Husam Ghanim, Tina K Thethi, Sanaa Abuaysheh, Vivian Fonseca, Paresh Dandona
OBJECTIVE: Obesity is associated with hypertension. However, mechanisms involved are not fully understood. Therefore, we investigated the relationship between obesity and vasoactive mediators. METHODS: In this cross-sectional study, blood pressure (BP) and vasoactive mediators of hypertension are compared among 135 adults in the non-obese, obese, and morbidly obese BMI ranges (BMI ≤27, 30-40, and >40 kg/m2 , respectively). Angiotensinogen, angiotensin II, renin, aldosterone, Endothelin-1 (ET-1), neprilysin, ANP, BNP, cGMP, cAMP levels were measured and their relationship to BP, BMI, race, and gender were investigated...
September 6, 2023: American Journal of Physiology. Endocrinology and Metabolism