Zhendong Xu, Jichang Hu, Zhen Wei, Yu Lei, Henok Kessete Afewerky, Yang Gao, Lu Wan, Longfei Li, Ling Lei, Yi Liu, Fang Huang, Tong Yu, Jian-Zhi Wang, Hong-Lian Li, Rong Liu, Xiaochuan Wang
Senile plaque, composed of amyloid β protein (Aβ) aggregates, is a critical pathological feature in Alzheimer's disease (AD), leading to cognitive dysfunction. However, how Aβ aggregates exert age-dependent toxicity and temporal cognitive dysfunction in APP/PS1 mice remains incompletely understood. In this study, we investigated AD pathogenesis and dynamic alterations in lysosomal pathways within the hippocampus of age-gradient male mice using transcriptome sequencing, molecular biology assays, and histopathological analyses...
April 2024: MedComm