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https://www.readbyqxmd.com/read/29305979/target-gene-screening-and-evaluation-of-prognostic-values-in-non-small-cell-lung-cancers-by-bioinformatics-analysis
#1
Junjie Piao, Jie Sun, Yang Yang, Tiefeng Jin, Liyan Chen, Zhenhua Lin
BACKGROUND: Non-small cell lung cancer (NSCLC) is the major leading cause of cancer-related deaths worldwide. This study aims to explore molecular mechanism of NSCLC. METHODS: Microarray dataset was obtained from the Gene Expression Omnibus (GEO) database, and analyzed by using GEO2R. Functional and pathway enrichment analysis were performed based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) database. Then, STRING, Cytoscape and MCODE were applied to construct the Protein-protein interaction (PPI) network and screen hub genes...
January 3, 2018: Gene
https://www.readbyqxmd.com/read/29301108/mesenchymal-stromal-cells-inhibit-inflammatory-lymphangiogenesis-in-the-cornea-by-suppressing-macrophage-in-a-tsg-6-dependent-manner
#2
Hyun Beom Song, Se Yeon Park, Jung Hwa Ko, Jong Woo Park, Chang Ho Yoon, Dong Hyun Kim, Jeong Hun Kim, Mee Kum Kim, Ryang Hwa Lee, Darwin J Prockop, Joo Youn Oh
The cornea is a transparent tissue devoid of blood and lymphatic vessels. However, various inflammatory conditions can cause hemangiogenesis and lymphangiogenesis in the cornea, compromising transparency and visual acuity. Mesenchymal stem/stromal cells (MSCs) have therapeutic potentials in a variety of diseases because of anti-inflammatory properties. Herein, we investigated the effects of MSCs on corneal angiogenesis using a model of suture-induced inflammatory corneal neovascularization. Data demonstrated that an intravenous administration of MSCs suppressed corneal inflammation and neovascularization, inhibiting both hemangiogenesis and lymphangiogenesis...
January 3, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29258623/dynamic-modeling-of-folliculogenesis-signaling-pathways-in-the-presence-of-mirnas-expression
#3
Abolfazl Bahrami, Seyed Reza Miraie-Ashtiani, Mostafa Sadeghi, Ali Najafi, Reza Ranjbar
BACKGROUND: TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differentiation, migration, adhesion, proliferation, survival and protein synthesis. RESULTS: TEK signaling on each of the two important pathways where levels of pERK, pMYC, pAkt, pMCL1 and pEIF4EBP1 are increased in dominant follicles and pMYC is decreased in dominant follicles...
December 19, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29243388/the-treatment-outcomes-of-antiretroviral-substitutions-in-routine-clinical-settings-in-asia-data-from-the-treat-asia-hiv-observational-database-tahod
#4
In Young Jung, David Boettiger, Wing Wai Wong, Man Po Lee, Sasisopin Kiertiburanakul, Romanee Chaiwarith, Anchalee Avihingsanon, Junko Tanuma, Nagalingeswaran Kumarasamy, Adeeba Kamarulzaman, Fujie Zhang, Pacharee Kantipong, Oon Tek Ng, Benedict Lim Heng Sim, Matthew Law, Jeremy Ross, Jun Yong Choi
INTRODUCTION: Although substitutions of antiretroviral regimen are generally safe, most data on substitutions are based on results from clinical trials. The objective of this study was to evaluate the treatment outcomes of substituting antiretroviral regimen in virologically suppressed HIV-infected patients in non-clinical trial settings in Asian countries. METHODS: The study population consisted of HIV-infected patients enrolled in the TREAT Asia HIV Observational Database (TAHOD)...
December 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29242863/cyclic-amino-carboranyl-silylene-synthesis-structure-and-reactivity
#5
Hao Wang, Tek Long Chan, Zuowei Xie
A carbene-stabilized cyclic amino(carboranyl) silylene has been prepared from the reaction of cyclic amino(carboranyl) chlorosilane with N-heterocyclic carbene via HCl elimination. Its structure has been characterized by single-crystal X-ray analysis and DFT calculations. It is a very strong σ donor and relatively poor π acceptor. It can form a Lewis acid-base adduct with borane and undergo cycloaddition reactions with unsaturated molecules such as diphenylacetylene and benzophenone.
December 15, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29237785/mcr-3-and-mcr-4-variants-in-carbapenemase-producing-clinical-enterobacteriaceae-do-not-confer-phenotypic-polymyxin-resistance
#6
Jeanette W P Teo, Marimuthu Kalisvar, Indumathi Venkatachalam, Ng Oon Tek, Raymond T P Lin, Sophie Octavia
The world-wide distribution of plasmid-mediated colistin resistance determinants (mcr-1, mcr-2, mcr-3 and mcr-4) coupled to an emerging observation that colistin resistance is more prevalent in carbapenem-resistant Enterobacteriaceae (CRE) (1, 2) present a daunting challenge in combatting antimicrobial resistance. Undoubtedly, next-generation sequencing approaches have expedited the discovery of mobile colistin resistance determinants (3).….
December 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29178772/antimicrobial-action-and-long-term-effect-of-overnight-denture-cleansers
#7
Amanda Peracini, Ingrid Machado Andrade, Viviane Cássia Oliveira, Ana Paula Macedo, Claudia Helena Silva-Lovato, Valéria Oliveira Pagnano, Evandro Watanabe, Helena de Freitas Oliveira Paranhos
PURPOSE: To evaluate two denture cleansers for overnight soaking (0.5% sodium hypochlorite and peroxide alkaline) regarding efficacy against Candida spp. biofilms (randomized clinical trial) and their effects on the physical properties of a denture base acrylic resin simulating a period of 5 years of use (laboratory study). The Candida spp. were identified and their resistance to main antifungal agents was evaluated. METHODS: 32 complete denture wearers were instructed to brush their dentures three times a day and to soak them (≥8 hours) in: control - water (C); alkaline peroxide (AP); or 0...
April 2017: American Journal of Dentistry
https://www.readbyqxmd.com/read/29178246/effects-of-the-antagomirs-15b-and-200b-on-the-altered-healing-pattern-of-diabetic-mice
#8
Gabriele Pizzino, Natasha Irrera, Federica Galfo, Giovanni Pallio, Federica Mannino, Angelica D'amore, Enrica Pellegrino, Antonio Ieni, Giuseppina T Russo, Marco Calapai, Domenica Altavilla, Francesco Squadrito, Alessandra Bitto
BACKGROUND AND PURPOSE: Diabetic subjects with non-healing ulcers have a reduced expression of vascular endothelial growth factor (VEGF). Genetically diabetic mice have an altered expression pattern of VEGF and its receptor, VEGFR-2. In diabetic wounds, miR15b and miR200b which respectively inhibit VEGF and VEGF-R2 mRNAs are up-regulated, further affecting the impaired angiogenesis. We investigated whether anti-miRs directed toward miR15b and miR200b could improve wound repair in genetically diabetic mice...
November 26, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29176788/preservation-of-three-dimensional-spatial-structure-in-the-gut-microbiome
#9
Yuko Hasegawa, Jessica L Mark Welch, Blair J Rossetti, Gary G Borisy
Preservation of three-dimensional structure in the gut is necessary in order to analyze the spatial organization of the gut microbiota and gut luminal contents. In this study, we evaluated preparation methods for mouse gut with the goal of preserving micron-scale spatial structure while performing fluorescence imaging assays. Our evaluation of embedding methods showed that commonly used media such as Tissue-Tek Optimal Cutting Temperature (OCT) compound, paraffin, and polyester waxes resulted in redistribution of luminal contents...
2017: PloS One
https://www.readbyqxmd.com/read/29159696/reflex-testing-of-speckled-cytoplasmic-patterns-observed-in-routine-ana-hep-2-indirect-immunofluorescence-with-a-multiplex-anti-synthetase-dot-blot-assay-a-multicentric-pilot-study
#10
Maria Infantino, Boaz Palterer, Roberta Biagiotti, Fabio Almerigogna, Maurizio Benucci, Arianna Damiani, Valentina Grossi, Annalisa Azzurri, Patrizia Casprini, Giovanni Bacci, Maria Grazia Giudizi, Mariangela Manfredi
Immunofluorescence on HEp2-cells is the standard diagnostic assay for the detection of anti-nuclear antibodies (ANA). Cytoplasmic speckled patterns are a common finding, and are associated with various antibodies, including anti-synthetase antibodies. However, classic ENA testing generally identifies only anti-Jo-1. Moreover, anti-synthetase syndrome is increasingly recognized as a pleomorphic entity, possibly presenting as isolated arthritis or interstitial lung disease. Sera referred for routine ANA testing were selected on the basis of the presence of a fine dense speckled cytoplasmic pattern (254 samples) and compared to control sera with negative cytoplasm (239 samples)...
November 21, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29156862/the-prevalence-of-abdominal-obesity-is-remarkable-for-underweight-and-normal-weight-adolescent-girls
#11
Nilüfer Acar Tek, Nevin Şanlıer, Duygu Türközü
Background/aim: Obesity is a global public health challenge. This study was carried out in order to determine the prevalence of obesity and abdominal obesity in Turkish adolescent girls. Materials and methods: A cross-sectional study was conducted in a total of 1111 adolescent girls aged 12?18 years. The subjects were classified into four groups: underweight, normal, overweight, and obese. Abdominal obesity was defined according to waist circumference (WC) ≥ 90th percentile for Turkish adolescent population references (12-17 years) and waist-to-height ratio (WHtR) ≥ 0...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29142882/incidence-of-apical-crack-formation-and-propagation-during-removal-of-root-canal-filling-materials-with-different-engine-driven-nickel-titanium-instruments
#12
Taha Özyürek, Vildan Tek, Koray Yılmaz, Gülşah Uslu
Objectives: To determine the incidence of crack formation and propagation in apical root dentin after retreatment procedures performed using ProTaper Universal Retreatment (PTR), Mtwo-R, ProTaper Next (PTN), and Twisted File Adaptive (TFA) systems. Materials and Methods: The study consisted of 120 extracted mandibular premolars. One millimeter from the apex of each tooth was ground perpendicular to the long axis of the tooth, and the apical surface was polished...
November 2017: Restorative Dentistry & Endodontics
https://www.readbyqxmd.com/read/29106382/angiopoietin-1-is-required-for-schlemm-s-canal-development-in-mice-and-humans
#13
Benjamin R Thomson, Tomokazu Souma, Stuart W Tompson, Tuncer Onay, Krishnakumar Kizhatil, Owen M Siggs, Liang Feng, Kristina N Whisenhunt, Tammy L Yanovitch, Luba Kalaydjieva, Dimitar N Azmanov, Simone Finzi, Christine E Tanna, Alex W Hewitt, David A Mackey, Yasmin S Bradfield, Emmanuelle Souzeau, Shari Javadiyan, Janey L Wiggs, Francesca Pasutto, Xiaorong Liu, Simon Wm John, Jamie E Craig, Jing Jin, Terri L Young, Susan E Quaggin
Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. Here, we describe roles for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure...
November 6, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29104145/the-dual-effects-of-a-novel-peptibody-on-angiogenesis-inhibition-and-m2-macrophage-polarization-on-sarcoma
#14
Xiaoqing Zhu, Jiali Yang, Yanfeng Gao, Chunjing Wu, Lili Yi, Guodong Li, Yuanming Qi
Inhibition of the VEGF/VEGF receptor (VEGFR) and angiopoietin-2 (Ang-2)/TEK receptor tyrosine kinase (Tie-2) pathway is a potential target for tumor angiogenesis. We previously showed that a peptide AS16 which dually inhibits VEGFR/Ang-2 could reduce the tumor growth and decrease the number of microvessels in tumor. However, its short circulating half-life in the serum limits its clinical applications. In this study, as an effort to prolong the short in vivo half-life of AS16, we designed a fusion protein containing peptide AS16 and an IgG Fc fragment...
November 2, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29062004/ethanol-induces-enhanced-vascularization-bioactivity-of-endothelial-cell-derived-extracellular-vesicles-via-regulation-of-micrornas-and-long-non-coding-rnas
#15
Tek N Lamichhane, Christopher A Leung, Lampouguin Yenkoidiok Douti, Steven M Jay
Extracellular vesicles (EVs), such as exosomes, have been identified as regulators of vascular remodeling and have promise as therapeutics for vascularization applications. Towards development of EVs as therapeutics, it has been demonstrated that physiological stimuli of angiogenic phenotypes in EV-producing cells can enhance the potency of EVs for vascularization. The goal of this study was to assess whether ethanol, which induces angiogenic phenotypes in endothelial cells, could be employed to enhance endothelial-derived EV vascularization bioactivity...
October 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29034511/computationally-efficient-combination-of-multi-channel-phase-data-from-multi-echo-acquisitions-aspire
#16
Korbinian Eckstein, Barbara Dymerska, Beata Bachrata, Wolfgang Bogner, Karin Poljanc, Siegfried Trattnig, Simon Daniel Robinson
PURPOSE: To develop a simple method for combining multi-echo phase information from a number of coils in an array that requires no volume coil or additional scans and yields signal-to-noise ratio-optimal images that reflect only ΔB0-related phase. THEORY AND METHODS: Two SNR optimal coil combination methods were developed which retrieve the ΔB0-related phase by determining the coil-dependent phase offsets. The first variant, MCPC-3D-S, requires the unwrapping of one phase image; the second variant, ASPIRE, allows unwrapping to be avoided if two echoes j and k satisfy the echo time relation m⋅TEk=(m+1)⋅TEj, where m is an integer, making this a particularly fast and robust approach...
October 16, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29027430/-virtual-screening-of-anti-angiogenesis-flavonoids-from-sophora-flavescens
#17
Xi-Xin Chen, Yi Liu, Rong Huang, Lin-Lin Zhao, Lei Chen, Shu-Mei Wang
Angiogenesis is a dynamic, multi-step process. It is known that about 70 diseases are related to angiogenesis. Both the experimental and the literature reports showed that Sophora flavescens inhibit angiogenesis significantly, but the material basis and the mechanism of action have not been clear. In this study, molecular docking was used for screening of anti-angiogenesis flavonoids from the roots of S. flavescens. One handred and twenty-six flavonoids selected from S. flavescens were screened in the docking ligand database with six targets(VEGF-a,TEK,KDR,Flt1,FGFR1 and FGFR2) as the receptors...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29020646/hiv-1-subtype-crf01_ae-and-b-differ-in-utilization-of-low-levels-of-ccr5-maraviroc-susceptibility-and-potential-n-glycosylation-sites
#18
Anjali Joshi, Emily K Cox, Melina J Sedano, Erin B Punke, Raphael Tc Lee, Sebastian Maurer-Stroh, Palvinder Kaur, Oon Tek Ng, Himanshu Garg
HIV subtypes not only predominate in different geographical regions but also differ in key phenotypic characteristics. To determine if genotypic and/or phenotypic differences in the Envelope (Env) glycoprotein can explain subtype related differences, we cloned 37 full length Envs from Subtype B and AE HIV infected individuals from Singapore. Our data demonstrates that CRF01_AE Envs have lower Potential N Glycosylation Sites and higher risk of ×4 development. Phenotypically, CRF01_AE were less infectious than subtype B Envs in cells expressing low levels of CCR5...
December 2017: Virology
https://www.readbyqxmd.com/read/28961876/health-assessments-for-health-governance-concepts-and-methodologies
#19
Rainer Fehr, Kristina Alexanderson, Carlo Favaretti, Judith de Jong, Giuseppe La Torre, Tek-Ang Lim, Piedad Martin-Olmedo, Odile C L Mekel, Kai Michelsen, Nicole Rosenkötter, Marieke Verschuuren, Chiara de Waure, Dineke Zeegers Paget
Background: For better supporting the science-governance interface, the potential of health assessments appears underrated. Aims: To identify what various types of health assessment have in common; how they differ; which assessment(s) to apply for which purpose; and what needs and options there are for future joint development. Methods: This review is based on five types of health assessment: monitoring/surveillance/reporting, assessment of health impact, of health technology, of health systems performance, health-related economic assessment...
August 1, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28959114/reply-to-the-letter-to-the-editor-for-the-article-entitled-epicardial-adiposity-is-associated-with-microalbuminuria-in-patients-with-essential-hypertension-published-in-the-journal-of-acta-cardiologica-sinica-in-2017-2017-33-74-80
#20
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