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https://www.readbyqxmd.com/read/28032449/occurrence-over-time-and-regression-of-nonalcholic-fatty-liver-disease-in-type-2-diabetes
#1
Carlo Giorda, Gabriele Forlani, Roberta Manti, Natalia Mazzella, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Giuseppina Russo, Paolo Di Bartolo, Antonio Ceriello, Piero Guida
BACKGROUND: This analysis was aimed to assess the incidence, regression, and correlated factors of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes, which are poorly known. METHODS: NAFLD (defined as fatty liver index [FLI] score ≥60) in patients with type 2 diabetes and related factors was investigated in a nationwide database containing information from the Italian network of diabetes clinics. A 10% variation of FLI was the cut-off considered in the analyses of a cohort of 5030 patients which was separately conducted for those who developed, maintained or recovered from FLI-assessed NAFLD (FLI-NAFLD) over a 3-year period...
December 29, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28032302/the-1925-diphtheria-antitoxin-run-to-nome-alaska-a-public-health-illustration-of-human-animal-collaboration
#2
Basil H Aboul-Enein, William C Puddy, Jacquelyn E Bowser
Diphtheria is an acute toxin-mediated superficial infection of the respiratory tract or skin caused by the aerobic gram-positive bacillus Corynebacterium diphtheriae. The epidemiology of infection and clinical manifestations of the disease vary in different parts of the world. Historical accounts of diphtheria epidemics have been described in many parts of the world since antiquity. Developed in the late 19th century, the diphtheria antitoxin (DAT) played a pivotal role in the history of public health and vaccinology prior to the advent of the diphtheria-tetanus toxoids and acellular pertussis (DTaP) vaccine...
December 29, 2016: Journal of Medical Humanities
https://www.readbyqxmd.com/read/28030676/aortic-stenosis
#3
Faisal G Bakaeen, Todd K Rosengart, Blase A Carabello
This issue provides a clinical overview of aortic stenosis, focusing on screening, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27956461/annals-express-l-dopa-therapy-interferes-with-urine-catecholamine-analysis-in-children-with-suspected-neuroblastoma-a-case-series
#4
Alison Kelly, Rajeev Srivastava, Ellie Dow, D Fraser Davidson
Neuroblastoma is the most common extracranial malignancy diagnosed in childhood. Clinical presentation is variable, and metastatic disease is common at diagnosis. Analyses of urinary catecholamines and their metabolites are commonly requested as a first-line investigation when clinical suspicion exists. Levodopa (L-Dopa) therapy is utilised as a treatment for a number of disorders in childhood, including Dopa-responsive dystonia. Neuroblastoma may mimic some of the clinical features of this disorder. L-Dopa can interfere with analysis of urinary catecholamines and their metabolites, and complicate interpretation of results...
December 12, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27941128/annals-express-development-of-a-liquid-chromatography-tandem-mass-spectrometry-method-for-the-simultaneous-measurement-of-voriconazole-posaconazole-and-itraconazole
#5
John Michael Wadsworth, Anna M Milan, James Anson, Andrew Stuart Davison
BACKGROUND: Azole based antifungals are the first line therapy for some of the most common mycoses and are now also being used prophylactically to protect immunocompromised patients. However due to variability in both their metabolism and bioavailability, therapeutic drug monitoring is essential to avoid toxicity but still gain maximum efficacy. METHODS: Following protein precipitation with acetonitrile, 20 µL of extract was injected onto a 2.1x50mm Waters Atlantis dC18 3 µm column...
December 8, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27938574/-effects-of-neoadjuvant-chemoradiotherapy-on-the-rates-of-sphincter-preserving-surgery-in-lower-rectal-cancer-and-analysis-of-their-prognostic-factors
#6
X J Wang, P Chi, H M Lin, X R Lu, Y Huang, Z B Xu, S H Huang, Y W Sun, D X Ye
Objectives: To identify independent factors of sphincter preserving surgery, and to evaluated whether preoperative chemoradiotherapy (CRT) improves the sphincter preservation rate for lower rectal cancers. Methods: A total of 541 consecutive patients who underwent curative surgery for locally advanced rectal cancer (cT3-4Nx or cTxN+ ) within 6 cm of the anal verge with or without neoadjuvant CRT in Department of Colorectal Surgery, Union Hospital, Fujian Medical University between September 2000 and September 2013 were reviewed...
1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27935651/epidemiology-of-diabetic-kidney-disease-in-adult-patients-with-type-1-diabetes-in-italy-the-amd-annals-initiative
#7
Antonio Pacilli, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De Cosmo
BACKGROUND: Patients with type 1 diabetes mellitus are at increased risk of death. This risk appears to be modulated by kidney dysfunction. Aim of this study was to evaluate the prevalence of diabetic kidney disease (DKD), its traits and clinical correlates in a large sample of patients with type 1 diabetes. METHODS: Clinical data of 20,464 patients with type 1 diabetes were extracted from electronic medical records. Estimated glomerular filtration rate (eGFR) and increased urinary albumin excretion were considered...
December 9, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27919097/preoperative-evaluation-for-noncardiac-surgery
#8
Steven L Cohn
This issue provides a clinical overview of preoperative evaluation for noncardiac surgery, focusing on risk factors, elements of evaluation, medication management, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
December 6, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27884661/association-of-kidney-disease-measures-with-risk-of-renal-function-worsening-in-patients-with-hypertension-and-type-2-diabetes
#9
Francesca Viazzi, Pamela Piscitelli, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina T Russo, Paola Fioretto, Pietro Guida, Salvatore De Cosmo, Roberto Pontremoli
AIMS: To assess the role of kidney disease measures on the development of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and hypertension (HT). METHODS: Clinical records from a total of 17,160 patients with T2D and HT, a baseline estimated glomerular filtration rate (eGFR) values ≥60mL/min/1.73m(2), evaluation for albuminuria and regular visits during a four-year follow-up were retrieved and analyzed. The incidence of eGFR <60mL/min/1.73m(2) and/or a reduction >30% from baseline was evaluated...
October 29, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27855102/non-inferiority-trials-are-they-inferior-a-systematic-review-of-reporting-in-major-medical-journals
#10
Sunita Rehal, Tim P Morris, Katherine Fielding, James R Carpenter, Patrick P J Phillips
OBJECTIVE: To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. DESIGN: Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medicine, Annals of Internal Medicine, BMJ, JAMA, Lancet and New England Journal of Medicine)...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27810997/annals-express-clinical-significance-of-gcf-sil-6r-and-calprotectin-to-evaluate-the-periodontal-inflammation
#11
Yukari Kajiura, Jung Hwan Lew, Takahisa Ikuta, Yasufumi Nishikawa, Jun-Ichi Kido, Toshihiko Nagata, Koji Naruishi
BACKGROUND: Periodontitis is a inflammatory disease. The aim of this study was to investigate whether soluble form of interleukin-6 receptor (sIL-6R) and calprotectin levels in gingival crevicular fluid (GCF) are useful bio-marker to evaluate the periodontitis. METHODS: At first, cross-sectional study was performed. A total of 34 periodontitis patients were enrolled and the GCF samples were collected from healthy and inflamed sites of periodontal pockets in each patient...
November 3, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27810996/annals-express-stability-of-ionized-calcium-measurements-at-concentrations-less-than-0-3-mmol-l-by-point-of-care-blood-gas-instruments-application-for-post-filter-calcium-quality-control-in-patients-with-citrate-anticoagulation-during-extracorporeal-circulation
#12
Maria Averina, Raymond Jakobsen
: BackgroundMeasurements of ionized calcium (Ca(2)(+)) at concentrations less than 0.3 mmol/L are required for post-filter control in patients that receive extracorporeal circulation with sodium citrate anticoagulation. This study evaluates the stability of the Ca(2)(+) measurements at such concentrations. MethodsThe stability of the Ca(2)(+) measurements was tested by measuring daily the external standard Qualicheck concentration 3 s7950, Radiometer (0.22-0.25 mmol/L) by blood gas instruments ABL800 and ABL90, Radiometer...
November 3, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27802475/giant-cell-arteritis
#13
Gary S Hoffman
This issue provides a clinical overview of giant cell arteritis, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
November 1, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27799298/annals-express-uptake-of-recommended-common-reference-intervals-for-chemical-pathology-in-australia
#14
Graham Jones, Sabrina Koetsier
BackgroundReference intervals are a vital part of reporting numerical pathology results. It is known however that variation in reference intervals between laboratories is common, even when analytical methods support common reference intervals. In response to this in Australia, the Australasian Association of Clinical Biochemists (AACB) together with the Royal College of Pathologists of Australasia (RCPA) published in 2014 a set of recommended common reference intervals for twelve common serum analytes (sodium, potassium, chloride, bicarbonate, creatinine male, creatinine female, calcium, calcium adjusted for albumin, phosphate, magnesium, lactate dehydrogenase, alkaline phosphatase, total protein)...
October 31, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27755483/predictors-of-chronic-kidney-disease-in-type-2-diabetes-a-longitudinal-study-from-the-amd-annals-initiative
#15
Salvatore De Cosmo, Francesca Viazzi, Antonio Pacilli, Carlo Giorda, Antonio Ceriello, Sandro Gentile, Giuseppina Russo, Maria C Rossi, Antonio Nicolucci, Pietro Guida, Roberto Pontremoli
: The identification of clinical predictors for the development of chronic kidney disease is a critical issue in the management of patients with type 2 diabetes mellitus.We evaluated 27,029 patients with type 2 diabetes mellitus and estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m and normoalbuminuria from the database of the Italian Association of Clinical Diabetologists network. Primary outcomes were eGFR <60 mL/min/1.73 m and normoalbuminuria; albuminuria and eGFR ≥60 mL/min/1...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27742851/annals-express-the-role-of-calculated-non-caeruloplasmin-bound-copper-in-wilson-s-disease
#16
Andrew Duncan, Calum Yacoubian, Robert Beetham, Anthony Catchpole, David Bullock
BACKGROUND: US and European guidelines suggest the use of calculated non-caeruloplasmin bound copper (free copper index) for the diagnosis and management of Wilson's Disease. However, there is concern that the required analytical measurements of caeruloplasmin and copper may not be sufficiently robust at the concentrations usually found. METHODS: Aliquots of six plasma specimens were sent to laboratories participating in the UK National External Quality Assessment Scheme for copper and caeruloplasmin...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27742848/vitamin-d-binding-protein-as-it-is-understood-in-2016-is-it-a-critical-key-with-which-to-help-to-solve-the-calcitriol-conundrum
#17
REVIEW
R X Davey
BACKGROUND: The misnamed 'vitamin' D is actually the hormone calcitriol (1,25 dihydroxyhydroxyvitamin D). It has a central regulatory role in calcium metabolism, and more widely in the immune system. The prohormone calcifediol (25 hydroxyvitamin D) is more easily measured in the laboratory and is the analyte used in reference interval formulation. Being highly lipid soluble, both calcifediol and calcitriol travel in the bloodstream on carriage proteins, principally on vitamin D-binding protein...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27716793/outcomes-definitions-and-statistical-tests-in-oncology-studies-a-systematic-review-of-the-reporting-consistency
#18
Romain Rivoirard, Vianney Duplay, Mathieu Oriol, Fabien Tinquaut, Franck Chauvin, Nicolas Magne, Aurelie Bourmaud
BACKGROUND: Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. METHODS: From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC)...
2016: PloS One
https://www.readbyqxmd.com/read/27705887/annals-express-chitotriosidase-enzyme-activity-is-this-a-possible-chronic-inflammation-marker-in-children-with-common-variable-immunodeficiency-and-early-atherosclerosis
#19
Elif Azarsız, Neslihan Karaca, Erturk Levent, Necil Kutukculer, Eser Sozmen
BACKGROUND: Common variable immunodeficiency (CVID) is a rare clinically symptomatic primary immunodeficiency disorder which manifests a wide variability of symptoms, complications. Atherosclerosis in CVID patients have not been investigated yet contrary to other severe clinical complications. We aimed to investigate the chitotriosidase enzyme's role as an inflammation and atherosclerosis marker in pediatric CVID patients. METHODS: CVID patients (n =24) and healthy controls (n = 23) evaluated for chitotriosidase activity with other inflammation markers (hsCRP, myeloperoxidase, serum amyloid A, ferritin), lipid profile and echocardiographic findings (carotid artery intima media thickness - cIMT, brachial artery flow-mediated vazodilatation - FMD%)...
October 4, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27699401/depression
#20
Robert M McCarron, Erik R Vanderlip, Jeffrey Rado
This issue provides a clinical overview of depression, focusing on screening, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
October 4, 2016: Annals of Internal Medicine
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