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Burkholderia cenocepacia

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https://www.readbyqxmd.com/read/29906254/broad-spectrum-antimicrobial-activity-by-burkholderia-cenocepacia-tatl-371-a-strain-isolated-from-the-tomato-rhizosphere
#1
Fernando Uriel Rojas-Rojas, Anuar Salazar-Gómez, María Elena Vargas-Díaz, María Soledad Vásquez-Murrieta, Ann M Hirsch, René De Mot, Maarten G K Ghequire, J Antonio Ibarra, Paulina Estrada-de Los Santos
The Burkholderia cepacia complex (Bcc) comprises a group of 24 species, many of which are opportunistic pathogens of immunocompromised patients and also are widely distributed in agricultural soils. Several Bcc strains synthesize strain-specific antagonistic compounds. In this study, the broad killing activity of B. cenocepacia TAtl-371, a Bcc strain isolated from the tomato rhizosphere, was characterized. This strain exhibits a remarkable antagonism against bacteria, yeast and fungi including other Bcc strains, multidrug-resistant human pathogens and plant pathogens...
June 15, 2018: Microbiology
https://www.readbyqxmd.com/read/29897328/insights-into-the-genome-diversity-and-virulence-of-two-clinical-isolates-of-burkholderia-cenocepacia
#2
Tamara Salloum, Elie Nassour, George F Araj, Edmond Abboud, Sima Tokajian
PURPOSE: Burkholderia cenocepacia is among the most common members of the Burkholderia cepacia complex (Bcc) isolated from patients with cystic fibrosis (CF). The factors triggering the high rates of morbidity and mortality in CF patients are not well elucidated. In this study, we aim to highlight the genome diversity of two clinical isolates of B. cenocepacia through comparative genome analysis. METHODOLOGY: The repertoire of virulence factors and resistance genes compared to reference strains J2315 and K56-2 was elucidated...
June 13, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29896180/genetic-determinants-associated-with-in-vivo-survival-of-burkholderia-cenocepacia-in-the-caenorhabditis-elegans-model
#3
Yee-Chin Wong, Moataz Abd El Ghany, Raeece N M Ghazzali, Soon-Joo Yap, Chee-Choong Hoh, Arnab Pain, Sheila Nathan
A Burkholderia cenocepacia infection usually leads to reduced survival and fatal cepacia syndrome in cystic fibrosis patients. The identification of B. cenocepacia essential genes for in vivo survival is key to designing new anti-infectives therapies. We used the Transposon-Directed Insertion Sequencing (TraDIS) approach to identify genes required for B. cenocepacia survival in the model infection host, Caenorhabditis elegans . A B. cenocepacia J2315 transposon pool of ∼500,000 mutants was used to infect C...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29857552/-burkholderia-cenocepacia-prophages-prevalence-chromosome-location-and-major-genes-involved
#4
Bartosz Roszniowski, Siobhán McClean, Zuzanna Drulis-Kawa
Burkholderia cenocepacia , is a Gram-negative opportunistic pathogen that belongs to Burkholderia cepacia complex (BCC) group. BCC representatives carry various pathogenicity factors and can infect humans and plants. Phages as bacterial viruses play a significant role in biodiversity and ecological balance in the environment. Specifically, horizontal gene transfer (HGT) and lysogenic conversion (temperate phages) influence microbial diversification and fitness. In this study, we describe the prevalence and gene content of prophages in 16 fully sequenced B...
May 31, 2018: Viruses
https://www.readbyqxmd.com/read/29850514/-burkholderia-cenocepacia-induces-macropinocytosis-to-enter-macrophages
#5
Roberto Rosales-Reyes, Concepción Sánchez-Gómez, Vianney Ortiz-Navarrete, José Ignacio Santos-Preciado
Burkholderia cenocepacia is an opportunistic pathogen that infects individuals with cystic fibrosis, chronic granulomatous disease, and other immunocompromised states. B. cenocepacia survives in macrophages in membrane-bound vacuoles; however, the mechanism by which B. cenocepacia gains entry into macrophages remains unknown. After macrophage internalization, survival of B. cenocepacia within a bacteria-containing membrane vacuole (BcCV) is associated with its ability to arrest the maturation of the BcCV. In this study, we show that B...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29665015/the-bacterium-pseudomonas-aeruginosa-senses-and-gradually-responds-to-inter-specific-competition-for-iron
#6
Anne Leinweber, Michael Weigert, Rolf Kümmerli
Phenotypic plasticity in response to competition is a well-described phenomenon in higher organisms. Here, we show that also bacteria have the ability to sense the presence of competitors and mount fine-tuned responses to match prevailing levels of competition. In our experiments, we studied inter-specific competition for iron between the bacterium Pseudomonas aeruginosa (PA) and its competitor Burkholderia cenocepacia (BC). We focused on the ability of PA to phenotypically adjust the production of pyoverdine, an iron-scavenging siderophore...
April 17, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29661867/triclosan-is-an-aminoglycoside-adjuvant-for-eradication-of-pseudomonas-aeruginosa-biofilms
#7
Michael M Maiden, Alessandra M Agostinho Hunt, Mitchell P Zachos, Jacob A Gibson, Martin E Hurwitz, Martha H Mulks, Christopher M Waters
One of the most important clinical obstacles in cystic fibrosis (CF) treatment is antibiotic treatment failure due to biofilms produced by Pseudomonas aeruginosa The ability of this pathogen to survive eradication by tobramycin and pathoadapt into a hyperbiofilm state leading to chronic infections is key to its success. Retrospective studies have demonstrated that preventing this pathoadaptation by improving eradication is essential to extend the lives of CF patients. To identify adjuvants that enhance tobramycin eradication of P...
June 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29602945/biosynthesis-of-fragin-is-controlled-by-a-novel-quorum-sensing-signal
#8
Christian Jenul, Simon Sieber, Christophe Daeppen, Anugraha Mathew, Martina Lardi, Gabriella Pessi, Dominic Hoepfner, Markus Neuburger, Anthony Linden, Karl Gademann, Leo Eberl
Members of the diazeniumdiolate class of natural compounds show potential for drug development because of their antifungal, antibacterial, antiviral, and antitumor activities. Yet, their biosynthesis has remained elusive to date. Here, we identify a gene cluster directing the biosynthesis of the diazeniumdiolate compound fragin in Burkholderia cenocepacia H111. We provide evidence that fragin is a metallophore and that metal chelation is the molecular basis of its antifungal activity. A subset of the fragin biosynthetic genes is involved in the synthesis of a previously undescribed cell-to-cell signal molecule, valdiazen...
March 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29559964/comparative-genomics-of-environmental-and-clinical-burkholderia-cenocepacia-strains-closely-related-to-the-highly-transmissible-epidemic-et12-lineage
#9
Josselin Bodilis, Elodie Denet, Elisabeth Brothier, Arnault Graindorge, Sabine Favre-Bonté, Sylvie Nazaret
The Burkholderia cenocepacia epidemic ET12 lineage belongs to the genomovar IIIA including the reference strain J2315, a highly transmissible epidemic B. cenocepacia lineage. Members of this lineage are able to cause lung infections in immunocompromised and cystic fibrosis patients. In this study, we describe the genome of F01, an environmental B. cenocepacia strain isolated from soil in Burkina Faso that is, to our knowledge, the most closely related strain to this epidemic lineage. A comparative genomic analysis was performed on this new isolate, in association with five clinical and one environmental B...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29559421/in-vitro-antimicrobial-activity-of-ceftolozane-tazobactam-against-p-aeruginosa-and-other-non-fermenting-gram-negative-organisms-in-adults-with-cystic-fibrosis
#10
A Gramegna, B C Millar, F Blasi, J S Elborn, D G Downey, J E Moore
INTRODUCTION: Pulmonary exacerbations in people with Cystic Fibrosis (CF), with chronic Gram-negative pathogens, are associated with reduced survival. These pathogens are usually treated with repeated courses of systemic antibiotics. However there is a linked emergence of multidrug resistant (MDR) pathogens. Ceftolozane/tazobactam is a new cephalosporin/beta-lactamase inhibitor combination that has been demonstrated to have good activity against MDR Pseudomonas aeruginosa. MATERIAL & METHODS: In this study ceftolozane/tazobactam was compared to other commonly used intravenous antibiotics against 193 non-fermenting Gram-negative bacteria isolated from CF sputum specimens, including P...
March 17, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29541628/a-c-di-gmp-modulating-protein-regulates-swimming-motility-of-burkholderia-cenocepacia-in-response-to-arginine-and-glutamate
#11
Brijesh Kumar, John L Sorensen, Silvia T Cardona
Burkholderia cenocepacia is an opportunistic bacterium that can thrive in different environments, including the amino acid-rich mucus of the cystic fibrosis (CF) lung. B. cenocepacia responds to the nutritional conditions that mimic the CF sputum by increasing flagellin expression and swimming motility. Individual amino acids also induce swimming but not flagellin expression. Here, we show that modulation of the second messenger cyclic dimeric guanosine monophosphate (c-di-GMP) levels by the PAS-containing c-di-GMP phosphodiesterase, BCAL1069 (CdpA), regulates the swimming motility of B...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29538493/burkholderia-cepacia-cystic-fibrosis-and-outcomes-following-lung-transplantation-experiences-from-a-single-center-in-brazil
#12
Danila de Souza Carraro, Rafael Medeiros Carraro, Silvia Vidal Campos, Leandro Ryuchi Iuamoto, Karina Andrighetti de Oliveira Braga, Lea Campos de Oliveira, Ester Cerdeira Sabino, Flavia Rossi, Paulo Manuel Pêgo-Fernandes
OBJECTIVES: To evaluate the impact of Burkholderia cepacia complex colonization in cystic fibrosis patients undergoing lung transplantation. METHODS: We prospectively analyzed clinical data and respiratory tract samples (sputum and bronchoalveolar lavage) collected from suppurative lung disease patients between January 2008 and November 2013. We also subtyped different Burkholderia cepacia complex genotypes via DNA sequencing using primers against the recA gene in samples collected between January 2012 and November 2013...
March 12, 2018: Clinics
https://www.readbyqxmd.com/read/29528522/survival-after-lung-transplantation-of-cystic-fibrosis-patients-infected-with-burkholderia-dolosa-genomovar-vi
#13
Ruobing Wang, Sebastian K Welsh, Marie Budev, Hilary Goldberg, Peadar G Noone, David Zaas, Debra Boyer
Cystic fibrosis (CF) with severe lung disease is a well-recognized indication for lung transplantation. Colonization with various organisms in CF patients may impact post-transplant morbidity and mortality. Burkholderia cepacia complex (BCC) is made up of distinct genomovars with significant morbidity and mortality associated with B. cenocepacia (genomovar III) following lung transplant. The outcomes of patients infected with genomovar B. dolosa (genomovar VI) have yet to be described in the literature. We performed a retrospective chart review of all cystic fibrosis patients colonized with B...
March 12, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29513134/belfast-agar-a-simple-laboratory-medium-to-separate-pseudomonas-aeruginosa-from-pan-resistant-burkholderia-cenocepacia-isolated-from-the-sputum-of-patients-with-cystic-fibrosis-cf
#14
S Caskey, J E Moore, J McCaughan, J C Rendall
No abstract text is available yet for this article.
April 2018: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/29504898/on-burkholderiales-order-microorganisms-and-cystic-fibrosis-in-russia
#15
Olga L Voronina, Marina S Kunda, Natalia N Ryzhova, Ekaterina I Aksenova, Natalia E Sharapova, Andrey N Semenov, Elena L Amelina, Alexandr G Chuchalin, Alexandr L Gintsburg
BACKGROUND: Microbes infecting cystic fibrosis patients' respiratory tract are important in determining patients' functional status. Representatives of Burkholderiales order are the most dangerous. The goal of our investigation was to reveal the diversity of Burkholderiales, define of their proportion in the microbiome of various parts of respiratory tract and determine the pathogenicity of the main representatives. RESULTS: In more than 500 cystic fibrosis patients, representing all Federal Regions of Russia, 34...
February 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29498745/molecular-typing-of-burkholderia-cepacia-complex-isolated-from-patients-attending-an-italian-cystic-fibrosis-centre
#16
Antonio Teri, Samantha Sottotetti, Arianna Biffi, Daniela Girelli, Monica D'Accico, Milena Arghittu, Carla Colombo, Fabiola Corti, Giovanna Pizzamiglio, Lisa Cariani
Bacteria from the Burkholderia cepacia complex (Bcc) are capable of causing severe infections in patients with cystic fibrosis (CF). Bcc infection is often extremely difficult to treat due to its intrinsic resistance to multiple antibiotics. In addition, it seems to speed up the decline of lung function and is considered a contraindication for lung transplantation in CF. This study investigates the species of the Bcc strains recovered from chronically infected CF subjects by means of: isolation, identification methods and complete recA nucleotide sequences of 151 samples...
March 2, 2018: New Microbiologica
https://www.readbyqxmd.com/read/29363827/a-novel-two-component-system-modulates-quorum-sensing-and-pathogenicity-in-burkholderia-cenocepacia
#17
Chaoyu Cui, Chunxi Yang, Shihao Song, Shuna Fu, Xiuyun Sun, Liang Yang, Fei He, Lian-Hui Zhang, Yongliang Zhang, Yinyue Deng
Quorum sensing (QS) is widely utilized by bacterial pathogens to regulate biological functions and pathogenicity. Recent evidence has shown that QS is subject to regulatory cascades, especially two-component systems that often respond to environmental stimulation. At least two different types of QS systems regulate pathogenesis in Burkholderia cenocepacia. However, it remains unclear how this bacterial pathogen controls these QS systems. Here, we demonstrate a novel two-component system RqpSR (Regulating Quorum sensing and Pathogenicity), which plays an important role in modulating QS and pathogenesis in B...
April 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29360487/development-of-an-sce-i-mutagenesis-system-for-burkholderia-cepacia-complex-strains
#18
Ashraf Abdu, Gerardo Juarez-Lara, Jonathan J Dennis
The Burkholderia cepacia complex (Bcc) consists of at least 20 phenotypically similar but genotypically distinct Gram-negative bacteria that are ubiquitous in nature, are capable of promoting plant growth and biodegradation of pollutants, but that also are highly antibiotic resistant and produce damaging effects towards plants, fungi, and humans. To study these genetically recalcitrant bacteria in detail, molecular tools are required that work efficiently with the many strains and species of the Bcc. One mutagenesis strategy that has been used effectively to analyze the genes of Burkholderia cenocepacia is based upon the activity of the Sce-I restriction enzyme...
March 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29359187/the-small-rna-ncs35-regulates-growth-in-burkholderia-cenocepacia-j2315
#19
Sanne Kiekens, Andrea Sass, Filip Van Nieuwerburgh, Dieter Deforce, Tom Coenye
Burkholderia cenocepacia J2315 is a member of the B. cepacia complex. It has a large genome with three replicons and one plasmid; 7,261 genes code for annotated proteins, while 113 code for functional RNAs. Small regulatory RNAs of B. cenocepacia have not yet been functionally characterized. We investigated a small regulatory RNA, designated ncS35, that was discovered by differential RNA sequencing. Its expression under various conditions was quantified, and a deletion mutant, ΔncS35, was constructed. Compared to planktonic growth in a rich medium, the expression of ncS35 was elevated when B...
January 2018: MSphere
https://www.readbyqxmd.com/read/29322563/microfluidics-based-lc-ms-mrm-approach-for-the-relative-quantification-of-burkholderia-cenocepacia-secreted-virulence-factors
#20
Sofie Depluverez, Simon Daled, Stijn De Waele, Sören Planckaert, Jolien Schoovaerts, Dieter Deforce, Bart Devreese
Burkholderia cenocepacia is an opportunistic pathogen that is commonly isolated from patients with cystic fibrosis (CF). Several virulence factors have been identified, including extracellular enzymes that are secreted by type II and type VI secretion systems. The activity of these secretion systems is modulated by quorum sensing. Apart from the classical acylhomoserine lactone quorum sensing, B. cenocepacia also uses the diffusible signal factor system (DSF) i.e. 2-undecenoic acid derivatives that are recognized by specific receptors resulting in changes in biofilm formation, motility and virulence...
January 11, 2018: Rapid Communications in Mass Spectrometry: RCM
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