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Hessa S Alsaif, Arif O Khan, Nisha Patel, Hisham Alkuraya, Mais Hashem, Firdous Abdulwahab, Niema Ibrahim, Mohammed A Aldahmesh, Fowzan S Alkuraya
Primary congenital glaucoma is a trabecular meshwork dysgenesis with resultant increased intraocular pressure and ocular damage. CYP1B1 mutations remain the most common identifiable genetic cause. However, important questions about the penetrance of CYP1B1-related congenital glaucoma remain unanswered. Furthermore, mutations in other genes have been described although their exact contribution and potential genetic interaction, if any, with CYP1B1 mutations are not fully explored. In this study, we employed modern genomic approaches to re-examine CYP1B1-related congenital glaucoma...
March 19, 2018: Human Genetics
Ill-Min Chung, Sung-Kyu Park, Mohd Ali, Mayakrishnan Prabakaran, Young-Tek Oh, Seung-Hyun Kim, Nasir Ali Siddiqui, Ateeque Ahmad
Five new flavonoids namely, 5-hydroxy-6-isoprenyl-7,4'-dimethoxyflavonol-3- O - β -d-arabinofuranoside ( 1 ), 5,7-dihydroxy-4'-methoxyflavone-7- O - β -d-arabinopyranosyl-2''- n -decan-1'''-oate ( 2 ), 3-butanoyl-5,6,8-trihydroxy-7,4'-dimethoxyflavonol--5- O - β -d-glucopyranoside ( 3 ), 7, 4'-dimethoxy-5-hydroxyflavone-5- O - α -d-arabinopyranosyl-(2'' → 1''')- O - α -d-arabinopyranoside ( 4 ), and 5,6-dihydroxy-7, 4'-dimethoxyflavone-5- O - α -d-glucopyranoside ( 5 ), together with two known compounds, were isolated from the methanol extract of Oryza sativa leaves and straw...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Justin O Szot, Hartmut Cuny, Gillian M Blue, David T Humphreys, Eddie Ip, Katrina Harrison, Gary F Sholler, Eleni Giannoulatou, Paul Leo, Emma L Duncan, Duncan B Sparrow, Joshua W K Ho, Robert M Graham, Nicholas Pachter, Gavin Chapman, David S Winlaw, Sally L Dunwoodie
BACKGROUND: Congenital heart disease (CHD)-structural abnormalities of the heart that arise during embryonic development-is the most common inborn malformation, affecting ≤1% of the population. However, currently, only a minority of cases can be explained by genetic abnormalities. The goal of this study was to identify disease-causal genetic variants in 30 families affected by CHD. METHODS: Whole-exome sequencing was performed with the DNA of multiple family members...
March 2018: Circ Genom Precis Med
Sevinç Aktemur Türker, Emel Uzunoğlu, Derya Deniz Sungur, Vildan Tek
INTRODUCTION: This study assessed the fracture resistance (FR) of teeth with simulated perforating internal resorption cavities repaired with different calcium silicate-based cements (CSCs) and backfilling materials. METHODS: Ninety-six mandibular premolar teeth were used. Twelve of the teeth were assigned as negative control group. Remaining roots were instrumented with rotary files, and standardized internal resorption cavities were prepared on the middle half of roots with burs...
March 14, 2018: Journal of Endodontics
Jaime Paneque-Gálvez, Irene Pérez-Llorente, Ana Catarina Luz, Maximilien Guèze, Jean-François Mas, Manuel J Macía, Martí Orta-Martínez, Victoria Reyes-García
It has been suggested that traditional ecological knowledge (TEK) may play a key role in forest conservation. However, empirical studies assessing to what extent TEK is associated with forest conservation compared with other variables are rare. Furthermore, to our knowledge, the spatial overlap of TEK and forest conservation has not been evaluated at fine scales. In this paper, we address both issues through a case study with Tsimane' Amerindians in the Bolivian Amazon. We sampled 624 households across 59 villages to estimate TEK and used remote sensing data to assess forest conservation...
March 12, 2018: Ambio
Columba Monroy-Ortiz, Edmundo García-Moya, Angélica Romero-Manzanares, Mario Luna-Cavazos, Rafael Monroy
This research integrates Traditional and Formal Ecological Knowledge (TEK / FEK) of a Tropical Dry Forest in central Mexico, in order to assess harvesting and conservation of the non-timber forest species. We were interested in: knowing the structure and diversity of the forest community; identifying which are the tree resources of common interest to the users through participatory workshops. A further interest was to identify those resources which are important to local people in terms of preservation; explaining the relationship of the species with some environmental factors; and visualizing which management practices endanger or facilitate the conservation of species...
March 5, 2018: Journal of Environmental Management
David Palecek, Gökçen Tek, Jinggang Lan, Marcella Iannuzzi, Peter Hamm
The vibrational dynamics of Pt-H on a nano-structured platinum surface has been examined by ultrafast infrared spectroscopy. Three bands are observed at 1800 cm-1, 2000 cm-1 and 2090 cm-1, which are assigned to Pt-CO in a bridged and linear configuration, as well as Pt-H, respectively. Lifetime analysis revealed a time constant of (0.8+/-0.1) ps for the Pt-H mode, considerably shorter than that of Pt-CO due to its stronger coupling to the metal substrate. 2D attenuated total reflection (ATR) infrared spectroscopy provided additional evidence for the assignment based on the anharmonic shift, which is large in the case of Pt-H (90 cm-1) in agreement with the DFT calculations...
February 23, 2018: Journal of Physical Chemistry Letters
Ke-Ling Wang, Shu-Fang Ma, Ling-Yu Pang, Meng-Na Zhang, Lin-Yan Hu, Meng-Jia Liu, Li-Ping Zou
RATIONALE: Blue rubber bleb nevus syndrome (BRBNS) is a rare disease characterized by multiple venous malformations. The gastrointestinal bleeding and secondary iron deficiency anemia are the most common complications. There are currently no effective treatments for BRBNS. Here, we report a case of successful treatment with a small dose of sirolimus of a BRBN patient with a de novo gene mutation. PATIENT CONCERNS: A 12-year-old female was admitted to our hospital with multiple hemangiomas for 12 years...
February 2018: Medicine (Baltimore)
Owain R Edwards, Thomas K Walsh, Suzanne Metcalfe, Wee Tek Tay, Ary A Hoffmann, Peter Mangano, Alan Lord, Svetlana Micic, Paul A Umina
Resistance mechanisms are typically uncovered by identifying sequence variation in known candidate genes, however this strategy can be problematic for species with no reference data in known relatives. Here we take a genomic approach to identify resistance to pyrethroids in the redlegged earth mite, Halotydeus destructor, a member of the Penthalidae family of mites that are virtually uncharacterized genetically. Based on shallow genome sequencing followed by a genome assembly, we first identified contigs of the H...
January 2018: Pesticide Biochemistry and Physiology
Wen Tian, Yong-Sheng Li, Jing-Hua Zhang, Ji-Jun Li, Jing-Hua Gao
Due to the high mortality of lung cancer, early diagnosis followed by early effective treatment is the key to prognosis improvement, which demands to identify the biological targets. Therefore, a multistage screening analysis was used to identify biological targets of lung adenocarcinoma. Two independent datasets of DNA methylation and RNA expression microarray in lung adenocarcinoma and normal lung tissues were chosen from the Gene Expression Omnibus. The association between DNA methylation and gene expression was explored, and the prognostic value of the hub genes was also evaluated...
February 14, 2018: DNA and Cell Biology
Ee Lin Tek, Joanna F Sundstrom, Jennie M Gardner, Stephen G Oliver, Vladimir Jiranek
Commercially available active dried wine yeasts are regularly used by winemakers worldwide to achieve reliable fermentations and obtain quality wine. This practice has led to increased evidence of traces of commercial wine yeast in the vineyard, winery and uninoculated musts. The mechanism(s) that enables commercial wine yeast to persist in the winery environment and the influence to native microbial communities on this persistence is poorly understood. This study has investigated the ability of commercial wine yeasts to form biofilms and adhere to plastic...
January 31, 2018: FEMS Microbiology Ecology
Ugonna C Ijeoma, Sin Sansam, Sok Srun, Hoy Vannara, Sou Sanith, Tek Sopheap, Robert D Newman, Renuka Gadde, Selenic Dejana, Ahmed Saadani Hassani, Vanthy Ly, Bakary Drammeh, Anindya De, Johnita Byrd, Naomi Bock
No abstract text is available yet for this article.
February 2, 2018: MMWR. Morbidity and Mortality Weekly Report
Tek Chand Bhalla, Vijay Kumar, Virender Kumar, Neerja Thakur, Savitri
Nitrile metabolizing enzymes, i.e., aldoxime dehydratase, hydroxynitrile lyase, nitrilase, nitrile hydratase, and amidase, are the key catalysts in carbon nitrogen triple bond anabolism and catabolism. Over the past several years, these enzymes have drawn considerable attention as prominent biocatalysts in academia and industries because of their wide applications. Research on various aspects of these biocatalysts, i.e., sources, screening, function, purification, molecular cloning, structure, and mechanisms, has been conducted, and bioprocesses at various scales have been designed for the synthesis of myriads of useful compounds...
January 30, 2018: Applied Biochemistry and Biotechnology
Narel Y Paniagua-Zambrana, Rainer W Bussmann, Robbie E Hart, Araceli L Moya-Huanca, Gere Ortiz-Soria, Milton Ortiz-Vaca, David Ortiz-Álvarez, Jorge Soria-Morán, María Soria-Morán, Saúl Chávez, Bertha Chávez-Moreno, Gualberto Chávez-Moreno, Oscar Roca, Erlin Siripi
BACKGROUND: That the answers elicited through interviews may be influenced by the knowledge of the interviewer is accepted across disciplines. However, in ethnobotany, there is little evidence to quantitatively assess what impact this effect may have. We use the results of a large study of traditional ecological knowledge (TEK) of plant use of the Chácobo and Pacahuara of Beni, Bolivia, to explore the effects of interviewer identity and knowledge upon the elicited plant species and uses...
January 26, 2018: Journal of Ethnobiology and Ethnomedicine
Tomokazu Souma, Benjamin R Thomson, Stefan Heinen, Isabel Anna Carota, Shinji Yamaguchi, Tuncer Onay, Pan Liu, Asish K Ghosh, Chengjin Li, Vera Eremina, Young-Kwon Hong, Aris N Economides, Dietmar Vestweber, Kevin G Peters, Jing Jin, Susan E Quaggin
The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Using conditional knockout studies in mice, we show TIE2 is predominantly activated by ANGPT1 in the cardiovascular system and by ANGPT2 in the lymphatic vasculature. Mechanisms underlying opposing actions of ANGPT2 in blood vs...
January 22, 2018: Proceedings of the National Academy of Sciences of the United States of America
Nikhil Sharma, Ruchi Verma, Savitri, Tek Chand Bhalla
ProCos (Protein Composition Server, script version), one of the machine learning techniques, was used to classify nitrilases as aliphatic and aromatic nitrilases. Some important feature vectors were used to train the algorithm, which included pseudo-amino acid composition (PAAC) and five-factor solution score (5FSS). This clearly differentiated into two groups of nitrilases, i.e., aliphatic and aromatic, achieving maximum sensitivity of 100.00%, specificity of 90.00%, accuracy of 95.00% and Mathew Correlation Coefficient (MCC) of about 0...
January 2018: 3 Biotech
Junjie Piao, Jie Sun, Yang Yang, Tiefeng Jin, Liyan Chen, Zhenhua Lin
BACKGROUND: Non-small cell lung cancer (NSCLC) is the major leading cause of cancer-related deaths worldwide. This study aims to explore molecular mechanism of NSCLC. METHODS: Microarray dataset was obtained from the Gene Expression Omnibus (GEO) database, and analyzed by using GEO2R. Functional and pathway enrichment analysis were performed based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Then, STRING, Cytoscape and MCODE were applied to construct the Protein-protein interaction (PPI) network and screen hub genes...
March 20, 2018: Gene
Hyun Beom Song, Se Yeon Park, Jung Hwa Ko, Jong Woo Park, Chang Ho Yoon, Dong Hyun Kim, Jeong Hun Kim, Mee Kum Kim, Ryang Hwa Lee, Darwin J Prockop, Joo Youn Oh
The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis and lymphangiogenesis in the cornea, compromising transparency and visual acuity. Mesenchymal stem/stromal cells (MSCs) have therapeutic potentials in a variety of diseases because of anti-inflammatory properties. Herein, we investigated the effects of MSCs on corneal angiogenesis using a model of suture-induced inflammatory corneal neovascularization. Data demonstrated that an intravenous administration of MSCs suppressed corneal inflammation and neovascularization, inhibiting both hemangiogenesis and lymphangiogenesis...
January 3, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Abolfazl Bahrami, Seyed Reza Miraie-Ashtiani, Mostafa Sadeghi, Ali Najafi, Reza Ranjbar
BACKGROUND: TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differentiation, migration, adhesion, proliferation, survival and protein synthesis. RESULTS: TEK signaling on each of the two important pathways where levels of pERK, pMYC, pAkt, pMCL1 and pEIF4EBP1 are increased in dominant follicles and pMYC is decreased in dominant follicles...
December 19, 2017: Journal of Ovarian Research
In Young Jung, David Boettiger, Wing Wai Wong, Man Po Lee, Sasisopin Kiertiburanakul, Romanee Chaiwarith, Anchalee Avihingsanon, Junko Tanuma, Nagalingeswaran Kumarasamy, Adeeba Kamarulzaman, Fujie Zhang, Pacharee Kantipong, Oon Tek Ng, Benedict Lim Heng Sim, Matthew Law, Jeremy Ross, Jun Yong Choi
INTRODUCTION: Although substitutions of antiretroviral regimen are generally safe, most data on substitutions are based on results from clinical trials. The objective of this study was to evaluate the treatment outcomes of substituting antiretroviral regimen in virologically suppressed HIV-infected patients in non-clinical trial settings in Asian countries. METHODS: The study population consisted of HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD)...
December 2017: Journal of the International AIDS Society
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