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https://www.readbyqxmd.com/read/28813709/natural-history-of-localized-and-locally-advanced-lung-atypical-carcinoid-after-complete-resection-a-joined-french-italian-multicentric-retrospective-study
#1
Francesca Marciello, Olaf Mercier, Piero Ferolla, Jean-Yves Scoazec, Pier Luigi Filosso, Alain Chapelier, Gianluca Guggino, Roberto Monaco, Franco Grimaldi, Stefano Pizzolitto, Joël Guygay, Bertrand Richard de Latour, Dario Giuffrida, Elisabeth Longchampt, Vincent Thomas de Montpreville, Élie Fadel, Annamaria Colao, David Planchard, Mauro Papotti, Antongiulio Faggiano, Eric Baudin
No abstract text is available yet for this article.
August 17, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28808927/lymphopaenia-in-cardiac-arrest-patients
#2
Paola Villois, David Grimaldi, Savino Spadaro, Claudia Righy Shinotsuka, Vito Fontana, Sabino Scolletta, Federico Franchi, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
BACKGROUND: A decrease in circulating lymphocytes has been described as a marker of poor prognosis after septic shock; however, scarce data are available after cardiac arrest (CA). The aim of this study was to evaluate the impact of lymphopaenia after successful cardiopulmonary resuscitation. METHODS: This is a retrospective analysis of an institutional database including all adult CA patients admitted to the intensive care unit (ICU) between January 2007 and December 2014 who survived for at least 24 h...
August 14, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28783029/revised-classification-of-the-subfamily-leishmaniinae-trypanosomatidae
#3
Alexei Y Kostygov, Vyacheslav Yurchenko
In the present study, we critically revised the recently proposed classification of the subfamily Leishmaniinae Maslov et Lukeš in Jirků et al., 2012. Agreeing with erection of the genus Zelonia Shaw, Camargo et Teixeira in Espinosa et al., 2017 and the subgenus Mundinia Shaw, Camargo et Teixeira in Espinosa et al., 2017 within the genus Leishmania Ross, 1908, we argue that other changes are not well justified. We propose to: (i) raise Paraleishmania Cupolillo, Medina-Acosta, Noyes, Momen et Grimaldi, 2000 to generic rank; (ii) create a new genus Borovskyia gen...
July 10, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28765094/non-coding-rnas-as-a-new-dawn-in-tumor-diagnosis
#4
REVIEW
Anna Grimaldi, Mayra Rachele Zarone, Carlo Irace, Silvia Zappavigna, Angela Lombardi, Hiromichi Kawasaki, Michele Caraglia, Gabriella Misso
The current knowledge about non-coding RNAs (ncRNAs) as important regulators of gene expression in both physiological and pathological conditions, has been the main engine for the design of innovative platforms to finalize the pharmacological application of ncRNAs as either therapeutic tools or as molecular biomarkers in cancer. Biochemical alterations of cancer cells are, in fact, largely supported by ncRNA disregulation in the tumor site, which, in turn, reflects the cancer-associated specific modification of circulating ncRNA expression pattern...
July 29, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28761789/an-exceptionally-preserved-110-million-years-old-praying-mantis-provides-new-insights-into-the-predatory-behaviour-of-early-mantodeans
#5
Marie K Hörnig, Joachim T Haug, Carolin Haug
Mantodeans or praying mantises are flying insects and well known for their raptorial behaviour, mainly performed by their first pair of thoracic appendages. We describe here a new, exceptionally preserved specimen of the early mantodean Santanmantis axelrodi Grimaldi, 2003 from the famous 110 million years old Crato Formation, Brazil. The incomplete specimen preserves important morphological details, which were not known in this specific form before for this species or any other representative of Mantodea. Unlike in modern representatives or other fossil forms of Mantodea not only the first pair of thoracic appendages shows adaptations for predation...
2017: PeerJ
https://www.readbyqxmd.com/read/28761747/eribulin-for-metastatic-breast-cancer-mbc-treatment-a-retrospective-multicenter-study-based-in-campania-south-italy-eri-001-trial
#6
Michele Orditura, Adriano Gravina, Ferdinando Riccardi, Anna Diana, Carmela Mocerino, Luigi Leopaldi, Alessio Fabozzi, Guido Giordano, Raffaele Nettuno, Pasquale Incoronato, Maria Luisa Barzelloni, Roberta Caputo, Agata Pisano, Giuseppe Grimaldi, Geppino Genua, Vincenzo Montesarchio, Enrico Barbato, Giovanni Iodice, Eva Lieto, Eugenio Procaccini, Roberto Mabilia, Antonio Febbraro, Michelino De Laurentiis, Fortunato Ciardiello
BACKGROUND: On the basis of the results of two pivotal phase III clinical trials, eribulin mesylate is currently approved in EU for the treatment of advanced breast cancer (aBC) in patients who have previously received an anthracycline and a taxane in either the adjuvant or the metastatic setting, and at least one chemotherapeutic regimen for metastatic disease. METHODS: In our study, we investigated the efficacy and tolerability of eribulin as second or further line chemotherapy in 137 women affected by aBC...
2017: ESMO Open
https://www.readbyqxmd.com/read/28749789/surgical-approach-to-piles-at-risk-of-severe-postoperative-pain-tricks-and-tips
#7
Domenico Tuscano, Linda D'Amore, Fabio Gaj, Paolo Bruzzone, Elena Annesi, Daniele Ceccarelli, Paolox Paolo Negro, Maria Romana Grimaldi, Francesco Gossetti
AIM: Aim of the present study is to propose a clinic-therapeutic course for the treatment of hemorrhoidal disease able to combine radical anatomic surgery with a painless postoperative path. MATERIAL OF STUDY: The present study is based on the evaluation of 20 selected patients who underwent radical hemorrhoidectomy for very high grade hemorrhoidal disease. The clinical course was characterized by careful bowel cleansing, hemorrhoidectomy according to Milligan-Morgan using LigaSure, intraoperative perianal infiltration of Ropivacaine and postoperative use of analgesic drugs...
July 24, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28748806/clinical-trial-research-in-focus-rethinking-trials-in-sepsis
#8
David Grimaldi, Jean-Louis Vincent
No abstract text is available yet for this article.
August 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28726542/generation-and-functional-characterization-of-anti-human-and-anti-mouse-il-36r-antagonist-monoclonal-antibodies
#9
Rajkumar Ganesan, Ernest L Raymond, Detlev Mennerich, Joseph R Woska, Gary Caviness, Christine Grimaldi, Jennifer Ahlberg, Rocio Perez, Simon Roberts, Danlin Yang, Kavita Jerath, Kristopher Truncali, Lee Frego, Eliud Sepulveda, Priyanka Gupta, Su-Ellen Brown, Michael D Howell, Keith A Canada, Rachel Kroe-Barrett, Jay S Fine, Sanjaya Singh, M Lamine Mbow
Deficiency of interleukin (IL)-36 receptor antagonist (DITRA) syndrome is a rare autosomal recessive disease caused by mutations in IL36RN. IL-36R is a cell surface receptor and a member of the IL1R family that is involved in inflammatory responses triggered in skin and other epithelial tissues. Accumulating evidence suggests that IL-36R signaling may play a role in the pathogenesis of psoriasis. Therapeutic intervention of IL-36R signaling offers an innovative treatment paradigm for targeting epithelial cell-mediated inflammatory diseases such as the life-threatening psoriasis variant called generalized pustular psoriasis (GPP)...
July 20, 2017: MAbs
https://www.readbyqxmd.com/read/28720955/crystallinity-properties-and-crystallization-behavior-of-chocolate-fat-blends
#10
Thais Lomonaco Teodoro da Silva, Renato Grimaldi, Guilherme Andrade Calligaris, Lisandro Pavie Cardoso, Lireny Aparecida Guaraldo Gonçalves
Cocoa butter (CB) provides unique crystallization characteristics to chocolates and confectionary products; hence, it is an important value-add product. However, other alternative fats that minimally affect the crystallization behaviour of chocolates and confectionary products are now being increasingly used. This study analyzed the crystallization behaviour of CB, cocoa butter substitutes (CBSs), and their blends. Blends were prepared using CBS concentrations: 5, 10, 15, 20 and 37.5%. CB, CBS, and their blends were evaluated by following analysis: solid fat content, isothermal analysis, polarized light microscopic, thermal behaviour, X-ray diffraction and consistency...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28717668/different-renal-phenotypes-in-related-adult-males-with-fabry-disease-with-the-same-classic-genotype
#11
Renzo Mignani, Mariarita Moschella, Giovanna Cenacchi, Ilaria Donati, Marta Flachi, Daniela Grimaldi, Davide Cerretani, Paola De Giovanni, Marcello Montevecchi, Angelo Rigotti, Alessandro Ravasio
BACKGROUND: Fabry disease related patients with classical mutation usually exhibit similar severe phenotype especially concerning renal manifestation. METHODS: A dry blood spot screening (DBS) and the DNA analysis has been performed in a 48-year-old man (Patient 1) because of paresthesia. RESULTS: The DBS revealed absent leukocyte α-Gal A enzyme activity while DNA analysis identified the I354K mutation. Serum creatinine and e-GFR were in normal range and also albuminuria and proteinuria were absent...
July 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28715581/incidence-and-factors-influencing-retinal-displacement-in-eyes-treated-for-rhegmatogenous-retinal-detachment-with-vitrectomy-and-gas-or-silicone-oil
#12
MULTICENTER STUDY
Roberto dell'Omo, Andrea Scupola, Davide Viggiano, Maria Grazia Sammarco, Serena De Turris, Mario R Romano, Gabriela Grimaldi, Ermanno dell'Omo, Ciro Costagliola
Purpose: The purpose of this study was to study the incidence and factors influencing retinal displacement in eyes treated for rhegmatogenous retinal detachment (RRD) with pars plana vitrectomy (PPV) and gas or silicone oil. Methods: This was a prospective observational case series. One hundred twenty-five eyes with macula-off RRD from 125 patients underwent 25-gauge PPV at two vitreoretinal institutional practices. Eyes without proliferative vitreoretinopathy (PVR) or PVR grade A were tamponated with sulfur hexafluoride (SF6) gas, whereas eyes with PVR grade B received 1000 centistokes silicone oil (SO)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28712267/use-of-topical-ephedrine-and-naphazoline-in-the-treatment-of-a-keratoacanthoma-two-case-reports
#13
Maria C Fortuna, Miriam Grimaldi, Valentina Garelli, Giulia Pranteda, Guglielmo Pranteda, Donato DI Nunno, Marta Carlesimo, Alfredo Rossi
No abstract text is available yet for this article.
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28704129/electromagnetic-information-transfer-through-aqueous-system
#14
Alberto Foletti, Mario Ledda, Maria Grazia Lolli, Settimio Grimaldi, Antonella Lisi
Several beneficial effects of the electromagnetic information transfer through aqueous system (EMITTAS) procedure have previously been reported in vitro. The clinical potential of this procedure has also started to be evaluated. Information flow in biological systems can be investigated through chemical and molecular approaches or by a biophysical approach focused on endogenous electrodynamic activities. Electromagnetic signals are endogenously generated at different levels of the biological organization and, likely, play an active role in synchronizing internal cell function or local/systemic adaptive response...
July 13, 2017: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/28703103/shining-light-in-a-dark-landscape-mri-evaluation-of-unusual-localization-of-endometriosis
#15
Benedetta Gui, Anna Lia Valentini, Valeria Ninivaggi, Maura Miccò, Viola Zecchi, Pier Paolo Grimaldi, Francesco Cambi, Maurizio Guido, Lorenzo Bonomo
Endometriosis is a disease distinguished by the presence of endometrial tissue outside the uterine cavity with intralesional recurrent bleeding and resulting fibrosis. The most common locations for endometriosis are the ovaries, pelvic peritoneum, uterosacral ligaments, and torus uterinus. Typical symptoms are secondary dysmenorrhea and cyclic or chronic pelvic pain. Unusual sites of endometriosis may be associated with specific symptoms depending on the localization. Atypical pelvic endometriosis localizations can occur in the cervix, vagina, round ligaments, ureter, and nerves...
July 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28700357/are-three-weeks-hypofractionated-radiation-therapy-hfrt-comparable-to-six-weeks-for-newly-diagnosed-glioblastoma-patients-results-of-a-phase-ii-study
#16
Pierina Navarria, Federico Pessina, Stefano Tomatis, Riccardo Soffietti, Marco Grimaldi, Egesta Lopci, Arturo Chiti, Antonella Leonetti, Alessandra Casarotti, Marco Rossi, Luca Cozzi, Anna Maria Ascolese, Matteo Simonelli, Simona Marcheselli, Armando Santoro, Elena Clerici, Lorenzo Bello, Marta Scorsetti
BACKGROUND: The current standard of care for newly diagnosed glioblastoma (GBM) is surgical resection, followed by radiation therapy (RT) with concurrent and adjuvant temozolomide chemotherapy (TMZ-CHT).. The patients outcome is still poor. In this study we evaluated hypofractionated radiation therapy (HFRT), instead of standard fractionated radiation therapy, with concomitant and adjuvant TMZ chemotherapy, in terms of safety and effectiveness. METHODS: Patients with newly diagnosed GBM, Karnofsky performance scale (KPS) ≥70, and tumor up to 10 cm underwent maximal feasible surgical resection were treated...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28699929/arcuate-nerve-fiber-layer-changes-after-internal-limiting-membrane-peeling-in-idiopathic-epiretinal-membrane
#17
Andrea Scupola, Gabriela Grimaldi, Edoardo Abed, Maria G Sammarco, Andrea Giudiceandrea, Andrea Greco, Paola Sasso, Maria A Blasi
PURPOSE: To analyze the relationship between swelling of the arcuate nerve fiber layer (SANFL) and long-term decrease of retinal nerve fiber layer thickness after internal limiting membrane peeling for idiopathic epiretinal membrane, and to investigate if SANFL is related to a mechanical surgical damage. METHODS: Prospective, interventional consecutive case series of 46 eyes that underwent combined epiretinal membrane/internal limiting membrane peeling for idiopathic epiretinal membrane...
July 7, 2017: Retina
https://www.readbyqxmd.com/read/28694149/host-regulation-by-the-ectophagous-parasitoid-wasp-bracon-nigricans
#18
Andrea Becchimanzi, Maddalena Avolio, Ilaria Di Lelio, Adriana Marinelli, Paola Varricchio, Annalisa Grimaldi, Magda de Eguileor, Francesco Pennacchio, Silvia Caccia
The host regulation process has been widely investigated in endophagous parasitoid wasps, which in most cases finely interact with living hosts (i.e. koinobiont parasitoids). In contrast, only very limited information is available for ectophagous parasitoids that permanently paralyze and rapidly suppress their victims (i.e. idiobiont parasitoids). Here we try to fill this research gap by investigating the host regulation by Bracon nigricans, an ectophagous idiobiont wasp species. Parasitism, mainly by venom action, is able to redirect host metabolism in order to enhance its nutritional suitability for the developing parasitoid larvae and to provide the required metabolic support to host tissues...
July 8, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28681474/probing-the-menasemiquinone-binding-mode-to-nitrate-reductase-a-by-selective-2h-15n-labelling-hyscore-spectroscopy-and-dft-modeling
#19
Maryam Seif Eddine, Frédéric Biaso, Rodrigo Arias-Cartin, Eric Pilet, Julia Rendon, Sevdalina Lyubenova, Farida Seduk, Bruno Guigliarelli, Axel Magalon, Stephane Grimaldi
In vivo specific isotope labelling at the residue or substituent level is used to probe menasemiquinone (MSK) binding to the quinol oxidation site of respiratory nitrate reductase A (NarGHI) from E. coli. 15N selective labelling of His15Nδ or Lys15Nξ in combination with Hyperfine sublevel correlation, (HYSCORE) spectroscopy unambiguously identified His15N as direct hydrogen bond donor to the radical. In contrast, an essentially anisotropic coupling to Lys15Nξ consistent with a through space magnetic interaction was resolved...
July 5, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28675778/hip-abductor-muscle-activity-during-walking-in-individuals-with-gluteal-tendinopathy
#20
Kim Allison, Sauro E Salomoni, Kim L Bennell, Tim V Wrigley, Francois Hug, Bill Vicenzino, Alison Grimaldi, Paul W Hodges
The external hip adduction moment during walking is greater in individuals with gluteal tendinopathy (GT) than pain-free controls. Although this likely represents a greater demand on the hip abductor muscles implicated in GT, no study has investigated activation of these muscles in GT. For this purpose, fine wire electrodes were inserted into the segments of the gluteus minimus and medius muscles, and surface electrodes placed on the tensor fascia lata, upper gluteus maximus and vastus lateralis muscles of thirteen individuals with, and thirteen without, GT...
July 4, 2017: Scandinavian Journal of Medicine & Science in Sports
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