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https://www.readbyqxmd.com/read/29232079/behavioral-design-teams-the-next-frontier-in-clinical-delivery-innovation
#1
Ted Robertson, Matthew Darling, Jennifer Leifer, Owen Footer, Dani Gordski
Issue: A deep understanding of human behavior is critical to designing effective health care delivery models, tools, and processes. Currently, however, few mechanisms exist to systematically apply insights about human behavior to improve health outcomes. Behavioral design teams (BDTs) are a successful model for applying behavioral insights within an organization. Already operational within government, this model can be adapted to function in a health care setting. Goal: To explore how BDTs could be applied to clinical care delivery and review models for integrating these teams within health care organizations...
November 1, 2017: Issue Brief of the Commonwealth Fund
https://www.readbyqxmd.com/read/29230972/the-choice-pilot-project-challenges-of-implementing-a-combined-peer-work-and-shared-decision-making-programme-in-an-early-intervention-service
#2
Magenta B Simmons, Dominiek Coates, Samantha Batchelor, Tara Dimopoulos-Bick, Deborah Howe
AIM: Youth participation is central to early intervention policy and quality frameworks. There is good evidence for peer support (individuals with lived experience helping other consumers) and shared decision making (involving consumers in making decisions about their own care) in adult settings. However, youth programs are rarely tested or described in detail. This report aims to fill this gap by describing a consumer focused intervention in an early intervention service. METHODS: This paper describes the development process, intervention content and implementation challenges of the Choices about Healthcare Options Informed by Client Experiences and Expectations (CHOICE) Pilot Project...
December 12, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29230463/real-time-two-photon-lithography-in-controlled-flow-to-create-a-single-microparticle-array-and-particle-cluster-array-for-optofluidic-imaging
#3
Bing Xu, Yang Shi, Zhaoxin Lao, Jincheng Ni, Guoqiang Li, Yanlei Hu, Jiawen Li, Jiaru Chu, Dong Wu, Koji Sugioka
Microarray technology provides an excellent platform for biomedical and biochemical research including basic scientific studies, drug discovery, and diagnostics. Here, we develop a novel method referred to as real-time two-photon lithography in a controlled flow in which femtosecond laser two-photon lithography is performed in situ in the sequential mode stopping and flowing the flow of liquid resin containing microparticles to achieve 100% trapping on a one-bead-to-one-trap basis. Polydisperse particles can be all trapped to form a desired array by freely designing trap structures, resulting in an unprecedentedly high capture efficiency of ∼100%...
December 12, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29230307/who-parents-skills-training-pst-programme-for-children-with-developmental-disorders-and-delays-delivered-by-family-volunteers-in-rural-pakistan-study-protocol-for-effectiveness-implementation-hybrid-cluster-randomized-controlled-trial
#4
S U Hamdani, P Akhtar, Zill-E-Huma, H Nazir, F A Minhas, S Sikander, D Wang, C Servilli, A Rahman
Background: Development disorders and delays are recognised as a public health priority and included in the WHO mental health gap action programme (mhGAP). Parents Skills Training (PST) is recommended as a key intervention for such conditions under the WHO mhGAP intervention guide. However, sustainable and scalable delivery of such evidence based interventions remains a challenge. This study aims to evaluate the effectiveness and scaled-up implementation of locally adapted WHO PST programme delivered by family volunteers in rural Pakistan...
2017: Global Mental Health
https://www.readbyqxmd.com/read/29229171/special-considerations-in-pediatric-kidney-transplantation
#5
REVIEW
Sean A Hebert, Rita D Swinford, David R Hall, Jason K Au, John S Bynon
Universally accepted as the treatment of choice for children needing renal replacement therapy, kidney transplantation affords children the opportunity for an improved quality of life over dialysis therapy. Immunologic and surgical advances over the last 15 years have improved the pediatric patient and kidney graft survival. Unique to pediatrics, congenital genitourinary anomalies are the most common primary diseases leading to kidney failure, many with urological issues. Early urological evaluation for post-transplant bladder dysfunction and emphasis on immunization adherence are the mainstays of pediatric pretransplant and post-transplant evaluations...
November 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29228472/the-epidemiology-of-stroke-in-africa-a-systematic-review-of-existing-methods-and-new-approaches
#6
REVIEW
Mayowa Owolabi, Paul Olowoyo, Femi Popoola, Daniel Lackland, Carolyn Jenkins, Oyedunni Arulogun, Rufus Akinyemi, Odunayo Akinyemi, Onoja Akpa, Olanrewaju Olaniyan, Ezinne Uvere, Issa Kehinde, Anbesaw Selassie, Mulugeta Gebregziabher, Raelle Tagge, Bruce Ovbiagele
Accurate epidemiological surveillance of the burden of stroke is direly needed to facilitate the development and evaluation of effective interventions in Africa. The authors therefore conducted a systematic review of the methodology of stroke epidemiological studies conducted in Africa from 1970 to 2017 using gold standard criteria obtained from landmark epidemiological publications. Of 1330 articles extracted, only 50 articles were eligible for review grouped under incidence, prevalence, case-fatality, health-related quality of life, and disability-adjusted life-years studies...
December 11, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29226027/global-burden-of-skin-disease-inequities-and-innovations
#7
Divya Seth, Khatiya Cheldize, Danielle Brown, Esther F Freeman
Purpose of Review: We review the current understanding of the burden of dermatological disease through the lens of the Global Burden of Disease project, evaluate the impact of skin disease on quality of life in a global context, explore socioeconomic implications, and finally summarize interventions towards improving quality of dermatologic care in resource-poor settings. Recent Findings: The Global Burden of Disease project has shown that skin diseases continue to be the 4th leading cause of nonfatal disease burden world-wide...
September 2017: Current Dermatology Reports
https://www.readbyqxmd.com/read/29223005/the-emerging-role-of-systems-biology-for-engineering-protein-production-in-cho-cells
#8
REVIEW
Chih-Chung Kuo, Austin Wt Chiang, Isaac Shamie, Mojtaba Samoudi, Jahir M Gutierrez, Nathan E Lewis
To meet the ever-growing demand for effective, safe, and affordable protein therapeutics, decades of intense efforts have aimed to maximize the quantity and quality of recombinant proteins produced in CHO cells. Bioprocessing innovations and cell engineering efforts have improved product titer; however, uncharacterized cellular processes and gene regulatory mechanisms still hinder cell growth, specific productivity, and protein quality. Herein, we summarize recent advances in systems biology and data-driven approaches aiming to unravel how molecular pathways, cellular processes, and extrinsic factors (e...
December 6, 2017: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29221765/advances-in-fetal-echocardiography
#9
REVIEW
Helena M Gardiner
The development of fetal echocardiography and success in prenatal cardiac screening programs over the past 30 years has been driven by technical innovation and influenced by the different approaches of the various specialties practicing it. Screening for congenital heart defects no longer focuses on examining a limited number of pregnant women thought to be at increased risk, but instead forms an integrated part of a high-quality anatomical ultrasound performed in the second trimester using the 'five-transverse view' protocol...
December 5, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29221448/next-generation-sequencing-recent-applications-to-the-analysis-of-colorectal-cancer
#10
REVIEW
Filippo Del Vecchio, Valentina Mastroiaco, Antinisca Di Marco, Chiara Compagnoni, Daria Capece, Francesca Zazzeroni, Carlo Capalbo, Edoardo Alesse, Alessandra Tessitore
Since the establishment of the Sanger sequencing method, scientists around the world focused their efforts to progress in the field to produce the utmost technology. The introduction of next-generation sequencing (NGS) represents a revolutionary step and promises to lead to massive improvements in our understanding on the role of nucleic acids functions. Cancer research began to use this innovative and highly performing method, and interesting results started to appear in colorectal cancer (CRC) analysis. Several studies produced high-quality data in terms of mutation discovery, especially about actionable or less frequently mutated genes, epigenetics, transcriptomics...
December 8, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29221030/optical-camera-with-liquid-crystal-autofocus-lens
#11
T Galstian, O Sova, K Asatryan, V Presniakov, A Zohrabyan, M Evensen
A mobile phone camera with an innovative electrically tunable liquid crystal lens (TLCL) concept is demonstrated. We first report the comparative theoretical and experimental analyses of the performance of a traditional "modal control" TLCL versus a TLCL using a floating (unpowered) transparent electrode (FTE). It is shown that the appropriate choice of voltage and frequency values of the driving electric signal may improve significantly (almost twice) the optical quality of the lens using the FTE. Exceptionally low spherical aberrations of the lens (< λ/10 for up to 10 diopters of optical power) and high modulation transfer functions of a mobile phone camera (using those lenses for autofocus function) are demonstrated in a very simple operation mode (frequency tuning of the lens' optical power at a fixed driving voltage)...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220621/quality-of-life-in-australian-adults-aged-50-years-and-over-data-using-the-schedule-for-the-evaluation-of-individual-quality-of-life-seiqol-dw
#12
Sofia Robleda, Nancy A Pachana
OBJECTIVES: This study explored unique and personal domains associated with quality of life (QOL) in 153 mid-aged and older Australian adults over age 50, using an innovative measure of individualized QOL, the Schedule for the Evaluation of Individual Quality of Life (SEIQOL-DW). METHODS: Demographic measures as well as the SEIQOL-DW were administered. The qualitative responses on this scale were analyzed by Leximancer, a text analysis program that extracts semantic meaning and relational information automatically from text...
October 27, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29219076/-it-takes-more-than-a-fellowship-program-reflections-on-capacity-strengthening-for-health-systems-research-in-sub-saharan-africa
#13
EDITORIAL
Chimaraoke O Izugbara, Caroline W Kabiru, Djesika Amendah, Zacharie Tsala Dimbuene, Hermann Pythagore Pierre Donfouet, Esso-Hanam Atake, Marie-Gloriose Ingabire, Stephen Maluka, Joyce N Mumah, Matilu Mwau, Mollyne Ndinya, Kenneth Ngure, Estelle M Sidze, Charles Sossa, Abdramane Soura, Alex C Ezeh
Sub-Saharan Africa (SSA) experiences an acute dearth of well-trained and skilled researchers. This dearth constrains the region's capacity to identify and address the root causes of its poor social, health, development, and other outcomes. Building sustainable research capacity in SSA requires, among other things, locally led and run initiatives that draw on existing regional capacities as well as mutually beneficial global collaborations. This paper describes a regional research capacity strengthening initiative-the African Doctoral Dissertation Research Fellowship (ADDRF) program...
December 4, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29219008/powered-off-road-wheelchair-for-the-transportation-of-tetraplegics-along-mountain-trails
#14
Michele Gabrio Antonelli, Stefano Alleva, Pierluigi Beomonte Zobel, Francesco Durante, Terenziano Raparelli
PURPOSE: For off-road mobility, some manual or power assisted devices were conceived to be self-driven by paraplegics while for tetraplegics non power-assisted devices were conceived. These devices require one or more conductors who are subjected to a high physical demand thus potentially creating: precarious safety condition for the user an elevated physical demand of conductors could reduce the care and the attention to give to the user; the time of the outdoor adventure experience of the user could be limited...
December 8, 2017: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29218873/session-introduction-challenges-of-pattern-recognition-in-biomedical-data
#15
Shefali Setia Verma, Anurag Verma, Anna Okula Basile, Marta-Byrska Bishop, Christian Darabos
The analysis of large biomedical data often presents with various challenges related to not just the size of the data, but also to data quality issues such as heterogeneity, multidimensionality, noisiness, and incompleteness of the data. The data-intensive nature of computational genomics problems in biomedical informatics warrants the development and use of massive computer infrastructure and advanced software tools and platforms, including but not limited to the use of cloud computing. Our session aims to address these challenges in handling big data for designing a study, performing analysis, and interpreting outcomes of these analyses...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218714/using-a-service-design-model-to-develop-the-passport-to-safer-birth-in-nigeria-and-uganda
#16
Mariana Salgado, Melanie Wendland, Damaris Rodriguez, Meghan A Bohren, Olufemi T Oladapo, Olubunmi A Ojelade, Adebimpe A Olalere, Ronald Luwangula, Kidza Mugerwa, Bukola Fawole
OBJECTIVE: To demonstrate how a human-centered service design approach can generate practical tools for good-quality childbirth care in low-resource settings. METHODS: As part of the WHO "Better Outcomes in Labour Difficulty" (BOLD) project, a service design approach was used in eight Ugandan and Nigerian health facilities and communities to develop the "Passport to Safer Birth." There are three phases: Research for Design, Concept Design, and Detail Design. These generated design principles, design archetype personas, and Passport prototypes...
December 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29218710/turning-local-knowledge-and-experience-into-innovative-tools-for-quality-care-during-labor-and-childbirth-the-bold-project-experience
#17
EDITORIAL
Soo Downe, A Metin Gülmezoglu
No abstract text is available yet for this article.
December 7, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29218550/small-angle-scattering-historical-perspective-and-future-outlook
#18
Thomas M Weiss
Small angle scattering (SAS) is a powerful and versatile tool to elucidate the structure of matter at the nanometer scale. Recently, the technique has seen a tremendous growth of applications in the field of structural molecular biology. Its origins however date back to almost a century ago and even though the methods potential for studying biological macromolecules was realized already early on, it was only during the last two decades that SAS gradually became a major experimental technique for the structural biologist...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29218304/from-invention-to-innovation-risk-analysis-to-integrate-one-health-technology-in-the-dairy-farm
#19
Andrea Lombardo, Carlo Boselli, Simonetta Amatiste, Simone Ninci, Chiara Frazzoli, Roberto Dragone, Alberto De Rossi, Gerardo Grasso, Alberto Mantovani, Giovanni Brajon
Current Hazard Analysis Critical Control Points (HACCP) approaches mainly fit for food industry, while their application in primary food production is still rudimentary. The European food safety framework calls for science-based support to the primary producers' mandate for legal, scientific, and ethical responsibility in food supply. The multidisciplinary and interdisciplinary project ALERT pivots on the development of the technological invention (BEST platform) and application of its measurable (bio)markers-as well as scientific advances in risk analysis-at strategic points of the milk chain for time and cost-effective early identification of unwanted and/or unexpected events of both microbiological and toxicological nature...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29216596/understanding-social-and-behavioral-drivers-and-impacts-of-air-quality-sensor-use
#20
Bryan J Hubbell, Amanda Kaufman, Louie Rivers, Kayla Schulte, Gayle Hagler, Jane Clougherty, Wayne Cascio, Dan Costa
BACKGROUND: Lower-cost air quality sensors (hundreds to thousands of dollars) are now available to individuals and communities. This technology is undergoing a rapid and fragmented evolution, resulting in sensors that have uncertain data quality, measure different air pollutants and possess a variety of design attributes. Why and how individuals and communities choose to use sensors is arguably influenced by social context. For example, community experiences with environmental exposures and health effects and related interactions with industry and government can affect trust in traditional air quality monitoring...
December 4, 2017: Science of the Total Environment
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