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Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#2
JOURNAL ARTICLE
Leonardo De Luca, Stefania Angela Di Fusco, Gianmarco Iannopollo, Raffaella Mistrulli, Vittoria Rizzello, Alberto Aimo, Alessandro Navazio, Claudio Bilato, Marco Corda, Massimo Di Marco, Giovanna Geraci, Attilio Iacovoni, Massimo Milli, Vittorio Pascale, Carmine Riccio, Pietro Scicchitano, Emanuele Tizzani, Domenico Gabrielli, Massimo Grimaldi, Furio Colivicchi, Fabrizio Oliva
The issue of suboptimal drug regimen adherence in secondary cardiovascular prevention presents a significant barrier to improving patient outcomes. To address this, the utilization of drug combinations, specifically single pill combinations (SPCs) and polypills, was proposed as a strategy to simplify treatment regimens. This approach aims to enhance treatment accessibility, affordability, and adherence, thereby reducing healthcare costs and improving patient health. The document is an ANMCO scientific statement on simplifying drug regimens for secondary cardiovascular prevention...
May 2024: Giornale Italiano di Cardiologia
#3
JOURNAL ARTICLE
Stefania Angela Di Fusco, Edoardo Mocini, Mauro Gori, Massimo Iacoviello, Claudio Bilato, Marco Corda, Leonardo De Luca, Massimo Di Marco, Giovanna Geraci, Attilio Iacovoni, Massimo Milli, Alessandro Navazio, Vittorio Pascale, Carmine Riccio, Pietro Scicchitano, Emanuele Tizzani, Domenico Gabrielli, Massimo Grimaldi, Furio Colivicchi, Fabrizio Oliva
Obesity is a chronic and relapsing disease due to the coexistence of a patient with predisposing individual characteristics and an obesogenic environment. The recent acquisition of detailed knowledge on the mechanisms underlying the energetic homeostasis paved the way to more effective therapeutic hypotheses as compared to traditional treatments. Since obesity is a complex issue, it requires a multidisciplinary approach which is difficult to implement. However, new drugs appear promising. Currently, therapeutic success is discrete in the short term, but unsatisfying in the long term due to the high probability of body weight gain...
May 2024: Giornale Italiano di Cardiologia
#4
Noemi Valenti, Antonio Di Monaco, Imma Romanazzi, Nicola Vitulano, Federica Troisi, Federico Quadrini, Massimo Grimaldi
BACKGROUND: There are some functional bradyarrhythmias that are caused by a dysregulation of the autonomic nervous system, for which a therapeutic strategy of cardioneuroablation (CNA) is conceivable. CASE SUMMARY: In this study, we report the case of a 19-year-old woman with a non-congenital third-degree atrioventricular block (AVB), symptomatic for lipothymia and dyspnea caused by mild exertion. She had a structurally normal heart and no other comorbidities. The atropine test and the exercise stress test documented a sinus tachycardia at 190 bpm with a 2:1 AVB, a narrow QRS, and an atrioventricular conduction of 1:1 until reaching a sinus rhythm rate of 90 bpm...
2024: Frontiers in Cardiovascular Medicine
#5
JOURNAL ARTICLE
Raphaël Amar, Marjorie Salga, Mickaël Tordjman, Nadia Venturelli, Lionelle Nkam, Madalina Jacota, Lamiae Grimaldi-Bensouda, Fabien Cale, Robert-Yves Carlier
PURPOSE: Neurogenic heterotopic ossification (NHO) of the hip is a frequent complication of spinal cord injuries, often requiring surgical management. Pre-surgical imaging assessment is essential, usually with computed tomography (CT)-scan. We aimed to compare magnetic resonance imaging (MRI) and CT for pre-surgical imaging assessment of the NHO, particularly for their relationships with vessels and nerves. METHOD: This prospective study included consecutive patients who underwent surgery for NHO from July 2019 to April 2022...
April 10, 2024: European Journal of Radiology
#6
REVIEW
Iris Parrini, Fabiana Lucà, Carmelo Massimiliano Rao, Stefano Cacciatore, Carmine Riccio, Massimo Grimaldi, Michele Massimo Gulizia, Fabrizio Oliva, Felicita Andreotti
Beta blockers (BBs) play a crucial role in enhancing the quality of life and extending the survival of patients with heart failure and reduced ejection fraction (HFrEF). Initiating the therapy at low doses and gradually titrating the dose upwards is recommended to ensure therapeutic efficacy while mitigating potential adverse effects. Vigilant monitoring for signs of drug intolerance is necessary, with dose adjustments as required. The management of older HF patients requires a case-centered approach, taking into account individual comorbidities, functional status, and frailty...
April 5, 2024: Journal of Clinical Medicine
#7
JOURNAL ARTICLE
Mirco Pozzi, Pietro Susini, Davide di Seclì, Michela Schettino, Luca Grimaldi, Roberto Cuomo, Carlos Weck Roxo
Introduction: Augmentation rhinoplasty traditionally represents a serious challenge for plastic surgeons. The association with centrofacial lipofilling is a great approach to achieve harmonious, aesthetic results. The aim of this article is to describe our personal association between Augmentation Rhinoplasty and Centrofacial Lipofilling (ARCL) in non-Caucasian patients. Materials and Methods: In this study, we retrospectively reviewed patients treated with ARCL at our institution between January 2019 and December 2023...
March 28, 2024: Journal of Clinical Medicine
#8
JOURNAL ARTICLE
Riccardo Levi, Maximiliano Mollura, Giovanni Savini, Federico Garoli, Massimiliano Battaglia, Angela Ammirabile, Luca A Cappellini, Simona Superbi, Marco Grimaldi, Riccardo Barbieri, Letterio S Politi
Radiomics features (RFs) studies have showed limitations in the reproducibility of RFs in different acquisition settings. To date, reproducibility studies using CT images mainly rely on phantoms, due to the harness of patient exposure to X-rays. The provided CadAIver dataset has the aims of evaluating how CT scanner parameters effect radiomics features on cadaveric donor. The dataset comprises 112 unique CT acquisitions of a cadaveric truck acquired on 3 different CT scanners varying KV, mA, field-of-view, and reconstruction kernel settings...
April 11, 2024: Scientific Data
#9
REVIEW
Alison Grimaldi, Rebecca Mellor, Anthony Nasser, Bill Vicenzino, David J Hunter
Tendinopathy describes persistent tendon pain and loss of function related to mechanical loading. Two common hip tendinopathies seen in practice are gluteal tendinopathy and proximal hamstring tendinopathy. Both conditions can be frustrating for patients and clinicians due to the delay in diagnosis, significant disability caused and lack of response to common treatments. Tendinopathy is a clinical diagnosis and can most often be made using findings from the patient interview and pain provocation tests, without the need for imaging...
2024: Rheumatology Advances in Practice
#10
RANDOMIZED CONTROLLED TRIAL
Wassilios G Meissner, Philippe Remy, Caroline Giordana, David Maltête, Pascal Derkinderen, Jean-Luc Houéto, Mathieu Anheim, Isabelle Benatru, Thomas Boraud, Christine Brefel-Courbon, Nicolas Carrière, Hélène Catala, Olivier Colin, Jean-Christophe Corvol, Philippe Damier, Estelle Dellapina, David Devos, Sophie Drapier, Margherita Fabbri, Vanessa Ferrier, Alexandra Foubert-Samier, Solène Frismand-Kryloff, Aurore Georget, Christine Germain, Stéphane Grimaldi, Clémence Hardy, Lucie Hopes, Pierre Krystkowiak, Brice Laurens, Romain Lefaucheur, Louise-Laure Mariani, Ana Marques, Claire Marse, Fabienne Ory-Magne, Vincent Rigalleau, Hayet Salhi, Amandine Saubion, Simon R W Stott, Claire Thalamas, Claire Thiriez, Mélissa Tir, Richard K Wyse, Antoine Benard, Olivier Rascol
BACKGROUND: Lixisenatide, a glucagon-like peptide-1 receptor agonist used for the treatment of diabetes, has shown neuroprotective properties in a mouse model of Parkinson's disease. METHODS: In this phase 2, double-blind, randomized, placebo-controlled trial, we assessed the effect of lixisenatide on the progression of motor disability in persons with Parkinson's disease. Participants in whom Parkinson's disease was diagnosed less than 3 years earlier, who were receiving a stable dose of medications to treat symptoms, and who did not have motor complications were randomly assigned in a 1:1 ratio to daily subcutaneous lixisenatide or placebo for 12 months, followed by a 2-month washout period...
April 4, 2024: New England Journal of Medicine
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REVIEW
Fabiana Lucà, Fabrizio Oliva, Maurizio Giuseppe Abrignani, Stefania Angela Di Fusco, Mauro Gori, Simona Giubilato, Roberto Ceravolo, Pier Luigi Temporelli, Stefano Cornara, Carmelo Massimiliano Rao, Giorgio Caretta, Andrea Pozzi, Giulio Binaghi, Alessandro Maloberti, Concetta Di Nora, Irene Di Matteo, Anna Pilleri, Sandro Gelsomino, Carmine Riccio, Massimo Grimaldi, Furio Colivicchi, Michele Massimo Gulizia
Heart failure with preserved ejection fraction (HFpEF) is characterized by a notable heterogeneity in both phenotypic and pathophysiological features, with a growing incidence due to the increase in median age and comorbidities such as obesity, arterial hypertension, and cardiometabolic disease. In recent decades, the development of new pharmacological and non-pharmacological options has significantly impacted outcomes, improving clinical status and reducing mortality. Moreover, a more personalized and accurate therapeutic management has been demonstrated to enhance the quality of life, diminish hospitalizations, and improve overall survival...
February 28, 2024: Journal of Clinical Medicine
#12
JOURNAL ARTICLE
Tarek Sharshar, Lamiae Grimaldi-Bensouda, Shidasp Siami, Alain Cariou, Abdel Ben Salah, Pierre Kalfon, Romain Sonneville, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Bruno Megarbane, Stephane Gaudry, Haikel Oueslati, Segolene Robin-Lagandre, Carole Schwebel, Aurelien Mazeraud, Djillali Annane, Lionelle Nkam, Diane Friedman
PURPOSE: Critical illness is associated with long-term increased mortality and impaired quality of life (QoL). We assessed whether multidisciplinary consultations would improve outcome at 12 months (M12) after intensive care unit (ICU) discharge. METHODS: We performed an open, multicenter, parallel-group, randomized clinical trial. Eligible are patients discharged alive from ICU in 11 French hospitals between 2012 and 2018. The intervention group had a multidisciplinary face-to-face consultation involving an intensivist, a psychologist, and a social worker at ICU discharge and then at M3 and M6 (optional)...
April 8, 2024: Intensive Care Medicine
#13
EDITORIAL
Federica Perelli, Chiara Grimaldi, Massimo Candiani, Lorenzo Masieri, Alberto Mantovani
No abstract text is available yet for this article.
2024: Frontiers in Surgery
#14
Tatiana Horowitz, Eric Guedj, Alexandre Eusebio, Frédérique Fluchère, Jean-Philippe Azulay, Emilien Delmont, Stephan Grimaldi
BACKGROUND: Phenotypes of CANVAS are increasingly diversified, including bradykinesia and dysautonomia, so that its primary differential diagnoses are multiple system atrophy-cerebellar type (MSA-c), and spinocerebellar ataxia type 3 (SCA3). This case series aims to highlight key molecular imaging findings in CANVAS. CASES: We report a case series of six patients with CANVAS who underwent nuclear medicine examinations in our center and 13 patients from the literature...
April 4, 2024: Movement Disorders Clinical Practice
#15
JOURNAL ARTICLE
L Thomas, D Şahin, A S Adam, C M Grimaldi, N M Ryan, S L Duffy, J N Underwood, W J Kennington, J P Gilmour
Climate change is restructuring natural ecosystems. The direct impacts of these events on biodiversity and community structure are widely documented, but the impacts on the genetic variation of populations remains largely unknown. We monitored populations of Acropora coral on a remote coral reef system in northwest Australia for two decades and through multiple cycles of impact and recovery. We combined these demographic data with a temporal genetic dataset of a common broadcast spawning corymbose Acropora to explore the spatial and temporal patterns of connectivity underlying recovery...
April 4, 2024: Communications Biology
#16
JOURNAL ARTICLE
Elena De Cristofaro, Pierre Lafeuille, Jérôme Rivory, Jean Grimaldi, Louis Jean Masgnaux, Alexandru Lupu, Mathieu Pioche
No abstract text is available yet for this article.
December 2024: Endoscopy
#17
JOURNAL ARTICLE
F Pizza, P Maida, C Bertoglio, A Antinori, F M Mongardini, L Cerbara, I Sordelli, B D Alampi, G Marte, L Morini, S Grimaldi, S Gili, L Docimo, C Gambardella
BACKGROUND: Surgical management of large ventral hernias (VH) has remained a challenge. Various techniques like anterior component separation and posterior component separation (PCS) with transversus abdominis release (TAR) have been employed. Despite the initial success, the long-term efficacy of TAR is not yet comprehensively studied. Authors aimed to investigate the early-, medium-, and long-term outcomes and health-related quality of life (QoL) in patients treated with PCS and TAR...
April 3, 2024: Hernia: the Journal of Hernias and Abdominal Wall Surgery
#18
JOURNAL ARTICLE
Gaia Grimaldi, Masood R Khan, Antonio Leo, Mario Scuderi, Francesco Rizzo, Andrea Augieri, Giuseppe Celentano, Armando Galluzzi, Michela Iebole, Massimiliano Polichetti, Angela Nigro, Valeria Braccini
Discovery of iron-based superconductors paved the way to a competitor of high-temperature superconductors, easier to produce, better performing in high fields, and promising to be less expensive. Critical parameters are investigated by resistivity measurements as a function of temperature, field, and angle R ( T,H,θ ). This work presents a deep analysis of H - θ phase diagram of PLD-processed Fe(Se,Te) superconducting films, thus revealing material and pinning anisotropy at once. By selecting different thresholds along the R ( T,H,θ ) curves, all possible regimes emerge...
April 19, 2024: IScience
#19
JOURNAL ARTICLE
Brunella Perfetto, Giovanna Paduano, Elena Grimaldi, Vincenza Sansone, Giovanna Donnarumma, Gabriella Di Giuseppe
BACKGROUND: Despite the efforts of the World Health Organization, some childhood viral diseases, for which there is already an effective vaccine, have not yet been eradicated. Among these, we find varicella, mumps, measles, and rubella, which although in most cases have a benign course, can in some cases be responsible for infectious outbreaks, especially in nosocomial settings. The aim of this study was to verify the immunological situation of a cohort of trainee obstetricians in Campania regarding varicella, mumps, measles, and rubella to be used as an example for the evaluation of possible preventive strategies to avoid infectious outbreaks...
March 20, 2024: Vaccines
#20
REVIEW
Angelo Onorato, Eugenia Guida, Ambra Colopi, Susanna Dolci, Paola Grimaldi
Germ cell tumors (GCTs) are relatively rare tumors. However, they are the most diagnosed malignancies occurring in the testis among men aged between 15 and 40 years. Despite high aneuploidy and a paucity of somatic mutations, several genomic and transcriptomic assays have identified a few significantly mutated somatic genes, primarily KIT and K-RAS. The receptor Tyrosine Kinase (RTK) pathway and the downstream related Mitogen-Activated Protein Kinase (MAPK) cascades are crucial signal transduction pathways that preside over various cellular processes, including proliferation, differentiation, apoptosis, and responses to stressors...
February 29, 2024: Life
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