Ronald E Warnick, Ian Paddick, David Mathieu, Elizabeth Adam, Christian Iorio-Morin, William Leduc, Andréanne Hamel, Sarah E Johnson, Mohamad Bydon, Ajay Niranjan, L Dade Lunsford, Zhishuo Wei, Kaitlin Waite, Shalini Jose, Selcuk Peker, Mustafa Yavuz Samanci, Ece Tek, Georgios Mantziaris, Stylianos Pikis, Jason P Sheehan, Manjul Tripathi, Narendra Kumar, Juan Diego Alzate, Kenneth Bernstein, Peter Ahorukomeye, Varun R Kshettry, Herwin Speckter, Wenceslao Hernandez, Dušan Urgošík, Roman Liščák, Andrew I Yang, John Y K Lee, Samir Patel, Dorian M Kusyk, Matthew J Shepard, Douglas Kondziolka
OBJECTIVE: Recent studies have suggested that biologically effective dose (BED) is an important correlate of pain relief and sensory dysfunction after Gamma Knife radiosurgery (GKRS) for trigeminal neuralgia (TN). The goal of this study was to determine if BED is superior to prescription dose in predicting outcomes in TN patients undergoing GKRS as a first procedure. METHODS: This was a retrospective study of 871 patients with type 1 TN from 13 GKRS centers. Patient demographics, pain characteristics, treatment parameters, and outcomes were reviewed...
February 16, 2024: Journal of Neurosurgery