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https://www.readbyqxmd.com/read/29329525/reporting-of-heterogeneity-of-treatment-effect-in-cohort-studies-a-review-of-the-literature
#1
Meryl Dahan, Caroline Scemama, Raphael Porcher, David J Biau
BACKGROUND: This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis. METHODS: prospective cohort studies, in English language, measuring the effect of a treatment (pharmacological, interventional, or other) published among 119 core clinical journals (defined by the National Library of Medicine) in the last 16 years were selected in the following data source: Medline...
January 12, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29310465/annals-express-predictive-role-of-tear-protein-expression-in-the-early-diagnosis-of-sj%C3%A3-gren-s-syndrome
#2
Piera Versura, Giuseppe Giannaccare, Gentiana Vukatana, Rita Mulè, Nazzarena Malavolta, Emilio Campos
BACKGROUND: The contribution of tear protein expression in patients with presumed diagnosis of Sjogren Syndrome (SS) is underestimated. We aimed to evaluate the role of tear proteins in the SS early diagnosis. METHODS: Charts from 110 patients suspected of SS were analyzed and the subsequent diagnosis retrieved. Subjective symptoms (Ocular Surface Disease Index, OSDI), tear film break-up time (TFBUT), Schirmer test, Jones test, Tear Clearance (TC), corneal (NEI score) and conjunctival staining (van Bjerstelveldt score), esthesiometry, cytology, tear protein analysis [total protein (TP) content, Lysozyme-C (LYS-C), Lactoferrin (LACTO), Lipocalin-1 (LIPOC-1) and Albumin (ALB)] were analyzed...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29281975/a-survey-of-prevalence-of-narrative-and-systematic-reviews-in-five-major-medical-journals
#3
Clovis Mariano Faggion, Nikolaos P Bakas, Jason Wasiak
BACKGROUND: Systematic reviews may provide less biased evidence than narrative reviews because they observe a strict methodology, similarly to primary studies. Hence, for clinical research questions, systematic reviews should be the study design of choice. It would be important to evaluate the prevalence and characteristics of narrative and systematic reviews published in prominent medical journals. Researchers and clinicians give great value to articles published in such scientific journals...
December 28, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29248089/health-care-use-and-status-among-abused-young-people
#4
Angela Diaz, Ken Peake, Anne Nucci-Sack, Viswanathan Shankar
BACKGROUND: Childhood abuse negatively affects young people's health. Little is known about its effect on health care usage patterns or on perception of health status during a life stage when learning to use care independently is a key developmental task. OBJECTIVES: In nonclinical study settings, abuse has been found to be associated with disorganized use of care and perceived poorer health. Our objective was to determine whether abused youth receiving health care had similar outcomes...
September 2017: Annals of Global Health
https://www.readbyqxmd.com/read/29216741/annals-express-evaluation-of-cellulose-pads-as-a-method-to-detect-cytomegalovirus-dna-in-neonatal-urine
#5
Florian Kipfmueller, Kira Jungbluth, Anna-Maria Eis-Hübinger, Ulrike Reber, Stefan Holdenrieder, Ulrich Gembruch, Peter Bartmann, Andreas Mueller
BACKGROUND: Several approaches exist to screen neonates for congenital cytomegalovirus (CMV) infection. We here describe a new method using cellulose pads for urine collection and its evaluation in an experimental and a clinical setting. METHODS: We systematically tested the effect of storage duration of the pads after exposure to CMV-positive urine, meconium contamination and specimen handling on the CMV load and the detection rate. Further, the method was tested in clinical practice in a cohort of 500 neonates...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29216190/quality-of-reporting-in-oncology-phase-ii-trials-a-5-year-assessment-through-systematic-review
#6
Julien Langrand-Escure, Romain Rivoirard, Mathieu Oriol, Fabien Tinquaut, Chloé Rancoule, Frank Chauvin, Nicolas Magné, Aurélie Bourmaud
BACKGROUND: Phase II clinical trials are a cornerstone of the development in experimental treatments They work as a "filter" for phase III trials confirmation. Surprisingly the attrition ratio in Phase III trials in oncology is significantly higher than in any other medical specialty. This suggests phase II trials in oncology fail to achieve their goal. Objective The present study aims at estimating the quality of reporting in published oncology phase II clinical trials. DATA SOURCES: A literature review was conducted among all phase II and phase II/III clinical trials published during a 5-year period (2010-2015)...
2017: PloS One
https://www.readbyqxmd.com/read/29209815/portrait-of-women-with-type-1-or-type-2-diabetes-of-childbearing-age-attending-diabetes-clinics-in-italy-the-amd-annals-initiative
#7
Marina Scavini, Maria Chiara Rossi, Marco Scardapane, Antonio Nicolucci, Valeria Manicardi, Giuseppina Russo, Paolo Di Bartolo, Carlo B Giorda, Nicoletta Musacchio, Antonio Ceriello, Stefano Genovese, Chiara Molinari, Nicoletta Dozio
AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age. METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin...
December 5, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29153028/annals-express-development-of-a-simple-indocyanine-green-measurement-method-using-an-automated-biochemical-analyzer
#8
Yuka Sato, Masanori Seimiya, Toshihiko Yoshida, Yuji Sawabe, Eisaku Hokazono, Susumu Osawa, Kazuyuki Matsushita
Background The indocyanine green (ICG) retention rate is important for assessing the severity of liver disorders. In the conventional method, blood needs to be collected twice. In the present study, we developed an automated ICG method that does not require blood sampling before intravenous ICG injections and is applicable to an automated biochemical analyzer. Methods The sera of 471 patients collected before and after intravenous ICG injections and submitted to the clinical laboratory of our hospital were used as samples...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29153026/annals-express-an-icp-ms-method-for-relative-free-copper-determination-and-generation-of-a-paediatric-reference-interval
#9
Patrick Wainwright, Daniel Wadey, Paul Cook
Background - Diagnosis of Wilson's disease is currently performed using caeruloplasmin as a first line screening test however this test has well described limitations. Monitoring of known Wilson's disease patients often uses 24 hour urine collection however this is inaccurate in children. Methods for directly measuring plasma free copper have been described but no reference interval data exist for a paediatric population. Methods - An ICP-MS method for measuring free copper was developed and validated, using ultracentrifugation...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29153025/annals-express-gestational-age-specific-reference-intervals-for-15-biochemical-measurands-during-normal-pregnancy-in-china
#10
Yanpeng Dai, Junjie Liu, Enwu Yuan, Yushan Lee, Quanxian Wang, Liting Jia, Linkai Wang, Yanhua Su
AIMS: Physiological changes that occur during pregnancy can influence biochemical parameters. Therefore, using reference intervals based on specimens from non-pregnant women to interpret laboratory results during pregnancy may be inappropriate. This study aimed to establish essential to establish reference intervals for a range of analytes during pregnancy. METHODS: The cross-sectional study was performed in 13656 healthy pregnant and 2634 non-pregnant women. Fifteen biochemical measurands relating to renal and hepatic function were analyzed using an Olympus AU5400 analyzer (Olympus, Tokyo, Japan)...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29097288/trend-over-time-in-hepatic-fibrosis-score-in-a-cohort-of-type-2-diabetes-patients
#11
Carlo Bruno Giorda, Gabriele Forlani, Roberta Manti, Arianna Mazzotti, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida, Barbara Tartaglino, Giuseppina Russo
AIMS: The prevalence and progression of hepatic fibrosis and its correlated factors in type 2 diabetes (T2DM) are poorly known. We aimed to define the percentage of T2DM patients who progress to fibrosis and the factors associated with disease progression. METHODS: Data from the electronic health records of 1527 patients with diagnosed T2DM and nonalcoholic fatty liver disease (NAFLD), as diagnosed by the Fatty Liver Index, were extracted from the AMD Annals database, which collects data from the Italian network of diabetes clinics...
October 31, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29065698/dysregulation-of-serum-microrna-574-3p-and-its-clinical-significance-in-hepatocellular-carcinoma
#12
Xianjuan Shen, Yajing Xue, Hui Cong, Xudong Wang, Shaoqing Ju
Objectives To explore microRNA-574-3p expression in serum of patients with hepatocellular carcinoma and investigate correlations between serum microRNA-574-3p expression and the development and prognosis of hepatocellular carcinoma. Design and methods Serum samples were collected from 70 patients with primary hepatocellular carcinoma, 40 patients with cirrhosis and 45 healthy controls. Serum microRNA-574-3p expression levels were detected by real-time quantitative polymerase chain reaction. The linearity, specificity and reproducibility were evaluated...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29058958/annals-express-biomarkers-in-mesothelioma
#13
David T Arnold, Nick Maskell
Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to diagnose and monitor. Numerous studies have attempted to identify a blood- or pleural fluid-based biomarker that could be used in the diagnostic pathway. More recently there has been interest in the ability of serum/plasma biomarkers to monitor mesothelioma, given development of newer treatments, and limitations of radiological assessment. The majority of research has focused on soluble mesothelin (SM), a soluble glycoprotein expressed by mesothelial cells...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29027807/biochemistry-of-the-menopause
#14
John W Honour
The life of a human female is characterized from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the perimenopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28990817/annals-express-a-combined-liquid-chromatography-tandem-mass-spectrometry-assay-for-the-quantification-of-urinary-oxalate-and-citrate-for-diagnosis-and-management-of-nephrolithiasis
#15
David John Marshall, Joanne Elaine Adaway, Brian G Keevil
Background 24 hour urine citrate and oxalate analysis is important in the screening and monitoring of patients with nephrolithiasis. To streamline the analytical process it was decided to combine oxalate and citrate and analyse them simultaneously in the same assay. Objective A highly sensitive and specific assay for analysis of urine citrate and oxalate was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with a simple weak anion exchange solid phase extraction (WAX SPE) clean up procedure...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28939716/resistant-hypertension-time-updated-blood-pressure-values-and-renal-outcome-in-type-2-diabetes-mellitus
#16
Francesca Viazzi, Pamela Piscitelli, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Salvatore De Cosmo, Roberto Pontremoli
BACKGROUND: Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes mellitus (T2D) and entails worse cardiovascular prognosis. The impact of aTRH and long-term achievement of recommended blood pressure (BP) values on renal outcome remains largely unknown. We assessed the role of aTRH and BP on the development of chronic kidney disease in patients with T2D and hypertension in real-life clinical practice. METHODS AND RESULTS: Clinical records from a total of 29 923 patients with T2D and hypertension, with normal baseline estimated glomerular filtration rate and regular visits during a 4-year follow-up, were retrieved and analyzed...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28930781/is-article-methodological-quality-associated-with-conflicts-of-interest-an-analysis-of-the-plastic-surgery-literature
#17
Brian H Cho, Joseph Lopez, Jessica Means, Sandra Lopez, Jacqueline Milton, Anthony P Tufaro, James W May, Amir H Dorafshar
PURPOSE: Conflicts of interest (COI) are an emerging area of discussion within the field of plastic surgery. Recently, several reports have found that research studies that disclose COI are associated with publication of positive outcomes. We hypothesize that this association is driven by higher-quality studies receiving industry funding. This study aimed to investigate the association between industry support and study methodological quality. METHODS: We reviewed all entries in Plastic and Reconstructive Surgery, Annals of Plastic Surgery, and Journal of Plastic, Reconstructive, and Aesthetic Surgery within a 1-year period encompassing 2013...
December 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28920468/annals-express-macrocomplexes-and-discordant-high-sensitivity-cardiac-troponin-concentrations
#18
Pete Kavsak, Chantele Roy, Paul Malinowski, Ching-Tong Mark, Terry Scott, Lorna Clark, Shana Lamers, Craig Ainsworth
BACKGROUND: Analytical comparisons between different high-sensitivity cardiac troponin (hs-cTn) assays are important for reassurance of results performed with different methodologies and to identify potential interferences or confounders to result interpretation. Our objective in the present study was to compare Beckman Coulter's latest hs-cTnI assay to Abbott's hs-cTnI assay and to assess agreement between results. METHODS: Two hundred EDTA plasma samples that had clinically reported hs-cTnI results from the Abbott ARCHITECTi2000 that spanned the analytical range were stored (median=4h), re-centrifuged and retested for hs-cTnI on the Abbott ARCHITECTi1000 and Beckman Coulter Access2 analyzers...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28853295/annals-express-influence-of-cytochrome-p450-genotype-on-the-plasma-disposition-of-prochlorperazine-metabolites-and-their-relationships-with-clinical-responses-in-cancer-patients
#19
Masaki Tashiro, Takafumi Naito, Yoshiyuki Kagawa, Junichi Kawakami
BACKGROUND: Oral prochlorperazine, a dopamine D2 receptor antagonist, is largely metabolized to sulfoxide, 7-hydroxylate, and N-desmethylate by cytochrome P450s (CYPs). This study evaluated the influence of CYP genotype on the plasma dispositions of prochlorperazine and its metabolites and their relationships with antiemetic efficacy and prolactin elevation in cancer patients. METHODS: Forty-eight cancer patients treated with oral prochlorperazine were enrolled...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28814103/annals-express-associations-between-glycaemic-control-and-activation-of-the-renin-angiotensin-aldosterone-system-in-participants-with-type-2-diabetes-mellitus-and-hypertension
#20
Tomas Patrick Griffin, Deirdre Wall, Gerard A Browne, Michael C Dennedy, Paula O'Shea
INTRODUCTION: Hyperglycaemia increases succinate levels and succinate receptor (GPR91) activation in the kidney resulting in renin release. The aim of our study was to determine if there is an association between glycaemic control as evidenced by glycated haemoglobin (HbA1c) values and activation of the renin-angiotensin-aldosterone-system in patients with type 2 diabetes mellitus (T2DM) and hypertension. METHODS: A cross-sectional study was conducted at Galway University Hospitals between December 2014 and March 2015...
January 1, 2017: Annals of Clinical Biochemistry
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