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https://www.readbyqxmd.com/read/29929064/the-depersonalized-brain-new-evidence-supporting-a-distinction-between-depersonalization-and-derealization-from-discrete-patterns-of-autonomic-suppression-observed-in-a-non-clinical-sample
#1
Hayley Dewe, Derrick G Watson, Klaus Kessler, Jason J Braithwaite
Depersonalization and Derealization are characterised by feelings of detachment from one's bodily self/surroundings and a general emotional numbness. We explored predisposition to trait-based experiences of depersonalization/derealization-type experiences and autonomic arousal toward simulated body-threats, which were delivered to the participant's own body (i.e. Self) and when observed being delivered to another individual (i.e. Other). Ninety participants took part in an "Implied Body-Threat Illusion" task (Dewe, Watson, & Braithwaite, 2016) and autonomic arousal was recorded via standardised skin conductance responses and finger temperature...
June 18, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29928438/the-first-thermic-treatment-predicts-following-chemoradiation-response-with-concurrent-thermal-therapy-for-the-treatment-of-rectal-cancer
#2
Hisanori Shoji, Masahiko Motegi, Kiyotaka Osawa, Takayuki Asao, Hiroyuki Kuwano, Takeo Takahashi, Kyoji Ogoshi
The present study aimed to evaluate whether the neoadjuvant chemoradiation response with concurrent thermal therapy for the treatment of rectal cancer can be predicted following the first thermic treatment. Eighty patients with primary rectal adenocarcinoma (≤12 cm from the anal verge) were included in this study. Fifty-four received surgery and pathological response was evaluated. Intensity-modulated radiotherapy was administered conventionally once daily 5 times/week. Neoadjuvant radiotherapy consisted of 50 Gy delivered to the planning target volume in 25 fractions...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29926290/rotating-flow-of-ag-cuo-h-2-o-hybrid-nanofluid-with-radiation-and-partial-slip-boundary-effects
#3
Tanzila Hayat, S Nadeem, A U Khan
The main object of the present paper is to examine and compare the improvement of flow and heat transfer characteristics between a rotating nanofluid and a newly discovered hybrid nanofluid in the presence of velocity slip and thermal slip. The influence of thermal radiation is also included in the present study. The system after applying the similarity transformations is solved numerically by using the bvp-4c scheme. Additionally, numerical calculations for the coefficient of skin friction and local Nusselt number are introduced and perused for germane parameters...
June 14, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29925660/acidic-ph-mediates-changes-in-antigenic-and-oligomeric-conformation-of-herpes-simplex-virus-gb-and-is-a-determinant-of-cell-specific-entry
#4
Darin J Weed, Stephen J Dollery, Tri Komala Sari, Anthony V Nicola
Herpes simplex virus (HSV) is an important human pathogen with a high worldwide seroprevalence. HSV enters epithelial cells, the primary site of infection, by a low pH pathway. HSV glycoprotein B (gB) undergoes low pH-induced conformational changes, which are thought to drive membrane fusion. When neutralized back to physiological pH, these changes become reversible. Here, HSV-infected cells were subjected to short pulses of radiolabeling followed by immunoprecipitation with a panel of gB monoclonal antibodies (MAbs) demonstrating that gB folds and oligomerizes rapidly and co-translationally in the endoplasmic reticulum...
June 20, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29924310/physiological-strain-in-french-vineyard-workers-wearing-protective-equipment-to-conduct-re-entry-tasks-in-humid-conditions
#5
Sonia Grimbuhler, Jean-François Viel
The proper use of personal protective equipment (PPE) plays an important role in reducing exposure to pesticides in vineyard farming activities, including re-entry tasks. However, discomfort from clothing systems may increase the physiological burden on workers. We compared the physiological burdens of vineyard workers wearing three different types of PPE during canopy management in field humid conditions while accounting for occupational, climatic, and geographical environments. The study was conducted in the Bordeaux vineyards of southern France during June 2012...
June 19, 2018: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29923371/laser-safety-in-fiber-optic-monitoring-of-spinal-cord-hemodynamics-a-preclinical-evaluation
#6
David R Busch, James Davis, Angela Kogler, Robert M Galler, Ashwin B Parthasarathy, Arjun G Yodh, Thomas F Floyd
The prevention and treatment of spinal cord injury are focused upon the maintenance of spinal cord blood flow, yet no technology exists to monitor spinal cord ischemia. We recently demonstrated continuous monitoring of spinal cord ischemia with diffuse correlation and optical spectroscopies using an optical probe. Prior to clinical translation of this technology, it is critically important to demonstrate the safety profile of spinal cord exposure to the required light. To our knowledge, this is the first report of in situ safety testing of such a monitor...
June 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29921228/laser-capture-microdissection-for-transcriptomic-profiles-in-human-skin-biopsies
#7
Silvia Santoro, Ignazio Diego Lopez, Raffaella Lombardi, Andrea Zauli, Ana Maria Osiceanu, Melissa Sorosina, Ferdinando Clarelli, Silvia Peroni, Daniele Cazzato, Margherita Marchi, Angelo Quattrini, Giancarlo Comi, Raffaele Adolfo Calogero, Giuseppe Lauria, Filippo Martinelli Boneschi
BACKGROUND: The acquisition of reliable tissue-specific RNA sequencing data from human skin biopsy represents a major advance in research. However, the complexity of the process of isolation of specific layers from fresh-frozen human specimen by laser capture microdissection, the abundant presence of skin nucleases and RNA instability remain relevant methodological challenges. We developed and optimized a protocol to extract RNA from layers of human skin biopsies and to provide satisfactory quality and amount of mRNA sequencing data...
June 19, 2018: BMC Molecular Biology
https://www.readbyqxmd.com/read/29920941/effects-of-a-warm-hand-bath-on-the-blood-flow-in-the-shoulder-skin-and-deep-body-temperature-autonomic-nervous-activity-and-subjective-comfort-in-healthy-women-an-experimental-cross-over-trial
#8
Yukiko Kudo, Makiko Sasaki, Yukiko Kikuchi, Reiko Sugiyama, Makiko Hasebe, Noriko Ishii
AIM: The present study was conducted in order to clarify the effects of a warm hand bath at 40°C for 10 min on the blood flow in the shoulder, skin and deep body temperature, autonomic nervous activity, and subjective comfort in healthy women. METHODS: The study's participants were 40 healthy adult women who were randomly assigned to either a structured hand bath first and no hand bath second (Group A) or to no hand bath first and a hand bath second (Group B). The blood flow in the shoulder, skin and deep body temperature, autonomic nervous activity, and subjective comfort then were recorded in all the participants...
June 19, 2018: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/29920117/survival-of-escherichia-coli-o157-h7-salmonella-spp-and-listeria-monocytogenes-on-fresh-and-sliced-green-and-golden-kiwifruits
#9
Jing Yuan, Luxin Wang
Kiwifruit (Actinidia deliciosa) is a high-acidity fruit, with two varieties available on the market. One is the green-fleshed, fuzzy, sweet but tangy-tasting kiwifruit, and the other is the yellow-fleshed variety called "golden" kiwifruit. While the whole kiwifruit is sold at room temperature at grocery stores, sliced kiwifruit is usually sold as a part of fruit salad in the refrigerated section. The survival of a five-strain Escherichia coli O157:H7 cocktail, a five-strain Salmonella cocktail, and a five-strain Listeria monocytogenes cocktail was evaluated on whole and sliced green and golden kiwifruit...
June 19, 2018: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/29916391/amyloodiniosis-in-cultured-dicentrarchus-labrax-parasitological-and-molecular-diagnosis-and-an-improved-treatment-protocol
#10
Mohamed Bessat, Amr Fadel
Amyloodinium ocellatum, the causative agent of amyloodiniosis (marine velvet, velvet disease), affects marine and brackish fish in various warm and temperate habitats. We recorded disease outbreaks with high morbidity and mortality rates in marine-cultured European seabass Dicentrarchus labrax fry at 2 locations in northwest Egypt. The sudden outbreak, high morbidity and mortality rates, and skin lesions with a velvety appearance in affected fish all indicated A. ocellatum infection. This was further confirmed by microscopic findings of the parasitic stage (trophonts) in skin and gill smears...
June 19, 2018: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29915774/a-case-report-of-hypohidrotic-ectodermal-dysplasia-a-mini-review-with-latest-updates
#11
Girish Gulab Meshram, Neeraj Kaur, Kanwaljeet Singh Hura
Ectodermal dysplasia (ED) is a rare hereditary disorder involving two or more of the ectodermal structures, which include the skin, hair, nails, teeth, and sweat glands. The two most common forms of the disease are hypohidrotic/anhidrotic ED and hidrotic ED. They are caused by the mutations of several genes. We present a case of a 9-year-old child with hypohidrotic ED, who presented with hypodontia, dyshidrosis, hypotrichosis, and raised body temperature. We treated the raised body temperature symptomatically with cooling techniques and antipyretics...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29914698/physiological-and-perceptual-responses-in-the-elderly-to-simulated-daily-living-activities-in-uk-summer-climatic-conditions
#12
K A M Waldock, M Hayes, P W Watt, N S Maxwell
OBJECTIVES: The elderly population is at an increasingly significant health risk to heat-related illnesses and mortality when compared with younger people in the same conditions. This is due to an increased frequency and severity of heatwaves, attributed to climate change, and reduced ability of elderly individuals to dissipate excess heat. Consequently, most excess deaths and emergency visits during heatwaves occur in people aged more than 65 years. The aim of this investigation was to assess the physiological and perceptual responses of elderly people during exercise sessions equating to activities of daily living in UK summer climatic conditions...
June 15, 2018: Public Health
https://www.readbyqxmd.com/read/29914485/white-nose-syndrome-detected-in-bats-over-an-extensive-area-of-russia
#13
Veronika Kovacova, Jan Zukal, Hana Bandouchova, Alexander D Botvinkin, Markéta Harazim, Natália Martínková, Oleg L Orlov, Vladimir Piacek, Alexandra P Shumkina, Mikhail P Tiunov, Jiri Pikula
BACKGROUND: Spatiotemporal distribution patterns are important infectious disease epidemiological characteristics that improve our understanding of wild animal population health. The skin infection caused by the fungus Pseudogymnoascus destructans emerged as a panzootic disease in bats of the northern hemisphere. However, the infection status of bats over an extensive geographic area of the Russian Federation has remained understudied. RESULTS: We examined bats at the geographic limits of bat hibernation in the Palearctic temperate zone and found bats with white-nose syndrome (WNS) on the European slopes of the Ural Mountains through the Western Siberian Plain, Central Siberia and on to the Far East...
June 18, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29914073/effect-of-different-dosages-of-st36-indirect-moxibustion-on-the-skin-temperature-of-the-lower-legs-and-feet
#14
Hiroshi Kuge, Hidetoshi Mori, Tateyuki Morisawa, Kazuyo Hanyu, Junji Miyazaki, Mayumi Watanabe, Tim Hideaki Tanaka
Background: Indirect moxibustion (IM) has been previously performed between the spinous process while recording skin temperature of the trunk. However, moxibustion is often applied not only to acupuncture points on the back, but also to points located on the limbs. Thus, there is a need to investigate skin temperature (ST) responses following IM applied to the limbs. Methods: In Experiment 1 (Exp 1), subjects were randomly assigned to three groups: the left IM stimulation, right IM stimulation and control groups...
June 15, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29913962/offset-analgesia-evoked-by-non-contact-thermal-stimulator
#15
K S Frahm, O K Andersen, L Arendt-Nielsen, C D Mørch
Objective The objective of this study was to test if offset analgesia could be evoked using a noncontact thermal stimulator. Offset analgesia [J. Neurophysiol. 87:2205-2208, 2002] is defined as an unproportionally large decrease in pain intensity following a slight decrease in stimulation intensity. The importance of differences in thermal properties between human hairy and glabrous skin was investigated. Methods A 20W diode laser (970 nm) was used for the thermal stimulation. A fast (50 images/s) infrared camera measured the skin temperature and a temperature controlled feedback control loop adjusted the laser power...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913881/it-s-not-cool-to-reduce-the-skin-temperature-and-activate-the-trpm8-ion-channel-after-spinal-injury
#16
Antti Pertovaara
No abstract text is available yet for this article.
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913841/time-course-of-analgesic-effects-of-botulinum-neurotoxin-type-a-bonta-on-human-experimental-model-of-pain-induced-by-injection-of-glutamate-into-temporalis-muscle
#17
L Bittencourt da Silva, D Kulas, A Karshenas, B E Cairns, F W Bach, L Arendt-Nielsen, P Gazerani
Background/aims Analgesic effects of BoNTA develop within few hours in animal studies and within days in human studies. We have previously shown that BoNTA can block glutamate-induced mechanical sensitization and neurogenic vasodilation in rat temporalis muscle within 3 h. The present translational study was designed to explore the time-course of analgesic effects of BoNTA on pain, sensitization and vasomotor responses in a glutamateevoked human pain model. Methods BoNTA (5U) and saline were injected (30 min interval) into the left and right temporalis muscles of 12 healthy males (24...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911689/rapid-recovery-of-clofazimine-loaded-nanoparticles-with-long-term-storage-stability-as-anti-cryptosporidium-therapy
#18
Jie Feng, Yingyue Zhang, Simon A McManus, Kurt D Ristroph, Hoang D Lu, Kai Gong, Claire E White, Robert K Prud'homme
While the formulation of nanoparticle (NP) suspensions has been widely applied in materials and life science, the recovery of NPs from such a suspension into a solid state is practically important to confer long-term storage stability. However, solidification, while preserving the original nanoscale properties, remains a formidable challenge in the pharmaceutical and biomedical applications of NPs. Herein we combined flash nanoprecipitation (FNP) and spray-drying as a nanofabrication platform for NP formulation and recovery without compromising the dissolution kinetics of the active ingredient...
May 25, 2018: ACS applied nano materials
https://www.readbyqxmd.com/read/29908904/application-of-composite-dissolving-microneedles-with-high-drug-loading-ratio-for-rapid-local-anesthesia
#19
Haohui Zhan, Fengsen Ma, Yingcong Huang, Jie Zhang, Xiayun Jiang, Yongchang Qian
We report a type of dissolving microneedles (DMNs) which was made of composite matrix materials of hydroxypropyl methyl cellulose (HPMC) and poly(methylvinylether‑co‑maleic anhydride) (PMVE/MA copolymer, Gantrez S-97), and was successfully loaded with lidocaine hydrochloride. The weight of lidocaine hydrochloride loaded in the microneedles tip was 70% of the weight of the whole tip. The content was 3.43 ± 0.12 mg in weight, which was determined by high performance liquid chromatography (HPLC). The results for mechanical test showed that these microneedles were able to penetrate into the skin of the experimental animals, that was proved using organic staining, texture analyzer and histological examination...
June 14, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29907354/skin-temperature-response-to-a-liquid-meal-intake-is-different-in-men-than-in-women
#20
Borja Martinez-Tellez, Lourdes Ortiz-Alvarez, Guillermo Sanchez-Delgado, Huiwen Xu, Francisco M Acosta, Elisa Merchan-Ramirez, Victoria Muñoz-Hernandez, Wendy D Martinez-Avila, Miguel A Contreras-Gomez, Angel Gil, Idoia Labayen, Jonatan R Ruiz
BACKGROUND & AIM: The thermic effect of food (TEF) refers to the increase of the metabolic rate and body temperature in response to a single meal. To date, most of the studies have focused to determine the TEF in terms of energy expenditure, but little is known about which is the response in terms of skin temperature. The aim of this study was to analyze whether the thermic effect of food (TEF) on the skin temperature with a standardized and individualized liquid meal test is different in young adult men than in young adult women...
June 2, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
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