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Paola Queirolo, Francesco Spagnolo, Virginia Picasso, Laura Spano, Enrica Tanda, Valeria Fontana, Laura Giorello, Domenico Franco Merlo, Ester Simeone, Antonio Maria Grimaldi, Marcello Curvietto, Michele Del Vecchio, Paolo Bruzzi, Paolo Antonio Ascierto
Background: BRAF inhibitor vemurafenib achieves high response rate and an improvement in survival in patients with BRAF-mutated metastatic melanoma. However, median progression-free survival is only 6.9 months in the phase 3 study. Retrospective analyses suggest that treatment with BRAF inhibitors beyond initial progression might be associated with improved overall survival. We aimed to prospectively investigate the activity of prolonged treatment with vemurafenib and the addition of fotemustine in patients with systemic progression on prior single-agent BRAF inhibitor...
February 23, 2018: Oncotarget
Lamiae Grimaldi-Bensouda, Nicolas Danchin, Jean Dallongeville, Bruno Falissard, Alain Furber, Yves Cottin, Laurent Bonello, Olivier Morel, Florence Leclercq, Etienne Puymirat, Fahmi Ghanem, Nicolas Delarche, Jacques Benichou, Lucien Abenhaim
OBJECTIVE: To compare ticagrelor and prasugrel with clopidogrel for recurrent fatal and non-fatal myocardial infarction (reMI) in real-life conditions. METHODS: Case-referent study using the Pharmacoepidemiological General Research eXtension (PGRx)-acute coronary syndrome (ACS) registry. Cases were patients with reMI from a cohort with index ACS or external to the cohort (same sites). Referents from the cohort, without recurrent event, were matched on index ACS type and date, age and sex with reMI cases...
March 13, 2018: Heart: Official Journal of the British Cardiac Society
Phealay May, Patricia Bremond, Christophe Sauzet, Philippe Piccerelle, Frédérique Grimaldi, Serge Champion, Pierre-Henri Villard
(1) Objective: Highlight the in vitro effects of 3T3-L1 cell exposure to polychlorinated biphenyls (PCB118 and 153) or benzo(a)pyrene (BaP) alone or as a cocktail on adipogenesis (ADG) by focusing on changes in lipid metabolism and inflammatory-related genes expression (INFG) and ADG-related genes expression (ADGG); (2) Results: Treatment from the early stage of cell differentiation by BaP alone or in combination with PCBs decreased the expression of some of the ADGG ( PPARγ Glut-4 , FAS , Lipin-1a , Leptin , and Adiponectin )...
March 13, 2018: International Journal of Molecular Sciences
Jason R Carter, Daniela Grimaldi, Ida T Fonkoue, Lisa Medalie, Babak Mokhlesi, Eve Van Cauter
Study Objectives: Chronic insomnia affects up to 15% of adults. Recent cross-sectional and prospective epidemiological studies report an association between insomnia and hypertension, including incident hypertension, yet mechanisms underlying the association remain unknown. We hypothesized that subjects with chronic insomnia would have elevated sympathetic neural outflow, blunted baroreflex sensitivity, and augmented sympathetic neural and cardiovascular reactivity to stress when compared to good-sleeper controls...
March 7, 2018: Sleep
Gaia Grimaldi, Antonio Leo, Angela Nigro, Sandro Pace, Valeria Braccini, Emilio Bellingeri, Carlo Ferdeghini
Anisotropy effects on flux pinning and flux flow are strongly effective in cuprate as well as iron-based superconductors due to their intrinsically layered crystallographic structure. However Fe(Se,Te) thin films grown on CaF2 substrate result less anisotropic with respect to all the other iron based superconductors. We present the first study on the angular dependence of the flux flow instability, which occurs in the flux flow regime as a current driven transition to the normal state at the instability point (I*, V*) in the current-voltage characteristics...
March 7, 2018: Scientific Reports
Ewan Couic, Michel Grimaldi, Vanessa Alphonse, Clarisse Balland-Bolou-Bi, Alexandre Livet, Stéphanie Giusti-Miller, Max Sarrazin, Noureddine Bousserrhine
Several decades of gold mining extraction activities in the Amazonian rainforest have caused deforestation and pollution. While ecological rehabilitation is essential for restoring biodiversity and decreasing erosion on deforested lands, few studies note the behaviour or toxicity of trace elements during the rehabilitation process. Our original study focused on the potential use of microbial activity and Hg speciation and compared them with As, Cu, Zn and Cr speciation in assessing the chemical and biological quality of ecological restoration efforts...
March 5, 2018: Environmental Science. Processes & Impacts
A Zullo, E Simone, M Grimaldi, M Gagliardi, L Zullo, M R Matarazzo, F P Mancini
BACKGROUND AND AIM: Over the last decades advances in understanding the molecular bases of the close relationship between nutrition, metabolism, and diseases have been impressive. However, there are always novel frontiers coming up and epigenetics is one of these. Sirtuins, are pivotal factors in the control of metabolic pathways according to nutrient availability. In the present study we evaluated the effect of nutrient deprivation on expression, DNA methylation and chromatin status of the sirtuin genes...
February 13, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Le Clec'h Solen, Jégou Nicolas, Arnauld de Sartre Xavier, Decaens Thibaud, Dufour Simon, Grimaldi Michel, Oszwald Johan
In tropical forests farmers are among the most important agents of deforestation. At the interface between societies and their environment, ecosystem services (ES) is an integrated working framework through which natural and anthropogenic dimensions can be addressed. Here, we aimed to understand to what extent farmers impact ES availability. Based on case studies in three locations in the Brazilian Amazon rainforest, we performed statistical analyses at 135 sampling points and 110 farms to link socioeconomic and ES data, both derived from field work...
March 1, 2018: Environmental Management
Maria Carmela Grimaldi, Chiara Trentin, Roberto Lo Gullo, Enrico Cassano
Breast fibromatosis, also referred to as desmoid tumor or aggressive fibromatosis, is a very rare, locally aggressive disease that does not metastasize. Bilateral lesions are extremely rare and are found in only 4% of patients with breast fibromatosis. Tumor recurrence following surgery occurs in 18%-29% of patients, most often within the first 2 years after surgery. In this report, we discuss a case of breast fibromatosis, mimicking a breast carcinoma both clinically and radiologically, that presented clinically with dimpling of the skin of the left breast in a 31-year-old woman...
February 2018: Radiology Case Reports
Marie-Anne Loriot, Joseph Ciccolini, Fabienne Thomas, Chantal Barin-Le-Guellec, Bernard Royer, Gérard Milano, Nicolas Picard, Laurent Becquemont, Céline Verstuyft, Céline Narjoz, Antonin Schmitt, Christine Bobin-Dubigeon, Alexandre Harle, Angelo Paci, Vianney Poinsignon, Sylvie Quaranta, Alexandre Evrard, Benjamin Hennart, Franck Broly, Xavier Fonrose, Claire Lafay-Chebassier, Anne-Sophie Wozny, Fadil Masskouri, Jean-Christophe Boyer, Marie-Christine Etienne-Grimaldi
Fluoropyrimidines (FU) are still the most prescribed anticancer drugs for the treatment of solid cancers. However, fluoropyrimidines cause severe toxicities in 10 to 40% of patients and toxic deaths in 0.2 to 0.8% of patients, resulting in a real public health problem. The main origin of FU-related toxicities is a deficiency of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme of 5-FU catabolism. DPD deficiency may be identified through pharmacogenetics testing including phenotyping (direct or indirect measurement of enzyme activity) or genotyping (detection of inactivating polymorphisms on the DPYD gene)...
February 24, 2018: Bulletin du Cancer
Kim Allison, Michelle Hall, Paul W Hodges, Tim V Wrigley, Bill Vicenzino, Yong-Hao Pua, Ben Metcalf, Alison Grimaldi, Kim L Bennell
BACKGROUND: Gluteal tendinopathy (GT) and hip osteoarthritis (OA) are the most common causes of hip pain and associated disability in older adults. Pain and altered walking biomechanics are common to both conditions. This study aimed to compare three-dimensional walking biomechanics between individuals with unilateral, symptomatic GT and HOA. METHODS: Sixty individuals with symptomatic unilateral GT confirmed by magnetic-resonance-imaging and 73 individuals with symptomatic unilateral HOA (Kellgren-Lawrence Grade ≥ 2) underwent three-dimensional gait analysis...
February 12, 2018: Gait & Posture
Priya K Shah, Ilana A Kafer, Gregory M Grimaldi
OBJECTIVE: The objective of this study was to determine the rate of malignancy in incidentally detected T2 hyperintense hepatic lesions at breast MRI. METHODS: Incidental hepatic lesions identified during breast MRI, for which abdominal imaging was recommended, were retrospectively analyzed. RESULTS: Of the hepatic lesions, 97.3% were benign, and 2.7% were malignant, with a significant association between indication for the breast MRI and the malignancy status of the hepatic lesion (Fisher's Exact, P < 0...
February 6, 2018: Clinical Imaging
David Merschin, Lisa Wenzel, Valeska Hofmann, Anna Katharina Doepfer, Manuel Mutschler, Jan Philipp Schüttrumpf, Gina Grimaldi
No abstract text is available yet for this article.
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
Aurora Montali, Morena Casartelli, Daniele Bruno, Annalisa Grimaldi, Gianluca Tettamanti
In holometabolous insects, various larval organs are remodeled by autophagy during metamorphosis. Although moths and butterflies are among the first animal models in which this self-eating process was described, only in recent years autophagy has been analyzed in detail in these insects. In particular, the silkworm Bombyx mori, which represents a well-studied model among Lepidoptera, provides a wide repertoire of cellular and molecular tools useful for studying the occurrence of autophagy and for evaluating its role in postembryonic development...
February 15, 2018: Methods in Molecular Biology
Raúl Domínguez, Antonio Jesús Sánchez-Oliver, Fernando Mata-Ordoñez, Adrián Feria-Madueño, Moisés Grimaldi-Puyana, Álvaro López-Samanes, Alberto Pérez-López
Iron deficiency is a frequent and multifactorial disorder in the career of athletes, particularly in females. Exercise-induced disturbances in iron homeostasis produce deleterious effects on performance and adaptation to training; thus, the identification of strategies that restore or maintain iron homeostasis in athletes is required. Hepcidin is a liver-derived hormone that degrades the ferroportin transport channel, thus reducing the ability of macrophages to recycle damaged iron, and decreasing iron availability...
February 14, 2018: Nutrients
Chiara Eberspacher, D Mascagni, L Fralleone, G Grimaldi, P Antypas, P Mascagni, A Maturo, F M Di Matteo, S Pontone, D Pironi
AIM: Anal fistula is a common disease originated from abscess according the cryptoglandular theory. A rare etiology is the pilonidal disease. In our case we observed a pilonidal disease mimicking an anterior perianal fistula, associated with another posterior anal fistula. CASE PRESENTATION: A 36-year old man was referred to our department with an anal fistula with an anterior opening. Despite the clinical examination and the endoanal ultrasound, only during the surgery we discovered the origin of the anterior fistula from a misdiagnosed pilonidal sinus...
November 2017: Il Giornale di Chirurgia
G Grimaldi, Chiara Eberspacher, A M Romani, D Merletti, A Maturo, S Pontone, D Pironi
AIM: The incidence of rectal cancer continues to rise. The functional results after complete Total Mesorectal Excision (TME) depend on the segment of colon used for reconstruction of colonic continuity and the form, the volume and the functional proprieties of the "neorectum". The aim of our study is evaluate the efficacy of our Modified Transverse Coloplasty Pouch (MTCP) after the treatment of low rectal cancer in terms of functional outcomes and quality of life. PATIENTS AND METHODS: The study included 136 patients, underwent TME from January 2007 to December 2016 with diagnosis of extraperitoneal carcinoma of the rectum...
November 2017: Il Giornale di Chirurgia
Luca Tagliaferri, Monica Maria Pagliara, Carlotta Masciocchi, Andrea Scupola, Luigi Azario, Gabriela Grimaldi, Rosa Autorino, Maria Antonietta Gambacorta, Antonio Laricchiuta, Luca Boldrini, Vincenzo Valentini, Maria Antonietta Blasi
Purpose: To develop a predictive model and nomogram for maculopathy occurrence at 3 years after 106 Ru/ 106 Rh plaque brachytherapy in uveal melanoma. Material and methods: Clinical records of patients affected by choroidal melanoma and treated with 106 Ru/ 106 Rh plaque from December 2006 to December 2014 were retrospectively reviewed. Inclusion criteria were: dome-shaped melanoma, distance to the fovea > 1.5 mm, tumor thickness > 2 mm, and follow-up > 4 months...
December 2017: Journal of Contemporary Brachytherapy
Biancamaria Aranguren, Anna Revedin, Nicola Amico, Fabio Cavulli, Gianna Giachi, Stefano Grimaldi, Nicola Macchioni, Fabio Santaniello
Excavations for the construction of thermal pools at Poggetti Vecchi (Grosseto, Tuscany, central Italy) exposed a series of wooden tools in an open-air stratified site referable to late Middle Pleistocene. The wooden artifacts were uncovered, together with stone tools and fossil bones, largely belonging to the straight-tusked elephant Paleoloxodon antiquus The site is radiometrically dated to around 171,000 y B.P., and hence correlated with the early marine isotope stage 6 [Benvenuti M, et al. (2017) Quat Res 88:327-344]...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
M L Plinsinga, B K Coombes, R Mellor, P Nicolson, A Grimaldi, P Hodges, K Bennell, B Vicenzino
BACKGROUND: Gluteal tendinopathy is the most common lower limb tendinopathy presenting to general practice. It has a high prevalence among middle-aged females and impacts on daily activities, work participation and quality of life. The aim was to compare physical and psychological characteristics between subgroups of severity of pain and disability. METHODS: A multi-centre cross-sectional cohort of 204 participants (mean age 55 years, 82% female) who had a clinical diagnosis of gluteal tendinopathy with MRI confirmation were assessed...
February 9, 2018: European Journal of Pain: EJP
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