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https://www.readbyqxmd.com/read/28432873/conditional-deletion-of-bmal1-accentuates-microvascular-and-macrovascular-injury
#1
Ashay D Bhatwadekar, Eleni Beli, Diao Yanpeng, Jonathan Chen, Qianyi Luo, Alpha Alex, Sergio Caballero, James M Dominguez, Tatiana E Salazar, Julia V Busik, Mark S Segal, Maria B Grant
The brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein (BMAL)-1 constitutes a major transcriptional regulator of the circadian clock. Here, we explored the impact of conditional deletion of Bmal1 in endothelium and hematopoietic cells in murine models of microvascular and macrovascular injury. We used two models of Bmal1(fx/fx);Tek-Cre mice, a retinal ischemia/reperfusion model and a neointimal hyperplasia model of the femoral artery. Eyes were enumerated for acellular capillaries and were stained for oxidative damage markers using nitrotyrosine immunohistochemistry...
April 19, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28408355/down-regulation-of-dlc1-in-endothelial-cells-compromises-the-angiogenesis-process
#2
Yi-Ping Shih, Sarah Y Yuan, Su Hao Lo
DLC1 is a RhoGAP-containing tumor suppressor that inhibits angiogenesis by repressing VEGF production in epithelial cells. Here we report the roles of DLC1 in endothelial cells. Silencing of DLC1 (siDLC1) enhances cell migration but reduces tube formation activities of human umbilical vein endothelial cells (HUVECs). Biochemically, RhoA activity and paxillin protein level are markedly increased in siDLC1 HUVECs. Although further silencing of RhoA restores the cell migration phenotype, the tube formation defect and up-regulated paxillin level remain unchanged...
April 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28394435/real-world-clinical-characteristics-and-treatment-patterns-of-individuals-aged-80-and-older-with-nonvalvular-atrial-fibrillation-results-from-the-real-life-multicenter-survey-evaluating-stroke-study
#3
Murat Biteker, Özcan Başaran, Volkan Doğan, İbrahim Altun, Fatma Özpamuk Karadeniz, Ahmet İlker Tekkesin, Yasin Çakıllı, Ceyhan Türkkan, Mehmet Hamidi, Vahit Demir, Mustafa Ozan Gürsoy, Müjgan Tek Öztürk, Gökhan Aksan, Sabri Seyis, Mehmet Ballı, Mehmet Hayri Alıcı, Serdar Bozyel
OBJECTIVES: To compare the clinical characteristics of and use of oral anticoagulant (OAC) therapy in individuals aged 80 and older with atrial fibrillation (AF) with those of individuals younger than 80 with AF in clinical practice. DESIGN: Observational study. SETTING: The ReAl-life Multicenter Survey Evaluating Stroke prevention strategies in Turkey trial (NCT02344901), a national observational registry. PARTICIPANTS: Turkish adults with nonvalvular AF (NVAF)...
April 10, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28379155/beam-on-imaging-of-short-lived-positron-emitters-during-proton-therapy
#4
Hans Jan Thomas Buitenhuis, Faruk Diblen, Karol Brzezinski, Sytze Brandenburg, Peter Dendooven
In-vivo dose delivery verification in proton therapy can be performed by positron emission tomography (PET) of the positron-emitting nuclei produced by the proton beam in the patient. A PET scanner installed in the treatment position of a proton therapy facility that takes data with the beam on will see very short-lived nuclides as well as longer-lived nuclides. The most important short-lived nuclide for proton therapy is <sup>12</sup>N (Dendooven <i>et al</i> 2015), which has a half-life of 11 ms...
April 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28350004/mitochondrial-dna-and-trade-data-support-multiple-origins-of-helicoverpa-armigera-lepidoptera-noctuidae-in-brazil
#5
Wee Tek Tay, Thomas K Walsh, Sharon Downes, Craig Anderson, Lars S Jermiin, Thomas K F Wong, Melissa C Piper, Ester Silva Chang, Isabella Barony Macedo, Cecilia Czepak, Gajanan T Behere, Pierre Silvie, Miguel F Soria, Marie Frayssinet, Karl H J Gordon
The Old World bollworm Helicoverpa armigera is now established in Brazil but efforts to identify incursion origin(s) and pathway(s) have met with limited success due to the patchiness of available data. Using international agricultural/horticultural commodity trade data and mitochondrial DNA (mtDNA) cytochrome oxidase I (COI) and cytochrome b (Cyt b) gene markers, we inferred the origins and incursion pathways into Brazil. We detected 20 mtDNA haplotypes from six Brazilian states, eight of which were new to our 97 global COI-Cyt b haplotype database...
March 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330252/organic-solvent-tolerant-metallo-protease-of-novel-isolate-serratia-marcescens-ppb-26-production-and-characterization
#6
Shikha Thakur, Nirmal Kant Sharma, Neerja Thakur, Savitri, Tek Chand Bhalla
Proteases are a class of enzymes that catalyze hydrolysis of peptide bonds of proteins. In this study, 221 proteolytic bacterial isolates were obtained by enrichment culture method from soils of various regions of Himachal Pradesh, India. From these a hyper producer of protease was screened and identified by morphological and physiological testing and by 16S rDNA sequence as Serratia marcescens PPB-26. Statistical optimization of physiochemical parameters enhanced the protease production by 75 %. Protease of S...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330221/optimization-of-medium-parameters-by-response-surface-methodology-rsm-for-enhanced-production-of-cutinase-from-aspergillus-sp-rl2ct
#7
Vijaya Kumari, Vijay Kumar, Ravin Chauhan, Mohammad Asif, Tek Chand Bhalla
Cutinases are hydrolytic enzymes which catalyzes esterification and trans-esterification reactions that make them highly potential industrial biocatalyst. In the present investigation microorganisms showing cutinase activity were isolated from plant samples. The strain showing maximum cutinase activity was identified by 18S rDNA sequencing as Aspergillus sp. RL2Ct and was selected for further studies. To achieve maximum enzyme production, the medium components affecting cutinase production were screened by Plackett-Burman followed by central composite design...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28330136/enhanced-production-of-thermostable-amidase-from-geobacillus-subterraneus-rl-2a-mtcc-11502-via-optimization-of-physicochemical-parameters-using-taguchi-doe-methodology
#8
Praveen Kumar Mehta, Shashi Kant Bhatia, Ravi Kant Bhatia, Tek Chand Bhalla
The specific effect of chemical and physical factors on amidase production from Geobacillus subterraneus RL-2a was investigated using design of experiments (DOE) methodology. The one-factor-at-a-time (OFAT) method was used to study the effects of carbon and nitrogen sources on amidase production. Subsequently, optimal levels of physical parameters and key media components, namely temperature, pH, sucrose, K2HPO4, NaCl, yeast, CaCl2·2H2O and MgSO4·7H2O, were determined using the Taguchi orthogonal array (OA) experimental design (DOE) methodology...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28320530/single-cell-rna-sequence-analysis-of-mouse-glomerular-mesangial-cells-uncovers-mesangial-cell-essential-genes
#9
Yuqiu Lu, Yuting Ye, Qianqian Yang, Shaolin Shi
Mesangial cells are essential for the structure and function of glomeruli, but the mechanisms underlying these roles are not well understood. Here, we performed a single-cell RNA-sequence (RNA-seq) analysis of mouse mesangial cells using the Fluidigm C1 platform. We found that gene expression in individual mesangial cells was tremendously heterogeneous, with mean correlation coefficients of 0.20, and most mesangial genes were actually expressed in only a portion of mesangial cells and are therefore presumably dispensable...
March 17, 2017: Kidney International
https://www.readbyqxmd.com/read/28316284/facial-cutaneo-mucosal-venous-malformations-can-develop-independently-of-mutation-of-tek-gene-%C3%AF-but-may-be-associated-with-excessive-expression-of-src-and-p-src
#10
Nabila Brahami, Selvakumar Subramaniam, Moudjahed Saleh Al-Ddafari, Cecile Elkaim, Pierre-Olivier Harmand, Badr-Eddine Sari, Gérard Lefranc, Mourad Aribi
We aimed to search for mutations in the germline and somatic DNA of the TEK gene and to analyze the expression level of Src and phospho-Src (p-Src) in tumor and healthy tissues from patients with facial cutaneo-mucosal venous malformations (VMCM). Eligible patients from twelve families and thirty healthy controls were recruited respectively at the Departments of Stomatology and Oral Surgery, and Transfusion Medicine of Tlemcen University Medical Centre. Immunoblot analyses of Src and p-Src were performed after direct DNA sequencing...
March 20, 2017: Journal of Negative Results in Biomedicine
https://www.readbyqxmd.com/read/28295905/alpha-lipoic-acid-ala-as-a-supplementation-for-weight-loss-results-from-a-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
S Kucukgoncu, E Zhou, K B Lucas, C Tek
OBJECTIVES: Obesity is associated with significant morbidity and mortality rates. Even modest weight loss may be associated with health benefits. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant. Studies have suggested anti-obesity properties of ALA; however, results are inconsistent. The purpose of this study is to conduct a meta-analysis of the effect of ALA on weight and body mass index (BMI). METHODS: A comprehensive, systematic literature search identified 10 articles on randomized, double-blind, placebo-controlled studies involving ALA...
May 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28291735/cd4-cd8-ratio-comparison-between-cohorts-of-hiv-positive-asians-and-caucasians-upon-commencement-of-antiretroviral-therapy
#12
Kathy Petoumenos, Jun Yong Choi, Jennifer Hoy, Sasisopin Kiertiburanakul, Oon Tek Ng, Mark Boyd, Reena Rajasuriar, Matthew Law
BACKGROUND: In the era of effective antiretroviral treatment (ART) CD4:CD8 ratio is proposed as a potential marker for HIV-positive (HIV+) patients at increased risk for non-AIDS comorbidities. The current study aims to compare CD4:CD8 ratio between Asian and Caucasian HIV+ patients. METHODS: HIV+ patients from the Australian HIV Observational Database (AHOD) and the TREAT Asia HIV Observational Database (TAHOD) meeting specific criteria were included. In these analyses Asian and Caucasian status were defined by cohort...
March 14, 2017: Antiviral Therapy
https://www.readbyqxmd.com/read/28281637/direct-nitrous-oxide-emissions-from-tropical-and-sub-tropical-agricultural-systems-a-review-and-modelling-of-emission-factors
#13
Fabrizio Albanito, Ulrike Lebender, Thomas Cornulier, Tek B Sapkota, Frank Brentrup, Clare Stirling, Jon Hillier
There has been much debate about the uncertainties associated with the estimation of direct and indirect agricultural nitrous oxide (N2O) emissions in developing countries and in particular from tropical regions. In this study, we report an up-to-date review of the information published in peer-review journals on direct N2O emissions from agricultural systems in tropical and sub-tropical regions. We statistically analyze net-N2O-N emissions to estimate tropic-specific annual N2O emission factors (N2O-EFs) using a Generalized Additive Mixed Model (GAMM) which allowed the effects of multiple covariates to be modelled as linear or smooth non-linear continuous functions...
March 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28268713/investigations-on-different-epoxies-for-electrical-insulation-of-microflex-structures
#14
P Cvancara, S Lauser, L Rudmann, T Stieglitz
The microflex interconnection (MFI) technique is often used to connect electrically and mechanically thin film ribbons or electrodes with a solid substrate like screen printed ceramics. For stabilization reasons epoxy is used to fix the MFI structure. As epoxy tends to form cracks when surrounded by water or electrolytes we are eager to find an epoxy which provides sufficient insulation between the single channels of the MFI structure also in a moist surrounding. Therefore we designed a device to investigate the insulating properties of different epoxies (Uhu Plus Endfest 300, Epo-Tek 353ND and 353ND-T) immersed in saline solution...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268707/epoxy-casting-used-as-nonhermetic-encapsulation-technique-for-implantable-electronic-devices
#15
Fabian Boeser, Benjamin G Lang, Thomas Stieglitz, Dennis T T Plachta
Implantable medical applications experienced a rapid growth since starting in the late 1950s with the first pacemakers. However, there are only two main packaging strategies available to protect the implanted electronics from the body environment. While hermetic packaging oftentimes seems to be more feasible, nonhermetic encapsulation can be an alternative under certain conditions. Previous studies using commercially available USB flash drives (UFD) pointed out the feasibility of using epoxy resins as encapsulant material...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267699/hiv-and-aging-demographic-change-in-the-asia-pacific-region
#16
Rainer Puhr, Nagalingeswaran Kumarasamy, Penh Sun Ly, Oon Tek Ng, Kinh Van Nguyen, Tuti Parwati Merati, Thuy Thanh Pham, Man Po Lee, Jun Yong Choi, Jeremy L Ross, Matthew G Law
No abstract text is available yet for this article.
April 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28265049/the-ethics-of-betel-nut-consumption-in-taiwan
#17
Joseph Tham, Geoffrey Sem, Eugene Sit, Michael Cheng-Tek Tai
The ethics of betel nut use in Taiwan are examined in this article. It first presents scientific facts about the betel quid, its consumption and negative health consequences and then analyses the cultural background and economic factors contributing to its popularity in Asia. Governmental and institutional attempts to curb betel nut cultivation, distribution and sales are also described. Finally, the bioethical implications of this often ignored subject are considered.
March 6, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28263441/-form-is-easy-meaning-is-hard-revisited-re-characterizing-the-strengths-and-weaknesses-of-language-in-children-with-autism-spectrum-disorder
#18
REVIEW
Letitia R Naigles, Saime Tek
Children with autism spectrum disorder (ASD) demonstrate impairments in social interaction and communication, and in repetitive/stereotypical behaviors. The degree to which children with ASD also manifest impairments in structural language-such as lexicon and grammar-is currently quite controversial. We reframe this controversy in terms of Naigles' (Naigles, Cognition 2002, 86: 157-199) 'form is easy, meaning is hard' thesis, and propose that the social difficulties of children with ASD will lead the meaning-related components of their language to be relatively more impaired than the form-related components...
March 6, 2017: Wiley Interdisciplinary Reviews. Cognitive Science
https://www.readbyqxmd.com/read/28248115/engineered-multivalency-enhances-affibody-based-her3-inhibition-and-downregulation-in-cancer-cells
#19
John S Schardt, Jinan M Oubaid, Sonya C Williams, James L Howard, Chloe M Aloimonos, Michelle L Bookstaver, Tek N Lamichhane, Sonja Sokic, Mariya S Liyasova, Maura O'Neill, Thorkell Andresson, Arif Hussain, Stanley Lipkowitz, Steven M Jay
The receptor tyrosine kinase HER3 has emerged as a therapeutic target in ovarian, prostate, breast, lung, and other cancers due to its ability to potently activate the PI3K/Akt pathway, especially via dimerization with HER2, as well as for its role in mediating drug resistance. Enhanced efficacy of HER3-targeted therapeutics would therefore benefit a wide range of patients. This study evaluated the potential of multivalent presentation, through protein engineering, to enhance the effectiveness of HER3-targeted affibodies as alternatives to monoclonal antibody therapeutics...
April 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28247524/assessment-of-heart-rate-response-to-exercise-and-recovery-during-treadmill-testing-in-arsenic-exposed-workers
#20
Ugur Nadir Karakulak, Meside Gunduzoz, Mehmet Ayturk, Mujgan Tek Ozturk, Engin Tutkun, Omer Hinc Yilmaz
BACKGROUND: Arsenic exposure is associated with various cardiovascular diseases. The aim of the present study was to assess cardiac autonomic function via heart rate response to exercise and recovery period of treadmill testing in arsenic-exposed workers. METHODS: Sixty-five (65) occupationally arsenic-exposed workers and 35 healthy controls were enrolled. Blood and urinary arsenic levels were analyzed and symptom limited maximal treadmill exercise test were performed...
March 1, 2017: Annals of Noninvasive Electrocardiology
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