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https://www.readbyqxmd.com/read/29106382/angiopoietin-1-is-required-for-schlemm-s-canal-development-in-mice-and-humans
#1
Benjamin R Thomson, Tomokazu Souma, Stuart W Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M Siggs, Liang Feng, Kristina N Whisenhunt, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Christine E Tanna, Alex W Hewitt, David A Mackey, Yasmin S Bradfield, Emmanuelle Souzeau, Shari Javadiyan, Janey L Wiggs, Francesca Pasutto, Xiaorong Liu, Simon Wm John, Jamie E Craig, Jing Jin, Terri L Young, Susan E Quaggin
Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. Here, we describe roles for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure...
November 6, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29104145/the-dual-effects-of-a-novel-peptibody-on-angiogenesis-inhibition-and-m2-macrophage-polarization-on-sarcoma
#2
Xiaoqing Zhu, Jiali Yang, Yanfeng Gao, Chunjing Wu, Lili Yi, Guodong Li, Yuanming Qi
Inhibition of the VEGF/VEGF receptor (VEGFR) and angiopoietin-2 (Ang-2)/TEK receptor tyrosine kinase (Tie-2) pathway is a potential target for tumor angiogenesis. We previously showed that a peptide AS16 which dually inhibits VEGFR/Ang-2 could reduce the tumor growth and decrease the number of microvessels in tumor. However, its short circulating half-life in the serum limits its clinical applications. In this study, as an effort to prolong the short in vivo half-life of AS16, we designed a fusion protein containing peptide AS16 and an IgG Fc fragment...
November 2, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29062004/ethanol-induces-enhanced-vascularization-bioactivity-of-endothelial-cell-derived-extracellular-vesicles-via-regulation-of-micrornas-and-long-non-coding-rnas
#3
Tek N Lamichhane, Christopher A Leung, Lampouguin Yenkoidiok Douti, Steven M Jay
Extracellular vesicles (EVs), such as exosomes, have been identified as regulators of vascular remodeling and have promise as therapeutics for vascularization applications. Towards development of EVs as therapeutics, it has been demonstrated that physiological stimuli of angiogenic phenotypes in EV-producing cells can enhance the potency of EVs for vascularization. The goal of this study was to assess whether ethanol, which induces angiogenic phenotypes in endothelial cells, could be employed to enhance endothelial-derived EV vascularization bioactivity...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29034511/computationally-efficient-combination-of-multi-channel-phase-data-from-multi-echo-acquisitions-aspire
#4
Korbinian Eckstein, Barbara Dymerska, Beata Bachrata, Wolfgang Bogner, Karin Poljanc, Siegfried Trattnig, Simon Daniel Robinson
PURPOSE: To develop a simple method for combining multi-echo phase information from a number of coils in an array that requires no volume coil or additional scans and yields signal-to-noise ratio-optimal images that reflect only ΔB0-related phase. THEORY AND METHODS: Two SNR optimal coil combination methods were developed which retrieve the ΔB0-related phase by determining the coil-dependent phase offsets. The first variant, MCPC-3D-S, requires the unwrapping of one phase image; the second variant, ASPIRE, allows unwrapping to be avoided if two echoes j and k satisfy the echo time relation m⋅TEk=(m+1)⋅TEj, where m is an integer, making this a particularly fast and robust approach...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29027430/-virtual-screening-of-anti-angiogenesis-flavonoids-from-sophora-flavescens
#5
Xi-Xin Chen, Yi Liu, Rong Huang, Lin-Lin Zhao, Lei Chen, Shu-Mei Wang
Angiogenesis is a dynamic, multi-step process. It is known that about 70 diseases are related to angiogenesis. Both the experimental and the literature reports showed that Sophora flavescens inhibit angiogenesis significantly, but the material basis and the mechanism of action have not been clear. In this study, molecular docking was used for screening of anti-angiogenesis flavonoids from the roots of S. flavescens. One handred and twenty-six flavonoids selected from S. flavescens were screened in the docking ligand database with six targets(VEGF-a,TEK,KDR,Flt1,FGFR1 and FGFR2) as the receptors...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29020646/hiv-1-subtype-crf01_ae-and-b-differ-in-utilization-of-low-levels-of-ccr5-maraviroc-susceptibility-and-potential-n-glycosylation-sites
#6
Anjali Joshi, Emily K Cox, Melina J Sedano, Erin B Punke, Raphael Tc Lee, Sebastian Maurer-Stroh, Palvinder Kaur, Oon Tek Ng, Himanshu Garg
HIV subtypes not only predominate in different geographical regions but also differ in key phenotypic characteristics. To determine if genotypic and/or phenotypic differences in the Envelope (Env) glycoprotein can explain subtype related differences, we cloned 37 full length Envs from Subtype B and AE HIV infected individuals from Singapore. Our data demonstrates that CRF01_AE Envs have lower Potential N Glycosylation Sites and higher risk of ×4 development. Phenotypically, CRF01_AE were less infectious than subtype B Envs in cells expressing low levels of CCR5...
December 2017: Virology
https://www.readbyqxmd.com/read/28961876/health-assessments-for-health-governance-concepts-and-methodologies
#7
Rainer Fehr, Kristina Alexanderson, Carlo Favaretti, Judith de Jong, Giuseppe La Torre, Tek-Ang Lim, Piedad Martin-Olmedo, Odile C L Mekel, Kai Michelsen, Nicole Rosenkötter, Marieke Verschuuren, Chiara de Waure, Dineke Zeegers Paget
Background: For better supporting the science-governance interface, the potential of health assessments appears underrated. Aims: To identify what various types of health assessment have in common; how they differ; which assessment(s) to apply for which purpose; and what needs and options there are for future joint development. Methods: This review is based on five types of health assessment: monitoring/surveillance/reporting, assessment of health impact, of health technology, of health systems performance, health-related economic assessment...
August 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28959114/reply-to-the-letter-to-the-editor-for-the-article-entitled-epicardial-adiposity-is-associated-with-microalbuminuria-in-patients-with-essential-hypertension-published-in-the-journal-of-acta-cardiologica-sinica-in-2017-2017-33-74-80
#8
https://www.readbyqxmd.com/read/28955635/optimization-of-physicochemical-parameters-influencing-the-production-of-prodigiosin-from-serratia-nematodiphila-rl2-and-exploring-its-antibacterial-activity
#9
Vijay Singh Gondil, Mohammad Asif, Tek Chand Bhalla
In the present study, role of various physicochemical parameters influencing the production of antimicrobial pigment prodigiosin from Serratia nematodiphila RL2 was determined and optimized. The pigment-producing strain was isolated and based on molecular characterization (16S rRNA sequencing), was identified as S. nematodiphila RL2. The pigment produced by S. nematodiphila RL2 was characterized by thin layer chromatography (Rf 0.94), spectrophotometrically (λmax 535 nm) and identified as prodigiosin. Optimization of production parameters of prodigiosin revealed, nutrient broth medium supplemented with lactose and yeast extract at 1% concentration each, have a positive effect on the bacterial growth (10...
October 2017: 3 Biotech
https://www.readbyqxmd.com/read/28945608/association-of-neutrophil-to-lymphocyte-ratio-and-microalbuminuria-in-patients-with-normal-egfr
#10
Aysun Aybal Kutlugun, Fatma Ayerden Ebinc, Mujgan Tek Ozturk, Fatma Kaplan Efe, İbrahim Karadag, Murat Eser, Oktay Unsal, Serdar Karakaya
AIMS: The aim of this study was to evaluate the association between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and microalbuminuria in patients with normal estimated glomerular filtration rate (eGFR). METHODS: 174 patients who had eGFR≥60 ml/min/1.73 m2 were studied. Patients were divided into two groups according to the urinary albumin excretion as microalbuminuric group (n=105) and normoalbuminuric group (n=69). NLR and PLR levels were calculated...
September 23, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28933705/durability-of-antiretroviral-therapy-regimens-and-determinants-for-change-in-hiv-1-infected-patients-in-the-treat-asia-hiv-observational-database-tahod-lite
#11
Rosario Martinez-Vega, Nicole L De La Mata, Nagalingeswaran Kumarasamy, Penh Sun Ly, Kinh Van Nguyen, Tuti P Merati, Thi Thanh Pham, Man Po Lee, Jun Yong Choi, Jeremy L Ross, Oon Tek Ng
BACKGROUND: The durability of first line regimen is important to achieve long term treatment success for the management of HIV infection. Our analysis describes the duration of sequential ART regimens and identifies the determinants leading to treatment change in HIV-positive patients initiating in Asia. METHODS: All HIV-positive adult patients initiating first-line ART in 2003-2013, from eight clinical sites among seven countries in Asia. Patient follow-up was to May 2014...
September 21, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28932818/impact-of-cell-culture-parameters-on-production-and-vascularization-bioactivity-of-mesenchymal-stem-cell-derived-extracellular-vesicles
#12
Divya B Patel, Kelsey M Gray, Yasasvhinie Santharam, Tek N Lamichhane, Kimberly M Stroka, Steven M Jay
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have emerged as potential therapeutic agents for numerous applications. EVs offer potential advantages over cell-based therapies with regard to safety, stability and clearance profiles, however production and potency limitations must be addressed to enable eventual translation of EV-based approaches. Thus, we sought to examine the role of specific cell culture parameters on MSC EV production and bioactivity toward informing rational design parameters for scalable EV biomanufacturing...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/28861176/prevalence-of-obesity-and-diabetes-in-patients-with-schizophrenia
#13
Aniyizhai Annamalai, Urska Kosir, Cenk Tek
AIM: To compare the prevalence of diabetes in patients with schizophrenia treated at a community mental health center with controls in the same metropolitan area and to examine the effect of antipsychotic exposure on diabetes prevalence in schizophrenia patients. METHODS: The study was a comprehensive chart review of psychiatric notes of patients with schizophrenia and schizoaffective disorder treated at a psychosis program in a community mental health center. Data collected included psychiatric diagnoses, diabetes mellitus diagnosis, medications, allergies, primary care status, height, weight, body mass index (BMI), substance use and mental status exam...
August 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28858824/the-value-of-traditional-ecological-knowledge-for-the-environmental-health-sciences-and-biomedical-research
#14
Symma Finn, Mose Herne, Dorothy Castille
BACKGROUND: Traditional Ecological Knowledge (TEK) is a term, relatively new to Western science, that encompasses a subset of traditional knowledge maintained by Indigenous nations about the relationships between people and the natural environment. The term was first shared by tribal elders in the 1980s to help raise awareness of the importance of TEK. TEK has become a construct that Western scientists have increasingly considered for conducting culturally relevant research with Tribal nations...
August 29, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28837638/ntfp-harvesters-as-citizen-scientists-validating-traditional-and-crowdsourced-knowledge-on-seed-production-of-brazil-nut-trees-in-the-peruvian-amazon
#15
Evert Thomas, Jheyson Valdivia, Carolina Alcázar Caicedo, Julia Quaedvlieg, Lucia Helena O Wadt, Ronald Corvera
Understanding the factors that underlie the production of non-timber forest products (NTFPs), as well as regularly monitoring production levels, are key to allow sustainability assessments of NTFP extractive economies. Brazil nut (Bertholletia excelsa, Lecythidaceae) seed harvesting from natural forests is one of the cornerstone NTFP economies in Amazonia. In the Peruvian Amazon it is organized in a concession system. Drawing on seed production estimates of >135,000 individual Brazil nut trees from >400 concessions and ethno-ecological interviews with >80 concession holders, here we aimed to (i) assess the accuracy of seed production estimates by Brazil nut seed harvesters, and (ii) validate their traditional ecological knowledge (TEK) about the variables that influence Brazil nut production...
2017: PloS One
https://www.readbyqxmd.com/read/28818232/review-of-the-endothelial-pathogenic-mechanism-of-tie2-related-venous-malformation
#16
REVIEW
Zhong Du, JiaWei Zheng, ZhiYuan Zhang, YanAn Wang
BACKGROUND: Venous malformation (VM) is a type of disease involving vascular morphogenesis in humans. Clinically, VM can be sporadic or inherited. TIE2, also known as TEK or HYK, is a member of the receptor tyrosine kinase subfamily and is highly conserved among species. In 1996, an arginine-to-tryptophan substitution at position 849 (R849W) in TIE2 was found to induce hereditary VM. Additional alterations in TIE2 involved in the pathogenesis of inherited or sporadic VM have since been reported...
September 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28811393/analysis-of-geographical-variations-in-the-epidemiology-and-management-of-non-valvular-atrial-fibrillation-results-from-the-ramses-registry
#17
Volkan Doğan, Özcan Başaran, Murat Biteker, Fatma Özpamuk Karadeniz, Ahmet İlker Tekkesin, Yasin Çakıllı, Ceyhan Türkkan, Mehmet Hamidi, Vahit Demir, Mustafa Ozan Gürsoy, Müjgan Tek Öztürk, Gökhan Aksan, Sabri Seyis, Mehmet Ballı, Mehmet Hayri Alıcı, Serdar Bozyel, Cevat Kırma
OBJECTIVE: This study aimed to determine the differences in terms of demographic characteristics and preferred stroke prevention strategies for patients with non-valvular atrial fibrillation living in seven geographical regions of Turkey. METHODS: In total, 6273 patients were enrolled to this prospective, observational RAMSES study. The patients were divided into seven groups based on the geographical region of residence. RESULTS: In terms of the geographical distribution of the overall Turkish population, the highest number of patients were enrolled from Marmara (1677, 26...
October 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28800750/angiopoietin-1-deficiency-increases-tumor-metastasis-in-mice
#18
Iacovos P Michael, Martina Orebrand, Marta Lima, Beatriz Pereira, Olga Volpert, Susan E Quaggin, Marie Jeansson
BACKGROUND: Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of stimuli. Here, we test the hypothesis that loss of Angiopoietin-1/Tek signaling in the vasculature would increase metastasis. METHODS: Angiopoietin-1 was deleted in mice just before birth using floxed Angiopoietin-1 and Tek mice crossed to doxycycline-inducible bitransgenic ROSA-rtTA/tetO-Cre mice...
August 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28791886/-facets-of-body-image-disorder-a-differential-analysis-of-the-tek-kj-test-for-the-detection-of-body-disorder-in-children-and-adolescents-for-the-direct-measurement-of-haptic-perceptual-parts
#19
Julian Rupp, Arne Bürger, Florian Hammerle
There is presently a lack of instruments that measure the haptic-perceptive component of body-image distortion – a central criterion for the eating disorders anorexia nervosa and bulimia nervosa. We present a differential analysis for the Test for Body Image Distortion in Children and Adolescents (BID-CA, German: TEK-KJ) using a large child and adolescents sample, including for the first time male participants. We analyze convergent validity with the Contour Drawing Rating Scale (CDRS) as well as differences between children and adolescents from different type of schools and different BMI percentile groups...
August 9, 2017: Zeitschrift Für Kinder- und Jugendpsychiatrie und Psychotherapie
https://www.readbyqxmd.com/read/28757617/nilotinib-induced-vasculopathy-identification-of-vascular-endothelial-cells-as-a-primary-target-site
#20
E Hadzijusufovic, K Albrecht-Schgoer, K Huber, G Hoermann, F Grebien, G Eisenwort, W Schgoer, S Herndlhofer, C Kaun, M Theurl, W R Sperr, U Rix, I Sadovnik, B Jilma, G H Schernthaner, J Wojta, D Wolf, G Superti-Furga, R Kirchmair, P Valent
The BCR/ABL1 inhibitor Nilotinib is increasingly used to treat patients with chronic myeloid leukemia (CML). Although otherwise well-tolerated, Nilotinib has been associated with the occurrence of progressive arterial occlusive disease (AOD). Our objective was to determine the exact frequency of AOD and examine in vitro and in vivo effects of Nilotinib and Imatinib on endothelial cells to explain AOD-development. In contrast to Imatinib, Nilotinib was found to upregulate pro-atherogenic adhesion-proteins (ICAM-1, E-selectin, VCAM-1) on human endothelial cells...
November 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
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