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https://www.readbyqxmd.com/read/27919097/preoperative-evaluation-for-noncardiac-surgery
#1
Steven L Cohn
This issue provides a clinical overview of preoperative evaluation for noncardiac surgery, focusing on risk factors, elements of evaluation, medication management, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
December 6, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27884661/association-of-kidney-disease-measures-with-risk-of-renal-function-worsening-in-patients-with-hypertension-and-type-2-diabetes
#2
Francesca Viazzi, Pamela Piscitelli, Carlo Giorda, Antonio Ceriello, Stefano Genovese, Giuseppina T Russo, Paola Fioretto, Pietro Guida, Salvatore De Cosmo, Roberto Pontremoli
AIMS: To assess the role of kidney disease measures on the development of chronic kidney disease (CKD) in patients with type 2 diabetes (T2D) and hypertension (HT). METHODS: Clinical records from a total of 17,160 patients with T2D and HT, a baseline estimated glomerular filtration rate (eGFR) values ≥60mL/min/1.73m(2), evaluation for albuminuria and regular visits during a four-year follow-up were retrieved and analyzed. The incidence of eGFR <60mL/min/1.73m(2) and/or a reduction >30% from baseline was evaluated...
October 29, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27855102/non-inferiority-trials-are-they-inferior-a-systematic-review-of-reporting-in-major-medical-journals
#3
Sunita Rehal, Tim P Morris, Katherine Fielding, James R Carpenter, Patrick P J Phillips
OBJECTIVE: To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. DESIGN: Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medicine, Annals of Internal Medicine, BMJ, JAMA, Lancet and New England Journal of Medicine)...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27810997/annals-express-clinical-significance-of-gcf-sil-6r-and-calprotectin-to-evaluate-the-periodontal-inflammation
#4
Yukari Kajiura, Jung Hwan Lew, Takahisa Ikuta, Yasufumi Nishikawa, Jun-Ichi Kido, Toshihiko Nagata, Koji Naruishi
BACKGROUND: Periodontitis is a inflammatory disease. The aim of this study was to investigate whether soluble form of interleukin-6 receptor (sIL-6R) and calprotectin levels in gingival crevicular fluid (GCF) are useful bio-marker to evaluate the periodontitis. METHODS: At first, cross-sectional study was performed. A total of 34 periodontitis patients were enrolled and the GCF samples were collected from healthy and inflamed sites of periodontal pockets in each patient...
November 3, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27810996/annals-express-stability-of-ionized-calcium-measurements-at-concentrations-less-than-0-3-mmol-l-by-point-of-care-blood-gas-instruments-application-for-post-filter-calcium-quality-control-in-patients-with-citrate-anticoagulation-during-extracorporeal-circulation
#5
Maria Averina, Raymond Jakobsen
: BackgroundMeasurements of ionized calcium (Ca(2)(+)) at concentrations less than 0.3 mmol/L are required for post-filter control in patients that receive extracorporeal circulation with sodium citrate anticoagulation. This study evaluates the stability of the Ca(2)(+) measurements at such concentrations. MethodsThe stability of the Ca(2)(+) measurements was tested by measuring daily the external standard Qualicheck concentration 3 s7950, Radiometer (0.22-0.25 mmol/L) by blood gas instruments ABL800 and ABL90, Radiometer...
November 3, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27802475/giant-cell-arteritis
#6
Gary S Hoffman
This issue provides a clinical overview of giant cell arteritis, focusing on diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
November 1, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27799298/annals-express-uptake-of-recommended-common-reference-intervals-for-chemical-pathology-in-australia
#7
Graham Jones, Sabrina Koetsier
BackgroundReference intervals are a vital part of reporting numerical pathology results. It is known however that variation in reference intervals between laboratories is common, even when analytical methods support common reference intervals. In response to this in Australia, the Australasian Association of Clinical Biochemists (AACB) together with the Royal College of Pathologists of Australasia (RCPA) published in 2014 a set of recommended common reference intervals for twelve common serum analytes (sodium, potassium, chloride, bicarbonate, creatinine male, creatinine female, calcium, calcium adjusted for albumin, phosphate, magnesium, lactate dehydrogenase, alkaline phosphatase, total protein)...
October 31, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27755483/predictors-of-chronic-kidney-disease-in-type-2-diabetes-a-longitudinal-study-from-the-amd-annals-initiative
#8
Salvatore De Cosmo, Francesca Viazzi, Antonio Pacilli, Carlo Giorda, Antonio Ceriello, Sandro Gentile, Giuseppina Russo, Maria C Rossi, Antonio Nicolucci, Pietro Guida, Roberto Pontremoli
: The identification of clinical predictors for the development of chronic kidney disease is a critical issue in the management of patients with type 2 diabetes mellitus.We evaluated 27,029 patients with type 2 diabetes mellitus and estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m and normoalbuminuria from the database of the Italian Association of Clinical Diabetologists network. Primary outcomes were eGFR <60 mL/min/1.73 m and normoalbuminuria; albuminuria and eGFR ≥60 mL/min/1...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27742851/annals-express-the-role-of-calculated-non-caeruloplasmin-bound-copper-in-wilson-s-disease
#9
Andrew Duncan, Calum Yacoubian, Robert Beetham, Anthony Catchpole, David Bullock
BACKGROUND: US and European guidelines suggest the use of calculated non-caeruloplasmin bound copper (free copper index) for the diagnosis and management of Wilson's Disease. However, there is concern that the required analytical measurements of caeruloplasmin and copper may not be sufficiently robust at the concentrations usually found. METHODS: Aliquots of six plasma specimens were sent to laboratories participating in the UK National External Quality Assessment Scheme for copper and caeruloplasmin...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27742848/annals-express-vitamin-d-binding-protein-as-it-is-understood-in-2016-is-it-a-critical-key-with-which-to-help-to-solve-the-calcitriol-conundrum
#10
Richard X Davey
BACKGROUND: The misnamed 'vitamin' D is actually the hormone calcitriol (1,25 dihydroxyhydroxyvitamin D). It has a central regulatory role in calcium metabolism, and more widely in the immune system. The prohormone calcifediol (25 hydroxyvitamin D) is more easily measured in the laboratory and is the analyte used in reference interval formulation. Being highly lipid soluble, both calcifediol and calcitriol travel in the bloodstream on carriage proteins, principally on vitamin D binding protein, DBP...
October 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27716793/outcomes-definitions-and-statistical-tests-in-oncology-studies-a-systematic-review-of-the-reporting-consistency
#11
Romain Rivoirard, Vianney Duplay, Mathieu Oriol, Fabien Tinquaut, Franck Chauvin, Nicolas Magne, Aurelie Bourmaud
BACKGROUND: Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. METHODS: From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC)...
2016: PloS One
https://www.readbyqxmd.com/read/27705887/annals-express-chitotriosidase-enzyme-activity-is-this-a-possible-chronic-inflammation-marker-in-children-with-common-variable-immunodeficiency-and-early-atherosclerosis
#12
Elif Azarsız, Neslihan Karaca, Erturk Levent, Necil Kutukculer, Eser Sozmen
BACKGROUND: Common variable immunodeficiency (CVID) is a rare clinically symptomatic primary immunodeficiency disorder which manifests a wide variability of symptoms, complications. Atherosclerosis in CVID patients have not been investigated yet contrary to other severe clinical complications. We aimed to investigate the chitotriosidase enzyme's role as an inflammation and atherosclerosis marker in pediatric CVID patients. METHODS: CVID patients (n =24) and healthy controls (n = 23) evaluated for chitotriosidase activity with other inflammation markers (hsCRP, myeloperoxidase, serum amyloid A, ferritin), lipid profile and echocardiographic findings (carotid artery intima media thickness - cIMT, brachial artery flow-mediated vazodilatation - FMD%)...
October 4, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27699401/depression
#13
Robert M McCarron, Erik R Vanderlip, Jeffrey Rado
This issue provides a clinical overview of depression, focusing on screening, diagnosis, treatment, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers...
October 4, 2016: Annals of Internal Medicine
https://www.readbyqxmd.com/read/27687083/annals-express-evaluation-of-reduced-centrifugation-time-and-higher-centrifugal-force-on-chemistry-and-immunochemistry-analytes-in-plasma-and-serum
#14
Mette Fogh Møller, Tove Rask Søndergaard, Helle Tanderup Kristensen, Anna-Marie Bloch Münster
BACKGROUND: Centrifugation of blood samples is an essential pre-analytical step in the clinical biochemistry laboratory. Centrifugation settings are often altered to optimize sample flow and turnaround time. Few studies have addressed the effect of altering centrifugation settings on analytical quality, and almost all studies have been done using collection tubes with gel separator. METHODS: In this study we compared a centrifugation time of 5 min at 3000 × g to a standard protocol of 10 min at 2200 × g...
September 28, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27687080/annals-express-natural-selection-the-evolution-of-diagnostic-criteria-for-gestational-diabetes
#15
Claire L Meek
Gestational diabetes (GDM) is a common pregnancy disorder which is generally managed with diet, exercise, metformin or insulin treatment and which usually resolves after delivery of the infant. Identifying and treating GDM improves maternal and fetal outcomes, and allows for health promotion to reduce the mother's risk of type 2 diabetes in later life. However, there remains considerable controversy about the optimal method of identification and diagnosis of women with GDM. The NICE-2015 diagnostic criteria (75g oral glucose tolerance test (OGTT) 0 hr ⩾5...
September 28, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27652107/the-100-most-influential-publications-in-paracetamol-poisoning-treatment-a-bibliometric-analysis-of-human-studies
#16
Sa'ed H Zyoud, W Stephen Waring, Samah W Al-Jabi, Waleed M Sweileh, Rahmat Awang
BACKGROUND: Analysis of the most influential publications within paracetamol poisoning treatment can be helpful in recognizing main and novel treatment issues within the field of toxicology. The current study was performed to recognize and describe the most highly cited articles related to paracetamol poisoning treatment. METHODS: The 100 most highly cited articles in paracetamol poisoning treatment were identified from the Scopus database in November 2015. All eligible articles were read for basic information, including total number of citations, average citations per year, authors' names, journal name, impact factors, document types and countries of authors of publications...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27632024/additive-manufacturing-of-biomaterials-tissues-and-organs
#17
Amir A Zadpoor, Jos Malda
The introduction of additive manufacturing (AM), often referred to as three-dimensional (3D) printing, has initiated what some believe to be a manufacturing revolution, and has expedited the development of the field of biofabrication. Moreover, recent advances in AM have facilitated further development of patient-specific healthcare solutions. Customization of many healthcare products and services, such as implants, drug delivery devices, medical instruments, prosthetics, and in vitro models, would have been extremely challenging-if not impossible-without AM technologies...
September 8, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27629911/annals-express-analysis-of-urinary-human-chorionic-gonadotrophin-levels-in-normal-and-failing-pregnancies-using-longitudinal-cox-proportional-hazards-and-two-stage-modelling
#18
Lorrae Marriott, Michael Zinaman, Keith R Abrams, Michael J Crowther, Sarah Johnson
BACKGROUND: Human chorionic gonadotrophin (hCG) is a marker of early pregnancy. This study sought to determine the possibility of being able to distinguish between healthy and failing pregnancies by utilising patient-associated risk factors and daily urinary hCG levels. METHODS: Data were from a study that collected daily early morning urine samples from women trying to conceive (n=1,505); 250 of whom became pregnant. Data from 129 women who became pregnant (including 44 miscarriages) were included in these analyses...
September 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27629910/annals-express-stabilization-of-circulating-thyroglobulin-mrna-transcripts-in-patients-treated-for-differentiated-thyroid-carcinoma
#19
Søren Feddersen, Lars Bastholt, Susanne Møller Pedersen
BACKGROUND: The clinical utility of serum thyroglobulin (TG) in the follow-up of patients with differentiated thyroid carcinoma (DTC) may be compromised by the presence of endogenous anti-thyroglobulin antibodies (TGAb). To prevent interference by TGAb several groups have developed real-time PCR (RT-PCR) based assays for quantification of blood TG mRNA levels. For accurate quantification of TG mRNA in blood preanalytical factors must be recognized and controlled. In this study we evaluate the effect of different blood RNA stabilizing systems - the Tempus(T) (M) Blood RNA system and the PAXgene(T) (M) Blood RNA system - and storage time on RNA yield and quality, and TG mRNA stability...
September 13, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27629909/annals-express-identification-of-hb-new-york-by-hba1c-measurement-using-the-sebia-capillarys-2-flex-piercing-system
#20
Yan Chao, Zemin Wan, Xiaobin Wu, Feng Qiu, Xinzhong Wu, Yunxiu Wang, Peifeng Ke, Jianhua Xu, Junhua Zhuang, Xianzhang Huang
Haemoglobinopathies may interfere with the hemoglobin A1 c (HbA1 c) measurement, leading to incorrect diagnosis and inappropriate treatment. It is essential that HbA1 c assays are capable of identifying haemoglobinopathies. We report two cases of haemoglobin New York (HbNY) discovered through HbA1 c analysis using capillary electrophoresis (Capillarys 2 Flex Piercing [C2FP], Sebia). We used these samples to evaluate the ability of three other HbA1 c assays to identify this variant: ion-exchange high performance liquid chromatography (HPLC; Variant II Turbo [VII-T], Bio-Rad); boronate affinity HPLC (Ultra(2), Trinity Biotech); and immunoassay (cobas c501 Tina-quant Generation 3, Roche Diagnostics)...
September 13, 2016: Annals of Clinical Biochemistry
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