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https://www.readbyqxmd.com/read/29775916/cortisol-trajectory-melancholia-and-response-to-electroconvulsive-therapy
#1
Brian J Mickey, Yarden Ginsburg, Adam F Sitzmann, Clara Grayhack, Srijan Sen, Clemens Kirschbaum, Daniel F Maixner, James L Abelson
While biomarkers have been used to define pathophysiological types and to optimize treatment in many areas of medicine, in psychiatry such biomarkers remain elusive. Based on previously described abnormalities of hypothalamic-pituitary-adrenal (HPA) axis function in severe forms of depression, we hypothesized that the temporal trajectory of basal cortisol levels would vary among individuals with depression due to heterogeneity in pathophysiology, and that cortisol trajectories that reflect elevated or increasing HPA activity would predict better response to electroconvulsive therapy (ECT)...
May 15, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29773014/investigations-of-phytochemical-constituents-and-their-pharmacological-properties-isolated-from-the-genus-urtica-critical-review-and-analysis
#2
Muhammad Ibrahim, Kanwal Rehman, Aneeza Razzaq, Iqbal Hussain, Tahir Farooq, Amjad Hussain, Muhammad Sajid Hamid Akash
The genus Urtica belongs to the family Urticaceae. The plants of this genus are known as nettles or, quite often, as stinging nettles. These plants can be easily identified by the presence of stinging hairs. Urtica species have previously been used for various medicinal purposes. The history for the use of these plants for medicinal purposes starts from the Bronze Age (3000-2000 BC). Medicinally, the genus Urtica has been used to treat several disorders, such as cancer, rheumatoid arthritis, bronchitis, diarrhea, sprains, kidney stones, urinary tract infection, high blood pressure, hemorrhoids, flu, cough, fever, and ulcers...
2018: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29769783/trichotillomania-ranging-from-ritual-to-illness-and-as-a-rare-clinical-manifestation-of-frontotemporal-dementia-review-of-literature-and-case-report
#3
Thomas Gregor Issac, Ashay Vivek Telang, Sadanandavalli Retnaswami Chandra
Frontotemporal dementia (FTD) is the most common form of dementia in the younger age group and often exists with comorbid obsessions and compulsions in up to 80% of the patients. Trichotillomania or compulsive "hair-pulling" disorder is a rare manifestation of FTD and is a poorly evaluated symptom in this condition. The release of "grooming functions" due to frontal disinhibition is often attributed to the evolutionary perspective; however, recent findings also implicate the role of neurotransmitter dysfunction...
March 2018: International Journal of Trichology
https://www.readbyqxmd.com/read/29769265/reciprocal-negative-regulation-between-lmx1a-and-lmo4-is-required-for-inner-ear-formation
#4
Yanhan Huang, Jennifer Hill, Andrew Yatteau, Loksum Wong, Tao Jiang, Jelena Petrovic, Lin Gan, Lijin Dong, Doris K Wu
LIM-domain containing transcription factors (LIM-TFs) are conserved factors important for embryogenesis. The specificity of these factors in transcriptional regulation is conferred by the complexes they form with other proteins such as LIM-domain-binding (Ldb) proteins and LIM-domain only (LMO) proteins. Unlike LIM-TF, these proteins do not bind DNA directly. LMO are negative regulators of LIM-TF and they function by competing with LIM-TFs for binding to Ldbs. Although the LIM-TF Lmx1a is expressed in the developing mouse hindbrain, which provides many of the extrinsic signals for inner ear formation, conditional knockout embryos of both sexes show that the inner ear source of Lmx1a is the major contributor of ear patterning...
May 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29757849/ocular-surface-findings-in-patients-with-lichen-planopilaris
#5
Mehdi Gheisari, Sahar Dadkhahfar, Kaveh Fadakar, Reza Mahmoud Robati, Hamideh Moravvej, Mohammad Soleimani, Reza Mirshahi
PURPOSE: Lichen planopilaris (LPP) is a chronic lymphocytic- mediated disorder that selectively involves hair follicles, leading to cicatricial alopecia. The eyelash follicle and meibomian gland (MG) might also be involved in the disease process leading to ocular surface problems. METHODS: In this Cross-sectional case -control study, twenty-three patients with histologically confirmed LPP and 23 healthy controls were recruited in this controlled study. To quantify the signs and symptoms of LPP, we used the Lichen Planopilaris Activity Index...
May 10, 2018: Cornea
https://www.readbyqxmd.com/read/29751043/tauroursodeoxycholic-acid-attenuates-gentamicin-induced-cochlear-hair-cell-death-in-vitro
#6
Zhanwei Jia, Qiang He, Chunguang Shan, Fengyi Li
Gentamycin is one of the most clinically used aminoglycoside antibiotics which induce intrinsic apoptosis of hair cells. Tauroursodeoxycholic acid (TUDCA) is known as safe cell-protective agent in disorders associated with apoptosis. We aimed to investigate the protective effects of TUDCA against gentamicin-induced ototoxicity. House Ear Institute-Organ of Corti 1(HEI-OC1) cells and explanted cochlear tissue were treated with gentamicin and TUDCA, followed by serial analyses including cell viability assay, hair cell staining, qPCR, ELISA and western blotting to determine the cell damage by the parameters relevant to cell apoptosis and endoplasmic reticulum stress...
May 8, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29744913/cartilage-hair-hypoplasia-with-cutaneous-lymphomatoid-granulomatosis
#7
D Sathishkumar, J E Gach, M Ogboli, M Desai, T Cole, W Högler, J Motwani, A Norton, B Morland, I Colmenero
Cartilage-hair hypoplasia (CHH) is an autosomal recessive chondrodysplasia characterized by short-stature, sparse hair and impaired cellular immunity. We describe a young girl who was diagnosed with CHH based on the findings of recurrent infections, short stature with metaphyseal chondrodysplasia, and a confirmed bi-allelic RMRP gene mutation. At 13 years, the patient developed an Epstein-Barr virus (EBV)-driven lymphoproliferative disorder involving the lung, which responded partially to chemotherapy. Simultaneously, she developed multiple indurated plaques involving her face, which had histological findings of granulomatous inflammation and EBV-associated low-grade lymphomatoid granulomatosis...
May 10, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29744570/alopecia-universalis-in-a-patient-with-rheumatoid-arthritis-developed-during-treatment-with-adalimumab
#8
P Ostojic, S Pavlov-Dolijanovic
Alopecia universalis is an advanced form of alopecia areata, characterized by complete loss of hair on all hair-bearing areas. It is currently believed to be an autoimmune disorder. The development of alopecia during treatment with tumor necrosis factor alpha (TNF-α) inhibitors is a rarely observed adverse event. This case describes a 56-year-old female patient with rheumatoid arthritis (RA), who developed alopecia universalis during treatment with adalimumab. There was no improvement in alopecia despite withdrawal of adalimumab...
May 9, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29742977/the-thyroid-hormone-receptors-regulate-the-expression-of-micrornas-with-key-roles-in-skin-homeostasis
#9
Lidia Ruiz-Llorente, Constanza Contreras-Jurado, Mónica Martínez-Fernández, Jesus Maria Paramio, Ana Aranda
BACKGROUND: MicroRNAs (miRNAs) play a unique role in posttranscriptional regulation of gene expression and control different aspects of skin development, homeostasis and disease. Although it is generally accepted that thyroid hormones signaling is important in skin pathophysiology, the role of their nuclear receptors (TRs) in cutaneous miRNA expression has yet to be explored. METHODS: We have used RNAseq to compare the skin miRnome of wild-type mice and genetically modified mice lacking both TRα1 and TRβ, the main thyroid hormone binding isoforms...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29738529/identifying-novel-strategies-for-treating-human-hair-loss-disorders-cyclosporine-a-suppresses-the-wnt-inhibitor-sfrp1-in-the-dermal-papilla-of-human-scalp-hair-follicles
#10
Nathan J Hawkshaw, Jonathan A Hardman, Iain S Haslam, Asim Shahmalak, Amos Gilhar, Xinhong Lim, Ralf Paus
Hair growth disorders often carry a major psychological burden. Therefore, more effective human hair growth-modulatory agents urgently need to be developed. Here, we used the hypertrichosis-inducing immunosuppressant, Cyclosporine A (CsA), as a lead compound to identify new hair growth-promoting molecular targets. Through microarray analysis we identified the Wnt inhibitor, secreted frizzled related protein 1 (SFRP1), as being down-regulated in the dermal papilla (DP) of CsA-treated human scalp hair follicles (HFs) ex vivo...
May 2018: PLoS Biology
https://www.readbyqxmd.com/read/29737035/systemic-lupus-erythematosus-in-a-patient-with-noonan-syndrome-like-disorder-with-loose-anagen-hair-1-more-than-a-chance-association
#11
Tomoko Uehara, Naoki Hosogaya, Nobutake Matsuo, Kenjiro Kosaki
Systemic lupus erythematosus (SLE) has been reported among patients with RASopathy. Five patients have been reported: three with SHOC2 variants, one with a PTPN11 variant, and one with a KRAS variant. SHOC2 variant might represent a relatively common predisposing factor for SLE among the RASopathy genes. However, the clinical details were only reported for two patients, while information on the remaining patient appeared only in a tabular format with minimal clinical description. Here, we report a patient with a SHOC2 variant and SLE...
May 7, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29735969/contralateral-electroacupuncture-relieves-chronic-neuropathic-pain-in-rats-with-spared-nerve-injury
#12
Haolin Zhang, Jungang Sun, Xiyan Xin, Zejun Huo, Dong Li
BACKGROUND Acupuncture and electroacupuncture (EA) are widely applied in the treatment of various conditions, including pain. Acupuncture stimulation is applied not only in areas close to pain sites, but also in distal regions or on the contralateral side of the body. Identifying which acupuncture paradigms produce best therapeutic effects is of clinical significance. MATERIAL AND METHODS Spared nerve injury (SNI) was applied to establish a rat model of neuropathic pain. We applied 14 sessions of EA (BL 60 and BL 40, 1-2 mA, and 2 Hz, 30 min per session) every other day from days 3 to 29 after surgery on the contralateral or ipsilateral side of pain...
May 8, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29734102/low-doses-of-methylmercury-intoxication-solely-or-associated-to-ethanol-binge-drinking-induce-psychiatric-like-disorders-in-adolescent-female-rats
#13
Ivaldo Jesus Almeida Belém-Filho, Paula Cardoso Ribera, Aline Lima Nascimento, Antônio Rafael Quadros Gomes, Rafael Rodrigues Lima, Maria Elena Crespo-Lopez, Marta Chagas Monteiro, Enéas Andrade Fontes-Júnior, Marcelo Oliveira Lima, Cristiane Socorro Ferraz Maia
Methylmercury (MeHg) is an environmental contaminant that provokes damage to developing brain. Simultaneously, the consumption of ethanol among adolescents has increased. Evidence concerning the effects of MeHg low doses per se or associated with ethanol during adolescence are scarce. Thus, we investigate behavioral disorders resulted from exposure to MeHg low doses and co-intoxicated with ethanol in adolescent rats. Wistar rats received chronic exposure to low doses of MeHg (40 μg/kg/day for 5 weeks) and/or ethanol binge drinking (3 g/kg/day at 3 days per week for 5 weeks)...
April 30, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29723381/the-tendency-towards-the-development-of-psychosexual-disorders-in-androgenetic-alopecia-according-to-the-different-stages-of-hair-loss-a-cross-sectional-study
#14
Betul Tas, Filiz Kulacaoglu, Hasan Belli, Murat Altuntas
BACKGROUND: Androgenetic alopecia is a common dermatological condition affecting both genders. OBJECTIVE: To evaluate the tendency towards development of psychosexual disorders according to the clinical stages of androgenetic alopecia. METHODS: A cross-sectional study was conducted including 353 patients of both sexes on different clinical stages of hair loss, and the patients were enquired about self-perception, self-esteem, sexual experiences, anxiety and depression states...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29716882/vacuolization-in-myeloid-and-erythroid-precursors-in-a-child-with-menkes-disease
#15
Seçil Sayın, Şule Ünal, Mualla Cetin, Fatma Gumruk
A five year-old boy, who was under follow-up with a clinical and biochemical diagnosis of Menkes Disease (MD) since ten months of age, was admitted with diarrhea. On examination he had a characteristic cherubic face hypopigmented, sparse hair, hepatosplenomegaly, hypotonia with brisk deep tendon reflexes. Hemogram revealed: Hb:5.5g/dL, Hct:16.2%, RBC:1.69x1012/L, MCV:95.8fL, MCH:32.3pg, RDW:19.2%, WBC:2.2x109/L and platelet count;157x109/L. Serum vitamin B12 level was 575pg/mL. Serum copper level was 81μg/dL and serum zinc level was 152μg/dL...
April 30, 2018: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/29713847/stimulation-of-mouse-vibrissal-follicle-growth-by-recombinant-human-fibroblast-growth-factor-20
#16
Xue-Gang Xu, Lin Gong, Tian-Ling Jiang, Yuan-Hong Li, Xing-Hua Gao, Haishan Tian, Hong-Duo Chen
OBJECTIVES: To explore potential effects of recombinant human fibroblast growth factor 20 (rhFGF20) in the growth of cultured mouse vibrissal follicles. RESULTS: The growth of cultured mouse vibrissal follicles was significantly induced by rhFGF20 in a dose dependent pattern in the in vitro vibrissal follicle organ culture model. However, too high concentration of rhFGF20 could inhibit the growth of vibrissal follicles. We further demonstrated that rhFGF20 stimulated the proliferation of hair matrix cells and activated Wnt/β-catenin signaling pathway...
April 30, 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29709849/sources-behaviour-and-environmental-and-human-health-risks-of-high-technology-rare-earth-elements-as-emerging-contaminants
#17
REVIEW
Willis Gwenzi, Lynda Mangori, Concilia Danha, Nhamo Chaukura, Nothando Dunjana, Edmond Sanganyado
Recent studies show that high-technology rare earth elements (REEs) of anthropogenic origin occur in the environment including in aquatic systems, suggesting REEs are contaminants of emerging concern. However, compared to organic contaminants, there is a lack of comprehensive reviews on the anthropogenic sources, environmental behaviour, and public and ecological health risks of REEs. The current review aims to: (1) identify anthropogenic sources, transfer mechanisms, and environmental behaviour of REEs; (2) highlight the human and ecological health risks of REEs and propose mitigation measures; and (3) identify knowledge gaps and future research directions...
April 26, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29696047/comparison-of-cochlear-microphonics-magnitude-with-broad-and-narrow-band-stimuli-in-healthy-adult-wistar-rats
#18
Fatemeh Heidari Phd, Akram Pourbakht, Seyed Kamran Kamrava, Mohammad Kamali, Abbas Yousefi
Objective: Cochlear microphonic (CM) is a cochlear AC electric field, recorded within, around, and remote from its sources. Nowadays it can contribute to the differential diagnosis of different auditory pathologies such as auditory neuropathy spectrum disorder (ANSD). This study compared CM waveforms (CMWs) and amplitudes with broad and narrow band stimuli in 25 healthy male young adults Wistar rats. Materials & Methods: This experimental study was accomplished in the School of Rehabilitation Sciences of Iran University of Medical Sciences, Tehran, Iran (April, 2016)...
2018: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/29692463/vitamin-d-dependent-rickets-type-ii-with-alopecia-a-rare-case-report
#19
Divya Vupperla, Snehal Balvant Lunge, Praveen Elaprolu
Vitamin D-dependent rickets type II is a rare hereditary disorder. It occurs due to mutations in the gene chr. 12q12-q14, which codes for vitamin D receptor. End-organ resistance to 1,25-(OH)2 vitamin D3 and alopecia in severe cases are the characteristic features. We report a case of a 4-year-old boy with loss of hair over the scalp and body - first observed after 1 month of birth. The boy also developed difficulty in walking at the age of 2 year. On analysis, reduced serum calcium level (7.5 mg/dL) and elevated alkaline phosphatase level (625 IU/L) were reported...
March 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29688570/diffuse-large-b-cell-lymphoma-chemotherapy-reveals-a-combined-immunodeficiency-syndrome-in-cartilage-hair-hypoplasia
#20
Alexandre Nguyen, Nicolas Martin Silva, Hubert de Boysson, Gandhi Damaj, Achille Aouba
Cartilage hair hypoplasia (CHH) is a rare autosomal recessive ribosomopathy characterised by skeletal and integumentary system manifestations. It may also present with varied forms and intensities of haematopoietic and/or immune disorders. We report a 27-year-old female who presented a picture of combined immunodeficiency after receiving an adriamycin-based chemotherapy regimen followed by autologous stem cell transplantation. Her medical history indicated neonatal dwarfism, recurrent ear, nose and throat and respiratory infections, and hypogammaglobulinaemia, which were suggestive of a primary minor B-cell immune deficiency...
April 24, 2018: Swiss Medical Weekly
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