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radiation knowledge based planning

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https://www.readbyqxmd.com/read/29764450/evaluation-of-target-dose-inhomogeneity-in-breast-cancer-treatment-due-to-tissue-elemental-differences
#1
A Fogliata, F De Rose, A Stravato, G Reggiori, S Tomatis, M Scorsetti, L Cozzi
BACKGROUND: Monte Carlo simulations were run to estimate the dose variations generated by thedifference arising from the chemical composition of the tissues. METHODS: CT datasets of five breast cancer patients were selected. Mammary gland was delineated as clinical target volume CTV, as well as CTV_lob and CTV_fat, being the lobular and fat fractions of the entire mammary gland. Patients were planned for volumetric modulated arc therapy technique, optimized in the Varian Eclipse treatment planning system...
May 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29745754/modelling-the-influence-of-treatment-time-on-radiosurgery-single-treatment-biological-effectiveness-to-produce-protective-dose-modification-factors
#2
Bleddyn Jones, John W Hopewell
OBJECTIVE: To provide simpler models for adjusting total dose to compensate for significant variations in CNS radio-surgical treatment times, which vary and will influence treatment bio-effectiveness. At present, no allowance is made for time variations. A framework of simpler equations would allow radio-surgical outcomes to be analysed with respect to treatment time, and a system for dose adjustments between radio-isotope and linac-based techniques with different treatment durations...
May 10, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29735195/robust-proton-treatment-planning-physical-and-biological-optimization
#3
REVIEW
Jan Unkelbach, Harald Paganetti
Accurate prediction of tumor control and toxicities in radiation therapy faces many uncertainties. Besides interpatient variability in the response to radiation, there are also dosimetric uncertainties, that is, differences between the dose displayed in a treatment planning system and the dose actually delivered to the patient. These uncertainties originate from several sources including imperfect knowledge of the patient geometry, approximation in the physics of radiation interaction with tissues, and uncertainties in the biological effectiveness of radiation...
April 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29714086/a-dosimetric-evaluation-on-applying-rtog-based-and-ct-mri-based-delineation-methods-to-brachial-plexus-in-radiotherapy-of-nasopharyngeal-carcinoma-treated-with-helical-tomotherapy
#4
Chi-Him Li, Vincent Wc Wu, George Chiu
OBJECTIVE: In radiotherapy of nasopharyngeal carcinoma (NPC) patients, the brachial plexus (BP) situating at both sides of the neck are often irradiated to high dose. This study was to evaluate different BP delineation methods and analyse the dosimetric consequences when applying BP dose constraints in radiotherapy planning of NPC. METHODS: 15 NPC cases treated radically with helical tomotherapy were recruited. Apart from the original treatment plan (Plan A), two new plans (Plan B & C) with additional BP dose constraints were computed using the same planning computed tomography (CT) images, structures and planning parameters...
May 1, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29679492/knowledge-based-automated-planning-for-oropharyngeal-cancer
#5
Aaron Babier, Justin J Boutilier, Andrea L McNiven, Timothy C Y Chan
PURPOSE: To automatically generate radiation therapy plans for oropharynx patients by com-bining knowledge-based planning (KBP) predictions with an inverse optimization (IO) pipeline. METHODS: We developed two KBP approaches, the bagging query (BQ) method and the generalized principal component analysis-based (gPCA) method, to predict achievable dose volume histograms (DVHs). These approaches generalize existing methods by predicting physically feasible organ-at-risk (OAR) and target DVHs in sites with multiple targets...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29669165/the-state-of-survivorship-care-in-radiation-oncology-results-from-a-nationally-distributed-survey
#6
Melissa A Frick, Seth A Rosenthal, Neha Vapiwala, Brian T Monzon, Abigail T Berman
BACKGROUND: Survivorship care has become an increasingly critical component of oncologic care as well as a quality practice and reimbursement metric. To the authors' knowledge, the current climate of survivorship medicine in radiation oncology has not been investigated fully. METHODS: An institutional review board-approved, Internet-based survey examining practices and preparedness in survivorship care was distributed to radiation oncology practices participating in the American College of Radiology Radiation Oncology Practice Accreditation program between November 2016 and January 2017...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29657683/radiation-protection-knowledge-attitude-and-practice-kap-in-interventional-radiology
#7
Fatemeh Shabani, Hadi Hasanzadeh, Alireza Emadi, Majid Mirmohammadkhani, Ahmad Bitarafan-Rajabi, Ali Abedelahi, Mitra Bokharaeian, Hamed Masoumi, Danial Seifi, Tahereh Khani, Mohamad Sanchooli, Shima Moshfegh, Abbas Ziari
Objectives: Due to increasing cardiac disease and its mortality rate, the frequency of cardiac imaging has grown and, as a result, interventional cardiologists potentially receive high radiation doses in cardiac examinations. This study aimed to assess the knowledge, attitude, and practice (KAP) level of radiation protection (RP) among interventional radiology staff in Iranian health care centers across the country. Methods: We used a validated questionnaire survey consisting of 30 multiple-choice questions to perform a cross-sectional study...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29619963/national-cancer-institute-workshop-on-proton-therapy-for-children-considerations-regarding-brainstem-injury
#8
REVIEW
Daphne Haas-Kogan, Daniel Indelicato, Harald Paganetti, Natia Esiashvili, Anita Mahajan, Torunn Yock, Stella Flampouri, Shannon MacDonald, Maryam Fouladi, Kry Stephen, John Kalapurakal, Stephanie Terezakis, Hanne Kooy, David Grosshans, Mike Makrigiorgos, Kavita Mishra, Tina Young Poussaint, Kenneth Cohen, Thomas Fitzgerald, Vinai Gondi, Arthur Liu, Jeff Michalski, Dragan Mirkovic, Radhe Mohan, Stephanie Perkins, Kenneth Wong, Bhadrasain Vikram, Jeff Buchsbaum, Larry Kun
PURPOSE: Proton therapy can allow for superior avoidance of normal tissues. A widespread consensus has been reached that proton therapy should be used for patients with curable pediatric brain tumor to avoid critical central nervous system structures. Brainstem necrosis is a potentially devastating, but rare, complication of radiation. Recent reports of brainstem necrosis after proton therapy have raised concerns over the potential biological differences among radiation modalities. We have summarized findings from the National Cancer Institute Workshop on Proton Therapy for Children convened in May 2016 to examine brainstem injury...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29616187/an-ensemble-approach-to-knowledge-based-intensity-modulated-radiation-therapy-planning
#9
Jiahan Zhang, Q Jackie Wu, Tianyi Xie, Yang Sheng, Fang-Fang Yin, Yaorong Ge
Knowledge-based planning (KBP) utilizes experienced planners' knowledge embedded in prior plans to estimate optimal achievable dose volume histogram (DVH) of new cases. In the regression-based KBP framework, previously planned patients' anatomical features and DVHs are extracted, and prior knowledge is summarized as the regression coefficients that transform features to organ-at-risk DVH predictions. In our study, we find that in different settings, different regression methods work better. To improve the robustness of KBP models, we propose an ensemble method that combines the strengths of various linear regression models, including stepwise, lasso, elastic net, and ridge regression...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29573921/the-impact-of-daily-bladder-filling-on-small-bowel-dose-for-intensity-modulated-radiation-therapy-for-cervical-cancer
#10
Victor E Chen, Erin F Gillespie, Ryan P Manger, Lauren A Skerritt, Josephine H Tran, James A Proudfoot, Michael V Sherer, John P Einck, Loren K Mell, Kevin L Moore, Catheryn M Yashar
Research demonstrates that instructing patients to have a full bladder for pelvic radiotherapy results in highly variable bladder volumes at daily treatment. We aimed to determine bladder volume variation in patients with intact cervical cancer treated with intensity-modulated radiotherapy (IMRT) on an empty bladder and estimate the difference in radiation dose to the small bowel compared to treating on a full bladder. We identified 29 patients treated with IMRT from 2010 to 2013 who underwent 2 planning computed tomography (CT) scans, 1 with a full bladder followed by 1 with an empty bladder...
March 21, 2018: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/29558940/evaluation-of-multiple-institutions-models-for-knowledge-based-planning-of-volumetric-modulated-arc-therapy-vmat-for-prostate-cancer
#11
Yoshihiro Ueda, Jun-Ichi Fukunaga, Tatsuya Kamima, Yumiko Adachi, Kiyoshi Nakamatsu, Hajime Monzen
BACKGROUND: The aim of this study was to evaluate the performance of a commercial knowledge-based planning system, in volumetric modulated arc therapy for prostate cancer at multiple radiation therapy departments. METHODS: In each institute, > 20 cases were assessed. For the knowledge-based planning, the estimated dose (ED) based on geometric and dosimetric information of plans was generated in the model. Lower and upper limits of estimated dose were saved as dose volume histograms for each organ at risk...
March 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29536200/patient-education-using-virtual-reality-increases-knowledge-and-positive-experience-for-breast-cancer-patients-undergoing-radiation-therapy
#12
Yobelli A Jimenez, Steven Cumming, Wei Wang, Kirsty Stuart, David I Thwaites, Sarah J Lewis
PURPOSE: Improved access to technology in the radiation therapy (RT) workforce education has resulted in opportunities for innovative patient education methods. This study investigated the impact of a newly developed education tool using the Virtual Environment for Radiotherapy Training (VERT) system on patients' RT knowledge and anxiety. METHOD: Breast cancer patients were recruited into a control group (CG) (n = 18) who underwent the standard pre-RT education package at a targeted cancer therapy centre, followed by a VERT group (VG) (n = 19)...
March 13, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29485048/improving-quality-and-consistency-in-nrg-oncology-radiation-therapy-oncology-group-0631-for-spine-radiosurgery-via-knowledge-based-planning
#13
Kelly C Younge, Robin B Marsh, Dawn Owen, Huaizhi Geng, Ying Xiao, Daniel E Spratt, Joseph Foy, Krithika Suresh, Q Jackie Wu, Fang-Fang Yin, Samuel Ryu, Martha M Matuszak
PURPOSE: To use knowledge-based planning (KBP) as a method of producing high-quality, consistent, protocol-compliant treatment plans in a complex setting of spine stereotactic body radiation therapy on NRG Oncology Radiation Therapy Oncology Group (RTOG) 0631. METHODS AND MATERIALS: An internally developed KBP model was applied to an external validation cohort of 22 anonymized cases submitted under NRG Oncology RTOG 0631. The original and KBP plans were compared via their protocol compliance, target conformity and gradient index, dose to critical structures, and dose to surrounding normal tissues...
March 15, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29457287/zero-te-based-pseudo-ct-image-conversion-in-the-head-and-its-application-in-pet-mr-attenuation-correction-and-mr-guided-radiation-therapy-planning
#14
Florian Wiesinger, Mikael Bylund, Jaewon Yang, Sandeep Kaushik, Dattesh Shanbhag, Sangtae Ahn, Joakim H Jonsson, Josef A Lundman, Thomas Hope, Tufve Nyholm, Peder Larson, Cristina Cozzini
PURPOSE: To describe a method for converting Zero TE (ZTE) MR images into X-ray attenuation information in the form of pseudo-CT images and demonstrate its performance for (1) attenuation correction (AC) in PET/MR and (2) dose planning in MR-guided radiation therapy planning (RTP). METHODS: Proton density-weighted ZTE images were acquired as input for MR-based pseudo-CT conversion, providing (1) efficient capture of short-lived bone signals, (2) flat soft-tissue contrast, and (3) fast and robust 3D MR imaging...
February 18, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29447260/optimal-dose-reduction-algorithm-using-an-attenuation-based-tube-current-modulation-method-for-cone-beam-ct-imaging
#15
Kihong Son, Jieun Chang, Hoyeon Lee, Changhwan Kim, Taewon Lee, Seungryong Cho, Sohyun Park, Jin Sung Kim
To reduce the radiation dose given to patients, a tube current modulation (TCM) method has been widely used in diagnostic CT systems. However, the TCM method has not yet been applied to a kV-CBCT system on a LINAC machine. The purpose of this study is to investigate if a TCM method would be desirable in a kV-CBCT system for image-guided radiation therapy (IGRT) or not. We have developed an attenuation-based TCM method using prior knowledge from planning CT images of patients. The TCM method can provide optimized dose reductions without degrading image quality for kV-CBCT imaging...
2018: PloS One
https://www.readbyqxmd.com/read/29235457/serum-metabolic-profile-alteration-reveals-response-to-platinum-based-combination-chemotherapy-for-lung-cancer-sensitive-patients-distinguished-from-insensitive-ones
#16
Shan Xu, Yanping Zhou, Hui Geng, Dandan Song, Jing Tang, Xianmin Zhu, Di Yu, Sheng Hu, Yanfang Cui
Most lung cancers are diagnosed at fairly advanced stages due to limited clinical symptoms. Platinum-based chemotherapy, either as single regimen or in combination with radiation, is one of the major recommendations for the patients. Earlier evaluation of the effectiveness of the chemotherapies is critical for developing better treatment plan given the toxicity of the chemotherapeutic reagents. Drug efficacy could be reflected in the systemic metabolism characteristics though knowledge about which remains scarce...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29225692/recent-advances-in-radiation-oncology
#17
REVIEW
Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi, Rosalinda Ricotti
Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29206597/quantitative-proteomic-analysis-of-the-hippocampus-of-rats-with-gcr-induced-spatial-memory-impairment
#18
Sucharita M Dutta, Melissa M Hadley, Scott Peterman, Jessica S Jewell, Vania D Duncan, Richard A Britten
NASA is planning future missions to Mars, which will result in astronauts being exposed to ∼13 cGy/year of galactic cosmic radiation (GCR). Previous ground-based experiments have demonstrated that low (15 cGy) doses of 1 GeV/n56 Fe ions impair hippocampus-dependent spatial memory in rats. However, some irradiated rats maintain a spatial memory performance comparable to that seen in the sham-irradiated rats, suggesting that some of these animals are able to ameliorate the deleterious effects of the GCR, while others are not...
February 2018: Radiation Research
https://www.readbyqxmd.com/read/29195563/awareness-of-medical-radiation-exposure-among-patients-a-patient-survey-as-a-first-step-for-effective-communication-of-ionizing-radiation-risks
#19
F Ria, A Bergantin, A Vai, P Bonfanti, A S Martinotti, I Redaelli, M Invernizzi, G Pedrinelli, G Bernini, S Papa, E Samei
INTRODUCTION: The European Directive 2013/59/EURATOM requires patient radiation dose information to be included in the medical report of radiological procedures. To provide effective communication to the patient, it is necessary to first assess the patient's level of knowledge regarding medical exposure. The goal of this work is to survey patients' current knowledge level of both medical exposure to ionizing radiation and professional disciplines and communication means used by patients to garner information...
November 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/29174796/knowledge-based-treatment-planning-and-its-potential-role-in-the-transition-between-treatment-planning-systems
#20
Kathryn Masi, Paul Archer, William Jackson, Yilun Sun, Matthew Schipper, Daniel Hamstra, Martha Matuszak
Commissioning a new treatment planning system (TPS) involves many time-consuming tasks. We investigated the role that knowledge-based planning (KBP) can play in aiding a clinic's transition to a new TPS. Sixty clinically treated prostate/prostate bed intensity-modulated radiation therapy (IMRT) plans were exported from an in-house TPS and were used to create a KBP model in a newly implemented commercial application. To determine the benefit that KBP may have in a TPS transition, the model was tested on 2 groups of patients...
November 22, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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