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https://www.readbyqxmd.com/read/28421498/chapter-14-establishing-an-oocyte-cryobank-network
#1
James Graham, Josh Lim, Michael Tucker
Improvements in oocyte cryopreservation has prompted wider acceptance of this technology leading to its use for several reasons. Notably, in addition to elective and medically driven reasons for oocyte cryostorage for fertility preservation, donor oocyte cryobanking is beginning to gain traction, potentially replacing fresh oocyte donation in assisted reproduction. Donor "egg banking," while not totally analogous to donor sperm banking, does provide strong benefits in terms of scheduling flexibility and improved clinical efficiencies, while providing a wider immediate inventory choice...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28405672/glucagon-like-peptide-1-related-peptides-increase-nitric-oxide-effects-to-reduce-platelet-activation
#2
Cristina Barale, Simona Buracco, Franco Cavalot, Chiara Frascaroli, Angelo Guerrasio, Isabella Russo
Glucagon-like peptide 1 (GLP-1) is object of intensive investigation for not only its metabolic effects but also the protective vascular actions. Since platelets exert a primary role in the pathogenesis of atherosclerosis, inflammation and vascular complications, we investigated whether GLP-1 directly influences platelet reactivity. For this purpose, in platelets from 72 healthy volunteers we evaluated GLP-1 receptor (GLP-1R) expression and the effects of a 15-minute incubation with the native form GLP-1(7-36), the N-terminally truncated form GLP-1(9-36) and the GLP-1 analogue Liraglutide (100 nmol/l) on: i) aggregation induced by collagen or arachidonic acid (AA); ii) platelet function under shear stress; iii) cGMP and cAMP synthesis and cGMP-dependent protein kinase (PKG)-induced Vasodilator-Stimulated-Phosphoprotein (VASP) phosphorylation; iv) activation of the signalling molecules Phosphatidylinositol 3-Kinase (PI3-K)/Akt and Mitogen Activated Protein Kinase (MAPK)/ERK-1/2; and v) oxidative stress...
April 13, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28402390/hybridization-drives-evolution-of-apomicts-in-rubus-subgenus-rubus-evidence-from-microsatellite-markers
#3
Petra Šarhanová, Timothy F Sharbel, Michal Sochor, Radim J Vašut, Martin Dancák, Bohumil Trávnícek
Background and Aims: Rubus subgenus Rubus is a group of mostly apomictic and polyploid species with a complicated taxonomy and history of ongoing hybridization. The only polyploid series with prevailing sexuality is the series Glandulosi , although the apomictic series Discolores and Radula also retain a high degree of sexuality, which is influenced by environmental conditions and/or pollen donors. The aim of this study is to detect sources of genetic variability, determine the origin of apomictic taxa and validate microsatellite markers by cloning and sequencing...
April 11, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28400196/association-of-rnaset2-gene-polymorphisms-with-decreased-expression-and-clinical-characteristics-of-severity-in-crohn-s-disease
#4
Rivkah Gonsky, Phillip Fleshner, Richard L Deem, Eva Biener-Ramanujan, Dalin Li, Alka A Potdar, Janine Bilsborough, Shaohong Yang, Dermot P B McGovern, Stephan R Targan
BACKGROUND & AIMS: Variants in the tumor necrosis factor superfamily member 15 gene (TNFSF15, also called TL1A) have been associated with risk for inflammatory bowel diseases (IBD). TL1A affects expression of multiple cytokines to promote mucosal inflammation. Little is known about the TL1A-response pathways that regulate cytokine expression. We investigated T-cell gene expression patterns to determine the mechanisms by which TL1A regulates cytokine production, and whether these associate with outcomes of patients with Crohn's disease (CD)...
April 8, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28397153/meldna-score-is-associated-with-psychopathology-and-reduced-quality-of-life-in-cirrhotic-patients-with-a-liver-transplant-perspective
#5
Gabriele Cavaggioni, Edoardo Poli, Flaminia Ferri, Lucia Parlati, Valentina Monaco, Claudia Melcore, Barbara Lattanzi, Manuela Merli, Gianluca Mennini, Fabio Melandro, Massimo Rossi, Stefano Ginanni Corradini
Psychopathological symptoms and reduced health related quality of life (HRQoL) are frequent in cirrhotics, but no data on their association with cirrhosis prognosis assessed by the MELDNa score are available. Prospective data on the long-term effect of deceased donor liver transplantation (LT) on psychopathological symptoms are needed. Before entering the LT waiting list, 44 consecutive LT cirrhotic candidates without a major psychiatric disorder underwent a psychopathological assessment, including Symptom Checklist-90-revised (SCL-90-R) and Defense Style Questionnaire (DSQ)...
April 11, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28396487/culture-time-of-vitrified-warmed-zygotes-before-microinjection-affects-the-production-efficiency-of-crispr-cas9-mediated-knock-in-mice
#6
Yoshiko Nakagawa, Tetsushi Sakuma, Norihisa Nishimichi, Yasuyuki Yokosaki, Toru Takeo, Naomi Nakagata, Takashi Yamamoto
Robust reproductive engineering techniques are required for the efficient and rapid production of genetically modified mice. We have reported the efficient production of genome-edited mice using reproductive engineering techniques, such as ultra-superovulation, in vitro fertilization (IVF) and vitrification/warming of zygotes. We usually use vitrified/warmed fertilized oocytes created by IVF for microinjection because of work efficiency and flexible scheduling. Here, we investigated whether the culture time of zygotes before microinjection influences the efficiency of producing knock-in mice...
April 10, 2017: Biology Open
https://www.readbyqxmd.com/read/28394024/a-brief-motivational-interview-promotes-internal-motivation-to-donate-blood-among-young-adults-with-and-without-a-prior-donation-history
#7
Irina E Livitz, Kristen R Fox, Lina K Himawan, Christopher R France
BACKGROUND: Recruitment and retention of first-time and repeat donors is essential to maintain a stable blood supply. Recent evidence has shown that promoting internal motivation may be an effective strategy to enhance donation behavior. We tested the efficacy of an in-person motivational interview at increasing internal motivation and intention to donate. STUDY DESIGN AND METHODS: A sample of 219 donors and nondonors (69.4% female; mean ± SD age, 19.2 ± 1...
April 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28392793/rapid-introgression-of-the-fusarium-wilt-resistance-gene-into-an-elite-cabbage-line-through-the-combined-application-of-a-microspore-culture-genome-background-analysis-and-disease-resistance-specific-marker-assisted-foreground-selection
#8
Xing Liu, Fengqing Han, Congcong Kong, Zhiyuan Fang, Limei Yang, Yangyong Zhang, Mu Zhuang, Yumei Liu, Zhansheng Li, Honghao Lv
Cabbage is an economically important vegetable worldwide. Cabbage Fusarium Wilt (CFW) is a destructive disease that results in considerable yield and quality losses in cole crops. The use of CFW-resistant varieties is the most effective strategy to mitigate the effects of CFW. 01-20 is an elite cabbage line with desirable traits and a high combining ability, but it is highly susceptible to CFW. To rapidly transfer a CFW resistance gene into 01-20 plants, we used microspore cultures to develop 230 doubled haploid (DH) lines from a cross between 01-20 (highly susceptible) and 96-100 (highly resistant)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28389255/relative-telomere-length-prior-to-hematopoietic-cell-transplantation-hct-and-outcome-after-unrelated-donor-hct-for-acute-leukemia
#9
Youjin Wang, Tao Wang, Casey Dagnall, Michael Haagenson, Stephen R Spellman, Belynda Hicks, Kristine Jones, Stephanie J Lee, Sharon A Savage, Shahinaz M Gadalla
Telomeres are tandem nucleotide repeats and a protein complex located at the end of the chromosomes maintaining genomic stability. Their potential as a predictive biomarker for outcomes after allogeneic hematopoietic cell transplant (HCT) in hematologic malignancies is still unclear. From the Center for International Blood and Marrow Transplant Research (CIBMTR), we randomly selected 536 acute leukemia (AL) patients from those who underwent myeloablative 8/8 HLA-matched unrelated donor HCT between 2005 and 2012, and who had an available pre-HCT blood sample in the repository...
April 4, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28381797/development-of-cassette-pampa-for-permeability-screening
#10
Mun Hwan Oh, Hye Jin Lee, Sang Hyun Jo, Bernie Byunghoon Park, Sae-Bom Park, Eun-Yeong Kim, Yuanyuan Zhou, Young Ho Jeon, Kiho Lee
The parallel artificial membrane permeability assay (PAMPA) is widely used in early-stage drug discovery to discriminate compounds by intestinal permeability. The purpose of the current study was to establish a cassette (n-in-1) PAMPA to enable permeability screening of lipophilic compounds. A double-sink PAMPA consisting of a pH gradient (i.e., pH 6.5 and 7.4 for the donor and receiver compartments, respectively) and a lipophilic sink (i.e., a surfactant in the receiver solution) was utilized with cassette incubation of 10 reference compounds...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28378716/unusual-4-arsonoanilinium-cationic-species-in-the-hydrochloride-salt-of-4-aminophenyl-arsonic-acid-and-formed-in-the-reaction-of-the-acid-with-copper-ii-sulfate-copper-ii-chloride-and-cadmium-chloride
#11
Graham Smith, Urs D Wermuth
Structures having the unusual protonated 4-arsonoanilinium species, namely in the hydrochloride salt, C6H9AsNO3(+)·Cl(-), (I), and the complex salts formed from the reaction of (4-aminophenyl)arsonic acid (p-arsanilic acid) with copper(II) sulfate, i.e. hexaaquacopper(II) bis(4-arsonoanilinium) disulfate dihydrate, (C6H9AsNO3)2[Cu(H2O)6](SO4)2·2H2O, (II), with copper(II) chloride, i.e. poly[bis(4-arsonoanilinium) [tetra-μ-chlorido-cuprate(II)]], {(C6H9AsNO3)2[CuCl4]}n, (III), and with cadmium chloride, i...
April 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/28378521/defining-the-immunogenicity-and-antigenicity-of-hla-epitopes-is-crucial-for-optimal-epitope-matching-in-clinical-renal-transplantation
#12
REVIEW
C S M Kramer, D L Roelen, S Heidt, F H J Claas
Transplantation of an human leukocyte antigen (HLA) mismatched graft can lead to the development of donor-specific antibodies (DSA), which can result in antibody mediated rejection and graft loss as well as complicate repeat transplantation. These DSA are induced by foreign epitopes present on the mismatched HLA antigens of the donor. However, not all epitopes appear to be equally effective in their ability to induce DSA. Understanding the characteristics of HLA epitopes is crucial for optimal epitope matching in clinical transplantation...
April 5, 2017: HLA
https://www.readbyqxmd.com/read/28377748/evidence-for-contemporary-switching-of-the-o-antigen-gene-cluster-between-shiga-toxin-producing-escherichia-coli-strains-colonizing-cattle
#13
Lutz Geue, Christian Menge, Inga Eichhorn, Torsten Semmler, Lothar H Wieler, Derek Pickard, Christian Berens, Stefanie A Barth
Shiga toxin-producing Escherichia coli (STEC) comprise a group of zoonotic enteric pathogens with ruminants, especially cattle, as the main reservoir. O-antigens are instrumental for host colonization and bacterial niche adaptation. They are highly immunogenic and, therefore, targeted by the adaptive immune system. The O-antigen is one of the most diverse bacterial cell constituents and variation not only exists between different bacterial species, but also between individual isolates/strains within a single species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28375576/phylogenetic-evidence-for-underreporting-of-male-to-male-sex-among-human-immunodeficiency-virus-infected-donors-in-the-netherlands-and-flanders
#14
Thijs J van de Laar, Daniela Bezemer, Kristel van Laethem, Giovani Vandewalle, Annie de Smet, Eric van Wijngaerden, Eric C Claas, Ard I van Sighem, Anne-Mieke Vandamme, Veerle Compernolle, Hans L Zaaijer
BACKGROUND: Separate transmission networks for human immunodeficiency virus (HIV) coexist. Molecular typing of viral genomes can provide insight in HIV transmission routes in donors for whom risk behavior-based donor selection failed. STUDY DESIGN AND METHODS: This study includes all HIV-infected Dutch and Flemish donors in the period 2005 to 2014 (n = 55). Part of the HIV polymerase (pol) gene was amplified, sequenced, and compared with more than 10,000 HIV strains obtained from HIV-infected Dutch and Flemish patients...
May 2017: Transfusion
https://www.readbyqxmd.com/read/28370164/trends-in-age-and-red-blood-cell-donation-habits-among-several-racial-ethnic-minority-groups-in-the-united-states
#15
Mark H Yazer, Ralph Vassallo, Meghan Delaney, Marc Germain, Matthew S Karafin, Merlyn Sayers, Leo van de Watering, Beth H Shaz
BACKGROUND: To meet the needs of a diverse patient population, an adequate supply of red blood cells (RBCs) from ethnic/racial minority donors is essential. We previously described the 10-year changes in minority blood donation in the United States. This study describes donation patterns by donor status, age, and race/ethnicity. STUDY DESIGN AND METHODS: Data on the age and the number of unique black/African American, Hispanic/Latino, Asian, and white RBC donors were obtained from eight US blood collectors for 2006, 2009, 2012, and 2015...
March 28, 2017: Transfusion
https://www.readbyqxmd.com/read/28369183/smelling-is-telling-human-olfactory-cues-influence-social-judgments-in-semi-realistic-interactions
#16
Jessica M Gaby, Vivian Zayas
How does a person's smell affect others' impressions of them? Most body odor research asks perceivers to make social judgments based on armpit sweat without perfume or deodorant, presented on t-shirts. Yet, in real life, perceivers encounter fragranced body odor, on whole bodies. Our "raters" wore blindfolds and earplugs and repeatedly smelled same-sex "donors" in live interactions. In one condition, donors wore their normal deodorant and perfume ("diplomatic" odor) while in the other condition, donors were asked to avoid all outside fragrance influences ("natural" odor)...
March 29, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28369014/a-comparative-analysis-of-rhbmp-2-dbm-vs-icbg-for-secondary-alveolar-bone-grafts-in-patients-with-cleft-lip-and-palate-review-of-501-cases
#17
Jeffrey A Hammoudeh, Artur Fahradyan, Daniel D Gould, Fan Liang, Thomas Imahiyerobo, Leo Urbinelli, JoAnna T Nguyen, William Magee, Stephen Yen, Mark M Urata
BACKGROUND: Alveolar cleft reconstruction using iliac crest bone graft(ICBG) is considered standard of care for children with complete cleft lip and palate at the time of mixed dentition. Harvesting bone may result in donor site morbidity, additional operating time and length of hospitalization. Recombinant human bone morphogenetic protein(rhBMP)-2 with a demineralized bone matrix(DBM) was used as an alternative bone source for alveolar cleft reconstruction. We investigate the outcomes of rhBMP-2/DBM versus ICBG for alveolar cleft reconstruction by reviewing postoperative surgical complications and cleft closure...
March 31, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28363269/establishing-a-large-animal-model-for-in-vivo-reprogramming-of-bile-duct-cells-into-insulin-secreting-cells-to-treat-diabetes
#18
Caitlin Marie Hill, Anannya Banga, Juan E Abrahante, Ce Yuan, Lucas A Mutch, Jody Janecek, Timothy O'Brien, Melanie L Graham, James Dutton
Type I diabetes manifests in autoimmune destruction of beta cells requiring metabolic management with an exogenous replacement source of insulin, either by repeated injection of recombinant insulin or by transplantation of allogenic islets from cadaveric donors. Both of these approaches have severe limitations. Repeated insulin injection requires intensive blood glucose monitoring, is expensive, and is associated with decreased quality of life measures. Islet transplant, while highly effective, is severely limited by shortage of donor organs...
March 31, 2017: Human Gene Therapy. Clinical Development
https://www.readbyqxmd.com/read/28363122/trace-dna-evidence-dynamics-an-investigation-into-the-deposition-and-persistence-of-directly-and-indirectly-transferred-dna-on-regularly-used-knives
#19
Georgina E Meakin, Emma V Butcher, Roland A H van Oorschot, Ruth M Morgan
Empirical data on the transfer and persistence of trace DNA are crucial to the evaluation of forensic DNA evidence. This evaluation can be complicated by the occurrence of indirect DNA transfer; the possibility of which is well established, but research into such transfer is often focussed on unrealistic situations, e.g. handling of DNA-free items after participants have shaken hands for 1-2min. To simulate more realistic scenarios, this study investigated the deposition and persistence of both directly- and indirectly-transferred DNA on knives that had been artificially set up as 'regularly-used'...
March 21, 2017: Forensic Science International. Genetics
https://www.readbyqxmd.com/read/28361206/three-dimensional-replica-of-corrected-transposition-of-the-great-arteries-for-successful-heart-transplantation
#20
Tomoyuki Fujita, Satsuki Fukushima, Norihide Fukushima, Isao Shiraishi, Junjiro Kobayashi
A 59-year-old man who had been previously diagnosed with congenitally corrected transposition of the great arteries at the age of 35 years became a candidate for heart transplantation. At the age of 57 years, he was referred to our hospital and underwent implantation of a left ventricular assist device (EVAHEART; Sun Medical Technology Research Corp., Suwa City, Japan) because of worsening ventricular function and was listed as a heart transplant candidate. A donor appeared when the patient was 59 years. A three-dimensional replica was made using data from computed tomography angiography...
March 30, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
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