pathogenesis-of-cardiovascular-diseases
#3
Zhanna Kobalava
The burden of cardiovascular diseases (CVD) in general and heart failure (HF) in particular continues to increase worldwide. CVD are major contributors to death and morbidity and recognized as important drivers of healthcare expenditure. Chronic overactivity of the renin-angiotensin-aldosterone system (RAAS) plays a key role in human hypertension and HF pathophysiology. RAAS is fundamental in the overall regulation of cardiovascular homeostasis through the actions of hormones, which regulate vascular tone, and specifically blood pressure through vasoconstriction and renal sodium and water retention...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27619808/natural-history-after-acute-necrotizing-pancreatitis-a-large-us-tertiary-care-experience
#4
Chandraprakash Umapathy, Amit Raina, Shreyas Saligram, Gong Tang, Georgios I Papachristou, Mordechai Rabinovitz, Jennifer Chennat, Herbert Zeh, Amer H Zureikat, Melissa E Hogg, Kenneth K Lee, Melissa I Saul, David C Whitcomb, Adam Slivka, Dhiraj Yadav
BACKGROUND: Most studies of acute necrotizing pancreatitis (ANP) focus on short-term outcomes. We evaluated long-term survival and outcomes following ANP. METHODS: Patients treated for ANP at the University of Pittsburgh Medical Center from 2001 to 2008 were studied. Data on presentation and course during initial hospitalization and follow-up (median 34 months) was extracted. RESULTS: Mean age of patients (n = 167) was 53 ± 16 years; 70 % were male, 94 % white, 71 % transfers, 52 % biliary etiology, and 78 % had first-attack of acute pancreatitis...
September 12, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27605464/-epicatechin-induces-physiological-cardiac-growth-by-activation-of-the-pi3k-akt-pathway-in-mice
#5
Sergio De Los Santos, Viridiana García-Pérez, Sauri Hernández-Reséndiz, Carlos Palma-Flores, Carlos J González-Gutiérrez, Cecilia Zazueta, Patricia Canto, Ramón M Coral-Vázquez
SCOPE: The flavanol (-)-epicatechin (Epi) has cardioprotective effects and improves physical capacity in normal mice. In addition, Epi increases nitric oxide (NO) production by activation of both PI3K/Akt or Ca(2+) /CaMI/CaMKII (where Akt is protein kinase B; PI3K is phosphoinositide 3-kinase; CaMI is calmodulin; CaMKII is Ca(2+) /calmodulin-dependent protein kinase II) signaling pathways, which have been associated with physiological and pathological cardiac hypertrophy, respectively...
September 8, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27518466/hydrogen-rich-saline-attenuates-acute-hepatic-injury-in-acute-necrotizing-pancreatitis-by-inhibiting-inflammation-and-apoptosis-involving-jnk-and-p38-mitogen-activated-protein-kinase-dependent-reactive-oxygen-species
#6
Qiao Shi, Chen Chen, Wen-Hong Deng, Peng Wang, Teng Zuo, Liang Zhao, Jia Yu, Kai-Liang Zhao, Fang-Chao Mei, Chen Li, Gui-Rong Wang, Wei-Xing Wang
OBJECTIVES: The objective of this study was to study the role of hydrogen-rich saline (HRS) on acute hepatic injury (AHI) in acute necrotizing pancreatitis (ANP). METHODS: Rats were used for this study and an ANP model was induced by injecting 5% sodium taurocholate into the biliary-pancreatic duct. Experiments were performed in 3 groups: sham, ANP, and ANP + HRS (HRS). Animals were killed at 3, 12, and 24 hours after operation, and then blood and tissue samples were harvested...
November 2016: Pancreas
https://www.readbyqxmd.com/read/27496822/serum-proatrial-natriuretic-peptide-does-not-increase-with-higher-systolic-blood-pressure-in-obese-men
#7
Camilla L Asferg, Ulrik B Andersen, Allan Linneberg, Paula L Hedley, Michael Christiansen, Jens P Goetze, Jørgen L Jeppesen
OBJECTIVE: Obese persons have low circulating natriuretic peptide (NP) concentrations. It has been proposed that this 'natriuretic handicap' could play a role in obesity-related hypertension. The normal physiological response of the NP system to an increase in blood pressure (BP) is an increase in NP secretion with concomitant higher circulating NP concentrations. In this study, we investigated whether higher BP would also be related to higher circulating NP concentrations in obese men; furthermore, we verified that BP had affected the hearts of our study participants, by determining left ventricular mass (LVM)...
August 5, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27436224/biomarkers-in-persistent-af-and-heart-failure-impact-of-catheter-ablation-compared-with-rate-control
#8
David G Jones, Shouvik K Haldar, Jacqueline Donovan, Theresa A McDonagh, Rakesh Sharma, Wajid Hussain, Vias Markides, Tom Wong
BACKGROUND: To investigate the effects of catheter ablation and rate control strategies on cardiac and inflammatory biomarkers in patients with heart failure and persistent atrial fibrillation (AF). METHODS: Patients were recruited from the ARC-HF trial (catheter Ablation vs Rate Control for management of persistent AF in Heart Failure, NCT00878384), which compared ablation with rate control for persistent AF in heart failure. B-type natriuretic peptide (BNP), midregional proatrial natriuretic peptide (MR-proANP), apelin, and interleukin-6 (IL-6) were assayed at baseline, 3 months, 6 months, and 12 months...
September 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27419272/biological-markers-for-anxiety-disorders-ocd-and-ptsd-a-consensus-statement-part-ii-neurochemistry-neurophysiology-and-neurocognition
#9
Borwin Bandelow, David Baldwin, Marianna Abelli, Blanca Bolea-Alamanac, Michel Bourin, Samuel R Chamberlain, Eduardo Cinosi, Simon Davies, Katharina Domschke, Naomi Fineberg, Edna Grünblatt, Marek Jarema, Yong-Ku Kim, Eduard Maron, Vasileios Masdrakis, Olya Mikova, David Nutt, Stefano Pallanti, Stefano Pini, Andreas Ströhle, Florence Thibaut, Matilde M Vaghi, Eunsoo Won, Dirk Wedekind, Adam Wichniak, Jade Woolley, Peter Zwanzger, Peter Riederer
OBJECTIVE: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD). METHODS: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network...
July 15, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/27417117/in-exog-depleted-cardiomyocytes-cell-death-is-marked-by-a-decreased-mitochondrial-reserve-capacity-of-the-electron-transport-chain
#10
Wardit Tigchelaar, Anne Margreet De Jong, Wiek H van Gilst, Rudolf A De Boer, Herman H W Silljé
Depletion of mitochondrial endo/exonuclease G-like (EXOG) in cultured neonatal cardiomyocytes stimulates mitochondrial oxygen consumption rate (OCR) and induces hypertrophy via reactive oxygen species (ROS). Here, we show that neurohormonal stress triggers cell death in endo/exonuclease G-like-depleted cells, and this is marked by a decrease in mitochondrial reserve capacity. Neurohormonal stimulation with phenylephrine (PE) did not have an additive effect on the hypertrophic response induced by endo/exonuclease G-like depletion...
July 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27395008/towards-elucidation-of-the-toxic-mechanism-of-copper-on-the-model-green-alga-chlamydomonas-reinhardtii
#11
Yongguang Jiang, Yanli Zhu, Zhangli Hu, Anping Lei, Jiangxin Wang
Toxic effects of copper on aquatic organisms in polluted water bodies have garnered particular attention in recent years. Microalgae play an important role in aquatic ecosystems, and they are sensitive to heavy metal pollution. Thus, it is important to clarify the mechanism of copper toxicity first for ecotoxicology studies. In this study, the physiological, biochemical and gene expression characteristics of a model green microalga, Chlamydomonas reinhardtii, with 0, 50, 150 and 250 μM copper treatments were investigated...
September 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27343265/localization-of-corin-and-atrial-natriuretic-peptide-expression-in-human-renal-segments
#12
Liang Dong, Hao Wang, Ningzheng Dong, Ce Zhang, Boxin Xue, Qingyu Wu
Atrial natriuretic peptide (ANP)-mediated natriuretic response is a well-established cardiac endocrine function. Corin is a transmembrane protease that activates ANP in the heart. Corin expression has been detected in non-cardiac tissues including the kidney. Here we examined corin, pro-ANP/ANP and natriuretic peptide receptor-A (NPR-A) expression in human renal segments. By immunostaining and in situ hybridization, we found similar corin, pro-ANP/ANP and NPR-A protein and mRNA expression in human renal segments...
September 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27303428/comparative-physiological-and-transcriptomic-analyses-reveal-the-actions-of-melatonin-in-the-delay-of-postharvest-physiological-deterioration-of-cassava
#13
Wei Hu, Hua Kong, Yunling Guo, Yuliang Zhang, Zehong Ding, Weiwei Tie, Yan Yan, Qixing Huang, Ming Peng, Haitao Shi, Anping Guo
Melatonin plays important roles in various aspects of biological processes. However, it is less known on the effects and mechanism of melatonin on the postharvest physiological deterioration (PPD) process of cassava, which largely restricts the potential of cassava as a food and industrial crop. In this study, we found that exogenous application of melatonin significantly delayed PPD of cassava tuberous roots by reducing H2O2 content and improving activities of catalase and peroxidase. Moreover, 3425 differentially expressed genes by melatonin during the PPD process were identified by transcriptomic analysis...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27302851/augmented-renal-clearance-arc-in-traumatic-brain-injury-tbi-a-single-center-observational-study-of-atrial-natriuretic-peptide-cardiac-output-and-creatinine-clearance
#14
Andrew Udy, Paul Jarrett, Melissa Lassig-Smith, Janine Stuart, Therese Starr, Rachel Dunlop, Renae Deans, Jason A Roberts, Siva Senthuran, Rob Boots, Kavita Bisht, Andrew C Bulmer, Jeffrey Lipman
Augmented renal clearance (ARC) is being increasingly described in neurocritical care practice. The mechanisms driving this phenomenon are largely unknown. The aim of this project was therefore to explore changes in renal function, cardiac output (CO), and atrial natriuretic peptide (ANP) concentrations in patients with isolated traumatic brain injury (TBI). This prospective observational cohort study was conducted in a tertiary level university affiliated ICU. Patients with normal plasma creatinine concentrations (< 120 μmol/L) at admission and no history of chronic kidney disease, admitted with isolated TBI, were eligible for enrolment...
June 14, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27241248/are-endogenous-cardenolides-controlled-by-atrial-natriuretic-peptide
#15
Kanwarjeet S Brar, Yonglin Gao, Rif S El-Mallakh
Endogenous cardenolides are digoxin-like substances and ouabain-like substances that have been implicated in the pathogenesis of hypertension and mood disorders in clinical and pre-clinical studies. Regulatory signals for endogenous cardenolides are still unknown. These endogenous compounds are believed to be produced by the adrenal gland in the periphery and the hypothalamus in the central nervous system, and constitute part of an hormonal axis that may regulate the catalytic activity of the α subunit of Na(+)/K(+)-ATPase...
July 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27208702/effects-of-endothelin-family-on-anp-secretion
#16
Kuichang Yuan, Byung Mun Park, Young Tae Choi, Jong Hun Kim, Kyung Woo Cho, Suhn Hee Kim
The endothelins (ET) peptide family consists of ET-1, ET-2, ET-3, and sarafotoxin (s6C, a snake venom) and their actions appears to be different among isoforms. The aim of this study was to compare the secretagogue effect of ET-1 on atrial natriuretic peptide (ANP) secretion with ET-3 and evaluate its physiological meaning. Isolated nonbeating atria from male Sprague-Dawley rats were used to evaluate stretch-activated ANP secretion in response to ET-1, ET-2, ET-3, and s6C. Changes in mean blood pressure (MAP) were measured during acute injection of ET-1 and ET-3 with and without natriuretic peptide receptor-A antagonist (A71915) in anesthetized rats...
August 2016: Peptides
https://www.readbyqxmd.com/read/27102652/serum-natriuretic-peptides-as-differential-biomarkers-allowing-for-the-distinction-between-physiologic-and-pathologic-left-ventricular-hypertrophy
#17
Michael E Dunn, Thomas G Manfredi, Kevin Agostinucci, Steven K Engle, Josh Powe, Nicholas M P King, Luis A Rodriguez, Kathryn E Gropp, Matthew Gallacher, Frederick J Vetter, Vijay More, Prajakta Shimpi, David Serra, Heidi M Colton
Given the proven utility of natriuretic peptides as serum biomarkers of cardiovascular maladaptation and dysfunction in humans and the high cross-species sequence conservation of atrial natriuretic peptides, natriuretic peptides have the potential to serve as translational biomarkers for the identification of cardiotoxic compounds during multiple phases of drug development. This work evaluated and compared the response of N-terminal proatrial natriuretic peptide (NT-proANP) and N-terminal probrain natriuretic peptide (NT-proBNP) in rats during exercise-induced and drug-induced increases in cardiac mass after chronic swimming or daily oral dosing with a peroxisome proliferator-activated receptor γ agonist...
April 21, 2016: Toxicologic Pathology
https://www.readbyqxmd.com/read/27074051/endoplasmic-reticulum-stress-is-involved-in-dfmo-attenuating-isoproterenol-induced-cardiac-hypertrophy-in-rats
#18
Yan Lin, Xiaojie Zhang, Wei Xiao, Bo Li, Jun Wang, Li Jin, Jie Lian, Li Zhou, Jicheng Liu
BACKGROUND/AIMS: Studies performed in experimental animals have shown that polyamines contribute to several physiological and pathological processes, including cardiac hypertrophy. This involves an increase in ornithine decarboxylase (ODC) activity and intracellular polyamines associated with regulation of gene expression. Difluoromethylornithine (DFMO), an irreversible inhibitor of ODC, has attracted considerable interest for its antiproliferative role, which it exerts through inhibition of the polyamine pathway and cell turnover...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26622395/prognostic-value-of-natriuretic-peptides-in-severe-trauma-patients-with-multiple-organ-dysfunction-syndrome
#19
Nan Li, Zhi Song, Jing Wang, Yue Teng, Yan Cui, Hongxu Jin, Yan Gao
The aim of the present study was to evaluate the prognostic values of the N-terminal peptide of pro-atrial natriuretic peptide (NT-proANP) and the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) in severe trauma patients developing multiple organ dysfunction syndrome (MODS). Out of the 126 severe trauma patients that were admitted to the Emergency Intensive Care Unit of the General Hospital of Shenyang Military Region between January 2009 and December 2011, 26 patients with multiple injuries and an injury severity score (ISS) of >16 points were included in the study...
August 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26549290/addition-of-a-nitric-oxide-donor-to-an-angiotensin-ii-type-1-receptor-blocker-may-cancel-its-blood-pressure-lowering-effects
#20
Eiji Yahiro, Shin-Ichiro Miura, Yasunori Suematsu, Yoshino Matsuo, Tadaaki Arimura, Takashi Kuwano, Satoshi Imaizumi, Atsushi Iwata, Yoshinari Uehara, Keijiro Saku
While physiological levels of nitric oxide (NO) protect the endothelium and have vasodilatory effects, excessive NO has adverse effects on the cardiovascular system. Recently, new NO-releasing pharmacodynamic hybrids of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) have been developed.We analyzed whether olmesartan with NO-donor side chains (Olm-NO) was superior to olmesartan (Olm) for the control of blood pressure (BP). Although there was no significant difference in binding affinity to AT1 wild-type (WT) receptor between Olm and Olm-NO in a cell-based binding assay, the suppressive effect of Olm-NO on Ang II-induced inositol phosphate (IP) production was significantly weaker than that of Olm in AT1 WT receptor-expressing cells...
2015: International Heart Journal
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