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https://www.readbyqxmd.com/read/29792048/annals-express-a-novel-high-throughput-assay-for-the-measurement-of-salivary-progesterone-by-liquid-chromatography-tandem-mass-spectrometry
#1
Lina Schiffer, Joanne Elaine Adaway, Elizabeth S Baranowski, Wiebke Arlt, Brian G Keevil
BACKGROUND: Liquid chromatography tandem mass spectrometry (LC-MS/MS) enables specific and sensitive quantification of steroids with a high-throughput. Saliva sampling is advantageous for multi-sample profiling over longer periods of time as it is non-invasive, cheap, can be carried out at home and does not require the attendance of clinical personnel. We developed a rapid LC-MS/MS for the measurement of salivary progesterone, frequently assessed as ovulation marker in patients desiring fertility...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29792047/annals-express-phenotyping-and-relative-quantification-of-vitamin-d-binding-protein-in-a-pediatric-population-by-liquid-chromatography-tandem-mass-spectrometry
#2
Ana Isabel Cillero, Eduardo Martínez-Morillo, Laura Mantecón, Mª Agustina Alonso, Helena Gil-Peña, Fernando Santos, Francisco V Alvarez
BACKGROUND: Adequate levels of vitamin D are required to ensure bone health and minimize the incidence of multiple extraskeletal diseases. Although total 25-hydroxyvitamin D (25OHD) remains the recommended biomarker for assessing vitamin D status, it has been speculated that free 25OHD correlates better with clinical outcomes. The calculation of free 25OHD depends on the levels of vitamin D binding protein (DBP), the determination of which involves different immunoassays and has led to varying results and conclusions...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29703104/annals-express-establishment-of-a-simpler-method-for-measuring-hdl-micrornas
#3
Hiroaki Ishikawa, Hiroya Yamada, Kanako Kondo, Takeru Ota, Mirai Yamazaki, Yoshitaka Ando, Genki Mizuno, Eiji Munetsuna, Koji Suzuki, Ryoji Teradaira, Koji Ohashi
BACKGROUND: MicroRNAs are present not only in exosomes but also in high-density lipoprotein (HDL) and have the potential as biomarkers for various diseases. Various purification methods have been developed to quantify HDL-miRNAs; however, they are unsuitable for clinical applications. Therefore, we aimed to establish a simpler analytical method to quantify HDL-miRNAs for clinical applications. METHODS: We purified HDL fraction from pooled plasma using a three-step protocol consisting of ultracentrifugation, phosphotungstic acid/MgCl2 precipitation, and desalting/buffer exchange followed by the quantification of HDL-miRNAs by qRT-PCR...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29698970/apparent-treatment-resistant-hypertension-blood-pressure-control-and-the-progression-of-chronic-kidney-disease-in-patients-with-type-2-diabetes
#4
Francesca Viazzi, Eulalia Greco, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Salvatore De Cosmo, Roberto Pontremoli
BACKGROUND/AIMS: Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD). The impact of aTRH and achievement of recommended blood pressure (BP) values on the rate of glomerular filtration rate (eGFR) loss in CKD patients is poorly known. To assess the role of aTRH and time-updated BP control (BPC) on the progression of CKD in patients with T2D and hypertension (HT) in real life clinical practice. METHODS: Clinical records from a total of 2,778 diabetic patients with HT and stage 3 CKD (i...
March 16, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29677050/changes-in-albuminuria-and-renal-outcome-in-patients-with-type-2-diabetes-and-hypertension-a-real-life-observational-study
#5
Francesca Viazzi, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Eulalia Greco, Salvatore De Cosmo, Roberto Pontremoli
OBJECTIVES: To assess the predictive role of changes in albuminuria on the loss of renal function under antihypertensive treatment in patients with type 2 diabetes (T2D). METHODS: Clinical records from a total of 12 611 patients with hypertension and T2D, attending 100 antidiabetic centers in Italy, with normal estimated glomerular filtration rate (eGFR) at baseline and regular visits during a 4-year period were retrieved and analyzed. We assessed the association between changes in albuminuria status during a 1-year baseline period and time updated blood pressure (BP) and eGFR loss over the subsequent 4-year follow-up...
April 19, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29660996/annals-express-a-case-of-hereditary-coproporphyria-with-posterior-reversible-encephalopathy-and-novel-cpox-gene-mutation-c-863t-g-p-leu288trp
#6
Deborah Lambie, Christopher M Florkowski, Chris Sies, Anthony Raizis, Wai-Kwan Siu, Cindy Towns
A 21 year old female had recurrent presentations to the Emergency Department (ED) with myalgia, vomiting, abdominal pain and subsequently developed generalized seizures. She was volume depleted with a plasma sodium of 125 mmol/L (reference interval 135-145) and she had fluctuating hypertension. Acute porphyria was suspected and confirmed with raised urine porphobilinogen (PBG)/creatinine ratio of 12·4 umol/mmol (reference interval < 1·5) and she was treated with intravenous haem arginate. Urinary porphyrin/creatinine ratio was 673 nmol/mmol, (reference interval <35) and faecal porphyrins 2430 umol/kg dry weight (reference interval <200) were markedly elevated, with raised faecal CIII:CI ratio, consistent with acute coproporphyria...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29621657/the-100-most-cited-papers-in-general-thoracic-surgery-a-bibliography-analysis
#7
REVIEW
Hongdou Ding, Xiao Song, Linsong Chen, Xinlin Zheng, Gening Jiang
BACKGROUND: The status of citations can reflect the impact of a paper and its contribution to surgical practice. The aim of our study was to identify and review the 100 most-cited papers in general thoracic surgery. MATERIALS AND METHODS: Relevant papers on general thoracic surgery were searched through Thomson Reuters Web of Science in the last week of November 2017. Results were returned in descending order of total citations. Their titles and abstracts were reviewed to identify whether they met our inclusion criteria by two thoracic surgeons independently...
April 2, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29590329/association-of-author-gender-with-sex-bias-in-surgical-research
#8
Nicholas Xiao, Neel A Mansukhani, Diego F Mendes de Oliveira, Melina R Kibbe
Importance: Previous studies demonstrate sex bias in surgical research. Female participants and investigators are underrepresented in surgical scientific research. Objectives: To describe the distribution of male and female authors in 5 general-interest surgery journals, assess the association of author gender with sex bias, and explore whether investigators benefit from performing sex-inclusion research. Design, Setting, and Participants: For this bibliometric analysis, data were abstracted from 1921 original, peer-reviewed articles published from January 1, 2011, through December 31, 2012, in Annals of Surgery, American Journal of Surgery, JAMA Surgery, The Journal of Surgical Research, and Surgery...
March 28, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29534614/analytical-evidence-to-show-letters-impregnated-with-novel-psychoactive-substances-are-a-means-of-getting-drugs-to-inmates-within-the-uk-prison-service
#9
Loretta T Ford, Jonathan D Berg
Introduction Novel psychotropic substances also known as legal highs are a major concern in UK prisons, fuelling violence and putting a strain on resources for inmates requiring medical treatment for adverse effects. We provide a clinical toxicology service including routine screening for novel psychoactive substances. In 2015, we were approached by Her Majesty Prison Service search dog training team to advise on which novel psychoactive substances to target, and again in 2016 to further provide analytical support to test five letters which the dogs positively identified for novel psychotropic substances during routine searches of prison mail rooms...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29534610/development-of-a-rapid-liquid-chromatography-tandem-mass-spectrometry-method-for-the-quantitation-of-serum-dexamethasone-and-its-clinical-verification
#10
James M Hawley, Laura J Owen, Miguel Debono, John Newell-Price, Brian G Keevil
Background Measurement of serum dexamethasone during the overnight dexamethasone-suppression test has been recommended to reduce false-positive results when investigating Cushing's syndrome or increasingly commonly found adrenal incidentalomas. Despite this, there remains a paucity of well-validated dexamethasone methods currently available. Here, we describe the development of a rapid and sensitive liquid chromatography tandem mass spectrometry serum dexamethasone assay and verify its utility in a cohort of postmenopausal females...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29496500/update-in-outpatient-general-internal-medicine-practice-changing-evidence-published-in-2017
#11
REVIEW
Mark L Wieland, Jason H Szostek, Majken T Wingo, Jason A Post, Karen F Mauck
Clinicians are challenged to identify new practice-changing articles in the medical literature. To identify the practice-changing articles published in 2017 most relevant to outpatient general internal medicine, 5 internists reviewed the following sources: 1) titles and abstracts from internal medicine journals with the 7 highest impact factors, including New England Journal of Medicine, Lancet, Journal of the American Medical Association, British Medical Journal, Public Library of Science Medicine, Annals of Internal Medicine, and JAMA Internal Medicine; 2) synopses and syntheses of individual studies, including collections in the American College of Physicians Journal Club, Journal Watch, and Evidence-Based Medicine; 3) databases of synthesis, including Evidence Updates and the Cochrane Library...
February 26, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29444593/validation-of-an-automated-ultraperformance-liquid-chromatography-igg-n-glycan-analytical-method-applicable-to-classical-galactosaemia
#12
Hugh Owen Colhoun, Eileen P Treacy, Marguerite MacMahon, Pauline M Rudd, Maria Fitzgibbon, Roisin O'Flaherty, Karolina M Stepien
Background Classical galactosaemia (OMIM #230400) is a rare disorder of carbohydrate metabolism caused by deficiency of the galactose-1-phosphate uridyltransferase enzyme. The pathophysiology of the long-term complications, mainly cognitive, neurological and female fertility problems, remains poorly understood. Current clinical methods of biochemical monitoring lack precision and individualization with an identified need for improved biomarkers for this condition. Methods We report the development and detailed validation of an automated ultraperformance liquid chromatography N-glycan analytical method of high peak resolution applied to galactose incorporation into human serum IgG...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29433324/letter-in-response-to-john-w-honour-standardization-of-steroid-tests-and-implications-for-the-endocrine-community-annals-of-clinical-biochemistry-vol-54-6-618-630
#13
https://www.readbyqxmd.com/read/29408245/history-of-the-southern-thoracic-surgical-association-president-s-award-for-best-scientific-paper
#14
Constantine Mavroudis
The President's Award for best scientific paper is presented to esteemed members at each Southern Thoracic Surgical Association annual meeting to stimulate friendly scientific competition. Between 1964 and 2015, 58 awards were presented for clinical expertise in general thoracic surgery (18), adult cardiac surgery (25), and congenital heart surgery (15). Manuscripts were published by The Annals of Thoracic Surgery, and the average number of subsequent citations in professional medical journals as a measure of scientific importance was 43...
May 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29394888/diabetic-kidney-disease-in-the-elderly-prevalence-and-clinical-correlates
#15
Giuseppina T Russo, Salvatore De Cosmo, Francesca Viazzi, Antonio Mirijello, Antonio Ceriello, Pietro Guida, Carlo Giorda, Domenico Cucinotta, Roberto Pontremoli, Paola Fioretto
BACKGROUND: Diabetic kidney disease (DKD) is a major burden in elderly patients with type 2 diabetes (T2DM). Low estimated glomerular filtration rate (eGFR+, < 60 mL/min/1.73 m2) and albuminuria (Alb+) are essential for the diagnosis of DKD, but their association with clinical variables and quality of care may be influenced by ageing. METHODS: Here we investigated the association of clinical variables and quality of care measures with eGFR+ and Alb+ in 157,595 T2DM individuals participating to the Italian Association of Clinical Diabetologists (AMD) Annals Initiative, stratified by age...
February 2, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29357677/diagnostic-and-prognostic-potential-of-serum-mir-132-212-cluster-in-patients-with-hepatocellular-carcinoma
#16
Feng Wang, Jun Wang, Linlin Ju, Lin Chen, Weihua Cai, Jialin Yang
Background It has been reported that both of the miR-132/212 (micro-RNA) cluster members, miR-132 and miR-212, are downregulated in hepatocellular carcinoma. Nevertheless, the expression pattern and clinical utility of serum miR-132/212 in hepatocellular carcinoma are still unknown. Methods In this study, serum concentrations of miR-132 and miR-212 were measured in 80 hepatocellular carcinoma patients, 51 controls with chronic liver diseases and 42 healthy volunteers by using quantitative real-time polymerase chain reaction...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29349293/experimenter-gender-and-replicability-in-science
#17
REVIEW
Colin D Chapman, Christian Benedict, Helgi B Schiöth
There is a replication crisis spreading through the annals of scientific inquiry. Although some work has been carried out to uncover the roots of this issue, much remains unanswered. With this in mind, this paper investigates how the gender of the experimenter may affect experimental findings. Clinical trials are regularly carried out without any report of the experimenter's gender and with dubious knowledge of its influence. Consequently, significant biases caused by the experimenter's gender may lead researchers to conclude that therapeutics or other interventions are either overtreating or undertreating a variety of conditions...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29329525/reporting-of-heterogeneity-of-treatment-effect-in-cohort-studies-a-review-of-the-literature
#18
Meryl Dahan, Caroline Scemama, Raphael Porcher, David J Biau
BACKGROUND: This article corresponds to a literature review and analyze how heterogeneity of treatment (HTE) is reported and addressed in cohort studies and to evaluate the use of the different measures to HTE analysis. METHODS: prospective cohort studies, in English language, measuring the effect of a treatment (pharmacological, interventional, or other) published among 119 core clinical journals (defined by the National Library of Medicine) in the last 16 years were selected in the following data source: Medline...
January 12, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29310465/predictive-role-of-tear-protein-expression-in-the-early-diagnosis-of-sj%C3%A3-gren-s-syndrome
#19
Piera Versura, Giuseppe Giannaccare, Gentiana Vukatana, Rita Mulè, Nazzarena Malavolta, Emilio C Campos
Background The contribution of tear protein expression in patients with presumed diagnosis of Sjögren syndrome is underestimated. We aimed to evaluate the role of tear proteins in the Sjögren syndrome early diagnosis. Methods Charts from 110 patients suspected of Sjögren syndrome were analysed and the subsequent diagnosis retrieved. Subjective symptoms (ocular surface disease index, OSDI), tear film break-up time (TFBUT), Schirmer test, Jones test, tear clearance (TC), corneal (NEI score) and conjunctival staining (van Bjerstelveldt score), esthesiometry, cytology, tear protein analysis (total protein [TP] content, lysozyme-C [LYS-C], lactoferrin [LACTO], lipocalin-1 [LIPOC-1] and albumin [ALB]) were analysed...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29281975/a-survey-of-prevalence-of-narrative-and-systematic-reviews-in-five-major-medical-journals
#20
Clovis Mariano Faggion, Nikolaos P Bakas, Jason Wasiak
BACKGROUND: Systematic reviews may provide less biased evidence than narrative reviews because they observe a strict methodology, similarly to primary studies. Hence, for clinical research questions, systematic reviews should be the study design of choice. It would be important to evaluate the prevalence and characteristics of narrative and systematic reviews published in prominent medical journals. Researchers and clinicians give great value to articles published in such scientific journals...
December 28, 2017: BMC Medical Research Methodology
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