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https://www.readbyqxmd.com/read/28916936/does-diabetes-mellitus-comorbidity-affect-in-hospital-mortality-and-length-of-stay-analysis-of-administrative-data-in-an-italian-academic-hospital
#1
Francesca Valent, Laura Tonutti, Franco Grimaldi
AIMS: Hospitalized patients with comorbid diabetes mellitus may have worse outcomes than the others. We conducted a study to assess whether comorbid diabetes affects in-hospital mortality and length of stay. METHODS: For this population-based study, we analyzed the administrative databases of the Regional Health Information System of the Region Friuli Venezia Giulia, where the Hospital of Udine is located. Hospital discharge data were linked at the individual patient level with the regional Diabetes Mellitus Registry to identify diabetic patients...
September 15, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28911206/identification-of-the-molecular-dysfunction-caused-by-glutamate-dehydrogenase-s445l-mutation-responsible-for-hyperinsulinism-hyperammonemia
#2
Mariagrazia Grimaldi, Melis Karaca, Livia Latini, Estelle Brioudes, Thomas Schalch, Pierre Maechler
Congenital hyperinsulinism/hyperammonemia (HI/HA) syndrome gives rise to unregulated protein-induced insulin secretion from pancreatic beta-cells, fasting hypoglycemia and elevated plasma ammonia levels. Mutations associated with HI/HA were identified in the Glud1 gene, encoding for glutamate dehydrogenase (GDH). We aimed at identifying the molecular causes of dysregulation in insulin secretion and ammonia production conferred by the most frequent HI/HA mutation Ser445Leu. Following transduction with adenoviruses carrying the human GDH-wild type or GDH-S445L-mutant gene, immunoblotting showed efficient expression of the transgenes in all the investigated cell types...
September 15, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28901713/neural-correlates-of-interoception-effects-of-interoceptive-focus-and-relationship-to-dimensional-measures-of-body-awareness
#3
Emily R Stern, Stephanie J Grimaldi, Alexandra Muratore, James Murrough, Evan Leibu, Lazar Fleysher, Wayne K Goodman, Katherine E Burdick
Interoception has been defined as the sensing of the physiological condition of the body, with interoceptive sensibility (IS) characterizing an individual's self-reported awareness of internal sensation. IS is a multidimensional construct including not only the tendency to be aware of sensation but also how sensations are interpreted, regulated, and used to inform behavior, with different dimensions relating to different aspects of health and disease. Here we investigated neural mechanisms of interoception when healthy individuals attended to their heartbeat and skin temperature, and examined the relationship between neural activity during interoception and individual differences in self-reported IS using the Multidimensional Scale of Interoceptive Awareness (MAIA)...
September 12, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28882368/the-epigenetic-promise-to-improve-prognosis-of-heart-failure-and-heart-transplantation
#4
REVIEW
Chiara Sabia, Antonietta Picascia, Vincenzo Grimaldi, Cristiano Amarelli, Ciro Maiello, Claudio Napoli
Heart transplantation is still the only possible life-saving treatment for end-stage heart failure, the critical epilogue of several cardiac diseases. Epigenetic mechanisms are being intensively investigated because they could contribute to establishing innovative diagnostic and predictive biomarkers, as well as ground-breaking therapies both for heart failure and heart transplantation rejection. DNA methylation and histone modifications can modulate the innate and adaptive immune response by acting on the expression of immune-related genes that, in turn, are crucial determinants of transplantation outcome...
August 15, 2017: Transplantation Reviews
https://www.readbyqxmd.com/read/28868980/nanoparticle-based-strategies-for-cancer-immunotherapy-and-immunodiagnostics
#5
Anna Maria Grimaldi, Mariarosaria Incoronato, Marco Salvatore, Andrea Soricelli
Although recent successes in clinical trials are strengthening research focused on cancer immunology, the poor immunogenicity and off-target side effects of immunotherapeutics remain major challenges in translating these promising approaches to clinically feasible therapies in the treatment of a large range of tumors. Nanotechnology offers target-based approaches, which have shown significant improvements in the rapidly advancing field of cancer immunotherapy. Here, we first discuss the chemical and physical features of nanoparticulate systems that can be tuned to address the anticancer immune response, and then review recent, key examples of the exploited strategies, ranging from nanovaccines to NPs revising the tumor immunosuppressive microenvironment, up to immunotherapeutic multimodal NPs...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28868030/association-of-posterior-reversible-encephalopathy-syndrome-and-transient-apical-ballooning-syndrome-takotsubo-first-case-report-of-a-man-and-review-of-the-literature
#6
Stephan Grimaldi, Emilie Doche, Caroline Rey, Nadia Laksiri, Salah Boussen, Jacques Quilici, Emmanuelle Robinet, Fabien Devemy, Jean Pelletier
INTRODUCTION: An association of posterior reversible encephalopathy syndrome (PRES) and takotsubo is rare. We present the first case of a male patient. CASE REPORT: A 69-year-old man presented to the hospital in a persistent comatose state following a generalized tonic-clonic seizure with high blood pressure. The electrocardiogram revealed transient left bundle branch block. Troponin and BNP were elevated. Cardiac ultrasound showed large apical akinesia with altered left ventricular ejection fraction, and the left ventriculogram showed characteristic regional wall motion abnormalities involving the mid and apical segments...
May 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28864818/the-italian-pharmacovigilance-program-an-observational-study-of-adverse-effects-of-natalizumab-in-multiple-sclerosis-therapy
#7
Sabrina Giacoppo, Maria Ruscica, Luigi Maria Grimaldi, Placido Bramanti, Emanuela Mazzon
BACKGROUND This study shows the results of a regional pharmacovigilance program on Natalizumab therapy in relapsing-remitting multiple sclerosis (RR-MS) patients after 3 years of experience. MATERIAL AND METHODS The primary objectives of this study were to estimate the incidence of expected and unexpected adverse effects correlated to Natalizumab therapy in a cohort of 88 RR-MS patients from Sicily, Italy, and to investigate the procedures adopted by the physicians to minimize the risk of developing severe adverse reactions correlated to Natalizumab therapy...
September 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28859628/assessment-of-thoracic-ultrasound-in-complementary-diagnosis-and-in-follow-up-of-community-acquired-pneumonia-cap
#8
Maria D'Amato, Gaetano Rea, Vincenzo Carnevale, Maria Arcangela Grimaldi, Anna Rita Saponara, Eric Rosenthal, Michele Maria Maggi, Lucia Dimitri, Marco Sperandeo
BACKGROUND: Chest X-ray (CXR) is the primary diagnostic tool for community-acquired pneumonia (CAP). Some authors recently proposed that thoracic ultrasound (TUS) could valuably flank or even reliably substitute CXR in the diagnosis and follow-up of CAP. We investigated the clinical utility of TUS in a large sample of patients with CAP, to challenge the hypothesis that it may be a substitute for CXR. METHODS: Out of 645 consecutive patients with a CXR-confirmed CAP diagnosed in the emergency room of our hospital over a three-years period, 510 were subsequently admitted to our department of Internal Medicine...
August 31, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28859243/ultrafast-charge-transfer-and-upconversion-in-zn-%C3%AE-tetraaminophthalocyanine-functionalized-pbs-nanostructures-probed-by-transient-absorption-spectroscopy
#9
Jannika Lauth, Gianluca Grimaldi, Sachin Kinge, Arjan J Houtepen, Laurens D A Siebbeles, Marcus Scheele
We functionalize PbS nanocrystals with the organic semiconductor Zn β-tetraaminophthalocyanine to design a nanostructured solid-state material with frequent organic-inorganic interfaces. By transient absorption and fluorescence spectroscopy, we investigate the optoelectronic response of this hybrid material under near-infrared excitation to find efficient charge transfer from the nanocrystals to the molecules. We demonstrate that the material undergoes cooperative sensitization of two nanocrystals followed by photon upconversion and singlet emission of the organic semiconductor...
August 31, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28846386/pressure-responsive-surfactant-free-co2-based-nanostructured-fluids
#10
Natascia Grimaldi, Paula Elena Rojas, Simon Stehle, Alba Cordoba, Ralf Schweins, Santi Sala, Stefan Luelsdorf, David Piña, Jaume Veciana, Jordi Faraudo, Alessandro Triolo, Andreas Siegfried Braeuer, Nora Ventosa
Microemulsions are extensively used in advanced material and chemical processing. However, considerable amounts of surfactant are needed for their formulation, which is a drawback due to both economic and ecological reasons. Here, we describe the nanostructuration of recently discovered surfactant-free, carbon dioxide (CO2)-based microemulsion-like systems in water/organic-solvent/CO2 pressurized ternary mixture. "Water-rich" nanodomains embedded into a "water-depleted" matrix have been observed and characterized by the combination of Raman spectroscopy, molecular dynamics simulations and small angle neutron scattering...
August 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28841540/laparoscopically-assisted-treatment-of-entero-atmospheric-fistula-following-abdominal-wall-repair-of-complex-incisional-hernia-case-report
#11
Francesca Ceci, Linda D'Amore, Maria Romana Grimaldi, Elena Annesi, Domenico Tuscano, Francesco Gossetti, Paolo Negro
INTRODUCTION: Entero-atmospheric fistula (EAF) is an uncommon complication. Its timing and surgical management could be extremely challenging because extensive adhesions may heavily affect the approach to the abdominal cavity. PRESENTATION OF CASE: We hereby report a case of EAF in a 70 year-old man. In order to control the fistula output and the surrounding tissue damage from enteric content, the patient was managed conservatively using different technical solutions...
August 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28832610/first-fossil-of-an-oestroid-fly-diptera-calyptratae-oestroidea-and-the-dating-of-oestroid-divergences
#12
Pierfilippo Cerretti, John O Stireman, Thomas Pape, James E O'Hara, Marco A T Marinho, Knut Rognes, David A Grimaldi
Calyptrate flies include about 22,000 extant species currently classified into Hippoboscoidea (tsetse, louse, and bat flies), the muscoid grade (house flies and relatives) and the Oestroidea (blow flies, bot flies, flesh flies, and relatives). Calyptrates are abundant in nearly all terrestrial ecosystems, often playing key roles as decomposers, parasites, parasitoids, vectors of pathogens, and pollinators. For oestroids, the most diverse group within calyptrates, definitive fossils have been lacking. The first unambiguous fossil of Oestroidea is described based on a specimen discovered in amber from the Dominican Republic...
2017: PloS One
https://www.readbyqxmd.com/read/28830159/tree-ansatz-percolation-of-hard-spheres
#13
Claudio Grimaldi
Suspensions of hard core spherical particles of diameter D with inter-core connectivity range δ can be described in terms of random geometric graphs, where nodes represent the sphere centers and edges are assigned to any two particles separated by a distance smaller than δ. By exploiting the property that closed loops of connected spheres become increasingly rare as the connectivity range diminishes, we study continuum percolation of hard spheres by treating the network of connected particles as having a tree-like structure for small δ/D...
August 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28827736/cellular-responses-induced-by-multi-walled-carbon-nanotubes-in-vivo-and-in-vitro-studies-on-the-medicinal-leech-macrophages
#14
Rossana Girardello, Nicolò Baranzini, Gianluca Tettamanti, Magda de Eguileor, Annalisa Grimaldi
The core characteristics of multi-wall carbon nanotubes (MWCNTs) are impressive and attractive for technology however, since their production and use is steadily increasing, their environmental dispersion could be potentially hazardous to animal and human health. For this reason, the identification of new methods and of reliable models to better understand MWCNT effects is essential. Here we propose the medicinal leech as an alternative model to assess the effects of MWCNTs on immune system. Our previous studies have already demonstrated that in vivo MWCNT treatment induces the activation of leech's macrophages...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28825713/spatially-and-time-resolved-magnetization-dynamics-driven-by-spin-orbit-torques
#15
Manuel Baumgartner, Kevin Garello, Johannes Mendil, Can Onur Avci, Eva Grimaldi, Christoph Murer, Junxiao Feng, Mihai Gabureac, Christian Stamm, Yves Acremann, Simone Finizio, Sebastian Wintz, Jörg Raabe, Pietro Gambardella
Current-induced spin-orbit torques are one of the most effective ways to manipulate the magnetization in spintronic devices, and hold promise for fast switching applications in non-volatile memory and logic units. Here, we report the direct observation of spin-orbit-torque-driven magnetization dynamics in Pt/Co/AlOx dots during current pulse injection. Time-resolved X-ray images with 25 nm spatial and 100 ps temporal resolution reveal that switching is achieved within the duration of a subnanosecond current pulse by the fast nucleation of an inverted domain at the edge of the dot and propagation of a tilted domain wall across the dot...
August 21, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28814137/pegylated-crosslinked-hyaluronic-acid-nanoparticles-designed-through-a-microfluidic-platform-for-nanomedicine
#16
Maria Russo, Anna Maria Grimaldi, Paolo Bevilacqua, Olimpia Tammaro, Paolo Antonio Netti, Enza Torino
AIM: A high versatile microfluidic platform is proposed to design, in a one-step strategy, PEGylated crosslinked hyaluronic acid nanoparticles (cHANPs) entrapping a magnetic resonance imaging contrast agent and a dye for multimodal imaging applications. MATERIALS & METHODS: Clinically relevant biomaterials were shaped in the form of spherical NPs through a microfluidic flow focusing approach. A comparison between post processing and simultaneous PEGylation is reported to evaluate the potentiality of the chemical decoration of the cHANPs in microfluidics...
August 17, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28813709/natural-history-of-localized-and-locally-advanced-lung-atypical-carcinoid-after-complete-resection-a-joined-french-italian-multicentric-retrospective-study
#17
Francesca Marciello, Olaf Mercier, Piero Ferolla, Jean-Yves Scoazec, Pier Luigi Filosso, Alain Chapelier, Gianluca Guggino, Roberto Monaco, Franco Grimaldi, Stefano Pizzolitto, Joël Guygay, Bertrand Richard de Latour, Dario Giuffrida, Elisabeth Longchampt, Vincent Thomas de Montpreville, Élie Fadel, Annamaria Colao, David Planchard, Mauro Papotti, Antongiulio Faggiano, Eric Baudin
No abstract text is available yet for this article.
August 17, 2017: Neuroendocrinology
https://www.readbyqxmd.com/read/28808927/lymphopaenia-in-cardiac-arrest-patients
#18
Paola Villois, David Grimaldi, Savino Spadaro, Claudia Righy Shinotsuka, Vito Fontana, Sabino Scolletta, Federico Franchi, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone
BACKGROUND: A decrease in circulating lymphocytes has been described as a marker of poor prognosis after septic shock; however, scarce data are available after cardiac arrest (CA). The aim of this study was to evaluate the impact of lymphopaenia after successful cardiopulmonary resuscitation. METHODS: This is a retrospective analysis of an institutional database including all adult CA patients admitted to the intensive care unit (ICU) between January 2007 and December 2014 who survived for at least 24 h...
August 14, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28783029/revised-classification-of-the-subfamily-leishmaniinae-trypanosomatidae
#19
Alexei Y Kostygov, Vyacheslav Yurchenko
In the present study, we critically revised the recently proposed classification of the subfamily Leishmaniinae Maslov et Lukeš in Jirků et al., 2012. Agreeing with erection of the genus Zelonia Shaw, Camargo et Teixeira in Espinosa et al., 2017 and the subgenus Mundinia Shaw, Camargo et Teixeira in Espinosa et al., 2017 within the genus Leishmania Ross, 1908, we argue that other changes are not well justified. We propose to: (i) raise Paraleishmania Cupolillo, Medina-Acosta, Noyes, Momen et Grimaldi, 2000 to generic rank; (ii) create a new genus Borovskyia gen...
July 10, 2017: Folia Parasitologica
https://www.readbyqxmd.com/read/28765094/non-coding-rnas-as-a-new-dawn-in-tumor-diagnosis
#20
REVIEW
Anna Grimaldi, Mayra Rachele Zarone, Carlo Irace, Silvia Zappavigna, Angela Lombardi, Hiromichi Kawasaki, Michele Caraglia, Gabriella Misso
The current knowledge about non-coding RNAs (ncRNAs) as important regulators of gene expression in both physiological and pathological conditions, has been the main engine for the design of innovative platforms to finalize the pharmacological application of ncRNAs as either therapeutic tools or as molecular biomarkers in cancer. Biochemical alterations of cancer cells are, in fact, largely supported by ncRNA disregulation in the tumor site, which, in turn, reflects the cancer-associated specific modification of circulating ncRNA expression pattern...
July 29, 2017: Seminars in Cell & Developmental Biology
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