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Tek Narayan Maraseni, Kathryn Reardon-Smith, Greg Griffiths, Armando Apan
Savanna fire is a major source of global greenhouse gas (GHG) emissions. In Australia, savanna fire contributes about 3% of annual GHG emissions reportable to the Kyoto Protocol. In order to reduce GHG emissions from savanna burning, the Australian government has developed and approved a Kyoto compliant savanna controlled burning methodology-the first legal instrument of this kind at a global level-under its Emission Reduction Fund. However, this approved methodology is currently only applicable to nine vegetation fuel types across northern parts of Australia in areas which receive on average over 600 mm rainfall annually, covering only 15...
December 2016: Carbon Balance and Management
Ana Isabel Moreno-Calles, Alejandro Casas, Alexis Daniela Rivero-Romero, Yessica Angélica Romero-Bautista, Selene Rangel-Landa, Roberto Alexander Fisher-Ortíz, Fernando Alvarado-Ramos, Mariana Vallejo-Ramos, Dídac Santos-Fita
BACKGROUND: Documenting the spectrum of ecosystem management, the roles of forestry and agricultural biodiversity, TEK, and human culture for food sovereignty, are all priority challenges for contemporary science and society. Ethnoagroforestry is a research approach that provides a theoretical framework integrating socio-ecological disciplines and TEK. We analyze in this study general types of Agroforestry Systems of México, in which peasants, small agriculturalist, and indigenous people are the main drivers of AFS and planning of landscape diversity use...
November 23, 2016: Journal of Ethnobiology and Ethnomedicine
Peichen Pan, Huiyong Sun, Hui Liu, Dan Li, Wenfang Zhou, Xiaotian Kong, Youyong Li, Huidong Yu, Tingjun Hou
The receptor tyrosine kinase Tie-2 is involved in vessel remodeling and maturation, and has been regarded as a potential target for the treatment of various solid tumors. The absence of novel, potent and selective inhibitors severely hampers the understanding of the therapeutic potential of Tie-2. In the present work, we describe the discovery of novel type-I inhibitors of Tie-2 by structure-based virtual screening. Preliminary SAR was also performed based on one active compound, and several novel inhibitors with low micro-molar affinity were discovered...
November 23, 2016: Scientific Reports
Clara Tattoni, Elena Ianni, Davide Geneletti, Paolo Zatelli, Marco Ciolli
In recent decades, a dramatic landscape change has occurred in the European alpine region: open areas have been naturally recolonized by forests as traditional agricultural and forest activities were reduced and reorganized. Land use changes (LUC) are generally measured through GIS and photo interpretation techniques, but despite many studies focused on this phenomenon and its effects on biodiversity and on the environment in general, there is a lack of information about the transformation of the human-environment connection...
November 19, 2016: Science of the Total Environment
Vijaya Kumari, Sandeep Kumar, Inderjeet Kaur, Tek Chand Bhalla
The synthesis of chitosan (Chs) and chitin (Chi) copolymer and grafting of acrylamide (AAm) onto the synthesized copolymer have been carried out by chemical methods. The grafted copolymer was characterized by FTIR, SEM and XRD. The extracellular cutinase of Aspergillus sp. RL2Ct (E.C. was purified to 4.46 fold with 16.1% yield using acetone precipitation and DEAE sepharose ion exchange chromatography. It was immobilized by adsorption on the grafted copolymer. The immobilized enzyme was found to be more stable then the free enzyme and has a good binding efficiency (78...
November 12, 2016: Bioorganic Chemistry
M A Altinoz, B Ince, C Tek, V H Srihari, S Guloksuz
No abstract text is available yet for this article.
November 15, 2016: Molecular Psychiatry
Gordana Pelčić, Silvana Karačić, Galina L Mikirtichan, Olga I/ Kubar, Frank J Leavitt, Michael Cheng-Tek Tai, Naoki Morishita, Suzana Vuletić, Luka Tomašević
No abstract text is available yet for this article.
October 31, 2016: Croatian Medical Journal
Tek N Lamichhane, Anjana Jeyaram, Divya B Patel, Babita Parajuli, Natalie K Livingston, Navein Arumugasaamy, John S Schardt, Steven M Jay
Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as promising drug delivery vehicles for small RNAs (siRNA and miRNA) due to their natural role in intercellular RNA transport. However, the application of EVs for therapeutic RNA delivery may be limited by loading approaches that can induce cargo aggregation or degradation. Here, we report the use of sonication as a means to actively load functional small RNAs into EVs. Conditions under which EVs could be loaded with small RNAs with minimal detectable aggregation were identified, and EVs loaded with therapeutic siRNA via sonication were observed to be taken up by recipient cells and capable of target mRNA knockdown leading to reduced protein expression...
September 2016: Cellular and Molecular Bioengineering
Nicole L De La Mata, Mi-Young Ahn, Nagalingeswaran Kumarasamy, Penh Sun Ly, Oon Tek Ng, Kinh Van Nguyen, Tuti Parwati Merati, Thuy Thanh Pham, Man Po Lee, Nicolas Durier, Matthew G Law
OBJECTIVE: To compare two HIV cohorts to determine whether a pseudo-random sample can represent the entire study population. STUDY DESIGN AND SETTING: HIV-positive patients receiving care at 8 sites in 7 Asian countries. TAHOD pseudo-randomly selected a patient sample, while TAHOD-LITE included all patients. We compared patient demographics, CD4 count and HIV viral load testing for each cohort. Risk factors associated with CD4 count response, HIV viral load suppression (<400 copies/mL) and survival were determined for each cohort...
October 19, 2016: Journal of Clinical Epidemiology
Nam Su Ku, Awachana Jiamsakul, Oon Tek Ng, Evy Yunihastuti, Do Duy Cuong, Man Po Lee, Benedict Lim Heng Sim, Praphan Phanuphak, Wing-Wai Wong, Adeeba Kamarulzaman, Fujie Zhang, Sanjay Pujari, Romanee Chaiwarith, Shinichi Oka, Mahiran Mustafa, Nagalingeswaran Kumarasamy, Kinh Van Nguyen, Rossana Ditangco, Sasisopin Kiertiburanakul, Tuti Parwati Merati, Nicolas Durier, Jun Yong Choi
Elevated CD8 counts with combination antiretroviral therapy (cART) initiation may be an early warning indicator for future treatment failure. Thus, we investigated whether elevated CD8 counts were associated with virological failure (VF) in the first 4 years of cART in Asian HIV-infected patients in a multicenter regional cohort.We included patients from the TREAT Asia HIV Observational Database (TAHOD). Patients were included in the analysis if they started cART between 1996 and 2013 with at least one CD8 measurement within 6 months prior to cART initiation and at least one CD8 and viral load (VL) measurement beyond 6 months after starting cART...
August 2016: Medicine (Baltimore)
Yasemin Yuyucu Karabulut, Mesut Tek, Neslihan Eti, Erdem Akbay
Cholesteatoma in the urinary system is a rarely seen benign condition. Rosina firstly defined this condition in the year 1953. Histopathologically it is characterized with keratinization, and squamous metaplasia of urothelial epithelium associated with desquamation of keratinized layers. Flank pain is the most common symptom that is caused by elimination of keratinous material. In our case we will discuss cholesteatoma developed in an ectopic kidney which has not been described in the literature before.
September 2016: Turkish Journal of Urology
Wen Hui Shaw, Qianqian Lin, Zikry Zhiwei Bin Roslee Muhammad, Jia Jun Lee, Wei Xin Khong, Oon Tek Ng, Eng Lee Tan, Peng Li
INTRODUCTION: Current clinical detection of Human immunodeficiency virus 1 (HIV-1) is used to target viral genes and proteins. However, the immunoassay, such as viral culture or Polymerase Chain Reaction (PCR), lacks accuracy in the diagnosis, as these conventional assays rely on the stable genome and HIV-1 is a highly-mutated virus. Next generation sequencing (NGS) promises to be transformative for the practice of infectious disease, and the rapidly reducing cost and processing time mean that this will become a feasible technology in diagnostic and research laboratories in the near future...
July 2016: Journal of Clinical and Diagnostic Research: JCDR
Lingling Zhang, Zhenzhen Chai, Yu Zhang, Yanfei Geng, Yuahua Wang
BACKGROUND: Since 2009, millions of people have been forced to live under food shortage by the continuous drought in Southwestern China. The market was the primary source of aid grains, and fears that the market will be unable to provide sufficient food make safeguarding food security in the face of climate change crucial. Traditional adaptive strategies of pre-market indigenous people are a potential source of innovation. We studied three questions among the Naxi people: 1) What edible plants did they consume during droughts? 2) How did they produce enough food? 3) How did they consume these plants? This study investigates and documents traditional Naxi food knowledge to safeguard food security during drought and facilitate Chinese policy decisions...
2016: Journal of Ethnobiology and Ethnomedicine
Kalawat Tek Chand, Krishna Kishore Chennu, Lakshmi Amancharla Yadagiri, Ranadheer Manthri Gupta, Ram Rapur, Siva Kumar Vishnubotla
Introduction Studies on fever of unknown origin (FUO) in patients of chronic kidney disease and end stage renal disease patients on dialysis were not many. In this study, we used 18 F-FDG PET/CT scan whole body survey for detection of hidden infection, in patients on dialysis, labelled as FUO. Methods In this retrospective study, 20 patients of end stage renal disease on dialysis were investigated for the cause of FUO using 18F-FDG PET/CT scan. All these patients satisfied the definition of FUO as defined by Petersdorf and Beeson...
September 12, 2016: Hemodialysis International
Berta Almoguera, Lyam Vazquez, Frank Mentch, John Connolly, Jennifer A Pacheco, Agnes S Sundaresan, Peggy L Peissig, James G Linneman, Catherine A McCarty, David Crosslin, David S Carrell, Todd Lingren, Bahram Namjou-Khales, John B Harley, Eric Larson, Gail P Jarvik, Murray Brilliant, Marc S Williams, Iftikhar J Kullo, Erik B Hysinger, Patrick M A Sleiman, Hakon Hakonarson
RATIONALE: Despite significant advances in our knowledge of the genetic architecture of asthma, specific contributors to the variability in the burden between populations remain uncovered. OBJECTIVE: To identify additional genetic susceptibility factors of asthma in European American and African American populations. METHODS: A phenotyping algorithm mining Electronic Medical Records was developed and validated to recruit cases with asthma and controls from the eMERGE (electronic Medical Records and Genomics) network...
September 9, 2016: American Journal of Respiratory and Critical Care Medicine
Sinan Guloksuz, Fangyong Li, Cenk Tek, Scott W Woods, Thomas H McGlashan, Svein Friis, Vinod H Srihari
No abstract text is available yet for this article.
October 1, 2016: JAMA Psychiatry
Christian Couppé, René B Svensson, Katja M Heinemeier, Emilie Wøjdemann Thomsen, Monika Lucia Bayer, Lise Christensen, Michael Kjær, S Peter Magnusson, Peter Schjerling
Increased tendon cell nuclei density (TCND) has been proposed to induce tendon mechanical adaptations. However, it is unknown whether TCND is increased in tendon tissue after mechanical loading and whether such an increase can be quantified in a reliable manner. The aim of this study was to develop a reliable method for quantification of TCND and to investigate potential changes in TCND in rat Achilles tendons in response to 12 weeks of running. Eight adult male Sprague-Dawley rats ran (RUN) on a treadmill with 10° incline, 1 h/day, 5 days/wk (17-20 m/min) for 12 weeks (which improved tendon mechanical properties) and were compared with 11 control rats (SED)...
August 26, 2016: Histochemistry and Cell Biology
Junko Tanuma, Awachana Jiamsakul, Abhimanyu Makane, Anchalee Avihingsanon, Oon Tek Ng, Sasisopin Kiertiburanakul, Romanee Chaiwarith, Nagalingeswaran Kumarasamy, Kinh Van Nguyen, Thuy Thanh Pham, Man Po Lee, Rossana Ditangco, Tuti Parwati Merati, Jun Yong Choi, Wing Wai Wong, Adeeba Kamarulzaman, Evy Yunihastuti, Benedict Lh Sim, Winai Ratanasuwan, Pacharee Kantipong, Fujie Zhang, Mahiran Mustafa, Vonthanak Saphonn, Sanjay Pujari, Annette H Sohn
BACKGROUND: In resource-limited settings, routine monitoring of renal function during antiretroviral therapy (ART) has not been recommended. However, concerns for tenofovir disoproxil fumarate (TDF)-related nephrotoxicity persist with increased use. METHODS: We investigated serum creatinine (S-Cr) monitoring rates before and during ART and the incidence and prevalence of renal dysfunction after starting TDF by using data from a regional cohort of HIV-infected individuals in the Asia-Pacific...
2016: PloS One
Linda Nilsen Ask
Rogaland Council has adopted Universal Design as an overriding principle for all planning and development in the county. Private stakeholders and public agencies collaborated in the development of a successful County Plan for Universal Design that has been recognised as an example of good practice by Norway's public authorities. The plan provides guidelines for both state and municipal planning and operations in several policy areas from public transport to educational and cultural buildings to sports and recreation areas...
2016: Studies in Health Technology and Informatics
André Rolim Belisário, Rahyssa Rodrigues Sales, Nayara Evelin Toledo, Maristela Braga de Sousa Rodrigues Muniz, Cibele Velloso-Rodrigues, Célia Maria Silva, Marcos Borato Viana
Stroke is a severe clinical manifestation of sickle cell anemia (SCA). Despite the prognostic relevance of transcranial Doppler (TCD), more accurate tools to assess stroke risk in children with SCA are required. Here, we describe the effect of clinical, laboratory, and molecular features on the risk of stroke and high-risk TCD in children from the newborn cohort of Minas Gerais, Brazil. Outcomes studied were acute cerebral ischemia and high-risk TCD. Clinical and hematological data were retrieved from children's records...
October 2016: Annals of Hematology
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