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https://www.readbyqxmd.com/read/29780930/morpho-functional-evaluation-of-torpedo-maculopathy-with-optical-coherence-tomography-angiography-and-microperimetry
#1
Gabriela Grimaldi, Andrea Scupola, Maria G Sammarco, Michele Marullo, Maria A Blasi
Purpose: To report the case of a 13-year-old girl with torpedo maculopathy, evaluated with multimodal morpho-functional retinal imaging, including fundus photography, infra-red and blue fundus autofluorescence, swept-source optical coherence tomography (OCT), en face OCT, OCT angiography and microperimetry (MP). Observations: On fundus examination, a torpedo-like hypopigmented lesion was observed temporal to the fovea in the left eye. OCT showed disruption of outer retinal layers and the presence of a subretinal cleft...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29769580/kv1-3-activity-perturbs-the-homeostatic-properties-of-astrocytes-in-glioma
#2
Alfonso Grimaldi, Giuseppina D'Alessandro, Maria Amalia Di Castro, Clotilde Lauro, Vikrant Singh, Francesca Pagani, Luigi Sforna, Francesca Grassi, Silvia Di Angelantonio, Luigi Catacuzzeno, Heike Wulff, Cristina Limatola, Myriam Catalano
Glial cells actively maintain the homeostasis of brain parenchyma, regulating neuronal excitability and preserving the physiological composition of the extracellular milieu. Under pathological conditions, some functions of glial cells could be compromised, exacerbating the neurotoxic processes. We investigated if the homeostatic activities of astrocytes and microglia could be modulated by the voltage-gated K+ channel Kv1.3. To this end we used in vitro and in vivo systems to model cell-to-cell interactions in tumoral conditions, using a specific inhibitor of Kv1...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29744353/donation-after-circulatory-death-in-paediatric-liver-transplantation-current-status-and-future-perspectives-in-the-machine-perfusion-era
#3
REVIEW
Roberta Angelico, M Thamara P R Perera, Tommaso Maria Manzia, Alessandro Parente, Chiara Grimaldi, Marco Spada
Efforts have been made by the transplant community to expand the deceased donor pool in paediatric liver transplantation (LT). The growing experience on donation after circulatory death (DCD) for adult LT has encouraged its use also in children, albeit in selective cases, opening new perspectives for paediatric patients. Even though there has recently been a slight increase in the number of DCD livers transplanted in children, with satisfactory graft and patient outcomes, the use of DCD grafts in paediatric recipients is still controversial due to morbid outcomes associated with DCD grafts...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29743509/author-correction-role-of-the-particle-size-polydispersity-in-the-electrical-conductivity-of-carbon-nanotube-epoxy-composites
#4
Maryam Majidian, Claudio Grimaldi, László Forró, Arnaud Magrez
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29742585/cardiac-arrest-in-patients-managed-for-convulsive-status-epilepticus-characteristics-predictors-and-outcome
#5
Stephane Legriel, Edouard Bresson, Nicolas Deye, David Grimaldi, Bertrand Sauneuf, Olivier Lesieur, Jean-Baptiste Lascarrou, Laurent Argaud, Jonathan Chelly, Pascal Beuret, David Schnell, Anne-Laure Chateauneuf, Mathilde Holleville, François Perier, Virginie Lemiale, Cedric Bruel, Pierrick Cronier, Nicolas Pichon, Nicolas Mongardon, Nicolas de-Prost, Florence Dumas, Alain Cariou
OBJECTIVES: Cardiac arrest is a catastrophic event that may arise during the management of convulsive status epilepticus. We aimed to report the clinical characteristics, outcomes, and early predictors of convulsive status epilepticus-related cardiac arrest. DESIGN: Retrospective multicenter study. SETTING: Seventeen university or university affiliated participating ICUs in France and Belgium. PATIENTS: Consecutive patients admitted to the participating ICUs for management of successfully resuscitated out-of-hospital cardiac arrest complicating the initial management of convulsive status epilepticus between 2000 and 2015...
May 8, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29720374/education-plus-exercise-versus-corticosteroid-injection-use-versus-a-wait-and-see-approach-on-global-outcome-and-pain-from-gluteal-tendinopathy-prospective-single-blinded-randomised-clinical-trial
#6
Rebecca Mellor, Kim Bennell, Alison Grimaldi, Philippa Nicolson, Jessica Kasza, Paul Hodges, Henry Wajswelner, Bill Vicenzino
OBJECTIVE: To compare the effects of a programme of load management education plus exercise, corticosteroid injection use, and no treatment on pain and global improvement in individuals with gluteal tendinopathy. DESIGN: Prospective, three arm, single blinded, randomised clinical trial. SETTING: Brisbane and Melbourne, Australia. PARTICIPANTS: Individuals aged 35-70 years, with lateral hip pain for more than three months, at least 4/10 on the pain numerical rating scale, and gluteal tendinopathy confirmed by clinical diagnosis and magnetic resonance imaging; and with no corticosteroid injection use in previous 12 months, current physiotherapy, total hip replacement, or neurological conditions...
May 2, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29716092/selective-coupling-of-whispering-gallery-modes-in-film-coated-micro-resonators
#7
Andrea Barucci, Immacolata Angelica Grimaldi, Gianluca Persichetti, Simone Berneschi, Silvia Soria, Bruno Tiribilli, Romeo Bernini, Francesco Baldini, Gualtiero Nunzi Conti
Whispering Gallery Mode (WGM) micro-resonators like microspheres or microtoroids are typically used as high-Q cavity substrate on which a functional film coating is deposited. In order to exploit the coating properties a critical step is the efficient excitation of WGMs mainly contained inside the deposited layer. We developed a simple method able to assess whether or not these modes are selectively excited. The method is based on monitoring the thermal shift of the excited resonance, which uniquely depends on the thermo-optic coefficient and on the thermal expansion coefficient of the material in which the mode is embedded...
April 30, 2018: Optics Express
https://www.readbyqxmd.com/read/29710564/influence-of-hydroclimatic-variations-on-solute-concentration-dynamics-in-nested-subtropical-catchments-with-heterogeneous-landscapes
#8
REVIEW
Gustavo Antonio Piazza, Rémi Dupas, Chantal Gascuel-Odoux, Catherine Grimaldi, Adilson Pinheiro, Vander Kaufmann
Despite global efforts to monitor water quality in catchments worldwide, tropical and subtropical zones still lack data to study the influence of human activities and climate variations on solute dynamics. In this study, we monitored ten solutes every two weeks for six years (2010-2015) in three nested catchments (2 to30 km2 ), which contained heterogeneous landscapes composed of forests and agricultural land, and one small neighboring forested catchment (0.4 km2 ). Data analysis revealed that i) rainfall, discharge and solute concentrations displayed no clear seasonal patterns, unlike many catchments of the temperate zone; ii) solute concentrations in the agricultural area were higher than those in the forested area, but both areas displayed similar temporal patterns due to a common hydroclimatic driver; iii) all four catchments displayed a chemostatic export regime for most of the solutes, similar to catchments of the temperate zone; and iv) a positive correlation was observed between anion concentrations and ENSO (El Niño-Southern Oscillation) index...
April 20, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29701456/clickable-zwitterionic-co-polymer-capped-quantum-dots-for-in-vivo-fluorescence-tumor-imaging
#9
Laura Trapiella-Alfonso, Thomas Pons, Nicolas Lequeux, Ludovic Leleu, Juliette Grimaldi, Mariana Tasso, Edward Oujagir, Johanne Seguin, Fanny d'Orlyé, Christian Girard, Bich-Thuy Doan, Anne Varenne
In the last decades, fluorescent quantum dots have appeared as high-performance biological fluorescent nanoprobes and have been explored for a variety of biomedical optical imaging applications. However many central challenges still exist concerning the control of the surface chemistry in order to ensure high biocompatibility, low toxicity, anti-fouling and specific active targeting properties. Regarding in vivo applications, circulation time and clearance of the nanoprobe are also key parameters to control for the design and characterization of new optical imaging agents...
April 27, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29696443/relationship-between-functional-imaging-and-immunohistochemical-markers-and-prediction-of-breast-cancer-subtype-a-pet-mri-study
#10
Mariarosaria Incoronato, Anna Maria Grimaldi, Carlo Cavaliere, Marianna Inglese, Peppino Mirabelli, Serena Monti, Umberto Ferbo, Emanuele Nicolai, Andrea Soricelli, Onofrio Antonio Catalano, Marco Aiello, Marco Salvatore
PURPOSE: The aim of this study was to determine if functional parameters extracted from the hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) correlate with the immunohistochemical markers of breast cancer (BC) lesions, to assess their ability to predict BC subtype. METHODS: This prospective study was approved by the institution's Ethics Committee, and all patients provided written informed consent. A total of 50 BC patients at diagnosis underwent PET/MRI before pharmacological and surgical treatment...
April 25, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29693574/liver-transplantation-and-gut-microbiota-profiling-in-a-child-colonized-by-a-multi-drug-resistant-klebsiella-pneumoniae-a-new-approach-to-move-from-antibiotic-to-eubiotic-control-of-microbial-resistance
#11
Federica Del Chierico, Sabrina Cardile, Andrea Pietrobattista, Daniela Liccardo, Alessandra Russo, Manila Candusso, Maria Sole Basso, Chiara Grimaldi, Laura Pansani, Paola Bernaschi, Giuliano Torre, Lorenza Putignani
The increase of microorganisms multi-drug resistant (MDR) to antibiotics (ATBs) is becoming a global emergency, especially in frail subjects. In chronic liver disease (LD) with indications for liver transplantation (LT), MDR colonization can significantly affect the LT outcome. However, no clear guidelines for microbial management are available. A novel approach toward MDR-colonized patients undergoing LT was developed at our Center refraining from ATBs use during the transplant waiting list, and use of an intensive perioperative prophylaxis cycle...
April 25, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29692922/-18-f-fdopa-pet-mri-for-monitoring-early-response-to-bevacizumab-in-children-with-recurrent-brain-tumors
#12
Karen Gauvain, Maria Rosana Ponisio, Amy Barone, Michael Grimaldi, Ephraim Parent, Hayden Leeds, Manu Goyal, Joshua Rubin, Jonathan McConathy
Background: Noninvasively predicting early response to therapy in recurrent pediatric brain tumors provides a challenge. 3,4-dihydroxy-6-[18 F]fluoro-L-phenylalanine (18 F-FDOPA) PET/MRI has not been previously studied as a tool to evaluate early response to antiangiogenic therapy in children. The purpose of this study was to evaluate the safety and feasibility of using 18 F-FDOPA PET/MRI to assess response to bevacizumab in children with relapsed brain tumors. Materials and Methods: Six patients with recurrent gliomas (5 low-grade, 1 high-grade) planned to undergo treatment with bevacizumab were enrolled...
March 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29690278/remarkable-fly-diptera-diversity-in-a-patch-of-costa-rican-cloud-forest-why-inventory-is-a-vital-science
#13
Art Borkent, Brian V Brown, Peter H Adler, Dalton de Souza Amorim, Kevin Barber, Daniel Bickel, Stephanie Boucher, Scott E Brooks, John Burger, Z L Burington, Renato S Capellari, Daniel N R Costa, Jeffrey M Cumming, Greg Curler, Carl W Dick, J H Epler, Eric Fisher, Stephen D Gaimari, Jon Gelhaus, David A Grimaldi, John Hash, Martin Hauser, Heikki Hippa, Sergio IbÁÑez-Bernal, Mathias Jaschhof, Elena P Kameneva, Peter H Kerr, Valery Korneyev, Cheslavo A Korytkowski, Giar-Ann Kung, Gunnar Mikalsen Kvifte, Owen Lonsdale, Stephen A Marshall, Wayne N Mathis, Verner Michelsen, Stefan Naglis, Allen L Norrbom, Steven Paiero, Thomas Pape, Alessandre Pereira-Colavite, Marc Pollet, Sabrina Rochefort, Alessandra Rung, Justin B Runyon, Jade Savage, Vera C Silva, Bradley J Sinclair, Jeffrey H Skevington, John O Iii Stireman, John Swann, Pekka Vilkamaa, Terry Wheeler, Terry Whitworth, Maria Wong, D Monty Wood, Norman Woodley, Tiffany Yau, Thomas J Zavortink, Manuel A Zumbado
Study of all flies (Diptera) collected for one year from a four-hectare (150 x 266 meter) patch of cloud forest at 1,600 meters above sea level at Zurquí de Moravia, San José Province, Costa Rica (hereafter referred to as Zurquí), revealed an astounding 4,332 species. This amounts to more than half the number of named species of flies for all of Central America. Specimens were collected with two Malaise traps running continuously and with a wide array of supplementary collecting methods for three days of each month...
March 27, 2018: Zootaxa
https://www.readbyqxmd.com/read/29680989/challenging-pre-surgical-localization-of-hyperfunctioning-parathyroid-glands-in-primary-hyperparathyroidism-the-added-value-of-18-f-fluorocholine-pet-ct
#14
Serena Grimaldi, Jacques Young, Peter Kamenicky, Dana Hartl, Marie Terroir, Sophie Leboulleux, Amandine Berdelou, Julien Hadoux, Segolene Hescot, Hervé Remy, Eric Baudin, Martin Schlumberger, Désirée Deandreis
PURPOSE: To evaluate the added value of 18 F-Fluorocholine (18 F-FCH) PET/CT in presurgical imaging of patients with primary hyperparathyroidism (HPT) and challenging localization of the hyper-functioning parathyroid glands. METHODS: We included 27 consecutive patients with primary HPT (19 F; median age: 58 years), with either (i) non-conclusive pre-surgical localization with 99 mTc-sestaMIBI scintigraphy and neck ultrasonography (US), (ii) recurrence of previously operated HPT, or (iii) familiar HPT with a suspicion of multiple gland disease...
April 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29667071/optimizing-cardiac-resynchronization-therapy-an-update-on-new-insights-and-advancements
#15
REVIEW
Adam Grimaldi, Eiran Z Gorodeski, John Rickard
PURPOSE OF REVIEW: This review focuses on the current advancements in optimizing patient response to cardiac resynchronization therapy (CRT). RECENT FINDINGS: It has been well known that not every patient will derive benefit from CRT, and of those that do, there are varying levels of response. Optimizing CRT begins well before device implant and involves appropriate patient selection and an understanding of the underlying substrate. After implant, there are different CRT device programming options that can be enabled to help overcome barriers as to why a patient may not respond...
June 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29664600/asymmetric-optical-transitions-determine-the-onset-of-carrier-multiplication-in-lead-chalcogenide-quantum-confined-and-bulk-crystals
#16
Frank C M Spoor, Gianluca Grimaldi, Christophe Delerue, Wiel H Evers, Ryan W Crisp, Pieter Geiregat, Zeger Hens, Arjan J Houtepen, Laurens D A Siebbeles
Carrier multiplication is a process in which one absorbed photon excites two or more electrons. This is of great promise to increase the efficiency of photovoltaic devices. Until now, the factors that determine the onset energy of carrier multiplication have not been convincingly explained. We show experimentally that the onset of carrier multiplication in lead chalcogenide quantum confined and bulk crystals is due to asymmetric optical transitions. In such transitions most of the photon energy in excess of the band gap is given to either the hole or the electron...
April 17, 2018: ACS Nano
https://www.readbyqxmd.com/read/29628278/left-atrial-dilatation-a-target-organ-damage-in-young-to-middle-age-hypertensive-patients-the-campania-salute-network
#17
Costantino Mancusi, Grazia Canciello, Raffaele Izzo, Silvia Damiano, Maria Gabriella Grimaldi, Nicola de Luca, Giovanni de Simone, Bruno Trimarco, Maria-Angela Losi
BACKGROUND: Left atrial (LA) volume is a predictor of outcome in hypertension. It is unclear whether or not this effect depends on coexisting target organ damage (TOD). PURPOSE: To investigate whether LA volume predicts outcome independently of TOD [left ventricular (LV) hypertrophy (LVH) and/or carotid plaque] in a registry of hypertensive treated patients. METHODS: From the Campania Salute Network registry, we selected 5844 young adult hypertensive patients <65 years old (mean age 50 ± 9 years, 41% women, 8% diabetic) without prevalent CV or valvular heart disease more than mild, with normal LV ejection fraction, stage III or less CKD and available follow-up...
March 27, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29621713/analysis-of-endocrine-activity-in-drinking-water-surface-water-and-treated-wastewater-from-six-countries
#18
Frederic D L Leusch, Peta A Neale, Charlotte Arnal, Natalie H Aneck-Hahn, Patrick Balaguer, Auguste Bruchet, Beate I Escher, Mar Esperanza, Marina Grimaldi, Gaela Leroy, Marco Scheurer, Rita Schlichting, Merijn Schriks, Armelle Hebert
The aquatic environment can contain numerous micropollutants and there are concerns about endocrine activity in environmental waters and the potential impacts on human and ecosystem health. In this study a complementary chemical analysis and in vitro bioassay approach was applied to evaluate endocrine activity in treated wastewater, surface water and drinking water samples from six countries (Germany, Australia, France, South Africa, the Netherlands and Spain). The bioassay test battery included assays indicative of seven endocrine pathways, while 58 different chemicals, including pesticides, pharmaceuticals and industrial compounds, were analysed by targeted chemical analysis...
March 27, 2018: Water Research
https://www.readbyqxmd.com/read/29615901/isoquercetin-as-an-adjunct-therapy-in-patients-with-kidney-cancer-receiving-first-line-sunitinib-quasar-results-of-a-phase-i-trial
#19
Carlo Buonerba, Pietro De Placido, Dario Bruzzese, Martina Pagliuca, Paola Ungaro, Davide Bosso, Dario Ribera, Simona Iaccarino, Luca Scafuri, Antonietta Liotti, Valeria Romeo, Michela Izzo, Francesco Perri, Beniamino Casale, Giuseppe Grimaldi, Francesca Vitrone, Arturo Brunetti, Daniela Terracciano, Alfredo Marinelli, Sabino De Placido, Giuseppe Di Lorenzo
Sunitinib is the most commonly prescribed drug for advanced renal cell carcinoma in the first-line setting and has been associated with multiple adverse events related to its on-and off-target effects, including hand and foot syndrome and fatigue. It was hypothesized that sunitinib-induced fatigue may be related to off target inhibition of the AMPK enzyme, which results in impairment of energy-producing processes at a systemic level. Quercetin is a naturally occurring flavonol with established AMPK-stimulating activity...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29606464/delaying-fat-bloom-formation-in-dark-chocolate-by-adding-sorbitan-monostearate-or-cocoa-butter-stearin
#20
Monise Helen Masuchi Buscato, Larissa Miho Hara, Élida Castilho Bonomi, Guilherme de Andrade Calligaris, Lisandro Pavie Cardoso, Renato Grimaldi, Theo Guenter Kieckbusch
Two formulations of dark chocolate were developed by adding cocoa butter stearin (CBSt) or sorbitan monostearate (SMS) and compared to a standard formulation in order to investigate fat bloom formation over time. Fat bloom was monitored by Whiteness Index (WI), melting behavior and polymorphism determinations, in bars stored during 90 days at 20 °C and under oscillating temperature between 20 and 32 °C. All samples stored at 20 °C did not develop fat bloom and the required β(V) form was maintained...
August 1, 2018: Food Chemistry
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