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https://www.readbyqxmd.com/read/28148994/greenhouse-gas-emissions-from-agricultural-food-production-to-supply-indian-diets-implications-for-climate-change-mitigation
#1
Sylvia H Vetter, Tek B Sapkota, Jon Hillier, Clare M Stirling, Jennie I Macdiarmid, Lukasz Aleksandrowicz, Rosemary Green, Edward J M Joy, Alan D Dangour, Pete Smith
Agriculture is a major source of greenhouse gas (GHG) emissions globally. The growing global population is putting pressure on agricultural production systems that aim to secure food production while minimising GHG emissions. In this study, the GHG emissions associated with the production of major food commodities in India are calculated using the Cool Farm Tool. GHG emissions, based on farm management for major crops (including cereals like wheat and rice, pulses, potatoes, fruits and vegetables) and livestock-based products (milk, eggs, chicken and mutton meat), are quantified and compared...
January 16, 2017: Agriculture, Ecosystems & Environment
https://www.readbyqxmd.com/read/28132544/growing-challenges-for-hiv-programmes-in-asia-clinic-population-trends-2003-2013
#2
Nicole L De La Mata, Nagalingeswaran Kumarasamy, Penh Sun Ly, Oon Tek Ng, Kinh Van Nguyen, Tuti Parwati Merati, Man Po Lee, Cuong Duy Do, Jun Yong Choi, Jeremy L Ross, Matthew G Law
The scale-up of antiretroviral therapy (ART) has led to a substantial change in the clinical population of HIV-positive patients receiving care. We describe the temporal trends in the demographic and clinical characteristics of HIV-positive patients initiating ART in 2003-13 within an Asian regional cohort. All HIV-positive adult patients that initiated ART between 2003 and 2013 were included. We summarized ART regimen use, age, CD4 cell count, HIV viral load, and HIV-related laboratory monitoring rates during follow-up by calendar year...
January 29, 2017: AIDS Care
https://www.readbyqxmd.com/read/28129256/loss-to-follow-up-trends-in-hiv-positive-patients-receiving-antiretroviral-treatment-in-asia-from-2003-to-2013
#3
Nicole L De La Mata, Penh Sun Ly, Kinh Van Nguyen, Tuti Parwati Merati, Thuy Thanh Pham, Man Po Lee, Jun Yong Choi, Jeremy Ross, Matthew G Law, Oon Tek Ng
INTRODUCTION: Over time there has been substantial improvement in antiretroviral treatment (ART) programmes, including expansion of services and increased patient engagement. We describe time trends in, and factors associated with, loss to follow-up (LTFU) in HIV4 positive patients receiving ART in Asia. METHODS: Analysis included HIV-positive adults initiating ART in 2003-2013 at seven ART programmes in Asia. Patients LTFU had not attended the clinic for ≥180days, had not died or transferred to another clinic...
January 25, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28125325/in-vivo-gene-expression-profiling-for-chemosensitivity-to-docetaxel-cisplatin-5-fu-tpf-triplet-regimen-in-laryngeal-squamous-cell-carcinoma-and-the-effect-of-tpf-treatment-on-related-gene-expression-in-vitro
#4
Meng Lian, Qian Shi, Jugao Fang, Ling Feng, Hongzhi Ma, Haizhou Wang, Liang Zhang, Hong Wang, Zhihong Ma, Honggang Liu
CONCLUSION: These results provided a battery of genes relating to TPF chemotherapeutic sensitivity and might act as molecular targets in laryngeal squamous cell carcinoma (LSCC) treatment. Moreover, these candidate biomarkers could contribute to LSCC individualized treatment. OBJECTIVES: To screen out a set of candidate genes which could help to determine whether patients with LSCC could benefit from TPF induction chemotherapy. METHOD: Gene-expression profiles in seven TPF-sensitive patients were compared to four resistant controls by microarray analysis...
January 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28115810/epicardial-adiposity-is-associated-with-microalbuminuria-in-patients-with-essential-hypertension
#5
Mujgan Tek Ozturk, Fatma Ayerden Ebinç, Gülay Ulusal Okyay, Aysun Akbal Kutlugün
BACKGROUND: Measurement of epicardial adipose tissue (EAT) is suggested as a novel cardiometabolic risk factor. Microalbuminuria is a marker of endothelial dysfunction and is associated with an increased risk for cardiovascular disease in patients with systemic hypertension. The aim of this study was to investigate the relationship of echocardiographic epicardial adipose tissue (EAT) thickness and microalbuminuria in hypertensive patients. METHODS: 75 essential hypertensive patients were included into the study...
January 2017: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/28087270/examining-the-reliability-and-validity-of-the-clinical-assessment-interview-for-negative-symptoms-within-the-management-of-schizophrenia-in-clinical-practice-mosaic-multisite-national-study
#6
Jack J Blanchard, Kristen R Bradshaw, Cristina P Garcia, Henry A Nasrallah, Philip D Harvey, Daniel Casey, Csilla T Csoboth, James I Hudson, Laura Julian, Ellen Lentz, Keith H Nuechterlein, Diana O Perkins, Tracey G Skale, Lonnie R Snowden, Rajiv Tandon, Cenk Tek, Dawn Velligan, Sophia Vinogradov, Cedric O'Gorman
The current study sought to expand on prior reports of the validity and reliability of the CAINS (CAINS) by examining its performance across diverse non-academic clinical settings as employed by raters not affiliated with the scale's developers and across a longer test-retest follow-up period. The properties of the CAINS were examined within the Management of Schizophrenia in Clinical Practice (MOSAIC) schizophrenia registry. A total of 501 participants with a schizophrenia spectrum diagnosis who were receiving usual care were recruited across 15 national Patient Assessment Centers and evaluated with the CAINS, other negative symptom measures, and assessments of functioning, quality of life and cognition...
January 11, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28086839/ethnobotanical-knowledge-acquisition-during-daily-chores-the-firewood-collection-of-pastoral-maasai-girls-in-southern-kenya
#7
Xiaojie Tian
BACKGROUND: Researchers considering children's traditional ecological knowledge (TEK) highlighted the importance of examining children's daily activities as empirical contexts for its acquisition. Many of them evaluated children's TEK acquisition linearly as gain or loss, and paid less attention to the adaptive nature of this knowledge system and the social relationships arising from its acquisition processes. This study approaches children's TEK acquisition considering these abovementioned aspects...
January 13, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28053625/lipid-raft-integrity-is-required-for-survival-of-triple-negative-breast-cancer-cells
#8
Anil Badana, Madhuri Chintala, Gayathri Varikuti, Nagaseshu Pudi, Seema Kumari, Vijaya Rachel Kappala, Rama Rao Malla
PURPOSE: Lipid rafts are cholesterol enriched microdomains that colocalize signaling pathways involved in cell proliferation, metastasis, and angiogenesis. We examined the effect of methyl-β-cyclodextrin (MβCD)-mediated cholesterol extraction on the proliferation, adhesion, invasion, and angiogenesis of triple negative breast cancer (TNBC) cells. METHODS: We measured cholesterol and estimated cell toxicity. Detergent resistant membrane (DRM) and non-DRM fractions were separated using the OptiPrep gradient method...
December 2016: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28045923/germline-genetic-variants-in-tek-angpt1-angpt2-mmp9-fgf2-and-vegfa-are-associated-with-pathologic-complete-response-to-bevacizumab-in-breast-cancer-patients
#9
Issam Makhoul, Valentina K Todorova, Eric R Siegel, Stephen W Erickson, Ishwori Dhakal, Vinay R Raj, Jeannette Y Lee, Mohammed S Orloff, Robert J Griffin, Ronda S Henry-Tillman, Suzanne Klimberg, Laura F Hutchins, Susan A Kadlubar
BACKGROUND: We previously reported improved pathologic complete response (pCR) in a prospective phase II study using neoadjuvant bevacizumab in combination with chemotherapy compared to chemotherapy alone in breast cancer patients (41% vs. 25%, p = 0.0291). In this study, we queried germline single-nucleotide polymorphisms (SNPs) in angiogenesis-related genes for their impact on pCR and overall survival (OS). METHODS: DNA for genotyping was available from 34 subjects who received bevacizumab in addition to chemotherapy and 29 subjects who did not...
2017: PloS One
https://www.readbyqxmd.com/read/28010758/double-jeopardy-the-rubber-ball-bounces-twice
#10
Jack L Arbiser, Linda C Gilbert
Soblet et al. describe cis mutations in TEK/Tie-2 in blue rubber bleb nevus and sporadic vascular malformations. This suggests that the remaining normal allele is required for the phenotype. Second, it suggests therapeutic approaches to treatment signal transduction inhibition.
January 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28005008/angiopoietin-receptor-tie2-is-required-for-vein-specification-and-maintenance-via-regulating-coup-tfii
#11
Man Chu, Taotao Li, Bin Shen, Xudong Cao, Haoyu Zhong, Luqing Zhang, Fei Zhou, Wenjuan Ma, Haijuan Jiang, Pancheng Xie, Zhengzheng Liu, Ningzheng Dong, Ying Xu, Yun Zhao, Guoqiang Xu, Peirong Lu, Jincai Luo, Qingyu Wu, Kari Alitalo, Gou Young Koh, Ralf H Adams, Yulong He
Mechanisms underlying the vein development remain largely unknown. Tie2 signaling mediates endothelial cell (EC) survival and vascular maturation and its activating mutations are linked to venous malformations. Here we show that vein formation are disrupted in mouse skin and mesentery when Tie2 signals are diminished by targeted deletion of Tek either ubiquitously or specifically in embryonic ECs. Postnatal Tie2 attenuation resulted in the degeneration of newly formed veins followed by the formation of haemangioma-like vascular tufts in retina and venous tortuosity...
December 22, 2016: ELife
https://www.readbyqxmd.com/read/27909461/savanna-burning-methodology-for-fire-management-and-emissions-reduction-a-critical-review-of-influencing-factors
#12
REVIEW
Tek Narayan Maraseni, Kathryn Reardon-Smith, Greg Griffiths, Armando Apan
Savanna fire is a major source of global greenhouse gas (GHG) emissions. In Australia, savanna fire contributes about 3% of annual GHG emissions reportable to the Kyoto Protocol. In order to reduce GHG emissions from savanna burning, the Australian government has developed and approved a Kyoto compliant savanna controlled burning methodology-the first legal instrument of this kind at a global level-under its Emission Reduction Fund. However, this approved methodology is currently only applicable to nine vegetation fuel types across northern parts of Australia in areas which receive on average over 600 mm rainfall annually, covering only 15...
December 2016: Carbon Balance and Management
https://www.readbyqxmd.com/read/27881142/ethnoagroforestry-integration-of-biocultural-diversity-for-food-sovereignty-in-mexico
#13
Ana Isabel Moreno-Calles, Alejandro Casas, Alexis Daniela Rivero-Romero, Yessica Angélica Romero-Bautista, Selene Rangel-Landa, Roberto Alexander Fisher-Ortíz, Fernando Alvarado-Ramos, Mariana Vallejo-Ramos, Dídac Santos-Fita
BACKGROUND: Documenting the spectrum of ecosystem management, the roles of forestry and agricultural biodiversity, TEK, and human culture for food sovereignty, are all priority challenges for contemporary science and society. Ethnoagroforestry is a research approach that provides a theoretical framework integrating socio-ecological disciplines and TEK. We analyze in this study general types of Agroforestry Systems of México, in which peasants, small agriculturalist, and indigenous people are the main drivers of AFS and planning of landscape diversity use...
November 23, 2016: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/27876862/in-silico-exploration-for-novel-type-i-inhibitors-of-tie-2-tek-the-performance-of-different-selection-strategy-in-selecting-virtual-screening-candidates
#14
Peichen Pan, Huiyong Sun, Hui Liu, Dan Li, Wenfang Zhou, Xiaotian Kong, Youyong Li, Huidong Yu, Tingjun Hou
The receptor tyrosine kinase Tie-2 is involved in vessel remodeling and maturation, and has been regarded as a potential target for the treatment of various solid tumors. The absence of novel, potent and selective inhibitors severely hampers the understanding of the therapeutic potential of Tie-2. In the present work, we describe the discovery of novel type-I inhibitors of Tie-2 by structure-based virtual screening. Preliminary SAR was also performed based on one active compound, and several novel inhibitors with low micro-molar affinity were discovered...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876390/landscape-changes-traditional-ecological-knowledge-and-future-scenarios-in-the-alps-a-holistic-ecological-approach
#15
Clara Tattoni, Elena Ianni, Davide Geneletti, Paolo Zatelli, Marco Ciolli
In recent decades, a dramatic landscape change has occurred in the European alpine region: open areas have been naturally recolonized by forests as traditional agricultural and forest activities were reduced and reorganized. Land use changes (LUC) are generally measured through GIS and photo interpretation techniques, but despite many studies focused on this phenomenon and its effects on biodiversity and on the environment in general, there is a lack of information about the transformation of the human-environment connection...
February 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/27866660/graft-copolymerization-of-acrylamide-on-chitosan-co-chitin-and-its-application-for-immobilization-of-aspergillus-sp-rl2ct-cutinase
#16
Vijaya Kumari, Sandeep Kumar, Inderjeet Kaur, Tek Chand Bhalla
The synthesis of chitosan (Chs) and chitin (Chi) copolymer and grafting of acrylamide (AAm) onto the synthesized copolymer have been carried out by chemical methods. The grafted copolymer was characterized by FTIR, SEM and XRD. The extracellular cutinase of Aspergillus sp. RL2Ct (E.C. 3.1.1.3) was purified to 4.46 fold with 16.1% yield using acetone precipitation and DEAE sepharose ion exchange chromatography. It was immobilized by adsorption on the grafted copolymer. The immobilized enzyme was found to be more stable then the free enzyme and has a good binding efficiency (78...
November 12, 2016: Bioorganic Chemistry
https://www.readbyqxmd.com/read/27843154/the-nf-%C3%AE%C2%BAb-signaling-pathway-an-important-therapeutic-target-in-psychiatric-disorders
#17
M A Altinoz, B Ince, C Tek, V H Srihari, S Guloksuz
No abstract text is available yet for this article.
November 15, 2016: Molecular Psychiatry
https://www.readbyqxmd.com/read/27815943/religious-exception-for-vaccination-or-religious-excuses-for-avoiding-vaccination
#18
Gordana Pelčić, Silvana Karačić, Galina L Mikirtichan, Olga I/ Kubar, Frank J Leavitt, Michael Cheng-Tek Tai, Naoki Morishita, Suzana Vuletić, Luka Tomašević
No abstract text is available yet for this article.
October 31, 2016: Croatian Medical Journal
https://www.readbyqxmd.com/read/27800035/oncogene-knockdown-via-active-loading-of-small-rnas-into-extracellular-vesicles-by-sonication
#19
Tek N Lamichhane, Anjana Jeyaram, Divya B Patel, Babita Parajuli, Natalie K Livingston, Navein Arumugasaamy, John S Schardt, Steven M Jay
Extracellular vesicles (EVs), including exosomes and microvesicles, have emerged as promising drug delivery vehicles for small RNAs (siRNA and miRNA) due to their natural role in intercellular RNA transport. However, the application of EVs for therapeutic RNA delivery may be limited by loading approaches that can induce cargo aggregation or degradation. Here, we report the use of sonication as a means to actively load functional small RNAs into EVs. Conditions under which EVs could be loaded with small RNAs with minimal detectable aggregation were identified, and EVs loaded with therapeutic siRNA via sonication were observed to be taken up by recipient cells and capable of target mRNA knockdown leading to reduced protein expression...
September 2016: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/27771357/a-pseudo-random-patient-sampling-method-evaluated
#20
Nicole L De La Mata, Mi-Young Ahn, Nagalingeswaran Kumarasamy, Penh Sun Ly, Oon Tek Ng, Kinh Van Nguyen, Tuti Parwati Merati, Thuy Thanh Pham, Man Po Lee, Nicolas Durier, Matthew G Law
OBJECTIVE: To compare two HIV cohorts to determine whether a pseudo-random sample can represent the entire study population. STUDY DESIGN AND SETTING: HIV-positive patients receiving care at 8 sites in 7 Asian countries. TAHOD pseudo-randomly selected a patient sample, while TAHOD-LITE included all patients. We compared patient demographics, CD4 count and HIV viral load testing for each cohort. Risk factors associated with CD4 count response, HIV viral load suppression (<400 copies/mL) and survival were determined for each cohort...
October 19, 2016: Journal of Clinical Epidemiology
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