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https://www.readbyqxmd.com/read/29097288/trend-over-time-in-hepatic-fibrosis-score-in-a-cohort-of-type-2-diabetes-patients
#1
Carlo Bruno Giorda, Gabriele Forlani, Roberta Manti, Arianna Mazzotti, Salvatore De Cosmo, Maria Chiara Rossi, Antonio Nicolucci, Paolo Di Bartolo, Antonio Ceriello, Pietro Guida, Barbara Tartaglino, Giuseppina Russo
AIMS: The prevalence and progression of hepatic fibrosis and its correlated factors in type 2 diabetes (T2DM) are poorly known. We aimed to define the percentage of T2DM patients who progress to fibrosis and the factors associated with disease progression. METHODS: Data from the electronic health records of 1527 patients with diagnosed T2DM and nonalcoholic fatty liver disease (NAFLD), as diagnosed by the Fatty Liver Index, were extracted from the AMD Annals database, which collects data from the Italian network of diabetes clinics...
October 30, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29065698/annals-express-dysregulation-of-serum-mir-574-3p-and-its-clinical-significance-in-hepatocellular-carcinoma
#2
Xianjuan Shen, Yajing Xue, Hui Cong, Xudong Wang, Shaoqing Ju
OBJECTIVES: To explore microRNA-574-3p (miR-574-3p) expression in serum of patients with hepatocellular carcinoma (HCC), and investigate correlations between serum miR-574-3p expression and the development and prognosis of HCC. Designandmethods: Serum samples were collected from 70 patients with primary HCC, 40 patients with cirrhosis and 45 healthy controls. Serum miR-574-3p expression levels were detected by real-time quantitative PCR. The linearity, specificity and reproducibility were evaluated...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29058958/annals-express-biomarkers-in-mesothelioma
#3
David T Arnold, Nick Maskell
Mesothelioma is an aggressive cancer of pleural and peritoneal cells that is difficult to diagnose and monitor. Numerous studies have attempted to identify a blood- or pleural fluid-based biomarker that could be used in the diagnostic pathway. More recently there has been interest in the ability of serum/plasma biomarkers to monitor mesothelioma, given development of newer treatments, and limitations of radiological assessment. The majority of research has focused on soluble mesothelin (SM), a soluble glycoprotein expressed by mesothelial cells...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29027807/biochemistry-of-the-menopause
#4
John W Honour
The life of a human female is characterized from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the perimenopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28990817/annals-express-a-combined-liquid-chromatography-tandem-mass-spectrometry-assay-for-the-quantification-of-urinary-oxalate-and-citrate-for-diagnosis-and-management-of-nephrolithiasis
#5
David John Marshall, Joanne Elaine Adaway, Brian G Keevil
Background 24 hour urine citrate and oxalate analysis is important in the screening and monitoring of patients with nephrolithiasis. To streamline the analytical process it was decided to combine oxalate and citrate and analyse them simultaneously in the same assay. Objective A highly sensitive and specific assay for analysis of urine citrate and oxalate was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) with a simple weak anion exchange solid phase extraction (WAX SPE) clean up procedure...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28939716/resistant-hypertension-time-updated-blood-pressure-values-and-renal-outcome-in-type-2-diabetes-mellitus
#6
Francesca Viazzi, Pamela Piscitelli, Antonio Ceriello, Paola Fioretto, Carlo Giorda, Pietro Guida, Giuseppina Russo, Salvatore De Cosmo, Roberto Pontremoli
BACKGROUND: Apparent treatment resistant hypertension (aTRH) is highly prevalent in patients with type 2 diabetes mellitus (T2D) and entails worse cardiovascular prognosis. The impact of aTRH and long-term achievement of recommended blood pressure (BP) values on renal outcome remains largely unknown. We assessed the role of aTRH and BP on the development of chronic kidney disease in patients with T2D and hypertension in real-life clinical practice. METHODS AND RESULTS: Clinical records from a total of 29 923 patients with T2D and hypertension, with normal baseline estimated glomerular filtration rate and regular visits during a 4-year follow-up, were retrieved and analyzed...
September 22, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28930781/is-article-methodological-quality-associated-with-conflicts-of-interest-an-analysis-of-the-plastic-surgery-literature
#7
Brian H Cho, Joseph Lopez, Jessica Means, Sandra Lopez, Jacqueline Milton, Anthony P Tufaro, James W May, Amir H Dorafshar
PURPOSE: Conflicts of interest (COI) are an emerging area of discussion within the field of plastic surgery. Recently, several reports have found that research studies that disclose COI are associated with publication of positive outcomes. We hypothesize that this association is driven by higher-quality studies receiving industry funding. This study aimed to investigate the association between industry support and study methodological quality. METHODS: We reviewed all entries in Plastic and Reconstructive Surgery, Annals of Plastic Surgery, and Journal of Plastic, Reconstructive, and Aesthetic Surgery within a 1-year period encompassing 2013...
December 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28920468/annals-express-macrocomplexes-and-discordant-high-sensitivity-cardiac-troponin-concentrations
#8
Pete Kavsak, Chantele Roy, Paul Malinowski, Ching-Tong Mark, Terry Scott, Lorna Clark, Shana Lamers, Craig Ainsworth
BACKGROUND: Analytical comparisons between different high-sensitivity cardiac troponin (hs-cTn) assays are important for reassurance of results performed with different methodologies and to identify potential interferences or confounders to result interpretation. Our objective in the present study was to compare Beckman Coulter's latest hs-cTnI assay to Abbott's hs-cTnI assay and to assess agreement between results. METHODS: Two hundred EDTA plasma samples that had clinically reported hs-cTnI results from the Abbott ARCHITECTi2000 that spanned the analytical range were stored (median=4h), re-centrifuged and retested for hs-cTnI on the Abbott ARCHITECTi1000 and Beckman Coulter Access2 analyzers...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28853295/annals-express-influence-of-cytochrome-p450-genotype-on-the-plasma-disposition-of-prochlorperazine-metabolites-and-their-relationships-with-clinical-responses-in-cancer-patients
#9
Masaki Tashiro, Takafumi Naito, Yoshiyuki Kagawa, Junichi Kawakami
BACKGROUND: Oral prochlorperazine, a dopamine D2 receptor antagonist, is largely metabolized to sulfoxide, 7-hydroxylate, and N-desmethylate by cytochrome P450s (CYPs). This study evaluated the influence of CYP genotype on the plasma dispositions of prochlorperazine and its metabolites and their relationships with antiemetic efficacy and prolactin elevation in cancer patients. METHODS: Forty-eight cancer patients treated with oral prochlorperazine were enrolled...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28814103/annals-express-associations-between-glycaemic-control-and-activation-of-the-renin-angiotensin-aldosterone-system-in-participants-with-type-2-diabetes-mellitus-and-hypertension
#10
Tomas Patrick Griffin, Deirdre Wall, Gerard A Browne, Michael C Dennedy, Paula O'Shea
INTRODUCTION: Hyperglycaemia increases succinate levels and succinate receptor (GPR91) activation in the kidney resulting in renin release. The aim of our study was to determine if there is an association between glycaemic control as evidenced by glycated haemoglobin (HbA1c) values and activation of the renin-angiotensin-aldosterone-system in patients with type 2 diabetes mellitus (T2DM) and hypertension. METHODS: A cross-sectional study was conducted at Galway University Hospitals between December 2014 and March 2015...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28790497/do-stories-deserve-a-place-in-medical-journals
#11
Christine Laine
Given the high costs of producing a medical journal, the need to publish clinically relevant information, and the fact that many journals can publish only a small fraction of the many scientific papers they consider, it seems reasonable to wonder whether stories deserve a place in a scholarly medical journal. Using examples from Annals of Internal Medicine, this commentary discusses the important role stories can serve in scholarly medical journals.
2017: Transactions of the American Clinical and Climatological Association
https://www.readbyqxmd.com/read/28758086/research-designs-and-statistical-methods-trends-in-the-annals-of-rehabilitation-medicine
#12
Jinmo Kim, Seihee Yoon, Jung Joong Kang, Kyunghwa Han, Jong Moon Kim, Shin Kyoung Kim
OBJECTIVE: To investigate trends of the research designs and statistical methods in the Annals of Rehabilitation Medicine (ARM) published from 2005 to 2015 through a comparison of articles with the Archives of Physical Medicine and Rehabilitation (APMR). METHODS: The authors reviewed all articles published in ARM and APMR for the years 2005 and 2015 in order to determine their research designs as well as their statistical methods used in each article. RESULTS: In ARM, randomized controlled trials increased from 4...
June 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28726484/experience-with-newer-central-nervous-system-autoantibodies
#13
A R Karim, S Jacob
In the last decade, a large number of neuronal cell-surface antibodies have been described which are responsible for a range of neuroimmunological central nervous system disorders. Unlike the paraneoplastic antibodies which target intracellular antigens, these antibodies appear to be pathogenic and hence identification and prompt treatment can make a substantial impact on clinical outcomes of these patients. We review the common antibodies against the ionotropic glutamate receptors (NMDAR, AMPAR), metabotropic glutamate receptors (mGluR1 and mGluR5), voltage-gated potassium channel-complex proteins (LGI1, CASPR2), and other antibodies targeted against glycine receptor, glutamic acid decarboxylase, gamma-amino butyric acid B, dopamine-2-receptor and dipeptidyl-peptidase-like protein 6...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28720618/interpretation-of-cis-in-clinical-trials-with-non-significant-results-systematic-review-and-recommendations
#14
Jennifer S Gewandter, Michael P McDermott, Rachel A Kitt, Jenna Chaudari, James G Koch, Scott R Evans, Robert A Gross, John D Markman, Dennis C Turk, Robert H Dworkin
OBJECTIVES: Interpretation of CIs in randomised clinical trials (RCTs) with treatment effects that are not statistically significant can distinguish between results that are 'negative' (the data are not consistent with a clinically meaningful treatment effect) or 'inconclusive' (the data remain consistent with the possibility of a clinically meaningful treatment effect). This interpretation is important to ensure that potentially beneficial treatments are not prematurely abandoned in future research or clinical practice based on invalid conclusions...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28647720/thinker-soldier-scribe-cross-sectional-study-of-researchers-roles-and-author-order-in-the-annals-of-internal-medicine
#15
Thomas V Perneger, Antoine Poncet, Marc Carpentier, Thomas Agoritsas, Christophe Combescure, Angèle Gayet-Ageron
OBJECTIVE: How researchers' contributions relate to author order on the byline remains unclear. We sought to identify researchers' contributions associated with author order, and to explore the existence of author profiles. DESIGN: Observational study. SETTING: Published record. PARTICIPANTS: 1139 authors of 119 research articles published in 2015 in the Annals of Internal Medicine. PRIMARY OUTCOMES: Presence or absence of 10 contributions, reported by each author, published in the journal...
June 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28625821/the-use-of-study-registration-and-protocols-in-plastic-surgery-research-a-systematic-review
#16
REVIEW
Thomas Edward Pidgeon, Christopher Limb, Riaz A Agha, Katharine Whitehurst, Charmilie Chandrakumar, Georgina Wellstead, Alexander J Fowler, Dennis P Orgill
BACKGROUND: In 2013, the Declaration of Helsinki changed to mandate that all research studies involving human subjects, rather than just clinical trials alone, must have a protocol registered in a publicly accessible database prior to the enrolment of the first patient. The objective of this work was to assess the number of research studies involving human participants published in leading journals of plastic surgery that had either published a protocol or registered a protocol with a publicly accessible database...
June 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28607417/predictors-of-chronic-kidney-disease-in-type-1-diabetes-a-longitudinal-study-from-the-amd-annals-initiative
#17
Pamela Piscitelli, Francesca Viazzi, Paola Fioretto, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina Russo, Pietro Guida, Roberto Pontremoli, Salvatore De De Cosmo
We evaluated 2,656 patients with type 1 diabetes mellitus and preserved renal function from the database of the Italian Association of Clinical Diabetologists network to identify clinical predictors for the development of chronic kidney disease. We measured estimated glomerular filtration rate (eGFR), urinary albumin excretion, HbA1c, lipids, blood pressure. Over a 5-year period 4.3% (n = 115) developed reduced eGFR (<60 ml/min/1.73 m(2)), 18.0% (n = 477) albuminuria, and 21.0% (n = 559) either one of the renal endpoints (CKD)...
June 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28586906/irritable-bowel-syndrome
#18
REVIEW
Shahnaz Sultan, Ashish Malhotra
This issue provides a clinical overview of irritable bowel syndrome, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
June 6, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28534382/meta-meta-analysis-a-paradigm-in-the-case-of-surgical-publications
#19
Georgios C Sotiropoulos, Nikolaos Machairas, Stylianos Kykalos, Paraskevas Stamopoulos, Anastasia Prodromidou, Athanasios Katsargyris
PURPOSE: Meta-analyses are considered to provide level I-II evidence. Based on this premise, several statements have been developed to standardize guidelines and optimize results. The purpose of this study was to investigate the quality of the information delivered by meta-analyses. METHODS: Meta-analyses published in Annals of Surgery during an 11-year period were reviewed whereas individual publications of each meta-analysis were assessed. An Excel database encompassing 29 parameters was constructed based on the Quality of Reporting of Meta-analyses (QUOROM) statement...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28493948/gender-bias-in-clinical-case-reports-a-cross-sectional-study-of-the-big-five-medical-journals
#20
Pascale Allotey, Caitlin Allotey-Reidpath, Daniel D Reidpath
BACKGROUND: Gender bias in medical journals can affect the science and the benefit to patients. It has never been investigated in clinical case reports. The oversight is important because of the role clinical case reports play in hypothesis generation and medical education. We investigated contemporary gender bias in case reports for the highest ranked journals in general and internal medicine. METHODS: PubMed case reports data from 2011 to 2016 were extracted for the Annals of Internal Medicine, British Medical Journal, the Journal of the American Medical Association, The Lancet, and New England Journal of Medicine...
2017: PloS One
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