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Exercise ECG

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https://www.readbyqxmd.com/read/28219898/sk4-k-channels-are-therapeutic-targets-for-the-treatment-of-cardiac-arrhythmias
#1
Shiraz Haron-Khun, David Weisbrod, Hanna Bueno, Dor Yadin, Joachim Behar, Asher Peretz, Ofer Binah, Edith Hochhauser, Michael Eldar, Yael Yaniv, Michael Arad, Bernard Attali
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-provoked ventricular arrhythmia, which also manifests sinoatrial node (SAN) dysfunction. We recently showed that SK4 calcium-activated potassium channels are important for automaticity of cardiomyocytes derived from human embryonic stem cells. Here SK4 channels were identified in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from healthy and CPVT2 patients bearing a mutation in calsequestrin 2 (CASQ2-D307H) and in SAN cells from WT and CASQ2-D307H knock-in (KI) mice...
February 20, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28212075/towards-photoplethysmography-based-estimation-of-instantaneous-heart-rate-during-physical-activity
#2
Delaram Jarchi, Alex Casson
OBJECTIVE: Recently numerous methods have been proposed for estimating average heart rate using photoplethysmography (PPG) during physical activity, overcoming the significant interference that motion causes in PPG traces. We propose a new algorithm framework for extracting instantaneous heart rate from wearable PPG and ECG signals to provide an estimate of heart rate variability during exercise. METHODS: For ECG signals we propose a new spectral masking approach which modifies a particle filter tracking algorithm, and for PPG signals constrains the instantaneous frequency obtained from the Hilbert transform to a region of interest around a candidate heart rate measure...
February 13, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28179611/asymptomatic-cocaine-abuse%C3%A3-myocardial-tissue-characterization-using-cardiac-biomarkers-and-cardiovascular-magnetic-resonance-imaging
#3
Ulf K Radunski, Ulrike Fuger, Sebastian Bohnen, Gunnar K Lund, Christian Stehning, Tanja Zeller, Enver Tahir, Maxim Avanesov, Gerhard Adam, Stefan Blankenberg, Jens Reimer, Kai Muellerleile
BACKGROUND: Use of cocaine is widespread and associated with several cardiovascular diseases. Recent CMR studies indicate frequent myocardial scar/fibrosis in asymptomatic cocaine abusers (CA).Methods and Results:This study used a combination of advanced CMR tissue characterization techniques, including late gadolinium enhancement (LGE) for focal, and extracellular volume (ECV) imaging for diffuse myocardial injury/fibrosis, with circulating biomarkers for a comprehensive characterization of myocardial injury...
February 7, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28144449/intermediate-risk-chronic-stable-angina-neutrophil-lymphocyte-ratio-and-fibrinogen-levels-improved-predicting-angiographically-detected-coronary-artery-disease
#4
Habib Haybar, Ahmad Ahmadzadeh, Ahmadreza Assareh, Nader Afshari, Mohammadreza Bozorgmanesh, Mahdis Vakili
BACKGROUND: Coronary heart disease (CHD) is the leading cause of death worldwide. Research indicates that coronary atherosclerosis is the most frequent cause of CHD. Evidence is scarce concerning the clinical efficacy of fibrinogen or neutrophil-lymphocyte ratio (NLR) measurement in risk-stratifying patients with chronic stable angina. OBJECTIVES: To examine the independent and incremental prognostic value of fibrinogen and neutrophil-lymphocyte ratio (NLR) for angiographically-detected coronary artery disease (CAD)...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28139138/the-value-of-predischarge-exercise-ecg-testing-in-chest-pain-patients-in-the-era-of-high-sensitivity-troponins
#5
Lina Ljung, Martin Sundqvist, Tomas Jernberg, Kai M Eggers, Gunnar Ljunggren, Mats Frick
BACKGROUND: The aim of this study was to examine the value of predischarge exercise electrocardiogram (ECG) testing of chest pain patients in whom acute myocardial infarction (MI) had been ruled out by means of high-sensitivity troponins, ECG and history. METHODS: All patients hospitalised for chest pain who underwent exercise ECG testing before discharge from the Department of Cardiology, Södersjukhuset, Stockholm, Sweden from January 2011 to June 2012 were included...
January 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28096758/effects-of-acute-ingestion-of-a-pre-workout-dietary-supplement-with-and-without-p-synephrine-on-resting-energy-expenditure-cognitive-function-and-exercise-performance
#6
Y Peter Jung, Conrad P Earnest, Majid Koozehchian, Elfego Galvan, Ryan Dalton, Dillon Walker, Christopher Rasmussen, Peter S Murano, Mike Greenwood, Richard B Kreider
BACKGROUND: The purpose of this study was to examine the effects of acute ingestion of a pre-workout dietary supplement (PWS) with and without p-synephrine (S) on perceptions of readiness to perform, cognitive function, exercise performance, and markers of safety. METHODS: In a randomized, double-blind, and counterbalanced manner; 25 healthy and recreationally active male and female participants ingested a flavored maltodextrin placebo (PLA), a PWS containing beta-alanine (3 g), creatine nitrate as a salt (2 g), arginine alpha-ketoglutarate (2 g), N-Acetyl-L-Tyrosine (300 mg), caffeine (284 mg), Mucuna pruiriens extract standardized for 15% L-Dopa (15 mg), Vitamin C as Ascorbic Acid (500 mg), niacin (60 mg), folate as folic acid (50 mg), and Vitamin B12 as Methylcobalamin (70 mg) with 2 g of maltodextrin and flavoring; or, the PWS with Citrus aurantium (PWS + S) extract standardized for 30% p-synephrine (20 mg)...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28095950/ct-coronary-angiography-vs-coronary-artery-calcium-scoring-for-the-occupational-assessment-of-military-aircrew
#7
Iain Parsons, Chris Pavitt, Rebecca Chamley, Jo d'Arcy, Ed Nicol
INTRODUCTION: To ensure flight safety military aircrew undergo regular clinical and occupational assessment. Coronary artery calcium scoring (CACS) has been established as an imaging modality to noninvasively assess coronary artery disease (CAD). CT coronary angiography (CTCA) potentially offers a more accurate assessment of CAD, but has not been formally assessed in military aircrew. This retrospective cohort study is designed to compare the theoretical differences in downstream investigations and occupational outcomes in aircrew with suspected CAD comparing CTCA with existing CACS pathways...
February 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28039126/are-olympic-athletes-free-from-cardiovascular-diseases-systematic-investigation-in-2352-participants-from-athens-2004-to-sochi-2014
#8
Antonio Pelliccia, Paolo Emilio Adami, Filippo Quattrini, Maria Rosaria Squeo, Stefano Caselli, Luisa Verdile, Viviana Maestrini, Fernando Di Paolo, Cataldo Pisicchio, Roberto Ciardo, Antonio Spataro
CONTEXT: Olympic athletes represent model of success in our society, by enduring strenuous conditioning programmes and achieving astonishing performances. They also raise scientific and clinical interest, with regard to medical care and prevalence of cardiovascular (CV) abnormalities. OBJECTIVE: Our aim was to assess the prevalence and type of CV abnormalities in this selected athlete's cohort. DESIGN, SETTING AND PARTICIPANTS: 2352 Olympic athletes, mean age 25±6, 64% men, competing in 31 summer or 15 winter sports, were examined with history, physical examination, 12-lead and exercise ECG and echocardiography...
February 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28034568/efficacy-and-safety-of-balloon-pulmonary-angioplasty-for-chronic-thromboembolic-pulmonary-hypertension-guided-by-cone-beam-computed-tomography-and-electrocardiogram-gated-area-detector-computed-tomography
#9
Takeshi Ogo, Tetsuya Fukuda, Akihiro Tsuji, Shigefumi Fukui, Jin Ueda, Yoshihiro Sanda, Yoshiaki Morita, Ryotaro Asano, Nao Konagai, Satoshi Yasuda
BACKGROUND: Chronic thromboembolic pulmonary hypertension (CTEPH) is a disease characterized by chronic obstructive thrombus and pulmonary hypertension. Balloon pulmonary angioplasty (BPA), an emerging alternative catheter-based treatment for inoperable patients with CTEPH, has not yet been standardised, especially for lesion assessment in distal pulmonary arteries. Recent advancement in computed tomography enables distal CTEPH lesions to be visualized. METHODS: We retrospectively studied 80 consecutive patients with inoperable CTEPH who received BPA guided by cone-beam computed tomography (CT) (CBCT) or electrocardiogram (ECG)-gated area detector CT (ADCT) for target lesion assessment...
December 21, 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/28034442/electrocardiographic-changes-induced-by-endurance-training-and-pubertal-development-in-male-children
#10
Flavio D'Ascenzi, Marco Solari, Francesca Anselmi, Francesca Valentini, Riccardo Barbati, Paola Palmitesta, Marta Focardi, Marco Bonifazi, Sergio Mondillo
Training-induced electrocardiographic changes are common in adult athletes. However, a few data are available on electrocardiogram (ECG) in preadolescent athletes and little is known about the potential changes induced by training on 12-lead electrocardiogram (ECG) at rest. Twelve-lead ECGs at rest and complete echocardiographic examinations were performed in 94 children (57 endurance athletes, 37 sedentary controls; mean age 10.8 ± 0.2 and 10.2 ± 0.2 years, respectively) at baseline and after 5 months of growth and training in athletes and of natural growth in controls...
December 3, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28027073/value-of-the-coronary-artery-disease-consortium-rule-in-patients-with-acute-chest-pain-and-negative-troponins-referred-for-exercise-stress-testing
#11
Alberto Bouzas-Mosquera, Jesús Peteiro, Francisco J Broullón, Ramón Calviño-Santos, Víctor X Mosquera, Dolores Martínez, Juan C Yáñez, Nemesio Álvarez-García, José M Vázquez-Rodríguez
OBJECTIVE: To assess the value of the pretest probability (PTP) of coronary artery disease (CAD) for predicting stress testing results and coronary events in patients with acute chest pain and negative troponins. PATIENTS AND METHODS: A total of 3527 patients without a history of CAD referred to our chest pain unit with suspected acute coronary syndromes, nondiagnostic ECGs, and negative troponin levels underwent exercise stress testing. PTP was estimated with the CAD consortium prediction rule, and was categorized as low (<15%), low-intermediate (15-65%), intermediate-high (66-85%), and high (>85%)...
December 23, 2016: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/27996996/-ecg-for-non-competitive-sports-in-childhood-strengths-and-disputes
#12
Elena Poggi, Alessandro Giannattasio, Sara Bolloli, Andrea Beccaria, Paola Mezzano, Paola Rocca, Cecilia Del Vecchio
BACKGROUND: Sport is very important for health promotion and conservation. Active lifestyle and regular exercise reduce cardiovascular disease incidence. The Italian Ministry of Health issued the Law Decree no. 243 (10/18/2014) concerning "guidelines for certification about non-competitive sports" to promote safety in sports. This regulation defines the activities for which a certificate is required, the professional actors involved and the clinical exams to be performed according to the patient's health status...
November 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/27910284/resting-heart-rate-is-an-independent-predictor-of-death-in-patients-with-colorectal-pancreatic-and-non-small-cell-lung-cancer-results-of-a-prospective-cardiovascular-long-term-study
#13
Markus S Anker, Nicole Ebner, Bert Hildebrandt, Jochen Springer, Marianne Sinn, Hanno Riess, Stefan D Anker, Ulf Landmesser, Wilhelm Haverkamp, Stephan von Haehling
AIMS: Patients with advanced cancer have been shown to suffer from abnormal cardiac function and impaired exercise capacity that may contribute to their impaired quality of life. As tachycardia is considered as a sign of potential early cardiac damage, we sought to determine whether resting heart rate and other ECG-derived variables have prognostic value. METHODS AND RESULTS: From 2005 to 2010, we enrolled 145 patients with histologically confirmed cancer (36 colorectal, 72 pancreatic, and 37 non-small cell lung cancer patients) and 59 healthy controls...
December 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27899826/an-elective-course-in-cardiovascular-electrophysiology-for-pharmacy-learners
#14
Diptiman D Bose
Objective. To implement an integrated, comprehensive, and learner-centered elective course focused at exposing learners to the interpretation of electrocardiograms and highlighting the mechanisms underlining the abnormal electrophysiological events. Design. Learners were presented with foundational information on the mechanisms underlying electrophysiological changes associated with the development of arrhythmias. They then discussed the interpretation of electrocardiogram (ECG) recordings and diagnosis of cardiovascular events...
October 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/27896702/safety-of-regadenoson-stress-testing-in-patients-with-pulmonary-hypertension
#15
Victor M Moles, Thomas Cascino, Ashraf Saleh, Krasimira Mikhova, John J Lazarus, Michael Ghannam, Hong J Yun, Matthew Konerman, Richard L Weinberg, Edward P Ficaro, James R Corbett, Vallerie V McLaughlin, Venkatesh L Murthy
OBJECTIVES: We sought to determine the safety of regadenoson stress testing in patients with PH. BACKGROUND: PH is increasingly recognized at more advanced ages. As many as one-third of patients with PH have coronary artery disease. Because of their physical limitations, patients with PH are unable to adequately exercise. Regadenoson can potentially have an adverse impact due to their tenuous hemodynamics. Current guidelines suggest performing a coronary angiography in patients with PH who have angina or multiple coronary risk factors...
November 28, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27894294/appropriate-threshold-levels-of-cardiac-beat-to-beat-variation-in-semi-automatic-analysis-of-equine-ecg-recordings
#16
Mette Flethøj, Jørgen K Kanters, Philip J Pedersen, Maria M Haugaard, Helena Carstensen, Lisbeth H Olsen, Rikke Buhl
BACKGROUND: Although premature beats are a matter of concern in horses, the interpretation of equine ECG recordings is complicated by a lack of standardized analysis criteria and a limited knowledge of the normal beat-to-beat variation of equine cardiac rhythm. The purpose of this study was to determine the appropriate threshold levels of maximum acceptable deviation of RR intervals in equine ECG analysis, and to evaluate a novel two-step timing algorithm by quantifying the frequency of arrhythmias in a cohort of healthy adult endurance horses...
November 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27881424/temporal-reduction-in-chronotropic-index-predicts-risk-of-cardiovascular-death-among-healthy-middle-aged-men-a-28-year-follow-up-study
#17
Kristian Engeseth, Christian Hodnesdal, Irene Grundvold, Knut Liestøl, Knut Gjesdal, Sverre E Kjeldsen, Jan E Erikssen, Johan Bodegard, Per Torger Skretteberg
BACKGROUND: Chronotropic index is a standardized measure of heart rate (HR) increment during exercise that reflects the combined effects of age, resting HR, and physical fitness. Low chronotropic index has been reported to predict disease and death. We tested whether temporal change in chronotropic index over 7 years influenced risk of cardiovascular death through up to 28 years. METHODS AND RESULTS: Chronotropic index was calculated ([achieved maximal HR-resting HR]/[age-predicted maximal HR-resting HR]) after a symptom-limited bicycle ECG exercise test in 1420 healthy men at 2 examinations 7 years apart, in 1972 and 1979...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27875477/smartphone-based-arrhythmia-monitoring
#18
Paul Garabelli, Stavros Stavrakis, Sunny Po
The use of smartphones for arrhythmia monitoring is another leap for ECG utilization and arrhythmia detection - effectively taking the technology to any smartphone user. Smart wearable technology, while very common, is limited mostly to activity tracking and exercise motivation. Rhythm strip generating smartphone products (Kardia Mobile by AliveCor and ECG Check by Cardiac Designs) are more powerful at arrhythmia detection than wearable monitors. These products, which have been studied in a variety of situations, rely on an external device with metal sensors to create a rhythm strip, which is usually Lead I...
January 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27863351/abnormal-heart-rate-response-during-cardiopulmonary-exercise-testing-identifies-cardiac-dysfunction-in-symptomatic-patients-with-non-obstructive-coronary-artery-disease
#19
Sundeep Chaudhry, Naresh Kumar, Hushyar Behbahani, Akshay Bagai, Binoy K Singh, Nick Menasco, Gregory D Lewis, Laurence Sperling, Jonathan Myers
BACKGROUND: Symptomatic non-obstructive coronary artery disease is a growing clinical dilemma for which contemporary testing is proving to be of limited clinical utility. New methods are needed to identify cardiac dysfunction. METHODS AND RESULTS: This is a prospective observational cohort study conducted from December 2013 to August 2015 in two outpatient cardiology clinics (symptomatic cohort) and 24 outpatient practices throughout the US (healthy cohort) with centralized methodology and monitoring to compare heart-rate responses during cardiopulmonary exercise testing (CPET)...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27847560/left-ventricular-false-tendons-and-electrocardiogram-repolarization-abnormalities-in-healthy-young-subjects
#20
Zlatan Lazarevic, Emanuela Ciminelli, Federico Quaranta, Fabio Sperandii, Emanuele Guerra, Fabio Pigozzi, Paolo Borrione
AIM: To describe echocardiographically left ventricular false tendon characteristics and the correlation with ventricular repolarization abnormalities in young athletes. METHODS: Three hundred and sixteen healthy young athletes from different sport disciplines were evaluated from 2009 to 2011 during routine screening for agonistic sports eligibility. All subjects, as part of standard pre-participation screening medical evaluation, underwent a basal and post step test 12-lead electrocardiogram (ECG)...
October 26, 2016: World Journal of Cardiology
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